Exhibit 10.46(1)


                                                                           Final


                  AMENDED AND RESTATED EMPLOYMENT AGREEMENT

            This Amended and Restated  Employment  Agreement (the  "Agreement"),
effective as of the 1st day of March,  2007,  between  Immtech  Pharmaceuticals,
Inc.,  a Delaware  corporation  (the  "Company"),  and Mr.  Eric L.  Sorkin,  an
individual residing in Montclair, New Jersey (the "Executive").

                              W I T N E S S E T H:

            WHEREAS,  the Company desires to continue to employ the Executive as
President  and  Chief  Executive  Officer  of the  Company  upon the  terms  and
conditions set forth herein; and

            WHEREAS,  Executive is willing to continue such  employment upon the
terms and conditions set forth herein;

            NOW  THEREFORE,   in  consideration  of  the  mutual  covenants  and
agreements  contained herein,  the parties agree as follows:

            Section 1.  Duties.  The  Company  agrees  that  Executive  shall be
employed by the  Company  during the Term (as defined  below) as  President  and
Chief Executive Officer of the Company.  Executive shall perform such duties and
shall have such responsibilities  consistent with the Bylaws of the Company, the
Company's polices for senior executive officers and customary for the duties and
position of his office,  in each instance  subject to the direction of the Board
of  Directors.  Executive  agrees to be so  employed  and shall  devote his best
efforts to advance the interests of the Company.

            Section 2. Term.  Subject to Sections 4, 5 and 6 hereof, the term of
the  Executive's  employment  hereunder  (the  "Term")  shall  be  for a  period
commencing  on January 30, 2006 (the  "Effective  Date") to March 31, 2007,  and
thereafter  shall  automatically  renew for  successive  one year periods unless
notice of  non-renewal  is given by either  party not less than 30 days prior to
each successive anniversary date of this Agreement while Executive is employed.

            Section 3. Compensation.

            (a) Base  Salary.  During  the  Term,  beginning  on April 1,  2007,
Executive  shall be paid at a per annum rate of $375,000  ("Base  Salary").  The
Base Salary shall be payable by the Company to Executive in accordance  with the
Company's regular payroll practices for senior management.

            (b) Stock  Options.  Executive  shall be eligible  for stock  option
grants  ("Options")  under  the  Company's  2000  Stock  Incentive  Plan  or any
successor  thereto  (collectively,   the  "Incentive  Plan")  as  determined  by
Executive and the  Compensation  Committee  (the  "Committee")  of the Company's
Board of Directors or the Committee and the






other  independent  directors  of the  Company  (as  directed  by the  Board  of
Directors).  All such Options shall be evidenced by stock option  agreements and
shall contain the following  terms:  (i) the exercise price shall equal the fair
market value of the underlying shares of the Company's common stock on the grant
date,  (ii) the term  shall be ten years,  (iii) the Option  shall be subject to
settlement on a net share basis (to enable Executive to make a cashless exercise
and payment of minimum statutory tax  liabilities),  (iv) the Option shall be an
incentive stock option to the extent  possible,  and (v) the Option shall remain
exercisable for the full term,  whether or not Executive  remains  employed with
the Company.

            (c)  Bonuses.  Executive  shall be  eligible  to  receive  an annual
performance  bonus in cash of up to 60% of the  Base  Salary  for  each  year of
employment hereunder,  beginning with the fiscal year ending March 31, 2008. Any
such bonus shall be  determined  in the sole  discretion of the Committee or the
Committee and the other independent directors of the Company (as directed by the
Board  of  Directors)  based  on  certain  milestones  determined  in  the  sole
discretion of the Committee or the Committee and the other independent directors
of the Company (as directed by the Board of Directors).  Any bonus due Executive
under this Section 3(c) shall be payable by the Company to Executive  within 120
days after end of the Company's applicable fiscal year.

