EXHIBIT 10.3

                          REGISTRATION RIGHTS AGREEMENT

      REGISTRATION RIGHTS AGREEMENT (the "Agreement"), dated as of December ___,
2004, is entered into by and among ENHANCE BIOTECH, INC., a Delaware corporation
("Parent"),  ARDENT ACQUISITION  CORP., a North Carolina  corporation and wholly
owned  subsidiary of Parent ("Merger Sub") and ARDENT  PHARMACEUTICALS,  INC., a
North Carolina corporation ("Ardent").


                              W I T N E S S E T H:

            WHEREAS,  Parent,  Merger  Sub and  Ardent  have  entered  into that
certain  Merger  Agreement  dated August 11, 2004, as amended as of November 20,
2004  (the  "Merger  Agreement"),  pursuant  to which  Parent  and  Ardent  have
consummated  a business  combination  whereby  Merger  Sub merged  with and into
Ardent and each  outstanding  security of Ardent was converted into the right to
receive the Merger Consideration;

            WHEREAS, in connection with the conversion of Ardent securities into
the Merger  Consideration,  Parent has  agreed to provide  certain  registration
rights pursuant to the terms of this Agreement;

            NOW,  THEREFORE,  in  consideration  of  the  mutual  covenants  and
obligations  hereinafter set forth, the parties hereto,  intending to be legally
bound, hereby agree as follows:

      1.  Definitions.  Capitalized  terms used and not otherwise defined herein
that are defined in the Merger Agreement shall have the meaning ascribed to such
terms in the Merger  Agreement.  As used in this  Agreement the following  terms
shall have the following meanings:

            1.1 "Commission"  shall mean the Securities and Exchange  Commission
or any other federal agency at the time administering the Securities Act.

            1.2 "Common Stock" shall mean shares of Parent's  common stock,  par
value $0.001 per share.

            1.3 "Exchange Act" shall mean the  Securities  Exchange Act of 1934,
as amended, or any similar federal statute enacted hereafter,  and the rules and
regulations  of the  Commission  thereunder,  all as the same shall be in effect
from time to time.

            1.4  "Filing  Date"  shall mean the date which is the earlier of the
following:  (x)  as  soon  as  practicable  after  consummation  of a  Qualified
Financing;  or (y) the date which is not more than the 150th day  following  the
Effective Date of the Merger.



            1.5 "Form  SB-2"  means  such form  under the  Securities  Act as in
effect on the date  hereof or any  registration  form under the  Securities  Act
subsequently  adopted by the Commission which permits inclusion or incorporation
of substantial  information by reference to other documents filed by Parent with
the Commission.

            1.6  "Holder"  shall  mean any  security  holder  of  Ardent to whom
Registrable Securities are issued pursuant to the Merger Agreement.

            1.7  "Person"  shall  mean  any   individual,   firm,   corporation,
partnership,  trust, incorporated or unincorporated association,  joint venture,
joint stock company,  government (or an agency or political subdivision thereof)
or other entity of any kind.

            1.8  "Prospectus"   shall  mean  the  prospectus   included  in  the
Registration Statement, as amended or supplemented by any prospectus supplement,
with  respect to the terms of the  offering  of any  portion of the  Registrable
Securities covered by the Registration  Statement,  and all other amendments and
supplements to the  Prospectus,  including  post-effective  amendments,  and all
material  incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

            1.9 "Qualified  Financing" means an equity financing by Parent of at
least $10,000,000 with a minimum valuation of at least $1.50 per share of Common
Stock.

            1.10 "Registration  Statement" shall mean the registration statement
required  to be  filed  hereunder,  including  the  Prospectus,  amendments  and
supplements to such  registration  statement or  Prospectus,  including pre- and
post-effective  amendments,  all exhibits thereto, and all material incorporated
by reference  or deemed to be  incorporated  by  reference in such  registration
statement.

            1.11  "Registrable  Securities"  shall mean for each  Holder,  up to
30,000  shares of Common  Stock  issued to such  Holder  pursuant  to the Merger
Agreement at the Effective Time;  provided,  however,  that the shares of Common
Stock  reserved  pursuant to the Merger  Agreement for issuance upon exercise or
conversion of Ardent stock options,  warrants and convertible  promissory  notes
shall not be deemed "Registrable  Securities" if such stock options and warrants
were not  exercised  prior to or at the  Effective  Time or if such  convertible
promissory notes were not converted prior to or at the Effective Time; provided,
however, that the term "Registrable Securities" shall not include (i) any shares
of Common Stock that have been  registered and sold pursuant to a  registration,
or (ii) any shares of Common  Stock  that have been sold,  or could then be sold
within any three (3) month period,  pursuant to Rule 144  promulgated  under the
Securities Act.

