Paula Winner Barnett, Esq. 17967 Boris Drive, Encino, CA 91316 tel (818) 776-9881 fax (818) 743-7491 pwbarnett@sbcglobal.net May 2, 2005 VIA FACSIMILE Tom Jones, Esq. Division of Corporate Finance Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549-0306 Re: Calypte Biomedical Corporation ("Calypte"); Amendment No. 3 to Form SB-2 on Form S-3; Registration No. 333-124344 Dear Mr. Jones: Pursuant to our telephone conversation on Thursday, April 28, 2005, this letter and the attached two tables are furnished to you as supplemental information concerning Calypte's pending Amendment to Registration Statement (as defined below). One table ("Table 1") includes all shares of Calypte's common stock (the "Common Stock") previously registered for resale since January 2004 under Registration Statements on Form SB-2, Nos. 333-119646, 333-116491 and 333-117439 (the "SB-2 Registration Statements") and all shares of Common Stock registrable under Calypte's pending Amendment to Registration Statement. The second table ("Table 2") includes, in addition to certain shares of Common Stock registrable under Calypte's pending Amendment to Registration Statement, shares of Common Stock that are potentially registrable in the future and which Calypte may register in a separate registration statement at a later date. The potentially registrable shares are included on Table 2 to assist your understanding of the various financings Calypte has entered into during the last year. As I indicated, none of the potentially registrable shares listed on Table 2 have been issued and a number of them will only be issued if such issuance is approved by Calypte's stockholders. On Tuesday, April 27, 2005, Calypte filed a Form S-3 with the Securities and Exchange Commission (the "Commission"), entitled Amendment No. 3 to Form SB-2 on Form S-3, Registration Statement No. 333-119646 (the "Amendment to Registration Statement"). The purpose of the Amendment to Registration Statement was to file, pursuant to Rule 429 of the Securities Act of 1933, as amended (the "Securities Act"), a single prospectus to combine and update the SB-2 Registration Statements in order to maintain their effectiveness as required under Section 10(a) of the Securities Act. The combined and updated prospectus was intended to be filed as a post-effective amendment to the latest registration statement, No. 333-119646, under Rule 429(a) and to act as a post-effective amendment to the combined SB-2 Registration Statements to update information contained therein under Rule 429(b). The Amendment to Registration Statement was mistakenly assigned a new registration number, Registration Statement No. 333-124344, apparently because the agent Calypte used to file the Amendment to Registration Statement in the EDGAR system submitted it as a new Form S-3, rather than as a post-effective amendment to Calypte's Form SB-2, Registration Statement Number 333-119646. Tom Jones, Esq. May 2, 2005 Page 2 On May 28, 2004 and July 9, 2004, Calypte sold shares of Common Stock ("Shares") and warrants to purchase Shares (the "Warrants") in two separate, unrelated private placements (the "2004 PIPEs"). Calypte registered for resale the Shares and the Shares underlying the Warrants on Registration Statement No. 333-116491, which became effective on July 8, 2004, and Registration Statement No. 333-117439, which became effective on July 28, 2004. The investors in the May and July 2004 PIPEs (the "2004 PIPE Investors") have certain anti-dilution rights (the "Anti-Dilution Rights"), as set forth in the 2004 PIPEs transaction documents. The Anti-Dilution Rights, when triggered by a subsequent issuance of Common Stock under certain conditions, are: (1) the right to receive additional Shares (the "Additional Shares"); (2) the right to purchase additional Shares under the Warrants (the "Additional Warrant Shares"); and (3) the adjustment of the exercise price of all of the Warrant Shares. Calypte did not register for resale on Registration Statement Nos. 333-116491 and 333-117439 any Shares or Shares underlying the Warrants potentially registrable in connection with a potential triggering of the Anti-Dilution Rights. Only the Shares and Shares underlying the Warrants initially issued were registered for resale. To date, no Warrant Shares have been issued, as none of the Warrants have been exercised. On April 4, 2005, Calypte raised $8,000,000 