Exhibit 2.1




                          AGREEMENT AND PLAN OF MERGER

                                  BY AND AMONG

                                 NEOSTEM, INC.,

                              CBH ACQUISITION LLC,

                     CHINA BIOPHARMACEUTICALS HOLDINGS, INC.

                                       AND

                         CHINA BIOPHARMACEUTICALS CORP.

                                November 2, 2008



                               TABLE OF CONTENTS



                                  EXHIBIT INDEX

Exhibit A - Class B Warrant
Exhibit B - Class C Warrant
Exhibit C - CBH Lock-Up and Voting Agreement
Exhibit D - Escrow Agreement
Exhibit E - Support Agreement
Exhibit F - Erye Letter of Intent to Enter into Amended and Restated Joint
            Venture Agreement
Exhibit G - CBH  Liability  Release
Exhibit H - Amended and Restated Erye Joint Venture Agreement
Exhibit I - NeoStem Lock-Up and Voting Agreement


                                       -i-



                                                               LS Draft 10/30/08

                          AGREEMENT AND PLAN OF MERGER

            This  Agreement  and Plan of Merger (this  "Agreement")  is made and
entered into as of the 2nd day of November,  2008, by and among NeoStem, Inc., a
Delaware  corporation  ("NeoStem"),  CBH  Acquisition  LLC, a  Delaware  limited
liability  company and a wholly owned  subsidiary  of NeoStem  ("Subco"),  China
Biopharmaceuticals  Holdings,  Inc.,  a Delaware  corporation  ("CBH") and China
Biopharmaceutical Corp., a British Virgin Islands corporation ("CBC").  NeoStem,
Subco and CBH are  sometimes  collectively  referred to as the  "Parties";  each
individually a "Party".

                             PRELIMINARY STATEMENTS

            A.  NeoStem  is  engaged  in a  platform  business  of  operating  a
commercial  autologous  adult  stem cell bank,  is  pioneering  the  pre-disease
collection, processing and long-term storage of stem cells from adult donors for
use for their own future  medical  treatment  and has entered into  research and
development  through  the  acquisition  of  a  worldwide  exclusive  license  of
technology to identify and isolate very small embryonic-like stem cells.

            B.  CBH  is  a   pharmaceutical   company   focused  on  developing,
manufacturing  and distributing  drugs in the PRC. CBH is a holding company with
two  subsidiaries,   Suzhou  Erye  Pharmaceuticals   Company  Ltd.  ("Erye"),  a
Sino-Foreign  joint venture with limited  liability  organized under the laws of
the  People's  Republic of China (the  "PRC"),  and CBC.  Erye is engaged in the
production and sale of injection drugs, capsule drugs, API and aluminum caps for
injection glass vials.

            C. NeoStem  desires to acquire CBH's 51% ownership  interest  ("Erye
Ownership")  in Erye plus net cash which shall not be less than  $550,000  after
payment of all  litigation  expenses and CBH Payable  Obligations  (the "Minimum
Cash").  Prior to the Merger (as  defined  below),  CBH will spin off all of its
shares of CBC  Common  Stock (as  defined  herein)  to CBH's  shareholders  in a
liquidating  distribution  (the  "Spin-Off") so that the only material assets of
CBH following the Spin-Off will be the Erye Ownership and cash.

            D. NeoStem desires to acquire the Erye Ownership  through the merger
of CBH (after the  Spin-off)  with and into Subco,  with Subco as the  surviving
entity (the  "Merger").  The Merger is intended  to be a tax-free  merger  under
Section  368(a)(1)(A)  of the Internal  Revenue Code (the  "Code").  Each of the
Parties has determined  that the Merger is consistent with and in furtherance of
its  respective  long-term  business  strategies  and  desires to combine  their
respective  businesses  and for the holders of shares of CBH Common Stock and/or
shares of CBH Preferred Stock (each, as defined herein) ("CBH  Stockholders") to
have a  continuing  equity  interest  in the  combined  NeoStem/Erye  businesses
through the ownership of NeoStem securities.



            E. Pursuant to the terms and subject to the  conditions set forth in
this Agreement as  consideration  in the Merger,  NeoStem shall issue to the CBH
Stockholders the following (collectively, the "Exchanged Securities"):

                  1.  7,500,000  shares of  NeoStem  Common  Stock  (as  defined
herein)  (the  "Exchanged  Common  Shares")  (of which  150,000  shares shall be
delivered  to the  Escrow  Agent to be held in  escrow  pursuant  to the  Escrow
Agreement  annexed as Exhibit D) to be issued to the holders of CBH Common Stock
(inclusive  of any CBH Common Stock issued upon exercise of any CBH Common Stock
Purchase Warrants prior to the Closing);

                  2. (a)  5,383,009  shares of NeoStem  Common  Stock  ("RimAsia
Exchanged Common Shares"),  (b) 6,977,512 shares of NeoStem Series C Convertible
Preferred  Stock (as defined  herein),  each with a  liquidation  preference  of
$1.125 and  convertible  to shares of  NeoStem  Common  Stock at $.90  ("RimAsia
Exchanged  Preferred  Shares") and (c) Class B warrants (the "Class B Warrants")
to purchase  2,400,000  shares of NeoStem  Common Stock at $0.80 per share under
the Class B Warrant  Agreement,  a copy of which is attached hereto as Exhibit A
(collectively,  the RimAsia  Exchanged  Common  Shares,  the  RimAsia  Exchanged
Preferred  Shares  and the Class B  Warrants  are  referred  to as the  "RimAsia
Exchanged  Securities"),   to  be  issued  to  RimAsia  Capital  Partners,  L.P.
("RimAsia"); and

                  3.  subject to  acceptance  by the holders of CBH Common Stock
Purchase  Warrants to purchase an  aggregate  of up to  7,831,684  shares of CBH
Common Stock (collectively,  the "CBH Common Stock Purchase Warrants"),  Class C
warrants (the "Class C Warrants") to purchase up to 2,012,097  shares of NeoStem
Common  Stock at an  exercise  price  equal to $2.50 per share under the Class C
Warrant  Agreement,  the form of which is  attached  here to as Exhibit B, to be
issued to such holders of CBH Common Stock Purchase Warrants.

            E. The  respective  Boards of Directors (or  committees  thereof) of
NeoStem,  Subco  and  CBH  have  determined  that  the  Merger,  in  the  manner
contemplated  herein, is desirable and in the best interests of their respective
stockholders  and, by resolutions  duly adopted,  have approved and adopted this
Agreement.

            NOW,  THEREFORE,  in  consideration of these premises and the mutual
and dependent promises hereinafter set forth, the parties hereto hereby agree as
follows:

                                   ARTICLE I.

                                   THE MERGER

      1.1 The Merger.  Upon the terms and subject to the conditions  hereof, and
in accordance with the provisions of the Delaware  General  Corporation Law (the
"DGCL"),  CBH shall be merged with and into Subco at the  Effective  Time.  As a
result of the Merger,  the separate existence of CBH shall cease and Subco shall
continue its existence  under the laws of the State of Delaware.  Subco,  in its
capacity as the limited  liability  company surviving the Merger, is hereinafter
sometimes referred to as the "Surviving Company."


                                      -2-


      1.2  Effective  Time.  As promptly  as  possible  on the Closing  Date (as
defined herein),  the parties shall cause the Merger to be consummated by filing
with the Secretary of State of the State of Delaware (the "Delaware Secretary of
State") a certificate of merger (the "Certificate of Merger") in such form as is
required  by  Section  18-209 of the  Delaware  Limited  Liability  Company  Act
("DLLCA")  and executed in  accordance  with the DLLCA.  The Merger shall become
effective (the  "Effective  Time") when the Certificate of Merger has been filed
with the Delaware  Secretary  of State,  which filing shall occur on the Closing
Date,  or at such  later  time as shall be agreed  upon by  NeoStem  and CBH and
specified in the Certificate of Merger.  Prior to the filing referred to in this
Section  1.2,  a  closing  (the  "Closing")  shall  be  held at the  offices  of
Lowenstein Sandler PC, 65 Livingston Avenue,  Roseland, New Jersey 07068 or such
other place as the parties may agree,  as soon as practicable  (but in any event
within five Business Days (as defined herein)) following the date upon which all
conditions  set forth in Article V hereof have been  satisfied or waived,  or at
such other date as NeoStem and CBH may agree,  provided that the  conditions set
forth in Article V have been  satisfied or waived at or prior to such date.  The
date on which the Closing  takes  place is  referred  to herein as the  "Closing
Date." For all tax  purposes,  the Closing  shall be effective at the end of the
day on the Closing Date. For purposes of this Agreement, the term "Business Day"
means a day, other than a Saturday or Sunday,  on which  commercial banks in New
York City are open for the general transaction of business.

      1.3 Effects of the Merger.  From and after the Effective  Time, the Merger
shall have the effects set forth in Section 18-209(g) of the DLLCA.

      1.4  Certificate  of Formation and Operating  Agreement.  At the Effective
Time,  (i) the  certificate  of formation of the Surviving  Company as in effect
immediately  prior to the  Effective  Time shall be amended as of the  Effective
Time so as to  contain  the  provisions,  and  only  the  provisions,  contained
immediately  prior thereto in the certificate of formation of Subco,  except for
Article  FIRST  thereof  which may be revised to change the name of the  limited
liability  company as  mutually  agreed to by the parties  hereto,  and (ii) the
limited liability company agreement of Subco in effect  immediately prior to the
Effective Time shall be the limited liability company agreement of the Surviving
Company; in each case until amended in accordance with applicable law.

      1.5  Managers and Officers of the  Surviving  Company.  From and after the
Effective  Time,  individuals  designated by NeoStem prior to the Effective Time
shall be the officers of the  Surviving  Company and the  managers of Subco,  if
any,  shall be the managers of the Surviving  Company,  in each case until their
respective successors are duly elected and qualified. On or prior to the Closing
Date, CBH shall deliver to NeoStem a written resignation,  in form and substance
satisfactory to NeoStem,  from each director and officer of CBH, effective as of
the Effective Time.


                                      -3-


                                  ARTICLE II.

                    CONVERSION AND DISTRIBUTION OF SECURITIES

      2.1 Conversion of Capital Stock.  At the Effective  Time, by virtue of the
Merger  and  without  any action on the part of  NeoStem,  Subco or CBH or their
respective stockholders or members, as the case may be:

            2.1.1 Each  membership  interest  of Subco  issued  and  outstanding
immediately  prior to the  Effective  Time shall be converted  into a membership
interest of the Surviving  Company.  Such membership  interests shall thereafter
constitute all of the issued and outstanding equity of the Surviving Company, so
that NeoStem  shall own all of the  membership  interests in, and equity of, the
Surviving Company.

            2.1.2 Subject to the other provisions of this Article II, all of the
shares of CBH Common  Stock  issued  and  outstanding  immediately  prior to the
Effective Time shall be converted into the right to receive in the aggregate all
of the  Exchanged  Common  Shares so that all of the holders of CBH Common Stock
(inclusive  of any CBH Common Stock issued upon exercise of any CBH Common Stock
Purchase  Warrants)  shall be  entitled to receive  7,500,000  shares of NeoStem
Common Stock in the aggregate (of which 150,000 shares shall be delivered to the
Escrow Agent to be held in escrow  pursuant to the Escrow  Agreement  annexed as
Exhibit D).

            2.1.3 Each share of capital stock of CBH held in the treasury of CBH
shall be canceled and retired and no payment shall be made in respect thereof.

            2.1.4 All of the shares of CBH Series B Preferred  Stock  issued and
outstanding  immediately prior to the Effective Time shall be converted into all
of the RimAsia Exchanged  Securities  subject to cancellation of the RimAsia CBH
Warrants as specified in Section 2.2.1.

            2.1.5 Dissenting  Shares (as defined herein) shall, by virtue of the
Merger,  be cancelled and  extinguished  and converted into the right to receive
payment  provided  for by  Section  262 of the  DGCL,  in  accordance  with  the
provisions of Section 2.5.

      2.2 Distributions; Exchange Ratio; Fractional Shares; Adjustments.

            2.2.1  Pursuant to a CBH Lock-Up and Voting  Agreement,  dated as of
the date hereof,  among RimAsia, the CBH Preferred  Stockholders,  each director
and officer of each of CBH, CBH, Erye, EET, Dr. Wang Taihua and NeoStem,  a copy
of  which  is  attached  hereto  as  Exhibit  C (the  "CBH  Lock-Up  and  Voting
Agreement"),  RimAsia has  consented to the treatment set forth in Section 2.1.4
above and agreed,  upon the  effectiveness  of the Merger,  to cancel the Common
Stock  Purchase  Warrant to purchase up to 12 million shares of CBH Common Stock
issued to RimAsia on June 30, 2006 and modified on November 16, 2007  ("Modified
Warrants"),  and the Additional  Common Stock Purchase Warrants (No. R-2) issued
to RimAsia on November 16, 2007 ("Additional Warrants, and collectively with the
Modified Warrants,  the "RimAsia CBH Warrants") and exchange all of its interest
in CBH,  including  but not limited to all of the CBH Series B  Preferred  Stock
outstanding for the RimAsia Exchanged Securities.


                                      -4-



            2.2.2 Pursuant to the CBH Lock-Up and Voting Agreement,  the holders
of the CBH Series A Preferred Stock have consented to the Merger and have agreed
to cancel  and  cause to be  terminated  such  holders'  shares of CBH  Series A
Preferred  Stock as set forth in Section 2.7 and to cancel any CBH Warrants held
by such holders.

            2.2.3 As soon as practical  after the  effectiveness  of the Merger,
each  holder of CBH Common  Stock  shall  receive,  for each share of CBH Common
Stock held by such CBH  common  shareholder,  a  fraction  of a share of NeoStem
Common Stock equal to the Exchange Ratio (as defined herein).

            2.2.4  The  "Exchange  Ratio"  shall  be equal  to the  quotient  of
7,350,000  divided by the sum of (x) the  number of shares of CBH  Common  Stock
outstanding  at the Effective  Time,  and (y) the number of shares of CBH Common
Stock issuable upon exercise of in-the-money  warrants of CBH immediately  prior
to the Effective  Time subject to  adjustment  as set forth  herein.  Any Escrow
Shares  shall be  distributed  pro rata to the same record  shareholders  as the
initial distribution.

            2.2.5 No certificates for fractional  shares of NeoStem Common Stock
shall be issued as a result of the  distribution  provided for in Section 2.2.3.
In lieu of any fractional share to which the CBH Stockholders would otherwise be
entitled as a result of the  distribution  provided  for in Section  2.2.3,  all
issuances  of NeoStem  Common  Stock  shall be rounded up to the  nearest  whole
share.

            2.2.6 In the event that,  subsequent to the date hereof and prior to
the  Effective  Time,  NeoStem or CBH shall  declare a stock  dividend  or other
distribution  payable in shares of NeoStem  Common  Stock or CBH Common Stock or
securities  convertible  into shares of NeoStem Common Stock or CBH Common Stock
or effect a stock  split,  reclassification,  combination  or other  change with
respect to shares of NeoStem  Common  Stock or CBH Common  Stock,  the  Exchange
Ratio set forth in Section  2.2.4 shall be adjusted  to reflect  such  dividend,
distribution, stock split, reclassification, combination or other change.

            2.2.7 In the event that,  subsequent to the date hereof and prior to
the Effective  Time,  CBH or Erye shall incur any  liabilities or obligations of
any nature, whether absolute,  accrued,  unmatured,  contingent or otherwise, or
any  unsatisfied  judgments or any leases of  personalty or realty or unusual or
extraordinary commitments,  other than those liabilities or allowances recorded,
accrued or  reserved  against on the CBH Balance  Sheet (as  defined  herein) or
described in the notes thereto,  such liabilities or obligations  shall be paid,
satisfied or otherwise  provided for or transferred to CBC prior to the Spin-Off
in accordance with Section 5.17.1.

      2.3 Exchange of Certificates.

            2.3.1 Exchange Agent. Promptly following the Effective Time, NeoStem
shall  deposit with  Continental  Stock  Transfer & Trust  Company or such other
exchange agent as may


                                      -5-


be  designated  by  NeoStem  (the  "Exchange  Agent"),  for the  benefit  of CBH
Stockholders, for distribution in accordance with this Section 2.3, certificates
representing 7,500,000 shares of the Exchanged Common Shares for distribution to
holders of outstanding shares of CBH Common Stock pursuant to Section 2.2.3.

            2.3.2  Exchange  Procedures.   As  soon  as  practicable  after  the
Effective  Time, CBH shall instruct the Exchange Agent to mail to each holder of
record of a certificate or certificates which immediately prior to the Effective
Time  represented  outstanding  shares of CBH Common  Stock,  a  certificate  or
certificates  for the Exchanged  Common Shares in the pro rata amounts  provided
for in this Section 2.3.

            2.3.3   Distributions   with   Respect  to  CBH   Preferred   Stock.
Simultaneously  with the  consummation  of the Merger,  RimAsia shall cancel the
RimAsia CBH  Warrants and all its  outstanding  shares of CBH Series B Preferred
Stock shall be cancelled. In exchange,  NeoStem will issue the RimAsia Exchanged
Securities to RimAsia as set forth in Section 2.2.1.

            2.3.4  Erye.  At the  Closing,  CBH shall  deliver to NeoStem a duly
executed  assignment of its Erye  Ownership,  consented to by Erye and the other
49% equity  holder in Erye.  CBH  represents  and warrants  that  following  the
Merger, NeoStem will have the Erye Ownership, and will have unfettered access to
the Minimum Cash.

      2.4 Treatment of Warrants. At the Effective Time, subject to acceptance by
the holders of CBH Common Stock Purchase Warrants, the CBH Common Stock Purchase
Warrants  shall be  canceled  and the  holders  thereof  shall  receive,  in the
aggregate,  Class C Warrants to purchase up to an aggregate of 2,012,097  shares
of NeoStem  Common Stock at an exercise price of $2.50 per share pursuant to the
Class C Warrant  Agreement.  Notwithstanding  anything  contained  herein to the
contrary,  if and to the extent NeoStem determines,  in its sole discretion,  to
waive the condition to NeoStem's obligation to consummate the Merger that all of
the holders of CBH Common  Stock  Purchase  Warrants  accept Class C Warrants in
exchange for their  respective  CBH Common Stock  Purchase  Warrant set forth in
Section 6.2.20,  then any holder of CBH Common Stock Purchase Warrants that does
not accept  Class C Warrants  in exchange  for such  holder's  CBH Common  Stock
Purchase  Warrants,  upon  consummation of the Merger,  shall be entitled to the
rights under the CBH Common Stock Purchase Warrants held by such holder.

      2.5 Escrow Shares. At the Closing, NeoStem shall issue an aggregate amount
of 200,000  shares of  NeoStem  Common  Stock to CBC in escrow as a  conditional
bonus payment if introductions  with respect to the Shangdong  Institute made by
CBC to NeoStem result NeoStem's  acquisition of the Shangdong Institute prior to
the six month  anniversary  of the Closing  (together with the 150,000 shares of
the Common Stock  provided in  Preliminary  Statement  E(1),  collectively,  the
"Escrow   Shares").   The  certificates  for  the  Escrow  Shares  (the  "Escrow
Certificates")  shall be deposited with an escrow agent to be mutually agreed to
by NeoStem and CBC prior to the Closing (the "Escrow  Agent").  The Certificates
shall be held and  disbursed  by the  Escrow  Agent  pursuant  to the  terms and
conditions of an Escrow  Agreement,  in the form  attached  hereto as Exhibit D,
subject  to such  modifications  thereof as the Escrow  Agent  shall  reasonably
request  prior to the Closing and as shall be accepted by CBC and NeoStem  (such
acceptance  not  to  be  unreasonably  denied)  (as  so  modified,  the  "Escrow
Agreement").


                                      -6-


      2.6 Dissenting Shares.  Notwithstanding  anything in this Agreement to the
contrary,  shares of CBH Common  Stock and CBH  Preferred  Stock held by holders
thereof  who are  entitled  to vote on the  Merger  and who have not voted  such
shares  in favor of the  adoption  of this  Agreement  and the  Merger  and with
respect  to which  appraisal  rights  shall  have been  properly  exercised  and
perfected in accordance with Section 262 of the DGCL (the "Dissenting  Shares"),
shall not be  converted  into or  represent  the  right to  receive  the  Merger
Consideration  which the holders of CBH Common Stock and CBH Preferred Stock are
entitled to receive  pursuant to Sections 2.1 through 2.3 above,  and holders of
such  Dissenting  Shares shall be entitled to receive only the payment  provided
for by Section 262 of the DGCL unless and until such  holders fail to perfect or
effectively  withdraw or otherwise lose their rights to demand payment under the
DGCL.  If,  after the  Effective  Time,  any such  holder  fails to  perfect  or
effectively  withdraws  or  loses  such  right,  such  Dissenting  Shares  shall
thereupon be deemed to be "Non-Electing  Company Shares." CBH shall give NeoStem
(i) prompt notice of any demands for payment for Dissenting  Shares  pursuant to
Section 262 of the DGCL received by CBH,  withdrawals  of such demands,  and any
other  instruments  served pursuant to the DGCL and received by CBH and (ii) the
opportunity to direct all  negotiations  and proceedings with respect to demands
for payment  pursuant to Section 262 of the DGCL. CBH shall not, except with the
prior written  consent of NeoStem or as otherwise  required by  Applicable  Law,
make any payment with respect to any such demands for payment or offer to settle
or settle any such demands.  Notwithstanding  anything in this  Agreement to the
contrary,  NeoStem,  at the election of its Board of  Directors  (or a committee
thereof),  in its sole  discretion,  may terminate and abandon this Agreement at
any time prior to the Closing if the Dissenting  Shares represent more than five
(5%) of the shares of CBH Common  Stock or CBH  Preferred  Stock held by holders
thereof who are entitled to vote on the Merger.

      2.7  Satisfaction  of Certain  CBH  Obligations.  At the  Effective  Time,
NeoStem shall issue to Stephen E. Globus,  a director of CBH or related  persons
("Globus") 50,000 shares of NeoStem Common Stock in exchange for cancellation of
all of the shares of CBH Series A Preferred  Stock held by Globus  (which Globus
and CBH have represented to NeoStem are all of the outstanding  shares of Series
A Preferred  Stock).  NeoStem shall also issue 60,000  shares of NeoStem  Common
Stock to Globus and 40,000 shares of NeoStem Common Stock to Chris Peng Mao, the
Chief  Executive  Officer of CBH  ("Mao")  (an  aggregate  of 150,000  shares of
NeoStem Common Stock being issued pursuant to this paragraph) at or prior to the
Closing,  in exchange for the  cancellation  and the satisfaction in full of the
Globus  Obligation  and the Mao Obligation  (each,  as defined in Section 6.2.21
herein).  CBH and Globus  shall cause all of the  outstanding  shares of the CBH
Series  A  Preferred  Stock  to  be  cancelled  and  terminated  no  later  than
immediately  prior to the record date for any  shareholder  vote with respect to
the Merger.  The "Globus  Shares" shall be allocated  among  related  persons in
accordance  with  written  instructions  to be provided to NeoStem by Globus and
certified by him.


                                      -7-


                                  ARTICLE III.

                      REPRESENTATIONS AND WARRANTIES OF CBH

            Except as set forth in the disclosure  statement delivered by CBH to
NeoStem at or prior to the  execution  of this  Agreement  (the "CBH  Disclosure
Statement")  (each  section  of which  qualifies  the  correspondingly  numbered
representation  and  warranty,  regardless  of whether  such  representation  or
warranty expressly refers to or is qualified by reference to such CBH Disclosure
Statement),  or  disclosed  in the CBH SEC  Reports  (as  defined  herein),  CBH
represents and warrants to NeoStem and Subco as follows (it being understood and
agreed  that each  representation  and  warranty  with  respect  to any  payment
obligation of Erye that is qualified hereunder as to materiality, shall refer to
any such  obligation  (i)  having a dollar  value of more than  $50,000,  to the
extent such value is quantifiable, and (ii) not incurred or made in the ordinary
course of business):

      3.1 Organization and Qualification.

            3.1.1 Each of CBH and Erye is an entity duly  incorporated,  validly
existing  and in  good  standing  under  the  laws  of the  jurisdiction  of its
incorporation  and has the  corporate  power  and  authority  to own,  lease and
operate its  properties  and to conduct its business as described in the CBH SEC
Reports (as defined  herein),  except that as of the date hereof,  CBH is not in
good  standing  under the laws of Delaware but covenants to pay all taxes and be
in good  standing  prior to the filing of any  Registration  Statement  or Joint
Proxy Statement with the SEC. Each of CBH and Erye is duly qualified to transact
business  as a  foreign  corporation  or  other  foreign  entity  and is in good
standing  in each  jurisdiction  in which the  conduct  of its  business  or the
ownership,  leasing or operation of its property  requires  such  qualification,
except for  failures to be so  qualified  or in good  standing  which would not,
singly or in the  aggregate  with all such other  failures,  have a CBH Material
Adverse  Effect (as  defined  herein).  For  purposes  of this  Agreement,  "CBH
Material Adverse Effect" means, with respect to any event,  occurrence,  matter,
failure  of event or  occurrence,  change,  effect,  state of  affairs,  breach,
default, violation, fine, penalty or failure to comply (each, a "Circumstance"),
individually or taken together with all other  Circumstances  contemplated by or
in connection with any or all of the representations and warranties made in this
Agreement, a material adverse effect on the business,  assets (including without
limitation intangible assets), liabilities (contingent or otherwise),  financial
condition, results of operations or prospects of CBH and Erye, taken as a whole;
provided,  however,  that the term "CBH  Material  Adverse  Effect" shall not be
deemed to  include  the impact  of:  (A) the  implementation  of changes in U.S.
generally accepted  accounting  principles;  (B) actions and omissions of CBH or
its  Subsidiaries  taken or permitted with the prior written  consent of NeoStem
after  the  date  hereof;  (C)  expenses  reasonably  incurred  by  CBH  or  its
Subsidiaries in consummating  the  transactions  contemplated by this Agreement;
(D) changes in the general  economic or  financial  market  conditions;  (E) any
occurrence,  condition,  change, event or effect that affects the pharmaceutical
industry generally;  and (F) the outbreak or escalation of hostilities involving
the PRC or the United States, the declaration by the PRC or the United States of
war or the occurrence of any natural disasters and acts of terrorism.


                                      -8-


            3.1.2 Neither CBH nor any of its Subsidiaries is in violation of any
of the  provisions of its  certificate  of  incorporation  or by-laws,  or other
similar organizational  documents,  each as amended and currently in effect, or,
if it is a limited  liability company or partnership,  its operating  agreement,
partnership agreement or other comparable agreement. True and complete copies of
the certificate of incorporation  and by-laws,  each as amended and as currently
in  effect,  of  CBH,  and  true  and  complete  copies  of the  certificate  of
incorporation and by-laws, or other similar  organizational  documents,  each as
amended and currently in effect,  of each Subsidiary of CBH have been previously
delivered or made  available to NeoStem.  No  amendments to the  certificate  of
incorporation,  as  amended,  of CBH  have  been  authorized  since  2005 and no
amendments to the by-laws of CBH have been  authorized  since 2005. For purposes
of this Agreement,  all references to the "Subsidiaries" of CBH shall constitute
references  to any entity (i) the accounts of which would be  consolidated  with
those  of CBH in  CBH's  consolidated  financial  statements  if such  financial
statements  were  prepared in  accordance  with  generally  accepted  accounting
principles or (ii) of which securities or other ownership interests representing
more than 50% of the equity or more than 50% of the ordinary voting power or, in
the case of a partnership, more than 50% of the general partnership interests or
more than 50% of the  profits  or losses  are  owned by CBH  and/or  one or more
subsidiaries of CBH, and shall include, without limitation,  CBC, Nanjing Keyuan
Pharmaceutical R&D Co., Ltd., a Chinese company ("Nanjing Keyuan"), and Erye.

