EXHIBIT 32.1


CERTIFICATE OF THE PRINCIPAL EXECUTIVE OFFICER
OF DIOMED HOLDINGS, INC. (REGISTRANT)
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         I, James A. Wylie,  Jr.,  Chief  Executive  Officer of the  Registrant,
certify to the best of my  knowledge  and  belief  pursuant  to  Section  906 of
Sarbanes-Oxley Act of 2002 (18 U.S.C. Section 1350) that:

          (1)     The Quarterly  Report on Form 10-QSB for the period ended June
                  30, 2004,  which this  statement  accompanies,  fully complies
                  with  the  requirements  of  section  13(a)  or  15(d)  of the
                  Securities Exchange Act of 1934; and

          (2)     The  information  contained  in the  Quarterly  Report on Form
                  10-QSB  fairly  presents,   in  all  material  respects,   the
                  financial   condition   and  result  of   operations   of  the
                  Registrant.


Date:  August 12, 2004                             /s/ JAMES A. WYLIE, JR.
                                                   ---------------------------
                                                   James A. Wylie, Jr.
                                                   Chief Executive Officer
                                                   (Principal Executive Officer)