UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                 AMENDMENT NO. 1
                                       TO
                                    FORM 8-K

                                 CURRENT REPORT
     PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934


       Date of Report (Date of Earliest Event Reported): November 12, 2004



                              PHARMAFRONTIERS CORP.
                              ---------------------
             (Exact name of registrant as specified in its charter)



                                      TEXAS
                                      -----
                 (State or other jurisdiction of incorporation)



                000-25513                                   760333165
                ---------                                   ---------
       (Commission File Number)             (I.R.S. Employer Identification No.)



                835 Greens Parkway, Suite 150, Houston, TX 77067
                ------------------------------------------------
          (Address of principal executive offices, including zip code)




                                 (281) 272-9331
                                 --------------
              (Registrant's telephone number, including area code)






EXPLANATORY NOTE:

PharmaFrontiers Corp., a Texas corporation (the "Company") is filing this
Current Report on Form 8-K/A in order to amend its Current Report on Form 8-K,
filed on October 8, 2004, and incorporated herein by reference, regarding the
acquisition of multiple sclerosis cell therapy developer Opexa Pharmaceuticals,
Inc., as reported in the Company's Current Report filed on Form 8-K filed on
November 8, 2004, and incorporated herein by reference, to provide certain
financial disclosures required by Item 9.01 with respect to such acquisition as
follows:

This Amendment does not reflect events occurring after the filing of the October
8, 2004 Form 8-K, nor does it modify or update those disclosures in any way.

ITEM 9.01. FINANCIAL STATEMENTS AND EXHIBITS

(A)   FINANCIAL STATEMENTS OF BUSINESSES ACQUIRED.

The following financial statements of Opexa Pharmaceuticals, Inc. and
accompanying explanatory notes are being filed as Exhibits and incorporated
herein by reference:

(i)   Report of Independent Auditors for the fiscal year ended December 31,
      2003;

(ii)  Report of Independent Auditors for the fiscal year ended December 31,
      2002;

(iii) Audited balance sheet as of December 31, 2003;

(iv)  Audited statements of expenses for the years ended December 31, 2003 and
      December 31, 2002 and the period from February 16, 2001 (inception)
      through December 31, 2003;

(v)   Audited statement of changes in stockholders' deficit the period from
      February 16, 2001 (inception) through December 31, 2003;

(vi)  Audited statements of cash flows for the years ended December 31, 2003 and
      December 31, 2002 and the period from February 16, 2001 (inception)
      through December 31, 2003;

(vii) Notes to audited financial statements.

(viii) Unaudited balance sheet as of June 30, 2004;

(ix)  Unaudited statements of expenses for the three and six months ended June
      30, 2004 and June 30, 2003 and the period from February 16, 2001
      (inception) through June 30, 2004;

(x)   Unaudited statements of cash flows for the six months ended June 30, 2004
      and June 30, 2003 and the period from February 16, 2001 (inception)
      through June 30, 2004;

(xi)  Notes to unaudited financial statements.


(B)   PRO FORMA FINANCIAL INFORMATION

The following pro forma financial information is being filed with this Current
Report:

(i)   Unaudited pro forma consolidated condensed balance sheet as of December
      31, 2003;

(ii)  Unaudited pro forma consolidated condensed income statement for the year
      ended December 31, 2003;

(iii) Unaudited pro forma consolidated condensed balance sheet for the six
      months ended June 30, 2004;

(iv)  Unaudited pro forma consolidated condensed income statement for the six
      months ended June 30, 2004;

(v)   Notes to unaudited pro forma consolidated condensed financial statements.




(C)   EXHIBITS.

2.1   Agreement and Plan of Reorganization among PharmaFrontiers Corp., Pharma
      Acquisition Corp., and Opexa Pharmaceuticals, Inc. dated as of October 7,
      2004, incorporated herein by reference to the Company's Current Report on
      Form 8-K filed on November 8, 2004.

