Exhibit 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350
                    AS ADOPTED PURSUANT TO SECTION 906 OF THE
                           SARBANES-OXLEY ACT OF 2002

         In  connection  with  the  Annual  Report  on Form  10-K  of  Discovery
Laboratories,  Inc. (the  "Company")  for the period ended December 31, 2003, as
filed with the Securities and Exchange Commission (the "Commission") on the date
hereof (the "Report"), each of the undersigned, in his capacity as an officer of
the Company, certifies,  pursuant to 18 U.S.C. Section 1350, as adopted pursuant
to Section 906 of the Sarbanes-Oxley Act of 2002, that:

         1.       the Report fully  complies  with the  requirements  of Section
                  13(a) or  15(d) of the  Securities  Exchange  Act of 1934,  as
                  amended; and

         2.       the information  contained in the Report fairly  presents,  in
                  all material respects,  the financial condition and results of
                  operations of the Company.

         A signed original of this written statement  required by Section 906 of
the  Sarbanes-Oxley  Act of 2002 has been  provided  to the  Company and will be
retained  by the  Company  and  furnished  to the  Commission  or its staff upon
request.

Date:  March 15, 2005
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Name: /s/ Robert J. Capetola
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Name: Robert J. Capetola, Ph.D.
Title: President, and Chief Executive Officer

Name: /s/ John G. Cooper
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Name: John G. Cooper
Title: Senior Vice President, and Chief Financial Officer