SCHEDULE 14A INFORMATION

                  PROXY STATEMENT PURSUANT TO SECTION 14(A) OF
                       THE SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant    [X]

Filed by a Party other than the Registrant    [_]

Check the appropriate box:

[X]   Preliminary Proxy Statement             [_]  Confidential, for Use of the
                                                   Commission Only (as permitted
                                                   by Rule 14a-6(e)(2))

[_]   Definitive Proxy Statement

[_]   Definitive Additional Materials

[_]   Soliciting Material Pursuant to ss.240.14a-12


                         CALYPTE BIOMEDICAL CORPORATION
                (NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

       (NAME OF PERSON(S) FILING PROXY STATEMENT IF OTHER THAN REGISTRANT)

Payment of Filing Fee (Check the appropriate box):

[X]   No fee required

[_]   Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      (1)   Title of each class of securities to which transaction applies:

      (2)   Aggregate number of securities to which transaction applies:

      (3)   Per unit price or other  underlying  value of  transaction  computed
            pursuant  to  Exchange  Act Rule 0-11 (set forth the amount on which
            the filing fee is calculated and state how it was determined):

      (4)   Proposed maximum aggregate value of transaction:

      (5)   Total fee paid:

[_]   Fee paid previously with preliminary materials.

[_]   Check box if any part of the fee is offset as  provided  by  Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.

      (1)   Amount Previously Paid:

      (2)   Form, Schedule or Registration Statement No.:

      (3)   Filing Party:

      (4)   Date Filed:

================================================================================


                               [GRAPHIC OMITTED]
                               CALYPTE BIOMEDICAL
                          5000 Hopyard Road, Suite 480
                          Pleasanton, California 94588

November __, 2004

Dear Stockholder:

      You  are  cordially  invited  to  attend  a  Special  Meeting  of  Calypte
Biomedical Corporation's Stockholders on Tuesday, December 14, 2004. The meeting
will begin  promptly at 10:00 a.m.  local time,  at the  Company's  headquarters
offices  located at 5000 Hopyard  Road,  Suite 480,  Pleasanton,  CA 94588.  The
telephone number at that location is (925)730-7200.

      The official Notice of Special Meeting of  Stockholders,  Proxy Statement,
and form of proxy are  included  with this  letter.  The Company has  previously
furnished its 2003 Annual Report to Stockholders in conjunction  with the Annual
Meeting of Stockholders held earlier this year. The matters listed in the Notice
of  Special  Meeting  of  Stockholders  are  described  in  detail  in the Proxy
Statement.

      Your vote is  important.  Whether  or not you plan to attend  the  special
meeting,  I urge you to  complete,  sign and date the  enclosed  proxy  card and
return it in the  accompanying  envelope or vote by telephone or on-line as soon
as possible so that your stock may be represented at the meeting.

                                           Sincerely,


                                           /s/  J. Richard George
                                           -------------------------------------
                                           J. Richard George
                                           President and Chief Executive Officer


                                       2


                               CALYPTE BIOMEDICAL
                          5000 Hopyard Road, Suite 480
                          Pleasanton, California 94588

                    NOTICE OF SPECIAL MEETING OF STOCKHOLDERS
                         TO BE HELD ON DECEMBER 14, 2004

November __, 2004

      A Special Meeting of Stockholders of Calypte  Biomedical  Corporation (the
"Company")  will be held at the Company's  headquarters  offices located at 5000
Hopyard Road, Suite 480, Pleasanton, California, 94588, on Tuesday, December 14,
2004, at 10:00 a.m. local time, for the following purposes:

      1.    To  authorize  the  Company's  Board of  Directors  to enter  into a
            financing  transaction  to raise up to $16.5 million by the issuance
            of Common  Stock or  equivalents  and/or the issuance of warrants to
            purchase  shares of Common Stock within 90 days from the date of the
            Special  Meeting on terms and conditions that may result in dilution
            to stockholders  and may trigger certain  anti-dilution  protections
            provided to certain existing  stockholders.  Stockholder approval of
            the within  proposal  is required  for the  Company to maintain  its
            listing on the American  Stock  Exchange in the event that it issues
            shares of Common  Stock or warrants  that results in the issuance in
            excess of 20% of its currently  issued and outstanding  Common Stock
            or if the anti-dilution  provisions provided to certain stockholders
            are triggered.


      2.    To  transact  such other  business as may  properly  come before the
            Special Meeting or any adjournment thereof.

      Stockholders  of record on October  22,  2004 will be  eligible to vote at
this meeting.  Only stockholders of record at the close of business on that date
will be  entitled  to  notice  of and to vote at the  meeting.  To  ensure  your
representation at the meeting,  you are urged to mark, sign, date and return the
enclosed  proxy as promptly as possible in the  envelope  provided or to vote by
telephone or via the internet. If you attend the meeting, you may vote in person
even if you return a proxy.

                                           By order of the Board of Directors,


                                           /s/ Jerrold Dotson
                                           -------------------------------------
                                           Jerrold Dotson
                                           Corporate Secretary

                             YOUR VOTE IS IMPORTANT

 WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING, PLEASE COMPLETE AND RETURN THE
PROXY CARD IN THE ENVELOPE PROVIDED, WHICH REQUIRES NO POSTAGE IF MAILED IN THE
                                 UNITED STATES.


                                       3


                               CALYPTE BIOMEDICAL
                          5000 Hopyard Road, Suite 480
                          Pleasanton, California 94588

                                PROXY STATEMENT

      This Proxy Statement is furnished in connection  with the  solicitation of
proxies on behalf of the Board of Directors (the "Board") of Calypte  Biomedical
Corporation ("Calypte" or the "Company") for the Special Meeting of Stockholders
(the "Special  Meeting"),  and any postponements or adjournments  thereof, to be
held at the Company's  headquarters  offices located at 5000 Hopyard Road, Suite
480,  Pleasanton,  California 94588, on Tuesday December 14, 2004, at 10:00 a.m.
local  time.  The  telephone  number at that  address is (925)  730-7200.  Every
stockholder  shall  have the right to vote  whether  in person or by one or more
agents  authorized by a written proxy signed by the  stockholder  and filed with
the secretary of the Company.  The shares  represented by the proxies  received,
properly  dated  and  executed,  and not  revoked  will be voted at the  Special
Meeting. A proxy may be revoked at any time before it is exercised by delivering
to the Company a written notice of revocation or a duly executed proxy bearing a
later date or by attending the Special Meeting and voting in person.

                 INFORMATION CONCERNING SOLICITATION AND VOTING

      The close of  business  on October  22,  2004 has been fixed as the record
date (the "Record Date") for  determining  the holders of shares of common stock
of the Company,  par value $0.03 per share,  ("Common Stock") entitled to notice
of and to vote at the  Special  Meeting.  At October 22,  2004,  the Company had
169,321,669  shares of Common  Stock  outstanding  and  entitled  to vote at the
Special  Meeting.  The holders of a majority of voting power of the Common Stock
issued and outstanding and entitled to vote, present in person or represented by
proxy,  shall  constitute  a quorum at the Special  Meeting  except as otherwise
provided by statute.  Each holder of Common Stock on the Record Date is entitled
to one  vote for  each  share of  Common  Stock  held by such  stockholder,  and
stockholders  shall not be entitled to cumulate  their votes with respect to any
matter submitted to a vote of the stockholders.

      Shares represented by proxies that reflect abstentions or broker non-votes
will be counted as shares that are present and  entitled to vote for purposes of
determining  the  presence of a quorum.  The proposal to come before the Special
Meeting requires the approval of a majority of the shares of stock having voting
power  present.  Abstentions  with  respect to the  proposal  will have the same
effect as votes against the proposal. Broker non-votes, however, will be treated
as not voted for purposes of  determining  approval of the proposal and will not
be counted as votes for or against such proposal.

      The shares  represented by all valid proxies received will be voted in the
manner specified on the proxies.  Where specific choices are not indicated,  the
shares represented by all valid proxies received will be voted FOR authorization
to enter into a prospective financing transaction(s) of up to $16.5 million.

      Should any matter not  described  above be acted upon at the meeting,  the
persons named in the proxy form will vote in accordance with their judgment.

      The expense of printing and mailing proxy  materials  will be borne by the
Company.  In addition to the solicitation of proxies by mail,  solicitations may
be made by certain  directors,  officers  and other  employees of the Company by
personal interview,  telephone or facsimile.  No additional compensation will be
paid for such solicitation.  The Company may also, at its discretion, retain the
services  of a paid  solicitor  to solicit  proxies.  If the  Company  retains a
solicitor, it is anticipated that the cost will be approximately $5,500 and will
be paid by the Company.  The Company will request  brokers and nominees who hold
stock in their  names to furnish  proxy  material  to  beneficial  owners of the
shares  and will  reimburse  such  brokers  and  nominees  for their  reasonable
expenses incurred in forwarding solicitation material to such beneficial owners.


        PROSPECTIVE ISSUANCE OF SHARES OF COMMON STOCK OR EQUIVALENTS IN
      CONNECTION WITH A CAPITAL RAISING TRANSACTION OF UP TO $16.5 MILLION

                                   (PROPOSAL)

By unanimous vote of all Directors on September 22, 2004, the Company's Board of
Directors adopted, subject to stockholder approval, a resolution authorizing the
Company to enter into one or more financing transactions aggregating up to $16.5
million at such time and under such terms and  conditions  as the Board deems to
be in the best  interest of the Company to continue  its  business as more fully
described below.

DESCRIPTION OF PROPOSAL

To successfully  implement our business plans, we must obtain  sustainable  cash
flow and  profitability.  Our future  liquidity  and capital  requirements  will
depend on numerous factors,  including successful  completion of the development
and/or  commercialization of our new rapid tests,  acquisition and protection of
intellectual  property rights, costs of developing our new products,  ability to
transfer  technology,  set up manufacturing and obtain regulatory  approvals for
our new rapid tests, market acceptance of our products and competing products in
our current and anticipated markets,  actions by the FDA and other international
regulatory  bodies,  and the ability to raise additional  capital as required to
meet our cash  flow  needs.  Prior to  achieving  positive  cash  flow  from our
exsisting  business  with which we can sustain our current  operations,  we will
need to raise additional capital.

In the section entitled "Background of the Proposal" which follows, we summarize
the financing  arrangements  we have entered  between 2002 to present.  Although
management  believes that our current financial  position is adequate to sustain
our  operations  at  expected   levels  through  2004  in  the  absence  of  any
unanticipated  material  costs and expenses  that are not factored into our cash
flow  projections,  we expect that we will need to raise  additional  capital to
sustain  our  operations  and  achieve  our  business  milestones  in  2005  and
thereafter.  We may not,  however,  be able to obtain  additional  financing  on
acceptable terms, or at all. The terms of an additional  financing could involve
a change of control  and/or  trigger  anti-dilution  protection  rights that are
contained  in existing  financing  agreements.  We would or might be required to
consider strategic opportunities, such as a merger, consolidation, sale or other
comparable transactions, to sustain our operations. We do not currently have any
agreements in place with respect to any strategic opportunity,  and there can be
no assurance that any such  opportunities  will be available to us on acceptable
terms,  or at all. If additional  financing is not available when required or is
not  available on  acceptable  terms,  or if we are unable to arrange a suitable
strategic  opportunity,  we will be in significant financial jeopardy and may be
unable to continue our operations at current levels, or at all.

