SCHEDULE 14A INFORMATION


                  PROXY STATEMENT PURSUANT TO SECTION 14(A) OF
                       THE SECURITIES EXCHANGE ACT OF 1934


Filed by the Registrant    |X|

Filed by a Party other than the Registrant    |_|

Check the appropriate box:

|_|   Preliminary Proxy Statement           |_|   Confidential, for Use of
                                                  the Commission Only (as
                                                  permitted by Rule 14a-6(e)(2))
|X|   Definitive Proxy Statement


|_|   Definitive Additional Materials

|_|   Soliciting Material Pursuant toss.240.14a-12


                         CALYPTE BIOMEDICAL CORPORATION
                (NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)


       (NAME OF PERSON(S) FILING PROXY STATEMENT IF OTHER THAN REGISTRANT)


Payment of Filing Fee (Check the appropriate box):

|X|   No fee required

|_|   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      (1)   Title of each class of securities to which transaction applies:

      (2)   Aggregate number of securities to which transaction applies:

      (3)   Per unit price or other  underlying  value of  transaction  computed
            pursuant  to  Exchange  Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):


      (4)   Proposed maximum aggregate value of transaction:

      (5)   Total fee paid:

|_|   Fee paid previously with preliminary materials.

|_|   Check box if any part of the fee is offset as  provided  by  Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.


      (1)   Amount Previously Paid:

      (2)   Form, Schedule or Registration Statement No.:

      (3)   Filing Party:

      (4)   Date Filed:

================================================================================



                     [CALYPTE BIOMEDICAL CORPORATION LOGO]
                             1265 Harbor Bay Parkway
                            Alameda, California 94502


May 3, 2004

Dear Stockholder:

      You are  cordially  invited  to attend  Calypte  Biomedical  Corporation's
Annual  Meeting of  Stockholders  on Thursday,  June 22, 2004.  The meeting will
begin promptly at 10:00 a.m. local time, at Signature Center, 5000 Hopyard Road,
4th Floor, Pleasanton, CA 94588.


      The official Notice of Annual Meeting of  Stockholders,  Proxy  Statement,
form of proxy and 2003 Annual  Report to  Stockholders  are  included  with this
letter.  The matters listed in the Notice of Annual Meeting of Stockholders  are
described in detail in the Proxy Statement.


      Your  vote is  important.  Whether  or not you plan to attend  the  annual
meeting,  I urge you to  complete,  sign and date the  enclosed  proxy  card and
return it in the  accompanying  envelope or vote by telephone or on-line as soon
as possible so that your stock may be represented at the meeting.


                                          Sincerely,

                                          /s/ Anthony J. Cataldo
                                          Anthony J. Cataldo
                                          Executive Chairman



                      [CALYPTE BIOMEDICAL CORPORATION LOGO]
                             1265 Harbor Bay Parkway
                            Alameda, California 94502


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 22, 2004

May 3, 2004

      The 2004 Annual Meeting of Stockholders of Calypte Biomedical  Corporation
(the "Company")  will be held at Signature  Center located at 5000 Hopyard Road,
4th Floor, Pleasanton,  California,  94588, on Thursday, June 22, 2004, at 10:00
a.m. local time, for the following purposes:


      1.    To elect six  directors of the Company to hold office until the next
            Annual Meeting of Stockholders or until their successors are elected
            and have been qualified;

      2.    To  vote  on the  proposed  adoption  of  the  2004  Incentive  Plan
            (Appendix D hereto)  and to  authorize  30,000,000  shares of Common
            Stock to be issued thereunder;

      3     To ratify the  appointment  by the Audit  Committee  of the Board of
            Directors  of Odenberg  Ullakko  Muranishi & Co. LLP as  independent
            auditors for the fiscal year ending December 31, 2004; and

      4.    To  transact  such other  business as may  properly  come before the
            Annual Meeting or any adjournment thereof.

      Stockholders  of record on May 3,  2004 will be  eligible  to vote at this
meeting.  Only stockholders of record at the close of business on that date will
be  entitled  to  notice  of  and  to  vote  at  the  meeting.  To  ensure  your
representation at the meeting,  you are urged to mark, sign, date and return the
enclosed  proxy as promptly as possible in the envelope  provided or to vote via
the internet or by telephone.  If you attend the meeting, you may vote in person
even if you return a proxy.



                                    By order of the Board of Directors,
                                    /s/ J. Richard George
                                    J. Richard George
                                    President and Chief Executive Officer



                             YOUR VOTE IS IMPORTANT
       WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING, PLEASE COMPLETE AND
              RETURN THE PROXY CARD IN THE ENVELOPE PROVIDED, WHICH
               REQUIRES NO POSTAGE IF MAILED IN THE UNITED STATES.



                     [CALYPTE BIOMEDICAL CORPORATION LOGO]
                             1265 Harbor Bay Parkway
                            Alameda, California 94502


                                 PROXY STATEMENT


      This Proxy Statement is furnished in connection  with the  solicitation of
proxies on behalf of the Board of Directors (the "Board") of Calypte  Biomedical
Corporation  ("Calypte" or the "Company") for the Annual Meeting of Stockholders
(the "Annual  Meeting"),  and any postponements or adjournments  thereof,  to be
held at Signature  Center  located at 5000 Hopyard Road,  4th Floor, Pleasanton,
California  94588,  on Thursday,  June 22, 2004, at 10:00 a.m.  local time.  The
telephone number at that address is (925) 847-0900. Every stockholder shall have
the right to vote  whether in person or by one or more  agents  authorized  by a
written  proxy  signed by the  stockholder  and filed with the  secretary of the
Company.  The shares  represented  by the proxies  received,  properly dated and
executed,  and not revoked will be voted at the Annual  Meeting.  A proxy may be
revoked  at any time  before it is  exercised  by  delivering  to the  Company a
written notice of revocation or a duly executed proxy bearing a later date or by
attending the Annual Meeting and voting in person.


                 INFORMATION CONCERNING SOLICITATION AND VOTING


      The close of  business  on May 3, 2004 has been fixed as the  record  date
(the "Record Date") for determining the holders of shares of common stock of the
Company,  par value $0.03 per share,  ("Common Stock") entitled to notice of and
to vote at the Annual Meeting. As of April 23, 2004, the Company had 140,162,698
shares of Common Stock  outstanding  and entitled to vote at the Annual Meeting.
The  holders  of a  majority  of voting  power of the  Common  Stock  issued and
outstanding  and entitled to vote,  present in person or  represented  by proxy,
shall constitute a quorum at the Annual Meeting except as otherwise  provided by
statute.  Each holder of Common Stock on the Record Date is entitled to one vote
for each share of Common Stock held by such stockholder,  and stockholders shall
not be entitled to cumulate  their votes in the  election of  directors  or with
respect to any matter submitted to a vote of the stockholders.


      Shares represented by proxies that reflect abstentions or broker non-votes
will be counted as shares that are present and  entitled to vote for purposes of
determining  the presence of a quorum.  Directors will be elected by a favorable
vote of a plurality of the shares of voting stock  present and entitled to vote,
in person or by proxy, at the Annual Meeting. Accordingly, abstentions or broker
non-votes as to the  election of  directors  will not affect the election of the
candidates receiving the plurality of votes. All of the proposals to come before
the Annual  Meeting  require  the  approval of a majority of the shares of stock
having voting power present.  Abstentions as to a particular  proposal will have
the same effect as votes against such proposal. Broker non-votes,  however, will
be treated as not voted for purposes of  determining  approval of such  proposal
and will not be counted as votes for or against such proposal.


      The shares  represented by all valid proxies received will be voted in the
manner specified on the proxies.  Where specific choices are not indicated,  the
shares  represented  by all valid proxies  received  will be voted:  (1) for the
nominees for director named in the Proxy Statement; (2) for adoption of the 2004
Incentive Plan and the authorization to reserve shares for issuance  thereunder,
and (3) for ratification of the appointment of Odenberg Ullakko  Muranishi & Co.
LLP, as independent auditors for the year ending December 31, 2004.


      Should any matter not  described  above be acted upon at the meeting,  the
persons named in the proxy form will vote in accordance with their judgment.


      The expense of printing and mailing proxy  materials  will be borne by the
Company.  In addition to the solicitation of proxies by mail,  solicitations may
be made by certain  directors,  officers  and other  employees of the Company by
personal interview,  telephone or facsimile.  No additional compensation will be
paid for such solicitation.  The Company may also, at its discretion, retain the
services  of a paid  solicitor  to solicit  proxies.  If the  Company  retains a
solicitor, it is anticipated that the cost will be approximately $5,500 and will
be paid by the Company.  The Company will request  brokers and nominees who hold
stock in their  names to furnish  proxy  material  to  beneficial  owners of the
shares  and will  reimburse  such  brokers  and  nominees  for their  reasonable
expenses incurred in forwarding solicitation material to such beneficial owners.


                                       1


                              ELECTION OF DIRECTORS

                                  (PROPOSAL 1)


      At the Annual  Meeting,  six  directors  are to be elected to hold  office
until the 2005  Annual  Meeting or until their  successors  are elected and have
been qualified. Each director, including a director elected or appointed to fill
a vacancy,  shall hold office until the expiration of the term for which elected
and until a successor has been elected or appointed and qualified.  There are no
family  relationships  among any of the  directors or executive  officers of the
Company.  The  nominees  listed below are all now Calypte  directors.  The Board
knows of no reason  why any  nominee  may be unable or  unwilling  to serve as a
director. If any nominee is unable or unwilling to serve, the shares represented
by all valid  proxies will be voted for the election of such other person as the
Board may  recommend.  The nominees  receiving the highest number of affirmative
votes will be elected to the Board.


      Certain information relating to each director nominee is set forth below:





NAME                          AGE            PRINCIPAL OCCUPATION                                     DIRECTOR
- ----                          ---            --------------------                                     --------
                                                                                             
Anthony J. Cataldo             53   Executive Chairman,                                                 5/02
                                    Calypte Biomedical Corporation

John J. DiPietro               46   Chief Financial Officer, Chronix                                   10/99
                                    Biomedical, Inc.

Paul E. Freiman                69   President and Chief Executive Officer, Neurobiological             12/97
                                    Technologies, Inc.

Julius R. Krevans, M.D.        80   Retired Chancellor Emeritus, Director of International              3/95
                                    Medical Services University of California, San
                                    Francisco

Maxim A. Soulimov              32   Director of Legal Affairs, Global Corporate Ventures                4/04
                                    Limited

Zafar I. Randawa, Ph.D.        55   Director of the New Technology Evaluation Division,                12/96
                                    Otsuka America Pharmaceutical



      ANTHONY J.  CATALDO was  appointed  Executive  Chairman  in May 2002.  Mr.
Cataldo  has held  management  positions  with a number of  emerging  growth and
publicly traded companies. He served as the Chief Executive Officer and Chairman
of the Board of  Directors  of Miracle  Entertainment,  Inc.,  a  Canadian  film
production  Company,  from May 1999 through May 2002 where he was the  executive
producer or producer of several  motion  pictures.  From August 1995 to December
1998, Mr. Cataldo served as President and Chairman of the Board of Senetek, PLC,
a publicly traded biotechnology company involved in age-related therapies.  From
1990 to 1995, Mr. Cataldo held various  positions  including  Chairman and Chief
Executive Officer with Management Technologies,  Inc., a manufacturer and seller
of trading system and banking software systems. He has also held the position of
Executive Vice President of Hogan Systems,  a banking software  manufacturer and
retailer.  Mr.  Cataldo has also served as  President  of  Internet  Systems,  a
pioneer in the Internet  banking arena.  Mr. Cataldo served in the United States
Air Force from 1969 to 1973.  Since October 2003,  Mr. Cataldo has served as the
Chairman of the Board of Directors of BrandPartners  Group, Inc. a publicly-held
brand building communication services company.

      JOHN J.  DIPIETRO  was  elected to the  Company's  Board of  Directors  in
October 1999. Since September 2002, he has served as the Chief Financial Officer
of Chronix Biomedical Inc, a private biotechnology company. Since February 2003,
Mr.  DiPietro  has also been a member of the Board of Chronix  Biomedical.  From
September  1999 to September  2002 he had been the Chief  Financial  Officer and
Vice  President-Finance  and  Administration  of  Tripath  Technology,  Inc.,  a
semi-conductor  manufacturing  company.  He served as Calypte's  Chief Operating
Officer,  Vice President of Finance,  Chief Financial Officer and Secretary from
December 1997 through  September 1999. From October 1995 until December 1997, he
served as Calypte's  Vice  President  of Finance,  Chief  Financial  Officer and
Secretary. Prior to joining the Company, he was Vice President of Finance, Chief
Financial  Officer and  Secretary  of Meris  Laboratories,  Inc., a full service
clinical  laboratory,  from 1991 until 1995. He is a Certified Public Accountant
and received  his M.B.A.  from the  University  of Chicago,  Graduate  School of
Business and a B.S. in Accounting from Lehigh University.


                                        2



      PAUL E. FREIMAN has served as a member of the Company's Board of Directors
since December 1997. He has served as the President and Chief Executive  Officer
of  Neurobiological  Technologies,  Inc.  since May 1997. In 1995,  Mr.  Freiman
retired  from his  position as Chairman  and Chief  Executive  Officer of Syntex
Corporation,  a  pharmaceutical  company.  From 1962 until 1994, he held several
other positions at Syntex  Corporation,  including President and Chief Operating
Officer.   Mr.   Freiman   is   currently   serving  on  the  board  of  Penwest
Pharmaceuticals Inc. and Neurobiological  Technologies,  Inc and several private
biotechnology   companies.   He  has  been   chairman   of  the   Pharmaceutical
Manufacturers  Association of America  (PhARMA) and has also chaired a number of
key PhARMA  committees.  Mr.  Freiman is also an advisor to Burrill & Co., a San
Francisco merchant bank.

      JULIUS R.  KREVANS,  M.D. has served on the  Company's  Board of Directors
since March 1995.  Dr.  Krevans  served as  Chancellor  Emeritus and Director of
International  Medical Care at University  of  California at San Francisco  from
1993 until his retirement in June 2002. From 1982 until 1993, Dr. Krevans served
as Chancellor at UCSF,  and was Dean of the School of Medicine at UCSF from 1971
until 1982.  Prior to this, Dr.  Krevans served as Dean for Academic  Affairs at
Johns Hopkins  University School of Medicine where he also served on the faculty
for 18 years and was  Professor  of Medicine  from 1968 until  1971.  He is also
Chairman of the Board of Directors of Neoprobe  Corporation  and a member of the
Board of Directors of AccuImage Corporation.  Dr. Krevans received his M.D. from
New York  University,  College of Medicine and completed a residency in Medicine
at Johns Hopkins University School of Medicine.


      MAXIM A.  SOULIMOV was  appointed to the  Company's  Board of Directors in
April 2004  pursuant  to an August 2003  agreement  between the Company and Marr
Technologies  BV ("MTBV") in which MTBV  purchased  $2.5 million of Common Stock
and the Company agreed to grant MTBV the right to appoint two mutually-agreeable
representatives   to  the  Board.   MTBV  is  currently  the  Company's  largest
stockholder,  holding  approximately  28% of the  Company's  outstanding  Common
Stock. Since November 2002, Mr. Soulimov has served as Director of Legal Affairs
of Global Corporate  Ventures  Limited  ("GCVL") of London, a company  providing
consultancy  services to a variety of private  investors  including Marr and its
affiliates.  From  April 2000  through  October  2002,  Mr.  Soulimov  served as
in-house  legal  counsel for Lukoil Europe  Limited and Lukoil  Europe  Holdings
Limited,  private companies  involved in the management of all Lukoil downstream
companies outside the Russian Federation. From September 1997 to April 2000, Mr.
Soulimov served as Trainee and then as Assistant Solicitor in the London firm of
Norton Rose  Solicitors.  Mr.  Soulimov holds a Degree in Modern  Languages from
Tver  State  University  in Russia  and an LLB Law  degree  from  University  of
Hertfordshire in the United Kingdom.

      ZAFAR I. RANDAWA,  PH.D.  has served on the  Company's  Board of Directors
since December 1996. Dr. Randawa is currently the Senior  Director of Research &
Development  of the Otsuka  Maryland  Research  Institute and has served in this
capacity  since  September  1995.  From 1989 until  September  1995, Dr. Randawa
served as a Chief Scientist at Otsuka America  Pharmaceutical,  Inc. Dr. Randawa
received his Ph.D. in  Biochemistry at Oregon Health  Sciences  University,  his
Master of Science  degree in  Biochemistry  at Karachi  University  in  Karachi,
Pakistan,  his B.Sc. in  Biochemistry  from Karachi  University  and his B.S. in
Chemistry from Panjab University in Lahore, Pakistan.

APPROVAL REQUIRED

      Approval of Proposal 1 requires the affirmative vote of a plurality of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.


      THE BOARD  UNANIMOUSLY  RECOMMENDS  A VOTE FOR THE  ELECTION  OF ALL NAMED
NOMINEES.  PROXIES  SOLICITED BY THE BOARD WILL BE SO VOTED UNLESS  STOCKHOLDERS
SPECIFY A DIFFERENT CHOICE IN THEIR PROXIES.



THE BOARD OF DIRECTORS AND COMMITTEES

      The Board of Directors met 10 times and acted by unanimous written consent
6 times during 2003. The Board has standing Audit,  Compensation  and Nominating
Committees.  All  directors  attended  at least 75% of the  aggregate  number of
meetings of the Board and the standing  committees  on which they served in 2003
during the period in which they served as directors.  In a continuing  effort to
enhance the Company's corporate  governance  practices and to more fully clarify
the  roles of the  Audit,  Compensation  and  Nominating  Committees,  the Board
adopted new charters for each of these  standing  Committees  in January 2004. A
copy of the Audit  Committee,  Compensation  Committee and Nominating  Committee
charters  as approved by the Board on January 19, 2004 is attached to this Proxy
Statement as Appendix A, Appendix B and Appendix C, respectively.


                                       3


AUDIT COMMITTEE

      The Audit  Committee  currently  consists of Mr. Freiman as Chairman,  Mr.
DiPietro,  and Dr. Randawa.  The Audit Committee assists the Board in fulfilling
its  oversight  responsibilities  relating  to the  integrity  of the  financial
statements,  compliance with legal and regulatory requirements,  the independent
auditor's   qualifications   and  independence,   and  the  performance  of  the
independent  auditor.  It is not the  duty  of the  Audit  Committee  to plan or
conduct audits,  to prepare the Company's  financial  statements or to determine
that the  Company's  financial  statements  and  disclosures  are  complete  and
accurate and are in accordance with generally accepted accounting principles and
applicable rules and regulations.  These are the  responsibilities of management
and the  independent  auditor.  In discharging its  responsibilities,  the Audit
Committee  engages the  Company's  independent  auditors,  approves the services
performed by such  auditors,  reviews and  evaluates  the  Company's  accounting
principles and its system of accounting controls,  and reviews with the auditors
the Company's  quarterly  unaudited and annual audited financial  statements and
the results of the reviews and audit thereof. The Audit Committee met 5 times in
2003. Four meetings were held to discuss the Company's financial  statements and
the  results of the  reviews  and audits  thereof  and one  meeting  was held to
discuss the informal inquiry by the Securities and Exchange  Commission  ("SEC")
into certain of the Company's  press releases and to engage  outside  counsel on
behalf of the Audit  Committee to conduct an  investigation  regarding the press
releases and related  information.  Additionally,  the Audit  Committee  and the
Board met  concurrently  once during  2003 to discuss the SEC's  inquiry and the
results of the  investigation  by the Audit  Committee's  outside  counsel.  See
"Report of Audit Committee" below.