            3.1.3 Erye is a  Sino-Foreign  Joint Venture with limited  liability
organized under the laws of the PRC, duly incorporated,  validly existing and in
good  standing  under the laws of the PRC.  The  articles  of  association,  the
business  license  and  other  constituent  documents  of Erye  comply  with the
requirements  of  applicable  laws of the PRC and are in full force and  effect.
Erye has full  power and  authority  (corporate  and  other)  and all  consents,
approvals, authorizations, orders, registrations,  clearances and qualifications
of or with any local,  domestic,  foreign or multi-national  court,  arbitration
tribunal,   administrative  agency,   commission,   legislative  body  or  other
governmental  or  regulatory  body,   agency,   instrumentality   or  authority,
including,  without  limitation,  of the United States, the PRC, or otherwise (a
"Governmental Authority") having jurisdiction over Erye or any of its properties
required  for the  ownership  and the conduct of its  business and has the legal
right and authority to own, use, lease and operate its assets and to conduct its
business.  All of the issued  shares of capital  stock of Erye has been duly and
validly  authorized and issued and are fully paid and  non-assessable.  Erye has
obtained all approvals,  authorizations,  consents and orders,  and has made all
filings and registrations, which are required under PRC laws and regulations for
the  ownership  interest by CBH or NeoStem of its equity  interest in Erye;  and
there are no outstanding rights,  warrants or options to acquire, or instruments
convertible into or exchangeable for, nor any agreements or other obligations to
issue or other rights to convert any  obligation  into,  any equity  interest in
Erye.

      3.2  Authority  Relative  to this  Agreement.  (a) CBH and  Erye  have the
corporate  power and authority to execute and deliver this  Agreement  and, upon
obtaining the approval of a majority of the outstanding shares of the CBH Common
Stock and each of the CBH Series A Preferred  Stock and Series B Preferred Stock
of CBH (collectively,  the "CBH Preferred Stock") at the CBH Special Meeting (as
defined  herein) or any  adjournment  thereof as  authorized  under the DGCL, to
consummate  the  Merger  and the other  transactions  contemplated  hereby.  The
execution and delivery of this Agreement and the  consummation of the Merger and
the other transactions contemplated hereby have been duly and validly authorized
by the Boards of Directors of CBH and Erye and except as stated in the preceding
sentence,  no  other  corporate  proceedings  on the  part  of CBH or  Erye  are
necessary to authorize  this Agreement or to consummate the Merger and the other
transactions  contemplated  hereby.  This  Agreement  has been duly and  validly
executed  and  delivered  by  each  of  CBH  and  Erye  and,  assuming  the  due
authorization, execution and delivery hereof by NeoStem and Subco and subject to
stockholder approval as aforesaid,  constitutes a valid and binding agreement of
each of CBH and Erye enforceable against each of CBH and Erye in accordance with
its  terms,  except to the  extent  that its  enforceability  may be  limited by
applicable  bankruptcy,  insolvency,  reorganization,  moratorium  or other laws
affecting the enforcement of creditors' rights generally or by general equitable
principles.


                                      -9-


                  (b) As a result of the Merger,  the Surviving Company will own
of  record  the Erye  Ownership,  and  NeoStem  will  beneficially  own the Erye
Ownership,  free of all  Encumbrances  and free of all  governed or  contractual
restrictions.

                  (c) CBH has the  corporate  power and  authority to effect the
Spin-Off.  The consummation of the Spin-Off has been duly and validly authorized
by the  Board  of  Directors  of  CBH,  and  other  than  approval  by  the  CBH
Stockholders, no other corporate proceedings on the part of CBH are necessary to
authorize or consummate the Spin-Off.

      3.3 Consents, No Conflicts.

            3.3.1  Except  for  actions to be taken in  connection  with (a) the
filing of the Certificate of Merger required under DLLCA Section 18-209(c),  (b)
the filing and  effectiveness  of the  Registration  Statement  (as  hereinafter
defined),  (c) filings  required  pursuant to any state securities or "blue sky"
laws,  (d) filings and other  matters  relating to the listing or quoting on the
American Stock Exchange,  Inc., The New York Stock Exchange,  Inc. or The NASDAQ
Stock  Market  (each,  an  "Exchange")  of the  shares of NeoStem  Common  Stock
required to be issued  pursuant to this  Agreement,  and (e) any other  filings,
notices,  disclosures  or  registrations  set forth in Section  3.3.1 of the CBH
Disclosure Statement, no filing or registration with, notification or disclosure
to, or permit, authorization,  consent or approval of, (x) any U.S. Governmental
Authority or (y) any third party, whether acting in an individual,  fiduciary or
other  capacity,  is required for the  consummation  by CBH of the Merger or the
other  transactions  contemplated  hereby or for the ownership by NeoStem of the
Erye Ownership.

                                      -10-

            3.3.2  Except as set forth in  Section  3.3.2 of the CBH  Disclosure
Statement,  the  execution,  delivery and  performance of this Agreement and the
consummation of the Merger and the other  transactions  contemplated  hereby and
compliance  by CBH and Erye  with any of the  provisions  hereof do not and will
not: (i) subject to  obtaining  the approval of the Merger by holders of the CBH
Common Stock and the CBH Preferred Stock,  conflict with or result in any breach
or violation of any provision of the certificate of incorporation or by-laws, or
other similar  organizational  documents,  each as amended, of CBH or any of its
Subsidiaries  or (ii) result in (1) a breach or violation of, a default under or
an event  triggering any payment,  obligation or  acceleration of any obligation
pursuant to CBH Employee  Benefit Plan (as defined herein) or any grant or award
made under any of the  foregoing,  (2) a breach or violation of, a default under
or an event  triggering  a right of  termination  of, a  default  under,  or the
acceleration  of any  obligation  or the  creation of a lien,  pledge,  security
interest or other encumbrance on assets (with or without the giving of notice or
the lapse of time or both) pursuant to any provision of, any agreement, license,
lease  of  real or  personal  property,  marketing  agreement,  contract,  note,
mortgage,  indenture or other obligation of CBH or any of its Subsidiaries ("CBH
Contracts") or, subject to making all filings, notifications and disclosures and
receipt of all permits,  authorizations,  consents and approvals  referred to in
clauses  "a"  through  "e" of  Section  3.3.1  or in  Section  3.3.1  of the CBH
Disclosure  Statement,  any law,  rule,  ordinance  or  regulation  or judgment,
decree, order or award to which CBH or any of its Subsidiaries is subject or any
governmental or non-governmental authorization, consent, approval, registration,
franchise, license or permit under which CBH or any of its Subsidiaries conducts
any of its business, or (3) any other change in the rights or obligations of any
party under any of the CBH Contracts,  except, with respect to this clause (ii),
for breaches, violations, defaults, triggering events, creations of Encumbrances
on assets, or changes in rights or obligations which would not, singly or in the
aggregate with all other such matters, have a CBH Material Adverse Effect.

            3.3.3  Except as disclosed  on Section  3.3.3 of the CBH  Disclosure
Statement,  Erye (a) is not in  conflict  with or in  violation  or breach of or
default under (and there exists no event that, with notice or passage of time or
both,  would  constitute a conflict,  violation,  breach or default  with, of or
under) (i) any Law applicable to it or any of its properties, assets, operations
or business,  (ii) any provision of its certificate of incorporation or by-laws,
or other similar organizational  documents,  each as amended, except in the case
of the  foregoing  clauses  (i) and  (iii)  for any  such  conflicts,  breaches,
violations and defaults that,  individually or in the aggregate,  could not have
or result in a CBH  Material  Adverse  Effect.  Except for the  approval  of the
competent  authorities  of commerce under the Law on  Sino-Foreign  Equity Joint
Ventures and its implementation regulations, no PRC Government Approval or other
consent  is  required  to be  obtained  or made by Erye in  connection  with the
execution and delivery of this  Agreement or the  consummation  of the Merger or
other transactions contemplated hereby.

      3.4 Board  Recommendation.  The Boards of  Directors  of CBH and the board
member  representatives  from Erye have, each, by a unanimous written consent on
November 2, 2008, approved and adopted this Agreement,  the Merger and the other
transactions  contemplated hereby. In such resolutions,  the Boards of Directors
of CBH and the  board  member  representatives  from  Erye  determined  that the
consideration  to be received by holders of CBH Common  Stock and CBH  Preferred
Stock  pursuant  to the  Merger is fair to the  holders  of shares of CBH Common
Stock and CBH Preferred Stock, respectively, and recommended that the holders of
such  shares  approve  and  adopt  this  Agreement,  the  Merger  and the  other
transactions contemplated hereby (the "CBH Board Recommendation").

      3.5  State   Anti-takeover   Statutes;   Stockholder   Protection   Rights
Agreements.  By virtue of  resolutions  heretofore  approved by CBH's and Eyre's
Boards of  Directors,  the Merger,  this  Agreement,  the CBH Lock-Up and Voting
Agreement,  the  Support  Agreement  (as defined  herein)  and the  transactions
contemplated  hereby  will  not be  subject  to  the  restrictions  on  business
combinations with interested  stockholders  otherwise  applicable to the Merger,
this Agreement,  the CBH Lock-Up and Voting Agreement,  the Support Agreement or
the transactions  contemplated hereby under Section 203 of the DGCL. CBH's Board
of Directors  have taken such actions and votes as are  necessary on its part to
render the provisions of Section 203 of the DGCL, all other applicable  takeover
statutes of the DGCL inapplicable to this Agreement, the Merger, the CBH Lock-Up
and Voting Agreement,  the Support  Agreement and the transactions  contemplated
hereby  and  thereby.  Neither  CBH  nor  Erye  is a  party  to any  stockholder
protection rights agreement or any agreement similar thereto.


                                      -11-



      3.6 No Existing Violation,  Default,  Etc. None of CBH or its Subsidiaries
is in violation of (A) any Applicable  Law or (B) any order,  decree or judgment
of  any  Governmental  Authority  having  jurisdiction  over  CBH  or any of its
Subsidiaries. No event of default or event that, but for the giving of notice or
the lapse of time or both,  would  constitute an event of default,  exists under
any CBH Contract or any lease, permit,  license or other agreement or instrument
to which  CBH or any of its  Subsidiaries  is a party or by which any of them is
bound or to which any of the  properties,  assets or operations of CBH or any of
its Subsidiaries is subject.

      3.7  Licenses  and  Permits.  Each of CBH and Erye has such  certificates,
permits, licenses,  franchises,  consents, approvals, orders, authorizations and
clearances from appropriate governmental agencies and bodies ("CBH Licenses") as
are  necessary  to own,  lease or operate  its  properties  and to  conduct  its
business  in the  manner  described  in the CBH  SEC  Reports  and as  presently
conducted  and all such CBH  Licenses  are valid and in full  force and  effect,
other than any  failure to have any such CBH  License or any failure of any such
CBH License to be valid and in full force and effect as would not,  singly or in
the aggregate with all such other failures,  have a CBH Material Adverse Effect.
Each of CBH and Erye is and,  within the period of all  applicable  statutes  of
limitations, has been in compliance with its obligations under such CBH Licenses
and no event has occurred  that  allows,  or after notice or lapse of time would
allow,  revocation or termination of such CBH Licenses. Each of CBH and Erye has
no knowledge of any facts or circumstances  that could reasonably be expected to
result in an inability of CBH or any of its  Subsidiaries  to renew any material
CBH License.  Subject to making all filings,  notifications  and disclosures and
receipt of all permits,  authorizations,  consents and approvals  referred to in
Section  3.3.1  of the CBH  Disclosure  Statement,  neither  the  execution  nor
delivery  by  CBH  of  this  Agreement  nor  the  consummation  of  any  of  the
transactions contemplated herein will result in any revocation or termination of
any material CBH License.

      3.8 Registration Statement;  Prospectus/Joint Proxy Statement. None of the
information supplied or to be supplied by CBH, Erye or CBC for inclusion in, and
none of the  information  regarding  CBH and its  Subsidiaries  incorporated  by
reference in, the  registration  statement  under the Securities Act registering
the NeoStem  Common Stock to be issued  pursuant to the Merger and the shares of
common stock,  par value $1.00 per share,  of CBC (the "CBC Common Stock") to be
issued pursuant to the Spin-Off (such registration  statement, as amended by any
amendments thereto, being referred to herein as the "Registration Statement") or
the  prospectus/joint  proxy statement to be sent to the stockholders of NeoStem
and CBH in  connection  with the annual  meeting of  stockholders  of NeoStem at
which such  stockholders will be asked to approve the issuance of NeoStem Common
Stock  pursuant to the Merger (the  "NeoStem  Annual  Meeting")  and the special
meeting of the stockholders of CBH at which such  stockholders  will be asked to
approve the Spin-Off,  the Merger and this Agreement (the "CBH Special Meeting")
(such  prospectus/joint  proxy statement,  as amended by any amendments thereto,
being referred to herein as the "Prospectus/Joint  Proxy Statement"),  including
all   amendments   and   supplements   to   the   Registration   Statement   and
Prospectus/Joint  Proxy  Statement,  shall,  in the  case  of  the  Registration
Statement,  at the time the Registration Statement becomes effective and, in the
case  of  the  Prospectus/Joint  Proxy  Statement,  on the  date  or  dates  the
Prospectus/Joint Proxy Statement is first mailed to NeoStem and CBH stockholders
and on the date or dates  of the  NeoStem  Annual  Meeting  and the CBH  Special
Meeting,  contain  any untrue  statement  of a material  fact or omit to state a
material  fact  required to be stated  therein or necessary in order to make the
statements  therein,  in the light of the  circumstances  under  which they were
made,  not  misleading.  CBH and Erye will  supply  NeoStem  with all  business,
financial,  legal,  management and other information required for inclusion in a
Form S-4 under SEC rules.


                                      -12-



      3.9 Finders or  Brokers;  Compensation  Arrangements.  Neither CBH nor any
Subsidiary  of CBH  has  employed  any  investment  banker,  broker,  finder  or
intermediary in connection with the transactions  contemplated  hereby who might
be entitled to a fee or any  commission  the receipt of which is  conditioned in
whole or part upon consummation of the Merger.

      3.10 SEC Reports.  CBH has filed all forms, reports and documents required
to be filed by it with the SEC since  December  31, 2007 (the "CBH Audit  Date")
(including,  without limitation, CBH's Annual Report on Form 10-KSB for the year
ended  December  31,  2007 and  CBH's  Quarterly  Reports  on Form  10-Q for the
quarters  ended  March 31,  2008 and June 30,  2008 and all  certifications  and
statements  required by Rule 13a-14 or 15d-14 under the Securities  Exchange Act
of 1934, as amended (the "Exchange Act") or 18 U.S.C.  Section 1350 (Section 906
of the Sarbanes-Oxley Act of 2002 ("SOX")) with respect to any Annual Reports or
Proxy  Statements,  and  Current  Reports on Form 8-K),  pursuant to the federal
securities laws and the SEC's rules and regulations thereunder,  and SOX and all
rules and  regulations  thereunder  (collectively,  and together with all forms,
reports  and  documents  filed by CBH  with the SEC  after  December  31,  2007,
including any amendments thereto,  the "CBH SEC Reports").  CBH SEC Reports were
or will, as applicable,  be prepared in accordance with the  requirements of the
Securities  Act and the  Exchange  Act,  as the case may be,  and the  rules and
regulations  thereunder.  As of their respective dates, none of CBH SEC Reports,
including,  without limitation,  any financial  statements or schedules included
therein,  contained or will contain,  as applicable,  any untrue  statement of a
material fact or omitted to state a material fact required to be stated  therein
or  necessary  in  order  to  make  the  statements  therein,  in  light  of the
circumstances  under  which  they were or are made,  as  applicable,  made,  not
misleading.  No  Subsidiary  of CBH is or has been  required  to file any  form,
report, registration statement or other document with the SEC.

      3.11 Disclosure Controls and Procedures. CBH maintains disclosure controls
and  procedures  required by Rule 13a-15 or 15d-15 under the Exchange  Act. Such
controls and  procedures  are effective to ensure that all material  information
concerning  CBH and its  Subsidiaries  is made  known on a  timely  basis to the
individuals  responsible  for the  preparation of CBH's filings with the SEC and
other public disclosure documents. As used in this Section 3.11, the term "file"
shall be  broadly  construed  to  include  any  manner  in which a  document  or
information is furnished, supplied or otherwise made available to the SEC.


                                      -13-


      3.12 Financial Statements. The consolidated balance sheets and the related
consolidated  statements of income and cash flows  (including  the related notes
thereto) of CBH included in CBH SEC Reports,  as of their  respective  dates and
the consolidated  balance sheets and related  consolidated  statements of income
and cash  flows of Erye  annexed  hereto as Section  3.12 of the CBH  Disclosure
Statement (the "Erye Financial  Statements"),  complied in all material respects
with applicable accounting  requirements and the published rules and regulations
of the SEC with respect thereto, were prepared in accordance with U.S. generally
accepted accounting  principles applied on a basis consistent with prior periods
(except  as  otherwise  noted  therein),  and  present  fairly  in all  material
respects,  the  consolidated  financial  position  of CBH and  its  consolidated
Subsidiaries or Erye, as the case may be, as of their respective  dates, and the
consolidated  results of their  operations  and their cash flows for the periods
presented  therein  (subject,  in the case of the  unaudited  interim  financial
statements,  to notes and normal year-end  adjustments that were not material in
amount or effect).

      3.13  SOX  Certifications.  The  Chief  Executive  Officer  and the  Chief
Financial  Officer of CBH have  signed,  and CBH has  furnished  to the SEC, all
certifications  required by  Sections  302 and 906 of SOX.  Such  certifications
contain no  qualifications  or exceptions to the matters  certified  therein and
have not been  modified or  withdrawn.  Neither  CBH nor any of it officers  has
received notice from any Governmental  Authority  questioning or challenging the
accuracy,  completeness,  form  or  manner  of  filing  or  submission  of  such
certifications.

      3.14  Undisclosed  Liabilities.  Except (i)as may be disclosed on Schedule
3.14(a) or 3.14(b) of the CBH Disclosure  Statement,  (ii) as reflected in CBH's
unaudited  consolidated balance sheet at June 30, 2008 or liabilities  described
in any notes thereto,  (iii) for liabilities  incurred in the ordinary course of
business since June 30, 2008 consistent with past practice or in connection with
this Agreement or the  transactions  contemplated  hereby,  or (iv)  performance
obligations  under  contracts  required  in  accordance  with  their  terms,  or
performance  obligations,  to the extent required under applicable laws, in each
case to the extent  arising  after the date  hereof,  neither CBH nor any of its
Subsidiaries has any material  liabilities or obligations of any nature (whether
accrued,  absolute,  contingent or otherwise) and which,  individually or in the
aggregate,  could  reasonably be expected to have a CBH Material Adverse Effect.
Set forth in Schedule  3.14(a) of the CBH  Disclosure  Statement are any and all
material   liabilities  and  obligations  of  Erye   (collectively,   the  "Eyre
Liabilities"),  as of November 2, 2008. Set forth in Schedule 3.14(b) of the CBH
Disclosure  Statement  are any and all  payable  obligations  of CBH  and/or its
Subsidiaries  (other than the Erye  Liabilities  as of November 2, 2008,  )("CBH
Payable  Obligations"),  excluding the expenses  incurred in connection with the
transactions  contemplated by this Agreement (the "Transaction  Expenses," which
is set forth in Schedule  3.14(c) of the CBH  Disclosure  Statement and shall be
approximately similar to NBS's transaction  expenses),  and the name and address
of each Person to whom each such  liability or obligation is owed, and CBH shall
take any and all  action  necessary  or  appropriate  to obtain a CBH  Liability
Release (as  defined  herein)  from each CBH  Creditor  (as  defined  herein) in
accordance with Section 5.17. To the best of knowledge of CBH and as of the date
of this Agreement,  the CBH Payable Obligations set forth in Schedule 3.14(b) of
the CBH Disclosure  Statement,  excluding the Transaction  Expenses,  do not and
shall not exceed, individually or in the aggregate, $450,000.


                                      -14-


      3.15 Off-Balance  Sheet  Arrangements.  CBH and its Subsidiaries  have not
effected any securitization transactions or "off-balance sheet arrangements" (as
defined in Item 303(c) of  Regulation  S-K of the SEC) since the CBH Audit Date.
CBH has  delivered  or made  available  to NeoStem  copies of the  documentation
creating or governing any such securitization transactions and off-balance sheet
arrangements.

      3.16 Loans to Executives and  Directors.  CBH has not, since the effective
date of SOX,  extended or  maintained  credit,  arranged  for the  extension  of
credit,  or renewed an extension of credit, in the form of a personal loan to or
for  any  director  or  executive  officer  (or  equivalent  thereof)  of CBH in
violation  of SOX. CBH has not made any loan or extension of credit to which the
second sentence of Section 13(k)(I) of the Exchange Act applies.

      3.17  Independent  Auditors.  Moore  Stephens  Wurth Frazer & Torbet,  LLP
serves as CBH's and Erye's independent  registered public accounting firm and to
CBH's knowledge,  there are no  relationships or services,  or any other factors
that may affect the objectivity and  independence of Moore Stephens Wurth Frazer
& Torbet, LLP under applicable auditing standards. Moore Stephens Wurth Frazer &
Torbet,   LLP  has  not  performed  any  non-audit  services  for  CBH  and  its
Subsidiaries since the CBH Audit Date, which, in any such case, were required to
be disclosed in CBH SEC Reports and were not so disclosed.

      3.18  Absence  of  Changes or  Events.  Except  for (a)  matters  publicly
disclosed by CBH prior to the date hereof in CBH SEC Reports  filed prior to the
date hereof, and (b) the settlement of the litigation in Hong Kong and Canada by
RACP Pharmaceutical  Holdings Limited, a wholly-owned subsidiary of CBC, against
Li Xiaobo and certain other  defendants in connection  with the  acquisition  of
shares of Enshi International (Holdings) Pte Ltd (the "LXB Litigation").

            3.18.1 Since  December 31, 2007: (i) CBH and its  Subsidiaries  have
conducted  their  business in the ordinary  course and have not entered into any
material oral or written agreement or other material  transaction that is not in
the  ordinary  course of  business  (other  than this  Agreement)  or that could
reasonably be expected to result in a CBH Material Adverse Effect;  (ii) neither
CBH nor any of its Subsidiaries have sustained any material loss or interference
with their business or properties from fire, flood, windstorm,  accident, strike
or other calamity (whether or not covered by insurance); (iii) there has been no
material change in the  indebtedness of CBH and its  Subsidiaries,  no change in
the capital stock of CBH and no dividend or  distribution  of any kind declared,
paid or made by CBH on any class of its  capital  stock;  (iv) there has been no
event or  condition  which has caused a CBH  Material  Adverse  Effect,  nor any
development,  occurrence  or state of facts or  circumstances  known to CBH that
could,  singly or in the  aggregate,  reasonably  be expected to result in a CBH
Material  Adverse  Effect;  and (v) there has been no material  change by CBH or
Erye in its accounting principles, practices or methods.


                                      -15-


            3.18.2 Since December 31, 2007, other than in the ordinary course of
business  consistent with past practice,  there has not been any increase in the
compensation or other benefits payable,  or which could become payable,  by CBH,
to its officers or key  employees,  or any  amendment of any of the CBH Employee
Benefit Plans.

      3.19 Capitalization.

            3.19.1  The  authorized  capital  stock of CBH  consists  solely  of
200,000,000  shares of CBH's common  stock,  par value $0.01 per share (the "CBH
Common Stock"),  and 10,000,000 shares of CBH's preferred stock, par value $0.01
per share,  of which  1,152,500  shares are  designated  as Series A Convertible
Preferred  Stock (the "CBH Series A Preferred  Stock") and 6,185,607  shares are
designated as Series B Convertible  Preferred Stock (the "CBH Series B Preferred
Stock" and  together  with the CBH Series A Preferred  Stock the "CBH  Preferred
Stock").  As of October 31,  2008,  there were  37,082,313  shares of CBH Common
Stock, and only 50,000 shares of CBH Series A Preferred Stock, all of which were
held by Globus,  still  outstanding  and shall be cancelled  pursuant to Section
2.7, and 6,653,656  shares of CBH Series B Preferred Stock  outstanding,  and no
shares  of CBH  Common  Stock,  CBH  Series A  Preferred  Stock or CBH  Series B
Preferred  Stock were held in CBH's  treasury.  There have been no  issuances of
capital stock of CBH since October 31, 2008. As of October 31, 2008,  10,400,401
shares of CBH Common  Stock  were  issuable  upon the  exercise  of  outstanding
warrants (collectively,  the "CBH Warrants") in addition to the shares of common
stock issuable upon exercise of outstanding RimAsia CBH Warrants, and no options
to purchase shares of capital stock of CBH were  outstanding,  no other warrants
or options are  outstanding;  and no shares of CBH Common Stock are reserved for
issuance  for any  purpose  other than upon  exercise  of such  outstanding  CBH
Warrants and RimAsia CBH Warrants.  A true and complete list of each CBH Warrant
outstanding  as of October 31, 2008 and with respect to each such  warrant,  the
name of the holder thereof,  the number of shares of CBH Common Stock underlying
such CBH Warrant, the exercise price and the expiration date is set forth in the
Registration Statement on Form SB-2 of CBH (File No. 333-132693) initially filed
with the SEC on March 24, 2006, as amended on May 3, 2006, and the  Registration
Statement on Form SB-2 of CBH (File No.  333-134727)  filed with the SEC on June
5, 2006.  Since October 31, 2008, no CBH Warrants or options to purchase  shares
of capital stock of CBH have been granted and no agreements or commitments  have
been made to grant any CBH Warrants or any options. Except for the foregoing and
the RimAsia CBH Warrants, there are not any existing options,  warrants,  calls,
subscriptions, or other rights or other agreements or commitments obligating CBH
to  issue,  transfer  or sell any  shares of  capital  stock of CBH or any other
securities  convertible  into or evidencing  the right to subscribe for any such
shares.  There are no outstanding stock appreciation  rights with respect to the
capital stock of CBH. All issued and outstanding  shares of CBH Common Stock and
CBH  Preferred  Stock are duly  authorized  and validly  issued,  fully paid and
nonassessable  and have  not been  issued  in  violation  of (nor are any of the
authorized shares of capital stock of, or other equity interests in, CBH subject
to) any  preemptive or similar  rights  created by statute,  the  certificate of
incorporation  or by-laws of CBH or any  agreement to which CBH is a party or by
which it may be bound.