Although we currently have no agreements with respect to a prospective financing
transaction, we have historically raised money through the sale of shares of our
common  stock at a discount to the current  market  price,  through  convertible
debentures,  and through equity lines of credit. Such arrangements have included
the private sale of shares and  warrants to purchase  shares to investors on the
condition  that we  register  such  shares  for resale by the  investors  to the
public.   Some  of  our  prior   arrangements   contain  both  price  and  share
anti-dilution protection provisions.

These arrangements have most recently been in the form of private investments in
public equity ("PIPE")  transactions.  Approval of this proposal  authorizes the
Company to raise up to $16.5 million in a PIPE transaction for general corporate
purposes as we build  distribution and execute on our plan to generate  revenues
from our  rapid  HIV-1/2  products  under  development  and/or  currently  being
commercialized. The anticipated prospective terms are as follows:

      Common Stock or equivalents:
      a.    Discount to market not to exceed 25%;
      b.    Sold as a unit with warrant coverage, warrant priced at no less than
            25% discount to market;
      c.    Anti-dilution provisions having a threshold price not to exceed that
            of the Common Stock in the offering;
      d.    We  would  seek  to use our  best  efforts  to  file a  registration
            statement  within 30 days of closing,  with  standard  penalties for
            failure to file and register the securities in a timely manner; and
      e.    Expenses  are the normal  expenses of  registration  plus  financial
            consulting fees of up to 7% of the gross proceeds, plus fee warrants
            as  an  incentive  to  maximize  the  pricing  of  the   prospective
            transaction to the benefit of Calypte.


                                       2


Alternatively, we may elect to raise additional capital by issuing shares of our
Preferred  Stock under terms  similar to those  described  above.  The Preferred
Stock could be convertible into shares of our Common Stock and could be dividend
bearing, with dividends payable in kind, cash or Common Stock or warrants.

Should we raise $16.5  million in a  prospective  financing,  we would expect to
receive net proceeds of approximately $15.0 million, however we are uncertain as
to the terms of any PIPE we may undertake.

Under the terms of our existing Marr Credit Facility, through May 31, 2005, Marr
Technologies BV ("Marr"), our largest stockholder,  has the right to participate
in any  prospective  transaction  on the same terms and  conditions as the other
investors in a  prospective  financing.  The Marr Credit  Facility,  dated as of
November  13, 2003,  provides as follows  with  respect to Marr's  participation
rights:

      "Subsequent  Financings:  During  the term of this  Agreement,
      Issuer [Calypte] will notify Purchaser [Marr] of all offerings
      for equity financing which it may undertake. Equity financings
      shall, for the purposes of this Agreement,  be defined as cash
      received  by Issuer from the sale of  Issuer's  common  stock,
      $0.03 par value, or such other equity security as it may offer
      from  time to time,  for  cash,  specifically  excluding  cash
      received  from  the  exercise  of  currently   outstanding  or
      subsequently  granted options or warrants issued to employees,
      consultants,  or other parties for services or in lieu of cash
      for services or for intellectual property rights.

            i.    Issuer  will  grant  Purchaser  the right of first
                  refusal  to  participate  in any  such  subsequent
                  equity  financings  on  the  same  key  terms  and
                  conditions,   which   shall   include  the  dollar
                  investment  amount  or  number  of  shares  to  be
                  purchased,  pricing,  number of warrants and their
                  terms,  if any,  registration  rights and fees, as
                  applicable to the subject offer."

Under the terms of the respective Securities Purchase Agreements,  the investors
in our May 2004 PIPE, which also includes Marr, and our July 2004 PIPE also have
the  right to  participate  in a  prospective  financing  on the same  terms and
conditions  as  other  investors,  through  May  28,  2005  and  July  9,  2005,
respectively.  The Securities Purchase Agreements for both transactions  provide
as follows:

      "Right of Participation.  If at any time prior to the one year
      anniversary of the Closing Date, the Company proposes to issue
      any  equity   Common   Stock  or  Common   Stock   Equivalents
      (collectively, "NEW ISSUE SECURITIES"), the Company shall also
      offer the New Issue  Securities  to the Investors so that they
      can maintain their then ownership percentage."

A prospective  transaction  contemplated  by this Proposal  would qualify as New
Issue Securities under the terms of these agreements.  For a transaction at less
than $0.40 per share,  the right of  participation  operates in conjunction with
the  anti-dilution  protection  provisions,  as described  below,  to enable the
investor to maintain it's pre-transaction ownership percentage of Calypte.

Depending on the specific  pricing and format of a prospective  capital  raising
transaction,  the  transaction  may result in (1) the  issuance of an  aggregate
number of shares of our  Common  Stock  which  exceeds  20% of the number of our
currently  issued  and  outstanding   shares  of  Common  Stock,  and,  (2)  the
requirement that we issue additional shares and warrants, and re-price currently
outstanding  warrants,  in accordance with anti-dilution  protection  provisions
defined in the Securities  Purchase  Agreements and Warrants dated as of May 28,
2004 and July 9, 2004. The Securities Purchase Agreements provide  anti-dilution
protection as follows:

      "Additional Shares. If, prior to the first year anniversary of
      the  Closing  Date,  the  Company  issues any shares of Common
      Stock or the Company or any Subsidiary issues any Common Stock
      Equivalents  entitling any Person to acquire  shares of Common
      Stock at a price  per share  less  than  less  than  [sic] the
      Threshold Price [defined as $0.40 per share] (if the holder of
      the Common Stock or Common Stock Equivalent so issued shall at
      any time,  whether by operation of purchase price adjustments,
      reset provisions,  floating  conversion,  exercise or exchange
      prices or  otherwise,  or due to  warrants,  options or rights
      issued  in  connection  with such  issuance,  be  entitled  to
      receive  shares  of  Common  Stock  at a price  less  than the
      Threshold  Price,  such  issuance  shall  be  deemed  to  have
      occurred for less than the Threshold Price),


                                       3


      then, in connection with each such issuance of Common Stock or
      Common  Stock  Equivalents  for a purchase  price that is less
      than the Threshold Price, the Company shall  immediately issue
      additional shares of Common Stock (the "ADDITIONAL SHARES") to
      each Investor for no additional  consideration.  The number of
      Additional  Shares  issuable to each Investor will equal:  (a)
      the  Threshold  Price minus the lowest  price per share of the
      Common Stock or Common Stock Equivalents  offered or sold that
      trigger an  obligation  under this Section  divided by (b) the
      Threshold Price, multiplied by (c) the number of Shares issued
      to  such   Investor  at  the   Closing   pursuant  to  Section
      2.2(a)(i)."

A prospective  transaction as  contemplated  by this Proposal and priced at less
than $0.40 per share would require us to issue Additional Shares under the terms
of these agreements.

The warrants issued to the investors in our May 2004 PIPE and our July 2004 PIPE
contain the following provisions with respect to resetting of the exercise price
to provide anti-dilution protection:

      "Subsequent Equity Sales.

      If the Company or any subsidiary  thereof,  as applicable with
      respect to Common  Stock  Equivalents,  at any time while this
      Warrant is  outstanding,  shall  issue any  securities  of the
      Company or any Subsidiary  which entitle the holder thereof to
      acquire   Common   Stock  at  any  time,   including   without
      limitation,   any  debt,  preferred  stock,  rights,  options,
      warrants  or  any  other   instrument  that  is  at  any  time
      convertible  into or exchangeable  for, or otherwise  entitles
      the holder  thereof to receive,  Common  Stock or Common Stock
      Equivalents  entitling any Person to acquire  shares of Common
      Stock,  at a price per share  less than  $0.40  (appropriately
      adjusted for any stock splits,  stock  combinations or similar
      events  occurring  prior to such  time) (if the  holder of the
      Common Stock or Common Stock Equivalent so issued shall at any
      time,  whether by  operation  of purchase  price  adjustments,
      reset provisions,  floating  conversion,  exercise or exchange
      prices or  otherwise,  or due to  warrants,  options or rights
      issued  in  connection  with such  issuance,  be  entitled  to
      receive  shares of  Common  Stock at a price  less than  $0.40
      (appropriately   adjusted   for  any   stock   splits,   stock
      combinations or similar events  occurring prior to such time),
      such  issuance  shall be deemed to have occurred for less than
      $0.40  (appropriately  adjusted  for any stock  splits,  stock
      combinations or similar events occurring prior to such time)),
      then,  at the option of the Holder  for such  exercises  as it
      shall  indicate,  the Exercise  Price shall be multiplied by a
      fraction, the numerator of which shall be the number of shares
      of Common Stock outstanding  immediately prior to the issuance
      of  such  shares  of  Common   Stock  or  such  Common   Stock
      Equivalents  plus the number of shares of Common  Stock  which
      the  offering  price for such shares of Common Stock or Common
      Stock  Equivalents  would purchase at the Exercise Price,  and
      the  denominator  of which  shall be the sum of the  number of
      shares of Common Stock  outstanding  immediately prior to such
      issuance  plus the number of shares of Common  Stock so issued
      or  issuable.  Such  adjustment  shall be made  whenever  such
      Common Stock or Common Stock Equivalents are issued."

Further, the warrants issued in our May 2004 PIPE and our July 2004 PIPE contain
the following  provision  with respect to additional  warrants which we would be
required  to issue to the  investors  at the revised  exercise  price to provide
anti-dilution protection:

      "Number of Warrant Shares.  Simultaneously with any adjustment
      to the Exercise  Price  pursuant to this Section 9, the number
      of Warrant  Shares that may be purchased upon exercise of this
      Warrant  shall be increased or decreased  proportionately,  so
      that  after  such  adjustment  the  aggregate  Exercise  Price
      payable  hereunder for the adjusted  number of Warrant  Shares
      shall be the same as the  aggregate  Exercise  Price in effect
      immediately prior to such adjustment."