      The Board has determined  that all current  members of the Audit Committee
are  independent  Directors and that each member of the Audit  Committee has the
ability to read and understand  fundamental financial statements.  The Board has
also determined that Mr. Freiman and Mr.  DiPietro  qualify as "Audit  Committee
financial  experts"  as  defined  under  Item  410(h) of  Regulation  S-B of the
Securities  Exchange Act of 1934 (the "Exchange  Act"). Mr. DiPietro served as a
member of the Audit  Committee  from January 2003 until May 2003, but because of
his  prior  consulting   agreement  with  the  Company,  he  did  not  meet  the
independence  requirements  for a member of the Audit  Committee  at that  time.
Consequently,  Dr. Randawa  replaced Mr.  DiPietro on the Audit Committee in May
2003.  In  January  2004,  subsequent  to his being  considered  independent  in
September  2003,  Mr.  DiPietro  was  re-appointed  to the Audit  Committee  and
replaced Dr. Krevans, who resigned from the Committee.


COMPENSATION COMMITTEE

      The  Compensation  Committee  consists of Dr.  Krevans as Chairman and Mr.
Freiman,  both  of  whom  are  independent  directors  who  have  served  on the
Compensation  Committee since at least 2000. The Compensation  Committee assists
the Board in fulfilling its oversight  responsibilities  relating to officer and
director  compensation,  succession planning for senior management,  development
and retention of senior  management,  and  administration of the Company's stock
option,  incentive and other benefit plans,  including,  without  limitation the
1995 Director  Option Plan (the "Director  Plan") and the 2000 Equity  Inventive
Plan (the  "2000  Plan").  The  Compensation  Committee  met twice in 2003.  See
"Compensation Committee Report on Executive Compensation" below.

NOMINATING COMMITTEE

      The  Nominating  Committee  consists of Mr.  Freiman as  Chairman  and Dr.
Krevans,  both of whom have served on the Nominating  Committee  since 2002. The
Nominating   Committee   assists   the  Board  in   fulfilling   its   oversight
responsibilities   relating  to  the  Company's  corporate  governance  matters,
including  the   determination  of  the  independence   status  of  current  and
prospective Board members,  periodic  evaluation of the Board of Directors,  its
committees and individual  directors,  and the  identification  and selection of
director  nominees.  The  Nominating  Committee  met  twice  and  acted  once by
unanimous written consent during 2003.


      The  Nominating  Committee  will  consider  stockholder   suggestions  for
nominees for director other than self-nominating suggestions. Suggestions may be
submitted  to the  Secretary  of the  Company  at the  Company's  administrative
offices.  The Committee will consider  suggestions  received by the  Secretary's
office  prior to December  31 at a meeting the  following  year,  preceding  the
mailing of proxy material to stockholders.


                                       4


DIRECTOR COMPENSATION

      The Company's  directors are  reimbursed  for their  out-of-pocket  travel
expenses associated with their attendance at Board meetings.  Under the terms of
the Director Plan, non-employee directors of the Company are eligible to receive
grants of options to purchase shares of Common Stock.  Non-employee directors of
the Company received no cash compensation from the Company during 2003 or since.


DIRECTOR OPTION PLAN

      The Board adopted the Director Plan in December 1995 and the  stockholders
approved  it in  1996.  The  Director  Plan  was most  recently  amended  at the
Company's May 2003 Annual  Stockholders'  Meeting at which time the stockholders
approved an increase in the number of shares  reserved for issuance to 2,000,000
shares.  The  Compensation  Committee  of the  Board  recommends  and the  Board
approves the number of non-qualified  stock options to purchase shares of Common
Stock that will be granted each year to newly-elected and re-elected  directors.
Options may be granted  under the  Director  Plan to  non-employee  directors or
directors  who also serve as  consultants  of the Company.  Each option  granted
under the Director Plan is  exercisable  at 100% of the fair market value of the
Common Stock on the date such option is granted. Each grant under the plan vests
monthly over the twelve  month period  commencing  with the  director's  date of
election or  re-election,  provided that the option will become vested and fully
exercisable  on the date of the next  annual  meeting  of  stockholders  if such
meeting occurs less than one year after the date of the grant. The Director Plan
will expire in 2005 and the Company  anticipates  that it will seek  stockholder
approval  for a new plan for the benefit of its  non-employee  directors  at its
2005 Annual Meeting of Stockholders.


      The  following  table shows the number of shares of Common Stock  issuable
upon exercise of options  granted under the Director Plan during the fiscal year
ended December 31, 2003 and through April 23, 2004.


                                                                 NUMBER OF
NAME AND POSITION                                                OPTIONS(1)
- -----------------                                                ----------
Anthony J. Cataldo, Director                                          0

John J. DiPietro, Director                                      305,000

Paul E. Freiman, Director                                       305,000

Dian J. Harrison, Former Director (2)                           106,667

Julius Krevans M.D., Director                                   305,000

Mark Novitch M. D., Former Director (3)                         105,000

Maxim A. Soulimov, Director (4)                                 200,000

Otsuka Pharmaceuticals Co Ltd. (Zafar Randawa, Director)        305,000

- --------------------

(1)   All options  were  granted at fair  market  value as of the date of grant.
      Unless otherwise noted,  during the period  specified,  each  non-employee
      Board  member was granted  options to purchase  5,000  shares at $0.32 per
      share in May  2003 for  service  on the  Board  during  2002;  options  to
      purchase  100,000 shares at $0.32 per share in May 2003 for service on the
      Board in 2003 and options to purchase  200,000  shares at $0.585 per share
      in February 2004 for service on the Board in 2004.

(2)   Ms.  Harrison  was granted  options to purchase  6,667 shares at $1.50 per
      share in March 2003 pursuant to her  appointment  as a member of the Board
      and options to purchase  100,000 shares at $0.32 per share in May 2003 for
      service on the Board in 2003.  All  non-vested  options were  subsequently
      cancelled  upon her  resignation as a member of the Board in July 2003. On
      September 5, 2003, when the market price of the Common Stock was $0.88 per
      share  and  prior  to the  expiration  of the  allowable  exercise  period
      following her  resignation,  Ms.  Harrison  exercised  8,333 of the vested
      options exercisable at $0.32 per share.

(3)   Dr.  Novitch was granted  options to  purchase  5,000  shares at $0.32 per
      share in May 2003 for service on the Board in 2002 and options to purchase
      100,000  shares at $0.32 per share for  service on the Board in 2003.  All
      non-vested  options were subsequently  cancelled upon his resignation as a
      member of the Board in July 2003.

(4)   Mr. Soulimov was granted  options to purchase  200,000 shares at $0.56 per
      share in April 2004 pursuant to his appointment as a member of the Board.


                                       5


      The  Company   believes  that  to  attract  and  retain  highly  qualified
candidates to serve as directors, it is important that directors have meaningful
equity  ownership  in  the  Company.   Initially,  the  reason  for  creating  a
non-discretionary  option plan for outside directors and for making such options
non-transferable  was to comply  with  rules of the SEC,  while  still  allowing
equity  participation by the outside  directors.  Subsequent rule changes by the
SEC have eliminated such  "disinterested"  administration  requirements  and the
Company  believes that the Board should have the  discretion to make  reasonable
use of all available means to attract and retain such highly qualified  director
candidates.

                      INFORMATION ON EXECUTIVE COMPENSATION


      The following table sets forth certain compensation awarded or paid by the
Company during the years ended  December 31, 2003,  2002 and 2001 to persons who
served as its Chief Executive Officer and as its other executive officers during
2003  (collectively,  the "Named Executive  Officers").  The compensation  table
excludes  other  compensation  in the form of  perquisites  and  other  personal
benefits  that  constitute  the lesser of $50,000 or 10% of the total salary and
bonus earned by each of the named Executive Officers in each fiscal year.

                           SUMMARY COMPENSATION TABLE



                                                                                          LONG-TERM
                                                                                        COMPENSATION
                                                                                         SECURITIES
                                                                                         UNDERLYING
                                                                                           OPTIONS             ALL OTHER
          NAME AND PRINCIPAL POSITION                YEAR       SALARY ($)   BONUS ($)    GRANTED (1)       COMPENSATION ($)
          ---------------------------                ----       ----------   ---------    -----------       ----------------
                                                                                             
Anthony J. Cataldo (2)                               2003       445,667 (3)       0       2,492,341 (4)               0
     Executive Chairman of the Board                 2002       185,726 (3)       0          30,000 (4)               0

J. Richard George (5)                                2003       135,692           0         103,494 (6)               0
     Chief Executive Officer and President

Nancy E. Katz (7)                                    2003       121,073           0       1,544,476 (8)         312,692 (9)
    Former President, Chief Executive                2002       265,269           0          14,049 (8)               0
       Officer and Member of the Board of            2001       239,039           0          30,000                   0
       Directors

Jay Oyakawa (10)                                     2003       209,941           0               0                   0
     Former President and Chief Operating
       Officer and Member of the Board

Richard D. Brounstein (11)                           2003       201,792           0         757,371(12)               0
    Executive Vice President and Chief               2002       122,596      15,000               0                   0
       Financial Officer; Former Member of the       2001         4,808           0          25,000 (13          26,000 (14)
       Board


- -------------------

(1)   All figures in this column represent options to purchase Common Stock.

(2)   Mr. Cataldo has served as Executive Chairman of the Board since May 2002.

(3)   At the Company's  request,  Mr. Cataldo deferred  approximately 30% of his
      cash salary from May 2002 through April 2003. The figure reported here for
      calendar  2002 is net of the deferral.  At December 31, 2002,  the Company
      had recorded expense totaling approximately $266,000, including an accrual
      of approximately  $80,000 for Mr. Cataldo's  deferred salary. All deferred
      amounts due Mr. Cataldo were paid during 2003 and the figure reported here
      for calendar 2003 reflects the payment of all such deferred amounts.

(4)   On May 10,  2002,  when the market price of the Common Stock was $0.90 per
      share and pursuant to his  employment  agreement,  Mr. Cataldo was granted
      fully-vested  options  to  purchase  65,556  shares at $0.45 per share and
      options to purchase 200,000 shares at $0.90 per share,  with the option to
      purchase 100,000 shares vested  immediately and the option to purchase the
      remainder  vested on the one-year  anniversary of the option grant. In the
      fourth quarter of 2002, the Company  renegotiated  the terms of the option
      grant in Mr. Cataldo's employment  agreement,  canceling all but 30,000 of
      the options granted at $0.90. Mr. Cataldo was subsequently granted 235,556
      fully-vested  options at an exercise price of $0.32 per share,  the market
      price  of the  Common  Stock on the May 29,  2003  grant  date,  following
      stockholder approval at the May 20, 2003 Annual  Stockholders'  Meeting of
      amendments to the Company's 2000 Plan. Additionally,  on May 29, 2003, Mr.
      Cataldo was granted  fully-exercisable  options to purchase 256,785 shares
      at $0.01 per share,  in  recognition  of an  additional  temporary  salary
      deferral  arrangement  beyond that described in (3) above,  and options to
      purchase  2,000,000  shares at $0.32 per share.  The latter  options  were
      exercisable  50% upon  grant  and 50% on the one year  anniversary  of the
      grant.


                                       6



(5)   Dr.  George has served as  President  and Chief  Executive  Officer  since
      January 2004.  He joined the Company in January 2003 as Vice  President of
      Government Affairs.

(6)   Represents a  fully-vested  option grant for 16,827  shares at an exercise
      price of $0.01 per share in  recognition  of a temporary  salary  deferral
      arrangement  and  grants of 6,667  shares and  80,000  shares,  both at an
      exercise  price of $0.32 per share,  which  vest over a three year  period
      from the grant date.

(7)   Ms. Katz served as President  and Chief  Executive  Officer from  December
      2001 to June 2003.  From June 2000 through  December  2001,  she served as
      President, Chief Executive Officer and Chief Financial Officer. She joined
      the Company in October 1999 as President,  Chief  Operating  Officer,  and
      Chief Financial Officer.

(8)   All of Ms. Katz'  unexercised  options,  together  aggregating  options to
      purchase  62,573  shares,  were  cancelled in the fourth  quarter of 2002.
      Subsequently,  Ms.  Katz was  granted  62,573  fully-vested  options at an
      exercise price of $0.32 per share, the market price of the Common Stock on
      the May 29, 2003 grant date, following stockholder approval at the May 20,
      2003 Annual Stockholders'  Meeting of amendments to the 2000 Plan. She was
      also granted  146,667  fully vested  options at $0.32 per share on May 29,
      2003  pursuant  to  her  amended   October  2002   employment   agreement.
      Additionally,  on May 29,  2003,  Ms. Katz was  granted  fully-exercisable
      options to purchase  85,236 shares at $0.01 per share, in recognition of a
      temporary salary deferral  arrangement,  and options to purchase 1,250,000
      shares of the Common  Stock at $0.32 per share.  The latter  options  were
      exercisable  50% upon  grant  and 50% on the one year  anniversary  of the
      grant.

(9)   Under the terms of a Separation  Agreement,  Mutual  Release and Waiver of
      Claims,  Ms.  Katz  resigned  effective  June  2,  2003  as the  Company's
      President and Chief  Executive  Officer and  effective  June 27, 2003 as a
      member  of the  Company's  Board  of  Directors.  Under  the  terms of the
      Separation  Agreement,  the Company  agreed to pay Ms. Katz  approximately
      $313,000 over a period of up to one year and to permit  previously  issued
      options to vest in accordance with the terms of their grants.  The Company
      paid Ms. Katz all amounts due pursuant to the Separation  Agreement during
      2003.

(10)  Mr. Oyakawa served as the Company's  President and Chief Operating Officer
      and member of the Board from June 2003 to January 2004. Under the terms of
      a January 19, 2004 Separation  Agreement and Release, Mr. Oyakawa resigned
      effective  January 19, 2004 from his  positions as an officer and director
      of the Company. The Company agreed to pay Mr. Oyakawa a severance equal to
      one year's salary of $350,000  over a twelve month period.  On January 15,
      2004, the Company granted.  Mr. Oyakawa options to purchase 750,000 shares
      of Common  Stock at an exercise  price of $0.32 per share.  At the time of
      Mr.  Oyakawa's  grant,  the market price of the Common Stock was $0.62 per
      share. Under the terms of the Separation Agreement and Release the options
      were fully vested. Mr. Oyakawa may exercise the options for two years from
      the date of grant.

(11)  Mr.  Brounstein has served as Executive Vice President and Chief Financial
      Officer  since  joining the Company in  December  2001.  He had served the
      Company as a financial consultant from July 2001 through December 2001. He
      served as a member of the Board from December 2001 until May 2003, when he
      did not stand for re-election.

(12)  All of Mr. Brounstein's options,  together aggregating options to purchase
      25,000  shares,  were  cancelled  in  the  fourth  quarter  of  2002.  Mr.
      Brounstein was granted 25,000 fully-vested options at an exercise price of
      $0.32 per share,  the market price of the Common Stock on the May 29, 2003
      grant  date,  following  stockholder  approval  at the May 20, 2003 Annual
      Stockholders' Meeting of amendments to the 2000 Plan. Under the terms of a
      January 2003 employment agreement, Mr. Brounstein was granted fully vested
      options to purchase  83,333 shares at an exercise price of $0.32 per share
      on May 29, 2003. Additionally, on May 29, 2003, Mr. Brounstein was granted
      fully-exercisable options to purchase 24,038 shares at $0.01 per share, in
      recognition of a temporary  salary  deferral  arrangement,  and options to
      purchase  625,000  shares at $0.32 per  share.  The  latter  options  were
      exercisable  50% upon  grant  and 50% on the one year  anniversary  of the
      grant.


                                       7


(13)  Represents  option  grant for  16,667  shares  pursuant  to an  employment
      agreement  between Mr.  Brounstein and the Company and an option grant for
      8,333 shares made pursuant to a July 2001 Consulting  Contract between Mr.
      Brounstein and the Company under which he served as a financial consultant
      to the Company.  All of these options were cancelled in the fourth quarter
      of 2002.

(14)  Represents cash payments made to Mr. Brounstein  pursuant to the July 2001
      Consulting Contract referred to in Note (13).

                     STOCK OPTION GRANTS IN LAST FISCAL YEAR
                                INDIVIDUAL GRANTS

      The  following  table  sets forth  information  concerning  stock  options
granted to the Named  Executive  Officers  during the fiscal year ended December
31, 2003:




                                                          PERCENT OF TOTAL
                             NUMBER OF SECURITIES         OPTIONS GRANTED        EXERCISE
                              UNDERLYING OPTIONS           TO EMPLOYEES IN       PRICE         EXPIRATION
NAME                               GRANTED                 FISCAL YEAR(1)        $/SH)(2)        DATE
- ----                               -------                 --------------        --------        ----
                                                                                 
Anthony J. Cataldo                256,785     (3)                2.80 %            0.01         5/29/13
                                  235,556     (4)                2.57 %            0.32         5/29/08
                                2,000,000     (5)               21.83 %            0.32         5/29/13

J. Richard George                  16,827     (3)                0.18 %            0.01         5/29/13
                                    6,667     (6)                0.07 %            0.32         5/29/13
                                   80,000     (7)                0.87 %            0.32         5/29/13

Nancy E. Katz (8)                  85,236     (3)                0.93 %            0.01         5/29/13
                                   62,573     (9)                0.68 %            0.32         5/29/13
                                  146,667    (10)                1.60 %            0.32         5/29/08
                                1,250,000     (5)               13.65 %            0.32         5/29/13

Jay Oyakawa (11)                        --                         --                --              --

Richard D. Brounstein              24,038     (3)                0.26%             0.01         5/29/13
                                   25,000     (9)                0.27%             0.32         5/29/13
                                   83,333    (12)                0.91%             0.32         5/29/08
                                  625,000     (5)                6.82%             0.32         5/29/13



- -----------------

(1)   Based on the aggregate of 8,528,626 options granted under the 2000 Plan to
      employees and  consultants to the Company and 631,667  options  granted to
      Directors under the Director Plan during the year ended December 31, 2003,
      including grants to the Named Executive Officers.

(2)   All  options  grants  reported  here were made on May 29,  2003,  when the
      market    price   of   the    Common    Stock   as    reported    on   the
      Over-The-Counter-Bulletin-Board was $0.32 per share.

(3)   Options  granted as fully vested under the 2000 Plan in  recognition  of a
      temporary salary deferral  arrangement.  The options expire ten years from
      the date of grant.

(4)   Options  granted as  fully-vested  under the 2000 Plan. The grant was made
      pursuant to Mr. Cataldo's May 2002 Employment  Agreement with the Company,
      but was deferred until May 29, 2003, following stockholder approval at the
      May 20, 2003 Annual Stockholders'  Meeting of amendments to the 2000 Plan.
      The options  expire  five years from the date of grant.  In the event of a
      change of control,  the options will become  fully vested and Mr.  Cataldo
      may exercise them for the shorter of the remainder of their five year term
      or two years from the effective date of the change of control.


                                       8



(5)   Options  granted under the 2000 Plan.  The options vest 50% on the date of
      grant and 50% on the one-year  anniversary  of the grant date. The options
      expire  ten  years  from the date of  grant.  In the  event of a change of
      control, the options will become fully vested and the grantee may exercise
      them for the shorter of the  remainder of their ten year term or two years
      from the effective date of the change of control.

(6)   Options granted under the 2000 Plan. The options vest at the rate of 1,117
      shares on the six month  anniversary of the May 29, 2003 grant date and at
      185 shares per month for the remaining 30 months.  The options will expire
      10 years from the date of grant.

(7)   Options  granted  under the 2000  Plan.  The  options  vest at the rate of
      13,340 shares on the six month  anniversary of the May 29, 2003 grant date
      and at 2,222  shares per month for the  remaining  30 months.  The options
      will expire 10 years from the date of grant.

(8)   Under the terms of the Separation Agreement,  Mutual Release and Waiver of
      Claims  between the Company and Ms. Katz, the Company agreed to permit the
      options issued to Ms. Katz during 2003 prior to her termination to vest in
      accordance with the terms of their grants.

(9)   Options granted under the 2000 Plan. These options were issued pursuant to
      the  Company's   fourth  quarter  2002   cancellation   of  the  grantee's
      previously-unexercised  options.  The options were granted as fully-vested
      and expire ten years from the May 29, 2003 grant  date.  In the event of a
      change of control, the grantee may exercise the options for the shorter of
      the remainder of their ten year term or two years from the effective  date
      of the change of control.

