Exhibit 5.1

                    [Dickstein Shapiro Morin & Oshinsky LLP]

                                 August 26, 2004


Board of Directors
Discovery Laboratories, Inc.
350 South Main Street, Suite 307
Doylestown, PA 18901

                         Discovery Laboratories, Inc.--
                       Registration Statement on Form S-3

Ladies and Gentlemen:

                  We have acted as counsel for Discovery  Laboratories,  Inc., a
Delaware corporation (the "Company"),  in connection with the preparation of the
registration  statement on Form S-3, and any amendments or  supplements  thereto
(the  "Registration  Statement"),  as filed  with the  Securities  and  Exchange
Commission (the  "Commission")  under the Securities Act of 1933 (the "Act"), on
August 26, 2004, for the registration  under the Act of up to 15,375,000  shares
of the Company's  common stock, par value $0.001 per share (the "Common Stock"),
of which there are (i)  15,000,000  shares of Common Stock (the  "Shares")to  be
issued and sold at the discretion of the Company to Kingsbridge  Capital Limited
under a Common Stock Purchase Agreement dated as of July 7, 2004 (the " Purchase
Agreement"),  and (ii)  375,000  shares of Common Stock (the  "Warrant  Shares")
which are issuable upon the exercise of certain  warrants  issued by the Company
(the "Warrants"). The Shares and the Warrant Shares are to be offered for resale
on a delayed or  continuous  basis  pursuant to Rule 415  promulgated  under the
Securities  Act  by  the  selling  stockholders  of  the  Company  named  in the
Registration Statement.

                  In rendering  this opinion,  we have relied upon,  among other
things,  our  examination of certain records of the Company,  including  without
limitation, the Company's Restated Certificate of Incorporation, as amended, the
Company's  Bylaws  and  resolutions  of the  Board of  Directors.  We have  also
examined  certificates of the Company's  officers and of public  officials,  and
have reviewed such  questions of law and made such other  inquiries,  as we have
deemed necessary or appropriate for the purpose of rendering this opinion. As to
various  questions of fact  material to this  opinion,  we have also relied upon
representations  and  warranties of the Company and upon such  certificates  and
other  instruments of officers of the Company and public officials  furnished to
us  by  the  Company,  in  each  case  without   independent   investigation  or
verification.

                  In  addition,   without  any  independent   investigation   or
verification,  we have assumed (i) the genuineness of all  signatures,  (ii) the
authenticity  of all documents  submitted to us as originals and the  conformity
with the original  documents  of all  documents  submitted  to us as  certified,
conformed or photostatic copies,  (iii) the authority of all persons signing any
document other than the officers of the Company,  where  applicable,  signing in
their  capacity as such,  (iv) the  enforceability  of all the documents we have
reviewed in accordance with their  respective  terms against the parties thereto
and  (v) the  truth  and  accuracy  of all  matters  of fact  set  forth  in all
certificates and other instruments furnished to us.




                  Based on and subject to the  assumptions,  qualifications  and
limitations set forth herein, we are of the opinion that:

                  1. The  Shares  have been  duly  authorized  by all  necessary
corporate  action  of the  Company,  and upon  issuance,  delivery  and  payment
therefor in the manner contemplated by the Purchase  Agreement,  will be validly
issued, fully paid and nonassessable.

                  2. The Warrant  Shares have been duly  authorized for issuance
pursuant to the Warrant,  and when issued and delivered in the manner  described
in the Warrant against full payment of the consideration set forth therein, will
be validly issued, fully paid and nonassessable.

                  We do not  express any opinion as to the laws of any states or
jurisdictions  other  than  the laws of the  State  of New York and the  General
Corporation  Law of the State of  Delaware.  No opinion is  expressed  as to the
effect that the law of any other  jurisdiction  may have upon the subject matter
of the opinion  expressed  herein under conflicts of law  principles,  rules and
regulations or otherwise.

                  This  opinion  is  limited to the  specific  issues  addressed
herein,  and no opinion may be inferred or implied beyond that expressly  stated
herein.  We assume no obligation to revise or supplement this opinion should the
present laws of the State of New York or the state  Constitution  or the General
Corporation  Law of the State of  Delaware  be  changed by  legislative  action,
judicial decision or otherwise.

                  We  hereby  consent  to the  filing of this  opinion  with the
Commission as Exhibit 5.1 to the Registration  Statement and the reference to us
under the heading "Legal  Matters" in the  prospectus  included in Part I of the
Registration  Statement.  In giving  this  consent,  we do not admit that we are
within the  category  of persons  whose  consent is required by Section 7 of the
Securities  Act or the  rules  and  regulations  promulgated  thereunder  by the
Commission.

                  This opinion is furnished to you in connection with the filing
of the  Registration  Statement  and is not to be used,  circulated,  quoted  or
otherwise relied upon for any other purposes.

                  We wish to call  your  attention  to the  fact  that  the fair
market value of all  securities  of the Company that are  beneficially  owned by
attorneys of this Firm exceeds $50,000.

                                    Very truly yours,

                                    /s/ Dickstein Shapiro Morin & Oshinsky LLP