EXHIBIT 32.1

                                  CERTIFICATION
                                       OF
               CHIEF EXECUTIVE OFFICER AND CHIEF FINANCIAL OFFICER

      Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of
the Sarbanes-Oxley Act of 2002, each of the undersigned officers of Manhattan
Pharmaceuticals, Inc. do hereby certify that:

            (a) the Quarterly Report on Form 10-QSB of Manhattan
Pharmaceuticals, Inc. for the quarter ended September 30, 2003 (the "Report:)
fully complies with the requirements of Section 13(a) or 15(d) of the Securities
Exchange Act of 1934; and

            (b) information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of
Manhattan Pharmaceuticals, Inc.


Dated: November 15, 2004     /s/ Leonard Firestone
                             ---------------------------------------------------
                             Leonard Firestone
                             President and Chief Executive Officer


Dated: November 15, 2004     /s/ Nicholas J. Rossettos
                             ---------------------------------------------------
                             Nicholas J. Rossettos
                             Chief Financial Officer and Chief Operating Officer