(10)  Options  granted  under the 2000 Plan.  The grant was made pursuant to Ms.
      Katz' October 2002 Employment Agreement with the Company, but was deferred
      until May 29,  2003,  following  stockholder  approval at the May 20, 2003
      Annual  Stockholders'  Meeting of amendments to the 2000 Plan. The options
      expire  five  years  from the date of  grant.  In the event of a change of
      control,  the options  will become  fully vested and Ms. Katz may exercise
      them for the shorter of the remainder of their five year term or two years
      from the effective date of the change of control.

(11)  Pursuant to the Employment  Agreement between the Company and Mr. Oyakawa,
      on January 15, 2004,  when the market value of the Common Stock was $0.62,
      the Company  granted Mr.  Oyakawa  options to purchase  750,000  shares of
      Common  Stock at $0.32 per share.  Under the terms of the January 19, 2004
      Separation  Agreement and Release between the Company and Mr. Oyakawa, the
      options became fully-vested.  Mr. Oyakawa may exercise the options for two
      years from the date of grant.

(12)  Options  granted  under the 2000 Plan.  The grant was made pursuant to Mr.
      Brounstein's  January 2003 Employment  Agreement with the Company, but was
      deferred until May 29, 2003, following stockholder approval at the May 20,
      2003 Annual  Stockholders'  Meeting of  amendments  to the 2000 Plan.  The
      options expire five years from the date of grant. In the event of a change
      of control,  the options will become fully vested and Mr.  Brounstein  may
      exercise  them for the shorter of the remainder of their five year term or
      two years from the effective date of the change of control.

The following table sets forth  information  concerning option exercises for the
year ended  December  31,  2003,  with  respect  to each of the Named  Executive
Officers.


                                       9




                       AGGREGATED OPTION EXERCISES IN 2003
                       AND DECEMBER 31, 2003 OPTION VALUES

                                                                       NUMBER OF SECURITIES           VALUE OF UNEXERCISED
                                 SHARES                              UNDERLYING UNEXERCISABLE         IN-THE-MONEY OPTIONS
                              ACQUIRED ON           VALUE          OPTIONS AT FISCAL YEAR END (#)       FISCAL YEAR END ($)
     NAME                     EXERCISE (#)     REALIZED ($)(2)      EXERCISABLE/UNEXERCISABLE)(1) (EXERCISABLE/UNEXERCISABLE)(1)(3)
     ----                     ------------     ---------------      ----------------------------- ---------------------------------
                                                                                      
Anthony J. Cataldo                        0                   0             1,522,341 / 1,000,000         227,639 / 145,000

J Richard George                          0                   0                   33,495 / 69,999           10,073 / 10,150

Nancy E. Katz (4)                   919,477             227,666                       0 / 624,999                0 / 90,625

Jay Oyakawa (5)                           0                   0                             0 / 0                     0 / 0

Richard D. Brounstein                     0                   0                 444,871 / 312,500           71,958 / 45,313



- --------------------

(1)   Reflects in-the-money options granted under the 2000 Plan.

(2)   Value realized is based on the fair market value of the shares on the date
      of exercise as reported on the  Over-The-Counter  Bulletin Board minus the
      exercise price multiplied by the number of shares acquired on exercise.

(3)   Value realized and value of unexercised in-the-money options is based on a
      value of $0.465  per  share of the  Common  Stock,  the  closing  price on
      December  31,  2003  as  quoted  on  the  Over-The-Counter-Bulletin-Board.
      Amounts reflect such fair market value minus the exercise price multiplied
      by the number of shares to be  acquired on  exercise  and do not  indicate
      that the optionee actually sold such stock.

(4)   Under the terms of the Separation Agreement,  Mutual Release and Waiver of
      Claims  between  the Company and Ms.  Katz,  the Company  agreed to permit
      options previously issued to Ms. Katz to vest in accordance with the terms
      of their grants.

(5)   Pursuant to the Employment  Agreement between the Company and Mr. Oyakawa,
      on January 15,  2004,  when the fair market  value of the Common Stock was
      $0.62,  the Company granted Mr. Oyakawa options to purchase 750,000 shares
      of the Common Stock at $0.32 per share. Under the terms of the January 19,
      2004 Separation Agreement and Release between the Company and Mr. Oyakawa,
      the options became fully-vested.  Mr. Oyakawa may exercise the options for
      two years from the date of grant.


             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

The  Compensation  Committee  of the  Board  of  Directors  is  responsible  for
administering the Company's executive  compensation  policies and programs.  The
Compensation  Committee  also reviews and approves the salaries and bonuses,  if
any,  of the  Company's  executive  officers  as well as all grants of long term
incentive and  equity-based  compensation  awards.  The  Compensation  Committee
currently consists of two directors,  each of whom are independent of management
and free from any  relationship  that, in the opinion of the Board of Directors,
would  interfere  with  the  exercise  of  their   independent   judgment  as  a
Compensation  Committee  member.   Further,  the  members  of  the  Compensation
Committee  are  directors  who qualify as  "non-employee  directors"  within the
meaning of Rule 16b-3 under the Securities  Exchange Act of 1934, as amended and
as  "outside  directors"  within the meaning of Section  162(m) of the  Internal
Revenue Code.

      Executive  Officer   Compensation   Policy.  The  Compensation   Committee
administers the Company's  executive  compensation  policies with the objectives
of:

      o     aligning  the  interests of executive  officers  with the  long-term
            interests of the Company's stockholders;

      o     providing  competitive  levels of  compensation  which are, in large
            part,   conditioned   on  the  Company's   attainment  of  specified
            performance targets and/or stock price appreciation; and


                                       10


      o     attracting,  motivating  and retaining  the best possible  executive
            talent for the benefit of the Company's stockholders.

      In assessing overall compensation for executive officers, the Compensation
Committee considers the Company's performance and industry position, and general
industry  data.  In  furtherance  of these goals,  the  components  of executive
compensation are linked to both Company and individual performance.

      Employment  Agreements.  Each Named  Executive  Officer is employed by the
Company pursuant to a written agreement of employment. Each employment agreement
reflects the terms that the  Compensation  Committee  believed were  appropriate
and/or necessary to retain the services of the particular  executive  officer at
the time it was executed,  within the  framework of the  Company's  compensation
policies and its financial condition.  The Compensation Committee has considered
the  advisability  of using  employment  agreements  and  determined  that under
certain  circumstances  it is in the  best  interests  of the  Company  and  its
stockholders  insofar as it permits the Company to achieve its desired  goals of
retaining the best  possible  executive  talent.  In addition,  each  employment
agreement   contains   restrictive   covenants,    including    non-competition,
non-solicitation and confidentiality  covenants, for the benefit of the Company.
The Compensation  Committee has determined that the use of employment agreements
may be necessary in certain  cases to help ensure the retention of key executive
officers,  to attract  additional  executive talent to the Company and to impose
appropriate restrictive covenants on such officers.

      Components  of  Executive  Compensation.  The  material  elements  of  the
Company's current executive  compensation  arrangements  include base salary and
equity incentive awards.  In 2003 and prior years,  equity awards were generally
granted in the form of options to purchase shares of Common Stock. This strategy
is intended to increase  the  beneficial  ownership  of Common  Stock by Company
executives while at the same time continuing to align their interests with those
of the Company's stockholders.

      The  Company  does  not  presently   have  a  formal  annual  bonus  plan.
Nevertheless,   subject  to  the  availability  of  sufficient  cash  resources,
executives  and certain  other key employees are eligible to earn annual cash or
stock  bonuses  for   achievement  of  both   Company-wide   and  individual  or
departmental goals.

      For 2004,  the  Company  expects to  continue  to use  options to purchase
Common  Stock as a  primary  vehicle  for  equity  grants to  further  align the
interests  of  Company  employees  with  Company  stockholders.  Subject  to the
stockholders'  approval  at the 2004 Annual  Meeting of Proposal 2 adopting  the
Company's 2004 Incentive  Plan, the Committee plans to grant options to purchase
an aggregate of 18,000,000 shares of Common Stock at an exercise price of $0.585
per  share to  seven  executives  and  other  key  employees.  The  Compensation
Committee and Company  management view this approach as the most appropriate and
effective  manner of meeting  the  critical  goal of  retaining  key  management
employees  and  minimizing  cash  outflows  while at the same time  aligning the
interests of key employees and  stockholders.  If approved by the  stockholders,
the  2004  Incentive  Plan  permits  the  Company  to issue a  variety  of other
equity-based  awards  in  addition  to stock  options,  which  the  Compensation
Committee and management may consider in the future.

      Base Salaries. Base salary represents the fixed component of the executive
compensation program.  Base salaries of the Executive Chairman,  Chief Executive
Officer,  Chief Financial Officer, Chief Operating Officer and senior management
are  determined  by  reviewing   comparable  market  base  salary  compensation,
individual performance, and relevant experience and demonstrated capabilities in
meeting the  requirements  of the  position.  The base salaries of the Executive
Chairman, Chief Executive, Financial and Operating Officers and other members of
Senior Management are determined by the Compensation  Committee's  evaluation of
the  Company's  attainment  of its  stated  overall  goals and  targets  and the
individual's contribution toward and performance in attaining such goals.


      Long-term  Incentive Awards. As noted previously,  the Committee  believes
that stock option grants serve to align the goals of the Company's  stockholders
and employees.  In addition to that  objective,  the Company's  stock option and
purchase  plans,  including  the proposed  2004  Incentive  Plan also assist the
Company in providing (1) a long-term incentive to help reduce employee turnover,
(2) a competitive  package for recruiting new employees,  (3) a long-term reward
for loyalty,  dedication and service, and (4) the vehicle for employees to share
in the rewards of "building stockholder value."


                                       11


      Executive Chairman Compensation

      In May 2002,  in  conjunction  with the  financing  proposal  enabling the
restart of the Company's  operations,  the independent  members of the Company's
Board  entered into a five-year  employment  agreement  with Anthony  Cataldo to
serve as the Company's Executive Chairman.  The employment agreement specifies a
base annual  salary of  $400,000  and allows for annual  increases  based on the
Company's   performance  and  approval  of  the  Compensation   Committee.   The
Compensation Committee has not adjusted Mr. Cataldo's base salary during 2003 or
subsequently.  The Company  deferred  approximately  30% of Mr.  Cataldo's  cash
compensation  during 2002, which it accrued.  The Company continued to defer and
accrue this compensation  until it was paid during the third quarter of 2003. On
May 10, 2002, when the market price of the Common Stock was $0.90 per share, the
Company  granted Mr. Cataldo  fully-vested  options to purchase 65,556 shares of
Common Stock at $0.45 per share and options to purchase 200,000 shares of Common
Stock at $0.90 per share,  with the option to  purchase  100,000  shares  vested
immediately  and the option to purchase  the  remainder  vesting on the one-year
anniversary  of the option grant.  Both option grants have a five-year  term. In
the fourth  quarter of 2002,  the Company  renegotiated  the terms of the option
grant contained in Mr. Cataldo's Employment Agreement,  canceling all but 30,000
of the options granted at $0.90. Subsequently, following stockholder approval at
the May 20, 2003 Annual Stockholders' Meeting of amendments to the 2000 Plan, on
May 29,  2003,  Mr.  Cataldo  was  granted  235,556  fully-vested  options at an
exercise price of $0.32 per share,  the market price of the Common Stock on that
date. Additionally,  on May 29, 2003, Mr. Cataldo was granted  fully-exercisable
options  to  purchase  256,785  shares of Common  Stock at $0.01 per  share,  in
recognition  of an  additional  salary  deferral  arrangement,  and  options  to
purchase 2,000,000 shares of Common Stock at $0.32 per share. The latter options
were  exercisable  50% upon  grant  and 50% on the one year  anniversary  of the
grant.  Subject to the approval by the Company's  stockholders  of Proposal 2 to
adopt the Company's 2004 Incentive Plan, the Committee plans to grant options to
purchase  5,000,000  shares of the Company's  common stock to Mr.  Cataldo at an
exercise  price of $0.585 per share,  the price of the Common  Stock on February
24, 2004,  the date the  Committee  approved the grant.  The options will have a
ten-year  term  and  will be  exercisable  50%  upon  grant  and  50%  one  year
thereafter.  The  Compensation  Committee  considers this level of  compensation
appropriate in view of Mr. Cataldo's background, leadership and accomplishments.

      Chief  Executive   Officer,   President,   and  Chief  Operating   Officer
Compensation

      In October 2002, the Company entered into a five-year employment agreement
with Nancy E. Katz, the Company's former  President and Chief Executive  Officer
and member of the Board, that included an annual salary of $300,000,  subject to
annual review.  The Compensation  Committee did not adjust Ms. Katz' base salary
prior to her  resignation in June 2003. In conjunction  with the agreement,  the
Company granted Ms. Katz options to purchase  146,667 shares of Common Stock, at
an exercise price of $2.40, subject to stockholder approval of amendments at the
2003 Annual Meeting of Stockholders  to the 2000 Plan.  These options were to be
fully vested on the grant date.  In February  2003,  the exercise  price of this
option was  reduced to the lesser of $1.50 per share or the market  price on the
grant date.  In the fourth  quarter of 2002,  Ms. Katz  permitted the Company to
cancel  all  outstanding  options  previously  granted  to her  under  the  1991
Incentive  Stock  Plan  and the 2000  Plan,  an  aggregate  of  62,573  options.
Subsequently,  following  stockholder  approval  at  the  May  20,  2003  Annual
Stockholders'  Meeting of  amendments  to the 2000 Plan,  on May 29,  2003,  the
Company  granted Ms. Katz 62,573  fully-vested  options at an exercise  price of
$0.32 per share,  the market price of the Common Stock on that date. The options
granted  conditionally  under Ms. Katz' October 2002  Employment  Agreement were
also granted as fully  vested at $0.32 per share on May 29, 2003.  Additionally,
on May 29,  2003,  Ms.  Katz was granted  fully-exercisable  options to purchase
85,236 shares of Common Stock at $0.01 per share,  in  recognition of an earlier
salary deferral arrangement,  and options to purchase 1,250,000 shares of Common
Stock at $0.32 per share. The latter options were exercisable 50% upon grant and
50% on the one year  anniversary  of the grant.  Under the terms of a Separation
Agreement, Mutual Release and Waiver of Claims, Ms. Katz resigned effective June
2, 2003 as the  Company's  President and Chief  Executive  Officer and effective
June  27,  2003 as a member  of the  Company's  Board.  Under  the  terms of the
Separation  Agreement,  the Company agreed to pay approximately  $313,000 over a
period  of up to one year and to permit  previously  issued  options  to vest in
accordance with the terms of their grants. All amounts due to Ms. Katz under the
Separation Agreement were paid during 2003.

      In June 2003, the Company  entered into a five year  employment  agreement
with Jay Oyakawa, the Company's former President and Chief Operating Officer and
member of the Board, that included an annual base salary of $350,000. On January
15, 2004,  when the market  price of the Common  Stock was $0.62 per share,  Mr.
Oyakawa  was  granted  options  to  purchase  750,000  shares  of  Common  Stock
exercisable  at $0.32  pursuant to the 2000 Plan.  The  options  vested 50% upon
grant and 50% on the one-year anniversary of the grant. On January 19, 2004, Mr.
Oyakawa resigned from his position as President,  Chief Operating Officer and as
a member of the Board.  The Company  entered  into a  Separation  Agreement  and
Release with Mr.  Oyakawa  effective  on January 19, 2004  pursuant to which the
Company  will pay him  severance  in an  amount  equal to one  year's  salary of
$350,000 over a twelve month period. Under the terms of the Separation Agreement
and  Release,  the options  became  fully-vested.  Mr.  Oyakawa may exercise the
options for two years from the date of grant.


                                       12


      In  January  2004,  the  Company  entered  into a  three  year  employment
agreement  with J.  Richard  George to serve as the  Company's  Chief  Executive
Officer and  President  and that  includes  an annual  base salary of  $250,000.
Subject to the approval by the Company's stockholders of Proposal 2 to adopt the
Company's 2004 Incentive  Plan, the Committee plans to grant options to purchase
5,000,000  shares of the  Company's  common  stock to Dr.  George at an exercise
price of $0.585 per share,  the price of the Common  Stock on February 24, 2004,
the date the Committee approved the grant. The options will have a ten-year term
and  will be  exercisable  50%  upon  grant  and 50% one  year  thereafter.  The
Compensation Committee considers this level of compensation  appropriate in view
of Dr. George's background, leadership and accomplishments.

      Chief Financial Officer Compensation

      On January 1, 2003,  the Company  entered into a twelve  month  employment
agreement,  with automatic  renewal  options,  with Richard D.  Brounstein,  the
Company's Executive Vice President and Chief Financial Officer, that included an
annual base  salary of  $200,000,  and the grant of options to  purchase  83,333
shares of Common  Stock at an  exercise  price of $1.50 per  share,  subject  to
stockholder approval of amendments at the 2003 Annual Meeting of Stockholders to
the 2000 Plan. The Compensation  Committee did not adjust Mr.  Brounstein's base
salary during 2003 or subsequently.  The options granted were to be fully vested
on the grant  date.  Mr.  Brounstein  had  previously  been  granted  options to
purchase  an  aggregate  of  25,000  shares  of  Common  Stock in 2001 and 2002,
pursuant to July 2001  consulting  contract under which he served as a financial
consultant  to the  Company.  In the  fourth  quarter  of 2002,  Mr.  Brounstein
permitted the Company to cancel all outstanding  options  previously  granted to
him.  Subsequently,  following  stockholder  approval at the May 20, 2003 Annual
Stockholders'  Meeting  of  amendments  to the 2000  Plan,  on May 29,  2003 Mr.
Brounstein was granted 25,000 fully-vested options at an exercise price of $0.32
per share,  the  market  price of the Common  Stock on that  date.  The  options
granted conditionally to Mr. Brounstein under his Employment Agreement were also
granted as fully vested at $0.32 per share on May 29, 2003. Additionally, on May
29,  2003,  Mr.  Brounstein  was granted  fully-exercisable  options to purchase
24,038 shares of Common Stock at $0.01 per share,  in  recognition of an earlier
temporary salary deferral arrangement, and options to purchase 625,000 shares of
Common Stock at $0.32 per share.  The latter options were  exercisable  50% upon
grant and 50% on the one year anniversary of the grant.  Subject to the approval
by the  Company's  stockholders  of  Proposal  2 to  adopt  the  Company's  2004
Incentive  Plan,  the  Committee  plans to grant  options to purchase  1,500,000
shares of the Company's  common stock to Mr.  Brounstein at an exercise price of
$0.585 per share,  the price of the Common Stock on February 24, 2004,  the date
the Committee approved the grant. The options will have a ten-year term and will
be  exercisable  50% upon  grant  and 50% one  year  thereafter.  The  Committee
considers this level of  compensation  appropriate  in view of Mr.  Brounstein's
background, leadership and accomplishments.

              SUBMITTED BY THE COMPENSATION COMMITTEE OF THE BOARD


                                              Julius Krevans, M.D.
                                              Paul Freiman

April 16, 2004

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

      During 2003, the  Compensation  Committee  consisted of Dr. Julius Krevans
and Mr. Paul Freiman, each of whom is a non-employee  director. No member of the
Compensation  Committee has a relationship that would constitute an interlocking
relationship with executive officers or directors of another entity.


                                       13


                            REPORT OF AUDIT COMMITTEE

The following  report of the Audit Committee of the Board shall not be deemed to
be incorporated by reference by any general statement incorporating by reference
this Proxy  Statement into any filing by the Company under either the Securities
Act of 1933,  as amended,  or the  Exchange  Act,  except to the extent that the
Company specifically  incorporates this information by reference.  The following
report shall not otherwise be deemed filed under such Acts.

Annual Report on Form 10-KSB

The role of the Audit Committee (the  "Committee") is to assist the Board in its
oversight of the Company's  financial  reporting  process.  The Audit  Committee
operates  pursuant to a Charter  that was last amended and restated by the Board
on  January  19,  2004.  Management  of  the  Company  is  responsible  for  the
preparation,  presentation and integrity of the Company's financial  statements,
the  Company's  accounting  and  financial  reporting  principles  and  internal
controls and procedures designed to assure compliance with accounting  standards
and applicable laws and  regulations.  The independent  auditors are responsible
for auditing the Company's financial  statements and expressing an opinion as to
their conformity with generally accepted accounting principles.


