UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                Current Report Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

        Date of report (date of earliest event reported): April 16, 2008

                          MISSION WEST PROPERTIES, INC.
             (Exact name of registrant as specified in its charter)

             Maryland              Commission File Number:         95-2635431
             --------                     1-8383                   ----------
(State or other jurisdiction of                                 (I.R.S. Employer
         incorporation)                                          Identification)


                    10050 Bandley Drive, Cupertino, CA 95014
                    (Address of principal executive offices)

                                 (408) 725-0700
              (Registrant's telephone number, including area code)

      Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
           following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act
    (17 CFR 230.425)
[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act
    (17 CFR 240.14a-12)
[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
    Act (17 CFR 240.14d-2(b))
[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
    Act (17 CFR 240.13e-4(c))

- --------------------------------------------------------------------------------

                                     - 1 -



ITEM 2.02.    RESULTS OF OPERATIONS AND FINANCIAL CONDITION.

(a)  The following information is being furnished by the Company as required for
     Item  2.02(a)  of this  report  and shall not be deemed to be  "filed"  for
     purposes of Section 18 of the Securities Exchange Act of 1934:

On April 16, 2008,  the Company  issued a press release  announcing its earnings
results  for the first  quarter  ended  March 31,  2008.  The press  release  is
attached to this Current Report as Exhibit 99.1 and is incorporated by reference
in response to Item 2.02(a) of this report.




- --------------------------------------------------------------------------------

                                    SIGNATURE

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.




                                     MISSION WEST PROPERTIES, INC.

Date: April 17, 2008                 By: /s/ Wayne N. Pham
                                     ------------------------------------------
                                     Wayne N. Pham
                                     Vice President of Finance and Controller

                                     - 2 -



Exhibit 99.1

                                                                   PRESS RELEASE

For Immediate News Release
April 16, 2008


     MISSION WEST PROPERTIES ANNOUNCES FIRST QUARTER 2008 OPERATING RESULTS

  "We build the buildings for the high tech companies that build the internet"


Cupertino, CA - Mission West Properties,  Inc. (NASDAQ: MSW) reported today that
Funds  From  Operations  ("FFO")  for the  quarter  ended  March  31,  2008  was
approximately  $15,223,000  or $0.14 per diluted common share  (considering  the
potential  effect of all O.P. units being  exchanged for shares of the Company's
common  stock) as compared  to  approximately  $23,905,000  or $0.23 per diluted
common share for the same period in 2007. On a sequential quarter basis, FFO for
the quarter ended December 31, 2007 was  approximately  $0.13 per diluted common
share.  Termination  fees and security  deposit  forfeitures  income relating to
lease terminations accounted for approximately  $1,921,000, or $0.02 per diluted
common share and $10,109,000, or $0.10 per diluted common share for the quarters
ended March 31, 2008 and 2007, respectively.  Write-off of an above market lease
intangible asset against income relating to one lease termination  accounted for
approximately  $3,619,000,  or $0.03 per  diluted  common  share for the quarter
ended March 31, 2007.

Net income per diluted  share to common  stockholders  was $0.10 for the quarter
ended March 31, 2008  compared to $0.17 for the quarter  ended March 31, 2007, a
per share decrease of approximately 41.1%. Termination fees and security deposit
forfeitures  income relating to lease  terminations  accounted for approximately
$0.02 and $0.10 per diluted  common share for the quarters  ended March 31, 2008
and 2007,  respectively.  Write-off of in-place lease intangible  assets against
income relating to two lease terminations  accounted for approximately $0.04 per
diluted common share for the quarter ended March 31, 2007.

ACQUISITION ACTIVITY

In January  2008,  the  Company  acquired a vacant R&D  property  consisting  of
approximately  110,500 rentable square feet located at 5981 Optical Court in San
Jose,  California  from the Berg  Group  under  the Berg  Land  Holdings  Option
Agreement for an acquisition cost of approximately $19,068,000. The building was
leased  within  several  days of the  acquisition.  The first  year  anticipated
un-leveraged cash return for this property is approximately 11.5%.

In February 2008, the Company acquired a fully leased  office/R&D  property with
approximately 75,300 rentable square feet located at 2904 Orchard Parkway in San
Jose,  California from an unrelated third party. The total acquisition price for
this property was  approximately  $16,696,000 and was partially  funded from the
proceeds  received from the 1170 Morse Avenue  property sale in September  2007,
which was classified as restricted  cash as of December 31, 2007. The first year
anticipated un-leveraged cash return for this property is approximately 7.3%.

