UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursuant to Section 14(a) of
                       the Securities Exchange Act of 1934

Filed by the Registrant    |X|

Filed by a Party other than the Registrant    |_|

Check the appropriate box:

|_| Preliminary Proxy Statement                   |_| Confidential, for Use of
                                                      the Commission Only
|X| Definitive Proxy Statement                        (as permitted by Rule
                                                      14a-6(e)(2))
|_| Definitive Additional Materials

|_| Soliciting Material Pursuant to ss.240.14a-12

                         CALYPTE BIOMEDICAL CORPORATION
                (Name of Registrant as Specified In Its Charter)

       (Name of Person(s) Filing Proxy Statement if other than Registrant)


Payment of Filing Fee (Check the  appropriate  box):

|X| No fee required

|_| Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

    (1) Title of each class of securities to which transaction applies:

    (2) Aggregate number of securities to which transaction applies:

    (3) Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (set forth the amount on which the
        filing fee is calculated and state how it was determined):

    (4) Proposed maximum aggregate value of transaction:

    (5) Total fee paid:

|_| Fee paid previously with preliminary materials.

|_|  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the filing for which the  offsetting  fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

    (1) Amount Previously Paid:

    (2) Form, Schedule or Registration Statement No.:

    (3) Filing Party:

    (4) Date Filed:


                                       1


                                [GRAPHIC OMITTED]
                          5000 Hopyard Road, Suite 480
                              Pleasanton, CA 94588


June 1, 2005

Dear Stockholder:

      You are cordially invited to attend Calypte Biomedical  Corporation's 2005
Annual  Meeting of  Stockholders  on Thursday,  June 30, 2005.  The meeting will
begin  promptly at 10:00 a.m.  local time,  at the Four Points  Sheraton  Hotel,
located at 5115 Hopyard Road, Pleasanton, CA 94588.


      The official Notice of Annual Meeting of  Stockholders,  Proxy  Statement,
form of proxy,  2004 Annual Report to Stockholders  and our Quarterly  Report on
Form 10-QSB for the quarter ended March 31, 2005 are  included  with this letter
The matters listed in the Notice of Annual Meeting of Stockholders are described
in detail in the Proxy Statement, which you are urged to review carefully.


      Your  vote is  important.  Whether  or not you plan to attend  the  annual
meeting,  I urge you to  complete,  sign and date the  enclosed  proxy  card and
return it in the  accompanying  envelope or vote by telephone or on-line as soon
as possible so that your stock may be represented at the meeting.


                                                          Sincerely,

                                                          /s/ J. Richard George
                                                          ----------------------
                                                          J. Richard George
                                                          President and CEO


                                       2




                                [GRAPHIC OMITTED]
                          5000 Hopyard Road, Suite 480
                              Pleasanton, CA 94588

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                           To be held on June 30, 2005

June 1, 2005

      NOTICE IS HEREBY  GIVEN that the 2005 Annual  Meeting of  Stockholders  of
Calypte  Biomedical  Corporation (the "Company") will be held at the Four Points
Sheraton Hotel located at 5115 Hopyard Road, Pleasanton,  California,  94588, on
Thursday, June 30, 2005, at 10:00 a.m. local time, for the following purposes:


      1.    To elect five directors of the Company to hold office until the next
            Annual  Meeting  of  Stockholders  or  until  their  successors  are
            elected.

      2.    To vote on a proposal  to approve  the  issuance of shares of common
            stock in excess of 19.99% of the outstanding  common stock and price
            adjustments in connection  with our April 2005 issuance of Notes and
            Warrants;

      3.    To vote on a proposal to approve the issuance of  additional  shares
            of common  stock and warrant  shares and  adjustment  of the warrant
            exercise price in connection  with amended  securities  granted to 3
            the investors in our May and July 2004 placements;

      4.    To vote on a proposal to adopt the Company's 2005 Director Incentive
            Plan (Appendix A hereto) and to authorize  18,000,000  shares of the
            Company's Common Stock for issuance thereunder;

      5.    To vote on a proposal to amend the  Company's  2004  Incentive  Plan
            (Appendix B hereto) to increase by 17,000,0000  shares the number of
            shares  of  the  Company's  Common  Stock  authorized  for  issuance
            thereunder;  to permit awards to employees,  consultants  and others
            who provide services to affiliates of the Company thereunder; and to
            increase to  20,000,000  shares the number of shares of Common Stock
            available  for delivery as  restricted  stock and  restricted  stock
            units thereunder;

      6.    To ratify the  appointment  by the Audit  Committee and the Board of
            Directors of Odenberg Ullakko Muranishi & Co. LLP as the independent
            registered public accounting firm to audit the Company's 6 financial
            statements for the fiscal year ending December 31, 2005; and

      7.    To  transact  such other  business as may  properly  come before the
            Annual Meeting or any adjournment thereof.

      Stockholders  of record on May 9,  2005 will be  eligible  to vote at this
meeting.  Only stockholders of record at the close of business on that date will
be  entitled  to  notice  of  and  to  vote  at  the  meeting.  To  ensure  your
representation at the meeting,  you are urged to mark, sign, date and return the
enclosed  proxy as promptly as possible in the envelope  provided or to vote via
the internet or by telephone.  If you attend the meeting, you may vote in person
even if you return a proxy.


                                          By order of the Board of Directors,

                                          /s/  J. Richard George
                                          J. Richard George
                                          President and Chief Executive Officer


                             YOUR VOTE IS IMPORTANT

Whether or not you plan to attend the  meeting,  please  complete and return the
proxy card in the envelope provided,  which requires no postage if mailed in the
United States.


                                       3


                                [GRAPHIC OMITTED]

                          5000 Hopyard Road, Suite 480
                              Pleasanton, CA 94588

                                 PROXY STATEMENT

      This Proxy Statement is furnished in connection  with the  solicitation of
proxies on behalf of the Board of Directors (the "Board") of Calypte  Biomedical
Corporation  ("Calypte" or the "Company") for the Annual Meeting of Stockholders
(the "Annual  Meeting"),  and any postponements or adjournments  thereof,  to be
held at the Four Points Sheraton Hotel located at 5115 Hopyard Road, Pleasanton,
California  94588,  on Thursday,  June 30, 2005, at 10:00 a.m.  local time.  The
telephone  number at that address is (925)  460-8800.  Every  stockholder on the
Record  Date  shall  have the right to vote  whether in person or by one or more
agents  authorized by a written proxy signed by the  stockholder  and filed with
the secretary of the Company.  The shares  represented by the proxies  received,
properly  dated  and  executed,  and not  revoked  will be voted  at the  Annual
Meeting. A proxy may be revoked at any time before it is exercised by delivering
to the Company a written notice of revocation or a duly executed proxy bearing a
later date or by attending the Annual  Meeting and voting in person.  This Proxy
Statement  and  the  accompanying  form of  proxy  are  first  being  mailed  to
stockholders of the Company on or about June 1, 2005.

                 INFORMATION CONCERNING SOLICITATION AND VOTING

      The close of  business  on May 9, 2005 has been fixed as the  record  date
(the "Record Date") for determining the holders of shares of common stock of the
Company,  par value $0.03 per share,  ("Common Stock") entitled to notice of and
to vote at the Annual  Meeting.  At May 9, 2005,  the  Company  had  171,243,303
shares of Common Stock  outstanding  and entitled to vote at the Annual Meeting.
The  holders  of a  majority  of voting  power of the  Common  Stock  issued and
outstanding  and entitled to vote,  present in person or  represented  by proxy,
shall constitute a quorum at the Annual Meeting except as otherwise  provided by
statute.  Each holder of Common Stock on the Record Date is entitled to one vote
for each share of Common Stock held by such stockholder,  and stockholders shall
not be entitled to cumulate  their votes in the  election of  directors  or with
respect to any matter submitted to a vote of the stockholders.

      Shares represented by proxies that reflect abstentions or broker non-votes
will be counted as shares that are present and  entitled to vote for purposes of
determining  the presence of a quorum.  Directors will be elected by a favorable
vote of a plurality of the shares of voting stock  present and entitled to vote,
in person or by proxy, at the Annual Meeting. Accordingly, abstentions or broker
non-votes as to the  election of  directors  will not affect the election of the
candidates receiving the plurality of votes. All of the proposals to come before
the Annual  Meeting  require  the  approval of a majority of the shares of stock
having voting power present.  Abstentions as to a particular  proposal will have
the same effect as votes against such proposal. Broker non-votes,  however, will
be treated as not voted for purposes of  determining  approval of such  proposal
and will not be counted as votes for or against such proposal.

      The shares  represented by all valid proxies received will be voted in the
manner specified on the proxies.  Where specific choices are not indicated,  the
shares  represented  by all valid proxies  received  will be voted:  (1) for the
nominees  for  director  named in the Proxy  Statement;  (2) for the approval to
issue shares of our common stock in excess of 19.99% of our  outstanding  common
stock and price adjustments in connections with our April 2005 issuance of notes
and warrants;  (3) for the approval to issue additional  shares and warrants and
to adjust the warrant  exercise price in connection with the amended  securities
granted to the investors in our May 2004 and July 2004 private  placements;  (4)
for  adoption  of the 2005  Director  Incentive  Plan and the  authorization  to
reserve  shares  for  issuance  thereunder;  (5) for the  amendment  to the 2004
Incentive  Plan and the increase in authorized  shares for issuance  thereunder;
and (6) for ratification of the appointment of Odenberg Ullakko  Muranishi & Co.
LLP, as the Company's registered independent public accounting firm for the year
ending December 31, 2005.

      Should any matter not  described  above be acted upon at the meeting,  the
persons named in the proxy form will vote in accordance with their judgment.

      All costs of soliciting proxies will be borne by the Company.  In addition
to the  solicitation  of proxies by mail,  solicitations  may be made by certain
directors,  officers and other  employees of the Company by personal  interview,
telephone  or  facsimile.  No  additional  compensation  will be paid  for  such
solicitation.  The Company may also, at its discretion, retain the services of a
paid solicitor to solicit  proxies.  If the Company  retains a solicitor,  it is
anticipated that the cost will be approximately  $10,000 and will be paid by the
Company.  The Company will request  brokers and nominees who hold stock in their
names to furnish  proxy  material  to  beneficial  owners of the shares and will
reimburse such brokers and nominees for their  reasonable  expenses  incurred in
forwarding solicitation material to such beneficial owners.


                                       1


                              ELECTION OF DIRECTORS
                                  (Proposal 1)

      At the Annual  Meeting,  five  directors  are to be elected to hold office
until the 2006  Annual  Meeting or until  their  successors  are  elected.  Each
director,  including a director  elected or appointed  to fill a vacancy,  shall
hold  office  until the  expiration  of the term for which  elected  and until a
successor  has been  elected or  appointed  and  qualified.  There are no family
relationships  among any of the directors or executive  officers of the Company.
The nominees listed below are all now Calypte  directors.  The Board knows of no
reason why any nominee may be unable or unwilling to serve as a director. If any
nominee is unable or unwilling  to serve,  the shares  represented  by all valid
proxies  will be voted for the  election  of such other  person as the Board may
recommend.  The nominees  receiving the highest number of affirmative votes will
be elected to the Board.

      Following is a list of our Directors and Executive  Officers as of May 13,
2005.



Name                             Age               Calypte Position; Principal Occupation                   Director Since
- ----                             ---               --------------------------------------                   --------------
                                                                                                   

Roger I. Gale                    52         Chairman; Chairman, Wavecrest Group
                                              Enterprises Limited                                                 11/04

John J. DiPietro                 46         Director; Chief Financial Officer, Chronix
                                              Biomedical, Inc.                                                    10/99

Paul E. Freiman                  70         Director; President and Chief Executive Officer,
                                              Neurobiological Technologies, Inc.                                  12/97

Julius R. Krevans, M.D.          81         Director; Retired Chancellor Emeritus, Director
                                              of International Medical Services University of
                                              California, San Francisco                                           3/95

Maxim A. Soulimov                33         Director; Director of Legal Affairs, Global
                                              Corporate Ventures, Limited                                         4/04

J. Richard George, Ph.D.         63         President and Chief Executive Officer,
                                              Calypte Biomedical Corporation                                      N/A

Richard D. Brounstein            55         Executive Vice President and Chief Financial Officer,
                                              Calypte Biomedical Corporation                                      N/A

Richard R. Van Maanen            45         Vice-President - Operations and International Business
                                              Development, Calypte Biomedical Corporation                         N/A


      Roger I.  Gale was  appointed  to the  Company's  Board of  Directors  and
elected  Chairman in November  2004.  Mr. Gale has served since  October 2001 as
Executive  Chairman of the Board of  Directors of  Wavecrest  Group  Enterprises
Limited, a United Kingdom-based  communications  service provider.  He is also a
founder  and  director  of  Starnorth   Limited,   a  communications  and  media
consultancy.  From 1999 to 2001,  he was  Chairman  and  co-founder  of  End2End
Wireless Limited, a UK wireless access services provider.  Mr. Gale has lectured
in economics at the University of New England  (Australia)  and Lincoln  College
(New  Zealand).  He  serves  as a  Director  of Mechel  Steel  Group,  a Russian
corporation  recently listed on the New York Stock Exchange (NYSE:  "MTL").  Mr.
Gale holds a Master of  Economics  degree from the  University  of New  England,
Australia and a Higher  National  Diploma from the Royal  Agricultural  College,
Cirencester,  Gloucestershire,  England.  Mr.  Gale  is  one  of  two  Directors
appointed to the Company's  Board pursuant to an August 2003  agreement  between
the Company and Marr  Technologies BV ("Marr").  Marr is currently the Company's
largest  stockholder,  holding  approximately  27% of the Company's  outstanding
common stock.


