Exhibit 4.3


THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE "1933 ACT"), OR UNDER THE PROVISIONS OF ANY APPLICABLE STATE SECURITIES
LAWS, BUT HAS BEEN ACQUIRED BY THE REGISTERED HOLDER HEREOF FOR PURPOSES OF
INVESTMENT AND IN RELIANCE ON STATUTORY EXEMPTIONS UNDER THE 1933 ACT, AND UNDER
ANY APPLICABLE STATE SECURITIES LAWS. THIS NOTE MAY NOT BE SOLD, PLEDGED,
TRANSFERRED OR ASSIGNED EXCEPT IN A TRANSACTION WHICH IS EXEMPT UNDER PROVISIONS
OF THE 1933 ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN
EFFECTIVE REGISTRATION STATEMENT; AND IN THE CASE OF AN EXEMPTION, ONLY IF THE
COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH
TRANSACTION DOES NOT REQUIRE REGISTRATION OF THIS NOTE.

                        IN VIVO MEDICAL DIAGNOSTICS, INC.


                  December 22, 2004 North Inverness, Scotland

$250,000.00

                               8% PROMISSORY NOTE

     Pursuant to the terms of this 8% Promissory Note (the "Note"), In Vivo
Medical Diagnostics, Inc., a Colorado corporation (the "Company"), for value
received, hereby promises to pay to Nite Capital, L.P. or its registered assigns
(the "Holder") on the earlier of (i) June 22, 2005 or (ii) the date subsequent
to the date of this Note that the Company enters into any financing or
financings of any type aggregating $1,500,000 or more (the "Maturity Date"), at
the principal offices of the Company, the principal sum Two Hundred Fifty
Thousand Dollars ($250,000) in such coin or currency of the United States of
America as at the time of payment shall be legal tender for the payment of
public and private debts, and interest on the outstanding principal sum, such
interest to be computed at the rate of eight percent (8%) per annum. Principal
and accrued interest shall be payable on the Maturity Date in like coin or
currency to the Holder hereof at the office of the Company as hereinafter set
forth, provided that any payment otherwise due on a Saturday, Sunday or legal
Bank holiday may be paid on the following business day. In the event that for
any reason whatsoever any interest or other consideration payable with respect
to this Note shall be deemed to be usurious by a court of competent jurisdiction
under the laws of the State of New York or the laws of any other state governing
the repayment hereof, then so much of such interest or other consideration as
shall be deemed to be usurious shall be held by the holder as security for the
repayment of the principal amount hereof and shall otherwise be waived.

     1. Transfers of Note to Comply with the 1933 Act
     ------------------------------------------------

     The Holder agrees that this Note may not be sold, transferred, pledged,
hypothecated or otherwise disposed of except as follows: (1) to a person whom
the Note may legally be transferred without registration and without delivery of
a current prospectus under the 1933 Act with respect thereto and then only
against receipt of an agreement of such person to comply with the provisions of
this Section 1 with respect to any resale or other disposition of the Note; or
(2) to any person upon delivery of a prospectus then meeting the requirements of
the 1933 Act relating to such securities and the offering thereof for such sale
or disposition, and thereafter to all successive assignees.



     2. Prepayment; Conversion
     -------------------------

     (a)  The principal amount of this Note may be prepaid by the Company, in
          whole or in part without premium or penalty, at any time. In the event
          the Company intends to prepay any or all of the outstanding principal
          or interest on this Note, the Company must provide written notice to
          the Holder at least 10 days prior to the proposed prepayment date
          ("Prepayment Date").

     (b)  In the event that the Company, subsequent to the date of this Note,
          enters into any financing or financings of any type aggregating
          $1,000,000, then and in such event the Company shall be required to
          make a partial prepayment (a "Partial Prepayment") of $175,000 of the
          principal amount of this Note and the pro rata share of interest
          accrued to date on such portion the Note. In addition, in the event
          that the Company, subsequent to the date of this Note, enters into any
          financing or financings of any type aggregating more than $1,000,000
          but less than $1,500,000, then and in such event the amount of the
          Partial Prepayment shall be increased on a pro-rata basis (up to the
          full principal amount of this Note and the pro rata share of interest
          accrued to date on the Note in the case of a financing totaling at
          least $1,500,000). The Company shall be required to notify the Holder
          in writing of any financing which results in the Company being
          required to prepay the Note, in whole or in part, prior to June 22,
          2005, and to make such payment within three business days after the
          Company receives the proceeds of such financing.

