As filed with the Securities and Exchange Commission on February 11, 2000

                                                    Registration No. 333-_______
- --------------------------------------------------------------------------------


                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                           ---------------------------
                                    FORM S-3

                             REGISTRATION STATEMENT

                                      UNDER

                           THE SECURITIES ACT OF 1933
                           ---------------------------

                           ACCENT COLOR SCIENCES, INC.
             (Exact Name of Registrant as Specified in its Charter)
                           ---------------------------



                                                                               

(State or other Jurisdiction of       (Address, including Zip Code, and Telephone      (I.R.S. Employer
  Incorporation or Organization)      Number, including Area Code, of Registrant's   Identification Number)
                                              Principal Executive Offices)

       CONNECTICUT                            800 Connecticut Boulevard                   06-1380314
                                           East Hartford, Connecticut, 06108
                                                     (860) 610-4000


                           ---------------------------

            (Name, Address, including Zip Code, and Telephone Number,
                   including Area Code, of Agent for Service)

         Charles E. Buchheit                            Copy to:
                                                        --------
President and Chief Executive Officer            Willard F. Pinney, Jr.
     Accent Color Sciences, Inc.        Murtha, Cullina, Richter and Pinney, LLP
      800 Connecticut Boulevard         CityPlace I185 Asylum Street, 29th Floor
   East Hartford, Connecticut 06108         Hartford, Connecticut 06103-3469
            (860) 610-4000                           (860) 240-6000

                           ---------------------------

          Approximate  date of the start of proposed  sale to the  public:  From
time to time after this registration statement becomes effective.

If the only securities  being registered on this Form are being offered pursuant
to dividend or interest reinvestment plans, check the following box. / /

If any of the  securities  being  registered on this Form are to be offered on a
delayed or continuous  basis  pursuant to Rule 415 under the  Securities  Act of
1933, as amended, other than securities offered only in connection with dividend
or interest reinvestment plans, check the following box. /X/

If this form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the  Securities  Act  registration  statement  number of the  earlier  effective
registration statement for the same offering. / /



If this form is a  post-effective  amendment filed pursuant to Rule 462(c) under
the  Securities  Act,  check  the  following  box and  list the  Securities  Act
registration  statement number of the earlier effective  registration  statement
for the same offering. / /

If delivery of the  prospectus is expected to be made pursuant to Rule 434 under
the Securities Act, please check the following box. / /

                         CALCULATION OF REGISTRATION FEE



- ----------------------- ----------------------- ------------------ --------------------- --------------------
 Title of each class         Amount to be       Proposed maximum     Proposed maximum         Amount of
 of securities to be          registered         offering price     aggregate offering    registration fee
      registered                                   per unit(1)            price
- ----------------------- ----------------------- ------------------ --------------------- --------------------
                                                                             
common stock,
no par value per             12,418,750             $.8925            $11,083,734            $2,926.10
    share                    shares (2)
- ----------------------- ----------------------- ------------------ --------------------- --------------------


(1) Estimated in accordance  with Rule 457(c) under the  Securities Act of 1933,
solely  for the  purpose  of  calculating  the  registration  fee based upon the
average  of the  high  and low  sale  prices  reported  on the  Over-the-Counter
Bulletin Board system on February 7, 2000.

(2) Pursuant to Rule 416 of the  Securities  Act, the number of shares of common
stock  to  be  registered  on  this  registration  statement  also  includes  an
indeterminate  number of shares which may become  issuable upon conversion of or
otherwise  with respect to the Series C convertible  preferred  stock to prevent
dilution resulting from stock splits, stock dividends or similar transactions.

The registrant amends this  registration  statement on such date or dates as may
be  necessary  to delay its  effective  date until the  registrant  shall file a
further amendment which  specifically  states that this  registration  statement
shall  thereafter  become  effective  in  accordance  with  Section  8(a) of the
Securities  Act of  1933  or  until  the  registration  statement  shall  become
effective on the date as the  Commission,  acting pursuant to said Section 8(a),
may determine.



The  information  in this  prospectus is not complete and may be changed.  These
securities  may not be sold  until the  registration  statement  filed  with the
Securities and Exchange Commission is effective. This prospectus is not an offer
to sell nor does it seek an offer to but these  securities  in any  jurisdiction
where the offer or sale is not permitted.

                                   PROSPECTUS

                        12,418,750 SHARES OF COMMON STOCK

                           ACCENT COLOR SCIENCES, INC.

                           ---------------------------

          This  prospectus  relates  to the  periodic  sale of up to  12,418,750
shares of common  stock of Accent  Color  Sciences,  Inc.  that are  offered  by
certain  of our  shareholders,  that have been  issued or may be  issuable  upon
conversion  of some or all of the shares of our Series C  Convertible  Preferred
Stock and that are issuable  upon the exercise of certain  warrants that we have
granted.  All proceeds from the sale of common stock under this  prospectus will
go to the selling shareholders listed on page 15 of the prospectus.

          Our common stock is traded on the  Over-the-Counter  Bulletin Board of
the National Association of Securities Dealers, Inc. under the symbol "ACLR". On
February 7, 2000,  the last  reported sale price of our common stock as reported
on the OTC was $.87 per share.

                           ---------------------------

          The shares of common  stock  offered  hereby  involve a high degree of
risk.  You should  purchase  shares only if you can afford a complete  loss. See
"Risk Factors"  beginning on page 2 for a discussion of certain factors that you
should consider before you purchase any shares of our common stock.

          Neither  the  Securities   and  Exchange   Commission  nor  any  state
securities  commission  has  approved  or  disapproved  of these  securities  or
determined if this prospectus is truthful or complete. Any representation to the
contrary is a criminal offense.

            The date of this prospectus is __________________, 2000.



                                TABLE OF CONTENTS

                                                                            PAGE

About Accent Color Sciences, Inc..............................................2
Risk Factors..................................................................2
Forward Looking Statements...................................................13
Where You Can Find More Information..........................................13
Documents We Incorporate By Reference .......................................14
Selling Stockholders ........................................................15
Use of Proceeds..............................................................18
Plan of Distribution ........................................................19
Legal Matters ...............................................................20
Experts .....................................................................21
Index to Exhibits............................................................28



                        ABOUT ACCENT COLOR SCIENCES, INC.

          We design,  manufacture  and sell  innovative,  high-speed,  highlight
color  printing  systems  ("Truecolor  Systems") for  integration  with digital,
high-speed,  monochrome  printers and also sell related  consumables.  Highlight
color  printing  involves  the use of color to  enhance  traditional  monochrome
documents by accenting critical information,  such as a balance due on a billing
statement,  or by printing graphics,  like a company logo. Truecolor Systems are
designed to print highlight color in high-speed,  high-volume  applications at a
low  incremental  cost per page without  diminishing the speed or performance of
the  high-speed,  monochrome  host printer or affecting the end user's  existing
operational  methods.  They are  capable of printing up to 501 pages per minute,
simultaneously  utilizing up to eight different colors, including custom colors,
to print or highlight  fixed or variable  data.  Truecolor  Systems  combine our
proprietary  paper handling  technology  with patented ink jet  technology  from
Spectra,  Inc. Under the agreement with Spectra,  we hold an exclusive  right to
supply products,  which include Spectra ink jet printheads to print color on the
monochrome  output from specified  high-speed  printers from Xerox  Corporation,
International  Business  Machines  Corporation and certain other  manufacturers,
through the year 2002. We are not, however, currently in compliance with certain
volume purchase  requirements  necessary to maintain such  exclusivity.  We also
hold a right to extend the agreement with Spectra for an additional seven years.

          We also sell consumables including standard and custom color wax-based
inks,  as well as spare  parts  used with  Truecolor  Systems.  We  expect  that
consumables will generate recurring revenue that we believe will increase as the
installed base and usage of Truecolor Systems increase.