      John J.  DiPietro  was  elected to the  Company's  Board of  Directors  in
October 1999. Since September 2002, he has served as the Chief Financial Officer
of Chronix Biomedical Inc, a private biotechnology company. Since February 2003,
Mr.  DiPietro  has also been a member of the Board of Chronix  Biomedical.  From
September  1999 to September  2002 he had been the Chief  Financial  Officer and
Vice  President-Finance  and  Administration  of  Tripath  Technology,  Inc.,  a
semi-conductor  manufacturing  company.  He served as Calypte's  Chief Operating
Officer,  Vice President of Finance,  Chief Financial Officer and Secretary from
December 1997 through  September 1999. From October 1995 until December 1997, he
served as Calypte's  Vice  President  of Finance,  Chief  Financial  Officer and
Secretary.  He is a Certified Public Accountant and received his M.B.A. from the
University of Chicago, Graduate School of Business and a B.S. in Accounting from
Lehigh University.


                                       2


      Paul E. Freiman has served as a member of the Company's Board of Directors
since December 1997. He has served as the President and Chief Executive  Officer
of  Neurobiological  Technologies,  Inc.  since May 1997. In 1995,  Mr.  Freiman
retired  from his  position as Chairman  and Chief  Executive  Officer of Syntex
Corporation,  a pharmaceutical  company. Mr. Freiman is currently serving on the
board of Penwest Pharmaceuticals Inc. and Neurobiological Technologies,  Inc and
several  private   biotechnology   companies.   He  has  been  chairman  of  the
Pharmaceutical  Manufacturers  Association  of  America  (PhARMA)  and has  also
chaired a number of key  PhARMA  committees.  Mr.  Freiman is also an advisor to
Burrill & Co., a San Francisco merchant bank.

      Julius R.  Krevans,  M.D. has served on the  Company's  Board of Directors
since March 1995.  Dr.  Krevans  served as  Chancellor  Emeritus and Director of
International  Medical Care at University  of  California at San Francisco  from
1993 until his  retirement  in June 2002.  He is also  Chairman  of the Board of
Directors of Neoprobe  Corporation.  Dr. Krevans received his M.D. from New York
University,  College of Medicine and  completed a residency in Medicine at Johns
Hopkins University School of Medicine.

      Maxim A.  Soulimov was  appointed to the  Company's  Board of Directors in
April 2004.  Since November  2002, Mr.  Soulimov has served as Director of Legal
Affairs of Global  Corporate  Ventures  Limited  ("GCVL")  of London,  a company
providing  consultancy services to a variety of private investors including Marr
and its affiliates. From April 2000 through October 2002, Mr. Soulimov served as
in-house  legal  counsel for Lukoil Europe  Limited and Lukoil  Europe  Holdings
Limited,  private companies  involved in the management of all Lukoil downstream
companies outside the Russian Federation. From September 1997 to April 2000, Mr.
Soulimov served as Trainee and then as Assistant Solicitor in the London firm of
Norton Rose  Solicitors.  Mr.  Soulimov holds a Degree in Modern  Languages from
Tver  State  University  in Russia  and an LLB Law  degree  from  University  of
Hertfordshire  in the  United  Kingdom.  Mr.  Soulimov  is one of two  Directors
appointed to the Company's  Board pursuant to an August 2003  agreement  between
the Company and Marr.

      J.  Richard  George,  Ph.D.  has served as Calypte's  President  and Chief
Executive  Officer since January 2004.  Dr. George joined the Company in January
2003 as Vice President - Government Affairs.  From September 2000 to March 2002,
Dr. George served as Senior Vice President - Research & Development,  Infectious
Diseases at Orasure  Technologies,  Inc. (Nasdaq:  OSUR). Dr. George served from
April 1995  through  August 2000 as Chief  Science  Officer of Epitope,  Inc. (a
predecessor company to Orasure  Technologies,  Inc.). Dr. George was employed in
various roles at the Centers for Disease Control and Prevention  (CDC) from 1960
to  1995.  He left  the CDC in 1995 as  Chief  of the  Developmental  Technology
Section,  Laboratory  Investigations  Branch of the  Division of  HIV/AIDS.  Dr.
George  received his Ph.D. in  Microbiology  from the University of Georgia;  he
received his Master of Science and B.S.  degrees in Biology  from Georgia  State
University.

      Richard D.  Brounstein  has served as Executive  Vice  President and Chief
Financial  Officer since  joining  Calypte in December  2001,  following a short
period in which he served as a financial  consultant  and  interim  CFO. He also
served as member of the Board of Directors  from  December  2001 until May 2003,
when he did not stand for re-election.  Prior to joining Calypte, Mr. Brounstein
served  as Chief  Financial  Officer  for  Certicom  Corporation,  a mobile  and
wireless  software  security  company from 2000 to 2001.  From 1997 to 2000, Mr.
Brounstein served as Chief Financial  Officer for VidaMed,  Inc., a growth-stage
medical  device  company.  In March 2005 he was  appointed  to the SEC  Advisory
Committee on Smaller  Public  Companies,  where Mr.  Brounstein  will  represent
micro-cap companies and companies in the life sciences industry. The role of the
advisory  committee is to advise the SEC on how best to assure that the costs of
regulation for smaller  companies  under the Act and other  securities  laws are
commensurate  with the benefits.  Mr.  Brounstein is a CPA; he received both his
MBA in Finance and his BA in Accounting from Michigan State University.

      Richard   Van  Maanen  has   served  as  Vice   President-Operations   and
International  Business  Development  since January 2004.  Mr. Van Maanen joined
Calypte in March  1993 as  Director  of Sales and  Marketing.  He was  appointed
Director of International  Business  Development in January 2001. Mr. Van Maanen
received his B.S. with honors from the University of Guelph, Canada.

Approval Required

      Approval of Proposal 1 requires the affirmative vote of a plurality of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.

      The Board  unanimously  recommends  a vote FOR the  election  of all named
nominees.  Proxies  solicited by the Board will be so voted unless  stockholders
specify a different choice in their proxies.

                      THE BOARD OF DIRECTORS AND COMMITTEES

      Our Board of Directors  directs the management of our business and affairs
as provided by Delaware law and conducts  its business  through  meetings of the
full board of directors and three standing committees:  the Audit Committee, the
Compensation  Committee and the  Nominating  Committee.  The charter for each of
these  committees is available on our website at  www.calypte.com.  From time to
time  when  necessary,  the  Board  may  establish  other  committees  under its
direction to address  specific  issues.  The Board of Directors met 14 times and
acted by unanimous  written consent 4 times during 2004.  During 2004, the Audit
Committee met 8 times,  the  Compensation  Committee met twice and acted once by
unanimous written consent and the Nominating Committee met once and acted once
by  unanimous  written  consent.  All  directors  attended at least 75% of the
aggregate  number of meetings of the Board and the standing  committees on which
they served in 2004 during the period in which they served as directors.

      The Audit Committee  currently includes three independent  Directors,  Mr.
Freiman as Chairman,  Mr. DiPietro and Dr. Krevans. As described in its Charter,
the duties and  responsibilities of the Audit Committee include  recommending to
the Board of Directors the  appointment  or termination of the engagement of our
independent public  accountants,  otherwise  overseeing the independent  auditor
relationship,   reviewing  our  significant  accounting  policies  and  internal
controls and  reporting  its  recommendations  and findings to the full Board of
Directors.  The Board has determined that Messrs. Freiman and DiPietro are Audit
Committee  financial  experts as defined by Item 401(e) of Regulation S-B of the
Securities  Exchange Act of 1934 (the "Exchange Act") and are independent within
the meeting of Item 7(d)(3)(iv) of Schedule 14A of the Exchange Act.

      The Compensation  Committee currently includes Dr. Krevans as Chairman and
Mr. Freiman. As described in its Charter, the Compensation Committee reviews and
approves the  compensation  of our Chief  Executive  Officer and Chief Financial
Officer,  recommends to the Board the  compensation  of members of the Board and
administers our stock option and other benefit plans.


                                       3


      The Nominating  Committee  currently  includes Mr. Freiman as Chairman and
Dr. Krevans. As described in its Charter,  the Nominating  Committee assists the
Board in  fulfilling  its oversight  responsibilities  relating to the Company's
corporate  governance  matters,  including the determination of the independence
status of current and  prospective  Board  members,  periodic  evaluation of the
Board  of  Directors,   its  committees  and  individual   directors,   and  the
identification and selection of director nominees.

      The   Nominating   Committee   will  consider   candidates   nominated  by
stockholders in accordance  with the procedures set forth in Calypte's  by-laws.
Under  Calypte's  by-laws,  nominations  other  than  those made by the Board of
Directors or the Nominating  Committee must be made pursuant to timely notice in
proper written form to the secretary of Calypte.  To be timely,  a stockholder's
request to nominate a person for  election to the Board at an annual  meeting of
stockholders,  together  with the  written  consent of such person to serve as a
Director,  must be received by the Corporate  Secretary of Calypte not less than
120 days prior to the anniversary of the annual meeting of shareholders  held in
the prior year. To be in proper  written form,  the notice must contain  certain
information   concerning  the  nominee  and  the   shareholder   submitting  the
nomination.

                              DIRECTOR COMPENSATION


      We  reimburse  our  Directors  for  their  out-of-pocket  travel  expenses
associated  with  their  attendance  at  Board  meetings.  We did not  pay  cash
compensation to any of our non-employee  Directors in 2004 or thereafter.  Under
the  terms  of  the  1995  Director  Option  Plan  (the  "Director  Plan"),  our
non-employee  directors  are  eligible to receive  grants of options to purchase
shares of our common stock. The  Compensation  Committee of the Board recommends
and the Board  approves the number of  non-qualified  stock  options to purchase
shares of common  stock  that will be  granted  each year to  newly-elected  and
re-elected directors. Each option granted under the Director Plan is exercisable
at 100% of the fair market  value of our common stock on the date such option is
granted.  Each grant vests monthly over the twelve month period  commencing with
the director's date of election or re-election;  however, the option will become
vested  and  fully  exercisable  on the  date  of the  next  annual  meeting  of
stockholders  if such meeting  occurs less than twelve  months after the date of
the grant.  The Director Plan expires in 2005.  In Proposal 4 in this proxy,  we
are  seeking  stockholder  approval  for a new  plan  for  the  benefit  of  our
non-employee directors.


      The  following  table shows the number of shares of common stock  issuable
upon exercise of options  granted to  non-employee  Directors under the Director
Plan during the fiscal year ended December 31, 2004 and through April 30, 2005.


                                                                    Number of
                       Name and Position                            Options(1)
                       -----------------                            ----------
Roger I. Gale, Director (2)                                          200,000
John J. DiPietro, Director                                           200,000
Paul E. Freiman, Director                                            200,000
Julius Krevans M.D., Director                                        200,000
Otsuka Pharmaceuticals Co Ltd. (Zafar Randawa, Director) (3)         200,000
Maxim A. Soulimov, Director (4)                                      200,000

- ----------

(1)   All options were granted at fair market value on the date of grant. Unless
      otherwise  noted,  each  non-employee  Board member was granted options to
      purchase  200,000  shares at $0.585 per share in February 2004 for service
      on the Board in 2004.

(2)   Mr. Gale was granted options to purchase 200,000 shares at $0.31 per share
      in January 2005 pursuant to his  appointment  in November 2004 as a member
      of and Chairman of the Board.

(3)   Dr. Randawa served as a member of the Board as a representative  of Otsuka
      Pharmaceuticals  under the terms of a previous investment  agreement.  Dr.
      Randawa resigned as a member of the Board effective June 30, 2004.

(4)   Mr. Soulimov was granted  options to purchase  200,000 shares at $0.56 per
      share in April 2004 pursuant to his appointment as a member of the Board.

                      INFORMATION ON EXECUTIVE COMPENSATION


      The  following  table sets forth certain  compensation  that we awarded or
paid to persons who served as our Chief Executive  Officer and as our other most
highly  compensated  executive  officers  in  2004  (collectively,   the  "Named
Executive  Officers") for the years ended December 31, 2004,  2003 and 2002. The
compensation  table excludes other  compensation  in the form of perquisites and
other  personal  benefits  that  constitute  the lesser of $50,000 or 10% of the
total  salary and bonus earned by each of the named  Executive  Officers in each
fiscal year.



