EXHIBIT 4.1

                    STOCK OPTION PLAN AND OFFERING NOTICE AS
                     AMENDED AND RESTATED ON JANUARY 9, 2002







                                AXCAN PHARMA INC.

                                STOCK OPTION PLAN

                                       AND

                                 OFFERING NOTICE

                   AS AMENDED AND RESTATED ON JANUARY 9, 2002

1.       PURPOSE OF THE PLAN

1.1          The purpose of this stock  option  plan (the  "Plan") is to provide
directors,  senior  executives,  Consultants  and  full-time  employees of Axcan
Pharma Inc. ("Axcan") and its subsidiaries (Axcan and its subsidiaries,  present
and future,  being hereinafter  referred to collectively as the  "Corporations")
with a proprietary  interest  through the granting of options to purchase shares
of Axcan,  subject to  certain  conditions  as  hereinafter  set forth,  for the
following purposes:

1.1.1    to  increase  the  interest  in  the  Corporations'  welfare  of  those
         directors,  senior  executives,  Consultants  and  employees  who share
         primary responsibility for the management, growth and protection of the
         business of the Corporations;

1.1.2    to  furnish  an  incentive  to  such  directors,   senior   executives,
         Consultants   and   employees  to  continue   their   services  or  the
         Corporations; and

1.1.3    to provide a means through which each of the  Corporations  may attract
         able persons to enter its employment.

1.2      For the purposes of the Plan:

1.2.1    the term  "Consultant"  means any person or company  engaged to provide
         ongoing management or consulting services for the Corporations;

1.2.2    the term "Other Plans" means any stock option, stock option plan, stock
         purchase  plan  or  any  other  compensation  or  incentive   mechanism
         involving  the issuance or potential  issuance of shares to one or more
         directors,  senior  executives,  Consultants  or  full-time  employees,
         including a share purchase from treasury which is financially  assisted
         by any of the Corporations by way of a loan,  guaranty or otherwise and
         including  without  limitation  Axcan's Share  Purchase Plan adopted on
         December  15,  1995 and Axcan's  Stock  Participation  Plan  adopted on
         December 15, 1995;

1.2.3    the term "Outside Director" means a director of any of the Corporations
         who is not an employee of any of the  Corporations  and a director  who
         has ceased to be an employee of any of the  Corporations as at and from
         the date of such termination; and



1.2.4    a "Subsidiary of Axcan" shall be any corporation  (other than Axcan) in
         an unbroken chain of corporations  beginning with Axcan if, at the time
         of the granting of the option hereunder, each of the corporations other
         than the last  corporation  in the unbroken  chain owns shares to which
         are attached  more than fifty  percent  (50%) of the  aggregate  voting
         rights  attached  to  all  classes  of  shares  in  one  of  the  other
         corporations in such chain.

2.       ADMINISTRATION OF THE PLAN

2.1          The Plan shall be  administered  by the Board of Directors of Axcan
(the "Board").  The Board may delegate the general administration of the Plan to
any  committee  of the  Board,  in which  case,  unless  the  context  otherwise
requires, all references herein to the Board shall be deemed to be references to
such committee.

2.2          The Board may, from time to time, as it may deem expedient,  adopt,
amend and rescind  rules and  regulations  for carrying out the  provisions  and
purposes of the Plan. The  interpretation,  construction  and application of the
Plan and any provisions thereof made by the Board, shall be final and binding on
all holders of options granted under the Plan and all persons eligible under the
provisions of the Plan to participate  therein.  No member of the Board shall be
liable for any action taken or for any  determination  made in good faith in the
administration, interpretation, construction or application of the Plan.

3.       GRANTING OF OPTIONS

3.1      The  Board  may,  from  time  to  time,  designate  directors,   senior
         executives,  Consultants and full-time employees of the Corporations to
         whom options to purchase  common  shares in the share  capital of Axcan
         (the "Common Shares") may be granted and the number of Common Shares to
         be optioned to each, provided that:

3.1.1    the total number of Common Shares to be optioned to any one  individual
         under the Plan,  when  combined with the number of Common Shares issued
         or issuable to such individual under any of the Other Plans,  shall not
         exceed five  percent (5%) of the total  issued and  outstanding  Common
         Shares as of the date of grant of the option;

3.1.2    the total number of Common  Shares to be optioned  under the Plan shall
         not exceed the number provided in section 4.1 hereof;