                                      -16-


            3.19.2 The authorized  capital stock of Erye consists  solely of 51%
ownership  interest  owned by CBH and 49% ownership  interest held by EET. There
are not any existing options, warrants, calls, subscriptions, or other rights or
other agreements or commitments  obligating Erye to issue,  transfer or sell any
equity of Erye or any other securities  convertible into or evidencing the right
to subscribe for any such shares.  There are no outstanding  stock  appreciation
rights with respect to the capital of Erye. All issued and outstanding equity of
Erye is duly authorized and validly  issued,  fully paid and  nonassessable  and
have not been issued in  violation of (nor are any of the  authorized  shares of
capital stock of, or other equity  interests in, Erye subject to) any preemptive
or similar  rights  created by statute,  the  certificate  of  incorporation  or
by-laws of Erye or any  agreement to which Erye is a party or by which it may be
bound.

            3.19.3 Except as set forth in Section  3.19.3 of the CBH  Disclosure
Statement, there are no (i) obligations,  contingent or otherwise, of CBH or its
Subsidiaries to repurchase, redeem or otherwise acquire any shares of CBH Common
Stock,  CBH Preferred  Stock or any  securities of Erye, or provide funds to, or
make  any  investment  in (in  the  form  of a  loan,  capital  contribution  or
otherwise),  or provide any guarantee  with respect to the  obligations  of, any
other person,  or (ii) agreements,  arrangements or commitments of any character
(contingent or otherwise)  pursuant to which any person is or may be entitled to
receive  any  payment  based  on the  revenues  or  earnings  (or any  component
thereof),  or  calculated  in  accordance  therewith,  of  CBH  or  any  of  its
Subsidiaries.  Section  3.19.3 of the CBH  Disclosure  Statement  sets forth the
contingent  earn-out  obligations  to which  CBH or any of its  Subsidiaries  is
subject.   There  are  no  voting  trusts,   proxies  or  other   agreements  or
understandings  to which CBH or its  Subsidiaries  is a party or by which CBH or
its  Subsidiaries  is bound with  respect to the voting of any shares of capital
stock of CBH.

            3.19.4 CBH has delivered or made  available to NeoStem  complete and
correct copies of each of the CBH Warrants. Section 3.19.4 of the CBH Disclosure
Statement sets forth a complete and correct list of all restricted  stock awards
applicable  to CBH Common  Stock,  including  the  recipients  and the number of
shares of CBH Common Stock received or to be received by each.

            3.20  Capital  Stock of  Subsidiaries.  The only  direct or indirect
Subsidiaries  of CBH are those  listed  in  Section  3.20 of the CBH  Disclosure
Statement.  Except as set forth in Section 3.20 of the CBH Disclosure Statement,
CBH is directly or indirectly the record and beneficial  owner of (i) 90% of the
outstanding  shares of capital stock of Nanjing  Keyuan,  51% of the outstanding
equity interest of Erye and 100% of the  outstanding  shares of capital stock of
CBC and each of CBH's other  Subsidiaries.  There are no proxies with respect to
such  shares,  and  there  are  not  any  existing  options,   warrants,  calls,
subscriptions, or other rights or other agreements or commitments obligating CBH
or any of such  Subsidiaries  to issue,  transfer  or sell any shares of capital
stock of any of such  Subsidiaries or any other  securities  convertible into or
evidencing  the right to subscribe  for any such shares.  Each of the holders of
capital  stock  of the  Subsidiaries  which  is not  wholly-owned,  directly  or
indirectly,  by CBH is set  forth  on  Schedule  3.20.  All of  such  shares  so
beneficially  owned by CBH are duly authorized and validly  issued,  fully paid,
nonassessable  and free of preemptive  rights with respect thereto and are owned
by CBH, directly or indirectly, free and clear of any claim, lien or encumbrance
of any kind with respect thereto. Except as set forth in Section 3.20 of the CBH
Disclosure  Statement,  CBH does not directly or indirectly  own any interest in
any corporation,  partnership, limited liability company, joint venture or other
business association or entity.


                                      -17-


      3.21 Litigation. Except as set forth in Section 3.21 of the CBH Disclosure
Statement or in the CBH SEC Reports, as of the date hereof there are no material
pending actions, suits, proceedings, arbitrations or, to the knowledge of CBH or
Erye,  investigations  by, against or affecting CBH, any of its  Subsidiaries or
any of their  officers,  directors,  properties,  assets or operations,  or with
respect  to  which  CBH  or any of its  Subsidiaries  is  responsible  by way of
indemnity  or  otherwise.  Except  as set  forth  in  Section  3.21  of the  CBH
Disclosure  Statement or the CBH SEC Reports:  (i) there are no material pending
or, to the knowledge of CBH or Erye,  threatened  actions,  suits,  proceedings,
arbitrations  or  investigations  by,  against  or  affecting  CBH,  any  of its
Subsidiaries  or  any  of  their  officers,  directors,  properties,  assets  or
operations, or with respect to which they are responsible by way of indemnity or
otherwise,  whether or not  disclosed in such CBH SEC  Reports;  and (ii) to the
knowledge of CBH or Erye,  there are no material  actions,  suits,  proceedings,
arbitrations or  investigations  are threatened or contemplated  and there is no
reasonable  basis,  to  the  knowledge  of  CBH,  for  any  such  action,  suit,
proceedings,  arbitrations  or  investigation,  whether  or  not  threatened  or
contemplated.

      3.22  Insurance.  CBH and Erye have insurance  policies and fidelity bonds
covering  it and its  Subsidiaries'  assets,  business,  equipment,  properties,
operations,  employees, officers and directors which CBH and Eyre reasonably and
in good faith  believes  are  adequate  to conduct  the  business of CBH and its
Subsidiaries.  All  premiums due and payable  under all such  policies and bonds
have been  paid,  and CBH is  otherwise  in full  compliance  with the terms and
conditions of all such policies and bonds, except where the failure to have made
payment or to be in full compliance would not,  individually or in the aggregate
with all such other failures, have a CBH Material Adverse Effect. CBH reasonably
believes that the reserves established by CBH and Erye in respect of all matters
as to which CBH or any of its  Subsidiaries  self-insures  or carries  retention
and/or  deductibles,  including without limitation workers' medical coverage and
workers' compensation, are adequate and appropriate, and neither CBH nor Eyre is
aware of any facts or  circumstances  existing  as of the date hereof that would
reasonably  be expected to cause such  reserves to be  materially  inadequate or
inappropriate.

            3.23 Title to and  Condition of  Properties.  Except as set forth in
Section 3.23 of the CBH Disclosure Statement, CBH and its Subsidiaries have good
title to all of the real property and personal property  reflected on CBH's June
30, 2008  unaudited  consolidated  balance  sheet  contained in CBH's  Quarterly
Report on Form  10-QSB for the  quarter  ended June 30,  2008 filed with the SEC
(the "CBH Balance Sheet"),  except for property since sold or otherwise disposed
of in the ordinary  course of business  and  consistent  with past  practice and
except for defects of title which are not  material to CBH and its  Subsidiaries
taken as a whole.  Except as set  forth in  Section  3.23 of the CBH  Disclosure
Statement,  neither CBH nor any of its Subsidiaries  owns any real property.  No
real or personal  property owned or leased by CBH or any of its  Subsidiaries is
subject  to  claims,  liens or  other  encumbrances  of any  kind or  character,
including,  without  limitation,  mortgages,  pledges,  liens,  conditional sale
agreements,  charges,  security  interests,  easements,  restrictive  covenants,
rights of way or options,  except for (i) liens for taxes not yet  delinquent or
which  are being  contested  in good  faith by  appropriate  proceedings  and in
respect of which CBH or its  appropriate  Subsidiary  has set aside on its books
adequate reserves in accordance with generally accepted  accounting  principles;
(ii) mechanics', carriers', workers', repairers', materialmen's,  landlords' and
other similar  statutory or common law liens incurred in the ordinary  course of
business for  obligations  not yet  delinquent or the validity of which is being
contested in good faith by appropriate  proceedings  and in respect of which CBH
or its  appropriate  Subsidiary has set aside on its books adequate  reserves in
accordance with generally accepted accounting  principles;  (iii) in the case of
real  property,  easements,  rights  of  way,  restrictions,  minor  defects  or
irregularities  in title that do not  individually  or in the  aggregate  have a
material  adverse  effect  on the value or use of the real  property  encumbered
thereby  as  currently  used  in the  operation  of the  business  of CBH or its
Subsidiaries;  (iv) those which would not materially  interfere with the conduct
of the  business of CBH and its  Subsidiaries  (the  encumbrances  described  in
clauses (i) through  (iv) of this  sentence,  collectively,  the "CBH  Permitted
Encumbrances");  (v) those  securing  liabilities  reflected  in the CBH Balance
Sheet; or (vi) those described in Section 3.23 of the CBH Disclosure Statement.


                                      -18-


      3.24 Leases.  There have been  delivered or made available to NeoStem true
and complete  copies of each lease  pursuant to which Real  Property or personal
property  is held under lease by CBH or Erye  (limited,  in the case of personal
property,  to leases pursuant to which annual rentals are reasonably expected to
be at least  $100,000  per  year),  and true and  complete  copies of each lease
pursuant  to which  CBH or Erye  leases  real or  personal  property  to  others
(limited in the case of personal  property,  to leases  pursuant to which annual
rentals are reasonably expected to be at least $100,000 per year).  Section 3.24
of the CBH Disclosure  Statement sets forth a true and complete list of all such
leases,  and such leases are the only leases that are  material to the  business
conducted by CBH or Erye taken as a whole.  All of the leases so listed (i) are,
in all material respects, valid and subsisting and in full force and effect with
respect  to CBH or Erye,  as the  case may be,  and,  to CBH's  knowledge,  with
respect to any other  party  thereto and (ii) were  entered  into as a result of
bona fide arm's length negotiations with the other party or parties thereto. CBH
or Erye have valid leasehold  interests in all properties leased thereunder free
and  clear of all  material  liens and  encumbrances  other  than CBH  Permitted
Encumbrances.  The real  properties  leased by CBH or Erye are, in all  material
respects,  in good operating  order and condition,  subject to ordinary wear and
tear.  To the  knowledge  of CBH and  Erye,  there are no  material  structural,
mechanical or other defects in any improvements located on such real properties.

            3.25 Contracts and Commitments.  Except as set forth in Section 3.25
of the CBH  Disclosure  Statement  or as set  forth as an  exhibit  in a CBH SEC
Report filed since December 31, 2007, neither CBH nor any of its Subsidiaries is
a party to any existing  contract,  obligation  or  commitment of any type which
requires  payment  by or to any party  thereto  in excess of  $50,000.  True and
complete copies of all contracts,  obligations and commitments listed in Section
3.25  of the  CBH  Disclosure  Statement  (translated  into  English  where  the
originals are in Chinese) have been delivered or made available to NeoStem. None
of CBH or Erye or, to the knowledge of CBH or Erye, any other party is in breach
of or default under any of the contracts,  obligations and commitments listed in
Section 3.25 of the CBH  Disclosure  Statement or under any other CBH  Contracts
(and,  to the  knowledge  of CBH,  no facts or  circumstances  exist which could
reasonably  support the  assertion  of any such  breach or  default)  except for
breaches and defaults which would not, singly or in the aggregate with all other
such  breaches,  have a CBH  Material  Adverse  Effect.  For  purposes  of  this
Agreement, an "Affiliate" of a Person means a Person that directly or indirectly
through one or more  intermediaries,  controls,  is  controlled  by, or is under
common control with, the first Person, including but not limited to a subsidiary
of the first  Person,  a Person of which the first  Person is a  subsidiary,  or
another  Subsidiary  of a Person of which the first Person is also a subsidiary;
and "Control"  (including  the terms  "controlled  by" and "under common control
with") means the possession,  directly or indirectly,  of the power to direct or
cause the direction of the management policies of a Person,  whether through the
ownership of voting securities, by contract or credit arrangement, as trustee or
executor, or otherwise.


                                      -19-


      3.26 Employees;  Labor Matters. Except as set forth in Section 3.26 of the
CBH  Disclosure  Statement,  neither  CBH nor Erye is a party to or bound by any
collective  bargaining  agreement,  and  there  are no  labor  unions  or  other
organizations  representing,  purporting to represent or attempting to represent
any employees employed by CBH or Erye thereof.  Since January 1, 2004, there has
not occurred or been threatened any material strike, slowdown,  picketing,  work
stoppage,  concerted  refusal to work overtime or other  similar labor  activity
with  respect to any  employees of CBH or Erye  thereof.  Except as set forth in
Section  3.26 of the CBH  Disclosure  Statement,  there  are no  labor  disputes
currently  subject to any grievance  procedure,  arbitration  or litigation  and
there is no  representation  petition  pending or threatened with respect to any
employee of CBH or any  Subsidiary  thereof.  Each of CBH and Erye has  complied
with all applicable laws,  statutes,  orders,  rules,  regulations,  policies or
guidelines  promulgated,  or  judgments,  decisions  or orders  entered,  by any
Governmental  Authority (as defined  herein) (all such laws,  statutes,  orders,
rules,  regulations,  policies,  guidelines,  judgments,  decisions  and orders,
collectively,  "Applicable Laws") pertaining to the employment or termination of
employment of their respective  employees,  including,  without limitation,  all
such   Applicable   Laws   relating  to  labor   relations,   equal   employment
opportunities,   fair  employment   practices,   prohibited   discrimination  or
distinction and other similar employment  activities.  Contributions required to
be made by  employers  under the  Applicable  Laws to all the  mandatory  social
welfare and pension funds in respect of all  employees of CBH or any  Subsidiary
thereof have been duly and punctually paid in full.

      3.27 No Change of Control Puts. Except as described in Section 3.27 of the
CBH  Disclosure  Statement,  neither the  execution  and delivery by CBH of this
Agreement  nor  the  consummation  of  the  Merger  or  any  other   transaction
contemplated  hereby  gives  rise  to  any  obligation  of  CBH  or  any  of its
Subsidiaries to, or any right of any holder of any security of CBH or any of its
Subsidiaries to require CBH or any of its Subsidiaries  to,  purchase,  offer to
purchase,  redeem or otherwise prepay or repay any such security, or deposit any
funds to effect the same.

      3.28 Employment and Labor  Contracts.  Except as set forth in Section 3.28
of the  CBH  Disclosure  Statement,  neither  CBH nor  Erye  is a  party  to any
employment,  management  services,  consultation  or other contract or agreement
that  provides  for annual  compensation  of  $50,000 or more,  with any past or
present  officer,  director or employee or, to the  knowledge of CBH, any entity
affiliated with any past or present  officer,  director or employee,  other than
the  agreements  executed by employees  generally,  the forms of which have been
provided to NeoStem.


                                      -20-


      3.29 Intellectual  Property Rights.  CBH and Erye own or have the right to
use all material CBH Intellectual  Property Rights (as defined herein) necessary
to the  conduct  of  their  respective  businesses.  Subject  to  obtaining  any
associated  consents with respect to  agreements  or licenses  listed in Section
3.3.2 of the CBH  Disclosure  Statement,  each CBH  Intellectual  Property Right
owned or used by CBH or Erye  immediately  prior to the  Effective  Time will be
owned or available for use, in all material  respects,  by the Surviving Company
or its subsidiaries on substantially  the same terms and conditions  immediately
subsequent to the Effective Time.  Section 3.29 of the CBH Disclosure  Statement
contains a list of all material  patents,  trade names,  registered  copyrights,
trademarks  and service  marks,  mask works and  applications  for the foregoing
owned or used by CBH and Erye.  Except as set forth in  Section  3.29 of the CBH
Disclosure  Statement,  (i) CBH or Erye have valid and unencumbered  (except for
CBH Permitted  Encumbrances)  title to the CBH Intellectual  Property Rights set
forth in such Section 3.29 and, to the knowledge of CBH or Erye,  such title has
not  been   challenged   (pending  or  threatened)  by  others  except  for  the
encumbrances  listed  therein;  (ii) no  material  rights or licenses to use CBH
Intellectual Property Rights have been granted or acquired by CBH or Erye; (iii)
there  have been no claims or  assertions  made by others  that CBH and Erye has
infringed any Intellectual  Property Rights (as defined herein) of others by the
sale of products, the rendering of services or any other activity since December
31, 2002;  (iv) to the knowledge of CBH, there has been no such  infringement by
CBH or any of its Subsidiaries since December 31, 2002; (v) CBH and Erye have no
knowledge of any infringement of CBH Intellectual  Property Rights of CBH or any
of its  Subsidiaries by others;  and (vi) all CBH  Intellectual  Property Rights
owned by CBH or Erye (a) are in good  standing with the  registration  authority
therefor,  if any, (b) to the extent recorded on the public record, are recorded
in the name of CBH or Erye and (c) have been duly registered  with,  filed in or
issued by, as the case may be,  the State  Intellectual  Property  Office of the
PRC, the National  Copyright  Administration  of the PRC and Trademark Office of
Stated  Administration  For Industry & Commerce in the PRC, and the U.S.  Patent
and Trademark  Office and the U.S.  Copyright  Office and other filing  offices,
domestic  or  foreign,  to the extent  necessary  or  desirable  to ensure  full
protection  under any  Applicable  Law,  and the same  remain in full  force and
effect.  True and complete  copies of all material listed in Section 3.29 of the
CBH Disclosure  Statement have been delivered or made available to NeoStem.  For
purposes of this Agreement,  the phrase  "Intellectual  Property Rights",  shall
mean and include,  with respect to any Person, rights of such Person relating to
patents, trademarks, service marks, collective marks, certification marks, trade
names, copyrights,  mask works, inventions,  processes, trade secrets, know-how,
confidentiality   agreements,    consulting   agreements,   software   and   any
documentation  relating  to  the  manufacture,  marketing,  sale,  licensing  or
maintenance  of  products  or  services  by such  Person;  and the  phrase  "CBH
Intellectual  Property  Rights" shall mean the  Intellectual  Property Rights of
each of CBH and Erye, excluding any Intellectual  Property Rights held solely by
CBC or Nanjing Keyuan.


                                      -21-


      3.30 Taxes.

            3.30.1  Except as set forth in  Section  3.30 in the CBH  Disclosure
Statement,  (i) all Returns (as defined herein) required to be filed by, or with
respect to any  activities or assets of, each of CBH and its  Subsidiaries  have
been  duly and  timely  filed  and are  correct  and  complete  in all  material
respects, (ii) all Taxes (as defined herein) shown as owing on such Returns have
been paid and (iii) none of CBH or its Subsidiaries is currently the beneficiary
of any extension of time within which to file any Return.

            3.30.2  Except as set forth in  Section  3.30 of the CBH  Disclosure
Statement,  (i) all Taxes  that are or may  become  payable by any of CBH or its
Subsidiaries or chargeable as an Encumbrance (as defined herein) upon its assets
for which the filing of a Return is not required  have been duly and timely paid
and (ii) each of CBH and its Subsidiaries has duly and timely withheld all Taxes
required  to be  withheld  in  connection  with the  business  or assets of such
entity,  and such  withheld  Taxes have been  either duly and timely paid to the
proper  governmental  authorities  or properly  set aside in  accounts  for such
purpose.

            3.30.3  Except as set forth in  Section  3.30 of the CBH  Disclosure
Statement,  there has been no claim or issue  (other  than a claim or issue that
has been  finally  settled)  concerning  any  liability  for Taxes of CBH or any
Subsidiary  thereof asserted,  raised or threatened by any taxing authority and,
to the knowledge of CBH and its Subsidiaries, no circumstances exist to form the
basis for such a claim or issue.

            3.30.4 Section 3.30 of the CBH Disclosure Statement lists all Income
Tax Returns (as defined herein) that have been filed with respect to each of CBH
and its  Subsidiaries  for taxable periods ended on or after January 1, 2006 and
that have not yet been audited or are currently the subject of audit.

            3.30.5  Except as set forth in  Section  3.30 of the CBH  Disclosure
Statement,  none  of CBH or its  Subsidiaries  has (i)  waived  any  statute  of
limitations,  (ii)  agreed to any  extension  of the  period for  assessment  or
collection  or (iii)  executed  or filed any power of attorney  with  respect to
Taxes, which waiver, agreement or power of attorney is currently in force.

            3.30.6  Except as set forth in  Section  3.30 of the CBH  Disclosure
Statement,  (i) there are no outstanding  adjustments for Income Tax (as defined
herein)  purposes  applicable  to CBH or any of its  Subsidiaries  required as a
result of changes in methods  of  accounting  effected  on or before the date of
this Agreement and (ii) no material  elections for Income Tax purposes have been
made by any of CBH or its  Subsidiaries  that are currently in force or by which
any of CBH or its Subsidiaries is bound.

            3.30.7  Except as set forth in  Section  3.30 of the CBH  Disclosure
Statement,  none of CBH or its Subsidiaries (i) is a party to or bound by or has
any obligation under any Tax allocation, sharing, indemnity or similar agreement
or arrangement or (ii) is or has been a member of any group of companies  filing
a consolidated, combined or unitary Income Tax Return.


                                      -22-


            3.30.8 For purposes of this  Agreement,  the  following  terms shall
have the meanings ascribed to them below:

                  (i) "Encumbrance"  means any mortgage,  pledge, deed of trust,
hypothecation,  right of others, claim, security interest, encumbrance,  burden,
title defect, title retention agreement,  lease,  sublease,  license,  occupancy
agreement, easement, covenant, condition,  encroachment, voting trust agreement,
interest,  option,  right of first offer,  negotiation or refusal,  proxy, lien,
charge or other restriction or limitations of any nature  whatsoever,  including
but not limited to such Encumbrances as may arise under any contract.

                  (ii)  "Income  Tax" means any Tax computed in whole or in part
based on or by reference to net income and any alternative, minimum, accumulated
earnings or personal  holding  company Tax (including all interest and penalties
thereon and additions thereto).

                  (iii)   "Income   Tax  Return"   means  any  return,   report,
declaration,  form, claim for refund or information return or statement relating
to Income Taxes, including any schedule or attachment thereto, and including any
amendment thereof.

                  (iv) "Return"  means any return,  report,  declaration,  form,
claim for refund or information return or statement relating to Taxes, including
any schedule or attachment thereto, and including any amendment thereof.

                  (v) "Tax" means any federal,  state,  local or foreign income,
alternative, minimum, accumulated earnings, personal holding company, franchise,
capital stock,  profits,  windfall  profits,  gross receipts,  sales, use, value
added,  transfer,   registration,   stamp,  premium,   excise,  customs  duties,
severance,   environmental,   real  property,  personal  property,  ad  valorem,
occupancy,   license,   occupation,   employment,   payroll,   social  security,
disability, unemployment, workers' compensation, withholding, estimated or other
similar tax, duty, fee,  assessment or other governmental charge or deficiencies
thereof (including all interest and penalties thereon and additions thereto).

      3.31 Employee Benefit Plans

            3.31.1  Except as set forth in  Section  3.31 of the CBH  Disclosure
Statement,  with  respect  to any  employee  or  former  employee  of CBH or any
Subsidiary  thereof,  none of CBH or Erye, or any Affiliated  company  presently
maintains,  contributes to or has any liability under: (i) any bonus,  incentive
compensation,  profit  sharing,  retirement,  pension,  group  insurance,  death
benefit, cafeteria, medical expense reimbursement, dependent care, stock option,
stock purchase,  stock appreciation rights,  deferred compensation,  consulting,
severance  pay or  termination  pay,  vacation  pay,  welfare or other  employee
benefit  or fringe  benefit  plan,  program  or  arrangement;  or (ii) any plan,
program  or  arrangement  which  is an  employee  pension  benefit  plan,  or an
"employee welfare benefit plan" as defined under relevant laws applicable to CBH
or any  Subsidiary  thereof.  Each plan,  program and  arrangement  set forth in
Section 3.31 of the CBH  Disclosure  Statement  is herein  referred to as a "CBH
Employee  Benefit Plan." The term  "affiliated  company" means any  organization
that would be aggregated with any of CBH or any Subsidiary thereof under Section
414(b), (c), (m) or (o) of the Code.


                                      -23-


            3.31.2  There is no  pending  or  threatened  legal  action,  claim,
proceeding or  investigation  against or involving any CBH Employee Benefit Plan
(other than  routine  claims for  benefits)  and there is no basis for any facts
which could give rise to any such condition,  legal action, claim, proceeding or
investigation.

            3.31.3 None of CBH or Erye nor any of their affiliates is a party to
any employment  agreement,  whether written or oral, or agreement with change in
control or similar provisions,  or a collective bargaining agreement or contract
with any labor union relating to any employees or former employees of CBH or any
Subsidiary thereof.

      3.32 Environmental Matters.

            3.32.1  Each of CBH  and its  Subsidiaries  has  complied  and is in
compliance in all material respects with all applicable  Environmental  Laws (as
defined  herein)  pertaining to any of the  properties and assets of CBH and its
Subsidiaries   (including  all  real  property  owned  by  CBH  or  any  of  its
Subsidiaries, together with all structures, facilities,  improvements, fixtures,
systems,  equipment and items of property presently or hereafter located thereon
or attached or  appurtenant  thereto or owned by CBH or any of its  Subsidiaries
and located on real property leased by CBH or any of its  Subsidiaries,  and all
easements,   licenses,  rights  and  appurtenances  relating  to  the  foregoing
(collectively,  the "CBH Real Property") and the use and ownership thereof,  and
to the operation of their respective businesses. No material violation by CBH or
any of its  Subsidiaries  is being alleged of any applicable  Environmental  Law
relating to any of the properties  and assets of CBH or any of its  Subsidiaries
(including  the CBH Real  Property) or the use or ownership  thereof,  or to the
operation of their respective businesses.

            3.32.2  None  of  CBH  or  its  Subsidiaries  or  any  other  Person
(including  any tenant or  subtenant)  has caused or taken any action  that will
result  in,  nor is CBH or any  Subsidiary  thereof  subject  to,  any  material
liability or obligation on the part of CBH or any  Subsidiary  thereof or any of
its Affiliates, relating to (x) the environmental conditions on, under, or about
the CBH Real Property or other properties or assets owned,  leased,  operated or
used by CBH or any of its Subsidiaries or any predecessor thereto at the present
time or in the past, including without limitation, the air, soil and groundwater
conditions  at such  properties  or (y) the  past or  present  use,  management,
handling,  transport,  treatment,  generation,  storage, disposal or Release (as
defined herein) of any Hazardous (as defined herein) materials.

                  3.32.2.1 CBH has disclosed  and made  available to NeoStem all
information,  including,  without  limitation,  all  studies,  analyses and test
results,  in the possession,  custody or control of or otherwise known to CBH or
its Subsidiaries relating to (x) the environmental conditions on, under or about
the Real Property or other properties or assets owned, leased,  operated or used
by CBH or any of its  Subsidiaries  any  predecessor in interest  thereto at the
present time or in the past,  and (y) any  Hazardous  materials  used,  managed,
handled,  transported,  treated,  generated, stored or Released by CBH or any of
its  Subsidiaries  or any other Person on,  under,  about or from any of the CBH
Real  Property,  or otherwise in connection  with the use or operation of any of
the properties and assets of CBH or any of its  Subsidiaries or their respective
businesses.