          Accent Color was  incorporated  under the laws of  Connecticut  in May
1993. Our principal executive offices are located at 800 Connecticut  Boulevard,
East Hartford, Connecticut, 06108. Our telephone number at that address is (860)
610-4000.

                                  RISK FACTORS

          An investment  in Accent Color common stock  involves a high degree of
risk.  You should  carefully  consider  the  following  risk  factors  and other
information in this  prospectus and the documents we incorporate by reference in
evaluating our company  before you purchase any shares of our common stock.  The
risks we  describe  below  are not the only ones we face.  Additional  risks and
uncertainties,  including  those we do not know  about now or that we  currently
deem immaterial, may also adversely affect our business. If any of the following
risks actually occur, our business, financial condition or results of operations
could be materially  adversely affected.  In this case, the trading price of the
common stock could decline and you may lose all or part of your investment.

                                      -2-


RISKS RELATED TO OUR BUSINESS

          WE HAVE A LIMITED OPERATING HISTORY AND HAVE INCURRED LOSSES SINCE OUR
          INCEPTION.  IF WE CONTINUE TO LOSE MONEY,  OUR  OPERATIONS  MAY NOT BE
          FINANCIALLY VIABLE.

          Accent  Color  was  formed  in May  1993 and has a  limited  operating
history.  We have incurred losses in each year since our founding and incurred a
net loss of $9,769,853 (before imputed dividend on preferred stock) for the year
ended December 31, 1998 and a net loss of $3,973,854 (before imputed dividend on
preferred stock) for the first nine months of 1999. As a result of these losses,
as of September 30, 1999, we had an accumulated  deficit of $51,588,818.  Before
any imputed  dividends or charges related to potentially  beneficial  conversion
features  associated  with the  series C  preferred  stock,  we  expect to incur
quarterly net losses  through at least the second quarter of 2000 and a net loss
for fiscal year 2000.  We cannot  assure you that  thereafter we will be able to
achieve or sustain revenue growth, profitability or positive cash flow on either
a  quarterly  or  annual  basis  or that  profitability,  if  achieved,  will be
sustained.

          The  anticipated  increase  in our  operating  expenses  caused by any
expansion of our  manufacturing  and marketing  operations could have a material
adverse effect on our operating results if revenue does not increase at an equal
or greater rate.  Also, our expenses for these and other activities are based in
significant part on our expectations regarding future revenue and are fixed to a
large  extent in the short term.  We may not be able to adjust our spending in a
timely manner to compensate for any unexpected revenue shortfalls.

          WE MAY NEED TO RAISE  ADDITIONAL  CAPITAL  IN THE  FUTURE  TO FUND OUR
          OPERATING AND CAPITAL REQUIREMENTS.

          Since our inception,  we have raised  additional  funding from time to
time as we have increased our marketing,  sales and service  efforts,  continued
our research and development activities for the enhancement of Truecolor Systems
and increased production of our Truecolor Systems. To date, we have financed our
operations through customer payments, borrowings and the sale of debt and equity
securities.

          Although we experienced a slowdown in shipments of our products during
the latter  half of 1999 which we  believe to be due to year 2000  concerns,  we
have received  contractual orders and commitments for Truecolor Systems from our
original equipment  manufacturer ("OEM") customers of approximately $10 million,
which are deliverable in the year 2000.  These currently  anticipated  levels of
revenue and cash flow are subject to many  uncertainties  and cannot be assured.
Further,  we may change our business plans, or unforeseen events may occur which
might  require us to raise  additional  funds.  The need for, and the amount of,
additional funds we may require will depend on many factors, including

          o    the extent and timing of sales of our Truecolor Systems,

                                      -3-


          o    the cost associated with sales,  marketing and customer technical
               support efforts, and

          o    our operating results.

          We cannot assure you that,  if needed,  additional  financing  will be
available,  or available on acceptable  terms. If we are unable to obtain needed
additional  financing or generate  sufficient cash from our  operations,  we may
have  to  reduce  or  eliminate   expenditures  for  research  and  development,
production or marketing of our products, or otherwise curtail or discontinue our
operations.  Any of these  developments  could have a material adverse effect on
our business, financial condition and results of operations.

          WE ARE DEPENDENT ON A SINGLE PRODUCT LINE.

          We do not have a variety of product lines.  We anticipate that we will
derive  substantially all of our revenue in the foreseeable future from sales of
Truecolor  Systems,  related  consumables  and spare parts to our  principal OEM
customers.  If we are unable to  generate  enough  sales of  Truecolor  Systems,
wax-based  ink  and/or  spare  parts  due to  market  conditions,  manufacturing
difficulties or other reasons, we may be unable to continue our business.  Since
we only  have a single  product  line,  we are  particularly  vulnerable  to the
successful  introduction  of  competitive  products  by  existing  or  potential
competitors, including our OEM customers.

          WE HAVE A LIMITED HISTORY OF PRODUCT MANUFACTURING.

          We have a limited  manufacturing history and cannot assure that we can
make a  successful  transition  to  high-volume  production.  So  far,  we  have
manufactured  only limited  quantities  of Truecolor  Systems and  manufacturing
costs have approximated the average selling price of a unit. To make a profit we
must  manufacture  our products in enough  quantities  and at acceptable  costs.
Future  production  in  enough  quantities  may  pose  technical  and  financial
challenges for us. Our failure to  successfully  transition and  manufacture our
products at a cost  adequately  below their  selling price could have a material
adverse effect on our business, financial condition and results of operations.

          WE MAY NOT BE ABLE TO SUCCESSFULLY MARKET OUR PRODUCTS.

          Our  products are  designed  for the  digital,  high-speed  production
printing and  production  publishing  market  segments  that have  traditionally
relied on monochrome print. We cannot assure that we will  successfully  develop
or market our existing or future  products or, if any of these products  achieve
market  acceptance,  that we can grow or even  sustain  market  acceptance.  Any
actual  or  perceived  problems  with  our  products,  whether  or not  they are
significant,  could have a material adverse effect on market acceptance of these
products.  Our existing and  potential  customers may conclude that our products
suffer  from real or  perceived  problems.  Even in the  absence  of any real or
perceived problems, our products may fail to achieve market acceptance.

                                      -4-


          A failure of our products to achieve market  acceptance for any reason
could have a material  adverse effect on our business,  financial  condition and
results of operations.  In addition, the announcement by us or our OEM customers
or competitors of new products and  technologies  could cause customers to defer
purchases of our existing  products,  which could have a material adverse effect
on our business, financial condition and results of operations.

         WE HAVE A CONCENTRATED  CUSTOMER  BASE,  THEREFORE THE LOSS OF A SINGLE
         CUSTOMER COULD NEGATIVELY AFFECT OUR REVENUES AND OPERATING RESULTS.

          We anticipate that sales of our Truecolor Systems and consumables to a
limited number of customers will account for  substantially  all of our revenue.
We have existing contracts with two customers IBM and Xerox (as the successor to
Groupe SET)  ("Xerox").  Generally,  our customers  provide  estimates,  but not
guarantees,  of their future orders.  We cannot assure you that these  customers
will purchase a significant  volume of our  products.  A substantial  difference
between  estimated orders and actual orders by any one of our customers,  or the
failure of our customers to purchase a significant number of our products, could
have a material adverse effect on our business,  financial condition and results
of operations.  We cannot assure you that our OEM  customers,  including IBM and
Xerox, or other companies will not compete with us in the future.

         WE RELY ON THIRD PARTY MARKETING, DISTRIBUTION AND SUPPORT.