            1.12  "Registration  Expenses"  shall mean all of Parent's  expenses
relating to Parent's compliance with Sections 2 and 3 hereof, including, without
limitation,  all SEC and "blue  sky"  registration  and  filing  fees,  printing
expenses, fees for listing on any national exchange on which Parent may list the
Registrable  Shares,  any transfer taxes  applicable to the initial  issuance of
Registrable  Securities  to  each  Holder,  fees  of  any  transfer  agents  and
registrars,  fees and  disbursements of Parent's counsel and independent  public
accountants for

                                      -19-


Parent,  including  expenses  incurred by Parent in connection  with any special
audits incidental to or required by such  registration.  The term  "Registration
Expenses"  shall  not  include  any  of  the  following,   which  are  sometimes
hereinafter  referred to as "Individual  Holder  Expenses":  underwriting  fees,
discounts  and  expenses,   if  any,  applicable  to  any  Holder's  Registrable
Securities;  fees and disbursements of counsel or other  professionals  that any
Holder may choose to retain in connection with the registration  statement filed
pursuant  to  this  Agreement;  selling  commissions  or  stock  transfer  taxes
applicable to the Registrable Securities registered on behalf of any Holder; any
other  expenses  incurred by or on behalf of such Holder in connection  with the
offer and sale of such Holder's  Registrable  Securities other than Registration
Expenses.

            1.13  "Securities  Act" shall mean the  Securities  Act of 1933,  as
amended,  or any similar federal statute  enacted  hereafter,  and the rules and
regulations  of the  Commission  thereunder,  all as the same shall be in effect
from time to time.

      2. Registration.  On or prior to the Filing Date, Parent shall prepare and
file with the Commission a registration statement on Form SB-2 (or, if such form
is unavailable  for such a  registration,  on such other form as is available to
Parent for such a  registration),  covering the resale of all of the Registrable
Securities.  Parent shall use its commercially  reasonable best efforts to cause
the Registration  Statement to be declared effective under the Securities Act as
promptly as  practicable  on or after the 180th day following the Effective Date
of the Merger. Parent shall use its commercially reasonable best efforts to keep
the  Registration  Statement  continuously  effective  under the  Securities Act
during  the  period  from the  Effective  Date of the  Merger  until  the  first
anniversary of the Effective Date of the Merger (the "Effective Period").

      3. Registration Procedures; Condition to Parent's Obligations.

            3.1  Parent  will keep each  Holder  advised  in  writing  as to the
initiation of the  Registration  Statement and as to the completion  thereof and
will, at its expense:

                  (a) use its commercially  reasonable best efforts to keep such
registration effective for the Effective Period;

                  (b) Prepare and file with the Commission  such  amendments and
supplements to the Registration Statement and the Prospectus as may be necessary
to  comply  with  the  provisions  of the  Securities  Act with  respect  to the
disposition of all securities covered by such Registration Statement;

                  (c) Furnish such number of  Prospectuses  and other  documents
incident thereto, including any amendment of or supplement to the Prospectus, as
a Holder from time to time may  reasonably  request,  but only while the Company
shall  be  required  under  the  provisions  hereof  to cause  the  registration
statement to remain current;

                  (d) Notify each Holder of  Registrable  Securities  covered by
the  Registration  Statement at any time when a Prospectus  relating  thereto is
required to be delivered  under the Securities Act of the happening of any event
as a result of which the Prospectus included in such Registration  Statement, as
then in effect,  includes  an untrue  statement  of a material  fact or omits to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein  not  misleading  in the  light  of the  circumstances  then
existing,  and at the  request of any such  Holder,  prepare and furnish to such
Holder a reasonable  number of copies of a supplement to or an amendment of such
Prospectus  as  may  be  necessary  so  that,  as  thereafter  delivered  to the
purchasers of such shares, such Prospectus shall not include an untrue statement
of a  material  fact or omit to state a  material  fact  required  to be  stated
therein or necessary to make the statements  therein not misleading in the light
of the circumstances then existing;

