Exhibit 32.1


                        CERTIFICATION OF PERIODIC REPORT


I, John G. Baust, Chief Executive Officer and Chief Financial Officer of Biolife
Solutions, Inc. (the "Company"), certify, pursuant to Section 906 of the
Sarbanes-Oxley Act of 2002, 18 U.S.C. Section 1350, that:

     1.   the Quarterly Report on Form 10-QSB of the Company for the quarterly
          period ended March 31, 2005 (the "Report") fully complies with the
          requirements of Section 13(a) or 15(d) of the Securities Exchange Act
          of 1934 (15 U.S.C. 78m or 78o(d)); and

     2.   the information contained in the Report fairly presents, in all
          material respects, the financial condition and results of operations
          of the Company.

Dated:   May 14, 2005


/s/ John G. Baust
- ---------------------------
John G. Baust, PhD
Chief Executive Officer and
Chief Financial Officer


A signed original of this written statement required by Section 906 of the
Sarbanes-Oxley Act of 2002 has been provided to the Company and will be retained
by the Company and furnished to the Securities and Exchange Commission or its
staff upon request.





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