                                     - 3 -





COMPANY PROFILE

Mission West Properties, Inc. operates as a self-managed,  self-administered and
fully integrated REIT engaged in the management, leasing, marketing, development
and acquisition of commercial R&D properties,  primarily  located in the Silicon
Valley portion of the San Francisco Bay Area. Currently, the Company manages 111
properties  totaling  approximately  8.0 million  rentable  square  feet,  which
includes  approximately  854,000 rentable square feet (or 16 buildings) that are
in the process of being  rezoned for  residential  development.  For  additional
information, please contact Investor Relations at 408-725-0700.

The matters described herein contain forward-looking statements. Such statements
can be  identified  by the use of  forward-looking  terminology  such as "will,"
"anticipate," "estimate," "expect," "intends," or similar words. Forward-looking
statements involve a number of risks,  uncertainties or other factors beyond the
Company's  control,  which may cause  material  differences  in actual  results,
performance or other  expectations.  These factors include,  but are not limited
to, the ability to complete  acquisitions  under the Berg Land  Holdings  Option
Agreement  with the Berg  Group  and other  factors  detailed  in the  Company's
registration  statements,  and periodic  filings with the  Securities & Exchange
Commission.

                                     - 4 -



                          MISSION WEST PROPERTIES, INC.
                             SELECTED FINANCIAL DATA
        (In thousands, except share, per share and property data amounts)




                                                    Three Months        Three Months
                                                       Ended               Ended
                                                    Mar 31, 2008        Mar 31, 2007
                                                  ----------------    ----------------
REVENUES:
                                                                
Rental revenue from real estate                       $18,996             $21,202
Above market lease intangible asset amortization            -              (4,091) (1)
Tenant reimbursements                                   3,583               3,214
Lease termination income                                1,921              10,109
Other income, including interest                          786               3,056
                                                  ----------------    ----------------
  Total revenues                                       25,286              33,490
                                                  ----------------    ----------------
EXPENSES:
Operating expenses                                      2,477               1,959
Real estate taxes                                       2,411               2,562
Interest                                                4,927               5,069
Interest (related parties)                                436                 184
General and administrative                                673                 713
Depreciation and amortization of real estate            5,623 (2)           6,154 (2)
                                                  ----------------    ----------------
  Total expenses                                       16,547              16,641
                                                  ----------------    ----------------
Income before equity in earnings of unconsolidated
   joint venture and minority interests                 8,739              16,849
Equity in earnings of unconsolidated joint venture        382                 337
Minority interests                                     (7,239)            (13,820)
                                                  ----------------    ----------------
  Income from continuing operations                     1,882               3,366
                                                  ----------------    ----------------
Discontinued operations, net of minority interests:
Income attributable to discontinued operations              -                   9
                                                  ----------------    ----------------
   Income from discontinued operations                      -                   9
                                                  ----------------    ----------------

Net income to common stockholders                      $1,882             $ 3,375
                                                  ================    ================
Net income to minority interests                       $7,239             $13,879
                                                  ================    ================
Income per share from continuing operations:
   Basic                                                $0.10               $0.17
                                                  ================    ================
   Diluted                                              $0.10               $0.17
                                                  ================    ================
Income per share from discontinued operations:
   Basic                                                    -                   -
                                                  ================    ================
   Diluted                                                  -                   -
                                                  ================    ================
Net income per share to common stockholders:
   Basic                                                $0.10               $0.17
                                                  ================    ================
   Diluted                                              $0.10               $0.17
                                                  ================    ================
Weighted average shares of common stock (basic)    19,667,605          19,582,787
                                                  ================    ================
Weighted average shares of common stock (diluted)  19,667,605          19,889,453
                                                  ================    ================
Weighted average O.P. units outstanding            85,530,417          85,066,999
                                                  ================    ================

FUNDS FROM OPERATIONS
Funds from operations                                 $15,223             $23,905
                                                  ================    ================
Funds from operations per share (3)                     $0.14               $0.23
                                                  ================    ================
Outstanding common stock                           19,669,807          19,625,587
                                                  ================    ================
Outstanding O.P. units                             85,528,215          85,024,199
                                                  ================    ================
Weighted average O.P. units and common stock
   outstanding (diluted)                          105,198,022        104,956,452
                                                  ================    ================


                                     - 5 -




                                                   Three Months        Three Months
                                                      Ended               Ended
FUNDS FROM OPERATIONS CALCULATION                  Mar 31, 2008        Mar 31, 2007
                                                  ----------------    ----------------
                                                                  
Net income                                           $  1,882            $  3,375
Add:
   Minority interests (4)                               7,128              13,755
   Depreciation and amortization of real estate from
      continuing operations                             6,024               6,530
   Depreciation and amortization of real estate from
      discontinued operations                               -                  56
   Depreciation & amortization of real estate held in
     unconsolidated joint venture                         189                 189
                                                  ----------------    ----------------
Funds from operations                                 $15,223             $23,905
                                                  ================    ================


