EXHIBIT 32.1
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             CERTIFICATION PURSUANT TO 18 U.S.C. SS.1350, AS ADOPTED
              PURSUANT TO SS.906 OF THE SARBANES-OXLEY ACT OF 2002


     In  connection  with  the  quarterly  report  of  Spire   Corporation  (the
"Company") on Form 10-Q/A (the  "Report") for the period ended March 31, 2008 as
filed with the Securities and Exchange  Commission on the date hereof,  I, Roger
G. Little,  Chief  Executive  Officer and  President  of the  Company,  certify,
pursuant  to  18  U.S.C.   ss.1350,   as  adopted  pursuant  to  ss.906  of  the
Sarbanes-Oxley Act of 2002, that:

     1. The Report fully  complies  with the  requirements  of Section  13(a) or
15(d) of the Securities Exchange Act of 1934; and

     2. The information contained in the Report fairly presents, in all material
respects, the financial condition and results of operations of the Company.


Dated: November 24, 2008               By: /s/ Roger G. Little
                                           -------------------------------
                                           Roger G. Little
                                           Chief Executive Officer and President


     A signed  original of this  written  statement  required by Section 906, or
other  document  authenticating,   acknowledging,   or  otherwise  adopting  the
signatures  that  appear in typed  form  within the  electronic  version of this
written statement  required by Section 906, has been provided to the Company and
will be retained by the Company and  furnished  to the  Securities  and Exchange
Commission or its staff upon request.