JEFFREY G. KLEIN, P.A. 2600 NORTH MILITARY TRAIL, SUITE 270 BOCA RATON, FLORIDA 33431 Telephone: (561)997-9920 Telefax: (561)241-4943 January 10, 2007 Mr. Jim B. Rosenberg Senior Assistant Chief Accountant Securities and Exchange Commission 100 F Street NE Washington, DC 20549 RE: Cybrdi, Inc. FILE NO. 000-09081 Dear Mr. Rosenberg: The following information is supplied in response to the Commission's letter dated September 26, 2006. All of these changes will be incorporated in an amended Form 10-K to be filed with the Commission as soon as the information is available. 1. Please provide the quarterly information required by Item 302 of Regulation S-K. The following table sets forth the quarterly financial information of the Company: FISCAL 2005 QUARTERLY PERIOD ENDED - ----------------------------------------- ----------------------------------------------------------- 3/31/2005 6/30/2005 9/30/2005 12/31/2005 Net revenues $358,329 $399,550 $315,000 $354,920 Gross profit 305,710 335,642 262,000 244,609 Net income 90,053 103,647 80,000 (268,572) Net income per common share: Basic & Diluted -- -- -- -- FISCAL 2004 QUARTERLY PERIOD ENDED - ----------------------------------------- ----------------------------------------------------------- 3/31/2004 6/30/2004 9/30/2004 12/31/2004 Net revenues 357,475 368,382 393,000 414,186 Gross profit 303,313 291,753 306,000 299,077 Net income 105,727 104,382 129,000 149,724 Net income per common share: Basic & Diluted -- -- -- -- The foregoing has been incorporated in Item 6, Selected Financial Information of the amended annual report. 2. Please provide a report that opines on the year ended December 31, 2003. We have included a report as executed by Weinberg & Co., the Company's independent auditing firm for the year ended December 31, 2003 and included their report in our amended Form 10-k. 3 Please clarify your disclosure that the amounts of weighted average shares outstanding had been "restated to show the recapitalization", as the amounts for 2003 and 2004 do not appear to include the shares in the reverse acquisition with Cybrdi Maryland that occurred in 2005. Please clarify for us why this is appropriate or restate your financial statements and related disclosures to include these shares in the 2003 and 2004 amounts. The amounts of weighted average shares outstanding for 2003 and 2004 has been restated to show the recapitalization transaction in 2005 for consistent presentation. 4. Please disclose how you accounted for the acquisition of an 80% interest of Chaoying Biotech. As you acquired it through the exchange of 99% of your shares to the existing shareholders of Chaoying Biotech, please address whether it was treated as a reverse acquisition. If you instead accounted for it as a business combination under SEAS 141, please provide the relevant disclosures required by its paragraphs 51 through 57. The acquisition was treated as a reverse acquisition and will include disclosure to show how the Company accounted for the acquisition. Chayoing Biotech is an 80% joint venture. 5. Please disclose your policy for recognizing the proceeds of government grants, including how you determine when you have satisfied any conditions of the grant and the period over which the proceeds should be recognized. The government grants were awards given to the Company that successfully completed certain product development projects and the grants were recognized as income upon receipts of the cash. 6. Please file the Forms 10-Q for the quarterly periods ended March 31 and June 30, 2006, file Forms 12b-25 for the Form 10-Q or tell us why you do not need to file these Forms. The Company filed its quarterly report on Form 10-QSB for the period ended March 31, 2006 with the Securities and Exchange Commission on October 19, 2006. With the filing of this quarterly report, the Registrant has chosen to become a small business filer. 2 The Company has filed both its quarterly reports for the periods ended June 30, and September 30, 2006 on December 20, 2006 and January 3, 2007 respectively. No Form 12b-25 was filed at the filing date for either of these reports as there was no reasonable expectation that the reports could be filed within any prescribed filing deadlines. This letter has been reviewed by the Company's officers and by Mr. Lieu. The Company acknowledges that: o The Company is responsible for the adequacy and accuracy of the disclosure in the filings. o The Company acknowledges that staff comments or changes to disclosure in response to staff comments do not foreclose the Commission from taking any action with respect the filings; and o The Company may not assert staff comments as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States. Please be assured that the Company will continue to provide additional information as requested. Sincerely, Jeffrey G. Klein