            (d) Vacation,  Sick Leave and Holidays.  During the Term,  Executive
shall be entitled  to 20 days paid  vacation  on an annual  basis,  and shall be
entitled to sick leave and holidays at full pay  (beginning on April 1, 2007) in
accordance  with the Company's  policies  established and in effect from time to
time.

            (e) Welfare Benefits.  During the Term,  Executive shall be entitled
to participate  in all insurance,  retirement,  employee  benefits,  pension and
profit-sharing  plans and  other  fringe  benefit  programs  established  by the
Company, including health insurance (collectively, "Welfare Benefits").

            (f) Reimbursement of Expenses.  During the Term,  Executive shall be
reimbursed for all items of travel and entertainment and miscellaneous  expenses
reasonably  incurred  by him on behalf of the  Company.  Executive  shall,  as a
condition of such reimbursement, provide sufficient documentation in such detail
as will allow  Company to deduct such  expenses.  Reimbursement  of expenses not
claimed within sixty (60) days after  incurred  shall be deemed waived,  and all
reimbursement  payments for a particular  calendar year shall be paid within two
and one half months after the end thereof.

            (g) Severance.  Upon termination of Executive's employment hereunder
by the Company  without Cause (as defined below),  including  non-renewal of the
Agreement by the  Company,  or by  Executive  for Good Reason (as defined  below
(other than  pursuant to Section 4 or 5 below),  the Company will pay or provide
to the Executive (the following, collectively,  "Severance"): (1) salary, at the
greater of (i) $375,000 and (ii)  Executive's  Base Salary rate in effect on the
date of  termination,  equal to six months,  payable in  accordance  with normal
payroll  practices  applicable to the Company's senior  executives,  (2) Welfare
Benefits and insurance in which  Executive  was a  participant  or which covered
Executive  on the date of  termination  (less any  amounts  Executive  is paying
immediately prior to such termination to participate in such Welfare Benefits or
insurance) for the twelve month period following any such termination (or,


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at the Company's option, the Company may provide to Executive after-tax payments
to purchase  equivalent  benefits),  (3) a cash bonus, on the date on which such
bonus would  otherwise be due under Section 3(c) hereof,  equivalent to the cash
bonus  amount to which  Executive  would  have been  entitled  had he  continued
working until the end of the then current Term and (4) immediate  vesting of all
outstanding  options  then held by  Executive,  and the right to  exercise  such
options for the remainder of their respective  terms. The Severance shall be the
sole payment and shall satisfy all obligations of the Company and its affiliates
to Executive in the event of any such termination of Executive's  employment and
shall be contingent on Executive's  execution of the Company's  standard release
and waiver agreement. To the extent the value of the Severance paid to Executive
under  clauses  (1)  through  (4) of this  Agreement  is equal  to or less  than
Executive's  annualized  Base  Salary  as of the  date of his  termination,  the
Severance  is  being  paid  to  Executive  in   consideration   for  Executive's
non-competition covenant set forth in Section 13 hereof.

            (h)  Insurance.   During  the  Term,   subject  to  insurability  of
Executive,  the Company shall provide Executive with disability  insurance in an
amount not less than  $375,000  or  Executive's  Base Salary then in effect that
would have been payable pursuant to the terms of this Agreement.

            Section 4. Death or Total Disability of Executive.

            (a) Death.  In the event of the death of Executive  during the Term,
this Agreement shall terminate effective as of the date of the Executive's death
and the Company shall have no further obligations or liability hereunder, except
the Company shall pay or provide to the Executive's  estate (i) twelve months of
the  Executive's  then current  Base Salary or $375,000 if not then  receiving a
Base Salary (payable in accordance with the Company's  normal payroll  practices
for senior management) and a pro rata share of the cash bonus under Section 3(c)
for the period up to the date of  termination,  (ii) all amounts due pursuant to
the Welfare  Benefits and  insurance in which  Executive  was a  participant  or
covered and (iii)  immediate  vesting of all options then held by Executive  and
the right to exercise  the options  through the  remainder  of their  respective
terms.