3.1.3    the total  number of Common  Shares  reserved  for issuance to insiders
         ("Insiders"  as  defined  in the  Securities  Act  (Quebec))  and their
         associates  ("Associates"  as defined in the  Securities  Act (Quebec))
         under the Plan or any of the Other  Plans  shall not exceed ten percent
         (10%) of the Common Shares  outstanding  on the date of  reservation of
         such Common Shares;

3.1.4    the total  number of Common  Shares  issued to all  Insiders  and their
         Associates  under the Plan or Other  Plans  within a  one-year  period,
         shall not exceed ten percent (10%) of the Common Shares  outstanding on
         the date of issuance of such Common Shares; and

3.1.5    the total  number of Common  Shares  issued to any one  Insider and his
         Associates under the Plan or Other Plans within a one-year period shall
         not exceed five percent (5%) of the Common  Shares  outstanding  on the
         date of issuance of such Common Shares.

For the purposes of subsections 3.1.3, 3.1.4 and 3.1.5: (i) an entitlement
granted prior to the optionee becoming an Insider or Associate of an Insider
shall be excluded in determining the number of shares issuable to Insiders and
their Associates and (ii) no person shall be considered an Insider solely by
virtue of being a director or senior executive of a Subsidiary of Axcan.

3.2          Provided they may be granted in accordance  with the  provisions of
section 3.1 above,  options to Outside Directors to purchase Common Shares shall
be granted as follows:



3.2.1    A one-time option to purchase  twenty  thousand  (20,000) Common Shares
         shall  be  granted  to an  Outside  Director  on the day  such  Outside
         Director  is first  elected or named to the Board;  provided,  however,
         that if such day is not a business day, the grant shall be effective on
         the first business day following such election or nomination  ("Initial
         Options").

3.2.2    On an annual basis,  on the date of an Outside  Director's  election or
         re-election pursuant to the shareholders meeting, an option to purchase
         seven  thousand five hundred  (7,500) Common Shares shall be granted to
         each such Outside Director ("Annual  Options").  Annual Options will be
         cancelled  on any given  year  should an Outside  Director  fail in the
         option of the Board acting fairly,  to reasonably  fulfil his duties as
         an Outside Director,  in such a case, the Annual Options granted to him
         for such year shall be cancelled forthwith as if never granted.

3.3          Options may only be granted by Axcan  pursuant to  decisions of the
Board.  No option  shall be granted to any person who is not a director,  senior
executive,  Consultant  or full-time  employee of any of the  Corporations.  For
United States federal income tax purposes,  options granted pursuant to the Plan
may be either Incentive Stock Options  ("Incentive  Stock Options")  meeting the
requirements of Section 422 of the United States Internal  Revenue Code of 1986,
as  amended  (the "U.S.  Tax  Code"),  or  non-statutory  options  which are not
intended to meet the requirements of U.S. Tax Code Section 422.

3.4          The granting of options  hereunder  and the  obligation of Axcan to
deliver its Common Shares  pursuant  hereto shall be subject to Axcan  obtaining
the approval of any competent authority which may be required in connection with
the granting of options hereunder or the authorization,  issuance or sale of the
optioned shares and, if required,  Axcan having  effectively listed the optioned
shares on any stock  exchange on which Common  Shares may then be listed.  Axcan
shall use its best efforts to obtain all  approvals  necessary to give effect to
this Plan.

4.       SHARES SUBJECT TO THE PLAN

4.1          The maximum number of Common Shares which may be optioned under the
Plan,  subject to the provisions of article 8 hereof,  shall be 4,500,000 Common
Shares.

4.2          The Common  Shares in respect of which  options  are not  exercised
before  their expiry shall be  available  for  subsequent  options to be granted
pursuant to the provisions hereof.

5.       OPTION PRICE

5.1          The option price per share for Common  Shares which are the subject
of any option shall be fixed by the Board when such option is granted. Except as
set forth in article 11, the option  price for said shares shall be the reported
closing price for Common Shares on any stock exchange on which Common Shares may
then be listed on the last  trading  day  before  the day on which the option is
granted, provided that:

5.1.1    if no sale is  reported  on any such stock  exchange  on that day,  the
         reported  closing  price  shall be deemed to be the mean of the highest
         bid and asked quotations, if any, for such shares on any stock exchange
         selected  by the Board on which the  Common  Shares  are listed on that
         date;

5.1.2    if the Common Shares are listed on more than one stock exchange and the
         closing  price  for such last  trading  day is not the same on all such
         exchanges,  the option price shall be the reported closing price on the
         exchange having recorded the highest volume of Common Shares traded for
         such day; and

5.1.3    prices and quotations  expressed in Canadian or U.S.  currency shall be
         converted in the other currency  based on the exchange rate  prevailing
         for the relevant  trading day as  published in the Wall Street  Journal
         (or  failing  its  publication,  in any  national  financial  newspaper
         published  in Canada or the  United  States as may be  selected  by the
         Board).