                                      -20-


                  (e) Use its best efforts to cause all  Registrable  Securities
covered by such Registration Statement to be registered with or approved by such
other federal or state governmental  agencies or authorities as may be necessary
in the opinion of counsel to Parent and  counsel to the  Holders of  Registrable
Securities to enable the Holders  thereof to consummate the  disposition of such
Registrable Securities (provided, however, that Parent shall not be obligated to
qualify  as a  foreign  corporation  to  do  business  under  the  laws  of  any
jurisdiction  in  which  it is  not  then  qualified),  and  maintain  any  such
registration  or  qualification  current  until the  earlier  of the sale of the
Registrable  Securities so  registered or until the  expiration of the Effective
Period;

                  (f) List all such  Registrable  Securities  registered in such
registration on each securities  exchange or automated quotation system on which
the Common Stock of Parent is then listed;

                  (g) Provide a transfer agent and registrar for all Registrable
Securities and a CUSIP number for all such Registrable Securities,  in each case
not later than the effective date of such registration;

                  (h) Prior to filing the  registration  statement  covering the
Registrable  Securities,  make  available for  inspection at Parent's  corporate
office  in  New  York,  New  York  upon  reasonable  request  by any  Holder  of
Registrable Securities, any attorney,  accountant or other agent retained by any
of the Holders,  during normal business hours of Parent and without unreasonable
disruption of Parent's business or unreasonable expense to Parent and solely for
the purpose of due diligence  with respect to the  registration  statement,  all
publicly  available,  non-confidential  financial and other  records,  including
without limitation  pertinent  corporate documents of Parent, and cause Parent's
officers,  directors and employees to supply, at the requesting  parties expense
and without unreasonable disruption of Parent's business or unreasonable expense
to parent and  solely  for the  purpose  of due  diligence  with  respect to the
registration  statement,  all publicly available,  non-confidential  information
reasonably  requested by the  attorney,  accountant or other agent of any of the
Holders;

            3.2 It shall be a condition  precedent to the  obligations of Parent
to take any action  pursuant to this  Agreement  that each of the Holders  whose
Registrable  Securities are to be registered  pursuant to this  Agreement  shall
furnish  the  following  to  Parent  prior  to  performance  by  Parent  of  its
obligations under this Agreement:

                  (a) written evidence reasonably satisfactory to Parent of each
such Holder's agreement to be bound by this Agreement;

                                      -21-


                  (b)  information  regarding each such Holder,  the Registrable
Securities held by such Holder,  and any additional  information as Parent shall
reasonably  request and as shall be required in connection with the action to be
taken by Parent;

                  (c) written evidence reasonably satisfactory to Parent of each
such  Holder's  agreement  to provide  customary  indemnifications  to Parent in
respect of information furnished by or on behalf of each Holder or actions taken
or omitted by each Holder (as consistent with the indemnification  provisions of
this  Agreement),  and to pay the Individual  Holder Expenses  incurred by or on
behalf of each Holder which are not Registration Expenses required to be paid by
Parent  hereunder,  and to customary  blackout  periods in the event of material
corporate developments affecting Parent or its securities; and

                  (d) written evidence reasonably satisfactory to Parent of each
Holder's  agreement  that  upon  receipt  of any  written  notice  by  Parent to
discontinue  use of the  registration  statement  or any  prospectus  or related
document until the same are supplemented or amended, that Holder will so refrain
and,  if so directed by Parent,  will  deliver to Parent all copies,  other than
permanent file copies, then in Holder's possession of such documents at the time
of receipt of such  notice.  Furthermore,  each Holder  shall agree that if such
Holder uses a prospectus in connection  with the offering and sale of any of the
Registrable  Securities,  the Holder  will use only the  latest  version of such
prospectus provided by Parent.

      4. Expenses.  All  Registration  Expenses  incurred in connection with any
registration,  qualification or compliance  pursuant to Sections 2 and 3 of this
Agreement shall be borne by Parent.

