UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12B-25

                           NOTIFICATION OF LATE FILING

(Check One): [  ] Form 10-K and Form 10-KSB  [  ] Form 20-F  [  ] Form 11-K  [X]
Form  10-Q  and  Form  10-QSB
[  ]  Form  N-SAR

For  Period  Ended:  March  31,  2003

[   ]  Transition  Report  on  Form  10-K

[   ]  Transition  Report  on  Form  20-F

[   ]  Transition  Report  on  Form  11-K

[   ]  Transition  Report  on  Form  10-Q

[   ]  Transition  Report  on  Form  N-SAR

For  the  Transition  Period  Ended:  _______________________

    NOTHING IN THIS FORM SHALL BE CONSTRUED TO IMPLY THAT THE COMMISSION HAS
                   VERIFIED ANY INFORMATION CONTAINED HEREIN.

If  the  notification relates to a portion of the filing checked above, identify
the  items(s)  to  which  the  notification  relates:


PART  I  -  REGISTRANT  INFORMATION

Calypte  Biomedical  Corporation
- --------------------------------
Full  Name  of  Registrant:

__________________________
Former  Name  if  Applicable

1265  Harbor  Bay  Parkway
- --------------------------
Address  of  Principal  Executive  Office  (Street  and  Number)

Alameda,  CA  94502
- -------------------
City,  State  and  Zip  Code


PART  II  -  RULES  12B-25(B)  AND  (C)

If  the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be  completed.  (Check  box  if  appropriate)

     (a)     The reasons described in reasonable detail in Part III of this form
could  not  be  eliminated  without  unreasonable  effort  or  expense;

     (b)     The subject annual report, semi-annual report, transition report on
Form  10-K, Form 20-F, 11-K, Form N-SAR, or portion thereof, will be filed on or
before  the  fifteenth  calendar  day  following the prescribed due date; or the
subject  quarterly  report or transition report on Form 10-Q, or portion thereof
will  be  filed on or before the fifth calendar day following the prescribed due
date;  and

     (c)     The  accountant's  statement  or  other  exhibit  required  by Rule
12b-25(c)  has  been  attached  if  applicable.



PART  III  -  NARRATIVE

State  below  in  reasonable  detail  the reasons why the Form 10-K, 11-K, 10-Q,
N-SAR,  or  the  transition report or portion thereof, could not be filed within
the  prescribed  time  period.

Calypte Biomedical Corporation (the "Registrant") is still awaiting
documentation in order to properly prepare a complete and accurate Form 10-Q.
The Registrant has been unable to receive this data in a timely manner without
unreasonable effort and expense. For the foregoing reasons, the Registrant
requires additional time in order to prepare and file its quarterly report on
Form 10-Q for the quarter ended March 31, 2003.  The Registrant anticipates that
it will have all necessary information required to complete and file its Form
10-Q within five (5) calendar days of the date hereof.


PART  IV  -  OTHER  INFORMATION

(1)     Name  and  telephone  number  of  person  to  contact  in regard to this
notification
     Joseph  A.  Baratta                212             750-9700
     -------------------                ---             --------
     (Name)                    (Area  Code)             (Telephone  Number)

(2)     Have  all  other  periodic reports required under Section 13 or 15(d) of
the  Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
of  1940  during  the  preceding  12  months or for such shorter period that the
registrant  was  required  to  file such report(s) been filed?  If answer is no,
identify  report(s).
     [X]  Yes  [  ]  No

(3)     Is  it  anticipated that any significant change in results of operations
from  the corresponding period for the last fiscal year will be reflected by the
earnings  statements to be included in the subject report or portion thereof?  [
X  ]Yes  [  ]  No

If  so,  attach  an  explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of  the  results  cannot  be  made.




Revenues for the first quarter of 2003 totaled $784,000, compared with
$1,159,000 for the comparable period in 2002. The net loss attributable to
common stockholders for the first quarter of 2003 was $6,374,000, or $0.04 per
common share, compared with a net loss attributable to common stockholders of
$678,000, or $0.02 per common share, for the three months ended March 31, 2002.
The net loss for the first quarter of 2003 included $3,587,000 in non-cash
charges that were related to the grants of common stock and options and warrants
as compensation for services and non-cash interest expense related primarily to
the accounting for Registrant's convertible debt financing instruments.  During
the quarter ended March 31, 2002, non-cash charges and credits were a net credit
of $1,292,000, related primarily to the gain on settlement of debt.

The change in revenue from the quarter ended March 31, 2002 as compared to the
quarter ended March 31, 2003 can be attributed in part to the announcement made
by the Registrant last fiscal year of its intention to wind down its operations.
In anticipation of the wind down last year, many of the Registrant's customers
in turn increased their order rates as a contingency in the event of a cessation
of Registrant's operations and non-availability of Registrant's products.  The
Company subsequently restarted its operations and the Registrant's post-restart
revenue for quarter ended March 31, 2003 did not reflect the
uncharacteristically higher order rate reflected in the March 31, 2002 revenues.



                          CALYPTE BIOMEDICAL CORPORATION
                         -------------------------------
                  (Name of Registrant as Specified in Charter)

has  caused  this  notification  to  be  signed on its behalf by the undersigned
hereunto  duly  authorized.

Date     May  15,  2003
     By:           /s/  Richard  D.  Brounstein
             ----------------------------------
     Richard  D.  Brounstein,  Executive  Vice
     President  and  Chief  Financial  Officer


INSTRUCTION: The form may be signed by an executive officer of the registrant or
by  any  other duly authorized representative.  The name and title of the person
signing  the  form  shall  be  typed  or  printed beneath the signature.  If the
statement  is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign  on  behalf  of  the  registrant  shall  be  filed  with  the  form.

INTENTIONAL  MISSTATEMENTS  OR  OMISSIONS  OF  FACT  CONSTITUTE FEDERAL CRIMINAL
VIOLATIONS  (SEE  18  U.S.C.  1001).