Exhibit 32.1

                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350
                    AS ADOPTED PURSUANT TO SECTION 906 OF THE
                           SARBANES-OXLEY ACT OF 2002

      In  connection  with  the  Quarterly  Report  on Form  10-Q  of  Discovery
Laboratories, Inc. (the "Company"), for the period ended June 30, 2004, as filed
with the  Securities  and Exchange  Commission  (the  "Commission")  on the date
hereof (the "Report"), each of the undersigned, in his capacity as an officer of
the Company, certifies,  pursuant to 18 U.S.C. Section 1350, as adopted pursuant
to Section 906 of the Sarbanes-Oxley Act of 2002, that:

      1.    the Report fully complies with the  requirements of Section 13(a) or
            15(d) of the Securities Exchange Act of 1934, as amended; and

      2.    the  information  contained in the Report  fairly  presents,  in all
            material respects, the financial condition and results of operations
            of the Company.

      A signed original of this written statement required by Section 906 of the
Sarbanes-Oxley Act of 2002 has been provided to the Company and will be retained
by the Company and furnished to the Commission or its staff upon request.

Date:  August  9, 2004

Name:  /s/ Robert J. Capetola
       --------------------------
Name:  Robert J. Capetola, Ph.D.
Title: President, and
       Chief Executive Officer

Name:  /s/ John G. Cooper
       --------------------------
Name:  John G. Cooper
Title: Executive Vice President, and
       Chief Financial Officer



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