                                       4


At a price of $0.40 per share or greater, if Marr and all of the other investors
in the May 2004 PIPE and the July  2004 PIPE  invested  in a  prospective  $16.5
million  transaction  on a  basis  so as to  maintain  their  current  ownership
percentage in Calypte,  they would acquire  approximately  $6.4 million worth of
the shares issued in such  financing.  We do not know if any of these  investors
will participate in a prospective  financing.  The ownership interest in Calypte
of any investors having  participation  rights who elect not to participate in a
prospective  financing  at a price above $0.40 will be  diluted.  The  ownership
interest  of  investors  in the May and  July  2004  PIPE  transactions  will be
partially preserved in a prospective  financing at a price below $0.40 per share
as a result of the  anti-dilution  protection  provisions  of those  agreements,
however,  the investors  would also be required to exercise their  participation
rights at some level to  completely  maintain  their  pre-transaction  ownership
percentage.

Approval of this Proposal  explicitly  authorizes the Board of Directors,  if so
required under the terms of a prospective capital raising transaction,  to issue
shares of Common Stock or  equivalents  in excess of 20% of the number of shares
then currently issued and outstanding according to the specific terms as defined
above and to issue such  additional  shares and both  additional  and  re-priced
warrants as may be required  under the terms of prior  financing  agreements  as
noted above.

The  authority of the Board to proceed  under this proposal will be withdrawn 90
days from the date of  approval of this  Proposal at the Special  Meeting if the
transaction(s) has not closed.

The closing market price of our Common Stock on the October 22, 2004 Record Date
was  $0.33  per  share.  At this  market  price,  we would  issue a  maximum  of
approximately  77.0 million shares of our Common Stock pursuant to a prospective
$16.5 million  financing,  including the shares issuable under the anti-dilution
protection  provisions of our May 2004 and July 2004 PIPEs.  Although we plan to
maximize the pricing of the  prospective  transaction to the benefit of Calypte,
there are no  circumstances  under  which we would  issue more than 135  million
shares of our Common Stock  pursuant to a prospective  $16.5 million  financing,
including  shares of Common Stock which may be or become  issuable upon exercise
of warrants and/or payment of dividends (assuming the prospective transaction is
structured using preferred  stock),  but excluding any shares issuable under the
anti-dilution protection provisions of our previous financings.

ILLUSTRATIVE EXAMPLE

The following  table is presented FOR  ILLUSTRATIVE  PURPOSES ONLY, to calculate
the maximum shares that would be issued under this financing based on the market
price of the stock at the  record  date and the  maximum  discount  of 25%.  See
Certain Risks Related to Our Financial Condition, below.

            SHARES POTENTIALLY ISSUABLE FOR A $16.5 MILLION FINANCING
     BASED ON A MARKET PRICE OF $0.33 AS OF THE OCTOBER 22, 2004 RECORD DATE
                              (shares in millions)

      ---------------------------------------------------------------
                                       MARKET - 25%           MARKET
      ---------------------------------------------------------------
             Share Price                   $0.2475            $0.330
      ---------------------------------------------------------------
      Shares outstanding at
      October 22, 2004                       169.3             169.3

      Shares issuable for $16.5
      million financing (1)                   66.7              50.0

      Anti-dilution shares due                10.3               4.7
      and issuable (2)
                                       -----------------------------
      Shares outstanding after               246.3             224.0
      financing
                                       =============================
      % dilution compared to
      October 22, 2004 shares                 45.5%             32.3%
      outstanding
      ---------------------------------------------------------------

- ----------
(1)   Excludes  warrants  which may be issued with the Common Stock as a unit in
      conjunction with any prospective financing and any additional shares which
      might be required due to a subsequent decline, if any, in the market price
      of the Common  Stock.  We would  reduce the amount of the  offering if the
      pricing of a  prospective  transaction  required the issuance of more than
      135 million shares, including warrant shares.


                                       5


(2)   Anti-dilution  shares  issuable in conjunction  with our May 2004 PIPE and
      our July 2004 PIPE are only calculated at financing prices below $0.40 per
      common share and warrant unit. In addition to the anti-dilution  shares we
      would be  required  to  issue,  we would  also be  required  to reset  the
      exercise price of the currently  outstanding warrants from $0.50 per share
      to $0.4612 per share in the case of a financing at $0.33 or to $0.4287 per
      share in the case of a  financing  at $0.2475.  Further,  we would also be
      required  to  issue   approximately   0.9  million   additional   warrants
      exercisable   at  $0.4612  in  the  case  of  a  financing   at  $0.33  or
      approximately 1.8 million additional  warrants  exercisable at $0.4287 per
      share in the case of a financing at $0.2475.

STOCK EXCHANGE CONSIDERATIONS

Section 713 of the American  Stock  Exchange's  (the  "Exchange")  Company Guide
provides that stockholder approval is required for "a transaction  involving the
sale,  issuance  or  potential  issuance  by the  company  of  common  stock (or
securities  convertible  into  common  stock)  equal  to 20  percent  or more of
presently outstanding stock for less than the greater of book or market value of
the stock."

Further,  as a  condition  of our listing on the  Exchange,  we agreed to obtain
stockholder  approval prior to the listing with the Exchange and issuance of any
such  shares  of our  Common  Stock as may  become  issuable  under the terms of
anti-dilution  protection  provisions  contained in agreements entered into with
respect to our May 2004 and July 2004 PIPEs.

Accordingly,  in  anticipation  that we may  consummate a  capital-raising  PIPE
transaction  that may result in the  issuance  of shares of our Common  Stock in
excess of 20% of the number of shares  then  outstanding  at a  discount  to the
then-current  market  price for our Common  Stock  and/or  that may  trigger the
anti-dilution  protection provisions of the agreements with investors in our May
2004 and July 2004 PIPEs,  we are submitting  this proposal to our  stockholders
and requesting approval thereof.

CERTAIN RISKS RELATED TO OUR FINANCIAL CONDITION

IF,  UNDER  THE  TERMS OF A  PROSPECTIVE  FINANCING,  WE ARE  REQUIRED  TO ISSUE
ADDITIONAL   SHARES  TO  INVESTORS  IN  PRIOR  FINANCINGS  UNDER  THE  TERMS  OF
ANTI-DILUTION PROTECTION PROVISIONS AND DO NOT OBTAIN STOCKHOLDER APPROVAL TO DO
SO AS REQUIRED BY THE  AMERICAN STOCK EXCHANGE, WE MAY BE FORCED TO DE-LIST FROM
THE AMERICAN STOCK EXCHANGE.

The  anti-dilution  protection  provisions  granted to investors in our May 2004
PIPE and July 2004 PIPE  require that we issue  additional  shares of our Common
Stock and reprice and grant additional  warrants to purchase our Common Stock to
those  investors if we issue  additional  shares of stock at less than $0.40 per
share  pursuant to  financing(s)  completed  within one year of the May and July
2004 transactions,  respectively.  As a condition of our listing on the American
Stock Exchange,  we agreed to obtain stockholder  approval prior to listing with
the Exchange and issuing any shares of our Common Stock that may become issuable
under the terms of the anti-dilution  protection  provisions  contained in these
financing  agreements.  If our  stockholders  do not  approve  this  Proposal to
authorize,  if so  required,  the  issuance  of  additional  shares  and new and
re-priced  warrants under the terms of  anti-dilution  protection  provisions in
previous  financing  agreements,  and if a  prospective  financing  triggers the
anti-dilution protection provisions and one or more of the PIPE investors do not
waive their  anti-dilution  rights,  we will be delisted by the  American  Stock
Exchange or be forced to withdraw our listing from the American  Stock  Exchange
in order to complete a  financing  transaction,  at which time our Common  Stock
would again trade on the Over-the Counter Bulletin Board.

IF WE ARE UNABLE TO OBTAIN  ADDITIONAL  FINANCING WHEN REQUIRED,  WE MAY HAVE TO
SIGNIFICANTLY CURTAIL THE SCOPE OF OUR OPERATIONS AND ALTER OUR BUSINESS MODEL.

We believe that the aggregate of approximately  $10.2 million of net proceeds of
our 2004 private  placements and the availability of approximately  $3.6 million
of  borrowing  capability  from 9%  promissory  notes that we may issue  through
December  31, 2004 under the terms of the amended Marr Credit  Facility,  should
our Board of  Directors  unanimously  approve  the  issuance of one or more such


                                       6


notes  before the  commitment  period  expires,  will be adequate to sustain our
operations at expected levels through 2004. There can, however,  be no assurance
that such resources will be adequate. Further, there can be no assurance that we
will be able to achieve expanded acceptance of or realize  significant  revenues
from our current or potential new products,  including our rapid tests,  or that
we will achieve significant  improvements in the efficiency of our manufacturing
processes.  In addition,  there is no assurance  that we will achieve or sustain
profitability  or  positive  cash  flows  in the  future.  We  expect  to  raise
additional capital;  however, we may not be able to obtain additional  financing
on  acceptable  terms,  or at all. We might be  required  to consider  strategic
opportunities,   including  merger,  consolidation,  sale  or  other  comparable
transaction,  to sustain our operations. We do not currently have any agreements
in place with respect to any such additional financing or strategic opportunity,
and there can be no assurance that any such  opportunity will be available to us
on acceptable  terms, or at all. If additional  financing is not available to us
when required or is not available to us on acceptable terms, or we are unable to
arrange a suitable strategic  opportunity,  we will be in significant  financial
jeopardy and we may be unable to continue our operations at current  levels,  or
at all. The terms of a subsequent  financing may involve a change of control and
require the stockholder  approval  requested in this Proposal, due to the size
and  terms  of  the  financing,   including  terms  that  trigger  anti-dilution
protection clauses contained in existing financing  agreements that would result
in substantial dilution to our existing stockholders.

BACKGROUND OF PROPOSAL

PRIOR INCREASES IN AUTHORIZED SHARES

      In September 2001, we requested and received stockholder approval to amend
our Certificate of Incorporation to increase the number of authorized  shares of
our Common Stock from 50 million to 200 million  shares.  In February  2003,  we
requested and received stockholder approval for a further increase in authorized
shares of Common Stock from 200 million to 800 million  shares.  Our Amended and
Restated  Certificate of Incorporation  currently authorizes the issuance of 805
million shares, of which 800 million are authorized for issuance as Common Stock
and 5 million are authorized for issuance as Preferred Stock.

      As of October 22, 2004,  we had 800 million  shares of  authorized  common
stock  and   approximately  169  million  shares  of  common  stock  issued  and
outstanding.  We will continue to have 5 million  authorized shares of preferred
stock.  Authorized but unissued shares are available for issuance, and we expect
to issue such shares in future financing transactions.

