KYTO BIOPHARMA, INC. C/O B TWELVE LIMITED 41A AVENUE ROAD, YORK SQUARE TORONTO, ONTARIO, M5R 2G3 PHONE (416) 955-0159 FAX (416) 364-1522 Wednesday, May 21, 2003 BY FAX AND EDGAR FILING ----------------------- United States Securities and Exchange Commission Division of Corporate Finance 450 Fifth Street, N.W. Washington, D.C. 20549 ATTN: SETH E. TOBIN Ref: Registration Statement Withdrawal --------------------------------- B. Twelve, Inc. (now known as "Kyto Biopharma, Inc.") Form SB-2 File No. 333-76944 Please, accept this letter as our application to withdraw our amended private offering Form SB-2 filed on August 21, 2002, according to rules reported at http://www.sec.gov/rules/final/33-7943.htm. Our Company does no longer require selling its common stock at present time and intends to register its securities (Form 10-SB) under the Exchange Act. In addition, I confirm that no securities were sold in connection with the offering under Form SB-2. This statement letter has been filed with Edgar. I hope the above statement is satisfactory. Yours truly, /s/ Jean-Luc Berger - --------------------------- Jean-Luc Berger, Ph.D. President & Chief Executive Officer