                                      -24-


            3.32.3 For purposes of this  Agreement,  the  following  terms shall
have the meanings ascribed to them below:

                  3.32.3.1  "Environmental  Laws" means all Laws relating to the
protection  of  the  environment,   to  human  health  and  safety,  or  to  any
Environmental activity,  including, without limitation, (a) CERCLA, the Resource
Conservation  and Recovery Act, and the  Occupational  Safety and Health Act, or
any  equivalent  law  under  the  PRC,  including,   without   limitation,   the
Environmental  Protection  Law of the PRC, the Law of the PRC on  Appraising  of
Environmental  Impacts  and the  Law of the PRC on  Prevention  and  Control  of
Environmental Pollution by Solid Waste, (b) all other requirements pertaining to
reporting,  licensing,  permitting,  investigation  or remediation of emissions,
discharges, releases or threatened releases of Hazardous materials into the air,
surface water, groundwater or land, or relating to the manufacture,  processing,
distribution,  use, sale, treatment,  receipt, storage,  disposal,  transport or
handling of Hazardous materials and (c) all other requirements pertaining to the
protection of the health and safety of employees or the public.

                  3.32.3.2  "Hazardous  Materials" means any substance that: (a)
is or contains  asbestos,  urea  formaldehyde  foam insulation,  polychlorinated
biphenyls,  petroleum or  petroleum-derived  substances  or wastes,  radon as or
related materials (b) requires  investigation,  removal or remediation under any
Environmental Law, or is defined, listed or identified as a "hazardous waste" or
"hazardous  substance"  thereunder,  or  (c)  is  toxic,  explosive,  corrosive,
flammable,  infectious,  radioactive,   carcinogenic,  mutagenic,  or  otherwise
hazardous and is regulated by any Governmental Authority or Environmental Law.

                  3.32.3.3    "Release"   means   any   releasing,    disposing,
discharging, injecting, spilling, leaking, leaching, pumping, dumping, emitting,
escaping,  emptying,  seeing,  dispersal,  leeching,  migration,   transporting,
placing and the like, including without limitation,  the moving of any materials
through,  into or upon, any land, soil,  surface water,  ground water or air, or
otherwise entering into the environment.

      3.33 CBH Business Matters.

            3.33.1 None of CBH,  Erye or any  director,  agent,  employee or any
other person acting for or on behalf of CBH or Erye,  has directly or indirectly
made  any  unlawful  contribution,   gift,  bribe,  payoff,  influence  payment,
kickback,  or any  other  fraudulent  payment  in any  form,  whether  in money,
property,  or  services to any  person,  including  but not limited to any staff
member at any hospital or center for disease  control or any government  officer
(a) to obtain favorable  treatment in securing  business for CBH or Erye, (b) to
pay  for  favorable  treatment  for  business  secured,  (c) to  obtain  special
concessions or for special  concessions  already obtained,  for or in respect of
CBH or Erye, or (d) in violation of any applicable anti-corruption law.

            3.33.2 None of CBH,  Erye or any  director,  agent,  employee or any
other  person  acting  for or on  behalf  of CBH or  Erye,  has  established  or
maintained any fund or assets in which such Group Company has proprietary rights
that  have not been  recorded  in the  books and  records  of CBH or Erye.  Each
transaction is properly and accurately  recorded in all material respects on the
books and records of CBH or Erye,  and each  document  upon which  entries  such
books and records are based is complete and  accurate in all material  respects.
Each  of CBH and  Erye  maintains  a  system  of  internal  accounting  controls
reasonably  designed  to  insure  that  there is no  maintain  no  off-the-books
accounts  and  its  assets  are  used  only in  accordance  with  its  corporate
management directives.


                                      -25-


            3.33.3 Section 3.33.3 of the CBH Disclosure Agreement sets forth all
the land,  buildings  and  premises  currently  owned by Erye (the  "Owned  Real
Property").  The  description of the Owned Real Property as set forth in Section
3.33.3 of the CBH Disclosure Statement is true and complete.

            3.33.4 Erye has exclusive and unfettered possession,  occupation and
proper  legal  title to the land use rights  and  building  ownership  rights in
respect of the Owned Real Property (including  possession of the land use rights
certificates  and  building   ownerships   certificates)  and  are,  subject  to
compliance with applicable laws of the PRC, entitled to transfer, sell, mortgage
or  otherwise  dispose of the Owned  Real  Property  and there are no  occupancy
rights or liens in favour of third parties affecting it.

            3.33.5 The original  land grant fee for the land use rights was paid
in full, and no further amounts are currently owed in respect thereof.  No other
fees or other payments are owed in respect of the Owned Real Property  including
in respect of the relocation of Erye to the site previously disclosed to NeoStem
by CBH. The  relevant  granted land use right  contracts  and the relevant  land
registration  cards  contain  no  restrictions  on Erye's  use of the Owned Real
Property for which such land use rights have been granted.

            3.33.6 There are no claims pending or, to CBH and Erye's  knowledge,
threatened  that  would  result in the  creation  of any lien on any Owned  Real
Property.

            3.33.7 There are no zoning or other  applicable  laws or regulations
currently  in effect  that  would  prevent  or limit  Erye from  conducting  its
operations  on the  Owned  Real  Property  as they are  currently  conducted  or
contemplated to be conducted.

            3.33.8 There are not material  assets or properties  shared with any
other entity,  which are used in connection with the business conducted by Erye,
and all of the  facilities,  services,  assets or  properties  owned by Erye are
sufficient to conduct its business as proposed to be conducted.

With respect to the  relocation of Erye's  workshop,  Erye has all approvals and
certificates  necessary for the title to and legal use of the building  which is
under  construction  on the  date of this  Agreement.  CBH  intends  for Erye to
relocate  its workshop to the  completed  building,  which shall ensure  optimum
operation  and  production  of  Erye,  on  or  about  December  31,  2011.

      3.34 Disclosure.  All information  disclosed by or on behalf of CBH or its
Subsidiaries  to NeoStem or its  advisers on or prior to the date hereof is true
and accurate in all material aspects, and CBH and its Subsidiaries are not aware
of any other  fact or  matter  which  renders  any such  information  misleading
because of any  omission,  ambiguity or for any other  reason.  All  information
contained  in the CBH  Disclosure  Statement is true and accurate in all aspects
and fairly presented and there is no fact or matter which has not been disclosed
in the CBH Disclosure  Statement  which renders any such  information  untrue or
misleading  and there is no fact or matter  concerning  CBH or its  Subsidiaries
which has not on the basis of the utmost  good faith been  disclosed  in the CBH
Disclosure  Statement  which  would  reasonably  be expected  to  influence  the
decision  of  NeoStem to  proceed  with the  Merger on the terms and  conditions
thereof.


                                      -26-


                                  ARTICLE IV.

               REPRESENTATION AND WARRANTIES OF NEOSTEM AND SUBCO

            Except as set forth in the disclosure statement delivered by NeoStem
to CBH at or prior to the execution of this Agreement  (the "NeoStem  Disclosure
Statement")  (each  section  of which  qualifies  the  correspondingly  numbered
representation  and  warranty,  regardless  of whether  such  representation  or
warranty  expressly  refers to or is  qualified  by  reference  to such  NeoStem
Disclosure  Statement)  or as disclosed in the NeoStem SEC Reports,  NeoStem and
Subco, jointly and severally,  represent and warrant to CBH as follows (it being
understood and agreed that each  representation and warranty with respect to any
payment  obligation  of NeoStem that is qualified  hereunder as to  materiality,
shall  refer to any such  obligation  (i)  having  a dollar  value of more  than
$50,000, to the extent such value is quantifiable, and (ii) not made or incurred
in the ordinary course of business):

      4.1 Organization and Qualification.

            4.1.1 Each of NeoStem  and its  Subsidiaries  (as defined in Section
4.1.2) is an entity duly  incorporated,  validly  existing and in good  standing
under the laws of the  jurisdiction of its  incorporation  and has the corporate
power and authority to own,  lease and operate its properties and to conduct its
business as  described in the NeoStem SEC Reports (as defined  herein).  Each of
NeoStem  and  each of  NeoStem's  Subsidiaries  is duly  qualified  to  transact
business  as a  foreign  corporation  or  other  foreign  entity  and is in good
standing  in each  jurisdiction  in which the  conduct  of its  business  or the
ownership,  leasing or operation of its property  requires  such  qualification,
except for  failures to be so  qualified  or in good  standing  which would not,
singly or in the aggregate with all such other failures, have a NeoStem Material
Adverse Effect.  "NeoStem  Material  Adverse Effect" means,  with respect to any
event, occurrence, matter, failure of event or occurrence, change, effect, state
of  affairs,  breach,  default,  violation,  fine,  penalty or failure to comply
(each,  a  "Circumstance"),  individually  or  taken  together  with  all  other
Circumstances  contemplated  by  or  in  connection  with  any  or  all  of  the
representations and warranties made in this Agreement, a material adverse effect
on the  business,  assets  (including  without  limitation  intangible  assets),
liabilities   (contingent  or  otherwise),   financial  condition,   results  of
operations  or  prospects  of NeoStem  and its  Subsidiaries,  taken as a whole;
provided,  however,  that NeoStem Material Adverse Effect shall not be deemed to
include  the  impact  of: (A) the  implementation  of changes in U.S.  generally
accepted  accounting  principles;  (B) actions and  omissions  of NeoStem or its
Subsidiaries  taken or permitted with the prior written consent of CBH after the
date hereof; (C) expenses  reasonably incurred by NeoStem or its Subsidiaries in
consummating the transactions contemplated by this Agreement; (D) changes in the
general economic or financial market conditions; (E) any occurrence,  condition,
change,  event or effect that affects the stem cell industry generally;  and (F)
the  outbreak  or  escalation  of  hostilities  involving  the PRC or the United
States, the declaration by the PRC or the United States of war or the occurrence
of any natural disasters and acts of terrorism.


                                      -27-


            4.1.2 Neither NeoStem nor any of its Subsidiaries is in violation of
any of the provisions of its certificate of incorporation  or by-laws,  or other
similar organizational  documents,  each as amended and currently in effect, or,
if it is a limited  liability company or partnership,  its operating  agreement,
partnership agreement or other comparable agreement. True and complete copies of
the certificate of incorporation  and by-laws,  each as amended and as currently
in  effect,  of  NeoStem  and true and  complete  copies of the  certificate  of
incorporation and by-laws, or other similar  organizational  documents,  each as
amended  and  currently  in effect,  of each  Subsidiary  of  NeoStem  have been
previously  delivered or made  available to CBH.  Except for an amendment to the
certificate  of  incorporation  to  increase  the  number of  shares of  NeoStem
Preferred  Stock  authorized  for issuance by NeoStem in order to consummate the
transactions  contemplated  by this  Agreement,  which may be  authorized by the
NeoStem Board of Directors,  subject to the approval of the NeoStem Stockholders
at  the  NeoStem   Annual   Meeting,   no  amendments  to  the   certificate  of
incorporation, as amended, of NeoStem have been authorized since August 8, 2007,
and no amendments to the by-laws of NeoStem have been authorized since August 1,
2006. For purposes of this Agreement,  all references to the  "Subsidiaries"  of
NeoStem  shall  constitute  references  to any entity (i) the  accounts of which
would be consolidated with those of NeoStem in NeoStem's  consolidated financial
statements  if such  financial  statements  were  prepared  in  accordance  with
generally  accepted  accounting  principles or (ii) of which securities or other
ownership interests representing more than 50% of the equity or more than 50% of
the ordinary voting power or, in the case of a partnership, more than 50% of the
general  partnership  interests  or more than 50% of the  profits  or losses are
owned by NeoStem and/or one or more subsidiaries of NeoStem.

      4.2 Authority  Relative to this  Agreement.  Each of NeoStem and Subco has
the  corporate  power and authority to execute and deliver this  Agreement  and,
upon obtaining the approval of a majority of the  outstanding  shares of NeoStem
Common  Stock at the  NeoStem  Annual  Meeting  or any  adjournment  thereof  as
authorized  under the DGCL, to consummate the Merger and the other  transactions
contemplated  hereby.  The  execution  and  delivery of this  Agreement  and the
consummation of the Merger and the other transactions  contemplated  hereby have
been duly and  validly  authorized  by the Boards of  Directors  of NeoStem  and
Subco,  and  except as  stated in the  preceding  sentence,  no other  corporate
proceedings  on the part of NeoStem or Subco are  necessary  to  authorize  this
Agreement or to consummate  the Merger and the other  transactions  contemplated
hereby.  This  Agreement  has been duly and validly  executed  and  delivered by
NeoStem and Subco and,  assuming the due  authorization,  execution and delivery
hereof by CBH and subject to  stockholder  approval as aforesaid,  constitutes a
valid and binding  agreement of each of NeoStem and Subco,  enforceable  against
NeoStem and Subco in  accordance  with its terms,  except to the extent that its
enforceability   may  be   limited   by   applicable   bankruptcy,   insolvency,
reorganization, moratorium or other laws affecting the enforcement of creditors'
rights generally or by general equitable principles.


                                      -28-


      4.3 Consents, No Conflicts.

            4.3.1  Except  for  actions to be taken in  connection  with (a) the
filing of the  Certificate  of Merger  (including  the increase in the preferred
stock),  (b) the filing and  effectiveness of the Registration  Statement and/or
Joint Proxy Statement and shareholder approval thereunder,  (c) filings required
pursuant to any state securities or "blue sky" laws, (d) filings,  approvals for
listing and other  matters  relating to the listing or quoting on an Exchange of
the  shares of NeoStem  Common  Stock  required  to be issued  pursuant  to this
Agreement, and (e) any other filings, notices,  disclosures or registrations set
forth in  Section  4.3.1 of the  NeoStem  Disclosure  Statement,  no  filing  or
registration  with,  notification  or disclosure  to, or permit,  authorization,
consent or approval  of, (x) any  Government  Authority  or (y) any third party,
whether acting in an individual,  fiduciary or other  capacity,  is required for
the  consummation  by NeoStem  or Subco of the Merger or the other  transactions
contemplated hereby.

            4.3.2 Except as set forth in Section 4.3.2 of the NeoStem Disclosure
Statement,  the  execution,  delivery and  performance of this Agreement and the
consummation of the Merger and the other  transactions  contemplated  hereby and
compliance  by NeoStem  and Subco with any of the  provisions  hereof do not and
will not: (i) subject to obtaining  the approval of the Merger by holders of the
NeoStem Common Stock and the NeoStem Preferred Stock, conflict with or result in
any breach or violation of any provision of the certificate of  incorporation or
by-laws, or other similar organizational  documents, each as amended, of NeoStem
or any of its  Subsidiaries  or (ii) result in (1) a breach or  violation  of, a
default under or an event triggering any payment,  obligation or acceleration of
any obligation pursuant to any NeoStem Employee Benefit Plan (as defined herein)
or any grant or award made under any of the foregoing, (2) a breach or violation
of, a default under or an event  triggering a right of termination of, a default
under, or the acceleration of any obligation or the creation of a lien,  pledge,
security  interest or other encumbrance on assets (with or without the giving of
notice  or the  lapse  of  time or  both)  pursuant  to any  provision  of,  any
agreement,  lease of real or personal property,  marketing agreement,  contract,
note,  mortgage,  indenture  or  other  obligation  of  NeoStem  or  any  of its
Subsidiaries   ("NeoStem   Contracts")   or,  subject  to  making  all  filings,
notifications  and  disclosures  and  receipt  of all  permits,  authorizations,
consents and  approvals  referred to in clauses "a" through "e" of Section 4.3.1
or in  Section  4.3.1  of the  NeoStem  Disclosure  Statement,  any  law,  rule,
ordinance or regulation or judgment,  decree, order or award to which NeoStem or
any of its  Subsidiaries  is subject  or any  governmental  or  non-governmental
authorization,  consent, approval,  registration,  franchise,  license or permit
under which NeoStem or any of its Subsidiaries  conducts any of its business, or
(3) any other change in the rights or  obligations of any party under any of the
NeoStem  Contracts,  except,  with  respect to this clause (ii),  for  breaches,
violations,  defaults,  triggering events, creations of liens, pledges, security
interests or other  encumbrances on assets,  or changes in rights or obligations
which would not, singly or in the aggregate with all other such matters,  have a
NeoStem Material Adverse Effect.

            5.3.3 As of the date of execution of this Agreement, NeoStem has not
received any  de-listing  notice from the  Exchange on which the NeoStem  Common
Stock is listed or quoted with respect to its Common Stock.

      4.4  Board  Recommendation.  The  Board  of  Directors  or an  appropriate
committee of the Board of Directors of NeoStem has, by a unanimous vote of those
directors in  attendance  at a meeting of such Board or  committee  duly held on
October 31, 2008 approved and adopted this  Agreement,  the Merger and the other
transactions  contemplated  hereby.  At such meeting,  the Board of Directors of
NeoStem or board  committee  determined that the terms of the Merger are fair to
the holders of NeoStem  Common  Stock and  recommended  that the holders of such
shares approve and adopt this Agreement, the Merger, the issuance of the NeoStem
Common Stock pursuant to this Agreement and the other transactions  contemplated
hereby (the "NeoStem Board Recommendation").


                                      -29-


      4.5  State   Anti-takeover   Statutes;   Stockholder   Protection   Rights
Agreements. Other than the CBH Lock-Up and Voting Agreement, the NeoStem Lock-Up
and Voting Agreement (as defined herein) and the Confidentiality  Agreements (as
defined  herein),  there are no contracts  between  NeoStem or Subco, on the one
hand, and any member of CBH's management or directors,  on the other hand, as of
the date hereof that relate in any way to CBH or the  transactions  contemplated
by this  Agreement.  Prior  to the  Board of  Directors  of CBH  approving  this
Agreement,  the  Merger  and the  other  transactions  contemplated  hereby  for
purposes of the applicable  provisions of the DGCL,  neither  NeoStem nor Subco,
alone or  together  with any  other  person,  was at any  time,  or  became,  an
"interested stockholder" thereunder or has taken any action that would cause the
restrictions on business combinations with interested  stockholders set forth in
Section 203 of the DGCL to be applicable to this Agreement,  the Merger,  or any
transactions  contemplated  by this  Agreement.  NeoStem  is not a party  to any
stockholder protection rights agreement or any agreement similar thereto.

      4.6  No  Existing  Violation,   Default,  Etc.  None  of  NeoStem  or  its
Subsidiaries is in violation of (A) any Applicable Law or (B) any order,  decree
or judgment of any Governmental  Authority having  jurisdiction  over NeoStem or
any of its  Subsidiaries.  No event of default or event that, but for the giving
of notice or the lapse of time or both,  would  constitute  an event of default,
exists  under any  material  NeoStem  Contract or any  material  lease,  permit,
license  or  other  agreement  or  instrument  to  which  NeoStem  or any of its
Subsidiaries  is a party or by which any of them is bound or to which any of the
properties,  assets or  operations  of  NeoStem  or any of its  Subsidiaries  is
subject.

      4.7 Licenses and Permits.  Each of NeoStem and its  Subsidiaries  has such
certificates,   permits,  licenses,  franchises,  consents,  approvals,  orders,
authorizations and clearances from appropriate  governmental agencies and bodies
("NeoStem  Licenses") as are necessary to own,  lease or operate its  properties
and to conduct its  business in the manner  described in the NeoStem SEC Reports
and as presently  conducted and all such NeoStem  Licenses are valid and in full
force and effect, other than any failure to have any such NeoStem License or any
failure of any such NeoStem  License to be valid and in full force and effect as
would  not,  singly or in the  aggregate  with all such other  failures,  have a
NeoStem Material  Adverse Effect.  NeoStem and its Subsidiaries do not currently
participate in any Medicaid  program.  Each of NeoStem and its  Subsidiaries  is
and, within the period of all applicable  statutes of  limitations,  has been in
compliance  with its  obligations  under such NeoStem  Licenses and no event has
occurred that allows,  or after notice or lapse of time would allow,  revocation
or  termination of such NeoStem  Licenses,  other than any such failure to be in
compliance with such  obligations or any such revocation or termination as would
not,  singly or in the aggregate  with all such other  failures,  revocations or
terminations,  have a NeoStem  Material  Adverse Effect.  Except as set forth in
Section 4.7 of the NeoStem Disclosure Statement, NeoStem has no knowledge of any
facts or  circumstances  that  could  reasonably  be  expected  to  result in an
inability of NeoStem or any of its  Subsidiaries  to renew any material  NeoStem
License.  Subject to making  all  filings,  notifications  and  disclosures  and
receipt of all permits,  authorizations,  consents and approvals  referred to in
Section  4.3.1 of the NeoStem  Disclosure  Statement,  neither the execution and
delivery by NeoStem or Subco of this  Agreement nor the  consummation  of any of
the  transactions   contemplated   herein  will  result  in  any  revocation  or
termination of any material NeoStem License.


                                      -30-


      4.8 Registration Statement;  Prospectus/Joint Proxy Statement. None of the
information  supplied or to be supplied by NeoStem for inclusion in, and none of
the information regarding NeoStem and its Subsidiaries incorporated by reference
in,  the  Registration   Statement  or  the  Prospectus/Joint  Proxy  Statement,
including all  amendments and  supplements  thereto,  shall,  in the case of the
Registration   Statement,   at  the  time  the  Registration  Statement  becomes
effective, and, in the case of the Prospectus/Joint Proxy Statement, on the date
or dates the Prospectus/Joint Proxy Statement is first mailed to NeoStem and CBH
stockholders  and on the date or dates of the NeoStem Annual Meeting and the CBH
Special  Meeting,  contain any untrue  statement  of a material  fact or omit to
state a material  fact  required to be stated  therein or  necessary in order to
make the statements  therein, in the light of the circumstances under which they
were made, not misleading.  The Registration  Statement and the Prospectus/Joint
Proxy  Statement  will  comply  as to form in all  material  respects  with  the
applicable  provisions of the  Securities  Act and the Exchange Act, as the case
may be.

      4.9 Finders or Brokers;  Compensation Arrangements.  Except as provided in
Section  4.9 of the  NeoStem  Disclosure  Statement,  neither  NeoStem  nor  any
Subsidiary  of NeoStem has employed any  investment  banker,  broker,  finder or
intermediary in connection with the transactions  contemplated  hereby who might
be entitled to a fee or any  commission  the receipt of which is  conditioned in
whole or part upon consummation of the Merger.

      4.10 SEC  Reports.  NeoStem  has filed all forms,  reports  and  documents
required to be filed by it with the SEC since  December  31, 2007 (the  "NeoStem
Audit Date")  (including,  without  limitation,  NeoStem's Annual Report on Form
10-K for the year ended  December 31, 2007 filed with the SEC on March 28, 2008,
as amended by Amendment No. 1 to the Annual Report on Form 10-K/A filed with the
SEC on April 29,  2008,  and  NeoStem's  Quarterly  Report on Forms 10-Q for the
quarters ended March 31 and June 30, 2008 and all  certifications and statements
required by Rule 13a-14 or 15d-14 under the  Exchange  Act or 18 U.S.C.  Section
1350  (Section  906  of  SOX)  with  respect  to any  Annual  Reports  or  Proxy
Statements, and Current Reports on Form 8-K), pursuant to the federal securities
laws and the SEC's rules and regulations  thereunder,  and SOX and all rules and
regulations thereunder  (collectively,  and together with all forms, reports and
documents  filed by NeoStem with the SEC after December 31, 2007,  including any
amendments thereto,  the "NeoStem SEC Reports").  Except as set forth in Section
4.10 of the NeoStem Disclosure  Statement,  NeoStem SEC Reports were or will, as
applicable,  be prepared in accordance  with the  requirements of the Securities
Act and the  Exchange  Act,  as the case may be,  and the rules and  regulations
thereunder.  As  of  their  respective  dates,  none  of  NeoStem  SEC  Reports,
including,  without limitation,  any financial  statements or schedules included
therein,  contained or will contain,  as applicable,  any untrue  statement of a
material fact or omitted to state a material fact required to be stated  therein
or  necessary  in  order  to  make  the  statements  therein,  in  light  of the
circumstances  under  which  they were or are made,  as  applicable,  made,  not
misleading.  No  Subsidiary of NeoStem is or has been required to file any form,
report, registration statement or other document with the SEC.


                                      -31-


      4.11 Disclosure  Controls and  Procedures.  NeoStem  maintains  disclosure
controls  and  procedures  required by Rule 13a-15 or 15d-15  under the Exchange
Act.  Such  controls and  procedures  are  effective to ensure that all material
information  concerning  NeoStem and its  Subsidiaries is made known on a timely
basis to the individuals  responsible  for the preparation of NeoStem's  filings
with the SEC and other  public  disclosure  documents.  As used in this  Section
4.11, the term "file" shall be broadly  construed to include any manner in which
a document or information is furnished,  supplied or otherwise made available to
the SEC.

      4.12  Financial  Statements.  Except as set forth in  Section  4.12 of the
NeoStem Disclosure  Statement,  the consolidated  balance sheets and the related
consolidated  statements of income and cash flows  (including  the related notes
thereto)  of NeoStem  included in NeoStem SEC  Reports,  as of their  respective
dates, complied in all material respects with applicable accounting requirements
and the published  rules and regulations of the SEC with respect  thereto,  were
prepared  in  accordance  with U.S.  generally  accepted  accounting  principles
applied on a basis  consistent  with prior  periods  (except as otherwise  noted
therein),  and  present  fairly  in  all  material  respects,  the  consolidated
financial  position of NeoStem  and its  consolidated  Subsidiaries  as of their
respective  dates,  and the  consolidated  results of their operations and their
cash  flows  for the  periods  presented  therein  (subject,  in the case of the
unaudited interim financial statements, to notes and normal year-end adjustments
that were not material in amount or effect).

      4.13  SOX  Certifications.  The  Chief  Executive  Officer  and the  Chief
Financial Officer of NeoStem have signed,  and NeoStem has furnished to the SEC,
all certifications  required by Sections 302 and 906 of SOX. Such certifications
contain no  qualifications  or exceptions to the matters  certified  therein and
have not been modified or withdrawn.  Neither NeoStem nor any of it officers has
received notice from any Governmental  Authority  questioning or challenging the
accuracy,  completeness,  form  or  manner  of  filing  or  submission  of  such
certifications.

      4.14  Undisclosed  Liabilities.  Except  (i)  as  reflected  in  NeoStem's
unaudited  consolidated balance sheet at June 30, 2008 or liabilities  described
in any notes thereto,  (ii) for  liabilities  incurred in the ordinary course of
business since June 30, 2008 consistent with past practice or in connection with
this  Agreement  or the  transactions  contemplated  hereby,  (iii)  performance
obligations  under  contracts  required  in  accordance  with  their  terms,  or
performance  obligations,  to the extent required under applicable laws, in each
case to the extent arising after the date hereof or (iv) as set forth in Section
4.14  of the  NeoStem  Disclosure  Statement,  neither  NeoStem  nor  any of its
Subsidiaries has any material  liabilities or obligations of any nature (whether
accrued,  absolute,  contingent or otherwise) and which,  individually or in the
aggregate,  could  reasonably  be  expected to have a Company  Material  Adverse
Effect.


