UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                 SEC FILE NUMBER
                                    033-20897
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                                  CUSIP NUMBER
                                   423287 309
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                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING

(Check one)   Form 10-K    Form 10-KSB    Form 20-F   X Form 10-Q     Form N-SAR
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                       For Period Ended:  March 31, 2003
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                         Transition Report on Form 10-K
                         Transition Report on Form 20-F
                         Transition Report on Form 11-K
                         Transition Report on Form 10-Q
                         Transition Report on Form N-SAR
          For the Transition Period Ended: ____________________________

     Nothing in this form shall be  construed to imply that the  Commission  has
verified any information herein.

     If the  notification  related  to a portion of the  filing  checked  above,
identify the Item(s) to which the notification relates:

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PART I -- REGISTRANT INFORMATION

HELIX BIOMEDIX, INC.
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Full Name of Registrant


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Former Name if Applicable

22122 20TH Ave. SE
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Address of Principal Executive Office (Street and Number)

Bothell, WA  98021
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City, State and Zip Code

PART II -- RULES 12b-25(b) AND (c)

If the subject report could not be filed without  unreasonable effort or expense
and the  registrant  seeks  relief  pursuant to Rule 12 b-25(b),  the  following
should be completed. (Check box if appropriate) [X]

(a)      The  reason  described  in  reasonable  detail in Part III of this form
         could not be completed without unreasonable effort or expense;
(b)      The subject annual report,  semi-annual  report,  transition  report on
         Form 10-K, Form 20-F, Form 11-K or Form NSAR, or portion thereof,  will
         be filed on or before the fifteenth day  following the  prescribed  due
         date;  or the subject  quarterly  report or  transition  report on Form
         10-Q, or portion  thereof will be filed on or before the fifth calendar
         day following the prescribed due date; and
(c)      The accountant's  statement or other exhibit required by Rule 12b-25(c)
         has been attached if applicable.

PART III -- NARRATIVE

State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, N-SAR, or the
transition  report or portion thereof,  could not be filed within the prescribed
time period.

The  registrant's  Form 10-QSB cannot be filed without  unreasonable  effort and
expense to  complete  the  document  and obtain the  appropriate  approvals  and
signatures.

PART IV -- OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
     notification:

         Kerry D. Palmer                425                         402-8400
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             (Name)                  (Area Code)              (Telephone Number)

(2)  Have all other periodic  reports  required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months or for such shorter  period that the
     registrant was required to file such report(s) been filed? If answer is no,
     identify report(s)  [X] Yes    [] No

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(3)  Is it anticipated that any significant change in results of operations from
     the corresponding  period for the last fiscal year will be reflected by the
     earnings  statements  to be  included  in the  subject  report  or  portion
     thereof?  [] Yes  [X]No
     If so, attach an explanation of the anticipated  change,  both  narratively
     and quantitatively, and, if appropriate, state the reasons why a reasonable
     estimate of the results cannot be made.

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                              HELIX BIOMEDIX, INC.
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                  (Name of Registrant as Specified in Charter)

has  caused  this  notification  to be signed on its  behalf by the  undersigned
hereunto duly authorized.

     Date May 15, 2003                   By    /s/ Kerry D. Palmer
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                                               Kerry D. Palmer, Chief Financial
                                               Officer