                                       4


                           Summary Compensation Table



                                                                                             Long-Term
                                                                                            Compensation
                                                                                             Securities
                                                                                             Underlying
                                                                                               Options             All Other
           Name and Principal Position            Year        Salary ($)       Bonus ($)      Granted (1)       Compensation ($)
           ---------------------------            ----        ----------       ---------      -----------       ----------------
                                                                                                   
Anthony J. Cataldo (2)                            2004        385,846                 0      5,000,000(3)         150,825(4)
   Former Executive Chairman                      2003        445,667(5)              0      2,492,341(6)               0
      of the Board                                2002        185,726(5)              0         30,000(6)               0
J. Richard George (7)                             2004        251,478                 0      5,000,000(3)               0
   Chief Executive Officer and                    2003        135,692                 0        103,494(8)               0
      President
Jay Oyakawa (9)                                   2004         28,269                 0        750,000(9)         350,000(9)
   Former President and Chief                     2003        209,941                 0              0                  0
      Operating Officer and Member of
      the Board
Richard D. Brounstein (10)                        2004        212,677                 0      1,500,000(3)               0
   Executive Vice President and                   2003        201,792                 0        757,371(11)              0
      Chief Financial Officer; Former             2002        122,596            15,000              0                  0
      Member of the Board
Richard R. VanMaanen (12)                         2004        203,630                 0      2,000,000(3)               0
   Vice President-Operations and                  2003        148,236                 0        131,636(13)         98,248(14)
      International Business Development          2002        131,729                 0         12,570(15)              0


- ----------

(1)   All figures in this column  represent  options to purchase  the  Company's
      common stock.

(2)   Mr.  Cataldo  served as  Executive  Chairman  of the  Board  from May 2002
      through  November  2004.  Concurrent  with his  joining the Company in May
      2002, the Company entered into a five-year  Employment  Agreement with Mr.
      Cataldo that required an annual salary of $400,000.  Mr. Cataldo  resigned
      effective  November 15, 2004 as the Company's  Executive Chairman and as a
      member of its Board of  Directors.  Under  the terms of a  Separation  and
      Consulting  Agreement and Release of Claims  effective  November 15, 2004,
      the Company agreed to pay Mr. Cataldo  approximately $1 million,  of which
      approximately half was to be a non-cash payment.

(3)   Represents  an option to  purchase  the number of shares  indicated  at an
      exercise  price of $0.585 per share,  the  market  price of the  Company's
      common stock on the February 18, 2004  conditional  grant date.  The grant
      was made on that date,  subject to  stockholder  approval of the Company's
      2004 Incentive Plan,  which was approved by the Company's  stockholders on
      June 22, 2004,  the effective  grant date.  The grant,  from the Company's
      2004  Incentive  Plan,  is  exercisable  for 50% of the  shares  upon  the
      effective grant date, with the remainder of the grant  exercisable on June
      22, 2005.

(4)   Represents  (i) $125,825 of  compensation  recognized  upon Mr.  Cataldo's
      exercise of 256,785  options at $0.01 per share on May 28, 2004,  when the
      market price was $0.50 per share;  and (ii) $25,000 paid in December  2004
      under the terms of the Separation and Consulting  Agreement and Release of
      Claims described in Note (2) above.

(5)   At the Company's  request,  Mr. Cataldo deferred  approximately 30% of his
      cash salary from May 2002  through  April 2003.  The figure  reported  for
      calendar  2002 is net of the deferral.  At December 31, 2002,  the Company
      had  recorded  salary  expense  totaling  approximately  $266,000  for Mr.
      Cataldo,  including an accrual of  approximately  $80,000 for his deferred
      salary. All deferred amounts due Mr. Cataldo were paid during 2003 and the
      figure  reported  for  calendar  2003  reflects  the  payment  of all such
      deferred amounts.



                                       5


(6)   On May 10,  2002,  when the market price of the Common Stock was $0.90 per
      share and pursuant to his  employment  agreement,  Mr. Cataldo was granted
      fully-vested  options  to  purchase  65,556  shares at $0.45 per share and
      options to purchase 200,000 shares at $0.90 per share,  with the option to
      purchase 100,000 shares vested  immediately and the option to purchase the
      remainder  vested on the one-year  anniversary of the option grant. In the
      fourth quarter of 2002, the Company  renegotiated  the terms of the option
      grant in Mr. Cataldo's employment  agreement,  canceling all but 30,000 of
      the options granted at $0.90. Mr. Cataldo was subsequently granted 235,556
      fully-vested  options at an exercise price of $0.32 per share,  the market
      price  of the  Common  Stock on the May 29,  2003  grant  date,  following
      stockholder approval at the May 20, 2003 Annual  Stockholders'  Meeting of
      amendments to the Company's 2000 Equity Incentive Plan.  Additionally,  on
      May 29,  2003,  Mr.  Cataldo  was  granted  fully-exercisable  options  to
      purchase  256,785  shares  at  $0.01  per  share,  in  recognition  of  an
      additional  temporary salary deferral arrangement beyond that described in
      note (5) above,  and  options to  purchase  2,000,000  shares at $0.32 per
      share.  The latter options were  exercisable 50% upon grant and 50% on the
      one year anniversary of the grant.

(7)   Dr.  George has served as  President  and Chief  Executive  Officer  since
      January 2004.  He joined the Company in January 2003 as Vice  President of
      Government Affairs.

(8)   Represents a  fully-vested  option grant for 16,827  shares at an exercise
      price of $0.01 per share in  recognition  of a temporary  salary  deferral
      arrangement  and  grants of 6,667  shares and  80,000  shares,  both at an
      exercise  price of $0.32 per share,  which  vest over a three year  period
      from the grant date.

(9)   Mr. Oyakawa served as the Company's  President and Chief Operating Officer
      and member of the Board from June 2003 to January 2004. Under the terms of
      a January 19, 2004 Separation  Agreement and Release, Mr. Oyakawa resigned
      from his positions as an officer and director of the Company  effective on
      that date. Under the terms of the agreement,  the Company paid Mr. Oyakawa
      a severance  equal to one year's salary of $350,000.  On January 15, 2004,
      when the market price of the common stock was $0.62 per share, the Company
      granted  Mr.  Oyakawa a two- year  option to  purchase  750,000  shares of
      common stock at an exercise  price of $0.32 per share.  Under the terms of
      the  grant,  the  options  became  fully  vested  upon the  signing of the
      Separation  Agreement and Release. Mr. Oyakawa may exercise the options at
      any time through January 15, 2006.

(10)  Mr.  Brounstein has served as Executive Vice President and Chief Financial
      Officer  since  joining the Company in  December  2001.  He had served the
      Company as a financial consultant from July 2001 through December 2001. He
      served as a member of the Board from December 2001 until May 2003, when he
      did not stand for re-election.

(11)  Mr.  Brounstein  was granted  25,000  fully-vested  options at an exercise
      price of $0.32 per share,  the market price of the Common Stock on the May
      29, 2003 grant date,  following  stockholder  approval at the May 20, 2003
      Annual  Stockholders'  Meeting of amendments to the Company's  2000 Equity
      Incentive Plan.  Under the terms of a January 2003  employment  agreement,
      Mr.  Brounstein was granted fully vested options to purchase 83,333 shares
      at an exercise price of $0.32 per share on May 29, 2003. Additionally,  on
      May 29, 2003,  Mr.  Brounstein  was granted  fully-exercisable  options to
      purchase  24,038 shares at $0.01 per share,  in recognition of a temporary
      salary  deferral  arrangement,  and options to purchase  625,000 shares at
      $0.32 per share.  The latter options were  exercisable  50% upon grant and
      50% on the one year anniversary of the grant.

(12)  Mr. Van Maanen has served as Vice President - Operations and International
      Business  Development  since  January 2004. He joined the Company in March
      1993 and served in various sales and marketing  management positions prior
      to his January 2004 appointment.

(13)  Represents a  fully-vested  option grant for 14,423  shares at an exercise
      price of $0.01 per share in  recognition  of a temporary  salary  deferral
      arrangement  and grants of 37,213  shares and  80,000  shares,  both at an
      exercise  price of $0.32 per share,  which  vest over a three year  period
      from the grant date.

(14)  Represents  compensation  recognized  upon Mr. Van Maanen's sale, at $1.36
      per share,  of options  exercised for 14,423 shares at $0.01 per share and
      37,213 shares at $0.32 per share in September 2003.

(15)  Represents  option grants for an aggregate of 12,570 shares,  all of which
      were cancelled in the fourth quarter of 2002.



                                       6


                     Stock Option Grants in Last Fiscal Year

                                Individual Grants

      The  following  table  sets forth  information  concerning  stock  options
granted to the Named  Executive  Officers  during the fiscal year ended December
31, 2004.  Through May 13, 2005, there have been no subsequent options grants or
other awards to the Named Executive Officers.



                                                       Percent of Total
                           Number of Securities       Options Granted  to
                                Underlying            Employees in Fiscal   Exercise Price
Name                         Options Granted               Year(1)            ($/sh)(2)      Expiration Date
- ----                         ---------------               -------            ---------      ---------------
                                                                                   
Anthony J. Cataldo (3)          5,000,000                  23.90%              0.585           5/17/2007
J. Richard George               5,000,000                  23.90%              0.585           6/22/2014
Jay Oyakawa (4)                   750,000                   3.58%              0.320(4)        1/15/2006
Richard D. Brounstein           1,500,000                   7.17%              0.585           6/22/2014
Richard R. Van Maanen           2,000,000                   9.56%              0.585           6/22/2014


- ----------

(1)   Based on the aggregate of options  granted to employees and consultants to
      the Company to purchase  18,846,000  shares under the 2004  Incentive Plan
      and 1,454,080  shares under the 2000 Equity  Incentive Plan and options to
      purchase  1,000,000  shares granted to  non-employee  Directors  under the
      Director Plan during the year ended December 31, 2004, including grants to
      the Named Executive Officers.

(2)   Except as otherwise noted, the exercise price for all option grants is the
      market price of the  Company's  common  stock on February  18,  2004,  the
      conditional  grant  date.  The  grants  were made on that date  subject to
      stockholder  approval of the  Company's  2004  Incentive  Plan,  which was
      approved by the  Company's  stockholders  on June 22, 2004,  the effective
      grant  date.  The  grant is  exercisable  for 50% of the  shares  upon the
      effective  grant  date and for the  remaining  50% of the grant on the one
      year anniversary thereof.

(3)   Under  the  terms of the  November  15,  2004  Separation  and  Consulting
      Agreement and Release of Claims between the Company and Mr.  Cataldo,  the
      Company agreed to accelerate the vesting of all his then-unvested options.
      The terms of the Separation Agreement and the option grant further provide
      that Mr.  Cataldo's  options remain  exercisable  for a period of 6 months
      following the  termination of the  consulting  arrangement on November 15,
      2006.

(4)   Pursuant to the Employment  Agreement between the Company and Mr. Oyakawa,
      on January 15, 2004,  when the market price of its common stock was $0.62,
      the Company  granted  Mr.  Oyakawa a two-year  option to purchase  750,000
      shares of common  stock at $0.32 per share.  Under the terms of the grant,
      the options became fully vested upon the signing of a Separation Agreement
      and  Release,  which was executed  between the Company and Mr.  Oyakawa on
      January 19, 2004. Mr. Oyakawa may exercise the options at any time through
      January 15, 2006.

The following table sets forth  information  concerning option exercises for the
year ended  December  31,  2004,  with  respect  to each of the Named  Executive
Officers.


                                       7



     Aggregated Option Exercises in 2004 and December 31, 2004 Option Values



                                                                                                            Value of Unexercised
                                                                      Number of Securities Underlying      n-the-Money Options at
                                    Shares                            Unexercisable Options at Fiscal       Fiscal Year End ($)
                                 Acquired on           Value                    Year End (#)                    (Exercisable/
Name                             Exercise (#)     Realized ($)(2)      (Exercisable/Unexercisable)(1)        Unexercisable)(1)(3)
- ----                             ------------     ---------------      ------------------------------        --------------------
                                                                                                     
Anthony J. Cataldo (4)                 256,785             128,393                     2,265,556 / 0                 60,684 / 0
J Richard George                             0                   0                   63,680 / 66,481              9,674 / 4,654
Jay Oyakawa (5)                              0                   0                       750,000 / 0                 52,500 / 0
Richard D. Brounstein                        0                   0                       757,371 / 0                 60,684 / 0
Richard R. Van Maanen                        0                   0                        80,000 / 0                  5,600 / 0


- ----------

(1)   Reflects  in-the-money  options  granted under the  Company's  2000 Equity
      Incentive  Plan.  None of the options  granted in 2004 from the  Company's
      2004 Incentive Plan is in-the-money at December 31, 2004.

(2)   Value realized is based on the fair market value of the shares on the date
      of exercise as reported on the  Over-The-Counter  Bulletin Board minus the
      exercise price multiplied by the number of shares acquired on exercise.

(3)   Value of unexercised in-the-money options is based on a value of $0.39 per
      share for the Company's  common  stock,  the closing price on December 31,
      2004 as quoted on the American Stock Exchange. Amounts reflect such market
      value minus the exercise  price  multiplied  by the number of shares to be
      acquired on exercise and do not indicate  that the optionee  actually sold
      such stock.

(4)   Under the terms of a November 15, 2004 Separation and Consulting Agreement
      and Release of Claims  between the  Company and Mr.  Cataldo,  the options
      continue  to vest  during the  period of the  consulting  arrangement  and
      remain  exercisable for a period of 6 months  following its termination on
      November 15, 2006.

(5)   Pursuant to the Employment  Agreement between the Company and Mr. Oyakawa,
      on January 15,  2004,  when the fair market  value of the Common Stock was
      $0.62,  the Company granted Mr. Oyakawa options to purchase 750,000 shares
      of the Common Stock at $0.32 per share.  Under the terms of the grant, the
      options became fully vested upon the signing of a Separation Agreement and
      Release, which was executed between the Company and Mr. Oyakawa on January
      19, 2004. Mr. Oyakawa may exercise the options at any time through January
      15, 2006.