      5. Indemnification.

            5.1  Indemnification by Parent. To the full extent permitted by law,
Parent  will  indemnify  each  Holder,  each  of  its  officers,  directors  and
employees,  and each  person  controlling  a Holder  within  the  meaning of the
Securities Act, with respect to which registration,  qualification or compliance
has been effected pursuant to this Agreement against all claims, losses, damages
and  liabilities  (or actions,  proceedings or  settlements in respect  thereof)
arising out of or based on any untrue statement (or alleged untrue statement) of
a material fact contained in any prospectus, offering circular or other document
(including  any  related  registration  statement,  notification  or  the  like)
incident to any such registration,  qualification or compliance, or based on any
omission (or alleged  omission) to state  therein a material fact required to be
stated therein or necessary to make the statements  therein not  misleading,  or
any  violation  by  Parent  of the  Securities  Act or any  rule  or  regulation
thereunder  applicable to Parent and relating to action or inaction  required of
Parent in connection with any such  registration,  qualification  or compliance,
and will  reimburse  each  such  Holder,  each of its  officers,  directors  and
partners,  and each person  controlling  such Holder for any legal and any other
expenses  reasonably  incurred in connection with investigating and defending or
settling any such claim, loss, damage, liability or action, provided that Parent
will not be liable in any such case to the  extent  that any such  claim,  loss,
damage,  liability or expense arises out of or is based on any untrue  statement
or omission made in reliance upon and based upon written  information  furnished
to Parent by or on behalf of such Holder for use therein.

                                      -22-


            5.2 Indemnification by the Holders.  Each Holder will, to the extent
Registrable  Securities  held  by  him or it are  included  in the  Registration
Statement,  indemnify Parent, each of its directors,  officers and employees and
each other  person,  if any,  who  controls  Parent  within  the  meaning of the
Securities Act, against all claims,  losses,  damages,  expenses and liabilities
(or actions in respect  thereof) arising out of or based on any untrue statement
(or  alleged  untrue  statement)  of a  material  fact  contained  in  any  such
Registration Statement,  Prospectus, offering circular or other document, or any
omission (or alleged  omission) to state  therein a material fact required to be
stated therein or necessary to make the statements  therein not  misleading,  or
any  violation by such Holder of the  Securities  Act or any rule or  regulation
thereunder applicable to such Holder and relating to action or inaction required
of such  Holder  in  connection  with any such  registration,  qualification  or
compliance,  and will  reimburse  Parent,  each of its  directors,  officers and
employees and each other person for any legal or any other  expenses  reasonably
incurred in connection  with  investigating  or defending any such claim,  loss,
damage,  liability  or action,  in each case with respect to any such alleged or
actual  untrue  statement  of a material  fact or alleged or actual  omission to
state a material  fact to the extent,  but only to the extent,  that such untrue
statement (or alleged  untrue  statement)  or omission (or alleged  omission) is
made in such  Registration  Statement,  Prospectus,  offering  circular or other
document in reliance upon and in conformity with written  information  furnished
to Parent by such Holder for use therein.

            5.3  Notices of Claims,  Procedures,  etc.  Each party  entitled  to
indemnification under this Section 5 (the "Indemnified Party") shall give notice
to the party  required to provide  indemnification  (the  "Indemnifying  Party")
promptly after such  Indemnified  Party has actual  knowledge of any claim as to
which indemnity may be sought, and shall permit the Indemnifying Party to assume
the defense of any such claim or any litigation  resulting  therefrom,  provided
that the  Indemnified  Party may  participate in such defense at the Indemnified
Party's sole expense,  and provided  further that the failure of any Indemnified
Party to give notice as provided herein shall not relieve the Indemnifying Party
of its  obligations  under this Section 5 unless such failure is  prejudicial to
the   ability   of   Indemnifying   Party  to  defend   such  claim  or  action.
Notwithstanding  the foregoing,  such Indemnified  Party shall have the right to
employ its own counsel in any such litigation, proceeding or other action if (i)
the employment of such counsel has been authorized by the Indemnifying Party, in
its sole and absolute  discretion,  or (ii) the named parties in any such claims
(including any impleaded  parties)  include any such  Indemnified  Party and the
Indemnified Party and the Indemnifying  Party shall have been advised in writing
(in suitable  detail) by counsel to the Indemnified  Party either (A) that there
may be one or more legal defenses  available to such Indemnified Party which are
different from or additional to those  available to the  Indemnifying  Party, or
(B) that there is a conflict of interest by virtue of the Indemnified  Party and
the  Indemnifying  Parties having common  counsel,  in any of which events,  the
reasonable  legal fees and  expenses  of a single  counsel  for all  Indemnified
Parties  with  respect to each such claim,  defense  thereof,  or  counterclaims
thereto shall be borne by  Indemnifying  Party.  No  Indemnifying  Party, in the
defense of any such claim or litigation,  shall, except with the consent of each
Indemnified Party, which consent shall not be unreasonably withheld,  consent to
entry of any judgment or enter into any settlement  which does not include as an
unconditional  term  thereof  the giving by the  claimant or  plaintiff  to such
Indemnified  Party of a release  from all  liability in respect to such claim or
litigation.  Each  Indemnified  Party shall  cooperate to the extent  reasonably
required and furnish such information  regarding itself or the claim in question
as an  Indemnifying  Party may  reasonably  request in  writing  and as shall be
reasonably  required in  connection  with  defense of such claim and  litigation
resulting therefrom.

