Exhibit 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of CytRx  Corporation (the "Company") on
Form 10-Q for the period  ended June 30, 2003 as filed with the  Securities  and
Exchange  Commission on the date hereof (the "Report"),  I, Steven A. Kriegsman,
Chief  Executive  Officer and interim  Chief  Financial  Officer of the Company,
certify,  pursuant to 18 U.S.C.  ss. 1350, as adopted pursuant to ss. 906 of the
Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of
the Securities Exchange Act of 1934; and

(2) The  information  contained in the Report fairly  presents,  in all material
respects, the financial condition and results of operations of the Company.

A signed  original of this  written  statement  required by Section 906 has been
provided to CytRx  Corporation  and will be retained  by CytRx  Corporation  and
furnished to the Securities and Exchange Commission or its staff upon request.


/s/ STEVEN A. KRIEGSMAN
- ---------------------------------------
Steven A. Kriegsman
Chief Executive Officer
and Interim Chief Financial Officer
Date: August 14, 2003