            (b)  Total  Disability.  In the event of the  Total  Disability  (as
hereinafter  defined) of Executive for a period of 120  consecutive  days during
the Term, the Company shall have the right to terminate  Executive's  employment
hereunder by giving  Executive ten (10) days' written notice  thereof,  and upon
expiration  of such ten (10) day  period,  the  Company  shall  have no  further
obligations or liability under this  Agreement,  except the Company shall pay or
provide to Executive (i) twelve months of  Executive's  then current Base Salary
or  $375,000  if not  then  receiving  a Base  Salary  (payable,  to the  extent
available,  from the proceeds of the disability  insurance  described in Section
3(h)  hereof,  and  when  salary  payments  are  made to  other  Company  senior
executives  during the applicable term following  Executive's  Total Disability)
and a pro rata share of the cash bonus under  Section  3(c) for the period up to
Executive's date of Total Disability,  (ii) Welfare Benefits and/or insurance in
which Executive is a participant or which covered Executive on the date of Total
Disability  (without  deduction for any amounts Executive was paying immediately
prior  to  such  determination  to  participate  in  said  Welfare  Benefits  or
insurance) for the twelve month period  following the date of  determination  of
Total  Disability  (or,  at the  Company's  option,  the  Company may provide to
Executive  after-

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tax payments to purchase equivalent benefits) and (iii) immediate vesting of all
options  then held by Executive  and the right to exercise  such options for the
remainder of their respective terms.

            The term "Total Disability",  when used herein,  shall mean a mental
or physical condition which, based upon competent medical evidence,  renders the
Executive unable or incompetent to carry out  substantially  all of the material
job responsibilities he held or tasks to which he was assigned, to be determined
in the sole discretion of the Company's Board of Directors.

            Section  5.   Discharge   for  Cause.   The  Company  may  terminate
Executive's  employment hereunder for the following reasons (each of which shall
constitute  "Cause");  (a)  habitual  intoxication;   (b)  drug  addiction;  (c)
conviction of Executive of a felony (d) a unanimous  vote of  non-confidence  by
the  Board of  Directors  (excluding  executive),  or (e) a  material  breach by
Executive  of any term or provision  of this  Agreement or any Company  policies
applicable  to  Executive,  which  Executive  fails to cure within 30 days after
receipt of written  notice from the Company  advising  Executive,  in reasonable
detail,  of the  breach.  In the event  that the  Company  shall  discharge  the
Executive  pursuant  to this  Section  5,  the  Company  shall  have no  further
obligations or liability under this  Agreement,  except the Company shall pay to
Executive the portion,  if any, of  Executive's  Base Salary earned  through the
date employment terminates.

            Section 6.  Discharge  Without Cause;  Good Reason.  The Company may
terminate Executive's  employment  hereunder,  for any or no reason, at any time
upon at least thirty (30) days' prior written notice to Executive. Executive may
resign  upon  thirty  days'  notice for "Good  Reason"  which  shall be deemed a
termination  without Cause if not cured within said 30 day notice period. In the
event of a discharge by the Company  without Cause or  resignation  by Executive
for Good Reason (provided that Executive's  resignation occurs within six months
of the event  constituting  Good Reason,  Executive shall be entitled to receive
the  applicable  Severance  provided for in Section 3 hereof.  In the event of a
Change in Control  Event,  whether or not Executive  terminates  his  employment
hereunder,  all  outstanding  stock  options  then  held by  Executive  shall be
immediately  and fully vested.  "Good Reason" means (i) breach by the Company of
any of the  material  terms and  conditions  of this  Agreement  or any  Company
policies applicable to Executive,  (ii) relocating Executive,  without his prior
consent,  outside of the Chicago,  IL or New York, NY metropolitan  areas, (iii)
assignment of duties that are  significantly  different,  whether  diminution or
promotion,  without Executive's consent, (iv) any reduction of Base Pay, Welfare
Benefits or Bonus unless applied uniformly to all Company  executives,  or (v) a
Change in  Control  Event.  A "Change in  Control  Event"  shall mean any of the
following:  (i) any  person or entity  (except  for a  current  stockholder)  or
"group" (as contemplated by Section  13(d)(3) of the Securities  Exchange Act of
1934) becomes the beneficial  owner of greater than 50% of the then  outstanding
voting power of the Company;  (ii) a merger or consolidation with another entity
where the voting securities of the Company  outstanding  immediately  before the
transaction  constitute  less than a majority of the voting  power of the voting
securities of the Company or the surviving entity outstanding  immediately after
the transaction;  (iii) the sale or disposition of all or  substantially  all of
the Company's  assets; or (iv) the stockholders of the Company approve a plan or
proposal for liquidation or dissolution of the Company.