          A significant  element of our marketing  strategy is to form alliances
with third parties for the marketing and distribution of our products. We cannot
assure you that

          o    we can  maintain  our  existing  alliances  or form and  maintain
               alliances with other parties;

          o    we  can  satisfy  our  contractual   obligations   with  our  OEM
               customers; or

          o    our OEM customers  will devote  adequate  resources to market and
               distribute our products successfully.

Since our products are marketed and distributed via third parties we have:

          o    a limited  ability to interact with the users of our products and
               to observe their experience with our products;

          o    a lack of  control of the  marketing,  distribution  and  support
               efforts of our OEM customers that may make us less  responsive in
               recognizing  and correcting  any problems  experienced by the OEM
               customers or the end users;

          o    a lack of  control as to the  timing of the  introduction  of our
               products; and

                                      -5-


          o    less  information  regarding  the amount of  inventory  currently
               available and this may reduce our ability to predict fluctuations
               in revenue due to a surplus or a shortage of inventory.

          The  foregoing  results of our reliance on third parties to market and
distribute our products could have a significant adverse effect on our business,
financial  condition and results of operations.  In addition,  any disruption in
our relationships with IBM or Xerox, or any future customer, may have a material
adverse effect on our ability to  successfully  market our Truecolor  Systems to
customers.

          WE ARE DEPENDENT ON A SOLE SOURCE  SUPPLIER FOR A KEY COMPONENT OF OUR
          PRODUCTS.

          We are  dependent  on Spectra,  a wholly owned  subsidiary  of Markem,
Inc.,  as our sole  source  supplier  of ink jet  printheads  and the hot  melt,
wax-based inks used by Truecolor  Systems.  Spectra has agreed to supply us with
ink jet  printheads and wax-based  inks under a supply  agreement,  subject to a
number of  conditions.  We have an  exclusive  right,  under an  agreement  with
Spectra,  to supply  products  including  Spectra's  ink jet  printheads  in the
worldwide  market for printing  color on the output from  specified  high-speed,
monochrome  printers  marketed by Xerox,  IBM and certain other parties  through
December 31, 2002,  however,  we are currently  not in  compliance  with certain
volume purchase  requirements  necessary to maintain such  exclusivity.  We also
have an option to renew this  agreement for an additional  seven year term.  Our
reliance on Spectra involves the risks that we may

          o    be unable to obtain an adequate supply of required  printheads or
               inks from another supplier in the event that Spectra is unable or
               unwilling to do so; and

          o    have a reduced  level of control  over the  quality,  pricing and
               timing of delivery of these items.

          As we increase the  production  of Truecolor  Systems,  we will become
more  reliant  upon  Spectra's  ability  to  manufacture  and  deliver  ink  jet
printheads under the supply agreement. Any interruption in our ability to obtain
Spectra printheads of an acceptable quality within the time frame required by us
at an  affordable  cost could result in delays and  increased  costs which would
have a material adverse effect on our business,  financial condition and results
of operations.

                                      -6-


          WE DEPEND ON MAJOR SUBCONTRACTORS AND SUPPLIERS.

          We  rely  on   subcontractors   and  other  parties  to   manufacture,
subassemble  and perform  certain testing of some modules and parts of Truecolor
Systems.  Currently,  our ink jet printheads are manufactured solely by Spectra.
We currently  perform the final assembly and testing of various Truecolor System
components and of each complete  Truecolor System. We plan to hire other parties
to  manufacture  major  components  and complete  final  assembly and testing of
Truecolor Systems in-house.  If we do not develop  relationships  with, or lose,
these subcontractors or suppliers, or if the subcontractors or suppliers fail to
meet our price, quality, quantity and delivery requirements,  then we may suffer
a material  adverse effect on our business,  financial  condition and results of
operations.

          WE ARE RESPONSIBLE FOR PRODUCT WARRANTIES AND HAVE AGREED TO REPAIR OR
          REPLACE OUR PRODUCTS IF DEFECT RATES ARE EXCESSIVE.

          We  warrant  that  our  Truecolor  Systems  are  free  of  defects  in
workmanship  and materials.  We have also agreed to repair or replace  defective
products  without charge when defect rates are excessive.  We cannot assure that
we will not  experience  more warranty  claims or product  failure rates than we
expected  when we  originally  priced our products  and spare parts.  Any excess
warranty claims or product failure rates could have a material adverse effect on
our business, financial condition and results of operations.

          WE DEPEND ON KEY MANAGEMENT PERSONNEL FOR OUR SUCCESS.

          We are substantially dependent on the capabilities and services of our
key technical and management  personnel,  some of whom have been instrumental in
developing our products and establishing and maintaining strategic relationships
with our key suppliers and major OEM customers.  These personnel include Richard
J. Coburn, our co-founder and chairman of the board of directors, and Charles E.
Buchheit,  our  president  and chief  executive  officer.  Mr.  Buchheit  has an
employment  agreement with us that expires on April 14, 2001.  Mr.  Buchheit may
terminate his employment relationships with us at any time with no penalty other
than the loss of future compensation.

          The loss or interruption of the continued  service of, and the failure
to promptly replace, either of these key personnel could significantly delay and
may prevent the achievement of our business objectives.

          In addition, our future success also depends on our continuing ability
to  identify,  hire,  train and retain  other  highly  qualified  technical  and
managerial personnel. Competition for these employees is intense and increasing.
We may not be able to attract,  assimilate  or retain  qualified  technical  and
managerial  personnel in the future, and the failure of us to do so would have a
material  adverse  effect on our  business,  financial  condition and results of
operations.

                                      -7-


RISKS RELATED TO OUR INDUSTRY

          OUR   SUCCESS   DEPENDS  ON  THE  ABILITY  TO  KEEP  PACE  WITH  RAPID
          TECHNOLOGICAL ADVANCES IN THE HIGH-SPEED PRINTER INDUSTRY.

          The  high-speed   printer   industry  is   characterized  by  evolving
technology and changing  market  requirements.  Our future  success  depends our
ability to continue  to develop  and  manufacture  new  products  and to enhance
existing  products.   Consequently,   the  enhancement  of  our  products  is  a
development  priority.   However,  in  a  new  and  evolving  market,   customer
preferences  can  change  rapidly  and  new  technology  could  render  existing
technology and product inventory obsolete.  Our failure in responding adequately
to changes in our target  market,  in developing or acquiring new  technology or
successfully  conforming  to  market  preferences  could  depress  sales  of our
existing  products and  technologies.  This may result in  declining  prices and
inventory  obsolescence  which  would  have a  material  adverse  effect  on our
business, financial condition and results of operations.

          OUR FAILURE TO ADEQUATELY  PROTECT OUR  INTELLECTUAL  PROPERTY  RIGHTS
          COULD HARM OUR BUSINESS.

          Because our business depends on technology, we believe the maintenance
of our patents,  trademarks,  service marks and other proprietary  rights in our
unpatented  know-how and common law  trademarks  and service marks are important
for our success and competitive position. We have secured three patents from the
U.S. Patent and Trademark office relative to the mechanical  design of our paper
handling  and  color  printing  system,  which  form the  core of the  Truecolor
Systems.  In addition,  we have applied for  additional  U.S. and foreign patent
protection relative to our products.

          Our  efforts  to  detect  misappropriation  of  these  rights  may  be
inadequate to prevent  others,  including our OEM customers,  from imitating our
products and  infringing on our  intellectual  property  rights.  It is possible
that, if challenged,  our  intellectual  property rights may be narrowed or held
invalid by a court of competent jurisdiction. The sale of our copied products by
others could  depress  sales of our products  which could  materially  adversely
impact our business, financial condition and results of operations.

          WE RELY ON THE EFFORTS OF A MAJOR SUPPLIER TO PROTECT ITS INTELLECTUAL
          PROPERTY RIGHTS.