in a private placement to five institutional investors of convertible notes (the "April 2005 Financing"), which triggered the Anti-Dilution Rights. In order to comply with the rules of the American Stock Exchange (the "AMEX"), Calypte will not issue any Shares or Warrant Shares in connection with the Anti-Dilution Rights without first obtaining stockholder approval of their issuance. Due to timing considerations resulting from Calypte's needs for additional working capital, Calypte had to obtain the funding provided by the April 2005 Financing before seeking stockholder approval of any issuances in connection with the Anti-Dilution Rights. The 2004 PIPE Investors agreed to Calypte's consummation of the April 2005 Financing prior to seeking stockholder approval of issuances and exercise price adjustments in connection with the Anti-Dilution Rights issuable as a consequence of the April 2005 Financing. In order to obtain that agreement of the 2004 PIPE Investors, Calypte agreed to enter into a new agreement with the 2004 PIPE Investors to revise the Anti-Dilution Rights pursuant to the terms of an Amendment to Securities Purchase Agreement dated April 4, 2005 (the "Amendment"). Tom Jones, Esq. May 2, 2005 Page 3 Under the terms of the 2004 PIPEs, as a result of the April 2005 Financing, the 2004 PIPE Investors would have been entitled to receive the following pursuant to the Anti-Dilution Rights: (1) 6,742,500 Additional Shares; (2) 1,193,501 Additional Warrant Shares at an exercise price of $0.45 per share; and (3) An adjustment of the exercise price of the initial 10,741,500 Shares purchasable pursuant to the Warrants from $0.50 to $0.45 per share. Under the terms of the Amendment, the 2004 PIPE Investors are entitled to receive, if approved by the stockholders: (1) 7,079,625 Additional Shares; (2) 1,253,177 Additional Warrant Shares, at an exercise price of $0.325 per share; and (3) An adjustment of the exercise price of the initial 10,741,500 Shares purchasable pursuant to the Warrants from $0.50 to $0.45 per share. Calypte intends to register the Additional Shares and the Shares underlying the Additional Warrant Shares issuable under the Amendment on the same registration statement it may file with the Commission to register Shares in connection with the April 2005 Financing. I trust that this letter and the attached tables demonstrate that Calypte has complied with all applicable rules and regulations of the Commission in connection with the filing of the Amendment to Registration Statement. As I emphasized in my discussion with you, Calypte must respectfully request the Commission's staff prompt review of the Amendment to Registration Statement so that Calypte can thereby fulfill its obligations to the selling security holders to maintain the effectiveness of its registration statements and limit the burden of the penalties Calypte will incur if the effectiveness of the Amendment to Registration Statement is delayed. Calypte's executive officers and I are available to discuss with you any questions or comments you may have in regard to this letter and the tables. Very truly yours, /s/ Paula Winner Barnett Paula Winner Barnett cc: Mr. J. Richard George Mr. Richard Brounstein TABLE 1 Calypte Biomedical Corporation Summary of Shares Registered in 2004 SB-2's and Carried forward in April 2005 S-3 Shares Sold or carried Shares registered for resale in SB-2s Eligible forward ----------------------------------------------------- for resale in S-3 8-Jul-04 28-Jul-04 29-Dec-04 under ------------ Selling Security Holder 333-116491 333-117439 333-119646 Total Section 144 333-124344 ----------------------------------------------- ----------------------------------------------------- ------------ ------------ Shares for transactions preceding May 2004 PIPE Stonestreet Limited Partnership 321,954 321,954 321,954 - SDS Capital International Ltd. 1,266,600 1,266,600 1,266,600 - Compass Strategic Corporation 1,500,000 1,500,000 1,500,000 - Mercator Momentum Fund, L.P. 704,474 704,474 604,474 100,000 Mercator Focus Fund, L.P. 3,100,801 3,100,801 - 3,100,801 Gamma Opportunity Capital Partners, LP 349,358 349,358 349,358 - Goldplate Investment Partners 418,796 418,796 418,796 - Khalid B. Ahmed, M.D. Pension Plan 84,602 84,602 84,602 - Roger Suyama 33,841 33,841 33,841 - Logisticorp, Inc. 213,903 213,903 - 213,903 Southwest Resource Preservation Inc. 427,807 