      In the performance of its oversight  function,  the Committee met and held
discussions  with management and Odenberg  Ullakko  Muranishi & Co. LLP (`OUM"),
the Company's independent auditors. Management represented to the Committee that
the Company's consolidated financial statements were prepared in accordance with
accounting principles generally accepted in the United States, and the Committee
reviewed and discussed the consolidated financial statements with management and
with OUM.  The  Committee  also  discussed  with OUM the matters  required to be
discussed by Statement on Auditing  Standards No. 61 (Codification of Statements
on Auditing Standards, AU 380), as amended.

      In addition,  the Committee discussed with OUM their independence from the
Company  and its  management,  and OUM  provided  to the  Committee  the written
disclosures  and  letter   required  from  the   independent   auditors  by  the
Independence Standards Board Standard No. 1 (Independence Discussions with Audit
Committees).

      The Committee discussed with the OUM the overall scope and plans for their
audit.  The  Committee  met with OUM, with and without  management  present,  to
discuss the results of their  examination,  their  evaluations  of the Company's
internal controls, and the overall quality of the Company's financial reporting.

      The  members  of the  Committee  are  not  professionally  engaged  in the
practice of auditing and therefore rely without independent  verification on the
information  provided to them and on the representations  made by management and
the independent auditors.  Accordingly, the Audit Committee's oversight does not
provide  an  independent  basis to  determine  that  management  has  maintained
appropriate   accounting  and  financial  reporting  principles  or  appropriate
internal  control and procedures  designed to assure  compliance with accounting
standards  and  applicable  laws  and   regulations.   Furthermore,   the  Audit
Committee's  reviews  and  discussions  referred to above do not assure that the
audit of the Company's  financial  statements has been carried out in accordance
with generally accepted auditing  standards,  that the financial  statements are
presented in accordance with generally  accepted  accounting  principles or that
the Company's auditors are in fact "independent."

      Based upon the reports  and  discussions  described  in this  report,  and
subject  to the  limitations  on the  role  and  responsibilities  of the  Audit
Committee  referred  to above and in the Audit  Committee's  Charter,  the Audit
Committee  approved the  inclusion of the audited  financial  statements  in the
Company's  Annual Report on Form 10-KSB for the year ended December 31, 2003 for
filing with the SEC.

SEC Informal Inquiry

      The Company was  contacted  by the San  Francisco  District  Office of the
Securities and Exchange  Commission (the  "Commission")  on October 28, 2003 and
advised that the enforcement  staff of the Commission was conducting an informal
inquiry regarding the Company. The Commission has requested, among other things,
documents  and  information  related to  certain  press  releases  issued by the
Company.  The  Commission has advised the Company that the inquiry should not be
construed as an indication by the  Commission or its staff that any violation of
law has occurred. The Company has voluntarily provided the information sought by
the  Commission and is  cooperating  with the Commission in connection  with its
informal inquiry.


                                       14


      Independently,  the Committee investigated the matter and retained outside
counsel to assist in its  investigation  by  reviewing  the press  releases  and
related  information that were the subject matter of the  Commission's  informal
inquiry  letter.  The  Committee  completed its  investigation  and reported the
results of its  investigation  and  associated  recommendations  to the Board of
Directors. Counsel for the Committee advised both the Committee and the Board of
Directors  that the  results of their  investigation,  interviews  and review of
documents  provided in  response to the  Commission's  informal  inquiry  letter
indicated no evidence of management malfeasance with respect to its inquiry. The
Committee, based upon its counsel's  recommendations,  proposed that the Company
implement  certain   practices  and  procedures,   some  of  which  represent  a
continuation or  formalization of present  practices.  The  recommendations  and
proposals of the  Committee  were approved by the Board of Directors and include
certain  improvements  in the  Company's  press  release  issuance  process  and
investor relations and regulatory recordkeeping  procedures.  Additionally,  the
Board of Directors  has directed  management  to  implement  the American  Stock
Exchange  corporate  governance  standards  (SR-AMEX-2003-65)  approved  by  the
Commission  on  December  1, 2003.  While  corporate  governance  is an on-going
process,  the Company has  substantially  implemented  our  recommendations  and
proposals and we and the Board have approved the updated  policies and charters,
including those attached as exhibits to this Proxy Statement.

Change of Auditors

      The Company's  interim  financial  statements  are required to be reviewed
under Statement of Auditing  Standards 100 ("SAS 100") by an independent  public
accountant  pursuant to Item 310(b) of  Regulation S B and our annual  financial
statements must be audited by an independent public accountant  pursuant to Item
310(a) of  Regulation  S B.  Calypte's  former  independent  auditors,  KPMG LLP
("KPMG"),  informed  the Company that they could not  complete  their  quarterly
review of the Company's interim financial  statements contained in the Company's
Quarterly  Report on Form 10-QSB for the  quarterly  period ended  September 30,
2003 or audit the  Company's  financial  statements  for its  fiscal  year ended
December  31,  2003 until such time as the Audit  Committee  had  completed  its
investigation  related to the Commission's informal inquiry letter, the same was
reviewed by KPMG,  and KPMG was  satisfied  that,  in its  opinion,  an adequate
investigation was conducted and appropriate conclusions were reached and actions
taken.

      On December 23, 2003, the Board dismissed KPMG as independent auditors for
the Company,  effective immediately,  at the recommendation of the Committee. As
of the date of KPMG's  dismissal,  KPMG had advised the Company  that, in KPMG's
opinion,  the  conditions  necessary for KPMG to complete its review had not yet
been satisfied. At the time of KPMG's dismissal, the Committee had completed its
investigation,  had reported  the results of its  investigation  and  associated
recommendations  to the  Board of  Directors,  and the  Board of  Directors  had
approved  the  recommendations.  Additionally,  at that  time,  counsel  for the
Committee  had advised the Company and the  Committee  that it had  commenced to
provide  to  KPMG  information  concerning  the  investigation   conducted,  the
conclusions reached and the actions taken by the Company.

      On December  24, 2003,  upon the  approval of and at the  direction of the
Committee,   the  Company  engaged  OUM  to  audit  the  consolidated  financial
statements of the Company for the two years ended December 31, 2003 and 2002 for
inclusion  in the  Company's  Annual  Report on Form  10-KSB  and to review  the
interim financial statements of the Company contained in its Quarterly Report on
Form 10-QSB for the quarterly period ended September 30, 2003. OUM has completed
the SAS 100 review  associated  with the Company's Form 10-QSB/A  (No.1) and its
audit of the Company's  financial  statements  for the years ended  December 31,
2003 and 2002.

      The  Committee  and the  Board  have  appointed,  subject  to  stockholder
ratification,  OUM as the  Company's  independent  auditors  for the fiscal year
ending December 31, 2004.


                  SUBMITTED BY THE AUDIT COMMITTEE OF THE BOARD


                                           Paul E. Freiman, Chairman
                                           John J. DiPietro
                                           Zafar I. Randawa, Ph.D.


April 16, 2004


                                       15


                    RELATIONSHIP WITH INDEPENDENT ACCOUNTANTS

      Odenberg  Ullakko  Muranishi & Co. LLP is the independent  accounting firm
that audited the Company's financial statements for the years ended December 31,
2003 and 2002.  As  indicated  in the Report of Audit  Committee,  OUM was first
engaged in December  2003.  OUM  performed  no services  for the Company  during
calendar  2003,  but performed  its audit and review  services for 2003 and 2002
during  calendar 2004. The aggregate fees billed to date during 2004 for each of
the following categories of services are set forth below:


Audit fees                                           $     $135,000
Audit-related fees                                   $           --
Tax fees                                             $           --
All other fees                                       $           --


      "Audit fees" include fees for the audits of the Company's annual financial
statements for 2003 and 2002 and the quarterly  review of the statements for the
quarter ended  September 30, 2003,  as well as fees for  consultation  regarding
accounting issues and their impact on or presentation in the Company's financial
statements.  "Audit-related  services"  consists  primarily  of  the  review  of
registration statements and the issuance of related consents. "Tax fees" include
tax planning and the  preparation  of the  Company's  tax returns.  OUM does not
provide  any tax or  financial  information  systems  design  or  implementation
services to the Company.

      The following table  summarizes fees billed for services for 2003 and 2002
by KPMG LLP, the Company's former auditors, for each of the following categories
of service:

                                                          2003            2002
Audit fees                                              $108,450        $160,000
Audit-related fees                                      $ 62,075        $ 83,000
Tax fees                                                      --        $ 23,500
All other fees                                          $ 53,365              --


      "Audit fees" include fees for the audit of the Company's  annual financial
statements  for 2002 and the quarterly  reviews of the  statements  for calendar
2002 and through September 30, 2003, as well as fees for consultation  regarding
accounting issues and their impact on or presentation in the Company's financial
statements.  "Audit-related  services"  consists  primarily  of  the  review  of
registration statements and the issuance of related consents. "Tax fees" include
tax planning and the  preparation  of the  Company's  tax returns.  KPMG did not
provide any financial  information systems design or implementation  services to
the Company.  "All other fees"  represents fees billed during the fourth quarter
of 2003 in  connection  with  KPMG's  review of  documentation  supplied  by the
Company to the Audit  Committee's  outside counsel related to the SEC's informal
inquiry.


                                       16


CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      In September  2001, the Company issued a $400,000 8.5%  Promissory Note to
the parent company of its then-largest stockholder. The Company renegotiated the
note during 2001, 2002 and subsequently in 2003. This note was repaid in 2003.


      In connection with MTBV's aggregate $12.5 million investment in the Common
Stock during 2003,  the Company signed a Memorandum Of  Understanding  with Marr
Technologies  Limited,  an affiliate of MTBV, to create a joint venture in China
to  market  the  Company's  current  and  future  products.   Additionally,  the
Nominating  Committee of the  Company's  Board agreed to grant MTBV the right to
appoint  two  mutually-agreeable  representatives  to the  Company's  Board at a
mutually-agreeable future date.


      In November 2003, the joint venture, Beijing Calypte Biomedical Technology
Ltd., was formed,  with the Company owning a 51% interest in the entity and Marr
Technologies Limited holding a 49% interest.  In April 2004, upon the nomination
by MTBV and the  recommendation  of the Nominating  Committee of the Board,  the
Company's Board appointed Maxim A. Soulimov as a member of the Board.



                                       17


                             STOCK PERFORMANCE CHART


      The graph below compares the cumulative  total  stockholder  return on the
Common  Stock  assuming  an  initial   investment  on  December  31,  1998.  The
Corporation's  return is shown with the  cumulative  total  return of the NASDAQ
Stock Market--U.S. Index and the Nasdaq Biotechnology Index. The graph assumes a
$100 investment made at the beginning of the respective  period and reinvestment
of all dividends.


                          [GRAPHIC CHART APPEARS HERE]


                                       18


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      Except as set forth in the footnotes to this table,  the  following  table
sets forth  information  known to the  Company  with  respect to the  beneficial
ownership of its Common Stock as of April 23, 2004 for (i) all persons  known by
the Company to own  beneficially  more than 5% of its outstanding  Common Stock,
(ii) each of the Company's  directors,  (iii) each Named  Executive  Officer and
(iv) all directors and executive officers of the Company as a group.




                                                             SHARES
                                                          BENEFICIALLY       % OF
5% STOCKHOLDERS, DIRECTORS AND OFFICERS(1)                    OWNED        TOTAL(2)
- ------------------------------------------                    -----        --------
                                                                     
Marr Technologies BV (3)                                   39,915,151       27.76
    Strawinskylaan 1431
    1077XX, Amsterdam
    The Netherlands

Anthony J. Cataldo (4)                                      5,022,341        3.46

Richard D. Brounstein (5)                                   1,507,371        1.06

J. Richard George (6)                                       2,544,606        1.78

John DiPietro (7)                                             305,245           *

Paul Freiman (8)                                              309,901           *

Julius Krevans, M.D.(9)                                       308,001           *

Zafar Randawa, Ph.D.(10)                                      351,372           *

Maxim A. Soulimov (11)                                        200,000           *

All current directors and
  executive officers as a group (8 persons)                10,349,302        6.88


- -------------------


 * Represents beneficial ownership of less than 1%.

(1)   To the Company's  knowledge,  except as set forth in the footnotes to this
      table and subject to applicable community property laws, each person named
      in this table has sole  voting and  investment  power with  respect to the
      shares  set  forth  opposite  such  person's  name.  Except  as  otherwise
      indicated, the address of each of the persons in this table is as follows:
      c/o Calypte  Biomedical  Corporation,  1265 Harbor Bay  Parkway,  Alameda,
      California 94502.

(2)   Based on 140,162,698 shares outstanding as of April 23, 2004.

(3)   As reported in  Amendment  No. 3 to  Schedule  13D dated  December 2, 2003
      filed with the Securities and Exchange Commission.  Marat Safin has voting
      and investment control over shares held by Marr Technologies BV.

(4)   Includes  5,022,341 shares subject to options  exercisable within 60 days.
      The grant of  2,500,000  options  is subject to  stockholder  approval  of
      Proposal 2 herein.

(5)   Includes  1,507,371 shares subject to options  exercisable within 60 days.
      The grant of  750,000  options  is  subject  to  stockholder  approval  of
      Proposal 2 herein.

(6)   Includes  2,544,606 shares subject to options  exercisable within 60 days.
      The grant of  2,500,000  options  is subject to  stockholder  approval  of
      Proposal 3 herein.

(7)   Includes 305,000 shares subject to options exercisable within 60 days.

(8)   Includes 309,901 shares subject to options exercisable within 60 days.

(9)   Includes 308,001 shares subject to options exercisable within 60 days.


                                       19


(10)  Includes 308,267 shares subject to options exercisable within 60 days. Dr.
      Randawa  is  a  director  of  the  Company  and  an  affiliate  of  Otsuka
      Pharmaceutical Co., Ltd. All shares listed are held by Otsuka. Dr. Randawa
      disclaims  beneficial  ownership of the shares except to the extent of his
      affiliation with Otsuka.

(11)  Includes  200,000  shares subject to options  exercisable  within 60 days.
      Marr Technologies BV ("Marr"),  the holder of 38,915,151 shares of Calypte
      Common  stock  (the "Marr  Holdings")  has the right to  nominate  two (2)
      candidates to serve on the Calypte Board of  Directors.  Mr.  Soulimov was
      nominated by Marr and  subsequently  appointed as a director upon approval
      of the Calypte Board of Directors.  Mr.  Soulimov  disclaims any direct or
      indirect  beneficial  ownership of Marr Holdings and does not exercise any
      control nor does he take part in any  investment  decisions  undertaken by
      Marr and does not have a direct or  indirect  pecuniary  interest  in Marr
      Holdings.


COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT

      Section 16(a) of the Exchange Act ("Section 16(a)") requires the Company's
executive  officers,  directors,  and  persons  who  own  more  than  10% of the
Company's Common Stock  (collectively,  "Reporting  Persons") to file reports of
ownership  on Form 3 and  changes  in  ownership  on  Form 4 or Form 5 with  the
Commission.  Such  Reporting  Persons are also  required by the  Securities  and
Exchange  Commission  rules to furnish  the  Company  with copies of all Section
16(a) forms that they file.  The Company  believes that during fiscal year 2003,
all the Reporting Persons complied with all applicable filing requirements.


                                       20


                                   ADOPTION OF
                       THE CALYPTE BIOMEDICAL CORPORATION
                               2004 INCENTIVE PLAN
                                  (PROPOSAL 2)


      On  February  24,  2004,  the Board  adopted,  subject to  approval by the
stockholders  at the Annual Meeting,  the Calypte  Biomedical  Corporation  2004
Incentive  Plan,  (the "2004  Plan").  The text of the 2004 Plan is  attached as
Appendix D to this Proxy Statement  Stockholders  are being asked to approve the
adoption of the 2004 Plan and to approve the reservation for issuance thereunder
of up to 30,000,000 shares of Common Stock.



      Purpose.  The purpose of the 2004 Plan is to attract,  retain and motivate
officers,  employees (including prospective  employees),  consultants and others
who  may  perform  services  for the  Company,  to  compensate  them  for  their
contributions  to the  long-term  growth  and  profits  of the  Company,  and to
encourage  them to acquire a proprietary  interest in the success of the Company
by providing  them with the  opportunity  to acquire  Common Stock or to receive
monetary  payments  based on the value of the Common  Stock or on the  financial
performance of the Company,  or both, on  advantageous  terms.  The 2004 Plan is
designed to permit the Company to provide  several  different forms of awards to
meet competitive  conditions,  including incentive stock options,  non-qualified
stock options, stock appreciation rights, dividend equivalent rights, restricted
stock,  restricted stock units, other  equity-based or equity-related  award and
incentive awards based on achievement of performance  goals  (collectively,  the
"Awards").

      General.  The 2004 Plan  authorizes the granting of Awards with respect to
an  aggregate  of  30,000,000  shares of Common  Stock.  The  30,000,000  shares
reserved under the 2004 Plan equal  approximately 21% of the outstanding  Common
Stock as of April 23, 2004. The 2004 Plan will replace the 2000 Equity Incentive
Plan (the "2000 Plan").  As of April 23, 2004,  under the 2000 Plan,  options to
purchase 7,861,180 shares of Common Stock were outstanding and less than 300,000
shares reserved were available for additional  grants.  The Common Stock covered
by the 2004 Plan may be  either  authorized  but  unissued  shares  or  treasury
shares.  If there is a  forfeiture,  expiration,  termination,  cancellation  or
settlement  for cash of any  Award  granted  under  the 2004  Plan  without  the
issuance of shares, the shares covered by such forfeited, terminated or canceled
Award or  equal to the  number  of  shares  settled,  surrendered,  withheld  or
tendered, shall again become available for transfer pursuant to Awards under the
2004 Plan.

      The  following  summary of certain  provisions of the 2004 is qualified in
its  entirety by  reference to the copy of the 2004 Plan set forth in Appendix C
to this Proxy Statement.

      Administration.  The 2004 Plan  provides  that  grants of Awards and other
determinations under the Plan shall be made by (i) the Compensation Committee of
the Board or (ii) the Board (the  "Administrator").  To the extent  required for
Awards to qualify  for the  exemptions  available  under Rule 16b-3  promulgated
under the Exchange Act, the  Compensation  Committee  will be composed of two or
more directors,  each of whom is a  "non-employee  direct" within the meaning of
Exchange Act Rule 16b-3. To the extent required for  compensation  realized from
Awards  to be  deductible  by the  Company  pursuant  to  Section  162(m) of the
Internal  Revenue  Code of 1986,  as  amended  (the  "Code"),  the  Compensation
Committee will be composed of two or more directors, each of whom is an "outside
director" within the meaning of Section 162(m) of the Code.

      Performance  Based  Compensation.  Section 162(m) of the Code limits to $1
million  annually the income tax  deduction a public  corporation  may claim for
compensation paid to any of its top five executive  officers,  except in limited
circumstances. One such exception is for "performance based compensation," which
is defined as  compensation  paid solely on account of the  attainment of one or
more  performance  goals,  but  only  (1)  if  the  goals  are  determined  by a
compensation  committee  of the  board  of  directors  comprised  of two or more
outside  directors,  (2) the performance goals are disclosed to stockholders and
approved by a majority vote before the  remuneration is paid, and (3) before the
remuneration is paid, the Compensation  Committee certifies that the performance
goals and any other material terms were in fact satisfied.

      Internal   Revenue   Service   regulations   provide   that   compensation
attributable  to a stock  option or stock  appreciation  right will be deemed to
satisfy the requirement that performance goals be preestablished if the grant of
the award is made by a properly appointed  Compensation  Committee  appointed by
the Board;  the plan under which the award is granted  states the maximum number
of shares  with  respect to which  options  or rights  may be  granted  during a
specified  period to any employee;  and, under the terms of the option or award,
the amount of  compensation  the  employee  could  receive is based solely on an
increase in the value of the stock after the date of the grant or award.  In the
case of all other types of awards, the performance  criteria must be established
within 90 days  after the  commencement  of the  period of  service to which the
performance goal relates, and the performance goal must be objective and capable
of determination by a third party having knowledge of the relevant facts.


