EXHIBIT 32.1
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             CERTIFICATION PURSUANT TO 18 U.S.C. SS.1350, AS ADOPTED
              PURSUANT TO SS.906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the annual report of Spire Corporation (the "Company")
on Form 10-K (the "Report") for the year ended December 31, 2008 as filed with
the Securities and Exchange Commission on the date hereof, I, Roger G. Little,
Chairman of the Board, Chief Executive Officer and President of the Company,
certify, pursuant to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the
Sarbanes-Oxley Act of 2002, that:

     (1)  The Report fully complies with the requirements of Section 13(a) or
          15(d) of the Securities Exchange Act of 1934; and

     (2)  The information contained in the report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.


Dated: March 31, 2009                  By: /s/ Roger G. Little
                                           -------------------------------------
                                           Roger G. Little
                                           Chairman of the Board, Chief
                                           Executive Officer and President