Exhibit 32.1

                            CERTIFICATION PURSUANT TO
                             18 U.S.C SECTION 1350,
                             AS ADOPTED PURSUANT TO
                  SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the Annual Report of OccuLogix, Inc. (the "Company") on
Form 10-K for the year ended  December 31, 2004 as filed with the Securities and
Exchange Commission on the date hereof (the "Report"),  I, Elias Vamvakas,  Jr.,
Chief Executive Officer of the Company,  certify,  pursuant to 18 U.S.C. section
1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that
to the best of my knowledge:

1.    The Report fully complies with the  requirements of section 13(a) or 15(d)
      of the Securities Exchange Act of 1934; and

2.    The information  contained in the Report fairly presents,  in all material
      respects,  the  financial  condition  and  results  of  operations  of the
      Company.

                                                By: /s/ Elias Vamvakas
                                                    -----------------------
                                                    Elias Vamvakas
                                                    Chief Executive Officer

March 14, 2005