                                      -32-


      4.15 Off-Balance Sheet Arrangements. NeoStem and its Subsidiaries have not
effected any securitization transactions or "off-balance sheet arrangements" (as
defined in Item 303(c) of  Regulation  S-K of the SEC) since the  NeoStem  Audit
Date. NeoStem has delivered or made available to CBH copies of the documentation
creating or governing any such securitization transactions and off-balance sheet
arrangements.

      4.16  Loans to  Executives  and  Directors.  NeoStem  has not,  since  the
effective date of SOX, extended or maintained credit, arranged for the extension
of credit,  or renewed an extension of credit, in the form of a personal loan to
or for any director or executive  officer (or equivalent  thereof) of NeoStem in
violation of SOX.  NeoStem has not made any loan or extension of credit to which
the second sentence of Section 13(k)(I) of the Exchange Act applies.

      4.17  Independent  Auditors.  Holtz  Rubenstein  Reminick  LLP  serves  as
NeoStem's  independent  registered  public  accounting  firm  and  to  NeoStem's
knowledge, there are no relationships or services, or any other factors that may
affect the objectivity and independence of Holtz  Rubenstein  Reminick LLP under
applicable auditing  standards.  Holtz Rubenstein Reminick LLP has not performed
any non-audit  services for NeoStem and its Subsidiaries since the NeoStem Audit
Date,  which,  in any such case,  were  required to be  disclosed in NeoStem SEC
Reports and were not so disclosed.

      4.18  Absence  of  Changes or  Events.  Except  for (a)  matters  publicly
disclosed by NeoStem prior to the date hereof in NeoStem SEC Reports filed prior
to the date  hereof,  (b)  matters  disclosed  in  Section  4.18 of the  NeoStem
Disclosure  Statement  and (c) matters  disclosed in Section 4.21 of the NeoStem
Disclosure Statement:

            4.18.1 Since  December 31,  2007:  (i) NeoStem and its  Subsidiaries
have conducted  their business in the ordinary  course and have not entered into
any material oral or written agreement or other material transaction that is not
in the ordinary  course of business  (other than this  Agreement)  or that could
reasonably  be expected to result in a NeoStem  Material  Adverse  Effect;  (ii)
neither NeoStem nor any of its Subsidiaries  have sustained any material loss or
interference  with their  business or properties  from fire,  flood,  windstorm,
accident, strike or other calamity (whether or not covered by insurance);  (iii)
there  has been no  material  change  in the  indebtedness  of  NeoStem  and its
Subsidiaries,  no change in the  capital  stock of NeoStem  and no  dividend  or
distribution  of any kind declared,  paid or made by NeoStem on any class of its
capital  stock;  (iv)  there has been no event or  condition  which has caused a
NeoStem  Material Adverse Effect,  nor any  development,  occurrence or state of
facts or circumstances  known to NeoStem that could, singly or in the aggregate,
reasonably be expected to result in a NeoStem Material  Adverse Effect;  and (v)
there has been no  material  change by  NeoStem  in its  accounting  principles,
practices or methods.


                                      -33-


            4.18.2 Since December 31, 2007, other than in the ordinary course of
business  consistent  with past  practice  or as  disclosed  in the  NeoStem SEC
Reports,  there has not been any increase in the  compensation or other benefits
payable,  or which could  become  payable,  by NeoStem,  to its  officers or key
employees, or any amendment of any of the NeoStem Employee Benefit Plans.

      4.19 Capitalization.

            4.19.1  Subject  to  Section   4.19.1  of  the  NeoStem   Disclosure
Statement,   the  authorized   capital  stock  of  NeoStem  consists  solely  of
500,000,000  shares of common  stock,  par value $0.001 per share (the  "NeoStem
Common Stock"),  and 5,000,000 shares of preferred stock, without par value (the
"NeoStem Preferred  Stock"),  of which 825,000 shares are designated as Series B
Convertible  Preferred Stock ("NeoStem Series B Preferred Stock"). As of October
31, 2008,  there were 7,315,006 shares of NeoStem Common Stock and 10,000 shares
of NeoStem Series B Preferred Stock outstanding; and no shares of NeoStem Common
Stock or shares of NeoStem Series B Preferred Stock held in NeoStem's  treasury.
As of October 31, 2008,  6,716,297  shares of NeoStem Common Stock were reserved
for issuance upon the exercise or conversion of outstanding options, warrants or
convertible securities granted or issuable by NeoStem. Except for the foregoing,
as disclosed in the NeoStem SEC  Documents or as set forth below,  there are not
any existing options, warrants, calls,  subscriptions,  or other rights or other
agreements  or  commitments  obligating  NeoStem to issue,  transfer or sell any
shares of capital stock of NeoStem or any other  securities  convertible into or
evidencing the right to subscribe for any such shares;  provided,  however, that
(i) any and all  outstanding  options to purchase shares of NeoStem Common Stock
and/or  warrants to purchase shares of NeoStem Common  immediately  prior to the
Closing,  may be  amended,  canceled  and  reissued,  or  otherwise  modified by
NeoStem's Board of Directors (or an appropriate  committee  thereof) so that the
exercise  price of each  such  option  and/or  warrant  shall be as set forth in
Section 4.19 of the NeoStem Disclosure  Statement;  and (ii) simultaneously with
the  Closing,  any and all  outstanding  options to  purchase  shares of NeoStem
Common Stock held by employees,  officers,  directors or  consultants  providing
services to NeoStem  immediately  prior to the Closing  shall be amended so that
vesting  is  based  on the  achievement  of  certain  milestones.  There  are no
outstanding  stock  appreciation  rights with  respect to the  capital  stock of
NeoStem.  As of the date hereof,  except for (a) stock options issuable pursuant
to stock  option  plans  adopted or assumed  by  NeoStem,  (b) shares of NeoStem
Common Stock issuable pursuant to other NeoStem Employee Benefit Plans disclosed
in NeoStem SEC Reports,  (c)  securities  issuable in  connection  with business
combinations  disclosed in NeoStem SEC Reports, (d) matters described in Section
4.18 of the  NeoStem  Disclosure  Statement  and (e) matters  described  in this
Section 4.19,  NeoStem is not bound by any outstanding  subscriptions,  options,
warrants,  calls,  commitments  or agreements  of any character  calling for the
purchase or issuance of any shares of NeoStem Common Stock or NeoStem  Preferred
Stock or any other equity  securities of NeoStem or any securities  representing
the right to purchase or otherwise receive any shares of NeoStem Common Stock or
NeoStem Preferred Stock or any other equity securities of NeoStem.

            4.19.2  Except  as set  forth  in  Section  4.19.2  of  the  NeoStem
Disclosure Statement, there are no (i) obligations,  contingent or otherwise, of
NeoStem or its  Subsidiaries  to  repurchase,  redeem or  otherwise  acquire any
shares of NeoStem  Common Stock or provide  funds to, or make any  investment in
(in the form of a loan,  capital  contribution  or  otherwise),  or provide  any
guarantee  with  respect  to the  obligations  of,  any  other  person,  or (ii)
agreements,   arrangements  or  commitments  of  any  character  (contingent  or
otherwise)  pursuant  to which any person is or may be  entitled  to receive any
payment  based on the  revenues  or  earnings  (or any  component  thereof),  or
calculated in accordance therewith, of NeoStem or any of its Subsidiaries. There
are no voting trusts,  proxies or other  agreements or  understandings  to which
NeoStem is a party or by which  NeoStem  is bound with  respect to the voting of
any shares of capital stock of NeoStem.


                                      -34-


            4.19.3  NeoStem has delivered or made  available to CBH complete and
correct copies of each stock option plan adopted or assumed by NeoStem as of the
date  hereof  and  the  form  of  equity   compensation   plan  currently  under
consideration  as a proposal  for  adoption  at the NeoStem  Annual  Meeting(the
"Equity Compensation Plan").

            4.19.4 Each  outstanding  share of NeoStem  Common Stock and NeoStem
Preferred  Stock is, and all shares of NeoStem Common Stock and NeoStem Series C
Preferred  Stock to be issued in connection with the  transactions  contemplated
hereby  will  be,  duly   authorized   and  validly   issued,   fully  paid  and
nonassessable,  with no personal  liability  attaching to the ownership thereof,
and each outstanding  share of NeoStem Common Stock and NeoStem  Preferred Stock
has not been,  and all  shares of  NeoStem  Common  Stock and  NeoStem  Series C
Preferred  Stock to be issued in connection with the  transactions  contemplated
hereby  will not be,  subject to or issued in  violation  of any  preemptive  or
similar rights.

      4.20  Capital  Stock  of   Subsidiaries.   The  only  direct  or  indirect
Subsidiaries  of  NeoStem  are  those  listed  in  Section  4.20 of the  NeoStem
Disclosure  Statement.   NeoStem  is  directly  or  indirectly  the  record  and
beneficial  owner of all of the  outstanding  shares of capital stock of each of
its  Subsidiaries,  there are no proxies with respect to such shares,  and there
are not any existing options, warrants, calls, subscriptions, or other rights or
other agreements or commitments  obligating  NeoStem or any of such Subsidiaries
to  issue,  transfer  or  sell  any  shares  of  capital  stock  of any of  such
Subsidiaries or any other securities convertible into or evidencing the right to
subscribe  for any such  shares.  All of such  shares so  beneficially  owned by
NeoStem are duly authorized and validly issued,  fully paid,  nonassessable  and
free of  preemptive  rights  with  respect  thereto  and are  owned by  NeoStem,
directly or indirectly,  free and clear of any claim, lien or encumbrance of any
kind with  respect  thereto.  Except as set forth in Section 4.20 of the NeoStem
Disclosure  Statement,  NeoStem does not directly or indirectly own any interest
in any corporation,  partnership,  limited liability  company,  joint venture or
other business association or entity.

      4.21  Litigation.  Except  as set  forth in  Section  4.21 of the  NeoStem
Disclosure  Statement or in the NeoStem SEC Reports, as of the date hereof there
are no material  pending  actions,  suits,  proceedings  or, to the knowledge of
NeoStem,   investigations  by,  against  or  affecting   NeoStem,   any  of  its
Subsidiaries or any of their properties,  assets or operations,  or with respect
to which NeoStem or any of its  Subsidiaries  is responsible by way of indemnity
or  otherwise.  Except as set forth in Section  4.21 of the  NeoStem  Disclosure
Statement  or the  NeoStem  SEC  Reports:  (i) no  material  pending  or, to the
knowledge of NeoStem,  threatened actions, suits,  proceedings or investigations
by,  against  or  affecting  NeoStem,  any of its  Subsidiaries  or any of their
properties,  assets or operations, or with respect to which they are responsible
by way of indemnity or  otherwise,  whether or not disclosed in such NeoStem SEC
Reports,  would, singly or in the aggregate with all such other actions,  suits,
investigations or proceedings, reasonably be expected to have a NeoStem Material
Adverse  Effect;  and (ii) to the  knowledge  of NeoStem,  there are no material
actions, suits,  proceedings or investigations and there is no reasonable basis,
to the knowledge of NeoStem, for any action, suit,  proceeding or investigation,
whether or not threatened or contemplated.


                                      -35-



      4.22  Insurance.  NeoStem and its  Subsidiaries  have  insurance  policies
covering  it and its  Subsidiaries'  assets,  business,  equipment,  properties,
operations,  employees,  officers and directors which NeoStem  reasonably and in
good faith  believes  are  adequate to conduct  the  business of NeoStem and its
Subsidiaries.  All premiums due and payable  under all such  policies  have been
paid, and NeoStem is otherwise in full  compliance with the terms and conditions
of all such policies,  except where the failure to have made payment or to be in
full compliance would not,  individually or in the aggregate with all such other
failures,  have a NeoStem Material Adverse Effect.  NeoStem reasonably  believes
that the reserves  established by NeoStem and its Subsidiaries in respect of all
matters as to which NeoStem or any of its  Subsidiaries  self-insures or carries
retention and/or  deductibles,  including  without  limitation  workers' medical
coverage and workers' compensation, are adequate and appropriate, and NeoStem is
not aware of any facts or  circumstances  existing  as of the date  hereof  that
would reasonably be expected to cause such reserves to be materially  inadequate
or inappropriate.

      4.23 Title to and Condition of  Properties.  NeoStem and its  Subsidiaries
have good title to all of the real property and personal  property  reflected on
NeoStem's  June 30, 2008  unaudited  consolidated  balance  sheet  contained  in
NeoStem's  Quarterly  Report on Form 10-Q for the  quarter  ended June 30,  2008
filed with the SEC (the "NeoStem Balance Sheet"), except for property since sold
or otherwise  disposed of in the ordinary course of business and consistent with
past  practice and except for defects of title which are not material to NeoStem
and  its  Subsidiaries  taken  as a  whole.  Neither  NeoStem  nor  any  of  its
Subsidiaries  owns any material  real  property.  Except as set forth in Section
4.23 of the NeoStem Disclosure Statement,  no real or personal property owned or
leased by NeoStem  or any of its  Subsidiaries  is  subject to claims,  liens or
other  encumbrances  of any kind or character,  including,  without  limitation,
mortgages,  pledges,  liens,  conditional  sale  agreements,  charges,  security
interests,  easements,  restrictive covenants,  rights of way or options, except
for (i) liens for taxes not yet delinquent or which are being  contested in good
faith  by  appropriate  proceedings  and in  respect  of  which  NeoStem  or its
appropriate  Subsidiary  has  set  aside  on  its  books  adequate  reserves  in
accordance  with generally  accepted  accounting  principles;  (ii)  mechanics',
carriers',  workers',  repairers',  materialmen's,  landlords' and other similar
statutory or common law liens  incurred in the  ordinary  course of business for
obligations  not yet  delinquent or the validity of which is being  contested in
good faith by  appropriate  proceedings  and in respect of which  NeoStem or its
appropriate  Subsidiary  has  set  aside  on  its  books  adequate  reserves  in
accordance with generally accepted accounting  principles;  (iii) in the case of
real  property,  easements,  rights  of  way,  restrictions,  minor  defects  or
irregularities  in title that do not  individually  or in the  aggregate  have a
material  adverse  effect  on the value or use of the real  property  encumbered
thereby as  currently  used in the  operation  of the business of NeoStem or its
Subsidiaries;  (iv) those which would not materially  interfere with the conduct
of the business of NeoStem and its Subsidiaries (the  encumbrances  described in
clauses (i) through (iv) of this sentence,  collectively, the "NeoStem Permitted
Encumbrances");  (v) those securing liabilities reflected in the NeoStem Balance
Sheet;  or (vi)  those  described  in  Section  4.23 of the  NeoStem  Disclosure
Statement.


                                      -36-


      4.24 Leases.  There have been  delivered or made available to CBH true and
complete  copies of each lease  pursuant  to which  Real  Property  or  personal
property is held under lease by NeoStem or any of its Subsidiaries  (limited, in
the case of personal  property,  to leases  pursuant to which annual rentals are
reasonably  expected to be at least  $100,000  per year),  and true and complete
copies of each lease pursuant to which NeoStem or any of its Subsidiaries leases
real or personal  property to others (limited in the case of personal  property,
to leases  pursuant to which  annual  rentals are  reasonably  expected to be at
least $100,000 per year).  Section 4.24 of the NeoStem Disclosure Statement sets
forth a true and complete list of all such leases,  and such leases are the only
leases  that  are  material  to  the  business  conducted  by  NeoStem  and  its
Subsidiaries  taken as a whole.  All of the  leases  so listed  (i) are,  in all
material  respects,  valid and  subsisting  and in full  force and  effect  with
respect to NeoStem and its  Subsidiaries,  as the case may be, and, to NeoStem's
knowledge, with respect to any other party thereto and (ii) were entered into as
a result of bona fide arm's length  negotiations with the other party or parties
thereto.  NeoStem or its Subsidiaries,  as the case may be, have valid leasehold
interests in all  properties  leased  thereunder  free and clear of all material
liens and  encumbrances  other than  NeoStem  Permitted  Encumbrances.  The real
properties leased by NeoStem and its Subsidiaries are, in all material respects,
in good  operating  order and  condition,  subject to ordinary wear and tear. To
NeoStem's  knowledge,  there are no  material  structural,  mechanical  or other
defects in any improvements located on such real properties.

      4.25 Contracts and Commitments. Except as set forth in Section 4.25 of the
NeoStem  Disclosure  Statement,  as  described in a NeoStem SEC Report or as set
forth as an exhibit in a NeoStem  SEC  Report,  neither  NeoStem  nor any of its
Subsidiaries  is a party to any existing  contract,  obligation or commitment of
any type in any of the following categories:

            4.25.1  contracts  for  the  purchase  by  NeoStem  or  any  of  its
Subsidiaries  of  medicines,  materials,  supplies  or  equipment  which are not
cancelable  upon 90 days' or less  notice  and  which  either  (i) have not been
entered  into in the  ordinary  course  of  business  and  consistent  with past
practice or (ii) provide for purchase  prices  substantially  greater than those
presently  prevailing  for  such  materials,  supplies  or  equipment,  or (iii)
contracts obligating NeoStem or its Subsidiaries to make capital expenditures in
excess of $50,000;

            4.25.2 contracts under which NeoStem or any of its Subsidiaries has,
except by way of  endorsement  of negotiable  instruments  for collection in the
ordinary course of business and consistent with past practice, become absolutely
or contingently or otherwise liable for (i) the performance of any other person,
firm or  corporation  under a  contract,  or (ii)  the  whole or any part of the
indebtedness or liabilities of any other person, firm or corporation;


                                      -37-


            4.25.3  powers of attorney  outstanding  from  NeoStem or any of its
Subsidiaries  other  than as  issued in the  ordinary  course  of  business  and
consistent  with past  practice  with  respect to  customs,  insurance,  patent,
trademark or tax matters, or to agents for service of process;

            4.25.4 contracts under which any amount payable by NeoStem or any of
its  Subsidiaries  is dependent  upon, or calculated  in  accordance  with,  the
revenues  or  earnings  (or  any  component  thereof  of  NeoStem  or any of its
Subsidiaries;

            4.25.5 contracts with any director,  officer,  employee or affiliate
of NeoStem or any of its Subsidiaries  other than in such person's capacity as a
director, officer or employee of NeoStem or any of its Subsidiaries;

            4.25.6 contracts which limit or restrict where NeoStem or any of its
Subsidiaries  may conduct its  business or the type or line of business in which
NeoStem or any of its Subsidiaries may engage;

            4.25.7   contracts   with  any  party  for  the  loan  of  money  or
availability  of credit to or from  NeoStem or any of its  Subsidiaries  (except
credit  extended by NeoStem or any of its  Subsidiaries  to its customers in the
ordinary course of business and consistent with past practice);

            4.25.8 any material  hedging,  option,  derivative  or other similar
transaction; or

            4.25.9 any contract with any Governmental Authority or, to NeoStem's
knowledge,  any Government Authority  contractor,  with regard to any product or
service sold or provided by NeoStem.

True and complete copies of all contracts, obligations and commitments listed in
Section 4.25 of the NeoStem  Disclosure  Statement  have been  delivered or made
available to CBH. Except as set forth in Section 4.25 of the NeoStem  Disclosure
Statement,  none of NeoStem or its Subsidiaries or, to the knowledge of NeoStem,
any  other  party  is in  breach  of or  default  under  any of  the  contracts,
obligations  and  commitments  listed in Section 4.25 of the NeoStem  Disclosure
Statement  or under  any other  NeoStem  Contracts  (and,  to the  knowledge  of
NeoStem,  no facts or  circumstances  exist which could  reasonably  support the
assertion of any such breach or default)  except for breaches and defaults which
would  not,  singly or in the  aggregate  with all other such  breaches,  have a
NeoStem Material Adverse Effect.

      4.26 Employees;  Labor Matters. Except as set forth in Section 4.26 of the
NeoStem  Disclosure  Statement,  neither NeoStem nor any Subsidiary thereof is a
party to or bound by any collective bargaining agreement, and there are no labor
unions  or  other  organizations   representing,   purporting  to  represent  or
attempting  to represent  any  employees  employed by NeoStem or any  Subsidiary
thereof.  Since December 31, 2007, there has not occurred or been threatened any
material strike, slowdown,  picketing, work stoppage,  concerted refusal to work
overtime or other  similar  labor  activity  with  respect to any  employees  of
NeoStem or any  Subsidiary  thereof.  Except as set forth in Section 4.26 of the
NeoStem Disclosure  Statement,  there are no labor disputes currently subject to
any  grievance   procedure,   arbitration   or   litigation   and  there  is  no
representation  petition  pending or threatened  with respect to any employee of
NeoStem or any  Subsidiary  thereof.  Each of NeoStem and its  Subsidiaries  has
complied with all Applicable Laws pertaining to the employment or termination of
employment of their respective  employees,  including,  without limitation,  all
such   Applicable   Laws   relating  to  labor   relations,   equal   employment
opportunities,   fair  employment   practices,   prohibited   discrimination  or
distinction and other similar employment  activities,  except for any failure so
to comply  that,  individually  and in the  aggregate,  could not  result in any
material  liability  or  obligation  on  the  part  of  NeoStem  or  any  of its
Subsidiaries.


                                      -38-


      4.27 Put  Rights.  Except as  described  in  Section  4.27 of the  NeoStem
Disclosure  Statement,  neither the  execution  and  delivery by NeoStem of this
Agreement  nor  the  consummation  of  the  Merger  or  any  other   transaction
contemplated  hereby  gives  rise to any  obligation  of  NeoStem  or any of its
Subsidiaries to, or any right of any holder of any security of NeoStem or any of
its Subsidiaries to require NeoStem to, purchase,  offer to purchase,  redeem or
otherwise prepay or repay any such security,  or deposit any funds to effect the
same.

      4.28 Employment and Labor  Contracts.  Except as set forth in Section 4.28
of the NeoStem Disclosure Statement,  as described in a NeoStem SEC Report or as
set forth as an exhibit in a NeoStem SEC Report,  neither NeoStem nor any of its
Subsidiaries is a party to any employment,  management services, consultation or
other  contract  or  agreement  with any past or present  officer,  director  or
employee or, to the knowledge of NeoStem, any entity affiliated with any past or
present  officer,  director or employee,  other than the agreements  executed by
employees generally,  the forms of which have been provided or made available to
CBH.

      4.29 Intellectual Property Rights. NeoStem or its Subsidiaries own or have
the right to use all material NeoStem  Intellectual  Property Rights (as defined
herein) necessary to conduct their respective  businesses.  Subject to obtaining
any associated consents with respect to agreements or licenses listed in Section
4.29 of the NeoStem Disclosure  Statement,  each NeoStem  Intellectual  Property
Right owned or used by NeoStem or any of its Subsidiaries  immediately  prior to
the Effective Time will be owned or available for use, in all material respects,
by NeoStem or its  Subsidiaries on  substantially  the same terms and conditions
immediately  subsequent  to the  Effective  Time.  Section  4.29 of the  NeoStem
Disclosure  Statement  contains a list of all  material  patents,  trade  names,
registered copyrights, trademarks and service marks, mask works and applications
for the foregoing  owned or used by NeoStem or its  Subsidiaries.  Except as set
forth in Section 4.29 of the NeoStem  Disclosure  Statement,  (i) NeoStem and/or
its  Subsidiaries  have valid and  unencumbered  (except for  NeoStem  Permitted
Encumbrances)  title to the NeoStem  Intellectual  Property  Rights set forth in
such  Section  4.29  and,  to  NeoStem's  knowledge,  such  title  has not  been
challenged  (pending or threatened) by others except for the encumbrances listed
therein;  (ii) no  material  rights  or  licenses  to use  NeoStem  Intellectual
Property  Rights have been  granted or acquired by NeoStem or its  Subsidiaries;
(iii) there have been no claims or assertions made by others that NeoStem or its
Subsidiaries  has infringed any  Intellectual  Property  Rights of others by the
sale of products, the rendering of services or any other activity since December
31, 2007; (iv) to the knowledge of NeoStem,  there has been no such infringement
by NeoStem or any of its  Subsidiaries  since December 31, 2007; (v) NeoStem has
no knowledge of any  infringement  of NeoStem  Intellectual  Property  Rights of
NeoStem or any of its Subsidiaries by others; and (vi) all NeoStem  Intellectual
Property Rights owned by NeoStem or its  Subsidiaries  are in good standing with
the registration  authority therefor, if any, and, to the extent recorded on the
public record, are recorded in the name of NeoStem or its Subsidiaries. True and
complete copies of all material listed in Section 4.29 of the NeoStem Disclosure
Statement  have been  delivered  or made  available to CBH. For purposes of this
Agreement,  the phrase  "NeoStem  Intellectual  Property  Rights" shall mean the
Intellectual Property Rights of NeoStem and its Subsidiaries.


                                      -39-


      4.30 Taxes.

            4.30.1 Except as set forth in Section 4.30 in the NeoStem Disclosure
Statement,  (i) all  Returns  required  to be filed by, or with  respect  to any
activities or assets of, each of NeoStem and its Subsidiaries have been duly and
timely  filed and are correct and complete in all  material  respects,  (ii) all
Taxes shown as owing on such Returns have been paid and (iii) none of NeoStem or
its  Subsidiaries  is currently the  beneficiary of any extension of time within
which to file any Return.

            4.30.2 Except as set forth in Section 4.30 of the NeoStem Disclosure
Statement, (i) all Taxes that are or may become payable by any of NeoStem or its
Subsidiaries  or  chargeable  as an  Encumbrance  upon its  assets for which the
filing of a Return is not required  have been duly and timely paid and (ii) each
of NeoStem and its  Subsidiaries has duly and timely withheld all Taxes required
to be withheld in  connection  with the business or assets of such  entity,  and
such  withheld  Taxes  have  been  either  duly and  timely  paid to the  proper
governmental authorities or properly set aside in accounts for such purpose.

            4.30.3 Except as set forth in Section 4.30 of the NeoStem Disclosure
Statement,  there has been no claim or issue  (other  than a claim or issue that
has been finally  settled)  concerning any liability for Taxes of NeoStem or any
Subsidiary  thereof asserted,  raised or threatened by any taxing authority and,
to the knowledge of NeoStem and its Subsidiaries, no circumstances exist to form
the basis for such a claim or issue.

            4.30.4 Section 4.30 of the NeoStem  Disclosure  Statement  lists all
Income Tax Returns  that have been filed with respect to each of NeoStem and its
Subsidiaries for taxable periods ended on or after January 1, 2006 and that have
not yet been audited or are currently the subject of audit.

            4.30.5 Except as set forth in Section 4.30 of the NeoStem Disclosure
Statement,  none of NeoStem or its  Subsidiaries  has (i) waived any  statute of
limitations,  (ii)  agreed to any  extension  of the  period for  assessment  or
collection  or (iii)  executed  or filed any power of attorney  with  respect to
Taxes, which waiver, agreement or power of attorney is currently in force.

            4.30.6 Except as set forth in Section 4.30 of the NeoStem Disclosure
Statement,  (i) there are no  outstanding  adjustments  for Income Tax  purposes
applicable to NeoStem or any of its Subsidiaries required as a result of changes
in methods of  accounting  effected on or before the date of this  Agreement and
(ii) no  material  elections  for Income Tax  purposes  have been made by any of
NeoStem  or its  Subsidiaries  that are  currently  in force or by which  any of
NeoStem or its Subsidiaries is bound.