                              Employment Contracts

In January 2004, the Company entered into a three year employment agreement with
Dr.  Richard  George that includes an annual salary of $250,000 and,  subject to
the approval of the Company's stockholders of the 2004 Incentive Plan, the grant
of options to purchase  5,000,000 shares of the Company's common stock. Upon the
stockholders'  approval of the 2004  Incentive Plan on June 22, 2004, the option
was  granted  with an  exercise  price of $0.585  per  share.  The  options  are
exercisable 50% upon grant and 50% on the one year  anniversary of the grant and
have a ten year term. In the event the Company  should  terminate Dr. George for
other than cause prior to the  expiration  of the  employment  agreement,  he is
entitled to the remaining payments due for the full term of the agreement.

In January 2003, the Company entered into a twelve month  employment  agreement,
with automatic  renewal  options,  with Richard  Brounstein that included a base
salary of $200,000 plus options.  Following  stockholder approval at the May 20,
2003 Annual  Stockholders'  Meeting of amendments  to the Company's  2000 Equity
Incentive  Plan, on May 29, 2003, Mr.  Brounstein was granted  fully-exercisable
options to purchase  24,038 shares of the Company's stock at $0.01 per share, in
recognition  of a salary  deferral  arrangement,  fully-exercisable  options  to
purchase  108,333 shares of the Company's  common stock at $0.32 per share,  and
options to purchase  625,000  shares of the Company's  stock at $0.32 per share.
The  latter  options  were  exercisable  50% upon  grant and 50% on the one year
anniversary of the grant.  On June 22, 2004,  upon the approval by the Company's
stockholders of the 2004 Incentive  Plan, Mr.  Brounstein was granted options to
purchase 1,500,000 shares of the Company's common stock at $0.585 per share. The
options are  exercisable  50% upon grant and 50% on the one year  anniversary of
the grant and have a ten year term.  In the event the Company  should  terminate
Mr.  Brounstein for other than cause,  he is entitled to one year's salary under
the terms of the agreement.



                                       8


Section 16(A) Beneficial Ownership Compliance

      Section 16(a) of the Exchange Act ("Section 16(a)") requires the Company's
executive  officers,  directors,  and  persons  who  own  more  than  10% of the
Company's  common  stock  (collectively,  "Reporting  Persons")  to file initial
reports of ownership and reports on changes in ownership with the Securities and
Exchange Commission (the "Commission"). Such Reporting Persons are also required
by  Commission  rules to furnish  the Company  with copies of all Section  16(a)
forms that they file. To the Company's knowledge,  based solely on the review of
copies of such reports furnished to the Company and written representations that
no other reports were required  during the fiscal year ended  December 31, 2004,
all of the Company's  Reporting  Persons  complied with all  applicable  Section
16(a) filing requirements.

Code of Business Conduct

      We have  adopted a Code of  Business  Conduct  that  applies to all of our
employees,  including our Chief Executive  Officer and Chief Financial  Officer,
and to the members of our Board of  Directors.  The Code of Business  Conduct is
posted on our website at www.calypte.com.

             COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

The  Compensation  Committee  of the  Board  of  Directors  is  responsible  for
administering the Company's executive  compensation  policies and programs.  The
Compensation  Committee  also reviews and approves the salaries and bonuses,  if
any,  of the  Company's  executive  officers  as well as all grants of long term
incentive and  equity-based  compensation  awards.  The  Compensation  Committee
currently consists of two directors,  each of whom are independent of management
and free from any  relationship  that, in the opinion of the Board of Directors,
would  interfere  with  the  exercise  of  their   independent   judgment  as  a
Compensation  Committee  member.   Further,  the  members  of  the  Compensation
Committee  are  directors  who qualify as  "non-employee  directors"  within the
meaning of Rule 16b-3 under the Securities  Exchange Act of 1934, as amended and
as  "outside  directors"  within the meaning of Section  162(m) of the  Internal
Revenue Code.

         Executive  Officer  Compensation  Policy.  The  Compensation  Committee
administers the Company's  executive  compensation  policies with the objectives
of:

o     aligning the interests of executive officers with the long-term  interests
      of  the  Company's   stockholders;

o     providing  competitive  levels of  compensation  which are, in large part,
      conditioned on the Company's  attainment of specified  performance targets
      and/or stock price appreciation; and

o     attracting,  motivating and retaining the best possible  executive  talent
      for the benefit of the Company's stockholders.

      In assessing overall compensation for executive officers, the Compensation
Committee considers the Company's performance and industry position, and general
industry  data.  In  furtherance  of these goals,  the  components  of executive
compensation are linked to both Company and individual performance.

     Employment Agreements. With the exception of the Vice President-Operations,
each Named  Executive  Officer is employed by the Company  pursuant to a written
agreement of employment.  Each employment  agreement reflects the terms that the
Compensation  Committee  believed were appropriate and/or necessary to obtain or
retain  the  services  of the  particular  executive  officer at the time it was
executed,  within the framework of the Company's  compensation  policies and its
financial condition.  The Compensation Committee has considered the advisability
of using employment  agreements and determined that under certain  circumstances
it is in the best  interests of the Company and its  stockholders  insofar as it
permits the Company to achieve its desired  goals of retaining the best possible
executive talent. In addition,  each employment  agreement contains  restrictive
covenants,  including  non-competition,   non-solicitation  and  confidentiality
covenants,  for the  benefit of the  Company.  The  Compensation  Committee  has
determined  that the use of  employment  agreements  may be necessary in certain
cases to help  ensure  the  retention  of key  executive  officers,  to  attract
additional executive talent to the Company and to impose appropriate restrictive
covenants on such officers.



                                       9


     Components  of  Executive  Compensation.   The  material  elements  of  the
Company's current executive  compensation  arrangements  include base salary and
equity  incentive  awards.  In 2004  and in  prior  years,  equity  awards  were
generally  granted in the form of options to  purchase  shares of Common  Stock.
This strategy is intended to increase the  beneficial  ownership of Common Stock
by Company executives while at the same time continuing to align their interests
with those of the Company's stockholders.

     The  Company  does  not   presently   have  a  formal  annual  bonus  plan.
Nevertheless,   subject  to  the  availability  of  sufficient  cash  resources,
executives  and certain  other key employees are eligible to earn annual cash or
stock  bonuses  for   achievement  of  both   Company-wide   and  individual  or
departmental goals.

     In 2005, the Company  expects to continue to use options to purchase Common
Stock as a primary  vehicle for equity  grants to further align the interests of
Company  employees with Company  stockholders.  The  Compensation  Committee and
Company  management  currently  view this approach as the most  appropriate  and
effective  manner of meeting the  critical  goals of  retaining  key  management
employees  and  minimizing  cash  outflows,  while at the same time aligning the
interests of key employees and stockholders. The 2004 Incentive Plan permits the
Company to issue a variety of other  equity-based  awards in  addition  to stock
options,  which the  Compensation  Committee and  management may consider in the
future.

     Base Salaries.  Base salary represents the fixed component of the executive
compensation  program.  Base  salaries  of the Chief  Executive  Officer,  Chief
Financial  Officer,   Vice   President-Operations   and  senior  management  are
determined by reviewing comparable market base salary  compensation,  individual
performance,  and relevant  experience and demonstrated  capabilities in meeting
the requirements of the position.  The Compensation Committee also evaluates the
Company's   attainment  of  its  stated   overall  goals  and  targets  and  the
individual's  contribution  toward and  performance in attaining such goals when
considering modifications to the individual's base salary.


     Long-term  Incentive Awards. As noted  previously,  the Committee  believes
that stock option  grants or other equity awards serve to align the goals of the
Company's  stockholders  and  employees.  In  addition  to that  objective,  the
Company's  equity  incentive  plan also assists the Company in  providing  (1) a
long-term incentive to help reduce employee turnover,  (2) a competitive package
for recruiting new employees, (3) a long-term reward for loyalty, dedication and
service,  and (4) the vehicle for employees to share in the rewards of "building
stockholder value."

   Executive Chairman Compensation

     In  May  2002,  in  conjunction  with a  financing  proposal  enabling  the
continuation  of  the  Company's  operations,  the  independent  members  of the
Company's  Board  entered  into a five-year  employment  agreement  with Anthony
Cataldo to serve as the Company's Executive Chairman.  The employment  agreement
specified a base  annual  salary of  $400,000  and allowed for annual  increases
based on the Company's  performance and approval of the Compensation  Committee.
The Compensation  Committee did not adjust Mr. Cataldo's base salary during 2003
or 2004.  On May 10,  2002,  when the market price of the Common Stock was $0.90
per share,  the Company  granted Mr.  Cataldo  fully-vested  options to purchase
65,556 shares of Common Stock at $0.45 per share and options to purchase 200,000
shares of Common Stock at $0.90 per share,  with the option to purchase  100,000
shares vested  immediately  and the option to purchase the remainder  vesting on
the one-year anniversary of the option grant. Both option grants had a five-year
term. In the fourth quarter of 2002, the Company  renegotiated  the terms of the
option grant contained in Mr. Cataldo's Employment Agreement,  canceling all but
30,000 of the  options  granted at $0.90.  Subsequently,  following  stockholder
approval at the May 20, 2003 Annual  Stockholders'  Meeting of amendments to the
Company's 2000 Equity  Incentive  Plan, on May 29, 2003, Mr. Cataldo was granted
235,556 fully-vested options at an exercise price of $0.32 per share, the market
price of the  Common  Stock on that date.  Additionally,  on May 29,  2003,  Mr.
Cataldo was granted  fully-exercisable  options to  purchase  256,785  shares of
Common Stock at $0.01 per share, in recognition of an additional salary deferral
arrangement,  and options to purchase  2,000,000 shares of Common Stock at $0.32
per share. The latter options were exercisable 50% upon grant and 50% on the one
year  anniversary of the grant.  Upon approval by the Company's  stockholders of
the adoption of the Company's  2004 Incentive Plan on June 22, 2004, Mr. Cataldo
was granted options to purchase  5,000,000  shares of the Company's common stock
at an  exercise  price of $0.585  per share,  the price of the  Common  Stock on
February  24,  2004,  the date the  Committee  approved  the  grant  subject  to
stockholder  approval.  The options have a ten-year term and are exercisable 50%
upon grant and 50% one year  thereafter.  On  November  15,  2004,  Mr.  Cataldo
resigned from his position as Executive Chairman and as Director of the Company.
In connection with his resignation,  the Company and Mr. Cataldo entered into an
Separation  and  Consulting  Agreement  and Release of Claims (the  "Agreement")
pursuant to which Mr.  Cataldo's  total  remuneration  is  $1,033,389,  plus the
payment of a portion of his COBRA  medical  insurance  costs.  Mr.  Cataldo will
receive a total cash  payment  of  $513,389,  payable on a monthly  basis over a
two-year period commencing on December 15, 2004, with acceleration of $75,000 in
April 2005 in conjunction with the Company's closing of a financing in excess of
$5,000,000.  Additionally, under the terms of the Agreement, on January 3, 2005,
the Company applied $520,000 to the exercise of 1,625,000 of Mr. Cataldo's stock
options  at an  exercise  price of $0.32 per share.  Mr.  Cataldo  will  provide
advisory services under the Agreement as may be requested by the Company's Chief
Executive Officer.



                                       10


     Chief  Executive   Officer,   President,   and  Chief   Operating   Officer
     Compensation

     In June 2003,  the Company  entered into a five year  employment  agreement
with Jay Oyakawa, the Company's former President and Chief Operating Officer and
member of the Board, that included an annual base salary of $350,000. On January
15, 2004,  when the market  price of the Common  Stock was $0.62 per share,  Mr.
Oyakawa was granted a two-year option to purchase 750,000 shares of Common Stock
exercisable  at $0.32  pursuant to the 2000 Plan. The option became fully vested
on January 19,  2004,  upon the  effectiveness  of a  Separation  Agreement  and
Release  between the Company and Mr.  Oyakawa.  On January 19, 2004, Mr. Oyakawa
resigned from his position as President, Chief Operating Officer and as a member
of the Board.  Under the terms of the  Separation  Agreement  and  Release,  the
Company paid Mr.  Oyakawa  severance in an amount equal to one year's  salary of
$350,000  over a twelve month period.  Mr.  Oyakawa may exercise the options for
two years from the date of grant.


     In January 2004, the Company entered into a three year employment agreement
with J. Richard  George to serve as the Company's  Chief  Executive  Officer and
President and that includes an annual base salary of $250,000.  Upon approval by
the Company's  stockholders of the adoption of the Company's 2004 Incentive Plan
on June 22, 2004, Dr. George was granted options to purchase 5,000,000 shares of
the Company's  common stock at an exercise price of $0.585 per share,  the price
of the Common Stock on February 24, 2004,  the date the  Committee  approved the
grant subject to stockholder approval.  The options have a ten-year term and are
exercisable 50% upon grant and 50% one year thereafter. Effective April 1, 2005,
the  Compensation  Committee  approved an increase in Dr.  George's  annual base
salary  to  $350,000.   The  Compensation  Committee  considers  this  level  of
compensation  appropriate  in view of Dr.  George's  background,  leadership and
accomplishments.

