SCHEDULE 14C
                                 (RULE 14C-101)
                  INFORMATION REQUIRED IN INFORMATION STATEMENT
                            SCHEDULE 14C INFORMATION
                 INFORMATION STATEMENT PURSUANT TO SECTION 14(C)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

Check the appropriate box:


                                        
[X] Preliminary information statement      [   ] Confidential, for Use of the Commission
                                                 only (as permitted by Rule 14c-5(d)(2))
[  ] Definitive information statement


- --------------------------------------------------------------------------------

                         MANHATTAN PHARMACEUTICALS, INC.

                  (Name of Registrant as Specified in Charter)

          Payment of Filing Fee (Check the appropriate box):

          [X]  No fee required.

          [ ]  Fee computed on table below per Exchange Act Rules 14c-5(g) and
               0-11.

          (1)  Title of each class of securities to which transaction applies:

          (2)  Aggregate number of securities to which transaction applies:

          (3)  Per unit price or other underlying value of transaction  computed
               pursuant to Exchange Act Rule 0-11 (set forth the amount on which
               the filing fee is calculated and state how it was determined):

          (4)  Proposed maximum aggregate value of transaction:

          (5)  Total fee paid:

          [ ]  Fee paid previously with preliminary materials.

          [ ]  Check  box if any  part  of the  fee is  offset  as  provided  by
               Exchange  Act Rule  0-11(a)(2)  and identify the filing for which
               the  offsetting  fee was paid  previously.  Identify the previous
               filing by registration  statement number, or the Form or Schedule
               and the date of its filing.

               (1)  Amount Previously Paid:

               (2)  Form, Schedule or Registration Statement No.:

               (3)  Filing Party:

               (4)  Date Filed:





                         MANHATTAN PHARMACEUTICALS, INC.
                         787 SEVENTH AVENUE, 48TH FLOOR
                            NEW YORK, NEW YORK 10019

                                  June __, 2003


Dear Stockholder:

         This Information Statement is being furnished to the stockholders of
Manhattan Pharmaceuticals, Inc. (formerly Atlantic Technology Ventures, Inc.), a
Delaware corporation (the "Company"), in connection with the proposed
combination of the Company's common stock on a 2-for-3 basis. Although the
approval of the Company's stockholders is required to effect a stock
combination, a resolution authorizing the proposed stock combination has been
consented to in writing by the approval of the holders of more than 57 percent
of our outstanding common stock. Accordingly, it is not necessary for the
Company to call a special meeting of stockholders to consider the proposed stock
combination and your approval is not required and is not being sought.

         We are proposing the combination of our common stock in order to allow
us to have a sufficient number of authorized but unissued shares to be able to
issue in connection with potential financings that we may wish to undertake. Our
certificate of incorporation authorizes us to issue up to 150,000,000 shares of
common stock. We currently have 116,811,950 shares of common stock outstanding,
and another 19,830,869 shares of common stock reserved for issuance pursuant to
outstanding stock options and warrants, leaving only 13,357,151 shares available
for issuance.

         This Information Statement enclosed herewith provides further
information about the Company and the proposed stock combination. Please
carefully read the document in its entirety. You may also obtain other
information about the Company from publicly available documents that have been
filed with the Securities and Exchange Commission.

                                        Very truly yours,



                                        Leonard Firestone
                                        President & Chief Executive Officer






                         MANHATTAN PHARMACEUTICALS, INC.
                         787 SEVENTH AVENUE, 48TH FLOOR
                            NEW YORK, NEW YORK 10019
                        ---------------------------------

                         NOTICE OF ACTION TO BE TAKEN BY
          WRITTEN CONSENT OF STOCKHOLDERS IN LIEU OF A SPECIAL MEETING
                           AND INFORMATION STATEMENT
                        ---------------------------------


