UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: 3/31/2013 Check here if Amendment []; Amendment Number: ------- This Amendment (Check only one.): [] is a restatement. [] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: Ayer Capital Management, LP Address: 230 California Street, Suite 600 San Francisco, CA 94111 Form 13F File Number: The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this submission. Persons Signing this Report on Behalf of Reporting Manager: Name: Jay Venkatesan Title: Managing Member Phone: 415-874-4800 Signature, Place, and Date of Signing: /s/ Jay Venkatesan San Francisco, CA 5/15/2013 --------------------------------- --------------------------------- ---------- [Signature] [City, State] [Date] Report Type (Check only one): [X] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.) [ ] 13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).) [ ] 13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).) List of Other Managers Reporting for this Manager: Form 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 2 Form 13F Information Table Entry Total: 24 Form 13F Information Table Value Total: $ 117,997 -------------- (In Thousands) List of Other Included Managers: Provide a numbered list of the name(s) and 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report. No. Form 13F File Number Name 1 ACM Capital Partners, LLC ---- -------------------- ---------------------------------------------------- 2 Jay Venkatesan ---- -------------------- ---------------------------------------------------- FORM 13F INFORMATION TABLE COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8 ---------------------------- ---------------- --------- -------- ------------------ ---------- -------- --------------------- VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGERS SOLE SHARED NONE ---------------------------- ---------------- --------- -------- --------- --- ---- ---------- -------- --------- ------ ---- ACCURAY INC COM 004397105 2,705 583,044 SH DEFINED 1,2 583,044 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 5,284 292,106 SH DEFINED 1,2 292,106 0 0 ARTHROCARE CORP COM 043136100 11,584 333,250 SH DEFINED 1,2 333,250 0 0 BIOLINERX LTD SPONSORED ADR 09071M106 466 277,604 SH DEFINED 1,2 277,604 0 0 BOSTON SCIENTIFIC CORP COM 101137107 6,663 853,147 SH DEFINED 1,2 853,147 0 0 CARDINAL HEALTH INC COM 14149Y108 6,201 148,989 SH DEFINED 1,2 148,989 0 0 CHEMOCENTRYX INC COM 16383L106 1,781 128,838 SH DEFINED 1,2 128,838 0 0 CELGENE CORP RIGHT 12/31/2030 151020112 13,259 1,875,422 SH DEFINED 1,2 1,875,422 0 0 CVS CAREMARK CORPORATION COM 126650100 5,215 94,844 SH DEFINED 1,2 94,844 0 0 CYCLACEL PHARMACEUTICALS INC COM 23254L108 1,233 220,593 SH DEFINED 1,2 220,593 0 0 ENDOLOGIX INC COM 29266S106 9,818 607,930 SH DEFINED 1,2 607,930 0 0 EXPRESS SCRIPTS HLDG CO COM 30219G108 4,591 79,629 SH DEFINED 1,2 79,629 0 0 GILEAD SCIENCES INC COM 375558103 1,528 31,226 SH DEFINED 1,2 31,226 0 0 GRIFOLS S A SPONSORED ADR 398438309 14,111 486,431 SH DEFINED 1,2 486,431 0 0 HOLOGIC INC COM 436440101 7,546 333,879 SH DEFINED 1,2 333,879 0 0 INSMED INC COM PAR $.01 457669307 2,081 277,781 SH DEFINED 1,2 277,781 0 0 MCKESSON CORP COM 58155Q103 5,102 47,259 SH DEFINED 1,2 47,259 0 0 ORTHOFIX INTL N V COM N6748L102 219 6,100 SH DEFINED 1,2 6,100 0 0 PEREGRINE PHARMACEUTICALS IN COM NEW 713661304 938 699,935 SH DEFINED 1,2 699,935 0 0 PEREGRINE PHARMACEUTICALS IN CALL 713661904 3,350 2,500,000 CALL DEFINED 1,2 2,500,000 0 0 SHANGPHARMA CORP SPONSORED ADR 81943P104 2,278 254,477 SH DEFINED 1,2 254,477 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 5,979 150,690 SH DEFINED 1,2 150,690 0 0 THRESHOLD PHARMACEUTICAL INC COM NEW 885807206 675 146,321 SH DEFINED 1,2 146,321 0 0 UNIVERSAL HLTH SVCS INC CL B 913903100 5,390 84,392 SH DEFINED 1,2 84,392 0 0