                                      -23-


            5.4  Contribution.  If the  indemnification  provided  for  in  this
Section  5 shall  for any  reason  be held by a court to be  unenforceable  as a
matter of public policy with respect to an  Indemnified  Party in respect of any
loss,  claim,  damage,  expense or liability,  or any action in respect thereof,
then,  in lieu of the amount paid or payable  under  Section 5.1 or Section 5.2,
the Indemnified  Party and the  Indemnifying  Party under Section 5.1 or Section
5.2 shall  contribute to the aggregate  losses,  claims,  damages,  expenses and
liabilities (including legal or other expenses reasonably incurred in connection
with  investigating  the same),  (a) in such  proportion  as is  appropriate  to
reflect the  relative  fault of the  Indemnified  Party and  Indemnifying  Party
covered by the  registration  statement  which  resulted  in such  loss,  claim,
damage,  expense or liability,  or action or proceeding in respect thereof, with
respect to the  statements  or  omissions  which  resulted in such loss,  claim,
damage,  expense or liability,  or action or proceeding in respect  thereof,  as
well as any other  relevant  equitable  considerations  or (b) if the allocation
provided  by clause  (a)  above is not  permitted  by  applicable  law,  in such
proportion as shall be appropriate to reflect the relative  benefits received by
the Indemnified Party and Indemnifying Party from the offering of the securities
covered by such  registration  statement;  provided,  that for  purposes of this
clause (b), the relative benefits  received by the prospective  sellers shall be
deemed  not to  exceed  the  amount of  proceeds  received  by such  prospective
sellers. No person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution  from any
person who was not guilty of such fraudulent misrepresentation. Such prospective
sellers'  obligations  to contribute as provided in this Section 5.4 are several
in proportion to the relative value of their respective  Registrable  Securities
covered by such  registration  statement and not joint.  In addition,  no person
shall be  obligated  to  contribute  hereunder  any  amounts in payment  for any
settlement of any action or claim effected without such person's consent,  which
consent shall not be unreasonably withheld.

      6. [INTENTIONALLY OMITTED]

      7.  Exchange  Act  Compliance.  While  Parent is subject to the  reporting
requirements of the Exchange Act, Parent shall make commercially reasonable best
efforts to file the reports  required to be filed by it under the Securities Act
and the Exchange  Act and the rules and  regulations  adopted by the  Commission
thereunder,  and to take all actions  reasonably  necessary to enable Holders of
Registrable  Securities to sell such securities  without  registration under the
Securities Act within the limitation of the provisions of (a) Rule 144 under the
Securities  Act,  as such Rule may be amended  from time to time,  (b) Rule 144A
under the  Securities  Act,  as such Rule may be amended  from time to time,  if
applicable  or (c) any similar  rules or  regulations  hereunder  adopted by the
Commission.  Upon the request of any Holder of  Registrable  Securities,  Parent
will  deliver to such holder a written  statement  as to whether it has complied
with such requirements.

      8. Specific Performance.  The parties hereto acknowledge that there may be
no adequate  remedy at law if any party fails to perform any of its  obligations
hereunder and that each party may be irreparably harmed by any such failure, and
accordingly  agree that each party,  in addition to any other remedy to which it
may be  entitled  at law or in  equity,  shall  be  entitled  to seek to  compel
specific  performance of the obligations of any other party under this Agreement
in accordance with the terms and conditions of this Agreement.

                                      -24-


      9. No Registration  Conflict.  Parent has not previously  entered into any
agreement granting any registration rights with respect to any of its securities
to any Person that has not been fully satisfied other than  registration  rights
granted in connection with warrants issued to  Bioaccelerate,  Inc. Parent shall
not after the date hereof enter into any agreement granting  registration rights
with respect to any of its securities outstanding on the date hereof, except (i)
pursuant to the Merger Agreement, (ii) registration rights for Parent's existing
shareholders  who do not have  freely  tradable  shares  on the date  hereof  as
contemplated  by  Section  2.1(j) of the  Merger  Agreement,  or (iii) as may be
determined  by Parent's  Board of Directors  (as  constituted  subsequent to the
Merger) in the exercise of their fiduciary responsibilities.