         This Information Statement is being mailed to stockholders of Manhattan
Pharmaceuticals, Inc. (formerly Atlantic Technology Ventures, Inc.), a Delaware
corporation (the "Company," "we," "us" or "our"), in connection with the
approval by the holders of a majority of the Company's outstanding common stock
of a resolution approving the combination or "reverse stock split," of the
Company's common stock on a 2-for-3 basis. In order to effect a reverse stock
split, it is necessary for the Company to obtain the approval of stockholders.
However, stockholders holding an aggregate of more than 57 percent of our
outstanding common stock have already consented in writing to a resolution
authorizing the Company to effect a 2-for-3 reverse split. Accordingly, pursuant
to our bylaws and the General Corporation Law of Delaware, the Company will not
call a special meeting of stockholders to consider the proposed stock
combination and your vote is not being solicited. This Notice of Action to be
Taken by Stockholders in Lieu of a Special Meeting and Information Statement is
furnished to you solely for the purpose of informing stockholders of this
corporate action before it takes effect, in the manner required under the
Securities Exchange Act of 1934, as amended.

         The written consents that we have received from holders of more than 57
percent of our outstanding common stock authorize us to effect a 2-for-3 reverse
stock split at any time prior to July 1, 2003. This Information Statement was
first sent to holders (other than the stockholders who have already provided
their written consent authorizing the reverse split) of our outstanding common
stock on or about June ___, 2003. Other than common stock, we have no other
shares of any other class of our capital stock outstanding.


                      WE ARE NOT ASKING YOU FOR A PROXY AND
                    YOU ARE REQUESTED NOT TO SEND US A PROXY.







GENERAL; PURPOSE

         As of May 15, 2003, we had 116,811,980 shares of common stock
outstanding and an additional 19,830,869 shares of common stock reserved for
issuance upon the exercise of outstanding options and warrants. Our certificate
of incorporation authorizes us to issue only up to 150,000,000 shares of capital
stock, meaning that we are only authorized to issue an additional 13,357,151
shares of common stock. In light of the current market price of our common
stock, the number of remaining shares that we are authorized to issue limits our
flexibility to raise additional capital through equity financings. In order to
increase the number of shares of common stock that we are authorized to issue,
our Board of Directors has unanimously adopted a resolution seeking stockholder
approval authorizing the Board of Directors to amend our Certificate of
Incorporation to effect a reverse split of our common stock. The ratio of the
reverse stock split that the Board of Directors approved and deemed advisable
and to which the holders of a majority of our outstanding common stock have
consented is 2-for-3. This means that, when effected, every 3 shares of common
outstanding prior to the stock combination will represent only 2 shares of
common stock after the combination. Accordingly, the proposed 2-for-3 reverse
stock split will provide us with greater flexibility in raising additional
capital by making approximately 45,500,000 additional shares of common stock
available for issuance.

         Following the effective time of the reverse split, we intend to raise
additional capital through private placements of our equity securities.
Nevertheless, the terms of any such financing transactions are still
undetermined and there can be no assurance that we will conclude any such
financing. To date, we have not engaged in any negotiations with potential
investors regarding any private placement of our equity securities. The proceeds
from any such financing will be used primarily to provide us with working
capital. If we are able to successfully negotiate a private placement of equity
or equity-related securities, the private placement would likely involve the
issuance, or potential issuance in the case of convertible securities, of at
least 13 million shares of our common stock. Accordingly, any such private
placement will generally have the effect of diluting the interests of existing
stockholders.

         Holders of more than 57 percent of our outstanding common stock have
consented in writing to the proposed stock combination. The resolution consented
to by these stockholders authorizes us to effect the combination any time prior
to July 1, 2003. Accordingly, prior to that time, we will file a Certificate of
Amendment to our Certificate of Incorporation with the Secretary of State of the
State of Delaware (as described below) which will effect a combination of the
shares of our common stock then issued and outstanding at a ratio of 2-for-3.
The reverse split will not change the number of authorized shares of common
stock or preferred stock or the par value of our common stock or preferred
stock. Except for any changes resulting from the treatment of fractional shares,
each stockholder will hold the same percentage of common stock outstanding
immediately after the combination as such stockholder did immediately prior to
the combination.

CERTAIN RISKS ASSOCIATED WITH THE STOCK COMBINATION

THERE CAN BE NO  ASSURANCE  THAT THE TOTAL MARKET  CAPITALIZATION  OF OUR COMMON
STOCK AFTER THE PROPOSED STOCK  COMBINATION WILL BE EQUAL TO OR GREATER THAN THE
TOTAL MARKET  CAPITALIZATION  BEFORE THE PROPOSED STOCK  COMBINATION OR THAT THE
PER SHARE MARKET PRICE OF OUR COMMON STOCK FOLLOWING THE COMBINATION WILL EITHER
EXCEED OR REMAIN HIGHER THAN THE CURRENT PER SHARE MARKET PRICE.