                                       21


      The 2004 Plan includes  features  intended to permit the  Administrator to
grant Awards to employees that will qualify as  performance-based  compensation.
The 2004 Plan limits the number of shares with respect to which  incentive stock
options,  non-qualified  stock  options,  and stock  appreciation  rights may be
granted in any one calendar year to any one individual  participant to 8,000,000
shares of Common Stock.  The 2004 Plan further  limits the number of shares with
respect to which  restricted  stock or restricted  stock units may be granted in
any one calendar year to any one individual  participant to 8,000,000  shares of
Common  Stock.  The 2004 Plan also  provides  that the total  value of any Award
intended  to  qualify  as  performance-based  compensation  granted  to any  one
individual participant in any calendar year is limited to $1 million, based upon
the value of the Award assuming  performance  goals met on the date of the Award
grant. The 2004 Plan provides that the Administrator  may condition  exercise of
an Award on attainment of an objective performance goal or goals based on one or
more of the following performance criteria: earnings (either in the aggregate or
on a per-share basis),  total stockholder  return,  return on equity,  return on
capital,  net income,  cash flow,  operating  income or profit,  gross revenues,
economic value added, or strategic business criteria.  The levels of performance
required  with  respect to  Performance  Goals may be  expressed  in absolute or
relative levels.

      Eligibility.  Awards  under  the 2004  Plan may be made to such  officers,
employees (including prospective  employees),  consultants and other individuals
who may perform  services for the Company,  as the  Compensation  Committee  may
select.

      Types of Awards. Awards may be made under the 2004 Plan in the form of (a)
options,  (b) stock  appreciation  rights,  (c) dividend  equivalent rights, (d)
restricted  stock,  (e)  restricted  stock  units,  (f)  other  equity-based  or
equity-related  Awards which the Committee  determines to be consistent with the
purpose of the 2004 Plan and the  interests of the Company  (including,  but not
limited to, stock bonuses and warrants),  and (g) incentive awards. No incentive
stock option may be granted to a non-employee.

            Stock  Options.  The Incentive  Plan permits the granting of options
      that are either  incentive stock options  ("ISOs") or  nonqualified  stock
      options  ("NSOs").  ISOs  may be  granted  only  to  employees  (including
      officers  and  directors  who are also  employees)  of the  Company or any
      parent or subsidiary of the Company.  The option  exercise  price for each
      ISO share must be no less than 100% of the "fair market value" (as defined
      in the  2004  Plan)  of a share  of  Common  Stock  at the time the ISO is
      granted. In the case of an ISO granted to a 10% stockholder,  the exercise
      price for each such ISO share must be no less than 110% of the fair market
      value of a share of Common  Stock at the time the ISO is  granted.  If the
      shares  of Common  Stock  subject  to a  participant's  ISO  which  become
      exercisable for the first time during any calendar year have a fair market
      value in excess of $100,000, the options for the excess will be treated as
      NSOs.

            The  exercise  price of options  granted  under the 2004 Plan may be
      paid in cash or by such  other  method  as the  Committee  may  prescribe,
      provided,  however,  that any participant  exercising rights and obtaining
      shares  pursuant  to awards  granted  under the 2004 Plan must pay cash or
      other valid  consideration equal to the aggregate par value of such shares
      to the extent required by the Delaware General Corporation Laws. Any taxes
      required to be  withheld  must be paid by the  participant  at the time of
      exercise.  The  Company  may  deduct  or  withhold  from  any  payment  or
      distribution an amount sufficient to satisfy such withholding  obligation.
      The grantee may elect to have the Company  withhold shares of Common Stock
      or may tender  previously  owned  shares of Common  Stock to  satisfy  the
      withholding obligation. The period of any option will be determined by the
      Administrator,  but no option may be exercised after the expiration of ten
      years  from the date it is  granted.  Option  awards  will  provide  rules
      covering the time of exercise of an option in case of  retirement,  death,
      disability, or other termination of employment

            Stock  Appreciation  Rights.  The 2004 Plan  permits the granting of
      stock  appreciation  rights  in  conjunction  with  all or part of a stock
      option  granted  under the Plan.  In the case of a NSO, such rights may be
      granted  either at or after the date of grant of such Option.  In the case
      of an ISO,  such  rights may be granted  only at the date of grant of such
      Option.  Stock  appreciation  rights will be exercisable only at such time
      and to the  extent  that the  stock  options  to  which  they  relate  are
      exercisable.  Upon exercise of a stock  appreciation  right, a Participant
      will  receive an amount equal to the product of (a) the excess of the fair
      market  value of one share of Common  Stock  over the  exercise  price per
      share specified in the related stock option times (b) the number of shares
      in  respect  of  which  the  stock  appreciation  right  shall  have  been
      exercised,  in cash, shares of Common Stock or both, with the Compensation
      Committee having the right to determine the form of payment.


                                       22


            Dividend  Equivalent  Rights. The 2004 Plan permits the Compensation
      Committee to include in any award a dividend  equivalent  right  entitling
      the  participant  to receive  amounts  equal to all or any  portion of the
      dividends  that would be paid on the shares of Common Stock covered by the
      Award if such  shares  had  been  delivered  pursuant  to the  Award.  The
      Compensation  Committee  will  determine  whether  the payment of dividend
      equivalent  rights will be made in cash,  in shares of Common  Stock or in
      another form,  whether they shall be conditioned  upon the exercise of the
      Award to which they relate, the time at which they shall be made, and such
      other terms and conditions as the Committee considers appropriate.

            Restricted  Stock Awards and Restricted  Stock Units.  The 2004 Plan
      permits the granting of or offering for sale  restricted  shares of Common
      Stock and restricted stock units in such amounts and subject to such terms
      and conditions as the Compensation  Committee may determine.  Upon receipt
      of restricted  shares of Common Stock, the participant has the rights of a
      shareholder  with  respect  to  the  restricted  stock,   subject  to  any
      restrictions and conditions that the Compensation Committee may impose. On
      the delivery date of a restricted stock unit, the participant receives one
      share of Common Stock or cash equal in value to a share of Common Stock or
      a combination thereof, as specified by the Compensation Committee. No more
      than a total of  8,000,000  shares  of  Common  Stock  are  available  for
      delivery as restricted stock and restricted stock units.

            Other  Stock-Based  Awards.  The 2004 Plan permits the  Compensation
      Committee to grant other types of  equity-based or  equity-related  awards
      (including  the grant or offer for sale of  unrestricted  shares of Common
      Stock) in such  amounts  and subject to such terms and  conditions  as the
      Compensation Committee may determine.  Such awards may entail the transfer
      of actual  shares of Common  Stock to  participants  or payment in cash or
      otherwise of amounts based on the value of shares of Common Stock.

            Incentive Awards.  The 2004 Plan permits the Compensation  Committee
      to grant  Incentive  Awards in such amounts and subject to the achievement
      of  performance  goals and other terms and conditions as the Committee may
      determine.  Incentive  awards will be granted and  administered  to comply
      with the  requirements  of Section 162(m) of the Code.  After the term for
      the  applicable  performance  period has ended,  the  participant  will be
      entitled to payment based on the level of achievement  of the  performance
      goals set by the Compensation Committee.  The Compensation Committee shall
      certify the  achievement  of the  performance  goals in wiritng before the
      incentive  award  is  settled.  At  the  discretion  of  the  Compensation
      Committee,  the settlement of incentive  awards may be in cash,  shares of
      Common Stock, or in some combination thereof.

            Tax  Offset  Bonuses.  The  Compensation  Committee  may  grant to a
      participant  specified amount for the purpose of assisting the participant
      to pay taxes resulting from the grant of an Award.

      Change in Control.  The Committee  may provide in any award  agreement for
provisions relating to a "change in control" of the Company, including,  without
limitation, the acceleration or extension of the exercisability of, or the lapse
of restrictions or deemed satisfaction of goals with respect to, any outstanding
Awards.  Unless otherwise  provided in a participant's  award agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of the  Company  with  or  into  any  other  entity  (the
"successor  entity")  or any  transaction  in which  another  person  or  entity
acquires all of the Company's  issued and  outstanding  Common Stock, or all, or
substantially all, of the Company's assets, outstanding Awards may be assumed or
an equivalent  Award may be substituted  by the successor  entity or a parent or
subsidiary of the successor entity.

      Amendment  of the  2004  Plan.  The  Board  may from  time to time  alter,
suspend,  discontinue,  revise,  amend or terminate the 2004 Plan in any respect
whatsoever, provided, that no such modification of the 2004 Plan shall adversely
affect in any material  way any award  previously  granted  under the 2004 Plan,
without the written consent of the participant who received such award. However,
the Board may not  amend,  without  stockholder  approval,  the 2004 Plan in any
manner  that  requires   stockholder  approval  pursuant  to  the  Code  or  the
regulations  promulgated  thereunder,  or pursuant to the  Exchange  Act or Rule
16b-3 (or its successor) promulgated thereunder.


                                       23


      Term of the 2004 Plan. Unless  terminated  earlier as provided in the 2004
Plan, the 2004 Plan will expire ten years from its effective  date,  which shall
be the date on which it is approved by the Company's stockholders.

CERTAIN FEDERAL INCOME TAX CONSEQUENCES

      The following  summary of federal  income tax  consequences  is based upon
existing statutes, regulations and interpretations thereof. The applicable rules
are complex,  and income tax consequences may vary depending upon the particular
circumstances of each plan participant.  This Proxy Statement  describes federal
income  tax  consequences  of  general  applicability,  but does not  purport to
describe either  particular  consequences to each individual plan participant or
foreign,  state or local  income tax  consequences,  which may  differ  from the
United States federal income tax consequences.

      INCENTIVE STOCK OPTIONS ("ISOS")

      Award; Exercise. ISOs are intended to constitute "incentive stock options"
within  the  meaning  of Section  422 of the Code.  ISOs may be granted  only to
employees  of the  Company  (including  directors  who are also  employees).  An
optionee does not recognize  taxable income upon either the grant or exercise of
an ISO.  However,  the excess of the fair market  value of the shares  purchased
upon exercise over the option exercise price (the "option spread") is includible
in the optionee's  "alternative minimum taxable income" ("AMTI") for purposes of
the alternative minimum tax ("AMT").  The option spread is generally measured on
the date of exercise and is includible in AMTI in the year of exercise.  Special
rules  regarding the time of AMTI  inclusion  may apply for shares  subject to a
repurchase right or other  "substantial risk of forfeiture"  (including,  in the
case of each person subject to the reporting  requirements  of Section 16 of the
Exchange Act, any limitations on resale of shares imposed under Section 16(b) of
the Exchange Act).


      Sale of Option Shares.  If an optionee holds the shares purchased under an
ISO for at least two years  from the date the ISO was  granted  and for at least
one year from the date the ISO was exercised, any gain from a sale of the shares
other than to the  Company is taxable as  long-term  capital  gain.  Under these
circumstances,  the Company would not be entitled to a tax deduction at the time
the ISO was  exercised or at the time the stock was sold. If an optionee were to
dispose of stock  acquired  pursuant  to an ISO  before the end of the  required
holding periods (a "Disqualifying Disposition"),  the amount by which the market
value of the stock at the time the ISO was exercised exceeded the exercise price
(or,  if less,  the  amount of gain  realized  on the sale)  would be taxable as
ordinary  income,  and the  Company  would be entitled  to a  corresponding  tax
deduction.  Such income is subject to information reporting  requirements.  Gain
from a  Disqualifying  Disposition  in  excess  of  the  amount  required  to be
recognized as ordinary  income is capital gain, and is  "long-term"  gain if the
shares have been held more than one year as of the date of sale.  Optionees  are
required  to notify  the  Company  immediately  prior to making a  Disqualifying
Disposition.  If stock is sold to the Company rather than to a third party,  the
sale may not produce  capital gain or loss. A sale of shares to the Company will
constitute  a redemption  of such  shares,  which could be taxable as a dividend
unless the redemption is "not  necessarily  equivalent to a dividend" within the
meaning of the Code.


      Exercise with Stock. If an optionee pays for ISO shares with shares of the
Company  acquired  under an ISO or a  qualified  employee  stock  purchase  plan
("statutory option stock"), the tender of shares is a Disqualifying  Disposition
of the  statutory  option  stock if the above  described  (or other  applicable)
holding periods respecting those shares have not been satisfied.  If the holding
periods with respect to the statutory option stock are satisfied,  or the shares
were not  acquired  under a  statutory  stock  option of the  Company,  then any
appreciation  in the  value  of the  surrendered  shares  is  not  taxable  upon
surrender.  Special basis and holding period rules apply where  previously owned
stock is used to exercise an ISO.


      The present position of the Internal Revenue Service ("IRS") appears to be
that income and employment  withholding  taxes are not imposed upon the exercise
of an ISO or the sale of ISO shares.  The IRS is studying  this position and may
change it at any time, possibly with retroactive effect.

      NON-QUALIFIED STOCK OPTIONS (NSOS) AND STOCK APPRECIATION RIGHTS

      Award;  Exercise.  The  grant of  non-qualified  stock  options  and stock
appreciation rights will not result in income taxable to the employee or provide
a deduction  to the Company.  However,  the  exercise of a  non-qualified  stock
option or a stock  appreciation  right results in taxable  income to the holder,
and the  Company is entitled to a  corresponding  deduction.  At the time of the
exercise  of a  non-qualified  stock  option,  the  amount  so  taxable  and  so
deductible  will be the excess of the fair market value of the shares  purchased
over their option price.  Upon the exercise of a stock  appreciation  right, the
participant will be taxed at ordinary income tax rates on the amount of the cash
and the fair  market  value of the  shares  received  by the  employee,  and the
Company will be entitled to a corresponding deduction.


                                       24


      Sale of Option  Shares.  Upon sale,  other than to the Company,  of shares
acquired under an NSO, an optionee generally will recognize capital gain or loss
to the extent of the  difference  between the sale price and the  optionee's tax
basis in the  shares,  which will be  long-term  gain or loss if the  employee's
holding period in the shares is more than one year. Certain lower rates apply if
the shares  have been held for longer  periods.  If stock is sold to the Company
rather than to a third party,  the sale may not produce  capital gain or loss. A
sale of shares to the Company will constitute a redemption of such shares, which
could be  taxable  as a  dividend  unless  the  redemption  is "not  necessarily
equivalent to a dividend" within the meaning of the Code.


      Exercise  with Stock.  If an optionee  tenders  Common  Stock  (other than
statutory option  stock--see  above) to pay all or part of the exercise price of
an NSO, the  optionee  will not have a taxable  gain or  deductible  loss on the
surrendered  shares.  Instead,  shares  acquired upon exercise that are equal in
value to the fair market value of the shares  surrendered in payment are treated
as if they had been  substituted  for the  surrendered  shares,  taking as their
basis and holding  period the basis and holding  period that the optionee had in
the surrendered shares. The additional shares are treated as newly acquired, are
taxable to the  optionee,  and have a basis equal to their fair market  value on
the exercise date.


      If the  surrendered  shares are statutory  option stock as described above
under  "Incentive Stock Options",  with respect to which the applicable  holding
period  requirements for favorable  income tax treatment have not expired,  then
the newly acquired  shares  substituted  for the statutory  option shares should
remain subject to the federal income tax rules governing the surrendered shares,
but the  surrender  should not  constitute a  Disqualifying  Disposition  of the
surrendered stock.

RESTRICTED STOCK AWARDS AND RESTRICTED STOCK UNITS

      Award;  Exercise.  A  participant  who is  granted a  restricted  award or
restricted  stock unit will not  recognized  taxable  income upon the receipt of
such shares or stock units so long as the interest in such shares or stock units
is subject to a "substantial  risk of forfeiture"  within the meaning of Section
83 of the Code.  Upon lapse or release of the  restrictions,  the recipient will
recognize  taxable income at ordinary income tax rates on an amount equal to the
fair market value of the shares or stock units less the amount of any price paid
for the shares or stock units.  The Company will be entitled to a  corresponding
deduction  when the value of the award is  included in the  recipient's  taxable
income.  The basis of  restricted  shares or  restricted  stock units held after
lapse or termination of restrictions will be equal to their fair market value on
the  date  of  lapse  or  termination  of  restrictions,   and  upon  subsequent
disposition  any further gain or loss will be long-term  or  short-term  capital
gain or loss,  depending  upon the length of time the shares or stock unites are
held. A  participant  may elect to be taxed at ordinary  income tax rates on the
full fair market value of the restricted shares or restricted stock units at the
time of transfer.  If the election is not made, the basis of the shares or stock
units  so  acquired  will be  equal  to the  fair  market  value  at the time of
transfer.  If the election is made,  no tax will be payable upon the  subsequent
lapse or release of the restrictions, and any gain or loss upon disposition will
be a capital gain or loss.

      OTHER STOCK BASED AWARDS AND INCENTIVE AWARDS

Award;  Exercise.  A  participant  will realize  ordinary  income as a result of
performance awards at the time Common Stock is transferred or cash is paid in an
amount equal to the value of the shares delivered plus the cash paid.

OPTION GRANTS CONTINGENT UPON STOCKHOLDER APPROVAL OF THE 2004 PLAN

      Subject to stockholder  approval of this Proposal 2, on February 24, 2004,
when the market  price of  Calypte's  common  stock was  $0.585  per share,  the
Compensation  Committee of the Company's Board of Directors  granted to seven of
the Company's officers and key employees options under the 2004 Plan to purchase
an  aggregate  of  18,000,000  shares of Common  Stock at an  exercise  price of
$0.585.  Upon approval of the 2004 Plan, the options will be deemed to have been
granted on the effective  date of the 2004 Plan.  The grants may result in a per
share non-cash charge to compensation expense for an amount equal to the excess,
if any, of the fair market value of the Company's common stock on the grant date
and the $0.585  exercise  price.  The options will be exercisable 50% upon grant
and 50% on the one year  anniversary of the grant. The following table shows the
number  of  shares to be  granted  to the  current  Named  Executives  and other
employees upon approval of Proposal 2.


                                       25


                                                              NUMBER OF
     NAME AND POSITION                                          SHARES
     -----------------                                          ------

Anthony J. Cataldo                                            5,000,000
   Executive Chairman of the Board

J.  Richard George                                            5,000,000
   Chief Executive Officer and President

Richard D. Brounstein                                         1,500,000
    Executive Vice President and
    Chief Financial Officer

Non-Executive Employee Group                                  6,500,000
                                                             ----------
      Total                                                  18,000,000
                                                             ==========

APPROVAL REQUIRED

      Approval of Proposal 2 requires the affirmative  vote of a majority of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.

      THE BOARD UNANIMOUSLY RECOMMENDS A VOTE FOR THE APPROVAL OF THE 2004 PLAN.
PROXIES  SOLICITED BY THE BOARD WILL BE SO VOTED UNLESS  STOCKHOLDERS  SPECIFY A
DIFFERENT CHOICE IN THEIR PROXIES.


               RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS
                                  (PROPOSAL 3)


      The  Audit  Committee  of the  Board  has  recommended  and the  Board has
appointed the accounting firm of Odenberg Ullakko Muranishi & Co. LLP ("OUM") as
independent  auditors to audit the  financial  statements of the Company for the
fiscal year ending December 31, 2004. OUM has been so engaged since December 24,
2003. Additional  information concerning the engagement of OUM and the dismissal
of the Company's previous certified public accountants, KPMG LLP may be found in
the Audit Committee Report on pages 14 to 15 above.


      Representatives  from OUM are expected to be at the Annual  Meeting and to
be available to respond to appropriate questions. Such representatives will have
the  opportunity  to make a statement  if they desire to do so and to respond to
appropriate questions raised during the meeting.


APPROVAL REQUIRED

      Approval of Proposal 3 requires the affirmative  vote of a majority of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.