      In the past, we have  maintained  our  operations  through the issuance of
equity  and  convertible  securities.  Although  we  currently  do not  have any
definitive plans for the issuance of a substantial  number of shares,  we expect
that we  will  be  required  to  issue a  significant  number  to  complete  the
prospective  financing  contemplated  in the  Proposal  herein,  in which we are
requesting stockholder  authorization to enter into an equity financing of up to
$16.5  million.  Depending  on the  price  of the  Common  Stock  implicit  in a
prospective  financing,  such a transaction  could require us to issue shares of
Common Stock in an amount in excess of 20% of our currently  outstanding  shares
of Common Stock. We will, however,  issue no more than 135 million shares of our
Common Stock pursuant to a $16.5 million  financing,  including shares of Common
Stock which may be or become  issuable upon exercise of warrants  and/or payment
of dividends (assuming the prospective transaction is structured using preferred
stock). Further, such a prospective financing may require us to issue additional
shares  of our  Common  Stock  to  investors  in  previous  financings  based on
anti-dilution  protection  clauses  in those  investment  agreements.  If we are
successful in arranging additional equity-related financing and issue additional
shares of our common stock, the ownership  interest of holders of Calypte common
stock will be diluted.

            The remainder of this page is intentionally left blank.


                                       7


USAGE OF SHARES

      At December 31, 2001, we had issued  approximately  1.3 million  shares of
our Common Stock.  As of the October 22, 2004 record date, we had  approximately
169.3  million  shares  outstanding,  primarily  as a  result  of our  financing
activities and the issuance of options, warrants and stock grants. The following
table summarizes these financing activities by major category and the subsequent
table  provides the details of these  financings.  All amounts are in thousands,
except per share closing prices in the second table.

         SUMMARY OF RECENT FINANCINGS - JANUARY 2002 TO OCTOBER 22 2004

                                                                    TOTAL
                                           GROSS       NET          SHARES
      FINANCING SOURCE                     PROCEEDS    PROCEEDS     ISSUES
      ----------------------------------   --------    --------     ---------
      Bristol 12% Convertible Debentures   $   562     $    505       1,476.1
      and Warrants
      8% Convertible Notes                   3,232        2,594      46,084.3
      Other Restart Financings                 750          730       2,720.3
      Mercator 12% and 10% Debentures (1)    4,550        3,650      37,529.5
      Marr 2003 Private Placements          12,500       11,900      28,333.3
      May 2004 PIPE                          9,300        8,769      23,250.0
      July 2004 PIPE                         1,488        1,384       3,720.0
                                           --------     -------     ---------
         Total                             $ 32,382     $29,532     143,113.5
                                           ========     =======     =========

      (1)   At October 22, 2004,  the holders have  converted all but $60,000 of
            principal of the convertible debentures issued since September 2002.
            Based  on  current  market  prices,  we  estimate  that we  would be
            required to issue approximately 0.2 million additional shares of our
            common  stock  if the  holders  elected  to  convert  the  remaining
            principal and accrued interest of their debentures at this time. The
            holders of these 12% convertible debentures claim a transaction date
            which we  dispute.  These  debentures  have  not yet been  converted
            pending resolution of the transaction date dispute, which may impact
            the  number of shares of our stock to which the  holder is  entitled
            upon conversion. See Note 12 to Detail of Financings.

            The remainder of this page is intentionally left blank.


                                       8




                                       DETAIL OF RECENT FINANCINGS - JANUARY 2002 TO OCTOBER 22, 2004

                                                                                                   CALYPTE
FINANCING TYPE AND                        CONVERSION         GROSS      NET          TRANSACTION   CLOSING      SHARES
INVESTOR (1)                              FEATURE            PROCEEDS   PROCEEDS     DATE          PRICE        ISSUED/$REDEEMED(3)
- ---------------------------------------   ---------------    --------   --------     -----------   ---------    -----------------
                                                                                              
12% CONVERTIBLE DEBENTURE AND WARRANTS
Bristol Investment Fund, Ltd.               Lesser of (i)    $    425                2/11/02       $    7.50        1,019.4/ $525
                                               60% of the         100                5/10/02       $    0.90
                                                             --------
                                             average of 3    $    525   $    468
                                           lowest closing
                                           bid prices for
                                                  22 days
                                                preceding
                                            conversion or
                                                (ii)$1.50

Class A Warrant                             Lesser of (i)    $      4   $      4     2/11/02       $    7.50            56.7/ N/A
                                               70% of the
                                               average of
                                                 lowest 3
                                           trading prices
                                              for 20 days
                                                preceding
                                            conversion or
                                                (ii)$3.45

Class B Warrant                           Lesser of (i)      $     33   $     33     2/11/02       $    7.50             400/ N/A
                                                             --------   --------                                -----------------
                                               70% of the
                                               average of
                                                 lowest 3
                                          trading pricing
                                              for 20 days
                                                preceding
                                            conversion or
                                              (ii) $6.45.
      Total Bristol                                          $    562   $    505                                    1,476.1/ $525
                                                             ========   ========                                =================

8% CONVERTIBLE NOTES

Alpha Capital Aktiengesellshaft                 Lesser of    $    500                5/24/02       $    3.60        7,260.7/ $500
Stonestreet Limited Partnership              (i) $3.00 or    $    500                5/24/02       $    3.60        7,075.7/ $500
Filter International Ltd.                     (ii) 70% of    $    150                5/24/02       $    3.60        2,452.4/ $150
Camden International Ltd.                  the average of    $    350                5/24/02       $    3.60        5,279.1/ $350
Domino International Ltd.                    the 3 lowest    $    150                5/24/02       $    3.60        1,767.4/ $150
Thunderbird Global Corporation              trades for 30    $     75                5/24/02       $    3.60         1,083.1/ $75
BNC Bach International Ltd.                          days    $    200                5/24/02       $    3.60        2,463.8/ $200
Excalibur Limited Partnership                   preceding    $    200                5/24/02       $    3.60        1,678.9/ $200
Standard Resources Ltd.                        conversion    $    100                5/24/02       $    3.60        1,542.5/ $100
SDS Capital International Ltd.                               $    300                7/10/02       $   10.20        4,189.8/ $300
Camden International Ltd.                                    $    100                7/10/02       $   10.20        1,707.9/ $100
Excalibur Limited Partnership                                $    250                7/24/02       $    6.60        4,238.3/ $250
Stonestreet Limited Partnership                              $    250                8/21/02       $    3.90        4,042.2/ $250
Alpha Capital Aktiengesellshaft                              $    107                 5/9/03       $    0.63        1,302.5/ $107
                                                             --------                                           -----------------
   Total 8% Convertible Notes                                $  3,232   $  2,594                                 46,084.3/ $3,232
                                                             ========   ========                                =================



                                        9




                                                                                                   CALYPTE
FINANCING TYPE AND                        CONVERSION         GROSS      NET          TRANSACTION   CLOSING      SHARES
INVESTOR (1)                              FEATURE            PROCEEDS   PROCEEDS     DATE          PRICE        ISSUED/$REDEEMED(3)
- ---------------------------------------   ---------------    --------   --------     -----------   ---------    -----------------
                                                                                              
OTHER RESTART FINANCINGS:

10% CONVERTIBLE NOTE
BNC Bach International Ltd. (Note: on          50% of the    $    150   $    150     5/14/02       $    4.20        2,217.8/ $150
7/14/02 the maturity date was extended       average of 3                                          $10.80 on
until 12/31/02; on December 27, 2002,      lowest closing                                          7/14/02;
the maturity date was extended until       bid prices for                                          $1.92 on
January 15, 2003; on January 15, 2003             22 days                                          12/27/02;
the maturity date was extended until            preceding                                          $1.80 on
March 17, 2003, on March 17, 2003 the          conversion                                          1/15/03;
maturity date was extended until April                                                             $1.50 on
4, 2003; on April 2, 2003, the                                                                     3/17/03;
maturity date was  extended until May                                                              $0.99 on
5, 2003; on April 30, 2003, the                                                                    4/2/03
maturity date was subsequently                                                                     $0.75 on
extended until May 10, 2004)(5)                                                                    4/30/03

8% CONVERTIBLE DEBENTURES
Su So                                          80% of the    $    100   $     90     6/17/02       $    4.20       36.7 (4)/ $100
                                             lower of the
                                          average closing
                                             bid or trade
                                          price for the 5
                                           days preceding
                                          conversion, but
                                            not less than
                                                    $3.00

Jason Arasheben                                70% of the    $    100   $     90     7/03/02       $    8.10       15.8 (4)/ $100
                                             lower of the
                                          average closing
                                             bid or trade
                                          price for the 5
                                           days preceding
                                          conversion, but
                                            not less than
                                                    $3.00

PIPE AT $1.50 PER SHARE
Careen Ltd.                                     $1.50 per    $    200   $    200     8/28/02       $    4.80           225.0/ N/A
Caledonia Corporate Group Limited                   share    $    200   $    200     8/28/02       $    4.80           225.0/ N/A
                                                             --------   --------                                -----------------

    Total Other Restart Financings                           $    750   $    730                                    2,720.3/ $350
                                                             ========   ========                                =================



                                       10




                                                                                                   CALYPTE
FINANCING TYPE AND                        CONVERSION         GROSS      NET          TRANSACTION   CLOSING      SHARES
INVESTOR (1)                              FEATURE            PROCEEDS   PROCEEDS     DATE          PRICE        ISSUED/$REDEEMED(3)
- ---------------------------------------   ---------------    --------   --------     -----------   ---------    -----------------
                                                                                              
MERCATOR 12% AND 10% DEBENTURES (2)(3)

12% CONVERTIBLE DEBENTURES
Mercator Momentum Fund, L.P. ($2,000 total     85% of the    $    550   $    345(6)  9/12/02       $    3.00      4,866.4(4)/$550
commitment)                                average of the
                                                 3 lowest
Mercator assigned its rights to:           trading prices
   Alpha Capital AG                            for the 20         250        250     7/24/03       $   0.115        2,673.8/ $250
   Gamma Opportunity Capital Partners, LP    trading days         250        250     7/24/03       $   0.115        2,685.6/ $250
   Goldplate Investment Partners                preceding
   Marr Technologies, B.V. (11)            conversion (8)         250        250     7/24/03       $   0.115        2,673.8/ $250
                                                                  570        570      9/1/03       $   0.498        5,181.8/ $570
                                                             --------   --------
   Dr. Khalid Ahmed                                             1,870      1,665
   Roger Suyama                                                    50         50     10/2/03       $   1.310            84.6/ $50
   Logisticorp, Inc.                                               20         20     10/2/03       $   1.310            33.8/ $20
   Southwest Resource Preservation Inc.                            20         20     10/2/03 (12)  $   1.310                   --
                                                                                     10/2/03 (12)  $   1.310
                                                                   40         40                                               --
                                                             --------   --------                                -----------------
                                                             $  2,000   $  1,795                                 18,199.8/ $1,940
                                                             --------   --------                                -----------------

Mercator Momentum Fund, L.P.                   80% of the    $    300   $    260     10/22/02      $    3.90              0/ $300(7)
                                           average of the
                                                 3 lowest
                                           trading prices
                                               for the 20
                                             trading days
                                                preceding
                                          conversion, but
                                            not less than
                                                    $1.50