          We have an exclusive right, under an agreement with Spectra, to supply
products including Spectra's ink jet printheads to our customers.  To the extent
that wax-based  inks and ink jet  printheads  purchased from Spectra are covered
under  patents or licenses,  we rely on  Spectra's  rights under its patents and
licenses and Spectra's willingness and ability to enforce them. We cannot assure
that  Spectra  will be willing or able to enforce its patents and  maintain  its
licenses  against  third  parties.  Any  unwillingness  or inability to do so by
Spectra  could  have  a  material  adverse  effect  on our  business,  financial
condition and results of operations.

                                      -8-


          CLAIMS MADE BY THIRD PARTIES THAT WE INFRINGE THEIR PROPRIETARY RIGHTS
          COULD RESULT IN INCREASED COSTS.

          We believe  that our  products  and  technology  do not  infringe  any
existing  proprietary  rights of others.  Third  parties  may,  however,  assert
infringement  claims against us in the future.  We may be unable to successfully
defend against these claims. For example, third party competitors, including our
OEM customers,  could assert rights in our intellectual property rights or claim
that the products we offer have violated their proprietary  rights. In addition,
our competitors may have filed for patent protection that is not as yet a matter
of public knowledge.  Moreover, a court could interpret a third-party's  patents
broadly so as to cover some of our products.

          We could incur substantial costs and diversion of management resources
with  respect to the  defense  of any claims  relating  to  proprietary  rights,
whether or not the assertion of the claim is valid,  which could have a material
adverse effect on our business,  financial  condition and results of operations.
Furthermore,  parties  making  these  claims  could  secure a judgment  awarding
substantial  damages,  as well as injunctive or other  equitable  relief,  which
could effectively block our ability to make, use, sell, distribute or market its
products and services in the U.S. or abroad. Any unfavorable judgment could have
a material  adverse effect on our business,  financial  condition and results of
operations.

          In the event a claim relating to proprietary technology or information
is asserted  against us, we may seek licenses of that  intellectual  property in
order to use  technology we need to conduct our  business.  We cannot assure you
that we could obtain a license on commercially  reasonable  terms, if at all, or
that the terms of any offered licenses will be acceptable. The failure to obtain
the necessary  licenses or other rights could preclude the sale,  manufacture or
distribution  of our  products  and,  therefore,  could have a material  adverse
effect on our business, financial condition and results of operations.

          We are required to indemnify  any of our OEM  customers  against third
party infringement  claims. As a result, our business,  financial  condition and
results  of  operations  could  be  materially  adversely  affected  if any such
infringement claims are asserted against our OEM customers.

          COMPETITION  COULD PREVENT OUR EFFORTS TO ESTABLISH MARKET  ACCEPTANCE
          FOR OUR PRODUCTS AND HARM OUR BUSINESS.

          Our  competitors  may be  able  to  develop  products  that  are  more
attractive to customers than our products.  We compete,  in significant part, on
the basis of advanced proprietary technology in the areas of paper handling, ink
jet color  printing and  interface  software  which allows our products to print
variable data, in multiple standard and custom colors at high speeds.

         Competition to supply high-speed color printing is fragmented.  Many of
our competitors and potential  competitors have substantially  greater financial
and technical

                                      -9-


resources,  longer  operating  histories,  greater  name  recognition  and  more
extensive  customer  bases  that could be used to gain  market  share or product
acceptance.  In  addition  to direct  competition  from  other  firms  utilizing
high-speed color  technologies,  we face potential direct competition from firms
improving  technologies  used in low-speed to  medium-speed  color  printers and
indirect competition from firms producing pre-printed forms.

          Other companies may introduce  products or product  improvements based
on  new  technologies  with  little  or  no  advance  notice.  Manufacturers  of
high-speed,  monochrome  printers may also, in time,  develop comparable or more
effective  color  capability  within  their own  products  which may  render our
products  obsolete.  There can be no  assurance  that we will be able to compete
against future  competitors  successfully or that competitive  pressures we face
will not have a material  adverse  effect upon the success of our  business  and
financial condition.

          OUR OEM CUSTOMERS MARKET AND SELL OUR PRODUCTS INTERNATIONALLY.

          As part of our business  strategy,  our OEM customers  market and sell
our products to end users  outside the United  States.  International  sales are
subject to certain inherent risks, including:

          o    unexpected changes in regulatory requirements;

          o    export and import restrictions, tariffs and other trade barriers;

          o    government controls and potential political instability; and

          o    potentially adverse tax consequences.

          Any of the above factors could have a material  adverse  effect on our
business, financial condition and results of operations.

RISKS RELATED TO THE OFFERING

          WE HAVE A LIMITED  MARKET FOR OUR COMMON  STOCK AND OUR STOCK PRICE IS
          VOLATILE.

          Our   common   stock  is   currently   quoted   and   traded   in  the
over-the-counter  market on the  "Electronic  Bulletin  Board"  of the  National
Association of Securities  Dealers,  Inc under the symbol "ACLR." Trading on the
NASD Over-The-Counter Bulletin Board is sporadic and can be highly volatile. The
market price of our common stock has  fluctuated in the past and may continue to
be volatile in the future. As a result of these factors, an investor will likely
find it more difficult to sell our stock or to obtain accurate  quotations as to
the price of our stock  than if the stock were  traded on a national  securities
exchange or on the Nasdaq national market.

                                      -10-


          OUR QUARTERLY  OPERATING RESULTS MAY NOT BE A GOOD INDICATOR OF FUTURE
          RESULTS AND MAY FLUCTUATE  SIGNIFICANTLY,  WHICH COULD RESULT IN LOWER
          PRICES FOR OUR STOCK.

          We expect our quarterly  operating results to fluctuate  significantly
in the future  based upon a number of  factors,  some of which are  outside  our
control. As a result, it is possible that our operating results may be below the
expectations  of investors  in some future  period.  If this were to occur,  the
trading price of our common stock would likely decline, perhaps significantly.

          The factors  which  affect  whether our  operating  results  fluctuate
include:

          o    the volume, timing, delivery and acceptance of customer orders;

          o    the rate of customer and end-user  acceptance of our products and
               the volume or nature of warranty claims;

          o    the market acceptance of host printing systems offered by our OEM
               customers;

          o    changes in our pricing  policies or those of our OEM customers or
               competitors;

          o    the relative proportion of printer and consumables sales;

          o    the  timely  availability  of  sufficient  volume of sole  source
               components;

          o    fluctuations in our research and development expenditures;

          o    the  availability  of financing  arrangements  for certain of our
               customers; and

          o    economic  conditions  specific to the high-speed printer industry
               and general economic conditions.

          Additionally,   because  the   purchase  of  a  printing   system  and
peripherals  is  expensive,  it may take a  significant  amount of time from the
first sales  negotiations  for a customer to complete and pay for its  purchase.
Historically,  certain  periods of the year are more  profitable than others for
the  sale  of  major  equipment  such  as  our  Truecolor  Systems.   We  expect
fluctuations  in our revenue from quarter to quarter to apply to the purchase of
our systems.  Since we sell few units at high average prices,  a delay in either
the sale or the receipt of the purchase  price for only a few units could have a
considerable adverse effect on the results of operations for a fiscal quarter.

          A significant portion of our operating expenses is relatively fixed in
the short term, and planned  expenditures  are based on sales  forecasts.  Sales
forecasts by our customers are  generally not binding.  Revenue  levels may fall
below expectations and disproportionately  affect operating results since only a
small portion of our expenses vary

                                      -11-


with revenue in the short term,  which could have a material  adverse  effect on
our business, financial condition and results of operations.

          OUR DIVIDEND POLICY COULD DEPRESS OUR STOCK PRICE.