      THE  BOARD  UNANIMOUSLY  RECOMMENDS  A VOTE  FOR THE  RATIFICATION  OF THE
APPOINTMENT OF OUM AS INDEPENDENT  AUDITORS TO AUDIT THE FINANCIAL STATEMENTS OF
THE COMPANY FOR THE FISCAL YEAR ENDING DECEMBER 31, 2004.  PROXIES  SOLICITED BY
THE BOARD WILL BE SO VOTED  UNLESS  STOCKHOLDERS  SPECIFY A DIFFERENT  CHOICE IN
THEIR PROXIES.



                                  OTHER MATTERS


DEADLINE FOR RECEIPT OF  STOCKHOLDER  PROPOSALS  FOR  INCLUSION IN THE COMPANY'S
PROXY STATEMENT FOR THE 2005 ANNUAL MEETING

      Under the rules of the  Securities  and Exchange  Commission,  stockholder
proposals  submitted  for next year's  Proxy  Statement  must be received by the
Company  no later  than  the  close of  business  on  February  7,  2005,  to be
considered.  Proposals should be addressed to Jerrold Dotson, Secretary, Calypte
Biomedical Corporation, 1265 Harbor Bay Parkway, Alameda, California 94502.


                                       26


      Any  stockholder  who  wishes  to  bring a  proposal  before  the  Calypte
Biomedical Corporation 2005 Annual Meeting of Stockholders, but does not wish to
include it in the Company's proxy materials,  must provide written notice of the
proposal to Calypte's Secretary, at the above address, by March 10, 2005.


OTHER INFORMATION

      The Company does not know of any matters  other than those  referred to in
the accompanying Notice of Annual Meeting of Stockholders that may properly come
before the meeting or other matters  incident to the conduct of the meeting.  As
to any other  matter or proposal  that may  properly  come  before the  meeting,
including  voting for the  election  of any  person as a director  in place of a
nominee  named  herein  who  becomes  unable to serve or for good cause will not
serve and voting on a proposal omitted from this Proxy Statement pursuant to the
rules of the  Securities  and Exchange  Commission,  it is intended that proxies
received will be voted in accordance with the discretion of the proxy holders.

      There are no matters on the agenda that  involve  rights of appraisal of a
stockholder.  The  Company  incorporates  by  reference  all items  and  matters
contained  in its Form  10-KSB for the Fiscal  Year ended  December  31, 2003 as
filed with the  Securities  and  Exchange  Commission  in  addition  to its Form
10-QSBs and Form 8-K Reports as filed with the Commission.


                                         By order of the Board of Directors,

                                         /s/ J. Richard George
                                         J. Richard George
                                         President and Chief Executive Officer


Alameda, California
May 3, 2004


                                       27


                                                                      APPENDIX A


                         CALYPTE BIOMEDICAL CORPORATION
                             AUDIT COMMITTEE CHARTER
                            ADOPTED JANUARY 19, 2004

INTRODUCTION

The Audit Committee of the Board of Directors of Calypte Biomedical  Corporation
(the  "Company")  assists the Board of Directors  in  fulfilling  its  oversight
responsibilities   relating  to  the  integrity  of  the  financial  statements,
compliance with legal and regulatory  requirements,  the  independent  auditor's
qualifications and independence, the performance of the independent auditor, and
such other duties as directed by the Board of Directors.

While the Audit Committee has the  responsibilities and powers set forth in this
Charter, it is not the duty of the Audit Committee to plan or conduct audits, to
prepare the Company's  financial  statements or to determine  that the Company's
financial  statements  and  disclosures  are  complete  and  accurate and are in
accordance with generally  accepted  accounting  principles and applicable rules
and  regulations.   These  are  the   responsibilities  of  management  and  the
independent auditor.

STRUCTURE AND ORGANIZATION

      1.  The  committee  will be  composed  solely  of  directors  who have the
necessary  experience  and are  independent of the management of the company and
are  free  of any  relationship  that  may  interfere  with  their  exercise  of
independent  judgment  as  a  committee  member,  all  in  accordance  with  the
Securities Exchange Act of 1934, as amended,  (the "Exchange Act") of the United
States  Securities and Exchange  Commission ("SEC) and applicable stock exchange
requirements.

      2. The  committee  will consist of at least three  members of the Board of
Directors.  Committee  members and the committee  chair serve at the pleasure of
the Board of Directors.  All members must be or become financially  literate, at
least one member must have accounting or related financial  management expertise
sufficient to be financially  sophisticated  as required by the applicable stock
exchange rules, and, if required by the Board of Directors,  at least one member
must be an "audit committee financial expert" as defined by SEC rules.

      3. A committee  member  invited to sit on another public  company's  audit
committee must notify the committee. The committee must determine whether or not
the committee  member's service on another company's audit committee impairs the
directors' ability to serve on the Company's audit committee.

      4. The  committee  will meet at least  four times a year,  on a  quarterly
basis,  or more  frequently  as  circumstances  require.  The  committee may ask
members of  management  or others to attend the meetings  and provide  pertinent
information  as  necessary.  Meetings  may be in person or by video or telephone
conference  if  necessary.  Special  meetings  may be  called  by the  Company's
Executive Chairman or by any member of the committee.  A majority of the members
shall constitute a quorum.

      5. The committee is expected to maintain free and open  communication with
management and the independent auditor.

      6. The committee has the authority to  investigate  any matter  brought to
its attention and to retain independent legal,  accounting or other advisors for
this  purpose  or any  other  purpose  if  determined  appropriate,  in its sole
judgment. The Company will provide funding for that purpose as determined by the
committee.

The committee's responsibilities include:


                                       28


GENERAL RESPONSIBILITIES

      1. Meet at least quarterly with the independent  auditor and management in
separate  sessions to discuss any matters  that the  committee  or these  groups
believe should be discussed  privately with the  committee.  Provide  sufficient
opportunity  for the  independent  auditor to meet with others in the Company as
appropriate.

      2. Prepare and submit the minutes of all committee  meetings and regularly
report to the Board of Directors on committee matters.

      3. Review and reassess  the adequacy of this Charter  annually and propose
to the Board of Directors any changes to the Charter.

      4. Set policies for the Company's  hiring of employees or former employees
of the independent  auditor who participated in any capacity in the audit of the
company.

      5. Prepare a report of the committee in accordance  with SEC  requirements
to be included in the Company's annual proxy statement.

RESPONSIBILITIES RELATED TO THE INDEPENDENT AUDITOR

      1. Appoint and retain and, where  appropriate,  terminate the  independent
auditor.  Approve the compensation of the independent  auditor, and evaluate the
performance of the independent  auditor.  The  independent  auditor shall report
directly to the  committee.  The  committee  shall be directly  responsible  for
oversight  of the  work of the  independent  auditor  (including  resolution  of
disagreements between management and such firm regarding financial reporting.)

      2. Review with the  independent  auditor and  management the audit plan of
the independent auditor for the current year and the following year.

      3. Establish a policy with respect to the evaluation and approval of audit
and  permitted  non-audit  services  and  related  fees to be  performed  by the
independent  auditor in accordance with the applicable laws and  requirements of
the applicable stock exchange.

      4. On an annual  basis,  discuss and  consider the  independent  auditor's
written  affirmation  that the auditor is in fact  independent.  Obtain a formal
written  statement from the independent  auditor  delineating all  relationships
between the Company and the  independent  auditor,  actively  engage in dialogue
regarding  disclosed  relationships or services which may impact the objectivity
and  independence  of the  independent  auditor,  and take or recommend that the
Board of Directors take appropriate  action in response to the outside auditor's
report to satisfy itself of the outside  auditor's  independence.  The committee
will  evaluate  the   qualifications,   performance  and   independence  of  the
independent auditor and present its conclusions to the Board of Directors.

      5. At the committee's  discretion,  arrange for the independent auditor to
be  available  to the full Board of  Directors  to help  provide a basis for the
Board of Directors' approval of the independent auditor's appointment.

      6. Review with the independent auditor the matters relating to the conduct
of the audit,  including any problems or difficulties  encountered in the course
of the audit work,  any  restrictions  on the scope of  activities  or access to
requested information and any significant disagreements with management.

RESPONSIBILITIES  FOR  OVERSIGHT  OF THE QUALITY AND  INTEGRITY  OF  ACCOUNTING,
AUDITING AND REPORTING PRACTICES OF THE COMPANY

      1. Review and discuss with management and the independent auditor prior to
filing  with the SEC in  periodic  reports  the annual and  quarterly  financial
statements, including disclosures under "Management's Discussion and Analysis of
Financial  Condition and Results of Operations"..  The committee should meet and
discuss each quarterly earnings  announcement,  as well as financial information
and earnings guidance provided to analysts, with management (and the independent
auditor, if desired) prior to release. The discussion may be done generally, and
may  include  the  types  of  information  to be  disclosed  and  the  types  of
presentations to be made. These  discussions  should cover the quality (not just
the  acceptability)  of the financial  reporting,  and such other matters as the
committee deems appropriate.


                                       29


      2. Review with management and the independent  auditor critical accounting
policies,   significant   financial  reporting  issues  and  judgments  made  in
connection with the preparation of the company's financial statements, including
any significant  changes in the company's selection or application of accounting
principles.

      3. As necessary,  discuss with management any  significant  financial risk
exposure  and the  steps  management  has  taken to  monitor  and  control  such
exposures, including the company's risk assessment and risk management policies.

1.  Review  with  management  and  the  independent  auditor  the  adequacy  and
effectiveness  of the company's  disclosure  controls and  procedures,  internal
controls for financial reporting and computerized information systems controls.

PERIODIC RESPONSIBILITIES

      1. Review with management any legal and regulatory matters that may have a
material impact on the company's financial  statements,  compliance policies and
compliance programs.

      2. Oversee the Company's  Corporate  Compliance  Program and  periodically
review and suggest to  management  any  necessary  improvements  in the program.
Establish  procedures  within  the  Corporate  Compliance  Program  for  the (i)
receipt,  retention and treatment of complaints regarding  accounting,  internal
accounting  controls  or  auditing  matters,  and (ii)  confidential,  anonymous
submission  by  employees  of  concerns  regarding  questionable  accounting  or
auditing matters and other matters under the company's Code of Business Conduct.

      3. Act as the Company's Qualified Legal Compliance  Committee ("QLCC") for
purposes of internal and external  attorney  reporting  under Section 307 of the
Sarbanes-Oxley  Act of 2002.  Establish a procedure  for  confidential  receipt,
retention and consideration of any attorney report to the QLCC.

      4. Review and approve  transactions with the Company involving  management
and/or  members of the Board of Directors and other  related party  transactions
which are not otherwise  subject to the approval of the  Compensation  Committee
and would require disclosure under SEC or applicable stock exchange rules.

      5. Obtain  assurance from the  independent  auditor that Section 10A(b) of
the Exchange Act has not been implicated.

      6. Discuss with management and the independent  auditor any correspondence
with regulators or governmental  agencies and any published  reports which raise
material  issues  regarding  the  Company's  financial  statements or accounting
policies.

      7. Annually assess the committee's performance.

      8. Perform such other functions assigned by law, applicable stock exchange
requirements, the Company's charter or bylaws or the Board of Directors.



                                       30


                                                                      APPENDIX B

                         CALYPTE BIOMEDICAL CORPORATION
                         COMPENSATION COMMITTEE CHARTER
                             AS OF JANUARY 19, 2004

The  Compensation  Committee  of the Board of  Directors  of Calypte  Biomedical
Corporation  (the  "Company")  assists the Board of Directors in fulfilling  its
oversight  responsibilities  relating  to  officer  and  director  compensation,
succession  planning for senior management,  development and retention of senior
management, and such other duties as directed by the Board of Directors.

STRUCTURE AND ORGANIZATION

      1. The committee will be composed  solely of directors who are independent
of the  management  of the  company  and are free of any  relationship  that may
interfere with their exercise of independent judgment as a committee member, all
in accordance with United States Securities and Exchange  Commission ("SEC") and
applicable  stock  exchange  requirements,  and also  meet the  requirements  of
Section 16 of the Securities  and Exchange Act of 1934, as amended,  and Section
162(m) of the Internal Revenue Code of 1986, as amended..

      2. The  committee  will  consist  of at least two  members of the Board of
Directors.  Committee  members and the committee  chair serve at the pleasure of
the Board of Directors.

      3. The committee will meet at least annually, or more frequently as deemed
appropriate. The committee may ask members of management or others to attend the
meetings and provide pertinent information as necessary.  Meetings are generally
held in  person  but  may  also be held by  video  or  telephone  conference  if
necessary. Special meetings may be called by the Company's Executive Chairman or
by any member of the  committee.  A majority of the members  shall  constitute a
quorum.

      4. The committee has the authority to retain and terminate any  consulting
firm used to assist in the evaluation of director,  chief  executive  officer or
other officer compensation and to retain independent legal or other advisors, in
each case as the  committee  may deem  appropriate,  including  the authority to
approve these firm's fees and other retention terms.

      5.  The   committee   or  the  Board  of   Directors   may   reassign  the
responsibilities of this committee to a subcommittee or another committee of the
Board of  Director's  choosing as long as the  committee  is made up entirely of
independent directors.

The committee's responsibilities include:

GENERAL RESPONSIBILITIES

      1. Prepare and submit the minutes of all committee  meetings and regularly
report to the Board of Directors on committee matters.

      2. Review and reassess  the adequacy of this Charter  annually and propose
to the Board of Directors any changes to the Charter.

      3.  Prepare  a  report  of the  committee  on  executive  compensation  in
accordance with SEC  requirements  to be included in the Company's  annual proxy
statement.

      4. Annually assess the committee's performance.

      5. Perform such other functions assigned by law, applicable stock exchange
requirements, the Company's charter or bylaws or the Board of Directors.


                                       31


RESPONSIBILITIES RELATED TO COMPENSATION

      1. Review and approve the Company's compensation guidelines and structure.

      2.  Review  and  approve  on an  annual  basis  the  corporate  goals  and
objectives with respect to compensation for the executive chairman and the chief
executive  officer.  The  committee  will  evaluate  at least  once a year their
individual  performance in light of these  established  goals and objectives and
based upon these  evaluations  shall set their  annual  compensation,  including
salary,  bonus,  incentive and equity  compensation.  These  officers may not be
present when their compensation is considered or determined by the committee.

      3.  Review  and  approve on an annual  basis the  evaluation  process  and
compensation  structure  for the Company's  other  officers,  including  salary,
bonus,  incentive and equity compensation.  The committee will evaluate at lease
once a year their individual performance in light of these established goals and
objectives   and,  based  upon  their   evaluations,   shall  set  their  annual
compensation.

      4. Review the  Company's  incentive  compensation  and other  equity-based
plans and  recommend  changes in such plans to the Board of Directors as needed.
The committee may exercise the authority of the Board of Directors  with respect
to the administration of such plans.

      5. Periodically review and make  recommendations to the Board of Directors
regarding the  compensation  of  non-management  directors,  including Board and
committee retainers,  meeting fees,  equity-based  compensation,  and such other
forms of compensation and benefits as the committee may consider appropriate.

      6. Oversee the appointment and removal of executive  officers.  Review and
approve for executive  officers,  including the executive chairman and the chief
executive officer, any employment, severance or change in control agreements.

      7. Approve any loans to employees as allowed by law.


                                       32


                                                                      APPENDIX C

                         CALYPTE BIOMEDICAL CORPORATION
                          NOMINATING COMMITTEE CHARTER
                             AS OF JANUARY 19, 2004

The  Nominating  Committee  of the  Board of  Directors  of  Calypte  Biomedical
Corporation  (the  "Company")  assists the Board of Directors in fulfilling  its
oversight  responsibilities  relating  to  the  company's  corporate  governance
matters,  periodic  evaluation of the Board of  Directors,  its  committees  and
individual  directors,  identification and selection of director  nominees,  and
such other duties as directed by the Board of Directors.

STRUCTURE AND ORGANIZATION

      1. The committee will be composed  solely of directors who are independent
of the  management  of the  company  and are free of any  relationship  that may
interfere with their exercise of independent judgment as a committee member, all
in  accordance  with  United  States  Securities  and  Exchange  Commission  and
applicable stock exchange requirements.

      2. The  committee  will  consist  of at least two  members of the Board of
Directors.  Committee  members and the committee  chair serve at the pleasure of
the Board of Directors.

      3. The committee will meet at least annually, or more frequently as deemed
appropriate. The committee may ask members of management or others to attend the
meetings and provide pertinent information as necessary.  Meetings are generally
held in  person  but  may  also be held by  video  or  telephone  conference  if
necessary. Special meetings may be called by the Company's Executive Chairman or
by any member of the  committee.  A majority of the members  shall  constitute a
quorum.

      4. The committee has the authority to retain and terminate any search firm
used to identify  director  candidates and to retain  independent legal or other
advisors,  in each case as the  committee  may deem  appropriate,  including the
authority to approve these firm's fees and other retention terms.

      5.  The   committee   or  the  Board  of   Directors   may   reassign  the
responsibilities of this committee to a subcommittee or another committee of the
Board of  Director's  choosing as long as the  committee  is made up entirely of
independent directors.

The committee's responsibilities include:

GENERAL RESPONSIBILITIES

      1. Prepare and submit the minutes of all committee  meetings and regularly
report to the Board of Directors on committee matters.

      2. Review and reassess  the adequacy of this Charter  annually and propose
to the Board of Directors any changes to the Charter.

1.    Perform such other functions  assigned by law,  applicable  stock exchange
      requirements, the company's charter or bylaws or the Board of Directors.

RESPONSIBILITIES RELATED TO CORPORATE GOVERNANCE

1.    Develop  and  recommend  to  the  Board  of  Directors  for  its  approval
      guidelines and criteria for selecting new directors, enabling stockholders
      to send  communications to the Board of Directors and director  attendance
      at annual meetings of stockholders.


                                       33



2.    Review from time to time the Board of Directors'  committee  structure and
      recommend to the Board of Directors for its approval directors to serve as
      members of each committee.

3.    Develop and  recommend to the Board of Directors for its approval a set of
      corporate  governance   guidelines.   The  Committee  shall  review  these
      guidelines  regularly,  and at least  annually,  and recommend  changes as
      necessary or appropriate.

4.    Monitor  the  independence  of the  Board of  Directors,  assure  that the
      majority of the Board of Directors  continues to be independent and review
      any potential conflict of interest between a director and the Company.

RESPONSIBILITIES RELATED TO BOARD CANDIDATES AND NOMINEES

      1. Lead searches for qualified  candidates to become  members of the Board
of Directors and evaluate, select, and approve director nominees to be appointed
by the Board of  Directors or  presented  for approval at the annual  meeting of
stockholders.

2.    Nominate directors consistent with the guidelines and criteria approved by
      the  Board  of  Directors  for  selecting  new  directors,  including  the
      Company's policy regarding director independence.

      3.  Develop and  recommend  to the Board of  Directors  for its approval a
policy  regarding the  consideration of any director  candidates  recommended by
stockholders.

RESPONSIBILITIES RELATED TO BOARD EVALUATION

      1. At least annually, review and assess the composition and performance of
the Board of Directors,  each  committee,  including  this  committee,  and each
individual director.



                                       34


                                                                      APPENDIX D

                       THE CALYPTE BIOMEDICAL CORPORATION
                               2004 INCENTIVE PLAN

                                    ARTICLE I

                                     GENERAL

1.1   PURPOSE.

      The purpose of The Calypte  Biomedical  Corporation 2004 Incentive Plan is
to attract,  retain and  motivate  officers,  employees  (including  prospective
employees),  consultants and others who may perform services for the Company, to
compensate them for their  contributions  to the long-term growth and profits of
the Company,  and to  encourage  them to acquire a  proprietary  interest in the
success of the Company.

1.2   DEFINITIONS OF CERTAIN TERMS.

      1.2.1 "Award" means an award made pursuant to the Plan.

      1.2.2 "Award  Agreement" means the written document by which each Award is
evidenced.

      1.2.3 "Board" means the Board of Directors of Calypte.

      1.2.4 " Calypte" means Calypte Biomedical  Corporation,  and any successor
thereto.