     Chief Financial Officer Compensation

     On January 1, 2003,  the Company  entered  into a twelve  month  employment
agreement,  with automatic  renewal  options,  with Richard D.  Brounstein,  the
Company's Executive Vice President and Chief Financial Officer, that included an
annual  base  salary  of  $200,000,  which  has  not  been  adjusted  since  the
commencement of the employment agreement. The employment agreement also included
the grant of options to purchase  83,333  shares of Common  Stock at an exercise
price of $1.50 per share,  subject to stockholder  approval of amendments at the
2003 Annual Meeting of Stockholders to the Company's 2000 Equity Incentive Plan.
The options  granted  were to be fully  vested on the grant date.  In the fourth
quarter of 2002, Mr. Brounstein  permitted the Company to cancel the outstanding
options previously granted to him. Subsequently,  following stockholder approval
at the May 20, 2003 Annual Stockholders' Meeting of amendments to the 2000 Plan,
on May 29, 2003 Mr.  Brounstein  was granted 25,000  fully-vested  options at an
exercise price of $0.32 per share,  the market price of the Common Stock on that
date. The options granted  conditionally to Mr.  Brounstein under his Employment
Agreement  were also granted as fully vested at $0.32 per share on May 29, 2003.
Additionally,  on May 29, 2003,  Mr.  Brounstein  was granted  fully-exercisable
options  to  purchase  24,038  shares of Common  Stock at $0.01  per  share,  in
recognition of an earlier temporary salary deferral arrangement,  and options to
purchase  625,000 shares of Common Stock at $0.32 per share.  The latter options
were  exercisable  50% upon  grant  and 50% on the one year  anniversary  of the
grant.  Upon  approval  by the  Company's  stockholders  of the  adoption of the
Company's  2004  Incentive  Plan on June 22, 2004,  Mr.  Brounstein  was granted
options  to  purchase  1,500,000  shares  of the  Company's  common  stock at an
exercise  price of $0.585 per share,  the price of the Common  Stock on February
24,  2004,  the date the  Committee  approved the grant  subject to  stockholder
approval.  The options have a ten-year term and are  exercisable  50% upon grant
and 50% one year thereafter.  The Committee considers this level of compensation
appropriate   in   view  of  Mr.   Brounstein's   background,   leadership   and
accomplishments.



                                       11


     Vice-President - Operations Compensation

     In  January  2004,  the  Company   appointed  Mr.  Richard  Van  Maanen  as
Vice-President  Operations and International  Business  Development at an annual
base  salary of  $200,000.  Mr. Van Maanen has been an  employee  of the Company
since 1993 in a variety of marketing  and sales  positions.  The Company has not
entered into an employment  contract  with Mr. Van Maanen.  Upon approval by the
Company's  stockholders  of the adoption of the Company's 2004 Incentive Plan on
June 22, 2004, Mr. Van Maanen was granted options to purchase  2,000,000  shares
of the  Company's  common  stock at an exercise  price of $0.585 per share,  the
price of the Common Stock on February 24, 2004, the date the Committee  approved
the grant subject to stockholder approval.  The options have a ten-year term and
are  exercisable  50% upon  grant  and 50% one year  thereafter.  The  Committee
considers  this level of  compensation  appropriate  in view of Mr. Van Maanen's
background, leadership and accomplishments.

              SUBMITTED BY THE COMPENSATION COMMITTEE OF THE BOARD


                                               Julius R. Krevans, M.D., Chairman
                                               Paul E. Freiman

April 28, 2005

Compensation Committee Interlocks and Insider Participation

During 2004, the Compensation  Committee consisted of Dr. Julius Krevans and Mr.
Paul  Freiman,  each  of whom  is a  non-employee  director.  No  member  of the
Compensation  Committee has a relationship that would constitute an interlocking
relationship with executive officers or directors of another entity.


                            REPORT OF AUDIT COMMITTEE

The following  report of the Audit Committee of the Board shall not be deemed to
be incorporated by reference by any general statement incorporating by reference
this Proxy  Statement into any filing by the Company under either the Securities
Act of 1933,  as amended,  or the  Exchange  Act,  except to the extent that the
Company specifically  incorporates this information by reference.  The following
report shall not otherwise be deemed filed under such Acts.

         The  role  of  the Audit  Committee (the  "Committee") is to assist the
Board in its  oversight of the integrity of the  Company's  financial  reporting
process,  the Company's compliance with legal and regulatory  requirements,  and
the Company's independent registered public accounting firm's qualifications and
independence.  The Audit Committee  operates pursuant to a Charter that was last
amended and  restated  by the Board on March 7, 2005 and is  included  herein as
Appendix C. At December  31, 2004,  the Audit  Committee  consisted  of: Paul E.
Freiman  (Chairman),  John J. DiPietro and Julius R. Krevans,  M.D. Dr.  Krevans
replaced  Zafar I.  Randawa,  Ph.D.,  who  resigned  as a member of the Board of
Directors  effective June 30, 2004. Each Audit  Committee  member is financially
literate under  applicable  American Stock Exchange listing  standards,  and Mr.
Freiman and Mr. DiPietro also are "audit committee financial experts" as defined
by the SEC.  All members of the Audit  Committee  also meet the audit  committee
independence requirements under the SEC and AMEX rules.

         Management  of  the  Company  is  responsible   for  the   preparation,
presentation and integrity of the Company's financial statements,  the Company's
accounting  and  financial  reporting   principles  and  internal  controls  and
procedures   designed  to  assure  compliance  with  accounting   standards  and
applicable laws and regulations.  The independent  registered  public accounting
firm  is  responsible  for  auditing  the  Company's  financial  statements  and
expressing  an  opinion  as  to  their  conformity  with  accounting  principles
generally accepted in the United States of America ("GAAP").


                                       12


         In the  performance  of its oversight  function,  the Committee met and
held  discussions  with  management  and  Odenberg  Ullakko  Muranishi & Co. LLP
("OUM"), the Company's independent registered public accounting firm. Management
represented to the Committee that the Company's audited  consolidated  financial
statements for the year ended December 31, 2004 were prepared in accordance with
GAAP,  and the  Committee  reviewed and  discussed  the  consolidated  financial
statements  for the year ended  December 31, 2004 with  management and with OUM.
The Committee also  discussed  with OUM the matters  required to be discussed by
Statement on Auditing  Standards No. 61,  Codification of Statements on Auditing
Standards, as modified or supplemented.

         In addition,  the Committee  discussed with OUM their independence from
the Company and its  management,  and OUM provided to the  Committee the written
disclosures  and  letter  required  from  the  independent   registered   public
accounting firm by the Independence Standards Board Standard No. 1 (Independence
Discussions with Audit Committees) as modified or supplemented.

         The  Committee  discussed  with the OUM the overall scope and plans for
their audit. The Committee met with OUM, with and without management present, to
discuss the results of their  examination,  their  evaluations  of the Company's
internal controls, and the overall quality of the Company's financial reporting.

         The  members of the  Committee  are not  professionally  engaged in the
practice of auditing and therefore rely without independent  verification on the
information  provided to them and on the representations  made by management and
the report of the independent registered public accounting firm Accordingly, the
Audit  Committee's  oversight does not provide an independent basis to determine
that management has maintained  appropriate  accounting and financial  reporting
principles or appropriate  internal  controls and procedures  designed to assure
compliance  with  accounting  standards  and  applicable  laws and  regulations.
Furthermore,  the Audit Committee's reviews and discussions referred to above do
not assure that the audit of the Company's financial statements has been carried
out in accordance with generally accepted auditing standards, that the financial
statements are presented in accordance with GAAP or that the Company's  auditors
are in fact  "independent."  The Audit Committee's  responsibility is to monitor
and review  these  processes,  acting in an  oversight  capacity,  and the Audit
Committee  does not certify the  financial  statements,  internal  control  over
financial  reporting or guarantee the independent  registered  public accounting
firm's reports.

         Based upon the reports and  discussions  described in this report,  and
subject to the  limitations  on the role and  responsibilities  of the Committee
referred  to  above  and  in  the  Audit  Committee's   Charter,  the  Committee
recommended  to the Board of Directors  the  inclusion of the audited  financial
statements  in the  Company's  Annual  Report on Form  10-KSB and Form  10-KSB/A
(No.1) for the year ended December 31, 2004 for filing with the SEC.

         The  Committee has  recommended  and the Board has appointed OUM as the
Company's  independent  registered  public  accounting  firm for the fiscal year
ending  December  31,  2005.  The Audit  Committee  and the Board  request  that
stockholders ratify such appointment.

                  SUBMITTED BY THE AUDIT COMMITTEE OF THE BOARD

                                                     Paul E. Freiman, Chairman
                                                     John J. DiPietro
                                                     Julius R. Krevans, M.D.

April 28, 2005


         Changes  in  and  Disagreements  with  Accountants  on  Accounting  and
Financial Disclosure

         On December 23, 2003, we dismissed KPMG LLP ("KPMG") as our independent
auditor.  During 2003, KPMG's report on our financial statements did not contain
an adverse  opinion or disclaimer of opinion or  modification as to uncertainty,
audit  scope  or  accounting  principles.  The  decision  to  dismiss  KPMG  was
recommended by the Audit  Committee.  We had a disagreement  with KPMG regarding
whether  conditions  necessary  for KPMG to  complete  its review of our interim
financial  statements  contained in our Quarterly  Report on Form 10-QSB for the
period ended  September 30, 2003 and to audit our financial  statements  for our
fiscal year ended  December 31, 2003 had been  satisfied.  The subject matter of
the  disagreement  regarded  whether KPMG believed that the Audit  Committee had
adequately  conducted an  investigation  of the matters  reported in an informal
inquiry  initiated by the SEC and had taken appropriate  remedial  actions.  The
Audit Committee and its outside counsel  discussed with KPMG the findings of the
Audit Committee's  investigation into the informal inquiry matters and the Audit
Committee's  recommended  remedial  actions.  The  Audit  Committee,   with  the
assistance  of its  outside  counsel,  unsuccessfully  attempted  to resolve the
disagreement with KPMG.

         Subsequently,  by letter  dated  July 14,  2004,  the SEC  Division  of
Enforcement  notified  us that  the  matter  has  been  terminated  and  that no
enforcement action has been recommended by the Commission at this time.

         On December 24, 2003, upon approval of the Audit Committee,  we engaged
Odenberg Ullakko Muranishi & Co. LLP ("OUM") to audit our consolidated financial
statements  for each of the two years  ending  December 31, 2003 and 2002 and to
review our interim financial statements contained in the our Quarterly Report on
Form 10-QSB for the quarterly  period ended  September 30, 2003.  During our two
most recent fiscal years prior to 2003 and through December 24, 2003, we had not
consulted with OUM regarding either (i) the application of accounting principles
to a specified  transaction,  either completed or proposed; or the type of audit
opinion  that might be  rendered  on our  financial  statements,  and  neither a
written report nor oral advice was provided that was an important factor that we
considered  in reaching a decision as to the  accounting,  auditing or financial
reporting  issue;  or  (ii)  any  matter  that  was  either  the  subject  of  a
disagreement, as that term is defined in Item 304(a)(1)(iv)(A) of Regulation S-B
and the related instructions to Item 304 of Regulation S-B.

         We provided  OUM with a copy of the  disclosures  contained in our Form
8-K, Item 4 filings and provided OUM with an  opportunity to furnish us a letter
addressed  to the SEC  containing  any  new  information,  clarification  of our
expression  of our views,  or the  respects  in which it does not agree with the
statements  we have made herein.  OUM has advised us that it has reviewed  these
filings  and has no basis on which to  submit a letter  addressed  to the SEC in
response to Item 304(a) of Regulation S-B.


                    RELATIONSHIP WITH INDEPENDENT ACCOUNTANTS


         Odenberg  Ullakko  Muranishi  & Co.  LLP  ("OUM")  is  the  independent
registered  public   accounting  firm  that  audited  the  Company's   financial
statements for the years ended  December 31, 2004 and 2003. The Audit  Committee
first  engaged OUM in December  2003.  OUM performed no services for the Company
during  calendar 2003, but performed  audit and review  services for 2003 during
calendar  2004.  The aggregate fees billed during 2004 for each of the following
categories of services are set forth below:

                                                   2004          2003 and 2002
                                                 --------        -------------
         Audit fees                              $191,280            $ 135,000
         Audit-related fees                      $ 29,447                   --
         Tax fees                                      --                   --
         All other fees                                --                   --



                                       13


         "Audit  fees"  include  fees  invoiced  in 2004 for the  audits  of the
Company's annual financial  statements for 2004, 2003 and 2002 and the quarterly
review of the statements for the quarters ended March 31, June 30, and September
30, 2004,  and  September  30, 2003 as well as fees for  consultation  regarding
accounting issues and their impact on or presentation in the Company's financial
statements.  "Audit-related  services"  consists  primarily  of  the  review  of
registration statements and the issuance of related consents. "Tax fees" include
tax planning and the  preparation  of the  Company's  tax returns.  OUM does not
provide  any tax or  financial  information  systems  design  or  implementation
services to the Company.

         Since the  engagement  of OUM in December 2003, the Audit Committee has
pre-approved all audit and permissible non-audit services provided by OUM.

