EXHIBIT 32.1
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             CERTIFICATION PURSUANT TO 18 U.S.C. SS.1350, AS ADOPTED
              PURSUANT TO SS.906 OF THE SARBANES-OXLEY ACT OF 2002


     In connection with the quarterly report of Spire Corporation (the
"Company") on Form 10-QSB (the "Report") for the period ended September 30, 2005
as filed with the Securities and Exchange Commission on the date hereof, I,
Roger G. Little, Chairman of the Board, Chief Executive Officer and President of
the Company, certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to
ss.906 of the Sarbanes-Oxley Act of 2002, that:

     1.   The Report fully complies with the requirements of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

     2.   The information contained in the report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.



Dated:    November 14, 2005                 By:  /s/ Roger G. Little
                                                 -------------------------------
                                                 Roger G. Little
                                                 Chairman of the Board,
                                                 Chief Executive Officer
                                                 and President






     A signed original of this written statement required by Section 906, or
other document authenticating, acknowledging, or otherwise adopting the
signatures that appear in typed form within the electronic version of this
written statement required by Section 906, has been provided to the Company and
will be retained by the Company and furnished to the Securities and Exchange
Commission or its staff upon request.