MISSION WEST PROPERTIES, INC.
                    10050 Bandley Drive, Cupertino, CA 95014
                        Ph. 408-725-0700 Fax 408-725-1626


November 30, 2006

Ms. Linda van Doorn
Senior Assistant Chief Accountant
United States Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549

        Re: Mission West Properties, Inc.
        Response to Comments from the SEC on Form 10-K for Fiscal Year Ended
        December 31, 2005, filed March 16, 2006
        Forms 10-Q for the Fiscal Quarters Ended March 31, June 30 and September
        30, 2006, filed May 10, August 8 and November 8, 2006
        File No. 0-25235

Dear Ms. van Doorn:

This  letter  sets  forth  responses  of  Mission  West  Properties,  Inc.  (the
"Company") to your comments relating to the Company's Annual Report on Form 10-K
and Quarterly  Reports on Form 10-Q  contained in your letter dated November 20,
2006.  The Staff  comment is  repeated  in bold type  below,  and the  Company's
response appears immediately beneath each comment.

FORM 10-Q FOR THE QUARTER ENDED MARCH 31, 2006

FINANCIAL STATEMENTS

NOTE 5. VARIABLE INTEREST ENTITY, PAGE 7

1.   PLEASE PROVIDE US WITH ADDITIONAL  INFORMATION AS TO HOW YOU DETERMINED M&M
     REAL  ESTATE  CONTROL  &  RESTRUCTURING,  LLC IS A VIE AND THAT YOU ARE THE
     PRIMARY BENEFICIARY IN ACCORDANCE WITH FIN 46(R).

     Following  the dramatic loss of jobs in the Silicon  Valley  created by the
     dot.com  bust there has been very  modest job  creation  as a result of the
     impact of outsourcing and off-shoring of jobs and increasing  productivity.
     This has  resulted in a very  gradual  recovery in the Silicon  Valley real
     estate  market.  As a result of these  market  conditions,  M&M Real Estate
     Control  &  Restructuring,  LLC  ("M&M")  was  formed  by two  individuals,
     unrelated  to Mission West  Properties,  L.P.  ("MSW"),  for the purpose of
     completing  transactions  similar to the one described  below for landlords
     that want to have the ability to lease buildings on a



     long-term  basis and would be prevented from doing so since those buildings
     are leased by tenants  who have  vacated  the  buildings,  have no plans to
     re-occupy the buildings,  and have been unable to sublease all or a portion
     of these  buildings.  One of the M&M  principals  is a licensed real estate
     agent.

     In late 2005, M&M held discussions with MSW regarding a potential  business
     opportunity whereby in the case of a MSW tenant that is not occupying space
     that it leases from MSW, the tenant may be  interested,  subject to certain
     conditions  and  incentives,  in  assigning  their lease to M&M in order to
     remove the lease from their financial  reporting and day to day management.
     M&M  proposed:  (i) MSW  consent  to the  assignment  of lease from the MSW
     tenant  to M&M for the  leased  premises;  (ii) MSW would  release  the MSW
     tenant from any liability,  except for third party claims and any hazardous
     materials during the lease term prior to the assignment,  if the MSW tenant
     paid  M&M the  balance  of its  future  lease  obligation  net of a  modest
     discount  (approximately  3% to 4%); (iii)  following the assignment of the
     MSW tenant's lease to M&M, M&M would immediately commence marketing efforts
     to  sub-lease  the space;  and (iv) in the event M&M found  another  tenant
     acceptable to MSW, M&M would receive a leasing commission.

     Under  FIN 46 (R)  for an  entity  to  qualify  as a VIE one or more of the
     following three characteristics must exist:

     1.   The equity  investment at risk is not  sufficient to permit the entity
          to finance its activities  without additional  subordinated  financial
          support by any parties, including the equity holders.
     2.   The  equity  investors  lack  one or more of the  following  essential
          characteristics of a controlling financial interest:
          a.   The  direct  or  indirect  ability  to make  decisions  about the
               entity's activities through voting or similar rights
          b.   The obligation to absorb the expected loss of the entity
          c.   The right to receive the expected residual returns of the entity.
     3.   The equity investors have voting rights that are not  proportionate to
          their economic interests,  and the activities of the entity involve or
          are conducted on behalf of an investor with a disproportionately small
          voting interest.

     Factors  considered  by  management  in  determining  whether M&M should be
     considered a VIE for financial reporting purposes included the following:
     -    No equity was contributed by the partners in the formation of M&M.
     -    At present,  the MSW  assignment of a lease is the only property under
          management by M&M.
     -    Because  M&M is a newly  formed  entity it does not have an  operating
          history  that  demonstrates  its  ability  to finance  its  activities
          without additional subordinated financial support.
     -    All revenues,  other than interest  income,  are generated by M&M from
          MSW in the form of fees or commissions.