         The following table  summarizes fees billed for services during 2003 by
KPMG LLP, the Company's former auditors, for each of the following categories of
service:

                                                               2003
                                                             --------
                      Audit fees                             $108,450
                      Audit-related fees                     $ 62,075
                      Tax fees                                     --
                      All other fees                         $ 53,365

         "Audit  fees"  include  fees  invoiced  in 2003  for the  audit  of the
Company's annual financial  statements for 2002 and the quarterly reviews of the
statements  for calendar  2003 through  September  30, 2003, as well as fees for
consultation  regarding accounting issues and their impact on or presentation in
the Company's financial statements. "Audit-related services" consisted primarily
of the review of registration  statements and the issuance of related  consents.
"Tax fees"  include  tax  planning  and the  preparation  of the  Company's  tax
returns. KPMG did not provide any tax or financial information systems design or
implementation  services to the Company. "All other fees" represents fees billed
during  the  fourth  quarter  of  2003  in  connection  with  KPMG's  review  of
documentation  supplied by the Company to the Audit Committee's  outside counsel
related to the SEC's informal  inquiry  described in Part I, Item 8 of this Form
10-KSB/A (No.1).

Certain Relationships and Related Transactions

In August  2001,  the  Company  issued a $400,000  8.5%  Promissory  Note to LHC
Corporation,  the parent company of its  then-largest  stockholder.  The Company
renegotiated  the note during 2001,  2002 and  subsequently in 2003. The Company
repaid the note in 2003.  In  November  2003,  the Company  entered  into a Note
Purchase Agreement with Marr Technologies, BV ("Marr"), its largest stockholder,
that it subsequently modifed during 2004. The Company issued no notes under this
facility prior to its December 31, 2004 expiration.


In  connection  with Marr's  purchase  of an  aggregate  of $2.5  million of the
Company's  common  stock  during  2003,  the  Company  signed  a  Memorandum  Of
Understanding  to  create a joint  venture  with  Marr in China  to  market  the
Company's current and future products. Additionally, the Nominating Committee of
the Company's Board of Directors  agreed to grant Marr the right to nominate two
mutually-agreeable  representatives to the Company's Board of Directors.  During
2004, Roger I. Gale and Maxim A. Soulimov,  who were both initially nominated by
Marr, were added to the Company's Board of Directors.


In November 2003, the Company formed a joint venture, Beijing Calypte Biomedical
Technology Ltd., with Marr Technologies  Limited, an affiliate of Marr, in which
the Company owns 51% of the stock.


                                       14



                             STOCK PERFORMANCE CHART


      The graph below compares the cumulative  total  stockholder  return on the
Common  Stock  assuming  an  initial   investment  on  December  31,  1999.  The
Corporation's  return is shown with the cumulative  total return of the American
Stock Exchange Market Value (U.S.) Index, the NASDAQ Stock  Market--U.S.  Index,
the American  Stock Exchange  Health  Products and Services Index and the Nasdaq
Biotechnology  Index.  The graph assumes a $100 investment made at the beginning
of the respective period and reinvestment of all dividends.


                  COMPARISON OF 5 YEAR CUMULATIVE TOTAL RETURN*

       AMONG CALYPTE BIOMEDICAL CORPORATION, THE NASDAQ STOCK MARKET (U.S)
     INDEX, THE AMERICAN STOCK EXCHANGE MARKET VALUE (U.S) INDEX, THE NASDAQ
       BIOTECHNOLOGY INDEX AND THE AMEX HEALTH PRODUCTS AND SERVICES INDEX

         [TABLE BELOW REPRESENTS A LINE CHART IN THE ORIGINAL DOCUMENT]

                                            Cumulative Total Return ($)
                                 -----------------------------------------------
                                 12/99   12/00   12/01   12/02   12/03    12/04

CALYPTE BIOMEDICAL CORPORATION   100.00   74.47   13.16    3.84    1.10     0.92
NASDAQ STOCK MARKET (U.S.)       100.00   60.30   45.49   26.40   38.36    40.51
AMEX MARKET VALUE (U.S.)         100.00   77.40   68.68   58.74   83.47   102.61
NASDAQ BIOTECHNOLOGY             100.00  153.84  124.26   69.11   96.95   100.60
AMEX HEALTH PRODUCTS & SERVICES  100.00  147.36  111.91   66.33  115.24   115.15

*   $100 invested on 12/31/99 in stock or index - including reinvestment of
    dividends. Fiscal year ending December 31.



                                       15


         Security Ownership of Certain Beneficial Owners and Management


      Except as set forth in the footnotes to this table,  the  following  table
sets forth  information  known to the  Company  with  respect to the  beneficial
ownership  of its common  stock as of May 13, 2005 for (i) all persons  known by
the Company to own  beneficially  more than 5% of its outstanding  Common Stock,
(ii) each of the Company's  directors,  (iii) each Named  Executive  Officer and
(iv) all directors and executive officers of the Company as a group.



                                                                                    Shares
                                                                                 Beneficially      % of
                5% Stockholders, Directors and Officers (1)                         Owned        Total (2)
                -------------------------------------------                         -----        ---------
                                                                                              
Marr Technologies BV (3)                                                          59,062,225        32.12
   Strawinskylaan 1431
   1077XX, Amsterdam
   The Netherlands
SF Capital Partners Ltd. (4)                                                      18,050,000         9.99
    3600 South Lake Drive
    St. Francis, WI 53235
Roger I. Gale (5)                                                                  1,215,000            *
J. Richard George (6)                                                              5,075,717         2.88
Richard D. Brounstein  (7)                                                         2,257,371         1.30
John J. DiPietro (8)                                                                 307,977            *
Paul E. Freiman (9)                                                                  309,901            *
Julius Krevans, M.D.(10)                                                             308,468            *
Maxim A. Soulimov (11)                                                               200,000            *
Richard R. Van Maanen (12)                                                         2,053,589         1.19

All current directors and executive officers as a group (8 persons)               11,728,023         6.42


- ----------

*     Represents beneficial ownership of less than 1%.

(1)   To the Company's  knowledge,  except as set forth in the footnotes to this
      table and subject to applicable community property laws, each person named
      in this table has sole  voting and  investment  power with  respect to the
      shares  set  forth  opposite  such  person's  name.  Except  as  otherwise
      indicated, the address of each of the persons in this table is as follows:
      c/o  Calypte  Biomedical  Corporation,   5000  Hopyard  Road,  Suite  480,
      Pleasanton, California 94588.

(2)   Based on 171,243,303 shares outstanding as of May 13, 2005.

(3)   Marat  Safin has voting and  investment  control  over shares held by Marr
      Technologies BV. Based on holdings reported in Amendment No. 4 to Schedule
      13D dated August 9, 2004 filed with the Securities and Exchange Commission
      plus 9,333,333  shares  subject to Secured 8%  Convertible  Notes that are
      immediately convertible,  3,125,000 shares subject to warrants exercisable
      within 60 days and 188,741 shares  underlying  convertible  notes issuable
      within  60  days in  payment  of  interest  on the 8%  Convertible  Notes.
      Excludes  14,033,333  shares  underlying  warrants not  exercisable  until
      October 4, 2005.

(4)   Michael A. Roth and Brian J. Stark possess  voting and  dispositive  power
      over all of the  shares  owned by SF Capital  Partners  Ltd.  This  number
      includes  8,632,324  shares of common stock and 3,500,000 shares of common
      stock issuable upon exercise of warrants  acquired in our May 2004 private
      placement. Under the terms of the Secured 8% Senior Convertible Notes (the
      "Notes") and warrants ("Warrants") acquired by SF Capital Partners Ltd. in
      April 2005, SF Capital may convert the Notes into 13,333,333 shares of our
      common  stock  and the  Warrants  may be  exercised  for the  purchase  of
      19,333,333  shares of our common stock.  The Warrants are not  exercisable
      prior to October 4, 2005 and, accordingly, are excluded from the number of
      shares reported as beneficially  owned.  The Notes are convertible only to
      the extent that the number of shares of common stock issuable  pursuant to
      the Notes or Warrants,  together with the number of shares of common stock
      owned by SF Capital (but not including  shares of common stock  underlying
      unconverted portions of the Notes or unexercised portions of the Warrants)
      would not exceed 9.999% of the then-outstanding common stock as determined
      in accordance  with Section 13(d) of the Exchange  Act.  Accordingly,  the
      number of shares of stock  shown as  beneficially  owned by SF  Capital is
      limited  to 9.999%  of the  then-outstanding  shares.  In the  absence  of
      ownership limitations, SF Capital would beneficially own 25,735,287 shares
      or 13.66%,  including 269,630 shares underlying convertible notes issuable
      in   payment  of   interest   on  the  Notes   within  60  days,   of  our
      then-outstanding  common stock as determined  in  accordance  with Section
      13(d) of the Exchange Act.


                                       16


(5)   Includes  1,050,000 shares subject to options  exercisable within 60 days.
      Marr  Technologies BV ("Marr"),  the beneficial owner of 58,873,484 shares
      of Calypte  Common  stock (the "Marr  Holdings")  was granted the right to
      nominate two (2)  mutually-agreeable  candidates  for  appointment  to the
      Calypte Board of Directors pursuant to an August 2003 agreement.  Mr. Gale
      was nominated by Marr and subsequently appointed as a Director on November
      15,  2004 upon the  recommendation  of the  Nominating  Committee  and the
      approval of the Calypte Board of Directors.  Mr. Gale disclaims any direct
      or indirect  beneficial  ownership of Marr  Holdings and does not exercise
      any control nor does he take part in any investment  decisions  undertaken
      by Marr and does not have a direct or indirect  pecuniary interest in Marr
      Holdings.

(6)   Includes 5,075,717 shares subject to options exercisable within 60 days.

(7)   Includes 2,257,371 shares subject to options exercisable within 60 days.

(8)   Includes 307,734 shares subject to options exercisable within 60 days.

(9)   Includes 309,901 shares subject to options exercisable within 60 days.

(10)  Includes 308,001 shares subject to options exercisable within 60 days.

(11)  Includes  200,000  shares subject to options  exercisable  within 60 days.
      Marr  Technologies BV ("Marr"),  the beneficial owner of 58,873,484 shares
      of Calypte  Common  stock (the "Marr  Holdings")  was granted the right to
      nominate two (2) mutually  agreeable  candidates  for  appointment  to the
      Calypte  Board of  Directors  pursuant  to an August 2003  agreement.  Mr.
      Soulimov was nominated by Marr and subsequently appointed as a director on
      April 2, 2004 upon the recommendation of the Nominating  Committee and the
      approval  of the  Calypte  Board  of  Directors.  He was  re-elected  as a
      Director  at the annual  Meeting of  Stockholders  on June 22,  2004.  Mr.
      Soulimov  disclaims  any direct or indirect  beneficial  ownership of Marr
      Holdings  and does not  exercise  any control nor does he take part in any
      investment  decisions  undertaken  by Marr and  does not have a direct  or
      indirect pecuniary interest in Marr Holdings.

(12)  Includes 2,053,334 shares subject to options exercisable within 60 days.


Compliance with Section 16(a) of the Exchange Act

      Section 16(a) of the Exchange Act ("Section 16(a)") requires the Company's
executive  officers,  directors,  and  persons  who  own  more  than  10% of the
Company's  common  stock  (collectively,  "Reporting  Persons")  to file initial
reports of ownership and reports on changes in ownership with the Securities and
Exchange Commission (the "Commission"). Such Reporting Persons are also required
by  Commission  rules to furnish  the Company  with copies of all Section  16(a)
forms that they file. To the Company's knowledge,  based solely on the review of
copies of such reports furnished to the Company and written representations that
no other reports were required  during the fiscal year ended  December 31, 2004,
all of the Company's  Reporting  Persons  complied with all  applicable  Section
16(a) filing requirements.

Code of Business Conduct

      We have  adopted a Code of  Business  Conduct  that  applies to all of our
employees,  including our Chief Executive  Officer and Chief Financial  Officer,
and to the members of our Board of  Directors.  The Code of Business  Conduct is
posted on our website at www.calypte.com.


                                       17



 PROPOSAL TO APPROVE THE ISSUANCE OF SHARES OF COMMON STOCK IN EXCESS OF 19.99%
  OF THE OUTSTANDING COMMON STOCK AND PRICE ADJUSTMENTS IN CONNECTION WITH OUR
                    APRIL 2005 ISSUANCE OF NOTES AND WARRANTS
                                  (Proposal 2)

On April 4, 2005, in order to meet our need for additional  working capital,  we
entered  into  a  Purchase  Agreement  dated  as of  that  date  (the  "Purchase
Agreement")  pursuant to which we concluded a private placement (the "April 2005
Placement") to five institutional investors (the "2005 Investors") of $8,000,000
million in aggregate principal amount of our Secured 8% Senior Convertible Notes
due on April 3, 2007 (the "Notes"). The Notes are convertible at $0.30 per Share
(the "Conversion Price") into 26,666,667 shares (the "Conversion Shares") of our
Common Stock, par value $0.03 per share ("Common Stock" or "Shares"), subject to
anti-dilution adjustments (discussed more specifically below). The Notes provide
for interest to be paid in cash or, subject to certain conditions,  by accreting
the interest to principal (the "Notes Interest  Provision"),  increasing thereby
the number of Shares into which the Notes are convertible.