     (c)  Upon any prepayment of the entire principal amount of this Note, all
          accrued, but unpaid interest shall be paid to the Holder on the date
          of prepayment. In the event the Company prepays any portion of the
          principal or interest on this Note, the Holder shall deliver this Note
          to the Company and the Company shall issue a new Note to the Holder
          evidencing the reduction of principal or interest.

     3. Covenants of Company
     -----------------------

     The Company covenants and agrees that, so long as any principal of, or
interest on, this Note shall remain unpaid, unless the Holder shall otherwise
consent in writing, it will comply with the following terms:

     (a)  Reporting Requirements. The Company will furnish to the Holder:

          (i)  as soon as possible, and in any event within five (5) days after
               obtaining knowledge of the occurrence of (A) an "Event of
               Default," as hereinafter defined, (B) an event which, with the
               giving of notice or the lapse of time or both, would constitute
               an Event of Default, or (C) a material adverse change in the
               condition or operations, financial or otherwise, of the Company,
               taken as whole, the written statement of the Chief Executive
               Officer or the Chief Financial Officer of the Company, setting
               forth the details of such Event of Default, event or material
               adverse change and the action which the Company proposes to take
               with respect thereto;

                                        2



          (ii) promptly after the sending or filing thereof, copies of all
               financial statements, reports, certificates of its Chief
               Executive Officer, Chief Financial Officer or accountants and
               other information which the Company or any subsidiary sends to
               any holders (other than the Notes) of its securities;

          (iii) promptly after the commencement thereof, notice of each action,
               suit or proceeding before any court or other governmental
               authority or other regulatory body or any arbitrator as to which
               there is a reasonable possibility of a determination that would
               (A) materially impact the ability of the Company or any
               subsidiary to conduct its business, (B) materially and adversely
               affect the business, operations or financial condition of the
               Company taken as a whole, or (C) impair the validity or
               enforceability of the Notes or the ability of the Company to
               perform its obligations under the Notes;

          (iv) in accordance with the provisions of Section 2(b) of this Note,
               of any subsequent financing which will trigger a mandatory
               prepayment obligation of the Company. . (b) Compliance with Laws.
               The Company will comply, in all material respects with all
               applicable laws, rules, regulations and orders, except to the
               extent that noncompliance would not have a material adverse
               effect upon the business, operations or financial condition of
               the Company taken as a whole.

     (c)  Preservation of Existence. The Company will maintain and preserve, and
          cause each subsidiary, if any, to maintain and preserve, its
          existence, and become or remain duly qualified and in good standing in
          each jurisdiction in which the failure to be so qualified would have a
          material adverse effect on the business, operations or financial
          condition of the Company, taken as a whole.

     (d)  Maintenance of Properties. The Company will maintain and preserve, all
          of its properties which are necessary in the proper conduct of its
          business in good working order and condition, ordinary wear and tear
          excepted, and comply, at all times with the provisions of all leases
          to which it is a party as lessee or under which it occupies property,
          so as to prevent any forfeiture or material loss thereof or
          thereunder.

     (e)  Maintenance of Insurance. The Company will maintain, with responsible
          and reputable insurers, insurance with respect to its properties and
          business, in such amounts and covering such risks, as is carried
          generally in accordance with sound business practice by companies in
          similar businesses in the same localities in which the Company is
          situated.

     (f)  Keeping of Records and Books of Account. The Company will keep
          adequate records and books of account, with complete entries made in
          accordance with generally accepted accounting principles, reflecting
          all of its financial and other business transactions.

                                        3


     (g)  Compliance with the Securities Exchange Act of 1934. The Company shall
          comply in all respects with the requirements of the Securities
          Exchange Act of 1934, including the filing of all reports due
          thereunder.

     (h)  Reservation of Common Stock. The Company further covenants and agrees
          that the Company will use its best efforts to at all times have
          authorized and reserved, free from preemptive rights, a sufficient
          number of shares of its common stock to provide for the conversion of
          this Note in full. As of the date hereof, the Company does not have
          any shares reserved or available for reservation for the conversion of
          this Note.