                                      -40-


            4.30.7 Except as set forth in Section 4.30 of the NeoStem Disclosure
Statement,  none of NeoStem or its Subsidiaries (i) is a party to or bound by or
has any  obligation  under any Tax  allocation,  sharing,  indemnity  or similar
agreement  or  arrangement  or (ii) is or has  been a  member  of any  group  of
companies filing a consolidated, combined or unitary Income Tax Return.

      4.31 Employee Benefit Plans.

            4.31.1 Except as set forth in Section 4.31 of the NeoStem Disclosure
Statement,  with  respect to any  employee or former  employee of NeoStem or any
Subsidiary thereof, none of NeoStem or any Subsidiary thereof, or any affiliated
company presently maintains,  contributes to or has any liability under: (i) any
bonus,  incentive  compensation,  profit  sharing,  retirement,  pension,  group
insurance, death benefit,  cafeteria,  medical expense reimbursement,  dependent
care,  stock  option,  stock  purchase,   stock  appreciation  rights,  deferred
compensation,  consulting,  severance  pay or  termination  pay,  vacation  pay,
welfare  or  other  employee   benefit  or  fringe  benefit  plan,   program  or
arrangement;  or (ii) any plan,  program  or  arrangement  which is an  employee
pension  benefit  plan, or an "employee  welfare  benefit plan" as defined under
relevant laws.  Each plan,  program and arrangement set forth in Section 4.31 of
the NeoStem  Disclosure  Statement is herein referred to as a "NeoStem  Employee
Benefit Plan." The term "affiliated  company" means any organization  that would
be  aggregated  with any of  NeoStem or any  Subsidiary  thereof  under  Section
414(b), (c), (m) or (o) of the Code.

            4.31.2  There is no  pending  or  threatened  legal  action,  claim,
proceeding or  investigation  against or involving any NeoStem  Employee Benefit
Plan  (other than  routine  claims for  benefits)  and there is no basis for any
facts  which  could  give  rise to any  such  condition,  legal  action,  claim,
proceeding or investigation.

            4.31.3  Except  as set  forth  in  Section  4.31.3  of  the  NeoStem
Disclosure  Statement,  none of NeoStem or any Subsidiary thereof nor any of its
Affiliates is a party to any employment  agreement,  whether written or oral, or
agreement  with  change  in  control  or  similar  provisions,  or a  collective
bargaining  agreement or contract with any labor union relating to any employees
or former employees of NeoStem or any Subsidiary thereof.

      4.32 Environmental Matters.

            4.32.1 Each of NeoStem and its  Subsidiaries  has complied and is in
compliance  in all material  respects  with all  applicable  Environmental  Laws
pertaining to any of the properties  and assets of NeoStem and its  Subsidiaries
(including  all real  property  owned  by  NeoStem  or any of its  Subsidiaries,
together  with all  structures,  facilities,  improvements,  fixtures,  systems,
equipment  and items of  property  presently  or  hereafter  located  thereon or
attached or appurtenant  thereto or owned by NeoStem or any of its  Subsidiaries
and located on real property leased by NeoStem or any of its  Subsidiaries,  and
all  easements,  licenses,  rights and  appurtenances  relating to the foregoing
(collectively  the "NeoStem Real Property")) and the use and ownership  thereof,
and to the operation of their respective  businesses.  No material  violation by
NeoStem  or  any  of  its  Subsidiaries  is  being  alleged  of  any  applicable
Environmental Law relating to any of the properties and assets of NeoStem or any
of its  Subsidiaries  including  (the  NeoStem  Real  Property)  or  the  use or
ownership thereof, or to the operation of their respective businesses.


                                      -41-


            4.32.2  None of  NeoStem  or its  Subsidiaries  or any other  Person
(including  any tenant or  subtenant)  has caused or taken any action  that will
result in, nor is NeoStem or any  Subsidiary  thereof  subject to, any  material
liability or obligation on the part of NeoStem or any Subsidiary  thereof or any
of its Affiliates,  relating to (x) the  environmental  conditions on, under, or
about the NeoStem Real Property or other  properties  or assets  owned,  leased,
operated  or used  by  NeoStem  or any of its  Subsidiaries  or any  predecessor
thereto at the present time or in the past,  including without  limitation,  the
air,  soil and  groundwater  conditions  at such  properties  or (y) the past or
present use, management,  handling, transport,  treatment,  generation, storage,
disposal or Release of any Hazardous materials.

                  4.32.2.1  NeoStem has disclosed and made  available to CBH all
information,  including,  without  limitation,  all  studies,  analyses and test
results, in the possession,  custody or control of or otherwise known to NeoStem
relating  to (x) the  environmental  conditions  on,  under  or  about  the Real
Property  or other  properties  or assets  owned,  leased,  operated  or used by
NeoStem or any of its  Subsidiaries  any predecessor in interest  thereto at the
present time or in the past,  and (y) any  Hazardous  materials  used,  managed,
handled,  transported,  treated, generated, stored or Released by NeoStem or any
of its  Subsidiaries  or any other  Person on,  under,  about or from any of the
NeoStem Real Property,  or otherwise in connection  with the use or operation of
any of the properties and assets of NeoStem or any of its  Subsidiaries or their
respective businesses.

      4.33 Disclosure.  All information  disclosed by or on behalf of NeoStem or
its  Subsidiaries  to CBH or its advisers on or prior to the date hereof is true
and accurate in all material aspects, and NeoStem is not aware of any other fact
or matter which renders any such information misleading because of any omission,
ambiguity or for any other reason.  All information  contained in the Disclosure
Statement is true and accurate in all aspects and fairly  presented and there is
no fact or  matter  which  has not  been  disclosed  in the  NeoStem  Disclosure
Statement which renders any such  information  untrue or misleading and there is
no fact or matter  concerning  NeoStem or its Subsidiaries  which has not on the
basis  of the  utmost  good  faith  been  disclosed  in the  NeoStem  Disclosure
Statement which would reasonably be expected to influence the decision of CBH to
proceed with the Merger on the terms and conditions thereof.

      4.34 NeoStem is currently listed on the American Stock Exchange, Inc. (the
"AMEX") and will get the shares of NeoStem  Common  Stock  required to be issued
pursuant to this  Agreement  listed on the AMEX,  the New York Stock  Exchanges,
Inc.  or the  NASDAQ  Stock  Market  (each,  an  "Exchange")  at the time of the
Closing.


                                      -42-


                                   ARTICLE V.

                            COVENANTS OF THE PARTIES

      5.1 Access and Information.

            5.1.1 Prior to the Closing,  and except for disclosures  which would
cause CBH or any of its Subsidiaries to waive the  attorney-client  privilege or
otherwise  violate  Applicable  Law or any material  confidentiality  agreement,
NeoStem shall be entitled to make or cause to be made such  investigation of CBH
and its Subsidiaries,  and the financial and legal condition thereof, as NeoStem
deems necessary or advisable,  and CBH and its Subsidiaries shall cooperate with
any such investigation.  In furtherance of the foregoing,  but not in limitation
thereof,  CBH shall (a) permit  NeoStem  and its agents and  representatives  or
cause them to be  permitted to have full and  complete  access to the  premises,
operating  systems,  computer  systems  (hardware  and  software)  and books and
records  of CBH and its  Subsidiaries  upon  reasonable  notice  during  regular
business  hours,  (b) furnish or cause to be furnished to NeoStem such financial
and operating data, projections,  forecasts, business plans, strategic plans and
other data relating to CBH and its  Subsidiaries and their businesses as NeoStem
shall request from time to time  (including the plant  re-location  and capacity
expansion plan of Erye) and (c) cause its  accountants to furnish to NeoStem and
its accountants access to all work papers relating to any of the periods covered
by financial statements provided by CBH or Erye to NeoStem hereunder.

            5.1.2 Prior to the Closing,  and except for disclosures  which would
cause NeoStem or any of its Subsidiaries to waive the attorney-client  privilege
or otherwise violate Applicable Law or any material  confidentiality  agreement,
NeoStem  shall (a) provide  complete  and  accurate  information  to CBH and its
representatives in response to reasonable requests for information made in order
to enable  CBH to  confirm  the  accuracy  of the  representations  set forth in
Article IV (including the continuing accuracy of those representations which are
not made as of a particular  date) and the  fulfillment of the covenants of this
Article V and the closing  conditions in Sections 6.1 and 6.3 and (b) furnish to
CBH complete and accurate  information  comparable  to the types of  information
heretofore  furnished  by NeoStem  to CBH in  connection  with the  transactions
contemplated hereby and such other information as CBH may reasonably request (in
light of prevailing circumstances).

            5.1.3 Prior to the Closing,  NeoStem  shall not use any  information
provided  to it in  confidence  by  CBH  for  any  purposes  unrelated  to  this
Agreement.  CBH shall not use any  information  provided to it in  confidence by
NeoStem for any  purposes  unrelated to this  Agreement.  Except with respect to
publicly  available  documents,  in the event that this Agreement is terminated,
(a)  NeoStem  will return to CBH all  documents  obtained by it from CBH and its
Subsidiaries  in confidence  and any copies thereof in the possession of NeoStem
or its agents and  representatives  or, at the option of NeoStem,  NeoStem shall
cause all of such  documents  and all of such copies to be  destroyed  and shall
certify  the  destruction  thereof to CBH and (b) CBH will return to NeoStem all
documents obtained by it from NeoStem and its Subsidiaries in confidence and any
copies thereof in the possession of CBH or its agents and representatives or, at
the option of CBH, CBH shall cause all of such  documents and all of such copies
to be  destroyed  and shall  certify  the  destruction  thereof to  NeoStem.  No
investigation  by NeoStem or CBH  heretofore  or hereafter  made shall modify or
otherwise  affect  the  conditions  to the  obligation  of  NeoStem  and  CBH to
consummate the transactions contemplated hereby.


                                      -43-


      5.2 CBH's Affirmative Covenants. Prior to the Closing, except as otherwise
expressly  provided herein,  CBH shall (and CBH shall cause each of Erye and its
other Subsidiaries to):

            5.2.1 conduct its business  only in the ordinary and regular  course
of business consistent with past practices;

            5.2.2 use commercially  reasonable efforts to keep in full force and
effect its corporate existence and all material rights, franchises, Intellectual
Property Rights and goodwill relating or pertaining to its businesses;

            5.2.3  endeavor to retain its  employees  and  preserve  its present
relationships   with  customers,   suppliers,   contractors,   distributors  and
employees,  and  continue  to  compensate  its  employees  consistent  with past
practices;

            5.2.4  use  commercially  reasonable  efforts  to  maintain  the CBH
Intellectual  Property  Rights so as not to affect  adversely  the  validity  or
enforcement  thereof;  maintain its other assets in customary repair,  order and
condition and maintain insurance reasonably  comparable to that in effect on the
date of this Agreement;

            5.2.5  maintain its books,  accounts and records in accordance  with
generally accepted accounting principles;

            5.2.6  use   commercially   reasonable   efforts   to   obtain   all
authorizations,  consents,  waivers,  approvals or other actions and to make all
filings and  applications  necessary or desirable to consummate the transactions
contemplated hereby, including,  without limitation,  applications to the Suzhou
Bureau  of  Foreign   Trade  and   Economic   Cooperation   Foreign   Investment
Administration  Department  (the  "SBFTEC")  for the  SBFTEC's  approval  of the
transfer of stock equity in Erye  contemplated by this  Agreement,  and to cause
the other conditions to NeoStem's obligation to close to be satisfied;

            5.2.7   promptly   notify  NeoStem  in  writing  if,  prior  to  the
consummation of the Closing, to its knowledge (a) any of the representations and
warranties  contained  in Article III cease to be accurate  and  complete in all
material  respects  (except for any  representation  and  warranty  (i) which is
qualified  hereunder as to materiality,  as to which such notification  shall be
given if CBH or its Subsidiaries  obtain knowledge that such  representation and
warranty is inaccurate in any respect, or (ii) that addresses matters only as of
a particular  date,  which need only be true and correct as of such date) or (b)
CBH  fails to  comply  with or  satisfy  any  material  covenant,  condition  or
agreement to be complied with or satisfied by it hereunder;  provided,  however,
that the delivery of any notice  pursuant to this Section  5.2.7 shall not limit
or otherwise affect the remedies available hereunder to NeoStem; and

            5.2.8  cause  the  consolidated   balance  sheets  and  the  related
consolidated  statements of income and cash flows  (including  the related notes
thereto)  of CBH  included  in CBH SEC  Reports  filed  after the date hereof to
comply, in all material respects,  with applicable  accounting  requirements and
the  published  rules and  regulations  of the SEC with respect  thereto,  to be
prepared,  in accordance  with U.S.  generally  accepted  accounting  principles
applied on a basis  consistent  with prior  periods  (except as otherwise  noted
therein),  and to present fairly,  in all material  respects,  the  consolidated
financial  position  of  CBH  and  its  consolidated  Subsidiaries  as of  their
respective  dates,  and the  consolidated  results of their operations and their
cash  flows  for the  periods  presented  therein  (subject,  in the case of the
unaudited interim financial statements, to notes and normal year-end adjustments
that are not reasonably expected to be, material in amount or effect).


                                      -44-


      5.3  NeoStem's  Affirmative  Covenants.  Prior to the  Closing,  except as
otherwise expressly provided herein, NeoStem shall (and NeoStem shall cause each
of its Subsidiaries to):

            5.3.1 Conduct its business  only in the ordinary and regular  course
of business consistent with past practices;

            5.3.2 use commercially  reasonable efforts to keep in full force and
effect its corporate existence and all material rights,  franchises, the NeoStem
Intellectual   Property  rights  and  goodwill  relating  or  obtaining  to  its
businesses;

            5.3.3  endeavor to retain its  employees  and  preserve  its present
relationships   with  customers,   suppliers,   contractors,   distributors  and
employees,  and  continue  to  compensate  its  employees  consistent  with past
practice,  which has included equity  compensation  particularly where available
cash has been limited;

            5.3.4  maintain its books,  accounts and records in accordance  with
generally accepted accounting principles;

            5.3.5  use   commercially   reasonable   efforts   to   obtain   all
authorizations,  consents,  waivers,  approvals or other actions and to make all
filings and  applications  necessary or desirable to consummate the transactions
contemplated  hereby and to cause the other  conditions  to CBH's  obligation to
close to be satisfied; and

            5.3.6 promptly  notify CBH in writing if, prior to the  consummation
of the Closing,  to its knowledge (a) any of the  representations and warranties
contained  in Article  IV cease to be  accurate  and  complete  in all  material
respects  (except for any  representation  and  warranty  (i) which is qualified
hereunder as to  materiality,  as to which such  notification  shall be given if
NeoStem  or its  Subsidiaries  obtain  knowledge  that such  representation  and
warranty is inaccurate in any respect, or (ii) that addresses matters only as of
a particular  date,  which need only be true and correct as of such date) or (b)
NeoStem  fails to comply with or satisfy any  material  covenant,  condition  or
agreement to be complied with or satisfied by it hereunder;  provided,  however,
that the delivery of any notice  pursuant to this Section  5.3.5 shall not limit
or otherwise affect the remedies available hereunder to CBH;

            5.3.7  cause  the  consolidated   balance  sheets  and  the  related
consolidated  statements of income and cash flows  (including  the related notes
thereto) of NeoStem  included in NeoStem SEC Reports filed after the date hereof
to comply, in all material respects, with applicable accounting requirements and
the  published  rules and  regulations  of the SEC with respect  thereto,  to be
prepared,  in accordance  with U.S.  generally  accepted  accounting  principles
applied on a basis  consistent  with prior  periods  (except as otherwise  noted
therein),  and to present fairly,  in all material  respects,  the  consolidated
financial  position of NeoStem  and its  consolidated  Subsidiaries  as of their
respective  dates,  and the  consolidated  results of their operations and their
cash  flows  for the  periods  presented  therein  (subject,  in the case of the
unaudited interim financial statements, to notes and normal year-end adjustments
that are not reasonably expected to be, material in amount or effect).


                                      -45-


      5.4 CBH's Erye's  Negative  Covenants.  Prior to the Closing,  without the
prior written consent of NeoStem or as otherwise  expressly provided herein, CBH
will not, and CBH will cause Erye and its other Subsidiaries not to:

            5.4.1 take any action or omit to take any action  which would result
in CBH's or any of its  Subsidiaries'  (a) incurring any trade accounts  payable
outside of the ordinary  course of Business or making any commitment to purchase
quantities of any item of inventory in excess of quantities  normally  purchased
in the ordinary course of business;  (b) increasing any of its  indebtedness for
borrowed money except in the ordinary course of business;  (c)  guaranteeing the
obligations  of any  entity  other  than  CBH's  Subsidiaries,  (d)  merging  or
consolidating with, purchasing  substantially all of the assets of, or otherwise
acquiring  any  business  or  any  proprietorship,  firm,  association,  limited
liability company,  corporation or other business  organization;  (e) making any
representation to anyone indicating any intention of NeoStem or its Subsidiaries
to retain,  institute,  or provide any  employee  benefit  plans;  (f) after the
Registration Statement and/or Joint Proxy Statement is filed, issuing any shares
of the capital stock of any kind of CBH or its  Subsidiaries,  transferring from
the treasury of CBH or its  Subsidiaries  any shares of the capital stock of CBH
or its Subsidiaries, except for CBH Common Stock issuable upon exercise of a CBH
Stock  Option,  CBH Warrant or RimAsia CBH Warrant  outstanding  on December 31,
2007;  (g) issuing or granting any  subscriptions,  options,  rights,  warrants,
convertible securities or other agreements or commitments to issue, or contracts
or any other  agreements  obligating  CBH or its  Subsidiaries  to issue,  or to
transfer  from  treasury,  any shares of capital  stock of any class or kind, or
securities  convertible  into  any  such  shares;  (h)  modifying,  amending  or
terminating  any  material CBH  Contract  other than in the  ordinary  course of
business that is  consistent  with past  practices;  (i) entering into any other
transaction  outside of the  ordinary  course of  business,  except that CBH may
extend the terms of or enter into new management  and consulting  agreements and
vendor relationships, or make strategic investments; (j) declaring or paying any
dividend or making any distribution with respect to, or purchasing or redeeming,
shares of the capital  stock of CBH; or (k) selling or  disposing  of any assets
otherwise than in the ordinary course of business of CBH and its Subsidiaries;

            5.4.2 change any method or principle of  accounting in a manner that
is inconsistent  with past practice,  except to the extent required by generally
accepted   accounting   principles  as  advised  by  CBH's  regular  independent
accountants;

            5.4.3   take  any   action   that   would   likely   result  in  the
representations   and   warranties   set  forth  in  Article   III  (other  than
representations  made as of a particular  date)  becoming false or inaccurate in
any material respect (or, as to representations and warranties,  which, by their
terms,  are  qualified as to  materiality,  becoming  false or inaccurate in any
respect);


                                      -46-


            5.4.4 incur or create any encumbrances,  liens,  pledges or security
interests on assets other than CBH Permitted Encumbrances;

            5.4.5 except as contemplated herein, take any action or omit to take
any action which would  materially  interfere  with  NeoStem's  rights to compel
performance of each of the obligations of CBH under this Agreement;

            5.4.6  take or omit to be taken any  action,  or  permit  any of its
affiliates  to take or to omit to take any  action,  which would  reasonably  be
expected to result in a CBH Material Adverse Effect;

            5.4.7  grant  or  otherwise  issue  any  option,  warrant  or  other
securities  exercisable  for or  convertible  into shares of CBH Common Stock or
other capital stock of CBH; or

            5.4.8 agree or commit to take any action  precluded  by this Section
5.4.

      5.5 NeoStem's Negative Covenants.  Prior to the Closing, without the prior
written consent of CBH or as otherwise  expressly provided herein,  NeoStem will
not and NeoStem will cause its Subsidiaries not to:

            5.5.1 except as set forth in the last paragraph of this Section 5.5,
take any action or omit to take any action  which would  result in  NeoStem's or
any of its Subsidiaries' (a) incurring any trade accounts payable outside of the
ordinary  course of Business or making any commitment to purchase  quantities of
any item of inventory in excess of quantities normally purchased in the ordinary
course of business, other than costs associated with research and development of
very small embryonic-like (VSEL) stem cell technology and the establishment of a
new research and development laboratory;  (b) increasing any of its indebtedness
for borrowed money except in the ordinary course of business;  (c)  guaranteeing
the obligations of any entity other than NeoStem's  Subsidiaries;  (d) declaring
or paying any dividend or making any distribution with respect to, or purchasing
or redeeming,  shares of the capital stock of NeoStem;  (e) selling or disposing
of any assets  otherwise than in the ordinary  course of business of NeoStem and
its Subsidiaries; (f) making any capital expenditures other than in the ordinary
course of business  consistent  with past practices and in no event in excess of
$100,000  individually,  excluding  capital  expenditures  associated  with  the
purchase of a flowcytometer and/or  cryopreservation tanks; or (g) entering into
any other  transaction  outside of the ordinary course of business,  except that
NeoStem  may  extend the terms of or enter into new  management  and  consulting
agreements  and vendor  relationships,  or make  strategic  investments;  or (h)
merging or consolidating with, purchasing substantially all of the assets of, or
otherwise  acquiring  any  business or any  proprietorship,  firm,  association,
limited liability company,  corporation or other business  organization,  except
for the merger  contemplated  by this  Agreement  and the  acquisition  with Red
Cross;


                                      -47-


            5.5.2 change any method or principle of  accounting in a manner that
is inconsistent  with past practice,  except to the extent required by generally
accepted  accounting  principles  as advised by  NeoStem's  regular  independent
accountants;

            5.5.3   take  any   action   that   would   likely   result  in  the
representations   and   warranties   set  forth  in  Article   IV  (other   than
representations  made as of a particular  date)  becoming false or inaccurate in
any material respect (or, as to representations and warranties,  which, by their
terms,  are  qualified as to  materiality,  becoming  false or inaccurate in any
respect);

            5.5.4 except as contemplated herein, take any action or omit to take
any  action  which  would  materially  interfere  with  CBH's  rights  to compel
performance of each of the obligations of NeoStem under this Agreement;

            5.5.5  take or omit to be taken any  action,  or  permit  any of its
affiliates  to take or to omit to take any  action,  which would  reasonably  be
expected to result in a NeoStem Material Adverse Effect;

            5.5.6 amend NeoStem's  certificate of incorporation or by-laws, each
as  amended,  in any  material  manner that does not  generally  apply to all of
NeoStem's stockholders; or

            5.5.7 agree or commit to take any action  precluded  by this Section
5.5.

            Notwithstanding  any  provision  to the  contrary  contained in this
Agreement, in no event shall NeoStem be prohibited from engaging in or otherwise
effecting,  and shall be expressly  permitted to engage in or otherwise  effect,
any of the following  transactions:  (i) the  transactions  contemplated by this
Agreement,  including,  without  limitation,  the  Merger,  the  change  in  the
composition  of the  NeoStem  Board  of  Directors  and the  entrance  into  the
Employment  Agreements,   the  Consultant  Agreement  and  the  CBC  Non-Compete
Agreement  (each, as defined  herein);  (ii) the merger or  consolidation  with,
purchase  of  substantially  all of the assets of, or other  acquisition  of any
business or any proprietorship,  firm,  association,  limited liability company,
corporation or other business organization so that that parties can move forward
with an acquisition of the business of Shangdong  Institute (as defined herein),
if  appropriate;  (iii) a stock split,  reclassification,  combination  or other
change with  respect to shares of NeoStem  Common Stock that may be necessary or
appropriate for NeoStem to comply with any Exchange listing standards; provided,
that the  Exchange  Ratio shall be  adjusted  to reflect  any such stock  split,
reclassification,  combination or other change; (iv) the amendment,  cancelation
and  reissuance  or other  modification  of any and all  outstanding  options to
purchase  shares of NeoStem Common Stock and/or  warrants to purchase  shares of
NeoStem Common Stock immediately  prior to the Closing,  so that (a) any and all
outstanding  options to purchase  shares of NeoStem Common Stock and/or warrants
to purchase shares of NeoStem Common  immediately  prior to the Closing,  may be
amended,  canceled and  reissued,  or otherwise  modified by NeoStem's  Board of
Directors (or an  appropriate  committee  thereof) so that the exercise price of
each such option  and/or  warrant  shall be as set forth in Section  4.19 of the
NeoStem Disclosure  Statement,  and (b) simultaneously with the Closing, any and
all  outstanding  options to  purchase  shares of NeoStem  Common  Stock held by
employees,  officers,  directors or  consultants  providing  services to NeoStem
immediately  prior to the Closing  shall be amended so that  vesting is based on
the  achievement of certain  milestones;  (v) a financing  transaction,  whether
through the private  placement of securities  of NeoStem or otherwise;  (vi) the
adoption  of the  Equity  Compensation  Plan or (vii) at the  discretion  of the
Compensation  Committee of the NeoStem  Board of  Directors,  the grant or other
issuance  of options to  purchase  up to an  aggregate  of  1,000,000  shares of
NeoStem  Common  Stock under the Equity  Compensation  Plan or any other  equity
compensation  plan as bonuses in connection with the closing of the transactions
contemplated by this Agreement.


                                      -48-


      5.6 Closing Documents. CBH shall, prior to or on the Closing Date, execute
and deliver, or cause to be executed and delivered,  to NeoStem the documents or
instruments  described in Section 5.2. NeoStem shall, prior to or on the Closing
Date,  execute and deliver,  or cause to be executed and  delivered,  to CBH the
documents or instruments described in Section 5.3.

      5.7  Further  Actions.  Each  of the  parties  hereto  agrees  to use  all
reasonable  efforts to take,  or cause to be taken,  all actions,  and to do, or
cause to be done,  and to assist and cooperate  with the other parties in doing,
all things necessary,  proper or advisable to consummate and make effective,  in
the most  expeditious  manner  practicable  in light of the  circumstances,  the
Merger and the other  transactions  contemplated  by this  Agreement,  including
without  limitation  (A)  the  obtaining  of  all  other  necessary  actions  or
nonactions,  waivers, consents,  licenses, permits,  authorizations,  orders and
approvals from  Governmental  Authorities  and the making of all other necessary
registrations  and  filings,  (B) the  obtaining of all  consents,  approvals or
waivers from third parties  related to or required in connection with the Merger
that are necessary to consummate the Merger and the transactions contemplated by
this Agreement or required to prevent a NeoStem Material Adverse Effect or a CBH
Material Adverse Effect from occurring prior to or after the Effective Time, (C)
the preparation of the  Prospectus/Joint  Proxy  Statement and the  Registration
Statement, the declaration of effectiveness of the Registration Statement by the
SEC and the mailing of the Prospectus/Joint  Proxy Statement to the stockholders
of NeoStem  and CBH,  (D) if  necessary  as a result of the  circumstances,  the
amendment of the Registration  Statement and Prospectus/Joint Proxy Statement as
required by law and (E) the execution and delivery of any additional instruments
necessary to consummate the transactions contemplated by, and to fully carry out
the purposes of, this Agreement.