         There can be no assurance that the market price per new share of our
common stock (the "New Shares") after the stock combination will rise or remain
constant in proportion to the reduction in the number of old shares of our
common stock (the "Old Shares") outstanding before the stock combination. For
example, based on the market price of our common stock on May 15, 2003 of $0.15
per share, following a 2-for-3 reverse split there can be no assurance that the
post-split market price of our common

                                       2




stock  would be $0.22  per  share or  greater.  Accordingly,  the  total  market
capitalization of our common stock after the proposed reverse stock split may be
lower than the total market  capitalization  before the proposed  reverse  stock
split and, in the future,  the market  price of our common stock  following  the
reverse  stock split may not exceed or remain higher than the market price prior
to  the  proposed   reverse  stock  split.  In  many  cases,  the  total  market
capitalization  of a company  following a reverse  stock split is lower than the
total market capitalization before the reverse stock split.

A DECLINE IN THE MARKET PRICE FOR OUR COMMON STOCK AFTER THE REVERSE STOCK SPLIT
MAY RESULT IN A GREATER  PERCENTAGE DECLINE THAN WOULD OCCUR IN THE ABSENCE OF A
REVERSE  STOCK SPLIT,  AND THE  LIQUIDITY OF OUR COMMON STOCK COULD BE ADVERSELY
AFFECTED FOLLOWING A REVERSE STOCK SPLIT.

          The market price of our common stock will also be based on our
performance and other factors, some of which are unrelated to the number of
shares outstanding. If the reverse stock split is effected and the market price
of our common stock declines, the percentage decline as an absolute number and
as a percentage of our overall market capitalization may be greater than would
occur in the absence of a reverse stock split. In many cases, both the total
market capitalization of a company and the market price of a share of such
company's common stock following a reverse stock split are lower than they were
before the reverse stock split. Furthermore, the liquidity of our common stock
could be adversely affected by the reduced number of shares that would be
outstanding after the reverse stock split.

PRINCIPAL EFFECTS OF THE REVERSE STOCK SPLIT

          CORPORATE MATTERS. If approved and effected, the reverse stock split
would have the following effects:

               o    every 3 Old Shares owned by a stockholder would be exchanged
                    for 2 New Shares;

               o    the  number  of  shares  of  our  common  stock  issued  and
                    outstanding  will be  reduced  proportionately  based on the
                    2-for-3 split ratio;

               o    based on the 2-for-3 ratio,  proportionate  adjustments will
                    be made to the per share  exercise  price and the  number of
                    shares issuable upon the exercise of all outstanding options
                    and  warrants  entitling  the  holders  thereof to  purchase
                    shares  of  our  common   stock,   which   will   result  in
                    approximately  the same aggregate price being required to be
                    paid for such  options or  warrants  upon  exercise  of such
                    options or warrants immediately  preceding the reverse stock
                    split; and

               o    the  number  of  shares  reserved  for  issuance  under  our
                    existing stock option plans will be reduced  proportionately
                    based on the 2-for-3 split ratio.

         When effected, the reverse stock split will be effected simultaneously
for all of our common stock and the ratio will be the same for all of our common
stock. The reverse stock split will affect all of our stockholders uniformly and
will not affect any stockholder's percentage ownership interests in our company,
except to the extent that the reverse stock split results in any of our
stockholders owning a fractional share. As described below, stockholders holding
fractional shares will be entitled to cash payments in lieu of such fractional
shares. Such cash payments would reduce the number of post-split stockholders to
the extent there are stockholders presently holding fewer than 2 shares. This,
however, is not the purpose for which we are effecting the reverse stock split.
Common stock issued pursuant to the reverse stock split will remain fully paid
and non-assessable. We will continue to be subject to the periodic reporting
requirements of the Securities Exchange Act of 1934, as amended.