          We have never  declared or paid  dividends  on our common stock and do
not anticipate  declaring or paying any dividends in the foreseeable  future. We
plan to retain any future earnings to reduce our accumulated deficit and finance
growth. As a result,  our dividend policy could depress the market price for our
common stock.

          WE HAVE ANTI-TAKEOVER  PROVISIONS IN PLACE THAT COULD DELAY OR PREVENT
          A CHANGE IN CONTROL AND THEREFORE HURT OUR SHAREHOLDERS.

          Our Restated  Certificate of  Incorporation  contains  provisions that
could  discourage a proxy contest or make more  difficult the  acquisition  of a
substantial  block of our common stock.  Our directors are elected on a rotating
basis  each  year.  This  makes a  change  in the  composition  of the  board of
directors  more  difficult and could make it more difficult for a third party to
acquire control of the company, even if such change of control might benefit the
shareholders.  In addition,  the board of  directors  may issue shares of common
stock and preferred  stock which, if issued,  could dilute and adversely  affect
various  rights  of the  holders  of shares  of  common  stock.  If the board of
directors decides to issue this stock it could discourage an unsolicited attempt
to acquire us.

          We are  subject to the  Connecticut  Business  Corporation  Act,  some
provisions of which might prevent a change of control,  even a change of control
that might benefit the company and its shareholders.

          SHARES  ELIGIBLE FOR PUBLIC SALE AFTER THIS OFFERING  COULD  ADVERSELY
          AFFECT OUR STOCK PRICE.

          Future  sales in the public  market of  substantial  amounts of common
stock or the  perception  that such sales may occur could cause the market price
of our  stock to drop  significantly,  even if our  business  is doing  well.  A
decline in our stock  price  could  also  impair  our  ability to raise  capital
through the offering of additional debt or equity securities.  Such future sales
of common stock includes shares:

          o    issuable  upon the  conversion  of shares  of series C  preferred
               stock;

          o    issuable upon the exercise of the warrants we have granted,

          o    registered  and  sold  because  of the  exercise  of  outstanding
               registration rights; and/or

          o    issuable  upon the  exercise  of  other  outstanding  options  or
               warrants.

                                      -12-


          As of  February  8, 2000,  we had  21,973,321  shares of common  stock
issued and outstanding.  If all the outstanding  shares of series C and series B
preferred stock are




converted into shares of common stock and if all of the outstanding warrants and
options are exercised,  we will have  approximately  41,512,567 shares of common
stock issued and outstanding.

                           FORWARD-LOOKING STATEMENTS

          In this prospectus and the documents that we incorporate by reference,
we make statements that relate to our future plans, objectives, expectations and
intentions that involve risks and uncertainties.  We have based these statements
on  our  current   expectations  and  projections  about  future  events.  These
statements may be identified by the use of words such as "expect," "anticipate,"
"intend,"  "plan,"  "believe"  and  "estimate"  and  similar  expressions.   Any
statements that refer to expectations, projections or other characterizations of
future events or circumstances are forward-looking statements within the meaning
of the Private Securities  Litigation Reform Act of 1995, and are subject to the
safe harbor created by that Act.

          Forward-looking    statements    necessarily    involve    risks   and
uncertainties.  Our actual results could differ  materially from those discussed
in,  or  implied  by,  these  forward-looking  statements.  Factors  that  could
contribute to such differences  include, but are not limited to, those discussed
in the "Risk Factors"  section at page 2 and elsewhere in this  prospectus.  The
factors set forth in the Risk Factors  section and other  cautionary  statements
made in this prospectus should be read and understood as being applicable to all
related forward-looking statements wherever they appear in this prospectus.

          All   subsequent   written   and   oral   forward-looking   statements
attributable  to us are expressly  qualified in their entirety by the cautionary
statements.   You  are   cautioned   not  to  place  undue   reliance  on  these
forward-looking statements,  which speak only as of their dates. We undertake no
obligations to publicly update or revise any forward-looking statements, whether
as a result of new information, future events or otherwise.

                       WHERE YOU CAN FIND MORE INFORMATION

          We are a public company and file annual, quarterly and special reports
and other  information with the SEC. You may read and copy and documents we file
at the SEC's Public  Reference Room, 450 Fifth Street,  N.W.,  Washington,  D.C.
20549.  You may  obtain  further  information  on the  operation  of the  Public
Reference  Room by calling the SEC at  1-800-SEC-0330.  You can obtain copies of
this material from the Public  Reference  Section of the SEC,  Washington,  D.C.
20549, at prescribed  rates. Our reports,  proxy and information  statements and
other  information  are also  available to the public at the SEC's web site. The
Internet address of that site is http://www.sec.gov.

          This  prospectus is only part of a registration  statement on Form S-3
that we have filed with the SEC under the  Securities  Act and  therefore  omits
certain information

                                      -13-


contained  in the  registration  statement.  We have  also  filed  exhibits  and
schedules  with  the   registration   statement  that  are  excluded  from  this
prospectus,  and you should  refer to the  applicable  exhibit or schedule for a
complete  description  of any  statement  referring  to any  contract  or  other
document.  You may inspect a copy of the registration  statement,  including the
exhibits and  schedules,  without  charge at the SEC's public  reference room or
through its web site.

                      DOCUMENTS WE INCORPORATE BY REFERENCE

          The SEC allows us to  "incorporate  by reference"  the  information we
file with it, which means that we can disclose  important  information to you by
referring you to those documents. The information we incorporate by reference is
an important part of this  prospectus,  and later  information that we file with
the SEC will automatically update and supersede this information. We incorporate
by reference the documents listed below, and any future filings we make with the
SEC under Section 13(a),  13(c),  14 or 15(d) of the Securities  Exchange Act of
1934 before the  termination of the offering of the securities  contemplated  by
prospectus. The documents we incorporate by reference are:

          o    our annual report on Form 10-K/A for the year ended  December 31,
               1998;

          o    our quarterly reports on Form 10-Q/A for the quarters ended March
               31,  1999,  June 30, 1999 and on Form 10-Q for the quarter  ended
               September 30, 1999; and

          o    our  current  reports  on Form 8-K filed with the SEC on July 15,
               July 26 and December 17, 1999;

          o    The description of our common stock in our registration statement
               on Form 8-A, which became effective December 23, 1996,  including
               any amendment or report filed to update this description.

          You may  request a copy of these  filings  (other  than an  exhibit to
those filings unless we have specifically incorporated that exhibit by reference
into the filing),  at no cost,  by writing or  telephoning  us at the  following
address:

                          Accent Color Sciences, Inc.,
                            800 Connecticut Boulevard
                        East Hartford, Connecticut, 06108
                       Attention: Chief Financial Officer
                            Telephone: (860) 610-4000

          Our  internet web address is  http://www.accentcolor.com.  Information
contained on our web site or in our promotional  literature is not  incorporated
into this prospectus.

          You should rely only on the  information  contained or incorporated by
reference in this  prospectus.  We have not  authorized  anyone  (including  any
broker  or  salesman)  to  provide  you with  information  different  from  that
contained  in  this  prospectus.  If  anyone  provides  you  with  different  or
inconsistent  information,  you should not rely on it. The selling  stockholders
are  offering to sell and seeking  offers to buy shares of our common stock only
in  jurisdictions  where offers and sales are permitted.  You should assume that

                                      -14-


the  information  contained in this  prospectus  is accurate only as of the date
hereof.  You should not assume that this  prospectus is accurate as of any other
date.