Mercator Momentum Fund L.P.  (10)              70% of the    $    300   $    245     4/29/03       $   0.825        3,475.7/ $300
                                           average of the
                                                 3 lowest
                                           trading prices
                                               for the 20
                                             trading days
                                                preceding
                                          conversion, but
                                            not more than
                                                    $1.20

Mercator warrant                          $3.00 per share    $      0   $      0     10/22/02      $    3.90                    0

10% CONVERTIBLE DEBENTURES

Mercator Focus Fund, L.P. (10)                 80% of the    $  1,000   $    510(6)   1/14/03       $    1.92      7,941.1/ $1,000
                                           average of the
                                                 3 lowest
                                           trading prices
                                               for the 20
                                             trading days
                                                preceding
                                          conversion, but
                                            not more than
                                                    $3.00




                                       11




                                                                                                   CALYPTE
FINANCING TYPE AND                        CONVERSION         GROSS      NET          TRANSACTION   CLOSING      SHARES
INVESTOR (1)                              FEATURE            PROCEEDS   PROCEEDS     DATE          PRICE        ISSUED/$REDEEMED(3)
- ---------------------------------------   ---------------    --------   --------     -----------   ---------    -----------------
                                                                                              
Mercator Momentum Fund, L.P. (10)              80% of the    $    450   $    440     1/30/03       $    1.86        2,857.7/ $450
                                           average of the
                                                 3 lowest
                                           trading prices
                                               for the 20
                                             trading days
                                                preceding
                                          conversion, but
                                            not more than
                                                    $3.00
Mercator Focus Fund, L.P. (10)                               $    400                3/13/03       $    1.47        3,428.9/ $400
  Mercator Momentum Fund III, L.P.             65% of the         100                                               1,626.3/ $100
                                                             --------                                           -----------------
                                           average of the    $    500   $    400                                    5,055.2/ $500
                                                             --------   --------                                -----------------
                                                 3 lowest
                                           trading prices
                                               for the 20
                                             trading days
                                                preceding
                                          conversion, but
                                            not more than
                                                    $2.10
   Total Mercator Debentures                                 $  4,550   $  3,650                                 37,529.5/ $4,490
                                                             ========   ========                                =================

MARR PRIVATE PLACEMENTS

        PIPE at $0.30 per share
Marr Technologies B.V. (9)(11)                  $0.30 per    $  2,500   $  2,300     8/1/03        $   0.152              8,333.3
                                                    share
        PIPE at $0.50 per share
Marr Technologies B.V. (9)(11)                  $0.50 per    $ 10,000   $  9,600     9/1/03        $   0.498             20,000.0
                                                             --------   --------                                -----------------
                                                    share
  Total Marr Private Placements                              $ 12,500   $ 11,900                                         28,333.3
                                                             ========   ========                                =================

MAY 2004 PRIVATE PLACEMENT

  PIPE AT $0.40 PER SHARE (13)                      Units
    SF Capital Partners LP                      issued at    $  4,000   $  3,720     5/28/04       $    0.50             10,000.0
    Marr Technologies BV                           $0.40,       3,000      2,910     5/28/04       $    0.50              7,500.0
    Proximity Fund LP                           including         500        465     5/28/04       $    0.50              1,250.0
    Proximity Partners LP                          shares         500        465     5/28/04       $    0.50              1,250.0
    MTB Small Cap Growth Fund                  and 5 year         500        465     5/28/04       $    0.50              1,250.0
    MTB Multi Cap Growth Fund                     warrant         500        465     5/28/04       $    0.50              1,250.0
    Bridges & PIPES LLC                       exercisable         300        279     5/28/04       $    0.50                750.0
                                                             --------   --------
                                             at $0.50 per
        Total May 2004 PIPE                         share    $  9,300   $  8,769                                         23,250.0
                                                             ========   ========                                =================

JULY 2004 PRIVATE PLACEMENT

  PIPE AT $0.40 PER SHARE (13)                      Units
    Sunrise Equity Partners, L.P.               issued at    $    750   $    698     7/9/04        $   0.615              1,875.0
    Amnon Mandelbaum                               $0.40,          80         74     7/9/04        $   0.615                200.0
    David I. Goodfriend                         including           8          7     7/9/04        $   0.615                 20.0
    TCMP3 Partners                                 shares         150        140     7/9/04        $   0.615                375.0
    United Capital Partners, LLC               and 5 year         500        465     7/9/04        $   0.615              1,250.0
                                                             --------   --------                                -----------------
                                                  warrant
        Total July 2004 PIPE                  exercisable    $  1,488   $  1,384                                          3,720.0
                                                             ========   ========                                =================
                                             at $0.50 per
                                                    share



                                       12


      (1) The Bristol  Debentures and Warrants,  the 8% Convertible  Notes,  the
Other Restart Financings,  the Mercator 12% and 10% Debentures and warrants, and
the Common Stock underlying  MTBV's 2003 PIPE's,  the May 2004 and the July 2004
PIPEs were issued under  exemptions  provided by  Regulation S or  Regulation D.
With the  exception  of Marr  Technologies  B.V.,  which is an  affiliate of the
Company  based  on  its  August  and  September   2003  PIPE   investments   and
participation  in the May 2004 PIPE, none of the entities listed above is or has
been an affiliate of the Company.  Other than Marr Technologies B.V., all of the
listed  investors  were  subject  to  ownership  limitations  restricting  their
ownership  of our stock to a maximum of 4.9% or 9.9%,  depending on the specific
agreement.

      (2) At October 22,  2004,  the holders have  converted  all but $60,000 of
principal of the convertible  debentures  issued since September 2002.  Based on
current  market  prices,  we  estimate  that  we  would  be  required  to  issue
approximately  0.2 million  additional shares of our common stock if the holders
elected to  convert  the  remaining  principal  and  accrued  interest  of their
debentures at this time. See also Note 12.

      (3) On July 18, 2003, the  registration  statement for  52,500,000  shares
underlying the 8% Convertible Notes, the Other Restart Financings and $1,300,000
of the Mercator 12% and 10% Convertible  Debentures  became  effective (File No.
333-106862).  As a  result  of a  decline  in the  market  price  of  our  stock
subsequent to the effective date of the July 2003  registration  statement,  the
number of shares  registered was insufficient to permit the complete  conversion
of the notes and  debentures  into  registered  shares.  The  shares  underlying
certain of the convertible securities have become eligible for resale under Rule
144,  and certain  investors  have availed  themselves  of that  eligibility  to
convert  restricted  shares issued  pursuant to  conversions  into  free-trading
shares.  On July 8, 2004,  the  registration  statement  for  83,056,050  shares
underlying Marr Private  Placements,  the May 2004 PIPE, certain of the Mercator
12%  Convertible  Debentures,   approximately  12.2  million  additional  shares
attributable to financings included in the July 2003 registration  statement and
approximately  3.3 million shares issued or issuable to vendors  consultants and
other  parties who agreed to accept  shares of our Common  Stock in lieu of cash
became  effective  (File No.  333-116491).  On July 28, 2004,  the  registration
statement for 6,472,800 shares of our Common Stock underlying the July 2004 PIPE
and related warrants became effective (File No. 333-117439).

      (4) Includes fee shares.

      (5) On April 30,  2003,  when the  market  price of the  common  stock was
$0.75,  we and BNC Bach amended the  conversion  price to eliminate a conversion
price ceiling of $1.50 per share and to increase the discount  applicable to the
conversion  price  from  40% to 50%.  In  return  for this  modification  of the
conversion  price,  BNC Bach agreed to extend the maturity of the note until May
10, 2004. BNC Bach subsequently  converted the outstanding principal and accrued
interest into shares of our common stock.

      (6) Reflects a 10% cash commitment fee on the entire $2 million commitment
paid to The Mercator  Group less  additional  fees and  expenses.  We registered
shares underlying $1,300,000 of the total $2,000,000 commitment in July 2003 and
the shares  underlying  the final  $700,000 of this  commitment in our June 2004
registration statement.

      (7) In  conjunction  with the  issuance of the $1 million 10%  convertible
debenture to Mercator  Focus Fund,  L.P., we used the proceeds to repay the $0.3
million  outstanding   principal  balance  of  the  12%  convertible   debenture
previously  issued to Mercator  Momentum Fund, L.P. plus accrued  interest.  The
balance of costs incurred represents transactional and legal fees.

      (8) On March 31,  2003,  when the  market  price of our  Common  Stock was
$0.885, we amended the conversion price to eliminate a conversion price floor of
$1.50 per share in return  for an  extension  of time in which to  register  the
shares of common stock underlying the various Mercator financings.

      (9) The Securities Purchase  Agreements for both transactions  between the
Company  and  Marr   Technologies   B.V.  required  that  we  provide  cost-free
registration  rights to Marr;  however,  Marr was subject to a one-year  lock-up
provision following the transaction date with respect to the shares purchased.

      (10) On January 14,  2004,  when the market  price of our common stock was
$0.60, we extended the maturity date of the following  debentures until July 14,
2004:

      o     10% Convertible  Debenture dated January 14, 2003 issued to Mercator
            Focus Fund, LP
      o     10% Convertible  Debenture dated January 30, 2003 issued to Mercator
            Momentum Fund, LP
      o     10% Convertible  Debentures  dated March 13, 2003 issued to Mercator
            Focus Fund, and
      o     12%  Convertible  Debenture  dated April 29, 2003 issued to Mercator
            Momentum Fund, LP.

In return for the extension of the maturity dates, we agreed to pay an extension
fee equal to 2% of the outstanding principal balance per month until the earlier
of the extended maturity date or conversion.  The extension fee is payable 1% in
cash and 1% in shares of our  common  stock.  Additionally,  we agreed to file a
registration  statement  including  the  shares  potentially  applicable  to the
conversion  of the  outstanding  debenture  balances  by no later than April 29,
2004.  On April 23, 2004,  when the market price of our Common Stock was $0.625,
we and the various Mercator Funds agreed to extend until May 14, 2004 the period
for filing the registration statement including the shares issued or potentially
issuable upon  conversion.  On May 7, 2004,  when the market price of our common
stock was $0.48 per share,  we and the various  Mercator Funds agreed to further
extend  from May 14,  2004  until 21 days  following  the  closing  of a private
placement  of equity  financing  of at least  $5,000,000,  but in any case to no
later  than  June 30,  2004,  the  period  in which  we are  required  to file a
registration   statement   including  shares  of  our  common  stock  issued  or
potentially issuable upon conversion.  Such shares were included in our June 15,
2004 registration  statement,  which was declared effective on July 8, 2004. All
of the subject  convertible  debentures  were  converted  prior to the  extended
maturity date.