427,807 - 427,807 Ace Global Ltd. 153,846 153,846 153,846 - Piter Korompis 461,538 461,538 461,538 - Net Capital Partners, Inc. 1,637,998 1,637,998 1,637,998 - Langdale Profits Limited 769,231 769,231 769,231 - Synergyworks, Ltd. 1,538,462 1,538,462 1,538,462 - Marr Technologies BV (1) 34,015,151 34,015,151 33,515,151 500,000 Top Calibre Enterprise Limited 775,000 775,000 - 775,000 David Miller 6,250 6,250 6,250 - Antonella Popoff 6,250 6,250 6,250 - Jack W. Reich 6,250 6,250 6,250 - Rona Taylor 6,250 6,250 6,250 - Ernesto Cardenas 100,000 100,000 100,000 - CEOCast, Inc. 400,000 400,000 400,000 - European Equity Group 100,000 100,000 100,000 - New York University 525,000 525,000 525,000 - Platinum Partners Value Arbitrage Fund 675,625 675,625 675,625 - Alfonso Saavedra 100,000 100,000 100,000 - Vintage Filings 46,875 46,875 46,875 - John M. Ennis 26,131 26,131 26,131 - Paul R. Smith 3,056 3,056 3,056 - Kyle Ryan 458 458 458 - Michael Schmidt 458 458 458 - Joseph M. Staebler 458 458 458 - Magic Johnson Foundation 200,000 200,000 133,333 66,667 Pointe Investments, Ltd. 500,000 500,000 500,000 - Craig Enenstein 100,000 100,000 - 100,000 Michael Rovens 100,000 100,000 100,000 - Adaltis, Inc. 212,127 212,127 - 212,127 Merchant Intercapital 150,000 150,000 - 150,000 May 2004 PIPE Investors SF Capital Partners LP 13,500,000 13,500,000 - 13,500,000 Marr Technologies BV (1) 10,125,000 10,125,000 - 10,125,000 Proximity Fund LP 1,687,500 1,687,500 1,250,000 437,500 Proximity Partners LP 1,687,500 1,687,500 1,250,000 437,500 MTB Small Cap Growth Fund 1,687,500 1,687,500 - 1,687,500 MTB Multi Cap Growth Fund 1,687,500 1,687,500 - 1,687,500 Bridges & PIPES LLC 1,012,500 1,012,500 750,000 262,500 ------------ ------------ ------------ ------------ 31,387,500 31,387,500 3,250,000 28,137,500 Fees Duncan Capital LLC (2) 30,000 30,000 - 30,000 Capstone Investments 600,000 600,000 - 600,000 July 2004 PIPE Investors Sunrise Equity Partners, L.P. 3,187,500 3,187,500 1,875,000 1,312,500 Amnon Mandelbaum 340,000 340,000 200,000 140,000 David I Goodfriend 34,000 34,000 20,000 14,000 TCMP3 Partners 637,500 637,500 375,000 262,500 United Capital Partners, LLC 2,125,000 2,125,000 - 2,125,000 ------------ ------------ ------------ ------------ 6,324,000 6,324,000 2,470,000 3,854,000 Fees Duncan Capital LLC (2) 148,800 148,800 - 148,800 Ani Biotech Oy 1,172,205 1,172,205 - 1,172,205 ----------------------------------------------------- ------------ ------------ Total Shares Registered 83,056,050 6,472,800 1,172,205 90,701,055 51,112,245 39,588,810 ===================================================== ============ ============ (1) Sum of Marr Technologies BV 44,140,151 - - 44,140,151 33,515,151 10,625,000 (2) Sum of Duncan Capital 30,000 148,800 - 178,800 - 178,800 (3) Shares transferred by Mercator Focus Fund to The Vechery Family Trust in a transaction not involving the Company; shares registered in S-3 on behalf of The Vechery Family Trust. The Company was advised that no consideration was exchanged between the parties in connection with the transfer. (4) Warrant assigned by Proximity Partners LP to Proximity Fund LP in a transaction not involving the Company; shares underlying the warrant registered in S-3 on behalf of Proximity Fund LP. The Company was advised that no consideration was exchanged between the parties in connection with the assignment. (5) Warrant to purchase 300,000 shares transferred by Capstone Investments to 3 parties in a transaction not involving the Company. The Company was advised that no consideration was exchanged between the parties in connection with the transfer. The original 600,000 shares are registered in the S-3 as follows: Capstone Investments 300,000 The Capozza Family Trust 128,572 Anthony M. Capozza 128,572 Ann L. Capozza 42,856 ------------- 600,000 ============= SUMMARY OF SB-2 SELLING STOCKHOLDERS TABLE 2 Calypte Biomedical Corporation Analysis of May 2004, July 2004 and April 2005 Shares PLACEMENTS FOR WHICH REGISTRATION STATEMENT HAS NOT YET BEEN FILED ------------------------------------------------------------ Shares carried forward Shares potentially issuable in S-3, 333-124344 under April 2005 Financing(1) ----------------------------------- ------------------------------------------------------------ PIPE Shares 8% Interest Series Series Shares underlying Convertible on A B issued Warrants(5) Total Notes Notes(4) Warrants