                                       3




         FRACTIONAL SHARES. No scrip or fractional certificates will be issued
in connection with the reverse stock split. Stockholders who otherwise would be
entitled to receive fractional shares because they hold a number of Old Shares
not evenly divisible by the number selected by the Board of Directors for the
reverse stock split ratio will be entitled, upon surrender of certificate(s)
representing such shares, to a cash payment in lieu thereof. The cash payment
will equal the product obtained by multiplying (a) the fraction to which the
stockholder would otherwise be entitled by (b) the per share closing sales price
of our common stock on the day immediately prior to the effective time of the
reverse stock split, as reported on the Over-the-Counter Bulletin Board. The
ownership of a fractional interest will not give the holder thereof any voting,
dividend or other rights except to receive payment therefor as described herein.

         Stockholders should be aware that, under the escheat laws of the
various jurisdictions where our stockholders reside, where we are domiciled and
where the funds will be deposited, sums due for fractional interests that are
not timely claimed after the effective time may be required to be paid to the
designated agent for each such jurisdiction. Thereafter, stockholders otherwise
entitled to receive such funds may have to seek to obtain them directly from the
state to which they were paid.

         If approved and effected, the reverse stock split will result in some
stockholders owning "odd lots" of less than 100 shares of our common stock.
Brokerage commissions and other costs of transactions in odd lots are generally
somewhat higher than the costs of transactions in "round lots" of even multiples
of 100 shares.

         AUTHORIZED SHARES. Upon the effectiveness of the reverse stock split,
the number of authorized shares of common stock that are not issued or
outstanding would increase due to the reduction in the number of shares of our
common stock issued and outstanding based on the 2-for-3 reverse stock split
ratio. As of May 15, 2003, we had 150,000,000 shares of common stock authorized
for issuance, 116,811,980 shares of common stock issued and outstanding and an
additional 19,830,869 shares authorized for issuance upon exercise of
outstanding options and warrants. Accordingly, after giving effect to the
proposed reverse stock split, we will have only 77,874,653 shares of common
stock outstanding and 13,220,579 shares authorizes for issuance under out
outstanding options and warrants. We will continue to have 10,000,000 authorized
but unissued shares of preferred stock. Authorized but unissued shares will be
available for issuance, and we may issue such shares in financings or otherwise.
If we issue additional shares, the ownership interest of holders of our common
stock may also be diluted. Also, the issued shares may have rights, preferences
or privileges senior to those of our common stock.

         ACCOUNTING MATTERS. The reverse stock split will not affect the par
value of our common stock, which is $.001 per share. As a result, as of the
effective time of the reverse stock split, the stated capital on our balance
sheet attributable to our common stock will be reduced proportionately based on
the 2-for-3 split ratio, and the additional paid-in capital account will be
credited with the amount by which the stated capital is reduced. The per share
net income or loss and net book value of our common stock will be restated
because there will be fewer shares of common stock outstanding.

         POTENTIAL ANTI-TAKEOVER EFFECT. Although the increased proportion of
unissued authorized shares to issued shares could, under certain circumstances,
have an anti-takeover effect (for example, by permitting issuances that would
dilute the stock ownership of a person seeking to effect a change in the
composition of our Board of Directors or contemplating a tender offer or other
transaction for the combination of us with another company), the reverse stock
split is not being proposed in response to any effort of which we are aware to
accumulate shares of our common stock or obtain control of our company, nor is
it part of a plan by management to recommend a series of similar amendments to
our Board of Directors and stockholders. Other than the reverse stock split
proposal, we do not currently contemplate recommending the adoption of any other
amendments to our Certificate of Incorporation that could be construed to affect
the ability of third parties to take over or change the control of our company.

                                       4




PROCEDURE FOR EFFECTING REVERSE STOCK SPLIT AND EXCHANGE OF STOCK CERTIFICATES

      In order to effect the 2-for-3 reverse split, we will file a Certificate
of Amendment to our Certificate of Incorporation ("Amendment") with the
Secretary of State of the State of Delaware to amend our existing Certificate of
Incorporation. The reverse stock split will become effective at the time
specified in the Amendment, which is referred to below as the "effective time."
Beginning at the effective time, each certificate representing Old Shares will
be deemed for all corporate purposes to evidence ownership of New Shares. The
text of the Amendment to effect the reverse stock split will be in substantially
the form attached hereto as APPENDIX A; provided, however, that the text of the
form of Amendment attached hereto is subject to modification to include such
changes as may be required by the office of the Secretary of State of the State
of Delaware and as the Board of Directors deems necessary and advisable to
effect the reverse stock split, including the insertion of the effective time
determined by the Board of Directors.