                                       13


      (11) On January 23,  2004,  when the market  price of our common stock was
$0.695, we and Marr agreed to extend the registration rights period attributable
to  5,181,818  shares of our common  stock  issued in  conjunction  with  Marr's
conversion  of  $570,000  principal  amount  of the  Company's  12%  Convertible
Debentures  from  February  27,  2004 to  April  29,  2004.  In  return  for the
extension,  we agreed to include in our next registration statement an aggregate
of 28,333,333  shares of our common stock purchased by Marr in PIPE transactions
in the third  quarter of 2003.  On April 23 2004,  when the market  price of the
Common Stock was $0.625, MTBV agreed to extend until May 14, 2004 the period for
filing the  registration  statement  including  the  shares  issued to MTBV upon
conversion of the 12% convertible  debenture and in the 2003 PIPE  transactions.
On May 7 2004,  when the market  price of our common  stock was $0.48 per share,
MTBV  agreed to further  extend from May 14,  2004 until 21 days  following  the
closing of a private placement of equity financing of at least  $5,000,000,  but
in any case to no later than June 30, 2004,  the period in which we are required
to file a registration  statement including shares of our common stock issued to
MTBV  upon  conversion  of the 12%  convertible  debenture  and in the 2003 PIPE
transactions.  Such  shares  were  included  in our June 15,  2004  registration
statement, which was declared effective on July 8, 2004.

      (12) The  holders  claim an  earlier  transaction  date with  respect to a
conversion of the debentures,  which we dispute.  These  debentures have not yet
been  converted.   Assuming  immediate  conversion  at  the  earlier,   disputed
transaction  date,  the number of shares of common stock issuable to Logisticorp
and Southwest Resource Preservation would be 213,903 and 427,807,  respectively.
While  reserving  our rights with respect to the number of shares  calculated as
issuable based on the disputed  transaction  date, we registered  that number of
shares of  Common  Stock in our June 15,  2004  registration  statement  pending
resolution  of the dispute.  The ultimate  resolution  of the  transaction  date
dispute may  determine  the number of shares of our stock to which the holder is
entitled upon conversion.

      (13) In  conjunction  with the May 2004 PIPE,  we issued to each  investor
5-year  warrants at $0.50 per share to purchase shares of our common stock in an
amount  equal to 35% of the  number  of shares  purchased  by the  investor.  In
conjunction  with the July 2004 PIPE, we issued to each investor 5-year warrants
at $0.50 per share to purchase  shares of our common stock in an amount equal to
70% of the  number  of shares  purchased  by the  investor.  The  shares  issued
pursuant  to the May 2004 PIPE and the July 2004 PIPE and the  related  warrants
for each have an anti-dilution  feature that will require us to issue additional
shares to the PIPE investors and modify their warrants if we subsequently  issue
additional  equity at a per share  price of less than  $0.40 for a period of one
year  from  the  respective  closing  dates,  except  under  the  provisions  of
previously  outstanding  convertible  debt,  option plans,  or option or warrant
agreements.

WARRANTS, OPTIONS AND STOCK GRANTS FROM BOARD OF DIRECTORS APPROVED PLANS

Since January 2002, we have entered into various  contracts and agreements  with
consultants  who have agreed to accept payment for their services in the form of
warrants,  options and/or stock grants.  We have obtained various services under
these arrangements,  including legal,  financial,  business advisory,  and other
services  including  business  introductions  and  arrangements  with respect to
potential  domestic and  international  product placement and the development of
potentially  synergistic  relationships with appropriate public service or other
governmental and  non-governmental  organizations.  We have generally issued the
warrants at a discount to the then-current  market price and have registered the
shares   underlying  the  warrants,   options  and  stock  grants  on  Form  S-8
Registration  Statements for resale by the  consultants.  We have, since January
2002, issued  approximately  10.4 million shares of our common stock as a result
of warrant or option  exercises  and stock  grants  related to these  consulting
agreements  and related  Registration  Statements,  of which  approximately  7.9
million shares were issued during 2003.

In May 2002, we issued  warrants and options to purchase  633,333  shares of our
common stock under  agreements  with  consultants to perform  legal,  financial,
business  advisory  and  other  services  associated  with  the  restart  of our
operations.  The warrants were issued at $0.45 per share on May 9, 2002 when the
market price of our common stock was $0.90 per share.  The option was granted at
$0.90 per share on May 10,  2002,  when the market price of our common stock was
$0.90 per share. All of the warrant and option grants were  non-forfeitable  and
fully-vested  at the date of  issuance  and were  registered  for  resale by the
consultants  under Form S-8.  The  consultants  exercised  all the  warrants and
options and we issued 633,333 shares and received proceeds of $292,500.  All but
one of the consulting  agreements  discussed above expired in August 2002 and we
entered  into  new  agreements  with  certain  of  the  consultants  for  legal,
financial,  business advisory,  and other services  including  introductions and
arrangements  with  respect to  potential  domestic  and  international  product
development  of  synergistic   relationships  with  appropriate  public  service
organizations.  In November 2002, we issued warrants to purchase  950,000 shares
of our  common  stock  and  stock  grants  for  70,000  shares  of our  stock to


                                       14


consultants under the terms of these new agreements.  We issued 350,000 warrants
at an exercise  price of $1.50 per share on  November  1, 2002,  when the market
price of our stock was $4.20 per share. We issued an additional 600,000 warrants
at an exercise price of $1.50 on November 20, 2002, when the market price of our
common  stock was $2.70.  All of the  warrant  grants were  non-forfeitable  and
fully-vested  at the date of  issuance  and were  registered  for  resale by the
consultants  under Form S-8. By February 2003, the consultants had exercised all
the warrants and we had received aggregate proceeds of $1.425 million. We issued
986,667  shares of our common  stock  pursuant to the  exercises of the November
2002 warrant and stock grants. In January and February 2003, we entered into new
contracts and extended  certain other  contracts  with existing  consultants  to
perform services as described above. On February 14, 2003, when the market price
of our stock was $2.01,  we issued  warrants  exercisable at $1.50 per share and
stock  grants  for an  aggregate  of  975,216  shares  of our  common  stock  as
compensation  for  these  services.   The  warrants  were   non-cancelable   and
fully-vested  at the date of issuance.  By May 31,  2003,  the  consultants  had
exercised  warrants  to  purchase  all of the shares  granted to them and we had
received proceeds of $0.8 million.

During March 2003, when the market price of our stock ranged from $1.32 to $1.50
per share,  we issued  warrants  exercisable at $0.75 per share and stock grants
for an aggregate of 1,350,400 as compensation for services under new or extended
contracts.  The warrants were  non-cancelable  and  fully-vested  at the date of
issuance.  By May 31, 2003, the consultants  had exercised  warrants to purchase
all of the shares granted to them and we had received  proceeds of approximately
$0.9 million.

In April  2003,  when the price of our stock  ranged  from  $0.81 to $0.885  per
share, we entered into additional  contracts,  extended certain  contracts,  and
modified certain other contracts with existing  consultants who agreed to settle
a portion of the  outstanding  balance due for services under their contracts in
stock.  We issued  warrants at $0.75 per share and stock grants for an aggregate
of 1,490,600  shares of our common stock as compensation or settlement for these
services.  The warrants  were  non-cancelable  and  fully-vested  at the date of
issuance.  By May 31, 2003, the consultants  had exercised  warrants to purchase
all of the shares granted to them and we had received  proceeds of approximately
$0.1 million.

In May 2003, when the price of our stock ranged from $0.552 to $0.576 per share,
we again entered into new contracts,  extended certain  contracts,  and modified
certain other contracts with existing consultants who agreed to settle a portion
of the  outstanding  balance due for services under their contracts in shares of
stock.  We issued  warrants at $0.30 per share and stock grants for an aggregate
of 2,080,305  shares of our common stock as compensation or settlement for these
services.  The warrants  were  non-cancelable  and  fully-vested  at the date of
issuance.  By September 30, 2003,  the  consultants  had  exercised  warrants to
purchase  all of the shares  granted  to them and we had  received  proceeds  of
approximately $0.5 million.

In July 2003,  when the price of our stock ranged from $0.11 to $0.30 per share,
we  extended a contract  for  consulting  and other  services  and  granted  the
consultant  a warrant to purchase  722,500  shares of our common stock at 50% of
the closing market price on the date of any exercise as  compensation  under the
contract.  The warrant was granted as fully-vested  and expired on September 30,
2003. By September 30, 2003,  the consultant had exercised the entire warrant at
prices  ranging  from $0.08 to $0.61 per share and we had  received  proceeds of
approximately  $0.4  million.  Also during July 2003,  we issued stock grants to
consultants  for  an  aggregate  of  356,344  shares  of  our  common  stock  as
compensation under their contracts.

On August 20, 2003,  when the price of our stock was $0.18 per share,  we issued
consulting contracts to two new consultants pursuant to which we issued warrants
for 100,000  shares each,  exercisable  at $0.18 per share.  The  warrants  were
non-cancelable  and  fully-vested  at  the  date  of  issuance.   To  date,  the
consultants have exercised none of the warrants.

In  September  2003,  when the price of our stock ranged from $0.50 to $1.80 per
share,  we  issued  an  aggregate  of  800,000  shares  of our  common  stock to
consultants  and other  service  providers who agreed to take shares of stock in
lieu of cash as compensation under their contracts.

In October and November  2003,  when the price of our stock ranged from $0.53 to
$1.65 per share, we issued an aggregate of 125,000 shares of our common stock to
consultants  and other  service  providers who agreed to take shares of stock in
lieu of cash as compensation under their contracts.

In  February  2004,  when the price of our stock was $0.67 per share,  we issued
500,000  shares of our  common  stock to a  consultant  who had agreed to accept
shares of stock as a portion of its compensation  under a consulting  agreement.
We issued  approximately 67,000 additional shares of our common stock during the
first  quarter  of 2004 to  another  consultant  under the terms of a  long-term
consulting agreement.


                                       15


In May  2004,  when the  price of our  stock was  $0.465  per  share,  we issued
warrants to purchase  150,000 shares of our common stock at an exercise price of
$0.50 as a portion of the compensation under a consulting contract. The warrants
were  exercisable  immediately  and remain so for a period of five years.  These
warrants do not have registration rights and have not been exercised to date.

In June 2004, when the price of our stock was $0.52 per share, we issued 250,000
shares of our common  stock to a consultant  who had agreed to accept  shares of
stock as compensation under a consulting agreement.

Further,  in June 2003,  our Board of Directors  authorized  and we registered a
total of  10,000,000  shares of our common  stock under a Form S-8  Registration
Statement for issuance under our 2003 Non-Qualified Stock Option Plan (the "2003
Plan"). Under the 2003 Plan, we awarded stock options at market or at a discount
to market or direct stock grants to  consultants  in  consideration  of services
rendered  to the  Company.  Between  July 2003 and  December  2003,  we  granted
consultants  options  to  purchase  7,227,500  shares of our  Common  Stock at a
weighted  average price of $0.16 per share. The consultants had exercised all of
the options by December 31, 2003. Between July 2003 and August 2004, we issued a
total of 2,772,500  shares of our Common Stock as direct stock grants to various
consultants. All of the shares registered under the 2003 Plan are now issued and
outstanding.