We also issued to the 2005 Investors in the April 2005 Placement Series A Common
Stock  purchase  warrants  (the "Series A  Warrants")  and Series B Common Stock
purchase warrants (the "Series B Warrants"), each expiring on April 3, 2010. The
Series A Warrants are exercisable to purchase  26,666,667 shares of Common Stock
at $0.325 per Share (the "Series A Warrant  Shares").  The Series B Warrants are
exercisable  to purchase  12,000,000  shares of Common Stock at $0.325 per Share
(the  "Series B Warrant  Shares").  The terms of the Series A  Warrants  and the
Series B Warrants  provide  that they  cannot be  exercised  prior to six months
after their issue date. The Series A Warrants and the Series B Warrants  provide
for  anti-dilution and other adjustments of Series A Warrant Shares and Series B
Warrant Shares and the exercise prices thereof.

In  consideration  of  financial  advisory  services  rendered  prior  to and in
connection  with the April 2005  Placement,  and pursuant to our agreements with
two agents,  we issued to those  agents,  cumulatively,  (i)  $97,500  principal
amount of Notes;  (ii) Series A Warrants to  purchase  325,000  Series A Warrant
Shares and Series B Warrants to purchase  146,250 Series B Warrant  Shares;  and
(iii) Series A Warrants, modified to remove anti-dilution rights (the "Agent Fee
Warrants"),  to purchase  533,333 Series A Warrant Shares at $0.30 per Share and
1,333,333  Series A Warrant  Shares at $0.23  per  Share  (the  Series A Warrant
Shares  issuable  upon  exercise of the Agent Fee Warrants are called the "Agent
Fee Warrant Shares").

If, without regard to any  anti-dilution  or other  adjustments,  the Notes were
converted in full and the Series A Warrants, Series B Warrants and the Agent Fee
Warrants  were  exercised  in full,  we would be  required  to issue  67,996,250
Shares,  which is equal to 39.7% of our  Common  Stock  outstanding  on April 4,
2005. Our Shares trade on the American Stock Exchange  ("AMEX").  As a result of
AMEX Rule 713 and the  agreement we entered into with AMEX as a condition to the
listing  of our  Shares  on AMEX,  we are  required  to obtain  approval  of our
stockholders  before issuing or becoming  required to issue any shares in excess
of 19.99% of our outstanding  Common Stock, which was 34,224,397 Shares on April
4, 2005. Due to the urgency of our need to obtain additional  working capital in
early 2005, we entered into the April 2005 Placement before seeking  stockholder
approval of the issuance of Shares in excess of 19.99% of our Common  Stock.  In
order to comply with AMEX requirements  applicable to us, the 2005 Investors and
we agreed to  structure  the  April  2005  Placement  to make  subject  to prior
approval by our  stockholders  the  effectiveness of any provisions of the April
2005  Placement  that  would  cause more than  19.99% of our Common  Stock to be
issued.  Doing so  enabled us to  complete  the April  2005  Placement  prior to
obtaining such stockholder approval without violating AMEX's requirements.


                                       18


We are  required  pursuant to the AMEX  requirements  and the terms of the April
2005  Placement to obtain the  approval of our  stockholders  before  issuing or
becoming  required  to issue  any  Shares in  excess  of the  34,224,397  Shares
constituting  19.99% of our  outstanding  Common  Stock on April 4,  2005.  Such
issuance above 19.99% of our  outstanding  Common Stock on April 4, 2005,  could
occur upon:

      o     the  effectiveness  of the  anti-dilution  provisions  of the  Notes
            pursuant to which the number of Conversion  Shares issuable could be
            increased as a result of our  issuance  within one year of the issue
            date of the Notes any Common Stock or Common Stock equivalents for a
            price less than the Conversion Price, thereby causing the Conversion
            Price to be reduced  to be equal to the price of the new  securities
            issued (the "Notes Anti-dilution Adjustments"); and

      o     the  effectiveness  of the  anti-dilution  provision of the Series A
            Warrants  (but not the Series B Warrants or the Agent Fee  Warrants)
            pursuant to which, within one year of the issue date of the Series A
            Warrants,  the  exercise  price of the  Series A  Warrants  could be
            reduced to be equal to the price of any Common Stock or Common Stock
            equivalents we issue for a price less than the exercise price of the
            Series  A   Warrants   (the   "Series   A   Warrants   Anti-dilution
            Adjustment").

The  April  2005  Placement   transaction   documents  provide  that  the  Notes
Anti-dilution  Adjustments  and the Series A Warrants  Anti-dilution  Adjustment
will not become effective unless our stockholders approve them.

If,  prior  to  obtaining   stockholder   approval  of  Proposal  2,  the  Notes
Anti-dilution  Adjustments  were to become  effective  or the  Series A Warrants
Anti-dilution Adjustment were to become effective, we would not be in compliance
with the AMEX rules and would violate our listing  agreement with AMEX, with the
result that our Shares would be subject to delisting by AMEX. A delisting of our
Shares from AMEX would likely have a material adverse effect on the market value
of our Shares and would  materially  impair the ability of our  stockholders  to
sell their Shares.  To avoid that result,  we agreed with the 2005  Investors in
the April 2005 Placement to seek stockholder approval for the potential issuance
of Shares in excess of the  34,224,397  Shares  described  above pursuant to the
Notes  Anti-dilution   Adjustments  and  the  Series  A  Warrants  Anti-dilution
Adjustment. We have made Proposal 2 in order to fulfill our obligation under the
Purchase Agreement to seek stockholder  approval of such potential issuances and
adjustments.  Pending such approval, the Notes Anti-dilution Adjustments and the
Series A Warrants Anti-dilution Adjustment cannot be effected.

Proposal 2 requests our  stockholders to approve the issuance of Shares pursuant
to the April  2005  Placement  in excess  of 19.99% of our  Common  Stock and to
approve the potential  reduction of the  Conversion  Price pursuant to the Notes
Anti-dilution  Adjustments  and the  exercise  price of the  Series  A  Warrants
pursuant  to the  Series  A  Warrants  Anti-dilution  Adjustment.  Our  Board of
Directors recommends that stockholders vote FOR Proposal 2.


                                       19


Description of the Notes

The form of the Notes was filed as Exhibit 10.157 to our Form 8-K filed on April
5, 2005. The principal terms of the Notes are summarized below:

Maturity, Interest,  Conversion. The Notes will mature on the second anniversary
of the date of their issuance and bear interest at the rate of 8% per annum.  We
will pay  interest  on a  quarterly  basis,  either in cash or, if Proposal 2 is
approved by the stockholders and as long as we satisfy the applicable conditions
set forth in the Notes,  pursuant to the Notes  Interest  Provision by accreting
interest to the principal amount due under the Notes.

Security,  Priority,  Ranking.  Pursuant to a Security  Agreement (the "Security
Agreement")  entered into  concurrently with the Notes, the Notes are secured by
all of our assets, except certain equipment that we currently own or may acquire
in the future that is (or will be) subject to separate  purchase  money security
interests.  The Notes rank at least pari passu in right of payment  with all our
other indebtedness.

Certain  Covenants.  The Purchase  Agreement and the Security  Agreement contain
covenants and events of default that are customary for high-yield  senior notes.
The Security  Agreement  provides  for: (1)  limitations  on our ability and the
ability of our subsidiaries to incur or guarantee indebtedness;  (2) limitations
on dividends and other payments to holders of equity and subordinated  debt; (3)
limitations on investments;  (4) limitations on sale and leaseback transactions;
(5) limitations on asset sales,  consolidations and mergers;  (6) limitations on
creating or assuming liens; and (7) limitations on transactions with affiliates.
These  provisions  have  certain   exceptions,   minimums  and  carve-outs.   In
particular, the limitation on incurrence of indebtedness permits us to incur (i)
up to  $3,000,000  in  additional  unsecured  debt;  (ii)  up  to an  additional
$3,000,000  in  purchase  money  debt  obligations;   (iii)  unsecured  debt  in
connection  with a  $5,500,000  credit  facility  with  Marr  Technologies  B.V.
("Marr");   and  (iv)  up  to  $5,000,000  in  debt   associated   with  foreign
subsidiaries.

Conversion;  Participation  Rights.  The  holders of the Notes have the right to
convert their Notes into Shares at any time on or prior to their  maturity date.
Any Note that is not  converted  into Shares prior to the maturity  date will be
repaid on the maturity date.


                                       20


The number of Shares to be issued upon  conversion of the Notes is determined by
dividing the  principal  amount to be converted  (together  with any accrued but
unpaid interest on such principal  amount) by the Conversion  Price. The initial
Conversion Price is $0.30. Assuming that all the Notes are converted into Shares
on the maturity date at the Conversion  Price, the Notes  (excluding  Conversion
Shares  issued  pursuant to the Notes  Interest  Provision)  will  convert  into
26,991,667 Conversion Shares. Assuming that all interest due on the Notes on the
maturity date is paid by accretion to principal  pursuant to the Notes  Interest
Provision, the interest would be converted into 4,702,335 Conversion Shares. The
Notes contain customary provisions for the adjustment of the Conversion Price in
the event that we declare a stock  dividend or stock split or any tender  offer,
merger, consolidation, recapitalization, reorganization or similar transaction.

In addition,  provided the stockholders  approve Proposal 2, if we issue or sell
Shares or any security  convertible or exchangeable  into Shares within one year
of the  issue  date of the  Notes at a price  per  Share  that is less  than the
Conversion  Price on the issue date of the Notes,  the Conversion Price shall be
reduced,  pursuant to the Notes Anti-dilution  Adjustments,  to be equal to such
lower price.  Applicability of the Notes Anti-Dilution Adjustments is subject to
exclusions  for  issuances  related  to  prior  transactions  and  issuances  to
employees  and   consultants,   and  issuances  in  connection   with  strategic
transactions and capital leases. For example,  if, within one year from April 4,
2005,  we raise  additional  funds by  issuing  Shares  for a price of $0.21 per
Share, the Conversion Price would be decreased from $0.30 per share to $0.21 per
share and we would be  required  to issue  11,567,857  additional  Shares if the
Notes were fully converted.

In  addition  to the Notes  Anti-Dilution  Adjustments,  if we issue  additional
Common Stock or Common Stock equivalents within one year of the issue date, each
of the  2005  Investors  will  have  the  right,  but  not  the  obligation,  to
participate in such issuance,  upon the same terms as those offered, so that the
2005 Investor's percentage ownership of the Company remains the same.

Forced  Conversion.  Any time after eighteen months following the issue date, we
can  require  the  holders of the Notes to convert  their Notes if (i) the daily
volume weighted average price of Shares for each of 20 consecutive  trading days
is greater than a price per Share derived by multiplying the conversion price by
the number two (2); (ii) we have met various conditions regarding  authorization
to issue shares,  stock exchange listing and  registration of shares;  (iii) the
average daily trading  volume of our Common Stock is at least 450,000 Shares (as
adjusted  for stock  splits and reverse  stock  splits);  and (iv) we are not in
default on the Notes.


                                       21


Change of  Control.  In the event of a change of  control  (which  includes  the
acquisition  by a party of more than  one-third  of the  equity of the  Company)
while the Notes are  outstanding,  the  holders  have the right to require us to
purchase the then outstanding Notes, plus accrued interest,  at 115% of the face
amount of the Notes.

Events of Default.  The Notes  contain  events of default that are customary for
high-yield  securities,  including  failure to make  payments of  principal  and
interest  when due,  breaches  of  covenants,  cross-default  of  capital  lease
obligations and other indebtedness,  change of control,  prepayment of Notes and
other  indebtedness,  bankruptcy,  insolvency,  unsatisfied  judgment  defaults,
delisting  of stock,  failure to  maintain  authorized  shares for  conversions,
failure to  register  shares and  violations  of the  covenants  and  agreements
contemplated in the Purchase Agreement.

Modification,  Amendments. The Purchase Agreement and the Security Agreement may
be amended  with the  consent of the  holders  of a  majority  of the  aggregate
principal  amount of the Notes then  outstanding.  Without  the  consent of each
holder of an outstanding Note, no amendment may, among other things,  (1) reduce
the amount of Notes whose holders must consent to any amendment;  (2) reduce the
rate of or extend the time for payment of  interest on any Note;  (3) reduce the
principal of or extend the maturity of any Note;  or (4) impair the right of any
holder to receive  payment of principal of and interest on such holder's Note on
or after the due dates therefore or to institute suit for the enforcement of any
payment on or with respect to such holder's Note.

Description of the Series A Warrants

The form of the  Series A Warrants  was filed as Exhibit  10.159 to our Form 8-K
filed on April 5,  2005.  The  principal  terms  of the  Series A  Warrants  are
summarized below:

The Series A Warrants  are  exercisable,  at any time after six months  from the
issue  date,  for a period of five years  from the issue  date.  We have  issued
Series A Warrants to purchase an  aggregate of  26,991,667  Shares at $0.325 per
share. The Series A Warrants contain customary  provisions for adjustment of the
exercise  price in the event that we declare a stock  dividend or stock split or
effect any tender offer, merger, consolidation, recapitalization, reorganization
or similar  transaction.  In  addition,  if we issue or sell Common Stock or any
security  convertible or  exchangeable  into Common Stock within one year of the
issue date of the  Series A Warrants  at a price per Share that is less than the
Series A Warrant exercise price on the issue date, the Series A Warrant exercise
price shall be reduced to be equal to such lower price. For example,  if, within
one year from April 4, 2005, we raise  additional  funds by issuing Shares for a
price of $0.21 per Share, the Series A Warrant exercise price would be decreased
from $0.325 per share to $0.21 per share. No additional  Series A Warrant Shares
would be issuable.  Such  adjustment of the Series A Warrant  exercise  price is
subject to exclusions for issuances related to prior transactions, and issuances
to employees  and  consultants,  and  issuances  in  connection  with  strategic
transactions and capital leases.


