1 As filed with the Securities and Exchange Commission on September 20, 2001 Registration No. 333- ================================================================================ SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 -------------------- FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 -------------------- CALIPER TECHNOLOGIES CORP. (Exact name of registrant as specified in its charter) DELAWARE 33-0675808 (State of Incorporation) (I.R.S. Employer Identification No.) -------------------- 605 FAIRCHILD DRIVE MOUNTAIN VIEW, CA 94043-2234 (Address of principal executive offices including zip code) -------------------- 1999 EQUITY INCENTIVE PLAN 1999 EMPLOYEE STOCK PURCHASE PLAN 1999 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN (Full title of the plans) JAMES L. KNIGHTON CHIEF FINANCIAL OFFICER CALIPER TECHNOLOGIES CORP. 605 FAIRCHILD DRIVE MOUNTAIN VIEW, CA 94043-2234 (650) 623-0700 (Name, address, including zip code, and telephone number, including area code, of agent for service) -------------------- COPIES TO: ROBERT L. JONES, ESQ. BRETT D. WHITE, ESQ. COOLEY GODWARD LLP FIVE PALO ALTO SQUARE 3000 EL CAMINO REAL PALO ALTO, CALIFORNIA 94306 (650) 843-5000 -------------------- 2 CALCULATION OF REGISTRATION FEE =============================================================================================================================== PROPOSED MAXIMUM PROPOSED MAXIMUM TITLE OF SECURITIES AMOUNT TO BE REGISTERED OFFERING AGGREGATE AMOUNT OF TO BE REGISTERED (1) PRICE PER SHARE (2) OFFERING PRICE (2) REGISTRATION FEE --------------------------- ------------------------ ------------------------ ------------------------ ------------------------ Common Stock (par (see Notes to Calculation value $0.001) 1,555,436 of Registration Fee) $16,798,173.38 $4,199.54 =============================================================================================================================== (1) 1,350,058 shares to be registered pursuant to the 1999 Equity Incentive Plan, 128,361 shares to be registered pursuant to the 1999 Employee Stock Purchase Plan and 77,017 shares to be registered pursuant to the 1999 Non-Employee Directors' Stock Option Plan. This Registration Statement shall cover any additional shares of Common Stock which become issuable under the plans set forth herein by reason of any stock dividend, stock split, recapitalization or any other similar transaction without receipt of consideration which results in an increase in the number of shares of the Registrant's outstanding Common Stock. (2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rule 457(h). The price per share and aggregate offering price of the shares to be offered under the these plans are based upon (a) the weighted average exercise price for shares issuable pursuant to outstanding options granted under the 1999 Equity Incentive Plan and (b) the average of the high and low prices of the Registrant's Common Stock on September 18, 2001 as reported on the Nasdaq National Market (pursuant to Rule 457(c) under the Act) for shares reserved for future issuance under (i) the 1999 Equity Incentive Plan, (ii) the 1999 Employee Stock Purchase Plan and (iii) the 1999 Non-Employee Directors' Stock Option Plan. The registration fee is calculated as follows: PLAN NUMBER OF SHARES OFFERING PRICE PER SHARE AGGREGATE OFFERING PRICE --------------------------------------- ------------------------ ------------------------- ------------------------ Shares issuable pursuant to 27,718 $15.19 $421,036.42 outstanding options under the 1999 Equity Incentive Plan Shares reserved for future issuance 1,322,340 $10.72 $14,175,484.80 under the 1999 Equity Incentive Plan Shares reserved for future issuance 128,361 $10.72 $1,376,029.92 under the 1999 Employee Stock Purchase Plan Shares reserved for future issuance 77,017 $10.72 $825,622.24 under the 1999 Non-Employee Directors' Stock Option Plan ------------------------ ------------------------- ------------------------ TOTAL 1,555,436 $16,798,173.38 3 INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION STATEMENTS ON FORMS S-8 The contents of Registration Statement on Form S-8 (No. 333-95007) filed with the Securities and Exchange Commission on January 20, 2000 are incorporated by reference herein. The contents of Registration Statement on Form S-8 (No. 333-40466) filed with the Securities and Exchange Commission on June 29, 2000 are incorporated by reference herein. EXHIBITS EXHIBIT NUMBER DESCRIPTION 4.1(1) Amended and Restated Certificate of Incorporation of the Registrant. 4.2(2) Amended and Restated Bylaws of the Registrant. 4.3(3) Specimen Stock Certificate. 5.1 Opinion of Cooley Godward LLP. 23.1 Consent of Ernst & Young LLP, independent auditors. 23.2 Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1. 24.1 Power of Attorney. Reference is made to Signature Page. 99.2(4) 1999 Equity Incentive Plan. 99.3(4) 1999 Employee Stock Purchase Plan. 99.4(4) 1999 Non-Employee Directors' Stock Option Plan. (1) Previously filed as Exhibit 3.3 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (2) Previously filed as Exhibit 3.4 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (3) Previously filed as Exhibit 4.2 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (4) Previously filed as the like-numbered Exhibit to the Registration Statement on Form S-8 (No. 333-95007), and incorporated herein by reference. 4 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Mountain View, State of California, September 18, 2001. Caliper Technologies Corp. By: /s/ James L. Knighton ----------------------------------- James L. Knighton Chief Financial Officer POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Daniel L. Kisner, M.D. and James L. Knighton, and each or any one of them, his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof. 5 Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated. SIGNATURE TITLE DATE /s/ Daniel L. Kisner, M.D. President, Chief Executive Officer and September 18, 2001 ----------------------------------- Director (Principal Executive Officer) Daniel L. Kisner, M.D. /s/ James L. Knighton Chief Financial Officer September 18, 2001 ----------------------------------- (Principal Financial Officer) James L. Knighton /s/ Anthony Hendrickson Corporate Controller September 18, 2001 ----------------------------------- (Principal Accounting Officer) Anthony Hendrickson /s/ David V. Milligan, Ph.D. Director September 18, 2001 ----------------------------------- David V. Milligan, Ph.D. /s/ Anthony B. Evnin, Ph.D. Director September 18, 2001 ----------------------------------- Anthony B. Evnin, Ph.D. /s/ Regis P. McKenna Director September 18, 2001 ----------------------------------- Regis P. McKenna /s/ Robert T. Nelsen Director September 18, 2001 ----------------------------------- Robert T. Nelsen 6 EXHIBIT INDEX EXHIBIT NUMBER DESCRIPTION 4.1(1) Amended and Restated Certificate of Incorporation of the Registrant. 4.2(2) Amended and Restated Bylaws of the Registrant. 4.3(3) Specimen Stock Certificate. 5.1 Opinion of Cooley Godward LLP. 23.1 Consent of Ernst & Young LLP, independent auditors. 23.2 Consent of Cooley Godward LLP. Reference is made to Exhibit 5.1. 24.1 Power of Attorney. Reference is made to Signature Page. 99.2(4) 1999 Equity Incentive Plan. 99.3(4) 1999 Employee Stock Purchase Plan. 99.4(4) 1999 Non-Employee Directors' Stock Option Plan. (1) Previously filed as Exhibit 3.3 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (2) Previously filed as Exhibit 3.4 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (3) Previously filed as Exhibit 4.2 to the Registration Statement on Form S-1 (No. 333-88827), as amended, and incorporated herein by reference. (4) Previously filed as the like-numbered Exhibit to the Registration Statement on Form S-8 (No. 333-95007), and incorporated herein by reference.