To conserve cash and to obtain goods and  services,  the Company may continue to
issue  options and warrants at discounts to market or issue direct stock grants.
In the event that the Company  issues  additional  options and  warrants,  it is
anticipated that the securities will contain cost-free registration rights which
will be granted to holders of the  options and  warrants,  and that there may be
dilution to the Company's existing stockholders.

LICENSE AGREEMENT AND TECHNOLOGY TRANSFER AGREEMENT  ("LICENSE  AGREEMENT") WITH
ANI BIOTECH OY

On September  30, 2004,  when the market price of our Common Stock was $0.39 per
share and pursuant to  Regulation  S, we entered  into a  licensing,  technology
transfer and equipment  purchase  agreement with Ani Biotech Oy ("Ani") pursuant
to  which  we  are  required  to pay to Ani  an  aggregate  of  1,232,840  Euros
(approximately  US  $1,500,000)  in either our  Common  Stock or cash to acquire
certain licenses and manufacturing  equipment.  On September 30, 2004, we issued
1,172,205  restricted shares of our Common Stock to Ani,  representing the first
installment  under the License  Agreement.  The subsequent  installments will be
payable in shares of our Common Stock or in cash,  over the next several  months
following the  effectiveness  of a registration  statement on Form SB-2 filed on
October 8, 2004 (SEC File No.: 333-119646).  The License Agreement provides that
we will issue  shares of our Common Stock to Ani at a price equal to the average
closing price of our Common Stock as quoted on the American  Stock  Exchange for
the five days  immediately  preceding the transfer,  but not less than $0.40 per
share.  The License  Agreement  further  provides that the conversion  rate from
Euros into US dollars will be the 12 Noon Eastern Time buying rate on the day of
the transfer as reported by the Federal  Reserve  Bank of New York.  The October
registration statement included a total of 4,200,000 shares of our Common Stock,
which  assumes  that all  payments  are made in shares of our Common  Stock at a
share price of $0.40 and that the current  exchange  rate  between  Euros and US
dollars  will not  fluctuate  by more  than  10%  from its  level at the time of
filing.

MARR CREDIT FACILITY

On November  13,  2003,  when the market price of our common stock was $0.88 per
share, the Company and Marr Technologies BV ("Marr"),  our largest  stockholder,
entered  into an agreement in which Marr agreed to provide us up to an aggregate
of $10,000,000 (the "Marr Credit Facility")  pursuant to promissory notes we may
issue to Marr on an as-needed basis (the "Notes"). Each Note would bear interest
at the rate of 5% per annum and have a 12-month term.  The Marr Credit  Facility
was available during the period beginning on February 28, 2004 and ending on May
31, 2004.  The  aggregate  amount  available  under the Marr Credit  Facility is
proportionally  reduced by the amount of any equity  financing we obtain  during
the term of the Marr Credit Facility.  Marr has participation rights in any such
equity  financing  on the same  terms as the other  investors.  The Marr  Credit
Facility provided for earlier  termination as of March 31, 2004, if we failed to
have our common  stock  listed on an  established  stock  exchange by that date.
Moreover,   upon  the  failure  to  obtain  such  stock  exchange  listing,  any
outstanding  Notes would be due and payable on April 30, 2004. As  consideration
for the Marr Credit Facility,  we issued to a party designated by Marr a warrant
to purchase 375,000 shares of its common stock at an exercise price of $0.80 per
share.  The  warrant is  immediately  exercisable  and  expires  two years after
issuance, on November 12, 2005.


                                       16


On March 19,  2004,  when the market  price of our  common  stock was $0.575 per
share,  we and Marr amended the Marr Credit  Facility to increase the  aggregate
amount  available under the Marr Credit Facility to $15,000,000 and to eliminate
the  termination  provision  upon  failure to have our common stock listed on an
established  stock exchange by March 31, 2004. As additional  consideration  for
the amendment of the Marr Credit  Facility,  we issued to a party  designated by
Marr an additional  warrant to purchase 400,000 shares of our common stock at an
exercise price of $0.46 per share.  This warrant is immediately  exercisable and
expires two years from its date of issuance, on March 18, 2006.

On May 26, 2004,  when the market price of our Common Stock was $0.46 per share,
we and Marr again amended the Marr Credit Facility whereby Marr has committed to
purchase up to $5,000,000 of Promissory Notes that we may issue through December
31, 2004, should our Board of Directors  unanimously approve the issuance of one
or more such notes  before  the  commitment  period  expires.  Any Notes  issued
pursuant to this second  amendment  will bear  interest at 9% per annum and will
have a maturity date of May 31, 2005. The $5,000,000  commitment available under
the  amended  Marr  Credit  Facility  is  reduced  by the  amount of any  equity
financing  we  obtain  after  the  May 26,  2004  effective  date of the  second
amendment and through the December 31, 2004 commitment period,  exclusive of the
proceeds from the May 2004 Private  Placement.  Accordingly,  the commitment has
been  reduced to  approximately  $3.6  million as a result of the closing of the
July 2004 PIPE.  At October 22, 2004,  the Company has issued no Notes under the
Marr Credit  Facility.  As  consideration  for the  extension of the  commitment
period reflected in the second amendment of the Marr Credit Facility,  we issued
to Marr a warrant to purchase  500,000 shares of our Common Stock at an exercise
price of $0.40 per share.  This warrant is immediately  exercisable  and expires
two years from its date of  issuance,  on May 26,  2006.  The shares  underlying
these three warrants were included in our June 15, 2004 registration statement.

SUMMARY OF SHARE ISSUANCES AND POTENTIAL ISSUANCES

In  addition  to the shares  previously  issued,  as noted in the  tables  above
summarizing the Company's recent financings and other transactions,  the Company
may be required  to issue  additional  shares  upon the  exercise of warrants or
options relating to its financings,  contracts for services with consultants, or
pursuant to its employee  benefit  plans or other  agreements.  To summarize the
above,  from 2002  through  October  22, 2004  Calypte has issued  shares of its
Common  Stock  as  follows  and  projects  the  following  potential  additional
issuances  of  shares of its  authorized  common  stock,  most of which has been
registered.



                                                                                                      SHARES POTENTIALLY
                                SHARE USAGE                                          SHARES ISSUED    ISSUABLE
- -------------------------------------------------------------------------            --------------   ------------------
                                                                                                
Shares outstanding at January 1, 2002                                                   1.3 million          0.1 million
Shares issued pursuant to Recent Financing arrangements                               143.1 million         11.6 million
Shares issued pursuant to warrants, options and stock grants to obtain
  services and licenses
                                                                                       20.4 million          0.7 million
Shares issued pursuant to License Agreement with Ani Biotech                            1.2 million          3.0 million
Shares issued pursuant to employee and director option plans and employee
  stock purchase plan
                                                                                        2.0 million         40.4 million
Other general business purposes                                                         1.3 million                   --
                                                                                     --------------   ------------------
      Shares outstanding at October 22, 2004                                          169.3 million         55.8 million
                                                                                     ==============   ==================


      Although management believes that our current financing  arrangements will
be adequate to sustain our  operations  at expected  levels  through 2004 in the
absence of any  unanticipated  material costs and expenses that are not factored
into our cash flow projections,  we expect that we will need to raise additional
capital to sustain our  operations  and achieve our business  milestones in 2005
and  thereafter.  We are  requesting  stockholder  approval of this  Proposal to
authorize  additional  equity  financing  of  up to  $16.5  million.  We do  not
currently have any  agreements in place with respect to a prospective  financing
and we will  continue to seek such  financing  on terms that are  negotiated  in
arms-length transactions. We expect, however, based on current market prices for
our Common Stock,  that the need to raise  additional  funds through the sale of
equity will result in the issuance of a  significant  number of shares of Common
Stock and/or attached warrants. The contemplated  prospective  financing,  if at
less than $0.40 per share of Common  Stock,  would also  require the issuance of
additional  shares  and both  additional  and  re-priced  warrants  to  previous
investors  under the terms of  anti-dilution  protection  provisions in previous
financing  arrangements.  These  issuances  will have a  dilutive  effect on the
interest of current stockholders.


                                       17


      In the past,  Calypte has raised  money  through the sale of shares of its
common stock at a discount to the current market price.  Such  arrangements have
included  the private  sale of shares to  investors  on the  condition  that the
Company  register such shares for resale by the  investors to the public.  These
arrangements  have taken various forms  including  private  placements  commonly
known as PIPE transactions,  equity lines of credit and convertible  debentures.
At the  present  time,  the  Company  intends to use the  proceeds  from  future
offerings or financings,  including any prospective financing for which approval
is requested in this Proposal for general working  capital  purposes as we build
distribution and execute on our plan to generate revenues from our rapid HIV-1/2
products under development and/or currently being commercialized.

      The Company expects that its future financing  arrangements could include:
(i) PIPE Transactions; (ii) equity lines; (iii) convertible debentures; and (iv)
bank  or  institutional  financings,  if  qualified  in the  future.  Due to our
continuing  need to conserve our cash resources,  Calypte  continues to look for
ways to minimize the use of cash while obtaining required services. Accordingly,
we may continue to issue options, warrants, or stock grants in consideration for
additional  services,  and we may issue these options and warrants in return for
services at discounts to market.

APPROVAL REQUIRED

      Approval of this Proposal  requires the affirmative  vote of a majority of
the outstanding  shares of Common Stock of the Company  represented in person or
by proxy and voting at the Special Meeting.

      If the  stockholders do not approve this proposal,  the Company may not be
able to arrange the financing necessary to sustain its current operations beyond
2004 and/or it may have to withdraw its listing on the American Stock Exchange.

      THE  BOARD  UNANIMOUSLY  RECOMMENDS  A VOTE  FOR  THE  AUTHORIZATION  OF A
FINANCING  OF UP TO $16.5  MILLION.  PROXIES  SOLICITED  BY THE BOARD WILL BE SO
VOTED UNLESS STOCKHOLDERS SPECIFY A DIFFERENT CHOICE IN THEIR PROXIES.


                                       18


                             STOCK PERFORMANCE CHART

      The graph below compares the cumulative  total  stockholder  return on the
Common  Stock  assuming  an  initial   investment  on  December  31,  1998.  The
Corporation's  return is shown with the  cumulative  total  return of the NASDAQ
Stock Market--U.S. Index and the Nasdaq Biotechnology Index. The graph assumes a
$100 investment made at the beginning of the respective  period and reinvestment
of all dividends.

