1 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 February 16, 2001 (Date of earliest event reported) HYSEQ, INC. (Exact name of Registrant as specified in its charter) Nevada 0-22873 36-3855489 (State of (Commission File No.) (IRS Employer Incorporation) Identification No.) 670 Almanor Avenue Sunnyvale, California 94085 (Address of principal executive offices, including zip code) 408-524-8100 (Registrant's telephone number, including area code) 2 Item 5. Other Events. On February 16, 2001, Hyseq announced the resignation of Mark Gitter as Chief Financial Officer. For further information, see the press release of Hyseq, Inc., dated February 16, 2001, attached hereto as Exhibit 99.1. Item 7. Financial Statements and Exhibits. (c) Exhibits 99.1 Press Release, dated February 16, 2001. SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. HYSEQ, INC. /s/ Ted W. Love -------------------------------------------- Name: Ted W. Love Title: President and Chief Operating Officer Date: February 20, 2001 3 EXHIBIT INDEX Exhibit No. Description of Exhibit - ----------- ---------------------- 99.1 Press Release, dated February 16, 2001.