UNITED STATES
                                        SECURITIES AND EXCHANGE COMMISSION
                                              WASHINGTON, D.C. 20549

                                                    FORM 12b-25
                                            NOTIFICATION OF LATE FILING

                                                Commission File Number
                                                                       ---------
(Check One):
[X] Form 10-K and Form 10-KSB    [ ] Form 11-K
[ ] Form 20-F                    [ ] Form 10-Q and Form 10-QSB    [ ] Form N-SAR

For Period Ended:   December 31, 2003
                  --------------------------------------------------------------

[ ] Transition Report on Form 10-K and Form 10-KSB
[ ] Transition Report on Form 20-F
[ ] Transition Report on Form 11-K
[ ] Transition Report on Form 10-Q and Form 10-QSB
[ ] Transition Report on Form N-SAR

For the Transition Period Ended:
                                 -----------------------------------------------

    Read Attached Instruction Sheet Before Preparing Form. Please Print or Type.

    Nothing in this form shall be  construed  to imply that the  Commission  has
verified any information contained herein.

    If the  notification  relates  to a portion  of the  filing  checked  above,
identify the item(s) to which the notification relates:
                                                        ------------------------

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                                     PART I
                             REGISTRANT INFORMATION

    Full name of registrant           AMARILLO BIOSCIENCES, INC.
                              --------------------------------------------------
    Former name if applicable
                              --------------------------------------------------

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    Address of principal executive office (Street and number)
                                                              ------------------
                                            4134 Business Park Drive
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    City, state and zip code                Amarillo, Texas 79110
                             ---------------------------------------------------




                                     PART II
                             RULES 12b-25(b) AND (c)

    If the subject  report  could not be filed  without  unreasonable  effort or
expense  and  the  registrant  seeks  relief  pursuant  to Rule  12b-25(b),  the
following should be completed. (Check box if appropriate.)

    (a)  The reasons  described  in  reasonable  detail in Part III of this form
         could not be eliminated without unreasonable effort or expense;

    (b)  The subject annual report,  semi-annual  report,  transition  report on
         Form 10-K, 10-KSB, Form 20-F, 11-K, Form N-SAR, or portion thereof
[X]      will be filed on or before the 15th calendar day following the
         prescribed due date; or the subject quarterly report or transition
         report on Form 10-Q, 10-QSB, or portion thereof will be filed on or
         before the fifth calendar day following the prescribed due date; and

    (c)  The accountant's  statement or other exhibit required by Rule 12b-25(c)
         has been attached if applicable.

                                    PART III
                                    NARRATIVE

    State below in reasonable detail the reasons why Forms 10-K,  10-KSB,  11-K,
20-F, 10-Q, 10-QSB, N-SAR or the transition report or portion thereof, could not
be filed within the prescribed time period.

Registrant  is a small  biotech  company  that  has  experienced  a  substantial
reduction in workforce.  Registrant currently has only one employee competent to
prepare the Company's  financials.  Due to that employee's  recent illness,  the
company  has not been able to  complete  its  financial  statements  in a timely
manner, and the auditors have been unable to commence their audit.

                                     12b25-1



                                     PART IV
                                OTHER INFORMATION

    (1) Name and  telephone  number  of  person  to  contact  in  regard to this
notification.

  Edward L. Morris                              806               372-2020
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     (Name)                                 (Area Code)       (Telephone Number)

    (2) Have all other  periodic  reports  required under Section 13 or 15(d) of
the Securities  Exchange Act of 1934 or Section 30 of the Investment Company Act
of 1940 during the  preceding  12 months (or for such  shorter)  period that the
registrant  was  required to file such  reports)  been  filed?  If answer is no,
identify report(s).
                                                             [X] Yes      [ ] No

    (3) Is it anticipated  that any significant  change in results of operations
from the corresponding  period for the last fiscal year will be reflected by the
earnings statements to be included in the subject report or portion thereof?

                                                             [ ] Yes      [X] No

     If so, attach an explanation of the anticipated  change,  both  narratively
and  quantitatively,  and, if  appropriate,  state the reasons why a  reasonable
estimate of the results cannot be made.

                                   Amarillo Biosciences, Inc.
- --------------------------------------------------------------------------------
                  (Name of Registrant as Specified in Charter)

Has  caused  this  notification  to be signed on its  behalf by the  undersigned
thereunto duly authorized.


Date: March 30, 2004         By:  /s/ Joseph M. Cummins
- ------------------------     ---------------------------------------------
                                  Joseph M. Cummins, President & CEO




Instruction: The form may be signed by an executive officer of the registrant or
by any other duly  authorized  representative.  The name and title of the person
signing  the form  shall  be typed or  printed  beneath  the  signature.  If the
statement is signed on behalf of the registrant by an authorized  representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

                                    ATTENTION

    Intentional misstatements or omissions of fact constitute federal criminal
violations (see 18 U.S.C. 1001).



                              GENERAL INSTRUCTIONS

1.  This form is required by Rule  12b-25 of the General  Rules and  Regulations
    under the Securities Exchange Act of 1934.

2.  One signed  original and four  conformed  copies of this form and amendments
    thereto  must be  completed  and  filed  with the  Securities  and  Exchange
    Commission,  Washington,  D.C.  20549,  in  accordance  with Rule 0-3 of the
    General Rules and Regulations under the Act. The information contained in or
    filed with the form will be made a matter of public record in the Commission
    files.

3.  A manually  signed copy of the form and  amendments  thereto  shall be filed
    with each national  securities  exchange on which any class of securities of
    the registrant is registered.

4.  Amendments to the  notifications  must also be filed on form 12b-25 but need
    not restate information that has been correctly furnished. The form shall be
    clearly identified as an amended notification.

5.  Electronic  Filers.  This form shall not be used by electronic filers unable
    to timely file a report solely due to electronic difficulties. Filers unable
    to submit a report within the time period  prescribed due to difficulties in
    electronic  filing  should  comply  with  either  Rule  201 or  Rule  202 of
    Regulation  S-T or apply for an  adjustment  in filing date pursuant to Rule
    13(b) of Regulation S-T.

                                     12b25-2