      5.8 Board of Directors and Officers of NeoStem.

            (i)  NeoStem  shall use its  reasonable  best  efforts  to cause the
members  of the Board of  Directors  to consist of the  following  five  members
promptly  following the Effective Time: Robin Smith,  Madam Zhang Jian,  Richard
Berman, Steven S. Myers and Joseph Zuckerman (the latter three to be independent
directors,  as defined under the American  Stock  Exchange  listing  standards).
Within four months  following the Effective  Time,  NeoStem's Board of Directors
shall,  in accordance  with NeoStem's  bylaws,  as amended,  cause the number of
members constituting the Board of Directors of NeoStem to be increased from five
to seven  and to fill the two  vacancies  created  thereby  with a  designee  of
RimAsia,  who shall initially be Eric Wei, and with an independent  director (as
defined under the American Stock Exchange listing standards) to be selected by a
nominating committee of the Board of Directors of NeoStem.


                                      -49-


            (ii) It is anticipated that the key members of NeoStem's  management
team will remain in place following the Effective Time.

      5.9 Public Announcements.  Unless otherwise required by Applicable Laws or
requirements  of any  Exchange  on which the NeoStem  Common  Stock is quoted or
listed (and in that event only if time does not  permit),  at all times prior to
the earlier of the Effective Time or  termination of this Agreement  pursuant to
Section 7.1,  NeoStem and CBH shall  consult with each other before  issuing any
press  release  with  respect  to the  Merger and shall not issue any such press
release prior to such consultation.

      5.10 Stockholders' Meetings.

            5.10.1 NeoStem Annual Meeting. Subject to Article VII, NeoStem shall
take all action in accordance  with the federal  securities  law, the DGCL,  the
applicable  rules of the Exchange on which the NeoStem Common Stock is listed or
quoted,  NeoStem's  certificate  of  incorporation,  as amended,  and  NeoStem's
by-laws, as amended,  necessary to convene the NeoStem Annual Meeting to be held
on the earliest  practical date as reasonably  determined by NeoStem in light of
the  circumstances,  and  to  obtain  the  consent  and  approval  of  NeoStem's
stockholders with respect to the issuance of the Exchanged  Securities  pursuant
to the Merger,  including (in the absence of  conditions  that would justify the
termination  of  this  Agreement)   recommending   such  approval  to  NeoStem's
stockholders.

            5.10.2 CBH Special  Meeting.  Subject to Article VII, CBH shall take
all action in  accordance  with the federal  securities  laws,  the DGCL,  CBH's
certificate  of  incorporation,  as  amended,  and CBH's  by-laws,  as  amended,
necessary  to  convene  the CBH  Special  Meeting  to be  held  on the  earliest
practical   date  as   reasonably   determined   by  NeoStem  in  light  of  the
circumstances, and to obtain the consent and approval of CBH's stockholders with
respect to this Agreement and the transactions  contemplated  hereby,  including
(in the  absence  of  conditions  that would  justify  the  termination  of this
Agreement) recommending such approval to CBH's stockholders.

      5.11  Preparation  of  the   Prospectus/Joint   Proxy  Statement  and  the
Registration Statement.


                                      -50-


            5.11.1  NeoStem,  CBH  and  CBC  shall,  as  soon  as is  reasonably
practicable,  cooperate to prepare the  Prospectus/Joint  Proxy  Statement to be
included in the Registration Statement. Once NeoStem, CBH and CBC consent to the
filing of the Prospectus/Joint Proxy Statement with the SEC (which consent shall
not be unreasonably  withheld),  NeoStem shall file the  Prospectus/Joint  Proxy
Statement with the SEC,  which filing shall be made on a  confidential  basis to
the extent permitted by the regulations of the SEC with respect to such filings.
Consistent  with the timing for the NeoStem  Annual  Meeting and the CBH Special
Meeting as determined by NeoStem in accordance with Section 5.10, NeoStem shall,
subject  to  the  consent  of CBH  and  CBC  (which  shall  not be  unreasonably
withheld),  prepare and file the Registration  Statement with the SEC as soon as
is reasonably  practicable  following  clearance of the  Prospectus/Joint  Proxy
Statement  by the SEC and  reasonable  approval  of the  Prospectus/Joint  Proxy
Statement by CBH, CBC and NeoStem and shall use all  reasonable  efforts to have
the  Registration  Statement  declared  effective  by  the  SEC as  promptly  as
practicable  thereafter and to maintain the  effectiveness  of the  Registration
Statement  through the  Effective  Time.  If, at any time prior to the Effective
Time, NeoStem, CBH or CBC shall obtain knowledge of any information contained in
or omitted from the  Registration  Statement  that would require an amendment or
supplement  to  the  Registration   Statement  or  the  Prospectus/Joint   Proxy
Statement,  the party obtaining such knowledge will promptly so advise the other
parties in writing and each of CBH,  CBC and  NeoStem  will  promptly  take such
action as shall be required to amend or supplement  the  Registration  Statement
and/or the Prospectus/Joint Proxy Statement.  Each of CBH and CBC shall promptly
furnish to NeoStem all financial and other  information  concerning it as may be
required  for  the  Prospectus/Joint  Proxy  Statement  and any  supplements  or
amendments thereto.  NeoStem,  CBH and CBC shall cooperate in the preparation of
the  Prospectus/Joint  Proxy  Statement  in a timely  fashion  and shall use all
reasonable  efforts  to  clear  the  Prospectus/Joint  Proxy  Statement  and the
Registration   Statement  with  the  Staff  of  the  SEC.   Promptly  after  the
Registration  Statement is declared  effective by the SEC,  each of CBH, CBC and
NeoStem  shall use all  reasonable  efforts to mail at the earliest  practicable
date to its  stockholders  the  Prospectus/Joint  Proxy  Statement,  which shall
include all information  required under  Applicable Law to be furnished to CBH's
stockholders  and  NeoStem's  stockholders  in connection  with the Merger,  the
Spin-Off and the  transactions  contemplated  thereby and shall  include the CBH
Board  Recommendation.  NeoStem  also shall take such other  reasonable  actions
(other than qualifying to do business in any  jurisdiction in which it is not so
qualified  or  submitting  to  taxation in any  jurisdiction  in which it is not
subject to taxation)  required to be taken under any applicable state securities
laws in connection  with the issuance of NeoStem Common Stock and NeoStem Series
C Preferred  Stock in the Merger.  Notwithstanding  any provision  herein to the
contrary,  prior  to the  time  that  the  Registration  Statement  is  declared
effective,  the  Prospectus/Joint  Proxy  Statement  shall  contain  the audited
consolidated financial statements described in clause "a" of Section 5.16.1.

            5.11.2 (a)  Notwithstanding  anything contained in this Agreement to
the  contrary,  NeoStem  shall not be obligated to take any action under Section
5.11.1  unless  and until the  following  conditions  shall  have been met:  (i)
NeoStem shall have received the audited financial statements of CBH and Erye and
any  other  financial  information  of  CBH  or its  Subsidiaries  required  for
inclusion in the  Registration  Statement,  (ii) NeoStem shall have received pro
forma financial statements approved by CBH, Erye and its auditors required to be
included in the  Registration  Statement,  under SEC rules,  (iii) NeoStem shall
have received such auditor comfort letters from its, CBH's and Erye's  auditors,
tax and other legal  opinions  from CBH's  counsel,  the PRC Opinion (as defined
herein)  and (iv)  NeoStem  shall have  received  the opinion of vFinance to the
effect that the terms of the Merger are fair to  NeoStem's  stockholders  from a
financial  point of view  (the  "NeoStem  Fairness  Opinion"),  each in form and
substance reasonably satisfactory to NeoStem.

            (b)  While  it  is  the  Parties'   understanding   that  the  joint
preparation and filing with the SEC of the Prospectus/Joint  Proxy Statement and
Registration  Statement  by  NeoStem,  CBH  and  CBC is  permissible  under  the
Securities  Act and the Exchange Act and the rules and  regulations  promulgated
thereunder,  there  can be no  assurance  that the SEC will  permit  such  joint
filings.  Accordingly,  notwithstanding  anything contained in this Agreement to
the  contrary,  NeoStem  shall not be obligated to take any action under Section
5.11.1 with respect to the  registration  under the  Securities Act of shares of
CBC Common Stock to be issued  pursuant to the Spin-Off if and to the extent the
inclusion in the Prospectus/Joint  Proxy Statement and/or Registration Statement
of such  registration is not permitted by the SEC. In such event, CBC shall file
a separate  registration  statement  under the  Securities  Act  relating to the
registration  of the shares of CBC  Common  Stock to be issued  pursuant  to the
Spin-Off.


                                      -51-


      5.12  Merger  Subsidiary.  Prior to the  Effective  Time,  Subco shall not
conduct  any  business  or make  any  investments  other  than  as  specifically
contemplated  by this  Agreement  and will not have any assets  (other than a de
minimis  amount of cash paid to Subco for the  issuance of its stock to NeoStem)
or any material liabilities.

      5.13 Exchange Listing.  NeoStem shall use its reasonable  efforts to cause
the NeoStem Common Stock  issuable  pursuant to the Merger  (including,  without
limitation,  the NeoStem  Common Stock  issuable upon  conversion of the NeoStem
Series C Preferred  Stock or the  exercise of the Series B or C Warrants)  to be
approved  for  listing on an  Eligible  Market,  subject to  official  notice of
issuance, prior to the Effective Time.

      5.14 CBH Lock-Up and Voting Agreement and Support Agreement.  Concurrently
herewith, NeoStem, CBH, each director and officer of CBH, RimAsia, Erye, EET and
Dr. Wang Taihua and the holder of CBH Series A Preferred  stock has entered into
the CBH Lock-Up and Voting Agreement. Concurrently herewith CBH shall deliver to
NeoStem a  Support  Agreement,  in the form  attached  hereto as  Exhibit E (the
"Support Agreement"),  pursuant to which each of EET and Erye has agreed to take
certain  actions in support and  furtherance  of the  transactions  contemplated
hereby.

      5.15 Subsequent Financial Statements. CBH shall consult with NeoStem prior
to making publicly available its financial results for any period after the date
of this Agreement and prior to filing any CBH SEC Reports after the date of this
Agreement.

      5.16 Financial Statements for a Current Report on Form 8-K.

            5.16.1 Prior to the Closing, CBH shall provide, and shall cause Erye
to provide,  to NeoStem (a) regardless of when the Closing  occurs,  (i) audited
consolidated  balance sheets of each of CBH and Erye and its  Subsidiaries as of
December 31, 2007 and 2006, (ii) audited consolidated statements of income, cash
flows  and  changes  in  shareholders'  equity  of each of CBH and  Erye and its
Subsidiaries  for the years ended December 31, 2007, 2006 and 2005, and (iii) an
unqualified  report with respect to such audited  financial  statements by Moore
Stephens Wurth Frazer & Torbet, LLP, which report shall be in form and substance
reasonably  satisfactory  to NeoStem,  and (b) if the Closing occurs on or after
November  14, 2008,  in addition to the items  referred to in clause "a" of this
Section  5.16.1,  (i) unaudited  consolidated  balance sheets of each of CBH and
Erye and its  respective  Subsidiaries  as of September 30, 2008 and 2007,  (ii)
unaudited  consolidated   statements  of  income,  cash  flows  and  changes  in
shareholders' equity of each of CBH and Erye and its respective Subsidiaries for
the three and nine months ended September 30, 2008 and 2007, and (iii) all other
financial  statements  of CBH or Erye required for any SEC filing to be filed by
NeoStem, including, without limitation, pro forma financial statements that give
effect  to  the  Spin-Off.  Such  financial  statements  shall  be  prepared  in
accordance with generally accepted accounting principles,  consistently applied,
and shall  conform  in all  material  respects  to all  provisions  of the SEC's
Regulation  S-X, so that such financial  statements  meet the  requirements  for
filing by NeoStem with the SEC as required by the SEC's  Current  Report on Form
8-K. Prior to the Closing, CBC shall provide to NeoStem all financial statements
of CBC required for any SEC filing to be filed by NeoStem.


                                      -52-



            5.16.2 At the Closing, CBH shall cause Moore Stephens Wurth Frazer &
Torbet,  LLP to deliver to NeoStem an executed  consent,  in form and  substance
reasonably  satisfactory  to NeoStem and suitable for filing by NeoStem with the
SEC,  which  consent  shall  authorize  NeoStem to file with the SEC the reports
delivered pursuant to Section 5.16.1.

            5.16.3 Upon NeoStem's request,  contemporaneous with the delivery of
the consolidated financial statements described in clause "a" of Section 5.16.1,
CBH shall cause Moore Stephens  Wurth Frazer & Torbet,  LLP to make available to
NeoStem and its  representatives  the work papers  generated in connection  with
such accounting firm's audit of the audited  consolidated  financial  statements
delivered pursuant to Section 5.16.1.

            5.16.4 Prior to the Closing,  CBH and CBC shall  cooperate,  and CBH
shall  cause Erye to  cooperate,  with  NeoStem  in  providing  to NeoStem  such
consolidated  financial  statements,  financial data and accountants' reports as
NeoStem shall  reasonably  request with respect to any filing that NeoStem shall
make under the Securities Act or the Exchange Act.

      5.17 CBC Spin-Off.

            5.17.1 CBH has represented that any and all CBH Payable  Obligations
are less than  $450,000 and will be less than  $450,000 as of the Closing  Date.
The parties  have agreed that at or prior to Closing,  CBH shall have  satisfied
all of the CBH Payable  Obligations,  except that CBH Payable Obligations in the
aggregate amount of not more than $225,000 may remain at or after the Closing to
be paid,  satisfied or otherwise  provided for by NeoStem  including within such
$225,000  to be  satisfied  by NeoStem  (a)  NeoStem  shall  satisfy  $97,000 of
liabilities  due to Globus and Mao by the issuance of shares pursuant to Section
2.7 and (b) NeoStem may  negotiate  with any other  creditor  listed on Schedule
3.14(b) of the CBH Disclosure Statement to attempt to settle such liability with
NeoStem  shares  rather  than  cash and to have  such  liability  be part of its
maximum $225,000 obligation hereunder. Neither NeoStem nor the Surviving Company
will have any responsibility for CBH Payable  Obligations in excess of $225,000.
CBH shall take any and all action  necessary or appropriate to obtain a release,
in the form attached hereto as Exhibit F (each, a "CBH Liability Release"), from
each Person to whom any CBH Payable  Obligations  is, or as of the Closing  Date
will be, owed (each, a "CBH Creditor"), pursuant to which each such CBH Creditor
shall  release  NeoStem,  Subco,  CBH and  Erye  from  any  and all CBH  Payable
Obligations except as provided in the prior sentence.


                                      -53-


            5.17.2 CBH shall take any and all action necessary or appropriate to
obtain any and all authorizations, consents, waivers, approvals or other actions
required to be obtained for the Spin-Off.

      5.18 Erye Revenues. Prior to the Closing, CBH shall cause Erye to agree to
contribute to NeoStem 6% of the net annual income  received by Erye,  commencing
with the year ending  December 31, 2009,  in order to fund  NeoStem's  costs and
expenses.

                                  ARTICLE VI.

                                   CONDITIONS

      6.1 Conditions to the  Obligations of Each Party.  The obligations of CBH,
NeoStem and Subco to consummate the Merger shall be subject to the  satisfaction
(or waiver by each  party,  to the  extent  permitted  by law) of the  following
conditions:

            6.1.1  (i)  This   Agreement,   the  Merger  and  the   transactions
contemplated  hereby shall have been approved and adopted by CBH's  stockholders
in the manner  required by any  Applicable  Law,  and (ii) this  Agreement,  the
amendment  of the charter to increase  the  authorized  preferred  stock and the
issuance of the shares of the  Exchanged  Securities  to be issued in the Merger
shall have been  approved by  NeoStem's  stockholders  and NeoStem in the manner
required by any Applicable Law and the applicable rules of the Exchange on which
the NeoStem Common Stock is quoted or listed.

            6.1.2 No Governmental Authority of competent jurisdiction shall have
enacted, issued, promulgated, enforced or entered any statute, rule, regulation,
judgment,  decree,  injunction  or other order  which is in effect,  which would
prohibit  consummation  of the  transactions  contemplated  by this Agreement or
which would have a NeoStem  Material Adverse Effect after the Effective Time and
after giving effect to  consummation  of the  transactions  contemplated by this
Agreement.

            6.1.3  The  SEC  shall  have  declared  the  Registration  Statement
effective  under the  Securities  Act, and no stop order or similar  restraining
order suspending the  effectiveness  of the  Registration  Statement shall be in
effect and no proceedings for such purpose shall be pending before or threatened
by the SEC or any state securities administrator.

            6.1.4 The  shares of  NeoStem  Common  Stock  required  to be issued
pursuant to the Merger (including,  without limitation, the NeoStem Common Stock
issuable  upon the exercise of the Class C Warrants or conversion of the NeoStem
Series C Preferred  Stock) shall have been  approved for listing on the Exchange
on which the  NeoStem  Common  Stock is listed or quoted,  subject  to  official
notice of issuance.

            6.1.5 Each of Robin  Smith and Madam  Zhang Jian shall have  entered
into employment agreements with NeoStem,  effective as of the Effective Time, in
substantially  form and substance  reasonably  acceptable to NeoStem and each of
them of (each, an "Employment Agreement").


                                      -54-


            6.1.6  This  Agreement,  the Erye  Letter of  Intent  to Enter  into
Amended and Restated Joint Venture Agreement, dated as of the date hereof, among
NeoStem,  Subco and Erye  Economy and Trading Co.  Ltd.,  a  Sino-Foreign  joint
venture with limited  liability  organized under the laws of the PRC ("EET"),  a
copy of which is  attached  hereto as Exhibit G (the  "Erye  Letter of Intent to
Enter into  Amended and  Restated  Joint  Venture  Agreement"),  the Amended and
Restated Erye Joint Venture Agreement,  in the form attached hereto as Exhibit H
(the  "Amended  and  Restated  Erye Joint  Venture  Agreement"),  to replace all
existing  agreements  between CBH and EET, and the Articles of  Incorporation of
Erye, as amended in accordance  with Section 6.1.7,  shall have been prepared in
or  translated  into  Chinese by Erye,  and such  Chinese  versions  as shall be
legally  required  shall  have  been  delivered  to the  relevant  PRC and other
governmental  organizations for inspection and approval,  and all such approvals
have been obtained.  NeoStem,  Subco and EET shall have entered into the Amended
and Restated Erye Joint Venture Agreement  simultaneously with Closing and after
such approvals,  and the Amended and Restated Erye Joint Venture Agreement shall
be in full force and effect.  NeoStem, Subco and EET shall have performed all of
its obligations  under this  Agreement,  the Erye Letter of Intent to Enter into
Amended and Restated Joint Venture  Agreement and under the Amended and Restated
Erye Joint Venture Agreement.

            6.1.7 The  organizational  documents  of Erye  shall be amended in a
manner  satisfactory  as to form and  substance  to  NeoStem,  and copies of the
amended organizational documents of Erye shall have been provided to NeoStem.

            6.1.8 The result of any and all due  diligence,  including,  but not
limited to,  legal due  diligence,  financial  due  diligence  and  business due
diligence,  shall  be  satisfactory  to  NeoStem,  in its  sole  discretion.  In
furtherance  of, but without  limiting  the  foregoing,  there shall have been a
review by NeoStem of (i) the plant  relocation  and capacity  expansion  plan of
Erye and (ii) financial  projections  (together with supporting  assumptions) of
Erye, both of which shall be satisfactory to NeoStem, in its sole discretion.

      6.2 Conditions to NeoStem's and Subco's  Obligations.  The  obligations of
NeoStem and Subco to consummate the transactions  contemplated by this Agreement
shall be  subject  to the  fulfillment  (or  waiver by  NeoStem)  prior to or at
Closing of each of the following conditions:

            6.2.1 The representations and warranties of CBH set forth in Article
III  shall  be  true  and  correct  in  all   material   respects   (other  than
representations  and  warranties  which are qualified as to  materiality,  which
representations and warranties shall be true in all respects) on the date hereof
and on and as of the Closing  Date as though made on and as of the Closing  Date
(except for  representations  and warranties made as of a specified date,  which
shall be measured only as of such specified  date),  except where the failure of
such  representations  and warranties to be so true and correct  (without giving
effect to any limitations as to  "materiality"  or a CBH Material Adverse Effect
set  forth  therein)  does  not  have,  and is not  reasonably  likely  to have,
individually or in the aggregate,  a CBH Material Adverse Effect,  provided that
the  representations and warranties set forth in Sections 3.1, 3.2, 3.5 and 3.19
shall be true and correct in all material  respects (other than  representations
and warranties which are qualified as to materiality,  which representations and
warranties  shall be true in all  respects)  on the date hereof and on and as of
the  Closing  Date as though  made on and as of the  Closing  Date  (except  for
representations  and  warranties  made as of a  specified  date,  which shall be
measured as of such specified date).


                                      -55-



            6.2.2 CBH and CBC shall have performed in all material respects each
of its obligations  under this Agreement and shall have complied in all material
respects  with each  covenant to be performed and complied with by it under this
Agreement at or prior to the Closing.

            6.2.3  Since  the  date of this  Agreement,  there  shall  not  have
occurred any act,  event or omission  having or reasonably  likely to have a CBH
Material Adverse Effect.

            6.2.4  CBH,  CBC and Erye shall have  obtained  all  authorizations,
consents,  waivers, approvals or other actions described in Section 6.2.4 of the
CBH Disclosure Statement required in connection with the execution, delivery and
performance of this Agreement by CBH and its Subsidiaries  (the "CBH Approvals")
and the CBH Approvals  shall be in full force and effect as of the Closing Date.
NeoStem shall have obtained all authorizations,  consents, waivers, approvals or
other  actions  described in Section 6.2.4 of the NeoStem  Disclosure  Statement
(the "NeoStem  Approvals") and the NeoStem  Approvals shall be in full force and
effect as of the Closing Date.

            6.2.5 NeoStem will receive at Closing $550,000 of unencumbered  cash
from the LXB litigation settlement.

            6.2.6  There  shall  not be  pending  any  legal  proceeding  by any
Governmental Authority or other third party which (a) in the reasonable judgment
of  NeoStem's  Board of  Directors,  is  reasonably  likely  to cause a  NeoStem
Material  Adverse Effect after the Effective Time giving effect to  consummation
of the transactions contemplated by this Agreement and (b) either (i) challenges
or seeks to restrain or prohibit  the  consummation  of the Merger or any of the
other  transactions  contemplated by this  Agreement,  (ii) seeks to prohibit or
limit the  ownership  or operation  by NeoStem,  CBH or any of their  respective
subsidiaries  of,  or  to  compel  NeoStem,  CBH  or  any  of  their  respective
subsidiaries  to  dispose  of or hold  separate,  any  material  portion  of the
business or assets of NeoStem, CBH or any of their respective subsidiaries, as a
result  of the  Merger  or any of the other  transactions  contemplated  by this
Agreement,  (iii)  seeks to impose  limitations  on the  ability  of  NeoStem to
acquire or hold,  or exercise full rights of ownership of, any shares of capital
stock of the  Surviving  Company or the Erye  Ownership,  including the right to
vote  such  capital  stock of the  Surviving  Company  and  Erye on all  matters
properly presented to the stockholders of the Surviving Company or Erye, or (iv)
seeks  to  prohibit  NeoStem  or any  subsidiary  of  NeoStem  from  effectively
controlling in any material respect the business or operations of NeoStem or the
subsidiaries of NeoStem including the Surviving Company and Erye.

            6.2.7  Prior to or at the  Closing,  CBH  shall  have  delivered  to
NeoStem the following:

                  6.2.7.1  a  certificate  of  the  Chairman  of  CBH  and  Erye
(executed on behalf of CBH and Erye), dated the Closing Date, to the effect that
(1) the person signing such  certificate is familiar with this Agreement and (2)
to such person's  knowledge,  the conditions  specified in Sections 6.2.1, 6.2.2
and 6.2.3 have been satisfied;


                                      -56-



                  6.2.7.2 a certificate of the Secretary or Assistant  Secretary
of CBH and Erye,  dated the Closing Date, as to the incumbency of any officer of
such entity executing this Agreement or any document related hereto; and

                  6.2.7.3 (a) a copy of (1) the certificate of incorporation, as
amended,  of CBH,  certified  by the  Delaware  Secretary of State and dated not
earlier  than  fifteen  days  prior to the  Closing,  (2) a  certificate  of the
Delaware  Secretary  of State,  dated not earlier than fifteen days prior to the
Closing and  confirming  that CBH is in good  standing in the State of Delaware,
(3) the by-laws,  as amended,  of CBH,  certified by the  Secretary or Assistant
Secretary of CBH as of the Closing Date, and (4) the  resolutions of CBH's Board
of  Directors  authorizing  the  execution,  delivery and  consummation  of this
Agreement and the transactions  contemplated hereby,  certified by the Secretary
or  Assistant  Secretary  of CBH as of  the  Closing  Date  and  (b)  comparable
documentation for Erye.

            6.2.8 All reports of CBH's independent accountants relating to CBH's
and Erye's audited consolidated financial statements filed with (or incorporated
by reference in any document  filed with) the SEC  subsequent to the date hereof
and  prior  to the  Effective  Time  shall  certify,  without  qualification  or
exception,  that such financial  statements (a) have been prepared in accordance
with generally accepted accounting  principles  consistently  applied during the
periods  involved  and  (b)  fairly  present,  in  all  material  respects,  the
consolidated  financial  position of the  entities  described  therein as of the
dates thereof and the consolidated  results of operations and consolidated  cash
flows of such entities for the periods presented.

            6.2.9 NeoStem shall have received opinions of PRC counsel to CBH and
its Subsidiaries (the "PRC Opinion") and tax counsel to CBH and its Subsidiaries
(the  "Tax  Opinion"),  in the form and  substance  reasonably  satisfactory  to
NeoStem, including without limitation,  with respect to the Merger, the tax-free
status of the  reorganization,  the spin-off,  the regulatory status of Erye and
the disclosure in the Registration Statement,  respectively.  Such counsel shall
also provide NeoStem with appropriate opinion letters prior to the filing of the
Registration Statement and/or Joint Proxy Statement.

            6.2.10  NeoStem  shall have  received the NeoStem  Fairness  Opinion
prior to the filing of the  Registration  Statement and/or Joint Proxy Statement
and a re-affirmation of such NeoStem Fairness Opinion prior to Closing.

            6.2.11 NeoStem shall have received proof satisfactory to it that CBH
has not less than $550,000 in  unencumbered  cash available for  distribution to
NeoStem and has settled any and all CBH Payable  Obligations  subject to Section
5.17.1.

            6.2.12 NeoStem shall have received proof satisfactory to it that the
Spin-Off has been consummated or is being  consummated  simultaneously  with the
Merger,  and  that all  regulatory,  stockholder  and  other  approvals  for the
Spin-Off have been received by CBH.


                                      -57-


            6.2.13 NeoStem shall have received proof satisfactory to it that all
CBH  Warrants,  RimAsia CBH Warrants and shares of CBH Series A Preferred  Stock
have been terminated and cancelled.