                              SELLING STOCKHOLDERS

          The following  table sets forth the name of each selling  stockholder,
the  number  of  shares  of  common  stock  beneficially  owned  by the  selling
stockholder  as of February 11, 2000, the number of shares being offered by each
selling  stockholder and the number and (where  appropriate,  the percentage) of
shares held by the beneficial  owner after  completion of the offering  assuming
that all shares offered by the selling stockholders are sold. All information is
taken  from  or  based  on  ownership  filings  made by such  persons  with  the
Securities and Exchange  Commission or upon  information  provided to us by such
person or their agents.  Unless  otherwise  indicated,  the persons named in the
table below have sole voting and investment  power with respect to all shares of
common stock shown as beneficially owned by them.

          The  shares  being  offered  are being  registered  to  permit  public
secondary  trading,  and the selling  stockholders  may offer all or part of the
shares for resale from time to time. However, the selling stockholders are under
no  obligation  to sell all or any  portion of the  shares  nor are the  selling
stockholders  obligated to sell any shares  immediately  under this  prospectus.
Because the selling stockholders may sell all or part of their shares, we cannot
estimate the number of shares a selling  stockholder  will hold upon termination
of any offering made pursuant to this registration statement.

          Pursuant to Rule 416 under the Securities  Act,  selling  stockholders
may also offer and sell  shares  issued  with  respect to the series C preferred
stock  and/or the  warrants  as a result of stock  splits,  stock  dividends  or
similar transactions. The chart below is not intended to constitute a prediction
as to the number of shares of common  stock  into  which the series C  preferred
stock will be converted and the warrants that will be exercised.

                                      -15-





                                          Number of Shares                           Shares Beneficially Owned
                                         Beneficially Owned      Shares to be         After the Offering (1)(2)
                                           Prior to the            Included
     Name of Selling Stockholder            Offering (1)        in the Offering         Number          Percent
     ---------------------------        -------------------     ---------------       ----------        -------

                                                                            
Accrued Investments, Inc. ..........          100,000                62,000             38,000             *
Donald R. Allred(3) ................          161,750                43,750            118,000             *
James S. Allsopp ...................          435,928               250,000            185,928             *
Banque Jenni & Cie, S.A ............          100,000                70,000             30,000             *
Robert A. Bedingfield ..............           62,500                62,500                  0               0
Bexley Enterprises Limited .........          636,986               500,000            136,986             *
Joseph T. Brophy(4) ................          330,649               250,000             80,649             *
William P. Brown ...................           50,000                45,000              5,000             *
Charles Buchheit(5) ................          225,000               100,000            125,000             *
Frank J. Campbell III ..............          172,000               140,000             32,000             *
Deed of Trust of F. J. Campbell ....           70,526                60,000             10,526             *
Settlor Dtd 12/30/96, C. Crochiere,
K. Lynam & J. Meyers Co-TTEES(6)
Frank J. Campbell III and Richard A            75,000                75,000                  0               0
Hansen TTEES Trust U/W Jane D ......
Campbell
Richard J. Coburn(7) ...............          484,303                25,000            459,303             1.3
Thomas D. Cunningham ...............          250,000               250,000                  0               0
Robert G. Donovan ..................           75,698                62,500             13,698             *
Samuel Garre III ...................           70,000                40,000             30,000             *
Richard C. Goodwin .................          150,000               150,000                  0               0
E. Balkeley and Lila K. Griswold ...           77,619                62,500             15,119             *
PMG Eagle Fund .....................        3,097,500             2,687,500            410,000             1.2
Richard Hodgson(8)(9) ..............          198,750               100,000             98,750             *
James J. Kim .......................          120,000               120,000                  0               0
Richard G. Larsen ..................          125,000               125,000                  0               0
Brian Leung Hung Tak ...............          636,986               500,000            136,986             *
Robert A. Leverone .................           73,349                62,500             10,849             *
Luzon Investments Ltd. .............        1,687,972             1,000,000            687,972             2.0
Irving L. Mazer(10) ................           65,215                50,000             15,215             *
Anthony T.S. Montagu ...............          100,000                76,000             24,000             *
Albert G. Nickel ...................          138,698               125,000             13,698             *
Pacific Alliance Limited, LLC ......           70,000                70,000                  0               0
David Parke ........................           20,000                20,000                  0               0


                                      -16-





                                          Number of Shares                           Shares Beneficially Owned
                                         Beneficially Owned      Shares to be         After the Offering (1)(2)
                                           Prior to the            Included
     Name of Selling Stockholder            Offering (1)        in the Offering         Number          Percent
     ---------------------------        -------------------     ---------------       ----------        -------

                                                                            
Orbis Pension Trustees Limited .......        2,687,500            2,437,500            250,000              *
David B. Payne .......................           25,000               25,000                  0              0
George L. Perry ......................          250,000              250,000                  0              0
Robert J. Petras and Christine M .....           25,000               25,000                  0              0
Petras
Willard F. Pinney Jr.(8)(11) .........          144,799               25,000            119,799              *
Leonide C. Prince ....................          100,000              100,000                  0              0
FH Reichel Jr. TTEE FBO Marion R .....          255,000              100,000            155,000              *
Reichel U/A 2/25/66
Carol A. Sharp .......................          250,000              250,000                  0              0
SS Family Partnership ................           15,000               15,000                  0              0
Elizabeth Steele(12) .................          219,118                1,500            217,618              *
Robert H. Steele(8)(13) ..............          219,118              112,500            106,618              *
Dr. Gershon Stern ....................           38,000               38,000                  0              0
Sunapee Ltd. Partnership .............          100,000              100,000                  0              0
Kristine Szabo .......................          277,396              250,000             27,396              *
Frederick C. Tecce ...................           30,000               30,000                  0              0
Upgrade Inc. .........................          100,000              100,000                  0              0
Waterhouse Nominees LTD ..............          115,000              100,000             15,000              0
Deed of Trust of Holly E. Zug Settlor            25,000               25,000                  0              0
DTD 8/5/97 Thomas V. Zug Trustee
Connecticut Innovations, Inc. ........        1,250,000            1,250,000                  0              0

                                                     TOTAL:       12,418,750


*    Represents  beneficial  ownership of less than 1% of the outstanding shares
     of common stock.

(1)  Beneficial  ownership is determined  in  accordance  with Rule 13d-3 of the
     Securities Exchange Act of 1934, as amended. Shares of common stock subject
     to options, warrants, rights or conversion privileges currently exercisable
     or exercisable  within 60 days of February 11, 2000 are deemed  outstanding
     for computing the percentage of the person holding such options,  warrants,
     rights  or  conversion  privileges  but  are  not  deemed  outstanding  for
     computing the percentage ownership of any other person.

(2)  Assumes all shares offered are sold in the offering.

                                      -17-


(3)  Mr.  Allred serves as the director of R&D and new business  development  of
     Accent Color.  Includes 180,000 shares of common stock subject to currently
     exercisable options granted pursuant to the 1995 Stock Incentive Plan.

(4)  Mr. Brophy serves as a director of Accent Color.  Includes 40,000 shares of
     common stock subject to currently  exercisable  options granted pursuant to
     the 1995 Stock Incentive Plan.

(5)  Mr. Buchheit serves as the President,  CEO, CFO and as a director of Accent
     Color.   Includes  5,000  shares  of  common  stock  subject  to  currently
     exercisable  options granted  pursuant to the 1995 Stock Incentive Plan and
     100,000 shares of common stock subject to currently exercisable warrants.

(6)  Includes  10,526  shares of common stock  subject to currently  exercisable
     warrants.

(7)  Mr.  Coburn  serves as the  Chairman  of the Board of  Directors  of Accent
     Color.  Includes  23,334  shares  of  common  stock  subject  to  currently
     exercisable options granted pursuant to the 1995 Stock Incentive Plan.

(8)  Includes  70,000  shares of common stock  subject to currently  exercisable
     options granted pursuant to the 1995 Stock Incentive Plan.