      1.2.5  "Cause"  means the causes set forth in any  written  employment  or
services  agreement  between  the Company and the  grantee,  if any,  or, in the
absence of such an agreement,  means any of the following acts or circumstances:
(i) willful  destruction  by the grantee of Company  property  having a material
value to the Company; (ii) fraud,  embezzlement,  theft, or comparable dishonest
activity  committed by the grantee against the Company;  (iii) the Participant's
conviction  of or  entering  a plea of  guilty or nolo  contendere  to any crime
constituting a felony or any misdemeanor  involving  fraud,  dishonesty or moral
turpitude;  (iv) the grantee's breach, neglect, refusal or failure to discharge,
in each case in any  material  respect,  his or her  duties  (other  than due to
Disability) commensurate with his or her title and function or failure to comply
with the lawful  directions of the Board; or (v) a willful and knowing  material
misrepresentation by the grantee to the Board.

      1.2.6  "Certificate"  means  a stock  certificate  (or  other  appropriate
document  or  evidence  of  ownership)  representing  shares of Common  Stock of
Calypte.

      1.2.7 "Code" means the Internal Revenue Code of 1986, as amended from time
to time, and the applicable rulings and regulations thereunder.

      1.2.8  "Committee"  means the  Compensation  Committee of the Board or any
successor  thereto or such other  committee or  subcommittee  designated  by the
Board to administer the Plan in accordance with Section 1.3.

      1.2.9  "Common  Stock" means common stock of Calypte,  par value $0.03 per
share.

      1.2.10 "Company" means Calypte.

      1.2.11 "Disability" means, unless otherwise defined in an Award Agreement,
or as otherwise  determined  under  procedures  established by the Committee for
purposes of the Plan, a disability within the meaning of Section 22(e)(3) of the
Code.

                                       35


      1.1.12  "Employment"  means a grantee's  performance  of services  for the
Company, as determined by the Committee. The terms "employ" and "employed" shall
have their correlative meanings.

      1.2.13  "Exchange  Act"  means the  Securities  Exchange  Act of 1934,  as
amended from time to time, and the applicable rules and regulations thereunder.

      1.2.14  "Fair Market  Value"  means,  as of any date,  the value of Common
Stock determined as follows:

            1.2.14.1  If the  Common  Stock is listed on any  established  stock
      exchange, the NASDAQ System or a national market system, including without
      limitation, the National Market System of NASDAQ, the Fair Market Value of
      a share of Common Stock will be the closing sales price for such stock (or
      the  closing  bid, if no sales are  reported)  as quoted on that system or
      exchange (or the system or exchange with the greatest volume of trading in
      Common Stock) on the day of determination,  as reported in the Wall Street
      Journal or any other source the Committee considers reliable.

            1.2.14.2 If the Common Stock is not traded as set forth  above,  the
      Fair Market Value will be determined in good faith by the Committee,  such
      determination by the Committee to be final, conclusive and binding.

      1.2.15 "Grant  Notice" means the written notice  evidencing  certain terms
and conditions of an Award. The Grant Notice is part of the Award Agreement.

      1.2.16  "Incentive  Award"  means any Award  granted  contingently  on the
achievement of Performance Goals during Performance  Periods,  expressed in U.S.
currency  or Common  Stock or any  combination  thereof,  intended to qualify as
performance-based  compensation  pursuant to Section  162(m) of the Code, as now
constituted or subsequently amended, or pursuant to a successor provision of the
Code, and which is so designated in the applicable Award Agreement.

      1.2.17  "Incentive  Stock  Option"  means an Option  that is  intended  to
qualify for special  federal  income tax treatment  pursuant to Sections 421 and
422 of the Code, as now  constituted or subsequently  amended,  or pursuant to a
successor  provision of the Code,  and which is so designated in the  applicable
Award Agreement.

      1.2.18  "Nonqualified  Stock  Option"  means  an  Option  that  is  not an
Incentive Stock Option.

      1.2.19  "Option" means an Incentive  Stock Option or a Nonqualified  Stock
Option or both, as the context requires.

      1.2.20  "Performance  Goals"  means  objectives  for  the  Company  or any
individual grantee established by the Committee with respect to Incentive Awards
contingently granted under the Plan. The Performance Goals shall be based on one
or more of the  following  criteria:  earnings  (either in the aggregate or on a
per-share basis), total stockholder return, return on equity, return on capital,
net income,  cash flow,  operating  income or profit,  gross revenues,  economic
value added, or strategic business criteria.  The levels of performance required
with  respect to  Performance  Goals may be  expressed  in  absolute or relative
levels.

      1.2.21  "Performance   Period"  means  a  set  time  period  during  which
Performance Goals must be met.

      1.2.22  "Plan" means The Calypte  Biomedical  Corporation  2004  Incentive
Plan, as described herein and as hereafter amended from time to time.

      1.2.23  "Termination  of  Employment"  occurs  on the first day on which a
grantee is for any reason no longer  providing  services  to the  Company in the
capacity of an employee, officer or consultant.


                                       36



1.3   ADMINISTRATION.

      1.3.1  Subject to Section  1.3.4,  the Plan shall be  administered  by the
Board or the Committee,  whose members shall serve at the pleasure of the Board.
To the  extent  required  for  transactions  under the Plan to  qualify  for the
exemptions  available under Rule 16b-3  promulgated  under the Exchange Act, all
actions  relating to Awards to persons subject to Section 16 of the Exchange Act
may be taken by the Board or the Committee composed of two or more members, each
of whom is a  "non-employee  director"  within the meaning of Exchange  Act Rule
16b-3.  To the extent required for  compensation  realized from Awards under the
Plan to be deductible by Calypte  pursuant to Section  162(m) of the Code,  such
Awards may be granted by the Committee composed of two or more members,  each of
whom is an "outside director" within the meaning of Code Section 162(m).

      1.3.2  Subject to Section 3.1, the Committee  shall have complete  control
over the  administration  of the  Plan  and  shall  have  the  authority  in its
discretion to (a) exercise all of the powers  granted to it under the Plan,  (b)
construe,  interpret  and  implement  the Plan  and any  Award  Agreements,  (c)
prescribe,  amend  and  rescind  rules  and  regulations  relating  to the Plan,
including  rules  governing  its own  operations,  (d) make  all  determinations
necessary or advisable in administering the Plan, (e) correct any defect, supply
any omission and reconcile any  inconsistency in the Plan, (f) amend the Plan to
reflect changes in applicable law, (g) amend any outstanding  Award Agreement in
any respect,  including,  without limitation, to accelerate the time or times at
which the Award becomes vested, unrestricted or may be exercised, waive or amend
any goals,  restrictions  or conditions  set forth in such Award  Agreement,  or
impose  new  goals,  restrictions  and  conditions,  or  reflect a change in the
grantee's circumstances (e.g., a change to part-time employment status), and (h)
determine  whether,  to what extent and under what  circumstances  and method or
methods (1) Awards may be (A)  settled in cash,  shares of Common  Stock,  other
securities,  other Awards or other  property,  (B)  exercised  or (C)  canceled,
forfeited or suspended,  (2) shares of Common  Stock,  other  securities,  other
Awards or other property, and other amounts payable with respect to an Award may
be deferred either automatically or at the election of the grantee thereof or of
the  Committee,  (3) loans  (whether  or not  secured  by Common  Stock)  may be
extended by the Company with respect to any Awards and (4) Awards may be settled
by  Calypte,  any of  its  subsidiaries  or  affiliates  or any of its or  their
designees.

      1.3.3  Actions of the  Committee may be taken by the vote of a majority of
its  members.  Any  action  may be taken by a  written  instrument  signed  by a
majority  of the  Committee  members,  and  action  so  taken  shall be fully as
effective as if it had been taken by a vote at a meeting.  The  determination of
the Committee on all matters  relating to the Plan or any Award  Agreement shall
be final,  binding and conclusive.  The Committee may allocate among its members
and  delegate  to any  person  who is not a member of the  Committee  any of its
administrative responsibilities.

      1.3.4 No member  of the  Board or the  Committee  or any  employee  of the
Company shall be liable for any action or determination  made in good faith with
respect  to the  Plan  or any  Award  thereunder.  Each  such  person  shall  be
indemnified  and held  harmless  by  Calypte  against  and from any loss,  cost,
liability,  or expense  that may be imposed  upon or  incurred by such person in
connection  with or resulting from any action,  suit or proceeding to which such
person may be a party or in which such  person may be  involved by reason of any
action  taken or failure act under the Plan or any Award  Agreement  and against
and from any and all amounts paid by such person,  with Calypte's  approval,  in
settlement  thereof,  or paid by such person in  satisfaction of any judgment in
any such action,  suit or proceeding against such person,  provided that Calypte
shall have the right,  at its own  expense,  to assume and defend the same.  The
foregoing  right of  indemnification  shall not be  available to a person to the
extent  that a final  judgment  or other final  adjudication  binding  upon such
person  establishes that the acts or omissions of such person giving rise to the
indemnification  claim  resulted from such person's bad faith,  fraud or willful
criminal act or omission.  The foregoing right of  indemnification  shall not be
exclusive  of any other rights of  indemnification  to which such persons may be
entitled under Calypte's  Certificate of Incorporation or Bylaws, as a matter of
law, or  otherwise,  or any other power that Calypte may have to indemnify  such
persons or hold them harmless.

1.4   PERSONS ELIGIBLE FOR AWARDS.

      Awards under the Plan may be made to such officers,  employees  (including
prospective  employees),  consultants  and  other  individuals  who may  perform
services for the Company, as the Committee may select.

1.5   TERMINATION OF EMPLOYMENT.

      1.5.1 The  Committee may impose on any Award or the exercise or settlement
thereof,  at the date of grant or,  subject to the  provisions  of Section  3.1,
thereafter,  such  additional  terms and  conditions not  inconsistent  with the
provisions  of the  Plan  as the  Committee  shall  determine,  including  terms
requiring  forfeiture,  acceleration  or pro-rata  acceleration of Awards in the
event of a  Termination  of  Employment.  Except as otherwise  determined by the
Committee,  all Options that have not been  exercised,  or any other Awards that
remain  subject to a risk of forfeiture or which are not  otherwise  vested,  or
which have  outstanding  Performance  Periods,  at the time of a Termination  of
Employment shall be forfeited to the Company.


                                       37



      1.5.2  TERMINATION FOR CAUSE. If a grantee's  Employment is terminated for
Cause,  then all  Options  and other  Awards  that  remain  subject to a risk of
forfeiture  or  which  are not  otherwise  vested  held by  such  grantee  shall
immediately be terminated and cancelled upon Termination of Employment.

      1.5.3 DEATH,  DISABILITY,  TERMINATION  WITHOUT CAUSE. Except as otherwise
provided in the applicable Award Agreement, upon the grantee's death, Disability
or Termination of Employment for any reason other than for Cause, the grantee:

            1.5.3.1 shall forfeit all Awards that have not previously  vested or
      remain subject to a risk of forfeiture;

            1.5.3.2 shall have thirty (30) days to exercise the grantee's Awards
      that are vested on the  Termination  of Employment if such  termination is
      for any reason other than the grantee's Disability or death; and

            1.5.3.3  shall have one (1) year to exercise  the  grantee's  Awards
      that are  vested  on the  date of  Disability  or  death if the  grantee's
      Termination of Employment is due to the grantee's Disability or death.

      1.5.4 TERMINATION AFTER CHANGE IN CONTROL. Except as otherwise provided by
the Committee or in the applicable Award Agreement,  if any grantee's Employment
is  terminated by the Company for any reason other than for Cause within six (6)
months after a "change in control" as defined in Section 3.7,  then all unvested
Awards and other Awards  remaining  subject to a risk of forfeiture held by such
grantee  shall  become  fully  vested  for  exercise  upon  the  Termination  of
Employment.

      1.5.5 Any Awards not exercised within the permissible period of time shall
be forfeited by the grantee.  Notwithstanding any of the foregoing,  the grantee
shall not be  permitted  to  exercise  any Option at a time  beyond the  initial
option term.

1.6   TYPES OF AWARDS UNDER PLAN.

      Awards  may be made under the Plan in the form of (a)  Options,  (b) stock
appreciation  rights, (c) dividend  equivalent rights, (d) restricted stock, (e)
restricted stock units, (f) other  equity-based or  equity-related  Awards which
the Committee  determines to be consistent  with the purpose of the Plan and the
interests of the Company,  and (g) Incentive  Awards.  No Incentive Stock Option
(other than an  Incentive  Stock Option that may be assumed or issued by Calypte
in connection  with a transaction  to which Section  424(a) of the Code applies)
may be granted to a person who is not  eligible  to receive an  Incentive  Stock
Option under the Code.

1.7   SHARES AVAILABLE FOR AWARDS.

      1.7.1 TOTAL SHARES  AVAILABLE.  Subject to adjustment  pursuant to Section
1.7.2,  the  total  number of shares  of  Common  Stock  which may be  delivered
pursuant  to  Awards  granted  under  the  Plan  shall be  30,000,000,  of which
8,000,000  shall be available  for delivery as restricted  stock and  restricted
stock units. If, after the effective date of the Plan, any Award is forfeited or
otherwise  terminated or canceled without the delivery of shares of Common Stock
or is settled for cash,  any shares of Common Stock are  surrendered or withheld
from  any  Award  to  satisfy  a  grantee's  income  tax  or  other  withholding
obligations,  or any shares of Common  Stock owned by a grantee are  tendered to
pay the  exercise  price of any Award  granted  under the Plan,  then the shares
covered by such  forfeited,  terminated or canceled  Award or which are equal to
the number of shares  settled,  surrendered,  withheld or  tendered  shall again
become available for transfer  pursuant to Awards granted or to be granted under
this Plan.

      1.7.2  ADJUSTMENTS.  The  Committee  shall  adjust the number of shares of
Common Stock authorized pursuant to Section 1.7.1 and adjust (including, without
limitation,  by payment of cash) the terms of any outstanding Awards (including,
without  limitation,  the  number  of shares of  Common  Stock  covered  by each
outstanding  Award,  the type of  property to which the Award is subject and the
exercise or strike price of any Award),  in such manner as necessary to preserve
the benefits or potential  benefits intended to be made available to grantees of
Awards,  for any  increase or decrease in the number of issued  shares of Common
Stock  resulting  from a stock  split,  reverse  stock  split,  stock  dividend,
spinoff,  splitup,  combination or  reclassification of the Common Stock, or any
other  event  the  Committee  determines  in its  sole  discretion  affects  the
capitalization of Calypte, including any extraordinary dividend or distribution.
After any adjustment  made pursuant to this Section 1.7, the number of shares of
Common Stock subject to each  outstanding  Award shall be rounded to the nearest
whole number.


                                       38



      1.7.3 MAXIMUM AWARDS.  Subject to adjustment as provided in Section 1.7.2,
(a) the maximum  number of shares of Common Stock with respect to which  Options
or stock appreciation  rights may be granted to an individual grantee during any
calendar  year shall equal  8,000,000  shares of Common  Stock,  (b) the maximum
number of shares of Common  Stock  with  respect  to which  restricted  stock or
restricted  stock  units may be  granted  to an  individual  grantee  during any
calendar year shall equal 8,000,000  shares of Common Stock, (c) the total value
of any Incentive Award awarded to an individual grantee during any calendar year
shall  not  exceed  $1,000,000.  Any  shares of Common  Stock (a)  delivered  by
Calypte,  (b) with  respect to which  Awards  are made by  Calypte  and (c) with
respect to which Calypte becomes  obligated to make Awards, in each case through
the assumption of, or in substitution for, outstanding awards previously granted
by an acquired  entity,  shall not be counted against the shares of Common Stock
available  for  Awards  under  this Plan.  Shares of Common  Stock  which may be
delivered  pursuant to Awards may be  authorized  but  unissued  Common Stock or
authorized  and issued  Common  Stock held in  Calypte's  treasury or  otherwise
acquired for the purposes of the Plan.


                                   ARTICLE II

                              AWARDS UNDER THE PLAN

2.1   AGREEMENTS EVIDENCING AWARDS.

      Each Award granted under the Plan shall be evidenced by a written document
which shall  contain such  provisions  and  conditions  as the  Committee  deems
appropriate.  The Committee  may grant Awards in tandem with or in  substitution
for any other Award or Awards granted under this Plan or any award granted under
any other plan of the Company.  By  accepting  an Award  pursuant to the Plan, a
grantee  thereby  agrees that the Award shall be subject to all of the terms and
provisions of the Plan and the applicable Award Agreement.

2.2   NO RIGHTS AS A SHAREHOLDER.

      No grantee of an Award  shall have any of the rights of a  shareholder  of
Calypte with respect to shares  subject to such Award until the delivery of such
shares.  Except as otherwise  provided in Section 1.7.2, no adjustments shall be
made  for  dividends,   distributions  or  other  rights  (whether  ordinary  or
extraordinary,  and whether in cash,  Common  Stock,  other  securities or other
property)  for  which  the  record  date is prior to the date  such  shares  are
delivered.

2.3   GRANT OF OPTIONS.

The Committee may grant Options to purchase shares of Common Stock from Calypte,
in such amounts and subject to such terms and  conditions  as the  Committee may
determine.  The price of an Option  under this Plan shall be  determined  in the
sole discretion of the Committee; provided, however, if the Committee designates
an Option as an Incentive  Stock Option,  then such Option shall be granted only
to an employee of the  Company,  shall have a per share price not less than 100%
of the Fair Market  Value of a share of Common Stock on the date of grant of the
Option,  and, if granted to a person who owns  capital  stock  (including  stock
treated as owned under Section 424(d) of the Code)  possessing  more than 10% of
the total  combined  voting power of all classes of capital stock of the Company
(a "10%  Owner"),  have a per share  price not less than 110% of the Fair Market
Value of a share of Common Stock on the date of grant, and shall be for a period
of not more than 10 years  (five  years if the  Grantee is a 10% Owner) from the
date of grant.  Notwithstanding designation as an Incentive Stock Option, if the
shares of Common Stock subject to a grantee's  Incentive Stock Options  (granted
under all plans of the  Company),  which become  exercisable  for the first time
during any calendar  year,  have a Fair Market Value in excess of $100,000,  the
Options accounting for the excess will be treated as Nonqualified Stock Options.
Incentive  Stock  Options  will be taken into account in the order in which they
were  granted,  and the Fair Market  Value of the shares of Common Stock will be
determined as of the date of grant.

                                       39



1.1   STOCK APPRECIATION RIGHTS.

      The Committee may grant Stock Appreciation  Rights in conjunction with all
or part of an Option granted under the Plan. In the case of a Nonqualified Stock
Option,  such rights may be granted either at or after the date of grant of such
Option.  In the case of an Incentive  Stock  Option,  such rights may be granted
only at the date of grant  of such  Option.  A Stock  Appreciation  Right  shall
terminate and no longer be exercisable  upon the  termination or exercise of the
related Option. In either case, the terms and conditions of a Stock Appreciation
Right shall be set forth in the Award  Agreement  for the  related  Option or an
amendment thereto.  Stock Appreciation  Rights shall be exercisable only at such
time or times and to the extent  that the  Options to which  they  relate.  Upon
exercise of a Stock  Appreciation  Right, a grantee shall be entitled to receive
an amount equal to the product of (a) the excess of the Fair Market Value of one
share of Common Stock over the exercise price per share specified in the related
Option times (b) the number of shares in respect of which the Stock Appreciation
Right shall have been exercised,  in cash,  shares of Common Stock or both, with
the Committee having the right to determine the form of payment.

2.5   EXERCISE OF OPTIONS AND STOCK APPRECIATION RIGHTS.

      2.5.1 Any  acceptance  by the Committee of a grantee's  written  notice of
exercise of an Option  shall be  conditioned  upon  payment for the shares being
purchased.  Such  payment  may be made in cash or by such  other  method  as the
Committee may from time to time prescribe.

      2.5.2 After receiving payment from the grantee of the full Option exercise
price,  or after  receiving  notice from the grantee of the  exercise of a stock
appreciation  right for which payment will be made by Calypte partly or entirely
in shares of Common Stock,  Calypte shall, subject to the provisions of the Plan
or any Award Agreement, deliver the shares of Common Stock.