      10.  Benefits of Agreement;  Successors and Assigns.  This Agreement shall
inure to the benefit of and be binding upon the successors and permitted assigns
of each of the  parties  and shall  inure to the benefit of each Holder and each
Holder  shall be an  intended  third  party  beneficiary  under this  Agreement.
Neither Parent nor any Holder may assign its rights or obligations hereunder.

      11.   Complete   Agreement.   This  Agreement   constitutes  the  complete
understanding  among  the  parties  with  respect  to  its  subject  matter  and
supersedes all existing agreements and understandings,  whether oral or written,
among them. No alteration or  modification  of any  provisions of this Agreement
shall be valid  unless  made in  writing  and  signed,  on the one hand,  by the
Holders of a majority of the Registrable Securities then outstanding and, on the
other, by Parent.

      12. Section Headings. The section headings contained in this Agreement are
for  reference  purposes  only and shall not  affect in any way the  meaning  or
interpretation of this Agreement.

      13. Notices.  All notices,  offers,  acceptances and other  communications
required or  permitted  to be given or to otherwise be made to any party to this
Agreement shall be deemed to be sufficient if contained in a written  instrument
delivered by hand,  first class mail  (registered  or certified,  return receipt
requested),  telex,  telecopier or overnight air courier  guaranteeing  next day
delivery,  if to  Parent,  at 712  Fifth  Avenue,  New York,  New  York,  10019,
Attention:  Andrew J.  Cosentino,  and if to any Holder,  at the address of such
Holder as set forth in the stock transfer books of Parent.  All such notices and
communications shall be deemed to have been duly given: at the time delivered by
hand, if personally  delivered;  five business days after being deposited in the
United  States  mail,  First Class  postage  prepaid,  if mailed;  when  receipt
acknowledged, if telecopied (or on the next succeeding business day if such date
is not a business  day; and the next  business day after timely  delivery to the
courier,  if sent by overnight air courier  guaranteeing next day delivery.  For
purposes of this  paragraph,  a "business day" shall mean any day which is not a
Saturday,  Sunday,  or public  holiday  or a day on which  commercial  banks are
required  or  authorized  by law to close in New York,  New York.  Any party may
change the address to which each such notice or  communication  shall be sent by
giving  written  notice to tie other  parties of such new  address in the manner
provided herein for giving notice.

                                      -25-


      14.  Governing Law. This Agreement shall be governed by, and construed and
enforced in accordance  with,  the laws of the State of Delaware  without giving
effect to the provisions,  policies or principles thereof respecting conflict or
choice of laws.

      15.  Counterparts.   This  Agreement  may  be  executed  in  one  or  more
counterparts  each of which shall be deemed an  original  but all of which taken
together  shall  constitute  one and the same  agreement.  A facsimile copy of a
signature page shall be deemed to be an original signature page.

      16. Severability.  If any term, provision, covenant or restriction of this
Agreement is held by a court of competent  jurisdiction to be invalid,  illegal,
void or  unenforceable,  the remainder of the terms,  provisions,  covenants and
restrictions set forth herein shall remain in full force and effect and shall in
no way be affected,  impaired or  invalidated,  and the parties hereto shall use
their reasonable best efforts to find and employ an alternative means to achieve
the same or  substantially  the same result as that  contemplated  by such term,
provision,  covenant or restriction.  It is hereby stipulated and declared to be
the intention of the parties that they would have executed the remaining  terms,
provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.


                  [Remainder of page intentionally left blank.]



                                      -26-


      IN WITNESS WHEREOF,  the parties have signed this Agreement as of the date
first set forth above.


                                        ENHANCE BIOTECH, INC.

                                        By  /s/  Christopher Every
                                           --------------------------------
                                              Name:  Christopher Every
                                              Title:    President and CEO


                                        ARDENT ACQUISITION CORP.

                                        By  /s/  Christopher Every
                                           --------------------------------
                                              Name:  Christopher Every
                                              Title:    President and CEO


                                        ARDENT PHARMACEUTICALS, INC.

                                        By  /s/  Kwen-Jen Chang
                                           --------------------------------
                                             Name:  Kwen-Jen Chang
                                             Title:    President and CEO