(9)  Mr. Hodgson serves as a director of Accent Color.  Includes 3,750 shares of
     common stock subject to currently exercisable warrants.

(10) Includes  10,215  shares of common stock  subject to currently  exercisable
     warrants

(11) Mr.  Pinney  serves as the  Secretary  and as a director  of Accent  Color.
     Includes  30,000  shares of common stock  subject to currently  exercisable
     warrants granted to Murtha,  Cullina,  Richter & Pinney LLP, counsel to the
     company, of which Mr. Pinney is a partner.

(12) Includes  1,500  shares of common stock  subject to  currently  exercisable
     warrants and 200,500  shares  beneficially  owned by Richard  Steele,  Mrs.
     Steele's  spouse,  as to all of  which  Mrs.  Steele  disclaims  beneficial
     ownership.

(13) Mr. Steele serves as a director of Accent Color.  Includes 17,118 shares of
     common  stock  owned by Mr.  Steele's  spouse,  Elizabeth  Steele and 1,500
     shares of common stock subject to currently  exercisable warrants issued to
     Elizabeth  Steele,  as to all of  which  Mr.  Steele  disclaims  beneficial
     ownership.

                                 USE OF PROCEEDS

          All the shares  offered by this  prospectus  are being offered for the
account of the selling  stockholders.  Accordingly,  all net  proceeds  from any
sales of common stock made  hereunder  will go to the selling  stockholders.  We
will  receive  the  exercise  price of any  warrants  exercised  by the  selling
stockholders.  We will use any proceeds  received  from the exercise of warrants
for working capital and general corporate purposes.

                                      -18-


                              PLAN OF DISTRIBUTION

          We are  registering  the  shares  of  common  stock  offered  in  this
prospectus   on  behalf  of  the   selling   stockholders.   This   offering  is
self-underwritten;  neither the  selling  shareholders  nor we have  employed an
underwriter  for the sale of common stock by the selling  shareholders.  We have
agreed to pay the expenses of registering  the shares under the Securities  Act,
including  registration and filing fees, blue sky expenses,  printing  expenses,
accounting fees,  administrative expenses and our own counsel fees. We have also
agreed  to  indemnify  the  selling  stockholders  and each of  their  officers,
directors, members, employees, partners, agents and each person who controls any
of the selling stockholders against certain expenses,  claims,  losses,  damages
and  liabilities  (or  action,  proceeding  or  inquiry  by  any  regulatory  or
self-regulatory organization in respect thereof).

          The  selling   stockholders  or  any  of  the  selling   stockholders'
transferees   or   successors   in  interest  may  offer  the  shares  for  sale
periodically:

o    in the over-the-counter market;

o    on one or more exchanges on which the shares are then listed (if any);

o    in privately negotiated transactions;

o    in an underwritten offering;

o    in a combination of the above methods; or

o    by any other legally available means.

          The sale of any the shares may be made at market prices  prevailing at
the time of the sale, at prices  related to the  prevailing  market  prices,  at
negotiated prices, or at fixed prices.

          In  addition,   the  selling   stockholders  may  enter  into  hedging
transactions  with  broker-dealers  who may  engage in short  sales of shares of
common stock in the course of hedging the positions they assume with the selling
stockholders.  The  selling  stockholders  may also enter  into  option or other
transactions   with   broker-dealers   that   require   that   delivery  by  the
broker-dealers of the shares,  which shares may be resold thereafter pursuant to
this prospectus.

                                      -19-


          The selling  shareholders may sell their shares directly to purchasers
or to or through broker-dealers,  acting as agents or principals.  You should be
aware that these  broker-dealers may receive compensation for their services and
it is  possible  that  a  particular  broker-dealer's  compensation  may  exceed
customary commissions. The selling stockholders and/or any broker-dealers acting
in connection with the sale of the shares may be deemed to be underwriters under
Section  2(11)  of the  Securities  Act.  Therefore,  any  commissions  or other
compensation  received by them and any profits realized by them on the resale of
the  shares as  principals  may be deemed  underwriting  compensation  under the
securities laws.  Neither we nor any selling  stockholder can presently estimate
the amount of the compensation.

          We have not been advised,  as of the date of this  prospectus,  of any
existing arrangements between any selling stockholder and any other stockholder,
broker, dealer, underwriter or agent relating to the sale or distribution of the
shares.

          Each selling  stockholder  and any other  persons  participating  in a
distribution  of  securities  will be subject to  applicable  provisions  of the
Exchange Act and the rules and regulations  thereunder,  including Regulation M,
which may restrict certain activities of selling  stockholders and other persons
participating  in a  distribution  of  securities  and limit the timing of their
purchases  and sales of  securities.  Furthermore,  under  Regulation M, persons
engaged in a  distribution  of securities  are  prohibited  from  simultaneously
engaging  in market  making and certain  other  activities  with  respect to the
securities  for  a  specified  period  of  time  before  the  beginning  of  the
distributions  subject  to  specified  exceptions  or  exemptions.  All  of  the
foregoing may affect the  marketability  of the securities  offered  pursuant to
this registration statement.

          Any  securities  covered  by this  prospectus  that  qualify  for sale
pursuant to Rule 144 under the Securities Act may be sold under that rule rather
than pursuant to this prospectus.

          There can be no assurance that the selling  stockholders will sell any
or all of the shares of common stock offered by them hereunder.

                                  LEGAL MATTERS

          Counsel for Accent Color,  Murtha,  Cullina,  Richter and Pinney, LLP,
CityPlace I, 185 Asylum Street, Hartford,  Connecticut 06103-3469,  has rendered
an opinion to the effect that the common  stock  offered for resale  pursuant to
this  registration  statement  is  duly  and  validly  issued,  fully  paid  and
non-assessable.  Murtha, Cullina,  Richter & Pinney LLP owns warrants to acquire
up to 30,000 shares of our common stock at an exercise price of $1.19 per share.

          Willard F. Pinney, Jr., a partner in Murtha, Cullina, Richter & Pinney
LLP, is a stockholder  of Accent  Color.  Mr. Pinney has served as our Corporate
Secretary since 1993 and has served as a director since 1996.

                                      -20-



                                     EXPERTS

         The financial  statements  incorporated in this prospectus by reference
to Accent  Color's  Annual Report on Form 10-K/A for the year ended December 31,
1998   have   been   so    incorporated   in   reliance   on   the   report   of
PricewaterhouseCoopers  LLP, independent accountants,  given on the authority of
PricewaterhouseCoopers LLP as experts in auditing and accounting.

                                      -21-


                                     PART II

                     INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

          The following table sets forth our estimates of the expenses  incurred
in connection with the sale of common stock being registered,  all of which will
be paid by us.

SEC registration fee                                               $2,926
Legal fees and expenses                                           $10,000
Accounting fees and expenses                                       $5,000
Miscellaneous fees and expenses                                    $2,500
                                                TOTAL:            $20,426

          The selling stockholder will pay all commissions,  transfer taxes, and
the fees and expenses of counsel to the selling stockholders.

ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

          Accent Color is a Connecticut  corporation.  Sections  33-770  through
33-778 of the Connecticut Business Corporations Act provide that, unless limited
by its certificate of incorporation,  a corporation shall indemnify any director
or officer of the corporation  against  reasonable  expenses  incurred by him in
connection  with  any  action,  suit or  proceeding  in  which  he is made or is
threatened  to be made a party by reason of having been a director or officer of
the  corporation  if he was wholly  successful  in the action,  on the merits or
otherwise.