            6.2.14  NeoStem  shall have received (i) a true and complete list of
any and all CBH Payable  Obligations  immediately  prior to the Closing Date and
the name and address of each CBH Creditor thereof; (ii) proof satisfactory to it
that all CBH Payable Obligations have been paid, satisfied or otherwise provided
for or  transferred  to CBC;  and (iii) a CBH  Liability  Release  from each CBH
Creditor.

            6.2.15.  The CBH Lock-Up and Voting Agreement shall be in full force
and effect,  and each  director and officer of each of CBH,  holder of shares of
CBH Series A Preferred Stock,  RimAsia, Erye and EET shall have performed all of
his, her or its obligations under, and shall not have breached any provision of,
the CBH Lock-Up and Voting  Agreement.  The Support  Agreement  shall be in full
force and  effect,  and each of EET and Erye  shall  have  performed  all of its
obligations  under,  and shall not have  breached any  provision of, the Support
Agreement.

            6.2.16.  The Escrow Agreement shall have been executed and delivered
by CBC and the Escrow Agent.

            6.2.17.  All personnel of each of CBH and Erye who will be personnel
of NeoStem, Subco or Erye immediately following the Closing, shall have executed
and delivered to NeoStem a Confidentiality, Invention Assignment and Non-Compete
Agreement,  substantially  in form and  substance  signed by  NeoStem's  current
personnel (the "NeoStem Confidentiality Agreement").

            6.2.18.   Mao  shall  have  executed  and  delivered  to  NeoStem  a
consulting agreement,  effective as of the Effective Time, in form and substance
reasonably  acceptable  to  NeoStem  and  Mao,  which  shall  include,   without
limitation a NeoStem Confidentiality Agreement (the "Consulting Agreement").

            6.2.19.   CBC  shall  have  executed  and  delivered  to  NeoStem  a
non-competition  agreement,  effective  as of the  Effective  Time,  in form and
substance reasonably  acceptable to NeoStem and CBC, pursuant to which CBC shall
agree,  for a period of two (2)  years,  not to engage in stem cell  collection,
storage or therapies. ( the "CBC Non-Compete Agreement").

            6.2.20.  All of the holders of CBH Common  Stock  Purchase  Warrants
shall have agreed in writing to accept the Class C Warrants in exchange  thereof
pursuant to a Class C Warrant Agreement.

            6.2.21.   NeoStem  shall  have  received  evidence  satisfactory  to
NeoStem, in its sole discretion,  of the satisfaction in full of any and all (i)
indebtedness  for borrowed  money payable by CBH to Globus,  including,  without
limitation,  indebtedness in the principal  amount of $50,000,  plus any and all
accrued  but  unpaid  interest  thereon or other  obligations  of CBH to Globus,
including expense reimbursement (collectively, the "Globus Obligation") and (ii)
indebtedness  for  borrowed  money  payable  by CBH to Mao,  including,  without
limitation,  indebtedness in the principal  amount of $40,000,  plus any and all
accrued but unpaid interest thereon or other obligations (the "Mao Obligation").
NeoStem  also  shall  have  received  evidence  satisfactory  to it, in its sole
discretion, of the cancelation of the CBH Series A Preferred Stock.


                                      -58-


            6.2.22. NeoStem shall have received evidence satisfactory to it that
the transfer of stock equity in Erye  contemplated  by this Agreement shall have
been approved by the SBFTEC;  that the Merger shall have been approved by Except
for the  approval of the  competent  authorities  of  commerce  under the Law on
Sino-Foreign Equity Joint Ventures and its implementation regulations;  and that
any and all  requisite  registrations  with the China  State  Administration  of
Foreign Exchange shall have been made.

            6.2.23. NeoStem shall have received evidence reasonably satisfactory
to  it  from  each  relevant  PRC  Governmental   Authority  that  CBH  and  its
Subsidiaries are in compliance in all material  respects with all applicable Tax
Laws and Environmental Laws.

            6.2.24. CBH shall have purchased a six-year prepaid "tail policy" on
terms  and  conditions  (in  both  amount  and  scope)  providing  substantially
equivalent  benefits  as  the  current  policies  of  directors'  and  officers'
liability  insurance  maintained  by CBH and its  Subsidiaries  with  respect to
matters  arising on or before the  Effective  Time,  the cost of which shall not
exceed  150% of the last  annual  premium  paid by CBH prior to the date of this
Agreement  with  respect to its current  policies of  directors'  and  officers'
liability insurance.

            6.2.25.  Erye shall have agreed to  contribute  to NeoStem 6% of the
net annual income received by Erye, commencing with the year ending December 31,
2009,  in  order  to fund  NeoStem's  costs  and  expenses,  including,  without
limitation  the costs and expenses  incurred by NeoStem in  connection  with the
transactions contemplated hereby.

            6.2.26 NeoStem shall have received proof satisfactory to it that PRC
national  candidates  for NeoStem board seats  reasonably  acceptable to NeoStem
have been identified by CBH or Erye and have indicated a willingness to serve.

            6.2.27 Neostem shall be able to consolidate the financial statements
of Erye under GAAP.

      6.3 Conditions to CBH's Obligations.  The obligations of CBH to consummate
the  transactions  contemplated  by  this  Agreement  shall  be  subject  to the
fulfillment  (or  waiver  by  CBH) at or  prior  to the  Closing  of each of the
following conditions:

            6.3.1 The  representations  and  warranties of NeoStem and Subco set
forth in Article IV shall be true and correct in all  material  respects  (other
than representations and warranties which are qualified as to materiality, which
representations and warranties shall be true in all respects) on the date hereof
and on and as of the Closing  Date as though made on and as of the Closing  Date
(except for  representations  and warranties made as of a specified date,  which
shall be measured only as of such specified  date),  except where the failure of
such  representations  and warranties to be so true and correct  (without giving
effect to any  limitations as to  "materiality"  or a NeoStem  Material  Adverse
Effect set forth therein) does not have,  and is not reasonably  likely to have,
individually or in the aggregate,  a NeoStem Material  Adverse Effect,  provided
that the  representations and warranties set forth in Sections 4.1, 4.2 and 4.19
shall be true and correct in all material  respects (other than  representations
and warranties which are qualified as to materiality,  which representations and
warranties  shall be true in all  respects)  on the date hereof and on and as of
the  Closing  Date as though  made on and as of the  Closing  Date  (except  for
representations  and  warranties  made as of a  specified  date,  which shall be
measured as of such specified date).


                                      -59-


            6.3.2  NeoStem  and  Subco  shall  have  performed  in all  material
respects each of its obligations under this Agreement and shall have complied in
all material  respects  with each  covenant to be performed and complied with by
NeoStem and Subco under this Agreement at or prior to the Closing.

            6.3.3 NeoStem  shall have obtained all of the NeoStem  Approvals and
the NeoStem Approvals shall be in full force and effect as of the Closing Date.

            6.3.4  Prior to or at the  Closing,  NeoStem  and Subco  shall  have
delivered to CBH the following:

                  6.3.4.1  a  certificate  of the  Chief  Executive  Officer  of
NeoStem  (executed on behalf of NeoStem),  dated the Closing Date, to the effect
that (1) the person signing such certificate is familiar with this Agreement and
(2) to such person's  knowledge,  the  conditions  specified in Sections  6.3.1,
6.3.2 and 6.3.5 have been satisfied;

                  6.3.4.2 a certificate of the Secretary or Assistant  Secretary
of each of NeoStem and Subco,  dated the Closing Date,  as to the  incumbency of
any  officer of NeoStem  and Subco  executing  this  Agreement  or any  document
related hereto;

                  6.3.4.3 a copy of (1) the  certificate  of  incorporation,  as
amended, of NeoStem,  certified by the Delaware Secretary of State and dated not
earlier  than  fifteen  days  prior to the  Closing,  (2) a  certificate  of the
Delaware  Secretary  of State,  dated not earlier than fifteen days prior to the
Closing  and  confirming  that  NeoStem  is in good  standing  in the  State  of
Delaware, (3) the by-laws, as amended, of NeoStem, certified by the Secretary or
Assistant  Secretary of NeoStem as of the Closing Date, and (4) the  resolutions
of  NeoStem's  Board  of  Directors  (or  committee  thereof)   authorizing  the
execution,  delivery and  consummation  of this  Agreement and the  transactions
contemplated  hereby,  certified  by the  Secretary  or  Assistant  Secretary of
NeoStem as of the Closing Date; and

                  6.3.4.4 a copy of (1) the  certificate  of  incorporation,  as
amended,  of Subco,  certified by the Delaware  Secretary of State and dated not
earlier  than  fifteen  days  prior to the  Closing,  (2) a  certificate  of the
Delaware  Secretary  of State,  dated not earlier than fifteen days prior to the
Closing and confirming  that Subco is in good standing in the State of Delaware,
(3) the by-laws, as amended,  of Subco,  certified by the Secretary or Assistant
Secretary of Subco as of the Closing Date,  and (4) the  resolutions  of Subco's
Board of Directors authorizing the execution,  delivery and consummation of this
Agreement and the transactions  contemplated hereby,  certified by the Secretary
or Assistant Secretary of Subco as of the Closing Date.

                  6.3.4.5.  CBH shall have  received  opinions  of US counsel to
NeoStem and its  Subsidiaries  (the "Legal  Opinion") and tax counsel to NeoStem
and its Subsidiaries (the "Tax Opinion"),  in the form and substance  reasonably
satisfactory to CBH, including without  limitation,  with respect to the Merger,
the  tax-free  status  of  the   reorganization,   and  the  disclosure  in  the
Registration  Statement,  but not with respect to the spin-off or the  preferred
stock.  Such counsel  shall also provide CBH with  appropriate  opinion  letters
prior to the filing of the Registration Statement and/or Joint Proxy Statement.


                                      -60-


            6.3.5  Since  the  date of this  Agreement,  there  shall  not  have
occurred  any act,  event or  omission  having  or  reasonably  likely to have a
NeoStem Material Adverse Effect.

            6.3.6 All reports of NeoStem's  independent  accountants relating to
NeoStem's audited consolidated  financial statements filed with (or incorporated
by reference in any document  filed with) the SEC  subsequent to the date hereof
and  prior  to the  Effective  Time  shall  certify,  without  qualification  or
exception,  that such financial  statements (a) have been prepared in accordance
with generally accepted accounting  principles  consistently  applied during the
periods  involved  and  (b)  fairly  present,  in  all  material  respects,  the
consolidated  financial  position of the  entities  described  therein as of the
dates thereof and the consolidated  results of operations and consolidated  cash
flows of such entities for the periods presented.

            6.3.7  NeoStem's  Board of  Directors  and  stockholders  shall have
adopted an equity  incentive  compensation  plan reasonably  satisfactory to the
Parties.

            6.3.8 NeoStem shall have delivered evidence, satisfactory to CBH, of
the  filing  of the  NeoStem  Certificate  of  Designations  with  the  Delaware
Secretary of State.

            6.3.9 The Escrow Agreement shall have been executed and delivered by
NeoStem  and the  Escrow  Agent  and the  Escrow  Certificates  shall  have been
deposited with the Escrow Agent.

            6.3.10 The  NeoStem  Lock-Up and Voting  Agreement,  dated as of the
date hereof,  among  NeoStem,  Inc. and each director and officer of NeoStem,  a
copy of which is attached  hereto as Exhibit I (the "NeoStem  Lock-Up and Voting
Agreement"), shall be in full force and effect, and each director and officer of
NeoStem shall have performed all of his, her or its obligations under, and shall
not have breached any provision of, the NeoStem Lock-Up and Voting Agreement.

            6.3.11 The Transaction  Expenses.  NeoStem or the Surviving  Company
shall pay for all the reasonable Transaction Expenses.

                                  ARTICLE VII.

                            TERMINATION AND AMENDMENT

      7.1  Termination.  This  Agreement may be terminated and the Merger may be
abandoned at any time prior to the Effective Time  (notwithstanding any approval
of this Agreement by CBH's stockholders and/or NeoStem's stockholders):

            7.1.1 by mutual written consent of NeoStem and CBH;

            7.1.2  by  either  NeoStem  or  CBH if  there  shall  be any  law or
regulation  that, as supported by the written  opinion of outside legal counsel,
makes  consummation  of the Merger  illegal or otherwise  prohibited,  or if any
judgment, injunction, order or decree of a court or other competent Governmental
Authority  enjoining NeoStem or CBH from consummating the Merger shall have been
entered and such judgment,  injunction,  order or decree shall have become final
and nonappealable;


                                      -61-


            7.1.3 by either  NeoStem  or CBH if the  Merger  shall not have been
consummated before the Outside Date (as hereinafter defined), provided, however,
that the right to terminate this Agreement under this Section 7.1.3 shall not be
available to any party whose failure or whose affiliate's failure to perform any
material  covenant or obligation  under this  Agreement has been the cause of or
resulted in the failure of the Merger to occur on or before such date;

            7.1.4  by  either  NeoStem  or  CBH if at the  CBH  Special  Meeting
(including any  adjournment or  postponement  thereof) the requisite vote (under
all  Applicable  Laws) of CBH's  stockholders  to  approve  the  Merger  and the
transactions contemplated hereby shall not have been obtained;

            7.1.5 by either  NeoStem  or CBH if at the  NeoStem  Annual  Meeting
(including any  adjournment or  postponement  thereof) the requisite vote (under
all Applicable  Laws and the rules and  regulations of the Exchange on which the
NeoStem Common Stock is listed or quoted) of NeoStem's stockholders to authorize
the issuance of NeoStem Common Stock in the Merger shall not have been obtained;

            7.1.6 by NeoStem if vFinance, acting in good faith and in accordance
with recognized professional standards consistent with prior practices, declines
to provide NeoStem with opinions, in form and substance satisfactory to NeoStem,
and  based  on  reasonable  and  customary  analyses  as  of  the  date  of  any
Prospectus/Joint Proxy Statement, and an updated Opinion as of the Closing Date,
to the  effect  that  the  Merger  Consideration  is  fair  to  NeoStem  and its
stockholders  from a financial point of view (with such opinions to be delivered
immediately  prior to the filing of the Registration  Statement and the Closing,
respectively);

            7.1.7 by either  NeoStem or CBH if any  representation  or  warranty
made  in  this  Agreement  (including  without  limitation  the  CBH  Disclosure
Statement and the NeoStem Disclosure Statement) for its benefit is untrue in any
material respect (other than  representations and warranties which are qualified
as to  materiality,  which  representations  and  warranties  will  give rise to
termination  if untrue in any respect);  provided  that,  in each case,  (a) the
party seeking to terminate this Agreement is not then in material  breach of any
material representation or warranty contained in this Agreement, (b) such untrue
representation  or warranty cannot be or has not been cured within 30 days after
receipt of written notice of such breach and (c) in the case of CBH,  except for
the representations and warranties  contained in Sections 3.1, 3.2, 3.5 and 3.19
and in the  case of  NeoStem,  except  for the  representations  and  warranties
contained in Sections 4.1, 4.2 and 4.19, such untrue representation and warranty
has, or is reasonably likely to have, a CBH Material Adverse Effect or a NeoStem
Material Adverse Effect, as the case may be and in each case after the Effective
Time and after giving effect to consummation of the transactions contemplated by
this Agreement;

            7.1.8  by  either  NeoStem  or CBH if the  other  party  shall  have
defaulted in the  performance of any material  covenant or agreement  under this
Agreement;  provided that, in each case, (a) the party seeking to terminate this
Agreement has complied with its covenants and agreements under this Agreement in
all material  respects and (b) such failure to comply  cannot be or has not been
cured within 30 days after receipt of written notice of such default;


                                      -62-


            7.1.9 by NeoStem if any authorization,  consent,  waiver or approval
required for the  consummation  of the  transactions  contemplated  hereby shall
require  the  divestiture  or  cessation  of  any  of the  present  business  or
operations  conducted by NeoStem or its  Subsidiaries or CBH or its Subsidiaries
or shall impose any other material condition or requirement,  which divestiture,
cessation,  condition or  requirement,  in the reasonable  judgment of NeoStem's
Board of Directors (or a committee thereof),  would be reasonably likely to have
a NeoStem  Material  Adverse  Effect after the  Effective  Time giving effect to
consummation of the transactions contemplated by this Agreement;

            7.1.10  by  NeoStem,  in  the  event  that  the  conditions  to  its
obligations  set forth in  Article VI have not been  satisfied  or waived by the
date set for the Closing or in the event that such conditions cannot possibly be
satisfied  prior to the  Outside  Date,  provided  that  NeoStem  is not then in
material  breach of any  material  representation,  warranty,  covenant or other
agreement contained in this Agreement;

            7.1.11 by CBH, in the event that the  conditions to its  obligations
set forth in  Article VI have not been  satisfied  or waived by the date set for
the Closing or in the event that such  conditions  cannot  possibly be satisfied
prior to the Outside Date,  provided that CBH is not then in material  breach of
any material representation,  warranty, covenant or other agreement contained in
this Agreement; or

            7.1.12 by NeoStem,  upon  election by its Board of  Directors  (or a
committee thereof),  in the event that the Dissenting Shares represent more than
five (5%) of the  shares of CBH  Common  Stock or CBH  Preferred  Stock  held by
holders thereof who are entitled to vote on the Merger.

            7.1.13 by NeoStem, if the Spin-Off has not been fully consummated by
CBH prior to the Outside  Date.  For  purposes of this  Agreement,  the "Outside
Date" shall mean March 1, 2009.

      7.2 Effect of Termination.

            7.2.1 In the event of the termination of this Agreement  pursuant to
Section  7.1,  this  Agreement,  except  for  any  provisions  relating  to  the
confidentiality  obligations  of the  parties  hereto  to  each  other  and  the
provisions of this Section 7.2 and Section  8.12,  shall become void and have no
effect,  without  any  liability  on the  part of any  party  or its  directors,
officers or stockholders. Notwithstanding the foregoing, nothing in this Section
7.2 shall relieve any party to this Agreement of liability for a material breach
of any material provision of this Agreement.

      7.3  Amendment.  This Agreement may be amended by the parties  hereto,  by
action  taken  or  authorized  by  their  respective  Boards  of  Directors  (or
committees  thereof),  at any time before or after adoption of this Agreement by
CBH's  stockholders,  but after any such  approval,  no amendment  shall be made
which by law requires further  approval or  authorization by CBH's  stockholders
without such further approval or authorization.  Notwithstanding  the foregoing,
this  Agreement may not be amended  except by an instrument in writing signed on
behalf of each of the parties hereto.


                                      -63-



      7.4 Extension;  Waiver.  At any time prior to the Effective Time,  NeoStem
(with  respect to CBH and CBC) and CBH (with  respect  to NeoStem  and Subco) by
action taken or authorized by their respective Boards of Directors (or committee
thereof),  may,  to the  extent  legally  allowed,  (a)  extend the time for the
performance of any of the obligations or other acts of such party, (b) waive any
inaccuracies in the  representations  and warranties  contained herein or in any
document  delivered  pursuant  hereto and (c) waive  compliance  with any of the
agreements or conditions  contained herein. Any agreement on the part of a party
hereto to any such  extension  or waiver  shall be valid  only if set forth in a
written instrument signed on behalf of such party.

                                  ARTICLE VIII.

                                  MISCELLANEOUS

      8.1 No Survival of Representations and Warranties. The representations and
warranties  made herein by NeoStem and CBH shall not survive the Effective  Time
and the  representations  and  warranties.  This Section 8.1 shall not limit any
covenant or  agreement  of the parties  hereto  which by its terms  contemplates
performance after the Effective Time or after the termination of this Agreement.

      8.2  Notices.  All notices or other  communications  required or permitted
hereunder shall be in writing and shall be delivered  personally,  by facsimile,
by overnight  courier or sent by certified or registered mail,  postage prepaid,
and shall be deemed given when so delivered  personally,  or when so received by
facsimile  or  courier,  or if  mailed,  three  calendar  days after the date of
mailing,  as follows (or at such other address for a party as shall be specified
by like notice):

            8.2.1 if to NeoStem or Subco:

                       NeoStem, Inc.
                       420 Lexington Avenue, Suite 450
                       New York, New York  10170
                       Attention:  Catherine Vaczy
                       Telecopy: (646) 514-7787

                       with a copy (which shall not constitute notice) to:

                       Lowenstein, Sandler PC
                       65 Livingston Avenue
                       Roseland, New Jersey 07068
                       Attention:  Alan Wovsaniker, Esq.
                       Telecopy No.: (973) 597-2565


                                      -64-


            8.2.2 if to CBH or CBC:

                      China Biopharmaceuticals, Inc.
                      No. 859, Pan Xu Road
                      Suzhou, Jiangsu Province, China, 215000
                      Attention: Chris Mao
                      Telecopy: _______________

                      with a copy (which shall not constitute notice) to:

                      Troutman Sanders LLP
                      The Chrysler Building
                      405 Lexington Avenue
                      New York, New York  10174
                      Attention:  Howard H. Jiang, Esq.
                      Telecopy:  (212) 704-6288

      8.3 Interpretation.

            8.3.1 When a reference  is made in this  Agreement  to an Article or
Section,  such  reference  shall be to an Article  or Section of this  Agreement
unless otherwise indicated.  The headings and the table of contents contained in
this  Agreement are for reference  purposes only and shall not affect in any way
the meaning or interpretation of this Agreement.

            8.3.2 For purposes of this  Agreement,  "knowledge" of a party shall
mean  the  actual  knowledge  of all  officers  of such  party  with a title  of
executive vice president or higher.

      8.4  Counterparts.  This Agreement may be executed in counterparts,  which
together shall  constitute one and the same  Agreement.  The parties may execute
more than one copy of the Agreement, each of which shall constitute an original.

      8.5 Entire  Agreement.  This  Agreement  (including  the documents and the
instruments  referred  to  herein)  and any and all  confidentiality  agreements
previously  entered  into  between  NeoStem  and CBH or any  Subsidiary  thereof
(collectively, the "Confidentiality Agreements") constitute the entire agreement
among the  parties  and  supersede  all  prior  agreements  and  understandings,
agreements or  representations  by or among the parties,  written and oral, with
respect to the subject matter hereof and thereof.

      8.6  Third-Party  Beneficiaries.  Nothing  in this  Agreement,  express or
implied,   is  intended  or  shall  be  construed  to  create  any   third-party
beneficiaries.


                                      -65-


      8.7 Governing Law. Except to the extent that the laws of the  jurisdiction
of organization of any party hereto, or any other jurisdiction,  are mandatorily
applicable to the Merger or to matters  arising under or in connection with this
Agreement,  this  Agreement  shall  be  governed  by the  laws of the  State  of
Delaware.  All  actions  and  proceedings  arising  out of or  relating  to this
Agreement  shall be heard and  determined  exclusively  in any state or  federal
court sitting in the State of Delaware.

      8.8 Consent to Jurisdiction; Venue.

            8.8.1  Each  of  the  parties  hereto  irrevocably  submits  to  the
exclusive  jurisdiction  of the state courts of Delaware  and the United  States
District  Court for the District of  Delaware,  for the purpose of any action or
proceeding  arising out of or relating to this Agreement and each of the parties
hereto  irrevocably  agrees  that  all  claims  in  respect  to such  action  or
proceeding  shall be heard and  determined  exclusively in any Delaware state or
federal  court.  Each of the parties  hereto agrees that a final judgment in any
action  or  proceeding  shall  be  conclusive  and  may  be  enforced  in  other
jurisdictions by suit on the judgment or in any other manner provided by law.

            8.8.2 Each of the parties hereto irrevocably consents to the service
of any  summons  and  complaint  and any other  process  in any other  action or
proceeding  relating to the Merger, on behalf of itself or its property,  by the
delivery of copies of such process to such party in the same manner as notice is
to be provided pursuant to Section 8.3. Nothing in this Section 8.9 shall affect
the  right of any party  hereto  to serve  legal  process  in any  other  manner
permitted by law.

      8.9 Specific Performance.  The transactions contemplated by this Agreement
are unique.  Accordingly,  each of the parties  acknowledges and agrees that, in
addition to all other remedies to which it may be entitled,  each of the parties
hereto is entitled to a decree of specific  performance,  provided such party is
not in material default hereunder.

      8.10 Assignment.  Neither this Agreement nor any of the rights,  interests
or obligations hereunder shall be assigned by any of the parties hereto (whether
by operation of law or otherwise) without the prior written consent of the other
parties.  Subject to the preceding  sentence,  this  Agreement  shall be binding
upon,  inure to the  benefit  of and be  enforceable  by the  parties  and their
respective successors and assigns.

      8.11  Expenses.  Subject to the  provisions  of Section 8.2, all costs and
expenses  incurred  in  connection  with  this  Agreement  and the  transactions
contemplated  hereby shall be paid by the party incurring such expenses,  except
that those expenses incurred in connection with filing, printing and mailing the
Registration  Statement  and the  Prospectus/Joint  Proxy  Statement  (including
filing  fees  related  thereto  but  excluding  legal  and  accounting  fees and
expenses) and the fees and  disbursements of any Third Party Firm will be shared
equally by NeoStem and CBH.


                                      -66-


      8.12  Severability.  The invalidity of any portion hereof shall not affect
the validity,  force or effect of the remaining  portions hereof.  If it is ever
held that any restriction  hereunder is too broad to permit  enforcement of such
restriction to its fullest  extent,  such  restriction  shall be enforced to the
maximum extent permitted by law.

      8.13 No Strict  Construction.  Each Party acknowledges that this Agreement
has been  prepared  jointly by the  parties  hereto,  and shall not be  strictly
construed against any Party.

      8.14 Language  Translations.  Each Party  acknowledges that this Agreement
has been  prepared  in  English.  In the event of a conflict  between  different
translations of these terms, the English translation will govern.

      8.15  Disbursement of the Escrow Shares.  For a period of no more than six
(6)  months  after the  Effective  Time,  in case the CBH  Payable  Obligations,
excluding  the  Transaction  Expenses,  exceed a total of $450,000,  such excess
shall be paid out of the Escrow  Shares  (valued at one dollar per share) with a
notice provided according to the terms of the Escrow Agreement. CBC shall not be
responsible for any payable obligations in excess beyond $450,000 and the Escrow
Shares.

                  [Remainder of Page Intentionally Left Blank]


                                      -67-


      IN WITNESS WHEREOF, NeoStem, Subco, CBH and CBC have signed this Agreement
as of the date first written above.

                                   NEOSTEM, INC.

                                   By: /s/ Robin L. Smith
                                       --------------------------
                                   Name: Robin L. Smith
                                   Title: Chief Executive Officer


                                   CBH ACQUISITION LLC

                                   By: /s/ Robin L. Smith
                                       --------------------------
                                   Name: Robin L. Smith
                                   Title: Chief Executive Officer


                                   CHINA BIOPHARMACEUTICALS
                                   HOLDINGS, INC.

                                   By: /s/ Chris Peng Mao
                                       --------------------------
                                   Name: Chris Peng Mao
                                   Title: Chief Executive Officer


                                   CHINA BIOPHARMACEUTICALS
                                   CORP.

                                   By: /s/ Chris Peng Mao
                                       --------------------------
                                   Name: Chris Peng Mao
                                   Title: Chief Executive Officer


                [Signature Page to Agreement and Plan of Merger]


                                      -68-