     4. Events of Default and Remedies
     ---------------------------------

     (a)  Any one or more of the following events which shall have occurred and
          be continuing shall constitute an event of default ("Event of
          Default"):

          (i)  Default in the payment of interest upon this Note, as and when
               the same shall become due; or

          (ii) Default in the payment of the principal of this Note, as and when
               the same shall become due; or

          (iii) The Company shall fail to perform or observe any affirmative
               covenant contained in this Note or the subscription agreement
               executed by the Company and the Holder as of the date hereof and
               such Default, if capable of being remedied, shall not have been
               remedied ten (10) days after written notice thereof shall have
               been given by the Holder to the Company; or

          (iv) The Company or any subsidiary (A) shall institute any proceeding
               or voluntary case seeking to adjudicate it bankrupt or insolvent,
               or seeking dissolution, liquidation, winding up, reorganization,
               arrangement, adjustment, protection, relief or composition of it
               or its debts under any law relating to bankruptcy, insolvency or
               reorganization or relief of debtors, or seeking the entry of any
               order for relief or the appointment of a receiver, trustee,
               custodian or other similar official for such the Company or any
               subsidiary or for any substantial part of its property, or shall
               consent to the commencement against it of such a proceeding or
               case, or shall file an answer in any such case or proceeding
               commenced against it consenting to or acquiescing in the
               commencement of such case or proceeding, or shall consent to or
               acquiesce in the appointment of such a receiver, trustee,
               custodian or similar official; (B) shall be unable to pay its
               debts as such debts become due, or shall admit in writing its
               inability to apply its debts generally; (C) shall make a general
               assignment for the benefit of creditors; or (D) shall take any
               action to authorize or effect any of the actions set forth above
               in this subsection 3 (iv); or

                                        4


          (v)  Any proceeding shall be instituted against the Company seeking to
               adjudicate it a bankrupt or insolvent, or seeking dissolution,
               liquidation, winding up, reorganization, arrangement, adjustment,
               protection, relief of debtors, or seeking the entry of an order
               for relief or the appointment of a receiver, trustee, custodian
               or other similar official for the Company or for any substantial
               part of its property, and either such proceeding shall not have
               been dismissed or shall not have been stayed for a period of
               sixty (60) days or any of the actions sought in such proceeding
               (including, without limitation, the entry of any order for relief
               against it or the appointment of a receiver, trustee, custodian
               or other similar official for it or for any substantial part of
               its property) shall occur; or

          (vi) One or more final judgments or orders for the payment of money in
               excess of $100,000 in the aggregate shall be rendered against the
               Company, and either (A) enforcement proceedings shall have been
               commenced by any creditor upon any such judgment or order, or (B)
               there shall be any period of thirty (30) days during which
               enforcement of any such judgment or order shall not be
               discharged, stayed or fully satisfied; or

     (b)  If an Event of Default described above has occurred, then the Holder
          may either

          (i)  without further notice to the Company, declare the principal
               amount of this Note at the time outstanding, together with
               accrued unpaid interest thereon, and all other amounts payable
               under this Note to be forthwith due and payable, whereupon such
               principal, interest and all such amounts shall become and be
               forthwith due and payable; or

          (ii) in the case of an event of default described in Section 4(a)(i)
               or (ii) hereof which continues for at least three business days,
               elect to convert all of the principal and interest owing on this
               Note into shares of the Company's common stock, subject to the
               restrictions contained herein. The conversion price per share
               shall be fifty percent (50%) of the average of the three lowest
               closing prices for the Common Stock on the NASD OTC Bulletin
               Board (or such other principal market or exchange where the
               Common Stock is listed or traded at the time of conversion) for
               the ten days immediately preceding the Maturity Date. Such
               election to convert shall be evidenced by completion of the
               conversion notice attached hereto and delivery of such notice to
               the Company within five business days of (i) the Holder's receipt
               of a notice from the Company pursuant to Section 2 that a
               prepayment is due, or (ii) the Maturity Date. The Holder's right
               to convert the obligations due under this Note to common stock
               shall supercede the Company's right to repay such obligations in
               cash, subject to the restrictions contained herein.

     (c)  The Company covenants that in case the principal of, and accrued
          interest on, the Note becomes due and payable by declaration or
          otherwise, then the Company will pay in cash, or in Common Stock of
          the Company if required under this Agreement, to the Holder of this
          Note, the whole amount that then shall have become due and payable on
          this Note for principal or interest, as the case may be, and in
          addition thereto, such further amount as shall be sufficient to cover
          the costs and expenses of collection, including reasonable fees and
          disbursements of the Holder's legal counsel if no conversion of the
          Note to Common Stock of the Company has been made. In case the Company
          shall fail forthwith to pay such amount, the Holder may commence an
          action or proceeding at law or in equity for the collection of the
          sums so due and unpaid, and may prosecute any such action or
          proceeding to judgment or final decree against Company or other
          obligor upon this Note, wherever situated, the monies adjudicated or
          decreed to be payable.