                                      -4-




            Section 7.  Supersedes  Other  Agreements;  Entire  Agreement.  This
Agreement supersedes and is in lieu of any and all other employment arrangements
between  Executive  and the  Company.  This  Agreement  constitutes  the  entire
agreement of the parties hereto and supersedes all prior contracts or agreements
with respect to the subject matter herein, whether oral or written.

            Section 8.  Amendments.  Any Amendment to this Agreement,  excluding
any extension or renewal of the Term, shall be made in writing and signed by the
parties hereto.

            Section 9. Enforceability.  If any provision of this Agreement shall
be held invalid or unenforceable, in whole or in part, then such provision shall
be deemed to be modified or restricted to the extent and in the manner necessary
to render the same valid and  enforceable,  or shall be deemed excised from this
Agreement as the case may require,  and this  Agreement  shall be construed  and
enforced to the maximum  extent  permitted by law, as if such provision had been
originally  incorporated  herein as so  modified  or  restricted,  or as if such
provision had not been originally incorporated herein, as the case may be.

            Section 10. Governing Law. The validity and effect of this Agreement
shall be governed  exclusively  by the laws of the State of New York,  excluding
the "conflicts of laws" rules of that state.

            Section 11. Assignment.  This Agreement and the obligations  created
hereunder may not be assigned by the Company  without the prior written  consent
of Executive.  This Agreement and the obligations  created  hereunder may not be
assigned by the Executive.

            Section 12. Notices.  All notices  required or permitted to be given
hereunder  shall be in  writing  and shall be deemed  to have  been  given  when
personally  delivered or mailed, by certified or registered mail, return receipt
requested, addressed to the intended recipient as follows:

            If to Executive:

                  Eric L. Sorkin
                  c/o Immtech Pharmaceuticals, Inc.
                  One North End Avenue
                  New York, New York  10282

            If to the Company:

                  Immtech Pharmaceuticals, Inc.
                  150 Fairway Drive, Suite 150
                  Vernon Hills, Illinois 60061
                  Attention:  Secretary

            Any party may from time to time change its address for the  purposes
of notices to that party by a similar  notice  specifying a new address,  but no
such change shall be deemed to have been given until it is actually  received by
the party sought to be charged with its  contents.






            Section 13. Covenant Not to Compete.  Executive  agrees that he will
not, either  directly or indirectly,  at any time during his employment with the
Company,  compete or interfere,  or setup to compete or interfere, or aid others
to so compete or interfere or set up to compete or interfere with the Company in
the conduct or  transaction  of any business or  enterprise in which the Company
(i) is  presently  engaged,  or (ii) is planning to become  engaged and has made
significant  monetary  investment in order to be engaged, or (iii) is engaged at
any time during Executive's employment by the Company.

