EXHIBIT 4.5 OUTSTANDING RIGHTS TO PURCHASE INTEGRA SHARES (AS OF SEPTEMBER 18, 2000) SECURITY COMMON STOCK ISSUABLE ON CONVERSION OR EXERCISE Employee Stock Options 3,706,743* Warrants 550,811+ Conv. Preferred Stock Series A 250,000 Series B 2,617,801 Series C 600,000 *Average exercise price per option is $6.37. Options generally carry a term of five or six years. +Average exercise price per warrant is $6.66.