          As soon as practicable after the effective time, stockholders will be
notified that the reverse stock split has been effected. We expect that our
transfer agent, Continental Stock Transfer and Trust Company, will act as
exchange agent for purposes of implementing the exchange of stock certificates.
Holders of Old Shares will be asked to surrender to the exchange agent
certificates representing Old Shares in exchange for certificates representing
New Shares in accordance with the procedures to be set forth in the letter of
transmittal that we send to our stockholders. No new certificates will be issued
to a stockholder until such stockholder has surrendered such stockholder's
outstanding certificate(s), together with the properly completed and executed
letter of transmittal, to the exchange agent. Any Old Shares submitted for
transfer, whether pursuant to a sale, other disposition or otherwise, will
automatically be exchanged for New Shares. STOCKHOLDERS SHOULD NOT DESTROY ANY
STOCK CERTIFICATE(S) AND SHOULD NOT SUBMIT ANY CERTIFICATE(S) UNTIL REQUESTED TO
DO SO.

NO DISSENTERS' RIGHTS

      Under the Delaware General Corporation Law, our stockholders are not
entitled to dissenters' rights with respect to the reverse stock split, and we
will not independently provide stockholders with any such right.

FEDERAL INCOME TAX CONSEQUENCES OF THE REVERSE STOCK SPLIT

          The following is a summary of certain material federal income tax
consequences of the reverse stock split, does not purport to be a complete
discussion of all of the possible federal income tax consequences of the reverse
stock split and is included for general information only. Further, it does not
address any state, local or foreign income or other tax consequences. Also, it
does not address the tax consequences to holders that are subject to special tax
rules, such as banks, insurance companies, regulated investment companies,
personal holding companies, foreign entities, nonresident alien individuals,
broker-dealers and tax-exempt entities. The discussion is based on the
provisions of the United States federal income tax law as of the date hereof,
which is subject to change retroactively as well as prospectively. This summary
also assumes that the Old Shares were, and the New Shares will be, held as a
"capital asset," as defined in the Internal Revenue Code of 1986, as amended
(i.e., generally, property held for investment). The tax treatment of a
stockholder may vary depending upon the particular facts and circumstances of
such stockholder. Each stockholder is urged to consult with such stockholder's
own tax advisor with respect to the tax consequences of the reverse stock split.

      Other than the cash payments for fractional shares discussed below, no
gain or loss should be recognized by a stockholder upon such stockholder's
exchange of Old Shares for New Shares pursuant to the reverse stock split.
The  aggregate  tax basis of the New Shares  received in the reverse stock split

                                       5




(including any fraction of a New Share deemed to have been received) will be the
same as the  stockholder's  aggregate  tax  basis  in the Old  Shares  exchanged
therefor.  In  general,  stockholders  who receive  cash in  exchange  for their
fractional  share  interests in the New Shares as a result of the reverse  stock
split  will  recognize  gain  or loss  based  on  their  adjusted  basis  in the
fractional share interests  redeemed.  The stockholder's  holding period for the
New Shares will  include the period  during which the  stockholder  held the Old
Shares surrendered in the reverse stock split.

      Our view regarding the tax consequences of the reverse stock split is not
binding on the Internal Revenue Service or the courts. ACCORDINGLY, EACH
STOCKHOLDER SHOULD CONSULT WITH HIS OR HER OWN TAX ADVISOR WITH RESPECT TO ALL
OF THE POTENTIAL TAX CONSEQUENCES TO HIM OR HER OF THE REVERSE STOCK SPLIT.

VOTE REQUIRED

      The affirmative vote of the holders of a majority of all outstanding
shares of our common stock entitled to vote on this proposal was required for
approval of this proposal. As of May 15, 2003, we had obtained written consents
authorizing the 2-for-3 reverse split from holders of more than 57 percent of
our outstanding common stock.