6.       CONDITIONS GOVERNING OPTIONS

6.1          Options  shall be evidenced  by a stock  option  agreement or other
written  instrument in such form not inconsistent with the Plan as the Board may
from time to time  determine,  provided  that the  substance of the following be
included or referenced therein:

6.1.1    Employment - The granting of an option to a director, senior executive,
         Consultant  or  full-time  employee  shall not  impose  upon any of the
         Corporations  any obligation to retain the optionee in its employ or to
         preserve the office of the optionee.

6.1.2    Option Term - The period  during which an option is  exercisable  shall
         not, subject to the provisions of the Plan,  exceed ten (10) years from
         the date the option is granted.

6.1.3    Exercise of Options - Prior to its expiration or earlier termination in
         accordance  with the Plan,  each option shall be  exercisable as to the
         whole or any portion thereof at the time or times stipulated. The Board
         may,  at  the  time  of  granting  a  particular  option,  impose  such
         conditions as it shall determine in its sole  discretion  regarding the
         time or times at which the option may be exercised in whole or in part.

6.1.4    Non-assignability  of  Options  -  Each  option  granted  hereunder  is
         personal to the optionee and shall not be assignable or transferable by
         the optionee,  whether  voluntarily  or by operation of law,  except by
         will or by the  laws of  succession  of the  domicile  of the  deceased
         optionee.  No option granted hereunder shall be pledged,  hypothecated,
         charged,  transferred,  assigned or otherwise encumbered or disposed of
         on pain of nullity, and, subject to the foregoing exception in the case
         of death,  each option  granted  hereunder may be exercised only by the
         optionee.

6.1.5    Effect of Termination of Office or Employment or of Death
         ---------------------------------------------------------

6.1.5.1               Upon an  optionee's  full-time  employment  or  consulting
                      services with the Corporations  being terminated for cause
                      or upon an  optionee  ceasing to be a  director  or senior
                      executive  of any of the  Corporations  by  reason  of his
                      being  removed  or  becoming  disqualified  from  being  a
                      director  or senior  executive  by law,  any option or the
                      unexercised portion thereof granted to him shall terminate
                      forthwith.

6.1.5.2               Upon an  optionee's  full-time  employment  or  consulting
                      services with the Corporations being terminated (except in
                      the case of  transfer  from  one  Corporation  to  another
                      Corporation  contemplated herein) otherwise than by reason
                      of death or  termination  for cause,  or upon an  optionee
                      ceasing to be a director (other than an Outside  Director)
                      or senior executive of any of the Corporations  other than
                      by reason of death,  removal or  disqualification  by law,
                      any option or unexercised  portion thereof granted to such
                      optionee  may be  exercised by him only for that number of
                      Common  Shares which he was entitled to acquire  under the
                      option  pursuant to subsection  6.1.3  hereinabove  at the
                      time of such  termination or cessation.  Such option shall
                      only be  exercisable  within  ninety  (90) days after such
                      termination or cessation or prior to the expiration of the
                      term of the option,  whichever occurs earlier.  Any option
                      or unexercised  portion thereof granted to an optionee who
                      is an Outside Director,  and who ceases to hold his office
                      for reason other than death,  removal or  disqualification
                      by law,  may be  exercised  within the time  period and in
                      accordance  with the other terms and  conditions  provided
                      for any such option.

6.1.5.3               If an optionee dies while employed on a full-time basis by
                      any of the  Corporations  or while  serving as a director,
                      Consultant or senior executive of any of the Corporations,
                      any option or unexercised  portion thereof granted to such
                      optionee may be exercised by a legatee or legatees of such
                      optionee under the optionee's last will or by his personal
                      representatives  for that number of Common Shares which he
                      was  entitled  to  acquire  under the option  pursuant  to
                      subsection  6.1.3  hereinabove  at the time of his demise.
                      Such option shall only be  exercisable  within twelve (12)
                      months  after  the  optionee's   death  or  prior  to  the
                      expiration  of the term of the  option,  whichever  occurs
                      earlier.