                  COMPARISON OF 5 YEAR CUMULATIVE TOTAL RETURN*
      AMONG CALYPTE BIOMEDICAL CORPORATION, THE NASDAQ STOCK MARKET (U.S.)
                                     INDEX
                       AND THE NASDAQ BIOTECHNOLOGY INDEX

  [THE FOLLOWING TABLE WAS DEPICTED AS A LINE CHART IN THE PRINTED MATERIAL.]



                                                      Cumulative Total Return
                                    -------------------------------------------------------------
                                     12/98      12/99      12/00      12/01      12/02      12/03
                                                                         
CALYPTE BIOMEDICAL CORPORATION      100.00      48.90      36.42       6.43       1.88       0.54
NASDAQ STOCK MARKET (U.S.)          100.00     186.20     126.78      96.96      68.65     108.18
NASDAQ BIOTECHNOLOGY                100.00     226.87     291.54     245.15     150.17     220.05


* $100  invested  on  12/31/98  in  stock  or  index-including  reinvestment  of
dividends. Fiscal year ending December 31.


                                       19


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

      Except as set forth in the footnotes to this table,  the  following  table
sets forth  information  known to the  Company  with  respect to the  beneficial
ownership of its Common  Stock as of October 22, 2004 for (i) all persons  known
by the Company to own beneficially more than 5% of its outstanding Common Stock,
(ii) each of the Company's  directors,  (iii) each Named  Executive  Officer and
(iv) all directors and executive officers of the Company as a group.



                                                                        SHARES
                                                                     BENEFICIALLY       % OF
5% STOCKHOLDERS, DIRECTORS AND OFFICERS(1)                               OWNED        TOTAL(2)
- ------------------------------------------                           ------------    ----------
                                                                               

Marr Technologies BV (3)                                               49,540,151         28.73
    Strawinskylaan 1431
    1077XX, Amsterdam
    The Netherlands
SF Capital Partners Ltd. (4)                                           10,322,000          6.10
    3600 South Lake Drive
    St. Francis, WI 53235
Anthony J. Cataldo (5)                                                  5,022,341          2.88
J. Richard George (6)                                                   2,555,717          1.49
Richard D. Brounstein  (7)                                              1,507,371             *
John DiPietro (8)                                                         307,977             *
Paul Freiman (9)                                                          309,901             *
Julius Krevans, M.D.(10)                                                  308,468             *
Maxim A. Soulimov (11)                                                    200,000             *

All current directors and executive officers as a group (7 persons)    10,211,775          5.70


- ----------
*     Represents beneficial ownership of less than 1%.

(1)   To the Company's  knowledge,  except as set forth in the footnotes to this
      table and subject to applicable community property laws, each person named
      in this table has sole  voting and  investment  power with  respect to the
      shares  set  forth  opposite  such  person's  name.  Except  as  otherwise
      indicated, the address of each of the persons in this table is as follows:
      c/o  Calypte  Biomedical  Corporation,   5000  Hopyard  Road,  Suite  480,
      Pleasanton, California 94588.

(2)   Based on 169,321,669 shares outstanding as of October 22, 2004.

(3)   As reported in Amendment  No. 4 to Schedule 13D dated August 9, 2004 filed
      with the Securities and Exchange  Commission.  Includes  3,125,000  shares
      subject to warrants exercisable within 60 days. Marat Safin has voting and
      investment control over shares held by Marr Technologies BV.

(4)   As reported in Schedule  13G dated June 3, 2004 filed with the  Securities
      and Exchange  Commission.  Excludes  3,500,000  shares subject to warrants
      held by SF Capital  Partners  Ltd. Such warrants are subject to conversion
      caps that preclude SF Capital  Partners  Ltd. from  utilizing its exercise
      rights  within  60  days to the  extent  that it  would  beneficially  own
      (determined  in  accordance  with Section 13(d) of the  Securities  Act of
      1934) in excess of 4.999% of the Company's common stock,  giving effect to
      such exercise. Michael A. Roth and Brian J. Stark are the founding members
      and direct the  management  of Staro  Asset  Management,  LLC, a Wisconsin
      limited liability company ("Staro"),  which acts as investment manager and
      has sole  power to direct  the  management  of SF  Capital  Partners  Ltd.
      Through Staro,  Messrs. Roth and Stark possess sole voting and dispositive
      power over all of the shares owned by SF Capital Partners Ltd.

(5)   Includes 4,765,556 shares subject to options exercisable within 60 days

(6)   Includes 2,555,717 shares subject to options exercisable within 60 days.

(7)   Includes 1,507,371 shares subject to options exercisable within 60 days.


                                       20


(8)   Includes 307,734 shares subject to options exercisable within 60 days.

(9)   Includes 309,901 shares subject to options exercisable within 60 days.

(10)  Includes 308,001 shares subject to options exercisable within 60 days.

(11)  Includes  200,000  shares subject to options  exercisable  within 60 days.
      Marr  Technologies BV ("Marr"),  the beneficial owner of 49,540,151 shares
      of Calypte  Common stock (the "Marr  Holdings")  has the right to nominate
      two (2)  candidates  to  serve on the  Calypte  Board  of  Directors.  Mr.
      Soulimov was nominated by Marr and subsequently appointed as a director on
      April 2, 2004 upon  approval of the  Calypte  Board of  Directors.  He was
      re-elected as a Director at the annual Meeting of Stockholders on June 22,
      2004. Mr. Soulimov disclaims any direct or indirect  beneficial  ownership
      of Marr  Holdings  and does not exercise any control nor does he take part
      in any investment  decisions undertaken by Marr and does not have a direct
      or indirect pecuniary interest in Marr Holdings.

COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT

      Section 16(a) of the Exchange Act ("Section 16(a)") requires the Company's
executive  officers,  directors,  and  persons  who  own  more  than  10% of the
Company's Common Stock  (collectively,  "Reporting  Persons") to file reports of
ownership  on Form 3 and  changes  in  ownership  on  Form 4 or Form 5 with  the
Commission.  Such  Reporting  Persons are also  required by the  Securities  and
Exchange  Commission  rules to furnish  the  Company  with copies of all Section
16(a) forms that they file.  The Company  believes that during fiscal year 2003,
all the Reporting Persons complied with all applicable filing requirements.

            The remainder of this page is intentionally left blank.


                                       21


                                 OTHER MATTERS

DEADLINE FOR RECEIPT OF  STOCKHOLDER  PROPOSALS  FOR  INCLUSION IN THE COMPANY'S
PROXY STATEMENT FOR THE 2005 ANNUAL MEETING

      Under the rules of the  Securities  and Exchange  Commission,  stockholder
proposals  submitted  for next year's  Proxy  Statement  must be received by the
Company  no later  than  the  close of  business  on  February  7,  2005,  to be
considered.  Proposals should be addressed to Jerrold Dotson, Secretary, Calypte
Biomedical Corporation, 5000 Hopyard Road, Suite 480, Pleasanton, CA 94588.

      Any  stockholder  who  wishes  to  bring a  proposal  before  the  Calypte
Biomedical Corporation 2005 Annual Meeting of Stockholders, but does not wish to
include it in the Company's proxy materials,  must provide written notice of the
proposal to Calypte's Secretary, at the above address, by March 10, 2005.

OTHER INFORMATION

      The Company does not know of any matters  other than those  referred to in
the  accompanying  Notice of Special Meeting of  Stockholders  that may properly
come before the meeting or other matters incident to the conduct of the meeting.
As to any other matter or proposal  that may  properly  come before the meeting,
including voting on a proposal omitted from this Proxy Statement pursuant to the
rules of the  Securities  and Exchange  Commission,  it is intended that proxies
received will be voted in accordance with the discretion of the proxy holders.

      There are no matters on the agenda that  involve  rights of appraisal of a
stockholder.  The  Company  incorporates  by  reference  all items  and  matters
contained  in its Form  10-KSB for the Fiscal  Year ended  December  31, 2003 as
filed with the  Securities  and  Exchange  Commission  in  addition  to its Form
10-QSBs and Form 8-K Reports as filed with the Commission.

                                          By order of the Board of Directors,


                                          /s/ J. Richard George
                                          --------------------------------------
                                          J. Richard George
                                          President and Chief Executive Officer

Pleasanton, California
November __, 2004


                                       22


                         CALYPTE BIOMEDICAL CORPORATION
                          5000 HOPYARD ROAD, SUITE 480
                          PLEASANTON, CALIFORNIA 94588

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned hereby appoints J. RICHARD GEORGE and RICHARD D. BROUNSTEIN, and
each of them,  with full power of  substitution,  as the proxy or proxies of the
undersigned to vote all shares of Common Stock of Calypte Biomedical Corporation
which the undersigned is entitled to vote at the special meeting of stockholders
of Calypte  Biomedical  Corporation to be held at the Company's  offices at 5000
Hopyard Road, Suite 480,  Pleasanton,  California 94588 on December 14, 2004, at
10:00 a.m. local time, and at any  adjournments or postponements  thereof,  with
all powers that the undersigned would have if personally present thereat:

                            (CONTINUED ON OTHER SIDE)

                          /*\ FOLD AND DETACH HERE /*\
================================================================================

PLEASE MARK       [X]
YOUR VOTES
AS THIS

This proxy, when properly executed,  will be voted in the manner directed herein
by the  undersigned  stockholder.  If no direction  is made,  this proxy will be
voted FOR the Proposal.




                                                                                                  
1.    Proposal to  authorize  the  Company's  Board of Directors to enter into a    FOR        AGAINST     ABSTAIN
      financing  transaction  to raise up to $16.5  million by the  issuance  of    [_]          [_]         [_]
      Common  Stock or  equivalents  and/or the issuance of warrants to purchase
      shares  of  Common  Stock  within  90 days  from the date of  the  Special
      Meeting  on  terms  and   conditions   that  may  result  in  dilution  to
      stockholders and may trigger certain anti-dilution protections provided to
      certain existing stockholders. Stockholder approval of the within proposal
      is required for the Company to maintain its listing on the American  Stock
      Exchange  in the event that it issues  shares of Common  Stock or warrants
      that results in the issuance in excess of 20% of its currently  issued and
      outstanding  Common Stock or if the anti-dilution  provisions  provided to
      certain stockholders are triggered.

      (The Board of Directors recommends a vote FOR.)


In their discretion, the proxies are authorized to vote upon such other business
as may properly come before the meeting and at any  adjournment or  postponement
thereof.

      PLEASE  MARK,  SIGN,  DATE AND RETURN THE PROXY  CARD  PROMPTLY  USING THE
ENCLOSED  ENVELOPE.

Signature   of   Stockholder____________________   Signature   if  held  jointly
___________________ Dated: ________, 2004

Please  sign  exactly  as name  appears  above.  When  shares  are held by joint
tenants,  both should sign. When signing as attorney,  executor,  administrator,
trustee or guardian,  please give full title as such. If a  corporation,  please
sign in full corporate name by President or other authorized person.