                                        5


     5. Miscellaneous
     ----------------

     (a)  This Note has been issued by the Company pursuant to authorization of
          the Board of Directors of the Company.

     (b)  The Company may consider and treat the entity in whose name this Note
          shall be registered as the absolute owner thereof for all purposes
          whatsoever (whether or not this Note shall be overdue) and the Company
          shall not be affected by any notice to the contrary. Subject to the
          limitations herein stated, the registered owner of this Note shall
          have the right to transfer this Note by assignment, and the transferee
          thereof shall, upon his registration as owner of this Note, become
          vested with all the powers and rights of the transferor. Registration
          of any new owners shall take place upon presentation of this Note to
          the Company at its principal offices, together with a duly
          authenticated assignment. In case of transfer by operation of law, the
          transferee agrees to notify the Company of such transfer and of his
          address, and to submit appropriate evidence regarding the transfer so
          that this Note may be registered in the name of the transferee. This
          Note is transferable only on the books of the Company by the holder
          hereof, in person or by attorney, on the surrender hereof, duly
          endorsed. Communications sent to any registered owner shall be
          effective as against all holders or transferees of the Note not
          registered at the time of sending the communication.

     (c)  Payments of principal and interest shall be made as specified above to
          the registered owner of this Note. No interest shall be due on this
          Note for such period of time that may elapse between the maturity of
          this Note and its presentation for payment.

     (d)  The Holder shall not, by virtue, hereof, be entitled to any rights of
          a shareholder in the Company, whether at law or in equity, and the
          rights of the Holder are limited to those expressed in this Note.

     (e)  Upon receipt by the Company of evidence reasonably satisfactory to it
          of the loss, theft, destruction or mutilation of this Note, and (in
          the case of loss, theft or destruction) of reasonably satisfactory
          indemnification, and upon surrender and cancellation of this Note, if
          mutilated, the Company shall execute and deliver a new Note of like
          tenor and date.

     (f)  This Note shall be construed and enforced in accordance with the laws
          of the State of New York. The Company and the Holder hereby consent to
          the jurisdiction of the Courts of the State of New York and the United
          States District Courts situated therein in connection with any action
          concerning the provisions of this Note instituted by the Holder
          against the Company.

     (g)  All communications under this Agreement shall be in writing and shall
          be mailed by first class mail, postage prepaid, or telegraphed or
          telexed with confirmation of receipt or delivered by hand or by
          overnight delivery service,

                                        6


          If to the Company, at:

                            In Vivo Diagnostics, Inc.
                            The Green House
                            Beechwood Business Park,
                            North Inverness, Scotland IV2 3BL


          or at such other address as it may have furnished in writing to the
          Holder, or

          If to the Holder, to the address of such Holder as it appears in the
          stock ledger of the Company.

          Any notice so addressed, when mailed by registered or certified mail
          shall be deemed to be given three days after so mailed, when
          telegraphed or telexed shall be deemed to be given when transmitted,
          or when delivered by hand or overnight shall be deemed to be given
          when delivered.

     IN WITNESS WHEREOF, In Vivo Medical Diagnostics, Inc.caused this Note to be
signed in its name by its Chief Executive Officer.

                                IN VIVO MEDICAL DIAGNOSTICS, INC


                                 By:
                                    -----------------------------------------

                                        7



                              NOTICE OF CONVERSION

     (To be executed by the Registered Holder in order to convert the Note)


     The undersigned hereby elects to convert all of the principal and interest
due on the Note issued by In Vivo Medical Diagnostics, Inc., into Shares of
Common Stock according to the conditions set forth in Section 4(b)(ii) of such
Note, as of the date written below. The undersigned further affirms that as of
the date hereof, the representations and warranties made by the undersigned in
the subscription agreement of even date with the promissory note being
converted, are true and correct as if such representations and warranties were
made as of the date hereof.



Date of Conversion:_____________________________________________________________


Conversion Price:  $____________per share


Shares To Be Delivered:_________________________________________________________


Signature:______________________________________________________________________


Print Name:_____________________________________________________________________


Address:________________________________________________________________________

        ________________________________________________________________________


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