            Executive   further  agrees  that,   upon  any  termination  of  his
employment  with the  Company,  he will not,  for a period of twelve (12) months
from the date of termination (the "Restriction  Period"),  within any geographic
markets where the Company is then active,  directly or  indirectly  compete with
the  Company  by  engaging  in a  competitive  business,  as an owner,  partner,
officer, director, associate, employee,  consultant,  salesperson or stockholder
or aid others,  directly or indirectly,  in competing with the Company.  For the
purposes  of  this  Agreement,  competition  and/or  engaging  in a  competitive
business  shall  include,  but  shall  not be  limited  to,  any  disclosure  of
confidential,  proprietary, promotional or marketing information, trade secrets,
names of the Company's  employees or research  consultants,  names of suppliers,
names of customers or any other  information  acquired  prior to  termination of
employment which is not already in the public domain.

            Executive  expressly  agrees that, upon a breach or violation of the
provisions  of this section,  the Company shall be entitled,  in addition to all
other remedies available to it, to appropriate  injunctive relief, without bond,
in any court of competent jurisdiction.

            Section 14. Confidentiality and Non-Disclosure.  Executive covenants
and agrees:

            (a) Not to use, publish or otherwise disclose,  except in the course
of his  duties as  Executive  of the  Company,  any  confidential,  proprietary,
patentable or copyrightable  information or materials  generated by or disclosed
to him in the course of his duties as an  employee  of the  Company,  except for
data which:

                        (i) Is or through no fault of the  Executive  comes into
            the public domain;

                        (ii)  After  the time of  disclosure  to  Executive,  is
            published or becomes a part of the public domain through no fault of
            Executive; or

                        (iii) Was in the  possession  of Executive  prior to the
            time of  disclosure  by the Company,  which can be  demonstrated  by
            Executive's written records or other competent evidence.

            (b) Not to disclose or utilize,  other than in  connection  with the
performance of his duties as an employee of the Company,  any  information  that
Executive is under a duty not to disclose.

            (c) Upon termination of his employment with the Company, to promptly
return to the  Company all written  and other  information,  data and  materials
which are  secret or


                                      -6-




confidential  in  nature  of  which  relate  to  patentable,   copyrightable  or
proprietary information relating to the business of the Company.

            Section  15.  Waiver.  No claim or right  arising out of a breach or
default  under this  Agreement can be discharged in whole or in part by a waiver
of that claim or right unless the waiver is supported by consideration and is in
writing and executed by the aggrieved party hereto or its or his duly authorized
agent.  A waiver by any party  hereto of a breach of default by the other  party
hereto of any  provision of this  Agreement  shall not be deemed a waiver of any
prior or subsequent compliance herewith, and such provision shall remain in full
force and effect.

            Section 16.  Taxes and Code  Section  409A  Over-ride.  Executive is
solely responsible for the payment of any tax liability (including any taxes and
penalties  arising  under  Section  409A of the Code) that may  result  from any
payments or benefits that he receives  pursuant to this  Agreement.  The Company
shall not have any obligation to pay,  mitigate,  or protect  Executive from any
such tax liabilities.  Nevertheless,  if the Company reasonably  determines that
Executive's  receipt of payments  or benefits  pursuant to Section 5 above would
cause him to incur  liability for additional tax under Section 409A of the Code,
then the Company may in its  discretion  suspend such payments or benefits until
the end of the six-month period following termination of Executive's  employment
(the "409A Suspension Period"). As soon as reasonably practical after the end of
the 409A Suspension  Period,  the Company will make a lump sum payment to me, in
cash,  in an amount equal to any payments and benefits that the Company does not
make during the 409A Suspension Period.  Thereafter,  Executive will receive any
remaining payments and benefits due pursuant to Section 5 in accordance with the
terms of that Section (as if there had not been any suspension beforehand).



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            IN WITNESS WHEREOF,  this Employment  Agreement has been executed by
the Company,  by a duly authorized member of the Board of Directors,  and by the
Executive on the date first above written.

                                       IMMTECH PHARMACEUTICALS, INC.



                                       By:/s/ Gary C. Parks
                                          ------------------------------------
                                          Chief Financial Officer


                                          /s/ Eric L. Sorkin
                                          ------------------------------------
                                          Eric L. Sorkin