POWER OF ATTORNEY
September 12, 2021

      	The undersigned hereby constitutes and appoints each of Alane P. Barnes,
Michael L. Jones, and Jessica L. Dickerson, the Chief Legal Officer, the
Executive Director, Finance & Principal Accounting Officer, and the Securities
Counsel, respectively, of BioCryst Pharmaceuticals, Inc. (the ?Company?),
signing singly and not jointly, with full power of substitution, as the
undersigned?s true and lawful attorney-in-fact to:

(1)	prepare, execute in the undersigned's name and on the undersigned?s
behalf, and submit to the U.S. Securities and Exchange Commission (the ?SEC?)
a Form ID, including amendments thereto (the ?Form ID?), and any other
documents necessary or appropriate to obtain codes and passwords enabling the
undersigned to make electronic filings with the SEC of reports required by the
Securities Exchange Act of 1934, as amended (the ?Exchange Act?), or any rule
or regulation of the SEC;

(2)	prepare, execute in the undersigned?s name and on the undersigned?s
behalf, and submit to the SEC, any and all Forms 3, 4, and 5 (the
?Section 16 Filings?), including amendments thereto, required to be filed
under Section 16(a) of the Exchange Act and the rules thereunder with
respect to equity securities of the Company;

(3)	do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute such Form ID
and any Section 16 Filings and to file such Form ID and any Section 16
Filings with the SEC and any stock exchange or similar authority; and

(4)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney-in-fact, may be of
benefit to, in the best interest of, or legally required by, the
undersigned, it being understood that the documents executed by such
attorney-in-fact on behalf of the undersigned pursuant to this Power of
Attorney shall be in such form and shall contain such terms and
conditions as such attorney-in-fact may approve in such attorney-in-fact's
discretion.

      	The undersigned hereby grants to each such attorney-in-fact full
power and authority to do and perform any and every act and thing
whatsoever requisite, necessary, or proper to be done in the exercise of
any of the rights and powers herein granted, as fully to all intents and
purposes as the undersigned might or could do if personally present, with
full power of substitution or revocation, hereby ratifying and confirming
that each such attorney-in-fact, or such attorney-in-fact's substitute or
substitutes, shall lawfully do or cause to be done by virtue of this
power of attorney and the rights and powers herein granted.  The
undersigned hereby authorizes, approves, and ratifies any and all prior
actions taken by such attorneys-in-fact in connection with the matters
contemplated herein. The undersigned acknowledges that such attorneys-in-
fact, in serving in such capacity at the request of the undersigned, do
not assume any of the undersigned's responsibilities to comply with the
Exchange Act or any rule or regulation of the SEC.

      	This Power of Attorney shall remain in full force and effect until
the undersigned is no longer required to file a Form ID, any Section 16
Filings, or any amendments or changes thereto, with respect to the
undersigned?s holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing
delivered to the foregoing attorneys-in-fact.

      	IN WITNESS WHEREOF, the undersigned has caused this Power of
Attorney to be executed as of the date first written above.




By:  /s/ Amy E McKee
Name:   Amy E McKee