6.1.5.4               The  Board  may,  subject  to the  prior  approval  of The
                      Toronto  Stock  Exchange,  or  other  relevant  regulatory
                      authorities, at any time and at its discretion,  waive any
                      of the  termination  provisions  contained in  subsections
                      6.1.5.1,  6.1.5.2  and  6.1.5.3  hereof in  respect of any
                      particular optionee.

6.1.6    Rights as a Stockholder - The optionee (or his personal representatives
         or  legatees)  shall  have no rights  whatsoever  as a  shareholder  in
         respect of any shares  covered by his option until the date of issuance
         of a  share  certificate  to him (or his  personal  representatives  or
         legatees) for such shares.  Without in any way limiting the  generality
         of the  foregoing,  no adjustment  shall be made for dividends or other
         rights  for  which  the  record  date is prior to the date  such  share
         certificate is issued.

6.1.7    Method of Exercise - Subject to the  provisions  of the Plan, an option
         granted  under  the Plan  shall be  exercisable  (from  time to time as
         provided in subsection  6.1.3  hereinabove)  by the  optionee's (or his
         personal  representatives' or legatees') giving of notice in writing to
         Axcan  at its  registered  office,  addressed  to  its  Vice-President,
         Finance,  which  notice  shall  specify the number of Common  Shares in
         respect of which the option is being exercised and shall be accompanied
         by full payment, by cash or certified cheque, of the purchase price for
         the number of shares specified. On the date of issue of the certificate
         representing the shares purchased under the option,  which shall not be
         later than the tenth (10th)  business day following the date of receipt
         by the  Vice-President,  Finance of Axcan of the written  notice herein
         referred to, the optionee shall be considered as the registered  holder
         of  such   number  of  shares  as  the   optionee   (or  his   personal
         representatives  or  legatees)  shall  have  then  paid  for and as are
         specified in such notice and Axcan shall cause the  transfer  agent and
         registrar  of  Axcan  to  deliver  to the  optionee  (or  his  personal
         representatives  or  legatees),   according  to  the  latter's  written
         instructions,  if  any,  a  certificate  in the  name  of the  optionee
         representing  such shares.  If required by the Board by notification to
         the  optionee  at the time of  granting  of the  option,  it shall be a
         condition of such exercise that the optionee shall represent that he is
         purchasing  the  Common  Shares in respect of which the option is being
         exercised  for  investment  only  and  not  with a view  of  resale  or
         distribution.

7.       USE OF PROCEEDS

7.1      The  proceeds  received  by  Axcan  upon the  exercise  of  options  by
         optionees  shall be used to increase  the working  capital of Axcan and
         for general corporate purposes.

8.       ADJUSTMENT TO SHARES SUBJECT TO THE OPTION

8.1          In the  event  that the  outstanding  Common  Shares  of Axcan  are
hereafter  changed into or exchanged for a different number or kind of shares or
other securities of Axcan or of another Corporation,  or in the event that there
is a reorganization,  amalgamation,  consolidation,  reclassification,  dividend
payable in capital stock or other change in the capital stock of Axcan,  subject
to  regulatory  approval,  the Board  shall  make such  adjustments  as it deems
appropriate  in the number and kind of shares for the purchase of which  options
may be granted under the Plan and such adjustments shall be final and binding.

9.       AMENDMENT OR DISCONTINUANCE OF THE PLAN

9.1          The Board may amend,  subject to the prior  approval of The Toronto
Stock Exchange or other relevant regulatory authorities, or discontinue the Plan
or the  terms of any  options  granted  under  the Plan at any  time,  provided,
however,  that no such amendment may  detrimentally  alter any option previously
granted to an  optionee  under the Plan  without  the  consent of the  optionee,
except to the extent required by law.