     -    MSW remains at risk,  because if M&M's  operating  expenses exceed its
          interest  income,  fees and  commissions  there would be  insufficient
          funds  to  meet  the  assigned  lease  obligation  without  additional
          financial support from equity holders or other parties. MSW, which had
          released the  original  tenant from its  obligations  under the lease,
          would have to absorb the  majority of any loss,  making it the primary
          beneficiary of M&M's activities.

     Based  on the  proposed  structure,  MSW  determined,  and our  independent
     accountants (BDO Seidman LLP and Burr, Pilger & Mayer LLP) concurred,  that
     the most appropriate  financial accounting for this transaction would be to
     account  for M&M as a VIE  since it met  characteristic  number 1  outlined
     above under FIN 46(R) resulting in recording the lease assignment to M&M as
     a lease  termination  and recording the funds  received by M&M from the MSW
     tenant as restricted  cash on MSW's balance sheet.  As each month's rent is
     paid by M&M under the assigned lease to MSW, the restricted cash balance is
     reduced.

ITEM 4. CONTROLS AND PROCEDURES, PAGE 24

2.   WE NOTE YOUR  STATEMENT  THAT "IN DESIGNING AND  EVALUATING  THE DISCLOSURE
     CONTROLS  AND  PROCEDURES,  MANAGEMENT  RECOGNIZES  THAT ANY  CONTROLS  AND
     PROCEDURES,  NO MATTER HOW WELL  DESIGNED  AND  OPERATED,  CAN PROVIDE ONLY
     REASONABLE  ASSURANCE  OF  ACHIEVING  THE DESIRED  CONTROL  OBJECTIVES  AND
     MANAGEMENT  NECESSARILY IS REQUIRED TO APPLY ITS JUDGMENT IN EVALUATING THE
     COST-BENEFIT  RELATIONSHIP  OF POSSIBLE  CONTROLS AND  PROCEDURES."  PLEASE
     CONFIRM TO US AND REVISE IN FUTURE FILINGS TO DISCLOSE,  IF TRUE, THAT YOUR
     DISCLOSURE  CONTROLS  AND  PROCEDURES  ARE  DESIGNED TO PROVIDE  REASONABLE
     ASSURANCE OF ACHIEVING  THEIR  OBJECTIVES AND THAT YOUR OFFICERS  CONCLUDED
     THAT  YOUR  DISCLOSURE  CONTROLS  AND  PROCEDURES  ARE  EFFECTIVE  AT  THAT
     REASONABLE  ASSURANCE  LEVEL.  IN  THE  ALTERNATIVE,  YOU  MAY  REMOVE  THE
     REFERENCE  TO THE  LEVEL  OF  ASSURANCE  OF YOUR  DISCLOSURE  CONTROLS  AND
     PROCEDURES  IN  FUTURE   FILINGS.   PLEASE  REFER  TO  SECTION   II.F.4  OF
     MANAGEMENT'S  REPORTS ON INTERNAL  CONTROL  OVER  FINANCIAL  REPORTING  AND
     CERTIFICATION OF DISCLOSURE IN EXCHANGE ACT PERIODIC  REPORTS,  SEC RELEASE
     NO.       33-8238,       AVAILABLE       ON      OUR       WEBSITE       AT
     http://www.sec.gov/rules/final/33-8238.htm. PLEASE PROVIDE US WITH THE SAME
     CONFIRMATION  AS IT RELATES TO YOUR OFFICERS'  CONCLUSIONS ON YOUR CONTROLS
     AND PROCEDURES AS OF JUNE 30, 2006 AND SEPTEMBER 30, 2006.

     We confirm to you our officers'  conclusions on our controls and procedures
     as of March 31, 2006, June 30, 2006 and September 30, 2006 were designed to
     provide  reasonable  assurance of achieving  their  objectives and that our
     officers  concluded  that  our  disclosure  controls  and  procedures  were
     effective at that reasonable assurance level.



     We will revise our  disclosure in future filings to remove the reference to
the level of assurance of our disclosure controls and procedures.

     In connection with the foregoing responses to your comments, the Registrant
acknowledges:

     -    The  Company is  responsible  for the  adequacy  and  accuracy  of the
          disclosure in the filing;
     -    SEC staff  comments or changes to  disclosure in response to SEC staff
          comments do not  foreclose the SEC from taking any action with respect
          to the filing; and
     -    The  Company  may not  assert SEC staff  comments  as a defense in any
          proceeding  initiated  by the  SEC or any  person  under  the  federal
          securities laws of the United States.

Sincerely,
Mission West Properties, Inc.
/s/ Carl E. Berg
Carl E. Berg
Chairman and CEO