                              SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain information regarding beneficial
ownership of the our common stock as of May 15, 2003, by (i) each person known
by us to be the beneficial owner of more than 5 percent of the outstanding
common stock, (ii) each director, (iii) each executive officer, and (iv) all
executive officers and directors as a group. The number of shares beneficially
owned is determined under rules promulgated by the SEC, and the information is
not necessarily indicative of beneficial ownership for any other purpose. Under
those rules, beneficial ownership includes any shares as to which the individual
has sole or shared voting power or investment power and also any shares which
the individual has the right to acquire within 60 days of May 15, 2003, through
the exercise or conversion of any stock option, convertible security, warrant or
other right. Including those shares in the tables does not, however, constitute
an admission that the named stockholder is a direct or indirect beneficial owner
of those shares. Unless otherwise indicated, each person or entity named in the
table has sole voting power and investment power (or shares that power with that
person's spouse) with respect to all shares of capital stock listed as owned by
that person or entity. Unless otherwise indicated, the address of each of the
following persons is 787 Seventh Avenue, 48th Floor, New York, New York 10019.




                                                                          SHARES
        NAME                                                        BENEFICIALLY OWNED       PERCENT OF CLASS

                                                                                                
        Leonard Firestone.............................................            0                    *
        Nicholas J. Rossettos(1)......................................      287,500                    *
        Joshua Kazam..................................................    1,220,129                  1.0
        Michael Weiser................................................    6,837,806                  5.9
        Joan Pons(2)..................................................            0                    *
        David M. Tanen(3).............................................    1,871,236                  1.6
        All directors and officers as a group(4)......................   10,216,671                  8.7

        Lindsay A. Rosenwald(5).......................................   13,569,320                 11.6
        Oleoylestrone Developments, SL(6).............................   20,785,188                 17.8
            Josep Samitier 1-5, Barcelona Science Park
            08028 Barcelona Spain


                                       6






                                                                          SHARES
        NAME                                                        BENEFICIALLY OWNED       PERCENT OF CLASS

                                                                                                


       Jay Lobell(7).................................................   18,848,450                 16.1
            365 West End Avenue
            New York, New York 10024



         ------------------------

          *  Less than 1.0%

(1)  Represents shares issuable upon the exercise of options that are currently
     exercisable or will become exercisable within 60 days.

(2)  Does not include any shares beneficially owned by Oleoylestrone
     Developments, SL, of which Mr. Pons is chief executive officer.

(3)  Includes 28,333 shares issuable upon the exercise of options that are
     currently exercisable or will become exercisable within 60 days.

(4)  Includes 165,833 shares issuance upon the exercise of options. Does not
     include any shares held by Oleoylestrone Developments, SL, of which Mr.
     Pons is chief executive officer.

(5)  Includes 190 shares of common stock held by Huntington Street Corporation
     and 190 shares of common stock held by June Street Corporation. Dr.
     Rosenwald is the sole owner of both Huntington Street Corporation and June
     Street Corporation.

(6)  Mr. Pons is the chief executive officer of Oleoylestrone Developments, SL.

(7)  Includes 18,721,353 shares of common stock held by eight separate trusts
     with respect to which Mr. Lobell is either trustee or manager and in either
     case has investment and voting power.


                       WHERE YOU CAN FIND MORE INFORMATION

         We file annual, quarterly and current reports, proxy statements and
other information with the SEC. You may read and copy any reports, statements or
other information we file at the SEC's public reference rooms in Washington,
D.C., and Chicago, Illinois. Please call the SEC at 1-800-SEC-0330 for further
information on the public reference rooms. Our SEC filings are also available to
the public from commercial document retrieval services and at the internet
website maintained by the SEC at: HTTP://WWW.SEC.GOV.