          In  addition,   these  sections  of  the   Connecticut  Act  permit  a
corporation by action of its board of directors to indemnify an individual  made
a party to a proceeding  because he was a director or officer of the corporation
if:

o    he or she conducted himself in good faith, and

o    he or she  reasonably  believed  (1) in the case of conduct in his official
     capacity with the corporation, his conduct was in the best interests of the
     corporation  and (2) in all other cases,  that his conduct was at least not
     opposed to the best interests of the corporation and

o    in the case of any criminal  proceeding,  he or she had no reasonable cause
     to believe his or her conduct was unlawful.

          Section  33-771 also provides  that a corporation  may not indemnify a
director or officer (1) in  connection  with a proceeding  by or in the right of
the  corporation  in which

                                      -22-


the director or officer was held liable to the  corporation or (2) in connection
with any other proceeding  charging improper personal benefit to the director or
officer in which he




was adjudged liable on the basis that personal  benefit was improperly  received
by him, whether or not the action involved was taken in his official capacity.

          Our  Restated   Certificate  of  Incorporation   limits  the  personal
liability of a director to the company or its  shareholders for monetary damages
for  breach  of  duty  as a  director,  to an  amount  equal  to the  amount  of
compensation  received by the director for serving  during the calendar  year in
which the violation occurred.  This limit on liability is subject to a number of
exceptions,  including  violations involving a knowing and culpable violation of
law, a breach of duty which  enables a director  or an  associate  to receive an
improper  personal  gain,  conduct  showing a lack of good  faith and  conscious
disregard  of  duty  to the  company,  a  sustained  and  unexcused  pattern  of
inattention, or the approval of an illegal distribution of assets of the company
to its shareholders.

          For purposes of determining  the receipt  improper  personal gains, an
"associate" is defined as (1) any corporation or organization of which an Accent
Color  director  is an officer or partner or is,  directly  or  indirectly,  the
beneficial  owner of ten percent or more of any class of voting  stock,  (2) any
trust or other  estate in which a director  has at least ten percent  beneficial
interest or as to which a director  serves as trustee or in a similar  fiduciary
capacity  and (3) any  relative or spouse of a director,  or any relative of the
spouse who has the same name as the Accent Color director.

          In addition, we also maintain a directors' and officers' insurance and
reimbursement policy.

Item 16.  EXHIBITS

          Exhibit Index

      3(i)         Restated Certificate of Incorporation of the Registrant, as
                   amended *

      3(ii)        Certificate of Amendment to Restated Certificate of
                   Incorporation**

      3(iii)       Bylaws of the Registrant, as amended December 29, 1996***

      5            Opinion of Murtha, Cullina, Richter and Pinney, LLP

      10(i)        Form of Securities Purchase Agreement dated as of
                   November 30, 1999

      10(ii)       Certificate of Designations, Preferences and Rights of Series
                   C Convertible Preferred Stock

      10(iii)      Form of Warrant Agreement dated as of Nov. 30, 1999

                                      -23-


      10(iv)       Form of Registration Rights Agreement dated as of
                   November 30, 1999

      23(i)        Consent of Murtha, Cullina, Richter and Pinney, LLP (included
                   in the opinion under Exhibit 5)

      23(ii)       Consent of PricewaterhouseCoopers LLP

      24           Power of attorney pursuant to which this registration
                   statement is signed by certain directors

* incorporated by reference to Exhibit 3(ii) to Accent Color's Current Report on
Form 8-K dated January 9, 1998 and filed with the SEC.

** incorporated by reference to Exhibit 3(i) to Accent Color's Current Report on
Form 8-K dated January 9, 1998 and filed with the SEC.

***  incorporated  by reference to Exhibit 3(ii) to Accent Color's  registration
statement on Form S-3 and filed with the SEC on December  30,  1997,  as amended
(file no. 333-43467).

Item 17.  UNDERTAKINGS

          The undersigned registrant undertakes:

          (1) to file,  during  any  period  in which  offers or sales are being
made, a post-effective amendment to this registration statement:

          (i) To include  any  prospectus  required  by Section  10(a)(3) of the
Securities  Act of 1933,  to the  extent  that the  information  required  to be
included in the  post-effective  amendment is not contained in periodic  reports
filed by Accent  Color with or  furnished  to the SEC  pursuant to Section 13 or
Section  15(d)  of the  Securities  Exchange  Act of 1934  and  incorporated  by
reference herein;

          (ii) To reflect in the  prospectus  any facts or events  arising after
the  effective  date  of  the   registration   statement  (or  the  most  recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental change in the information  expressed in the registration
statement,  to the extent  that the  information  required to be included in the
post-effective  amendment is not  contained in periodic  reports filed by Accent
Color with or furnished  to the SEC  pursuant to Section 13 or Section  15(d) of
the Securities Exchange Act of 1934 and incorporated by reference herein; and

          (iii) To include any significant  information with respect to the plan
of distribution not previously  disclosed in the  registration  statement or any
significant change to the information in the registration statement.

          (2) That,  for the  purpose of  determining  any  liability  under the
Securities  Act,  each  post-effective  amendment  shall be  deemed  to be a new
registration  statement

                                      -24-


relating to the securities  offered  therein,  and the offering of securities at
that time shall be deemed to be the initial bona fide offering thereof.

          (3) To remove from registration by means of a post-effective amendment
any of the securities  being registered that remain unsold at the termination of
the offering.

          The   undersigned   registrant   undertakes   that,  for  purposes  of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to Section  13(a) or Section 15(d) of the
Exchange Act that is  incorporated by reference in this  registration  statement
shall be deemed to be a new  registration  statement  relating to the securities
offered in that registration  statement,  and the offering of securities at that
time shall be deemed to be the initial bona fide offering thereof.

          Insofar  as   indemnification   for  liabilities   arising  under  the
Securities Act may be permitted to directors,  officers and controlling  persons
of the  registrant  pursuant to the  foregoing  provisions,  or  otherwise,  the
registrant  has been advised that in the opinion of the  Securities and Exchange
Commission  the  indemnification  is against  public  policy as expressed in the
Securities Act and is, therefore,  unenforceable. If a claim for indemnification
against these liabilities  (other than the payment by the registrant of expenses
incurred or paid by a director,  officer or controlling person of the registrant
in the  successful  defense of any action,  suit or proceeding) is asserted by a
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether indemnification by it is against public policy
as  expressed  in  the  Securities  Act  and  will  be  governed  by  the  final
adjudication of the issue.

                                      -25-


                                   SIGNATURES

          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this registration
statement to be signed on its behalf by the undersigned, who is duly authorized,
in the City of East Hartford,  State of Connecticut on this 11th day of February
2000.

                                              ACCENT COLOR SCIENCES, INC.


                                              ----------------------------------
                                              By:  Charles E. Buchheit
                                              Title: President, Chief Executive
                                                     Officer and Director

          Pursuant  to the  requirements  of the  Securities  Act of  1933,  the
following persons have signed this registration  statement in the capacities and
on the dates indicated.



             Signature                          Title                                Date
             ---------                          -----                                ----

                                                                       

By:_______________________             President, Chief Executive            February 11, 2000
Name:  Charles E. Buchheit           Officer and Chief Financial
                                               Officer

By:_______________________*             Vice Chairman and Chief              February 11, 2000
Name:  Norman L. Milliard                 Technology Officer


By:_______________________*       Chairman of the Board of Directors         February 11, 2000
Name: Richard J. Coburn


By:_______________________*                   Director                       February 11, 2000
Name: Joseph T. Brophy


By:_______________________*                   Director                       February 11, 2000
Name: Richard Hodgson


                                      -26-




             Signature                          Title                                Date
             ---------                          -----                                ----

                                                                       


By:_______________________*            Secretary and Director                February 11, 2000
Name: Willard F. Pinney, Jr.


By:_______________________*                   Director                       February 11, 2000
Name: Robert H. Steele



* Signature by Charles E. Buchheit, attorney-in-fact

                                      -27-