EXHIBIT 32.1
                                                                    ------------

             CERTIFICATION PURSUANT TO 18 U.S.C. SS.1350, AS ADOPTED
              PURSUANT TO SS.906 OF THE SARBANES-OXLEY ACT OF 2002


        In  connection  with the  quarterly  report  of Spire  Corporation  (the
"Company")  on Form 10-Q/A (the  "Report") for the period ended June 30, 2008 as
filed with the Securities and Exchange  Commission on the date hereof,  I, Roger
G. Little,  Chief  Executive  Officer and  President  of the  Company,  certify,
pursuant  to  18  U.S.C.   ss.1350,   as  adopted  pursuant  to  ss.906  of  the
Sarbanes-Oxley Act of 2002, that:

        1. The Report fully complies with the  requirements  of Section 13(a) or
15(d) of the Securities Exchange Act of 1934; and

        2. The  information  contained  in the Report  fairly  presents,  in all
material  respects,  the  financial  condition  and results of operations of the
Company.

Dated:  November 24, 2008              By:  /s/ Roger G. Little
                                           -------------------------------------
                                           Roger G. Little
                                           Chief Executive Officer and President


            A signed original of this written statement required by Section 906,
or other  document  authenticating,  acknowledging,  or  otherwise  adopting the
signatures  that  appear in typed  form  within the  electronic  version of this
written statement  required by Section 906, has been provided to the Company and
will be retained by the Company and  furnished  to the  Securities  and Exchange
Commission or its staff upon request.