- --------------------------------------------------------------------------------
YOU SHOULD RELY ONLY ON THE INFORMATION CONTAINED IN THIS INFORMATION STATEMENT.
WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH INFORMATION THAT IS DIFFERENT
FROM WHAT IS CONTAINED IN THIS INFORMATION STATEMENT. THIS INFORMATION STATEMENT
IS DATED JUNE __, 2003. YOU SHOULD NOT ASSUME THAT THE INFORMATION CONTAINED IN
THIS INFORMATION STATEMENT IS ACCURATE AS OF ANY DATE OTHER THAN SUCH DATE, AND
THE MAILING OF THIS INFORMATION STATEMENT TO SHAREHOLDERS SHALL NOT CREATE ANY
IMPLICATION TO THE CONTRARY.
- --------------------------------------------------------------------------------

                                       7






                                                                      APPENDIX A

                            CERTIFICATE OF AMENDMENT
                                     OF THE
                          CERTIFICATE OF INCORPORATION
                                       OF
                         MANHATTAN PHARMACEUTICALS, INC.

                     Pursuant to Section 242 of the General
                    Corporation Law of the State of Delaware

         It is hereby certified that:

         1. Manhattan Pharmaceuticals, Inc. (formerly known as Atlantic
Technology Ventures, Inc.) is a corporation formed under the laws of the State
of Delaware, and its certificate of incorporation was filed in the office of the
Secretary of State on May 18, 1993.

         2. The certificate of incorporation is hereby amended by deleting the
text of Article FOURTH in its entirety and replacing it with the following:

                  FOURTH: A. The corporation is authorized to issue two classes
         of shares designated "Common Stock" and "Preferred Stock,"
         respectively. The total number of shares of Common Stock authorized to
         be issued is 150,000,000, and each such share will have a par value of
         $0.001. The total number of shares of Preferred Stock authorized to be
         issued is 10,000,000, and each such share will have a par value of
         $0.001. The rights, preferences, privileges and restrictions granted to
         and imposed upon the two classes of shares are as set forth in this
         Article and in the Certificate of Designations of Series A Convertible
         Preferred Stock.

                  B. Effective 12:01 a.m. on , 2003 (the "Effective Time") every
         three (3) shares of Common Stock of the Corporation issued and
         outstanding immediately prior to the Effective Time ("Old Common
         Stock") shall automatically be combined, without any action on the part
         of the holder thereof, into two (2) shares of fully paid and
         nonassessable Common Stock of the Corporation ("New Common Stock"),
         subject to the treatment of fractional shares interests described
         below.

                  C. Following the Effective Time, each holder of Old Common
         Stock shall be entitled to receive upon surrender of such holder's
         certificate(s) representing Old Common Stock (whether one or more, "Old
         Certificates") for cancellation pursuant to procedures adopted by the
         Corporation, a certificate(s) representing the number of whole shares
         of New Common Stock (whether one or more, "New Certificates") into
         which and for which the shares of Old Common Stock formerly represented
         by such Old Certificates so surrendered are reclassified under the
         terms hereof. From and after the Effective Time, Old Certificates shall
         represent only the right to receive New Certificates and, where
         applicable, cash in lieu of fractional shares, as provided below.

                  D. No fractional shares of Common Stock of the Corporation
         shall be issued. No stockholder of the Corporation shall transfer any
         fractional shares of Common Stock of the Corporation. The Corporation
         shall not recognize on its stock record books any purported transfer of
         any fractional share of Common Stock of the Corporation. A holder of
         Old Certificates at the Effective Time who would otherwise be entitled
         to a fraction of a share of New Common Stock shall, in lieu thereof, be
         entitled to receive a cash payment in an amount equal to the fraction


                                      A-1





         to which the stockholder would otherwise be entitled multiplied by the
         last reported per share sale price of the Common Stock on the day
         immediately prior to the Effective Time, as reported on the
         Over-the-Counter Bulletin Board (or if such price is not available,
         then such other price as determined by the Board of Directors).

                  E. The Board of Directors is hereby authorized, subject to
         limitations prescribed by law and the provisions of this Article
         Fourth, by resolution to provide for the issuance of the shares of
         Preferred Stock in one or more series, and to establish from time to
         time the number of shares to be included in each such series, and to
         fix the designation, powers, privileges, preferences, and relative
         participating, optional or other rights, if any, of the shares of each
         such series and the qualifications, limitations or restrictions
         thereof.

         3. This amendment to the certificate of incorporation has been duly
adopted in accordance with Section 242 of the General Corporation Law of the
State of Delaware.

         The undersigned is signing this certificate on ________, 2003.




                                         Leonard Firestone
                                         President and Chief Executive Officer

                                      A-2