99.1  Report of Independent Auditors for the fiscal year ended December 31,
      2003;

      Report of Independent Auditors for the fiscal year ended December 31,
      2002;

      Audited balance sheet as of December 31, 2003;

      Audited statements of expenses for the years ended December 31, 2003 and
      December 31, 2002 and the period from February 16, 2001 (inception)
      through December 31, 2003;

      Audited statement of changes in stockholders' deficit the period from
      February 16, 2001 (inception) through December 31, 2003;

      Audited statements of cash flows for the years ended December 31, 2003 and
      December 31, 2002 and the period from February 16, 2001 (inception)
      through December 31, 2003;

      Notes to audited financial statements.

99.2  Unaudited balance sheet as of June 30, 2004;

      Unaudited statements of expenses for the three and six months ended June
      30, 2004 and June 30, 2003 and the period from February 16, 2001
      (inception) through June 30, 2004;

      Unaudited statements of cash flows for the six months ended June 30, 2004
      and June 30, 2003 and the period from February 16, 2001 (inception)
      through June 30, 2004;

      Notes to unaudited financial statements.

99.3  Unaudited pro forma consolidated condensed balance sheet as of December
      31, 2003;

      Unaudited pro forma consolidated condensed income statement for the year
      ended December 31, 2003;

      Unaudited pro forma consolidated condensed balance sheet for the six
      months ended June 30, 2004;

      Unaudited pro forma consolidated condensed income statement for the six
      months ended June 30, 2004;

      Notes to unaudited pro forma consolidated condensed financial statements.




                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.



                                     PHARMAFRONTIERS CORP.



                                     By:  /s/ David McWilliams
                                     -------------------------
                                     David McWilliams, Chief Executive Officer

DATE:  November 12, 2004




                                  EXHIBIT INDEX


The following exhibits are to be filed as part of this 8-K:

 EXHIBIT NO.       IDENTIFICATION OF EXHIBIT
 ----------        -------------------------

2.1                 Agreement and Plan of Reorganization among PharmaFrontiers
                    Corp., Pharma Acquisition Corp., and Opexa Pharmaceuticals,
                    Inc. dated as of October 7, 2004, incorporated herein by
                    reference to the Company's Current Report on Form 8-K filed
                    on November 8, 2004.

99.1                Report of Independent Auditors for the fiscal year ended
                    December 31, 2003;

                    Report of Independent Auditors for the fiscal year ended
                    December 31, 2002;

                    Audited balance sheet as of December 31, 2003;

                    Audited statements of expenses for the years ended December
                    31, 2003 and December 31, 2002 and the period from February
                    16, 2001 (inception) through December 31, 2003;

                    Audited statement of changes in stockholders' deficit the
                    period from February 16, 2001 (inception) through December
                    31, 2003;

                    Audited statements of cash flows for the years ended
                    December 31, 2003 and December 31, 2002 and the period from
                    February 16, 2001 (inception) through December 31, 2003;

                    Notes to audited financial statements.

99.2                Unaudited balance sheet as of June 30, 2004;

                    Unaudited statements of expenses for the three and six
                    months ended June 30, 2004 and June 30, 2003 and the period
                    from February 16, 2001 (inception) through June 30, 2004;

                    Unaudited statements of cash flows for the six months ended
                    June 30, 2004 and June 30, 2003 and the period from February
                    16, 2001 (inception) through June 30, 2004;

                    Notes to unaudited financial statements.

99.3                Unaudited pro forma consolidated condensed balance sheet as
                    of December 31, 2003;

                    Unaudited pro forma consolidated condensed income statement
                    for the year ended December 31, 2003;

                    Unaudited pro forma consolidated condensed balance sheet for
                    the six months ended June 30, 2004;

                    Unaudited pro forma consolidated condensed income statement
                    for the six months ended June 30, 2004;

                    Notes to unaudited pro forma consolidated condensed
                    financial statements.