2.6   GRANT OF DIVIDEND EQUIVALENT RIGHTS.

      The Committee may include in the Award Agreement with respect to any Award
a dividend  equivalent  right  entitling the grantee to receive amounts equal to
all or any portion of the  dividends  that would be paid on the shares of Common
Stock covered by such Award if such shares had been  delivered  pursuant to such
Award. The grantee of a dividend equivalent right will have only the rights of a
general  unsecured  creditor of Calypte until payment of such amounts is made as
specified in the applicable  Award  Agreement.  In the event such a provision is
included in an Award  Agreement,  the  Committee  shall  determine  whether such
payments  shall be made in cash,  in shares of Common Stock or in another  form,
whether they shall be  conditioned  upon the exercise of the Award to which they
relate,  the time or times at which they shall be made, and such other terms and
conditions as the Committee shall deem appropriate.

2.7   GRANT OF RESTRICTED STOCK.

      The  Committee  may  grant or offer for sale  restricted  shares of Common
Stock in such amounts and subject to such terms and  conditions as the Committee
shall  determine,   including   restrictions   based  upon  the  achievement  of
Performance Goals,  time-based  restrictions on vesting following the attainment
of the Performance  Goals;  provided,  that such  restrictions  may lapse, if so
determined  by the  Committee,  in the  event of the  Grantee's  Termination  of
Employment due to death,  Disability or Termination of Employment by the Company
without  Cause.  Upon the delivery of  restricted  shares of Common  Stock,  the
grantee  shall have the rights of a shareholder  with respect to the  restricted
stock,  subject to any  restrictions and conditions as the Committee may include
in the applicable Award Agreement.  In the event that a Certificate is issued in
respect of restricted shares of Common Stock, such Certificate may be registered
in the name of the grantee but shall be held by Calypte or its designated  agent
until the time the restrictions lapse.

2.8   GRANT OF RESTRICTED STOCK UNITS.

      The Committee  may grant Awards of restricted  stock units in such amounts
and subject to such terms and  conditions as the Committee  shall  determine.  A
grantee  of a  restricted  stock  unit will  have  only the  rights of a general
unsecured  creditor of Calypte until  delivery of shares of Common Stock or cash
is made as specified in the applicable  Award  Agreement.  On the delivery date,
the grantee of each restricted stock unit not previously forfeited shall receive
one share of Common Stock or cash equal in value to a share of Common Stock or a
combination thereof, as specified by the Committee.


                                       40



2.9   GRANT OF OTHER STOCK-BASED AWARDS.

      The  Committee  may grant other types of  equity-based  or  equity-related
Awards  (including the grant or offer for sale of unrestricted  shares of Common
Stock) in such amounts and subject to such terms and conditions as the Committee
shall determine.  Such Awards may entail the transfer of actual shares of Common
Stock to Plan participants,  or payment in cash or otherwise of amounts based on
the value of shares of Common Stock.

2.10  GRANT OF INCENTIVE AWARDS.

      The  Committee may grant  Incentive  Awards in such amounts and subject to
the achievement of Performance Goals during Performance  Periods and other terms
and  conditions  as the Committee  shall  determine.  Incentive  Awards shall be
granted and  administered  to comply with the  requirements of Section 162(m) of
the Code. After the applicable  Performance  Period has ended, the grantee shall
be  entitled to payment  based on the level of  achievement  of the  Performance
Goals set by the Committee.  The Committee  shall certify the achievement of the
Performance  Goals in writing  before the  Incentive  Award is  settled.  At the
discretion of the Committee,  the settlement of Incentive Awards may be in cash,
shares of Common  Stock,  or in some  combination  thereof,  as set forth in the
Award  Agreement.  If a grantee  is  promoted  or demoted  during a  Performance
Period,  then,  to the  extent the  Committee  determines  that the  Award,  the
Performance  Goals or the  Performance  Period  are no longer  appropriate,  the
Committee may adjust,  change,  eliminate or cancel the Award,  the  Performance
Goals or the applicable  Performance Period, as it deems appropriate in order to
make them appropriate and comparable to the initial Award, the Performance Goals
or the Performance Period.

2.11  TAX OFFSET BONUSES.

      At the time an  Award is made  hereunder  or at any time  thereafter,  the
Committee may grant to the grantee  receiving  such Award the right to receive a
cash payment in an amount specified by the Committee, to be paid at such time or
times (if ever) as the Award results in compensation income to the grantee,  for
the  purpose  of  assisting  the  grantee  to pay the  resulting  taxes,  all as
determined  by the  Committee,  and on such other  terms and  conditions  as the
Committee shall determine.


                                   ARTICLE III

                                  MISCELLANEOUS

3.1   AMENDMENT OF THE PLAN.

      3.1.1 The Board may from time to time alter, suspend, discontinue, revise,
amend  or  terminate  the  Plan in any  respect  whatsoever,  provided,  that no
termination,  amendment,  or modification of the Plan shall adversely  affect in
any  material  way any Award  previously  granted  under the Plan,  without  the
written consent of the grantee of such Award,  except as otherwise  specifically
permitted in the Plan or such Award Agreement.

      3.1.2 Unless otherwise  determined by the Board,  shareholder  approval of
any suspension, discontinuance,  revision or amendment shall be obtained only to
the extent  necessary to comply with any  applicable  law, rule or regulation or
stock exchange requirement.

3.2   TAX WITHHOLDING.

      3.2.1 As a  condition  to the  delivery  of any  shares  of  Common  Stock
pursuant to any Award or the lifting or lapse of  restrictions  on any Award, or
in  connection  with any other  event  that  gives  rise to a  federal  or other
governmental  tax  withholding  obligation  on the part of Calypte or any of its
subsidiaries or affiliates relating to an Award (including,  without limitation,
FICA tax),  (a)  Calypte  may deduct or  withhold  (or cause to be  deducted  or
withheld) from any payment or  distribution to a grantee whether or not pursuant
to the Plan or (b) the  Committee  shall be entitled to require that the grantee
remit cash to Calypte or any of its subsidiaries or affiliates  (through payroll
deduction or otherwise),  in each case in an amount sufficient in the opinion of
Calypte to satisfy such withholding obligation.


                                       41



      3.2.2 If the event giving rise to the  withholding  obligation  involves a
transfer of shares of Common Stock,  then, unless the applicable Award Agreement
provides otherwise, at the discretion of the Committee,  the grantee may satisfy
the  withholding  obligation  described  under Section 3.2.1 by electing to have
Calypte withhold shares of Common Stock (which withholding will be at a rate not
in excess of the statutory minimum rate) or by tendering previously owned shares
of Common Stock,  in each case having a Fair Market Value equal to the amount of
tax to be withheld (or by any other  mechanism as may be required or appropriate
to conform with local tax and other rules). For this purpose,  Fair Market Value
shall be  determined as of the date on which the amount of tax to be withheld is
determined  (and Calypte may cause any fractional  share amount to be settled in
cash).

3.3   REQUIRED CONSENTS AND LEGENDS.

      3.3.1 If the Committee  shall at any time  determine  that any consent (as
hereinafter  defined)  is  necessary  or  desirable  as a  condition  of,  or in
connection  with,  the  granting of any Award,  the delivery of shares of Common
Stock or the delivery of any cash,  securities or other property under the Plan,
or the taking of any other action thereunder (each such action being hereinafter
referred to as a "plan  action"),  then such plan action shall not be taken,  in
whole or in part,  unless and until such  consent  shall have been  effected  or
obtained to the full  satisfaction  of the  Committee.  The Committee may direct
that any Certificate evidencing shares delivered pursuant to the Plan shall bear
a legend setting forth such restrictions on transferability as the Committee may
determine  to be necessary or  desirable,  and may advise the transfer  agent to
place a stop order against any legended shares.

      3.3.2 The term  "consent"  as used herein with  respect to any plan action
includes (a) any and all listings,  registrations or  qualifications  in respect
thereof upon any securities exchange or under any federal,  state, or local law,
or law, rule or regulation of a jurisdiction  outside the United States, (b) any
and all written  agreements and  representations  by the grantee with respect to
the  disposition  of  shares,  or with  respect to any other  matter,  which the
Committee  may deem  necessary or desirable to comply with the terms of any such
listing,  registration  or  qualification  or to  obtain an  exemption  from the
requirement  that any such listing,  qualification  or registration be made, (c)
any and all other consents, clearances and approvals in respect of a plan action
by  any  governmental  or  other  regulatory  body  or  any  stock  exchange  or
self-regulatory  agency and (d) any and all consents or authorizations  required
to comply  with,  or  required  to be obtained  under,  applicable  local law or
otherwise  required by the Committee.  Nothing  herein shall require  Calypte to
list, register or qualify the shares of Common Stock on any securities exchange.

3.4   NONASSIGNABILITY.

      Except to the extent otherwise  expressly provided in the applicable Award
Agreement,  no Award (or any rights and obligations  thereunder)  granted to any
person under the Plan may be sold, exchanged,  transferred,  assigned,  pledged,
hypothecated  or  otherwise  disposed  of  (including  through  the  use  of any
cash-settled  instrument) (each such action being hereinafter  referred to as an
"assignment"),  whether  voluntarily or involuntarily,  other than by will or by
the laws of  descent  and  distribution,  and all such  Awards  (and any  rights
thereunder)  shall be  exercisable  during the life of the  grantee  only by the
grantee or the grantee's legal  representative.  Notwithstanding the immediately
preceding  sentence,  the Committee may permit,  under such terms and conditions
that it deems  appropriate  in its sole  discretion,  a grantee to transfer  any
Award to any person or entity that the Committee so  determines.  Any assignment
in violation  of the  provisions  of this Section 3.4 shall be void.  All of the
terms and conditions of this Plan and the Award Agreements shall be binding upon
any such permitted successors and assigns.

3.5   REQUIREMENT OF CONSENT AND NOTIFICATION OF ELECTION UNDER SECTION 83(B) OF
      THE CODE OR SIMILAR PROVISION.

      No election under Section 83(b) of the Code (to include in gross income in
the year of transfer the amounts  specified  in Code  Section  83(b)) or under a
similar provision of the law of a jurisdiction  outside the United States may be
made unless expressly permitted by the terms of the Award Agreement or by action
of the Committee in writing prior to the making of such  election.  If a grantee
of an Award,  in connection with the acquisition of shares of Common Stock under
the Plan or  otherwise,  is  expressly  permitted  under  the terms of the Award
Agreement or by such Committee  action to make any such election and the grantee
makes the  election,  the grantee  shall notify the  Committee of such  election
within ten (10) days of filing notice of the election with the Internal  Revenue
Service  or  other  governmental  authority,  in  addition  to  any  filing  and
notification required pursuant to regulations issued under Code Section 83(b) or
other applicable provision.


                                       42


3.6   REQUIREMENT OF NOTIFICATION UPON  DISQUALIFYING  DISPOSITION UNDER SECTION
      421(B) OF THE CODE.

      If any  grantee  shall  make any  disposition  of shares  of Common  Stock
delivered  pursuant  to the  exercise of an  Incentive  Stock  Option  under the
circumstances  described  in  Section  421(b) of the Code  (relating  to certain
disqualifying   dispositions),   such  grantee  shall  notify  Calypte  of  such
disposition within 10 days thereof.

3.7   CHANGE IN CONTROL.

      3.7.1 The  Committee  may provide in any Award  Agreement  for  provisions
relating  to a "change in  control"  of Calypte  (as such term is defined by the
Committee  in any such Award  Agreement),  including,  without  limitation,  the
acceleration or extension of the exercisability of, or the lapse of restrictions
or deemed satisfaction of goals with respect to, any outstanding Awards.

      3.7.2 Unless otherwise provided in the applicable Award Agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of  Calypte  with or into any  other  entity  ("successor
entity") or any  transaction in which another  person or entity  acquires all of
the issued and outstanding Common Stock of Calypte,  or all or substantially all
of the assets of  Calypte,  outstanding  Awards may be assumed or an  equivalent
Award may be substituted  by such successor  entity or a parent or subsidiary of
such successor entity.

3.8   RIGHT OF DISCHARGE RESERVED.

      Nothing  in the  Plan or in any  Award  Agreement  shall  confer  upon any
grantee  the right to  continued  Employment  by the Company or affect any right
which the Company may have to terminate such Employment.

3.9   NATURE OF PAYMENTS.

      3.9.1 Any and all grants of Awards and  deliveries of Common Stock,  cash,
securities  or other  property  under  the Plan  shall  be in  consideration  of
services  performed  or to be performed  for the Company by the grantee.  Awards
under the Plan may, in the discretion of the Committee,  be made in substitution
in  whole or in part for cash or  other  compensation  otherwise  payable  to an
Employee.

      3.9.2  All  such  grants  and  deliveries   shall   constitute  a  special
discretionary  incentive  payment to the grantee and shall not be required to be
taken into  account in  computing  the amount of salary or  compensation  of the
grantee for the purpose of  determining  any  contributions  to or any  benefits
under any pension, retirement,  profit-sharing, bonus, life insurance, severance
or other  benefit plan of the Company or under any  agreement  with the grantee,
unless the Company specifically provides otherwise.

3.10  NON-UNIFORM DETERMINATIONS.

      The Committee's  determinations  under the Plan and Award  Agreements need
not be uniform and may be made by it selectively  among persons who receive,  or
are eligible to receive,  Awards under the Plan (whether or not such persons are
similarly  situated).  Without  limiting the  generality of the  foregoing,  the
Committee  shall be  entitled,  among  other  things,  to make  non-uniform  and
selective  determinations under Award Agreements,  and to enter into non-uniform
and selective Award Agreements, as to (a) the persons to receive Awards, (b) the
terms and  provisions of Awards and (c) whether a grantee's  Employment has been
terminated for purposes of the Plan.

3.11  OTHER PAYMENTS OR AWARDS.

      Nothing  contained  in the  Plan  shall be  deemed  in any way to limit or
restrict  Calypte from making any award or payment to any person under any other
plan, arrangement or understanding, whether now existing or hereafter in effect.


                                       43



3.12  PLAN HEADINGS.

      The headings in this Plan are for the purpose of convenience  only and are
not intended to define or limit the construction of the provisions hereof.

3.13  DATE OF ADOPTION AND TERM OF PLAN.

      The Plan was adopted by the Board on February 24, 2004 and made  effective
as of  the  date  of  approval  by the  Company's  stockholders.  Unless  sooner
terminated  by the Board,  the Plan shall  terminate on the day before the tenth
anniversary  of the effective  date of the Plan. The Board reserves the right to
terminate the Plan at any time;  provided,  however,  that all Awards made under
the Plan prior to its termination  shall remain in effect until such Awards have
been satisfied or terminated in accordance  with the terms and provisions of the
Plan and the applicable Award Agreements.

3.14  GOVERNING LAW.

      ALL RIGHTS AND  OBLIGATIONS  UNDER THE PLAN AND EACH AWARD AGREEMENT SHALL
BE  GOVERNED  BY AND  CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  STATE OF
DELAWARE, WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS.

3.15  SEVERABILITY; ENTIRE AGREEMENT.

      If any of the  provisions  of this Plan or any Award  Agreement is finally
held to be invalid, illegal or unenforceable (whether in whole or in part), such
provision  shall be deemed  modified to the extent,  but only to the extent,  of
such invalidity,  illegality or  unenforceability  and the remaining  provisions
shall not be  affected  thereby;  provided,  that if any of such  provisions  is
finally held to be invalid,  illegal,  or  unenforceable  because it exceeds the
maximum  scope  determined  to be  acceptable  to permit  such  provision  to be
enforceable, such provision shall be deemed to be modified to the minimum extent
necessary  to  modify  such  scope in order to make such  provision  enforceable
hereunder. The Plan and any Award Agreements contain the entire agreement of the
parties  with  respect to the subject  matter  thereof and  supersede  all prior
agreements, promises, covenants, arrangements,  communications,  representations
and warranties between them, whether written or oral with respect to the subject
matter thereof.

3.16  WAIVER OF CLAIMS.

      Each  grantee  of an  Award  recognizes  and  agrees  that  prior to being
selected  by the  Committee  to  receive  an Award he or she has no right to any
benefits  hereunder.  Accordingly,  in consideration of the grantee's receipt of
any Award hereunder,  he or she expressly waives any right to contest the amount
of any Award, the terms of any Award  Agreement,  any  determination,  action or
omission  hereunder or under any Award Agreement by the Committee,  Calypte,  or
the Board,  or any amendment to the Plan or any Award  Agreement  (other than an
amendment  to this Plan or an Award  Agreement  to which his or her  consent  is
expressly required by the express terms of an Award Agreement).

3.17  NO THIRD PARTY BENEFICIARIES.

      Except  as  expressly  provided  therein,  neither  the Plan nor any Award
Agreement  shall  confer on any person other than the Company and the grantee of
any Award any rights or remedies thereunder.

3.18  SUCCESSORS AND ASSIGNS OF CALYPTE.

      The terms of this Plan shall be binding  upon and inure to the  benefit of
Calypte and its successors and assigns.



                                       44



                         CALYPTE BIOMEDICAL CORPORATION
                             1265 HARBOR BAY PARKWAY
                            ALAMEDA, CALIFORNIA 94502

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned  hereby appoints  ANTHONY J. CATALDO and J. RICHARD GEORGE,  and
each of them,  with full power of  substitution,  as the proxy or proxies of the
undersigned to vote all shares of Common Stock of Calypte Biomedical Corporation
which the  undersigned is entitled to vote at the annual meeting of stockholders
of Calypte Biomedical  Corporation to be held at Signature Center,  5000 Hopyard
Road, 4th Floor,  Pleasanton,  California  94588 on June 22, 2004, at 10:00 a.m.
local time, and at any  adjournments or postponements  thereof,  with all powers
that the undersigned would have if personally present thereat:

                            (CONTINUED ON OTHER SIDE)


                          /*\ FOLD AND DETACH HERE /*\

- --------------------------------------------------------------------------------

PLEASE MARK                |X|
YOUR VOTES
AS THIS


This proxy when properly executed will be voted in the manner directed herein by
the undersigned stockholder. If no direction is made, this proxy will be voted
FOR Proposals 1, 2 and 3.



                                                                                                                  WITHHOLD
                                                                                                                 AUTHORITY TO
                                                                                       FOR ALL NOMINEES          VOTE FOR ALL
                                                                                    EXCEPT AS MARKED TO THE        NOMINEES
                                                                                        CONTRARY BELOW)          LISTED BELOW
                                                                                                           
 1.   Election of Directors                                                                   |_|                    |_|
      Anthony J. Cataldo; John J. DiPietro; Paul E. Freiman; Julius R. Krevans,
      M.D.; Zafar I. Randawa, Ph.D.; and Maxim A. Soulimov.
      (The Board of Directors recommends a vote FOR.)

      This proxy will be voted in the election of directors in the manner
      described in the proxy statement for the 2004 annual meeting of
      stockholders. (INSTRUCTION: To withhold authority to vote for one or more
      individual nominees, write such name or names in the space provided to the
      right.)

2.    Proposal to adopt the Company's 2004 Incentive Plan and to authorize                FOR          AGAINST        ABSTAIN
      30,000,000 shares of Common Stock to be reserved for issuance thereunder.           |_|            |_|             |_|
      (The Board of Directors recommends a vote FOR.)

3.    Proposal to ratify the appointment of Odenberg Ullakko Muranishi & Co. LLP          FOR          AGAINST        ABSTAIN
       as the Company's independent accountants for the 2004 fiscal year.                 |_|            |_|             |_|
      (The Board of Directors recommends a vote FOR.)


In their discretion, the proxies are authorized to vote upon such other business
as may properly come before the meeting and at any  adjournment or  postponement
thereof.


      PLEASE  MARK,  SIGN,  DATE AND RETURN THE PROXY  CARD  PROMPTLY  USING THE
ENCLOSED  ENVELOPE.  Signature of  Stockholder____________________  Signature if
held jointly  ___________________  Dated: ________,  2004 Please sign exactly as
name appears  above.  When shares are held by joint  tenants,  both should sign.
When signing as attorney, executor,  administrator,  trustee or guardian, please
give full title as such. If a corporation, please sign in full corporate name by
President or other authorized person.


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