Warrants Total ----------------------------------- ------------------------------------------------------------ May 2004 PIPE SF Capital Partners LP 10,000,000 3,500,000 13,500,000 13,333,333 2,322,858 13,333,333 6,000,000 34,989,524 Marr Technologies BV 7,500,000 2,625,000 10,125,000 9,333,333 1,626,000 9,333,333 4,200,000 24,492,666 Proximity Fund LP - 875,000 875,000 Proximity Partners LP - - - MTB Small Cap Growth Fund 1,250,000 437,500 1,687,500 MTB Multi Cap Growth Fund 1,250,000 437,500 1,687,500 Bridges & PIPES LLC - 262,500 262,500 ----------------------------------- 20,000,000 8,137,500 28,137,500 ----------------------------------- July 2004 PIPE Sunrise Equity Partners, L.P. - 1,312,500 1,312,500 Amnon Mandelbaum - 140,000 140,000 David I Goodfriend - 14,000 14,000 TCMP3 Partners - 262,500 262,500 United Capital Partners, LLC 1,250,000 875,000 2,125,000 ----------------------------------- 1,250,000 2,604,000 3,854,000 ----------------------------------- 21,250,000 10,741,500 31,991,500 =================================== Others in April 2005 Placement Morningtown Limited 1,500,000 261,321 1,500,000 675,000 3,936,321 Smithfield Fiduciary LLC 1,666,667 290,357 1,666,667 750,000 4,373,691 Iroquois Master Fund Ltd. 833,333 145,179 833,333 375,000 2,186,845 ------------------------------------------------------------ 26,666,666 4,645,715 26,666,666 12,000,000 69,979,047 =========================================================== PLACEMENTS FOR WHICH REGISTRATION STATEMENT HAS NOT YET BEEN FILED -------------------------------------------------------------------------------------------- Shares originally issuable under 2004 PIPEs (2) Shares issuable under the Amendment (3) ----------------------------------- ------------------------------------------------------- Additional Warrants Total Additional Warrants Warrants Total Shares @ $0.45 Shares Shares Shares @$0.325 @ $0.325 Shares ----------------------------------- ------------------------------------------------------- May 2004 PIPE SF Capital Partners LP 2,500,000 388,889 2,888,889 2,500,000 125,000 388,889 19,444 3,033,333 Marr Technologies BV 1,875,000 291,667 2,166,667 1,875,000 93,750 291,667 14,583 2,275,000 Proximity Fund LP 312,500 48,611 361,111 312,500 15,625 48,611 2,431 379,167 Proximity Partners LP 312,500 48,611 361,111 312,500 15,625 48,611 2,431 379,167 MTB Small Cap Growth Fund 312,500 48,611 361,111 312,500 15,625 48,611 2,431 379,167 MTB Multi Cap Growth Fund 312,500 48,611 361,111 312,500 15,625 48,611 2,431 379,167 Bridges & PIPES LLC 187,500 29,167 216,667 187,500 9,375 29,167 1,458 227,500 ------------------------------------ ------------------------------------------------------- 5,812,500 904,167 6,716,667 5,812,500 290,625 904,167 45,209 7,052,501 July 2004 PIPE Sunrise Equity Partners, L.P. 468,750 145,833 614,583 468,750 23,438 145,833 7,292 645,313 Amnon Mandelbaum 50,000 15,556 65,556 50,000 2,500 15,556 778 68,834 David I Goodfriend 5,000 1,556 6,556 5,000 250 1,556 78 6,884 TCMP3 Partners 93,750 29,167 122,917 93,750 4,688 29,167 1,458 129,063 United Capital Partners, LLC 312,500 97,222 409,722 312,500 15,625 97,222 4,861 430,208 ------------------------------------ ------------------------------------------------------- 930,000 289,334 1,219,334 930,000 46,500 289,334 14,467 1,280,301 ------------------------------------ ------------------------------------------------------- 6,742,500 1,193,501 7,936,001 6,742,500 337,125 1,193,501 59,676 8,332,802 ==================================== ======================================================= Others in April 2005 Placement 7,079,625 1,253,177 ========== ========== Morningtown Limited Smithfield Fiduciary LLC Iroquois Master Fund Ltd. (1) Does not include notes and warrants issued to finders. (2) Number of shares and warrants the 2004 PIPE investors are entitled to receive under the anti-dilution provisions of the 2004 PIPEs, which were triggered by the sale of securities in the April 2005 Financing. (3) Shares and warrants the 2004 PIPE investors will receive, if approved by stockholders, as consideration for making the issuance of their anti-dilution shares and warrants subject to stockholder approval. (4) Assumes Notes are held to maturity and quarterly interest accretes to Note principal. (5) Warrants will be repriced from $0.50 per share to $0.45 per share under the terms of the 2004 PIPEs.