9.2          Notwithstanding  anything contained to the contrary in this Plan or
in any resolution of the Board in implementation thereof:

9.2.1    in the event Axcan  proposes to amalgamate,  merge or consolidate  with
         any other  Corporation  (other than with a  wholly-owned  Subsidiary of
         Axcan) or to liquidate,  dissolve or wind-up,  or in the event an offer
         to purchase the Common  Shares or any part thereof shall be made to all
         holders of Common  Shares,  Axcan



         shall have the right,  upon  written  notice  thereof to each  optionee
         holding  options  under this Plan,  to permit the  exercise of all such
         options  within the thirty (30) day period next  following  the date of
         such notice and to determine  that upon the  expiration  of such thirty
         (30) day period, all rights of optionees to such options or to exercise
         same  (to the  extent  not  theretofore  exercised)  shall  ipso  facto
         terminate and cease to have any further force or effect whatsoever;

9.2.2    the Board may, by resolution,  advance the date on which any option may
         be  exercised,  in the manner to be set forth in such  resolution.  The
         Board  shall not,  in the event of any such  advancement,  be under any
         obligation  to advance the date upon which any option may be  exercised
         by any other optionee; and

9.2.3    the Board may,  by  resolution,  but subject to  applicable  regulatory
         provisions,  decide that any of the  provisions  hereof  concerning the
         effect  of  termination  of  the   optionee's   full-time   employment,
         consulting  services or  cessation of the  optionee's  office as senior
         executive or director shall not apply for any reason  acceptable to the
         Board.

10.      OTHER MATERIAL INFORMATION

10.1          Reference is made to the most recently  available  proxy material,
annual  information  form,  press  releases,  material change reports and annual
financial  statements of Axcan as regards  certain facts relating to Axcan which
may be material.

11.      INCENTIVE STOCK OPTIONS

11.1          Options  granted under the Plan which are intended to be Incentive
Stock  Options  may only be granted  before the 10th  anniversary  of the Plan's
effective  date (such  anniversary  being December 15, 2005) and only to persons
who are employees of the  Corporations on the date of grant and shall be subject
to the following additional terms and conditions:

11.1.1   Dollar  Limitation - To the extent that the aggregate fair market value
         of Common Shares for which  Incentive Stock Options are exercisable for
         the first time by an employee during any calendar year (under all plans
         of the Corporations, with fair market value being determined as of each
         Incentive Stock Option's date of grant) exceeds U.S. $100,000,  options
         designated as Incentive Stock Options shall be treated as non-qualified
         stock  options  for United  States  tax  purposes,  with later  granted
         options being treated as non-qualified stock options first; and

11.1.2   10%  Stockholder - If any employee to whom an Incentive Stock Option is
         to be  granted  under  the  Plan is at the  time of the  grant  of such
         Incentive  Stock Option the owner of stock  possessing more than 10% of
         the  total  combined  voting  power  of all  classes  of  stock  of the
         Corporations, then the following special provisions shall be applicable
         to the  Incentive  Stock  Option  granted to such  individual:  (i) the
         purchase  price per share of the Common Share subject to such Incentive
         Stock  Option  shall not be less than 110% of the fair market  value of
         one share of Common  Share at the time of  grant;  and (ii) the  option
         exercise period shall not exceed five years from the date of grant.

Except as modified by the preceding provisions of this article 11, all the
provisions of the Plan shall be applicable to Incentive Stock Options granted
hereunder.

12.      EFFECTIVE DATE OF PLAN

12.1          This Plan was (i) originally  adopted by the Board on December 15,
1995,  (ii)  amended  by the Board on  December  23,  1999 and  ratified  by the
Shareholders of Axcan on February 22, 2000,  (iii) re-amended as of December 19,
2000 and ratified by the  shareholders  of Axcan on February 19, 2001,  and (iv)
re-amended  as of January 9, 2002 and ratified by the  shareholders  of Axcan on
February 21,  2002.  Should  changes be required in this Plan by any  securities
commission  or other  governmental  body of any province of Canada to which this
Plan has been  submitted or by The Toronto Stock  Exchange or any other exchange
on which the Common  Shares may from time to time be listed,  such changes shall
be made in this Plan as are  necessary to conform with such requests and if




such changes are approved by the Board,  this Plan, as amended,  shall remain in
full force and effect in its  amended  form as of and from  December  15,  1995.
Axcan may, in its  discretion,  qualify  this Plan in  additional  jurisdictions
outside of Canada.  However,  unless and until Axcan  decides to so qualify this
Plan,  employees  residing  in such  other  jurisdictions  are not  eligible  to
participate in this Plan.

                                            By Order of the Board of Directors



                                            February 22, 2002






SECRETARY CERTIFICATION

The undersigned certifies that the Stock Option Plan restated and amended is a
true copy of the Plan as adopted and restated on January 9, 2002, and has not
been amended or revoked.

April 24, 2002

/s/ Francois Painchaud
Francois Paichaud
Secretary