Funds From Operations ("FFO") is a non-GAAP  financial  measurement used by real
estate investment trusts ("REITs") to measure and compare operating performance.
As defined by NAREIT,  FFO represents net income (loss) before minority interest
of unit  holders  (computed  in  accordance  with  GAAP,  accounting  principles
generally accepted in the United States of America), excluding gains (or losses)
from  debt  restructuring  and  sales of  property,  plus  real  estate  related
depreciation  and  amortization  (excluding  amortization of deferred  financing
costs and  depreciation  of non-real  estate assets) and after  adjustments  for
unconsolidated  partnerships and joint ventures.  Management considers FFO to be
an  appropriate  supplemental  measure of the Company's  operating and financial
performance  because  when  compared  year over year,  it reflects the impact to
operations  from trends in  occupancy  rates,  rental  rates,  operating  costs,
general and administrative  expenses and interest costs, providing a perspective
not immediately apparent from net income. In addition,  management believes that
FFO provides useful information about the Company's  financial  performance when
compared  to other  REITs  since FFO is  generally  recognized  as the  industry
standard for reporting the operations of REITs.  FFO should not be considered as
an alternative for net income as a measure of  profitability or is it comparable
to cash flows  provided by operating  activities  determined in accordance  with
GAAP. FFO is not comparable to similarly  entitled items reported by other REITs
that do not define them exactly as we define FFO.



                                                    Three Months       Three Months
                                                       Ended              Ended
PROPERTY AND OTHER DATA:                            Mar 31, 2008       Mar 31, 2007
                                                  ----------------    ----------------
                                                                 
Total properties, end of period                           111                 107
Total square feet, end of period                    8,047,569           7,701,359
Average monthly rental revenue per square foot (5)      $1.23               $1.50
Occupancy for leased properties                         64.4%                69.4%
Straight-line rent                                       $705             ($1,595)
Leasing commissions                                      $316              $  458
Capital expenditures                                     $221              $  863


                                     - 6 -











BALANCE SHEET                                   March 31, 2008       December 31, 2007
                                              --------------------  --------------------
Assets:
                                                                 
   Land                                          $   320,911           $   312,152
   Buildings and improvements                        790,770               764,665
   Real estate related intangible assets               3,240                 2,119
                                              --------------------  --------------------
      Total investments in properties              1,114,921             1,078,936
Less accumulated depreciation and amortization      (162,442)             (156,819)
                                              --------------------  --------------------
      Net investments in properties                  952,479               922,117
   Cash and cash equivalents                          21,611                23,691
   Restricted cash                                    48,640                65,509
   Deferred rent receivable                           15,539                14,833
   Investment in unconsolidated joint venture          2,667                 2,735
   Other assets, net                                  26,450                25,000
                                              --------------------  --------------------
      Total assets                               $ 1,067,386           $ 1,053,885
                                              ====================  ====================
Liabilities:
   Mortgage notes payable                        $   334,774           $   337,520
   Note payable - related parties                     19,316                     -
   Mortgage note payable - related parties             9,112                 9,224
   Interest payable                                    1,320                 1,331
   Security deposits                                   4,793                 4,754
   Deferred rental income                              4,775                 3,302
   Dividend/distribution payable                      21,040                16,832
   Accounts payable and accrued expenses              18,925                15,618
                                              --------------------  --------------------
      Total liabilities                              414,055               388,581
                                              --------------------  --------------------

Minority interests                                   516,504               526,626
                                              --------------------  --------------------

Stockholders' equity:
   Common stock, $.001 par value                          20                    20
   Additional paid-in capital                        153,224               153,024
   Distributions in excess of accumulated earnings   (16,417)              (14,366)
                                              --------------------  --------------------
      Total stockholders' equity                     136,827               138,678
                                              --------------------  --------------------
      Total liabilities and stockholders' equity $ 1,067,386           $ 1,053,885
                                              ====================  ====================


(1)  Amortization  of  an  above-market   lease  intangible  asset  pursuant  to
     Statement   of   Financial   Accounting   Standard   No.   141,   "Business
     Combinations."

(2)  Includes  approximately  $122 and $1,193 in  amortization  expense  for the
     three  months  ended  March  31,  2008  and  2007,  respectively,  for  the
     amortization of in-place lease value intangible asset pursuant to Statement
     of Financial Accounting Standard No. 141, "Business Combinations."

(3)  Calculated  on a fully diluted  basis.  Assumes  conversion  of O.P.  units
     outstanding into the Company's common stock.

(4)  The  minority  interest  for third  parties  has been  deducted  from total
     minority interest in calculating FFO.

(5)  Average  monthly  rental  revenue  per square foot has been  determined  by
     taking the cash base rent for the period divided by the number of months in
     the period,  and then  divided by the average  occupied  square feet in the
     period.