                                       22


Description of the Agent Fee Warrants

The principal terms of the Agent Fee Warrants are summarized below:

The Agent Fee  Warrants are  exercisable,  at any time after six months from the
issue date, for a period of five years from the issue date. We have issued Agent
Fee  Warrants to  purchase an  aggregate  of 533,333  shares of Common  Stock at
$0.325 per share and an aggregate  of 1,333,333  shares of Common Stock at $0.23
per share.  The Agent Fee Warrants  exercise price is subject to adjustment only
in the event  that we  declare a stock  dividend  or stock  split or effect  any
tender offer, merger, consolidation, recapitalization, reorganization or similar
transaction.

Description of the Series B Warrants

The form of the  Series B Warrants  was filed as Exhibit  10.160 to our Form 8-K
filed on April 5,  2005.  The  principal  terms  of the  Series B  Warrants  are
summarized below:

The Series B Warrants  are  exercisable,  at any time after six months  from the
issue  date,  for a period of five years  from the issue  date.  We have  issued
Series B Warrants to purchase an aggregate of 12,146,250  shares of common Stock
at  $0.325  per  share.  The  Series B  Warrant  exercise  price is  subject  to
adjustment  in the event  that we  declare a stock  dividend  or stock  split or
effect any tender offer, merger, consolidation, recapitalization, reorganization
or similar transaction. At any time after the Series B Warrant can be exercised,
we can require the  holders of the Series B Warrant to exercise  their  Series B
Warrant if (i) the daily volume weighted  average price of Shares for each of 20
consecutive  trading  days  is  greater  than  a  price  per  Share  derived  by
multiplying  the Series B Warrant  Exercise  Price by the number 1.667,  (ii) we
have met various conditions regarding  authorization to issue shares, listing on
an exchange and  registration of shares,  (iii) the average daily trading volume
of our Shares is at least  450,000  shares  (as  adjusted  for stock  splits and
reverse stock splits), and (iv) we are not in default on the Notes.


                                       23


Registration Rights

We have agreed to register  the resale of the  Conversion  Shares,  the Series A
Warrant Shares,  the Series B Warrant Shares and the Agent Fee Warrants.  In the
event we fail to register the Conversion  Shares within the prescribed  time, we
will be  obligated  to pay  liquidated  damages in cash based on our  failure to
timely register those shares.

Limitations  of Conversion of Notes and Exercise of Series A Warrants and Series
B Warrants

The Notes,  the Series A Warrants and the Series B Warrants  contain  provisions
that prevent any holder from  converting any part of the Notes or exercising any
part of the Series A Warrants  or the Series B Warrants  if such  conversion  or
exercise would result in such holder beneficially owning, or having the right to
vote, more than 9.999% of our outstanding shares of Common Stock. This provision
prevents us from  requiring  the  conversion  of any Note or the exercise of any
Series B Warrant  by a holder  that  would  result in such  holder  beneficially
owning, or having the right to vote, more than 9.999% of our outstanding  shares
of Common Stock.  That  limitation  is not contained in the Notes,  the Series A
Warrants and the Series B Warrants  issued to Marr, as Marr  currently owns more
than 9.999% of our outstanding shares of Common Stock.

Voting Agreement

To  facilitate  the approval of Proposal 2, we entered  into a voting  agreement
with Marr and SF Capital  Partners LP ("SF")  pursuant to which each of Marr and
SF agreed to vote its eligible shares of Common Stock in favor of Proposal 2 and
we agreed to use our  reasonable  best efforts to seek approval of Proposal 2 at
our annual stockholders' meeting. Marr and SF will not, however, be permitted to
vote shares of Common  Stock they  acquired as a result of  conversion  of their
Notes or exercise of their Series A Warrants or Series B Warrants on Proposal 2.

Consideration Received

We  issued  $8,000,000  aggregate  principal  amount  of the  Notes  to the 2005
Investors,  for aggregate net proceeds of $7,667,500.  We used $2,000,000 of the
net proceeds to repay the 7% Promissory Note issued to Marr in January 2005. The
balance of the proceeds from the Notes will be used for general  working capital
purposes  as well as for the  commercialization  of our rapid  tests for HIV-1/2
diagnosis.


                                       24


Effect of April 2005 Placement and Stockholder Vote on Existing Stockholders

The exact  number of shares of Common  Stock into which the Notes,  the Series A
Warrants and the Series B Warrants may ultimately be convertible and exercisable
may vary over time as described above. Assuming that all the Notes are converted
into shares of Common Stock on the maturity date at the initial Conversion Price
of $0.30,  the Notes will be converted  into  26,991,667  shares of Common Stock
(excluding  any Shares  issuable as a result of the Notes  Interest  Provision).
Assuming that all the Series A Warrants are exercised on the expiration  date at
the initial  Exercise  Price of $0.325,  the Series A Warrants will be converted
into 26,991,667 shares of Common Stock.  Assuming that all the Series B Warrants
are exercised on the  expiration  date at the initial  Exercise Price of $0.325,
the Series B Warrants will be converted into 12,146,250  shares of Common Stock.
Assuming that all the Agent Fee Warrants are exercised on the expiration date at
their initial exercise prices of $0.30 and $0.23, the Agent Fee Warrants will be
converted  into 1,866,666  shares of Common Stock.  Assuming no other changes in
current   stockholdings  or  shares   outstanding,   the  stockholdings  of  all
stockholders  other than  holders of the  Notes,  the Series A Warrants  and the
Series B Warrants would be diluted from 100% of the total outstanding  shares of
Common  Stock to  approximately  72% of the total  outstanding  shares of Common
Stock.  This dilution could  adversely  affect the market price of the shares of
Common Stock.

If the stockholders approve Proposal 2, the Notes Anti-Dilution  Adjustments and
the Series A  Anti-dilution  Adjustment  will  become  effective.  If we were to
engage in a new equity  issuance  within one year of the issue date of the Notes
at a price per share less than  $0.30,  the  Conversion  Price and the  exercise
price of the  Series A  Warrants  would be  adjusted  downward  pursuant  to the
formulas  described  above. If we were to engage in a new equity issuance within
one year of the issue date of the Notes at a price per share  between  $0.30 and
$0.325,  the  Exercise  Price of the  Series A Warrants  only would be  adjusted
downward  pursuant to the formulas  described above. The downward  adjustment in
the  Conversion  Price (but not in the  exercise  price of the Series A Warrant)
would  result in the  issuance  of a greater  number of  Conversion  Shares upon
conversion  of  the  Notes  thereby   resulting  in  greater   dilution  of  all
stockholders  other than  holders of the  Notes,  the Series A Warrants  and the
Series B Warrants.

If  the  stockholders  do  not  approve  Proposal  2,  the  Notes  Anti-Dilution
Adjustments and the Series A Warrants  Anti-dilution  Adjustment will not become
fully  effective,  although  all other  provisions  of the  Notes,  the Series A
Warrants and the Series B Warrants will remain outstanding and will be otherwise
unaffected. Specifically, if the stockholders do not approve Proposal 2, (i) the
Notes  Anti-Dilution  Adjustments  will not be  effective to the extent it would
result in the  decrease  of the  Conversion  Price and  issuance  of  additional
Conversion  Shares in connection  with  subsequent  events  triggering the Notes
Anti-Dilution Adjustment Provision; and (ii) the Series A Warrants Anti-dilution
Adjustment  will not be  effective to the extent it would result in the decrease
of the exercise price of the Series A Warrants.

Approval Required

Approval  of  Proposal  2 requires  the  affirmative  vote of a majority  of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.

The Board  recommends a vote FOR Proposal 2 to approve the issuance of Shares in
excess of 19.99% of our  outstanding  Common Stock in connection with the rights
granted in the Notes,  the  Series A Warrants  and the Series B Warrants  and to
authorize the conversion price and exercise  adjustments in the Notes and Series
A Warrants.  All  proxies  solicited  by the Board will be voted FOR  Proposal 2
unless stockholders specify a contrary choice in their proxies.


                                       25


   PROPOSAL TO APPROVE THE ISSUANCE OF ADDITIONAL SHARES OF COMMON STOCK AND
   WARRANT SHARES AND ADJUSTMENT OF WARRANT EXERCISE PRICE IN CONNECTION WITH
AMENDED SECURITIES GRANTED TO THE INVESTORS IN OUR MAY AND JULY 2004 PLACEMENTS
                                  (Proposal 3)

On May 28, 2004, and July 9, 2004, we concluded two separate,  unrelated private
placements  (together,  the 2004  Transactions")  of  Shares  and  common  stock
purchase warrants (the "2004 Warrants") to 12 institutional investors (the "2004
Investors").  In the 2004 Transactions we issued,  in the aggregate,  26,970,000
Shares and 2004  Warrants to purchase  10,741,500  Shares  (the  "Original  2004
Warrant Shares").  The 2004 Investors were granted one-year anti-dilution rights
(the "2004  Anti-dilution  Rights")  that would be  triggered by our issuance of
Shares or securities  convertible  or  exchangeable  into Shares at a price less
than $0.40 per Share. Subsequent to the 2004 Transactions,  as a prerequisite to
the  listing of our Shares on AMEX,  we agreed  with AMEX  that,  without  first
obtaining prior stockholder  approval,  we would not issue any additional Shares
to the 2004  Investors,  increase  the number of Original  2004  Warrant  Shares
issuable as a result of a decrease of the exercise  price of the 2004  Warrants,
pursuant to the 2004 Anti-dilution Rights.

The terms of the April 2005  Placement,  described  in  Proposal 2 of this Proxy
Statement,  would have triggered the 2004 Anti-dilution  Rights, which, if given
effect before being approved by our Stockholders,  would have caused us to be in
breach of our  listing  agreement  with AMEX.  Due to the urgency of our need to
obtain additional  working capital in early 2005, we entered into the April 2005
Placement before seeking stockholder approval of the 2004 Anti-dilution  Rights.
In order to do so and to comply with the AMEX requirements  applicable to us, we
entered into an amendment  agreement with the 2004 Investors (the  "Amendment"),
in which we agreed to revise  the 2004  Anti-dilution  Rights and grant the 2004
Investors  additional  rights (as described below) and the 2004 Investors agreed
to  subject  the  applicability  of  the  2004  Anti-dilution   Rights  and  the
effectiveness  of  the  Amendment  to  approval  by  our  stockholders,  thereby
permitting  us to complete  the April 2005  Placement  prior to  obtaining  such
stockholder approval without violating AMEX's requirements.  Proposal 3 requests
our  stockholders  to approve our issuance to the 2004  Investors of  additional
Shares and additional  2004 Warrants and the adjustment of the exercise price of
the currently outstanding 2004 Warrants, as provided in the Amendment. Our Board
of Directors recommends that stockholders vote for Proposal 3.

The Amendment,  if approved by our stockholders,  amends the respective terms of
the 2004  Transactions  to provide for the following  cumulative  changes in the
securities   issued  to  the  2004   Investors   (collectively,   the   "Amended
Securities"). (Amounts in parenthesis are the original 2004 Anti-dilution Rights
due as a result of the April 2005 Placement.)

      (1)   an increase to 7,079,625 (from 6,742,500) in the number of Shares to
            be issued, as a result of the April 2005 Placement,  pursuant to the
            2004 Anti-dilution Rights;

      (2)   an increase, as a result of the April 2005 Placement,  in the number
            of 2004 Warrants to purchase  1,253,177 (from 1,193,501)  Shares, at
            an exercise price of $0.325 (reduced from $0.45) per Share; and

      (3)   an adjustment, as a result of the April 2005 Placement, of the $0.50
            per  share  exercise price of  the Original  2004 Warrant  Shares to
            $0.45 per Share.


                                       26



Registration Rights with Respect to the Amended Securities

The  additional  Shares  issuable  pursuant to the Amendment  will  initially be
restricted  securities and together with additional  Shares issued upon exercise
of the 2004 Warrants will be subject to the  registration  rights granted in the
2004  Transactions,  which are customary  registration  rights for the resale of
common stock  issued in private  placements.  The initial 2004  Warrants are all
still held by the 2004  Investors  and the  additional  Shares and warrants will
only be issued to the 2004 Investors.

Voting Agreement with Respect to the Amendment

To  facilitate  the approval of Proposal 3, we entered  into a voting  agreement
with Marr, our largest current  stockholder and our largest stockholder prior to
the 2004  Transactions,  pursuant to which Marr has agreed to vote its  eligible
Shares in favor of Proposal 3 and we agreed to use our  reasonable  best efforts
to seek approval of Proposal 3 at our annual  stockholders'  meeting.  Marr will
not,  however,  be permitted to vote Shares it acquired in the 2004 Transactions
on Proposal 3.

No Additional Consideration Received from the Amended Securities

We will not receive any additional consideration in connection with the issuance
of  the  Amended  Securities,  unless  some  or all of  the  2004  Warrants  are
exercised.

Effect of the Amendment on Existing Stockholders

If the  stockholders  approve  Proposal 3, the rights of the Amended  Securities
will become  effective and we will (i) issue 7,079,625  Shares,  (ii) reduce the
exercise price of the 10,741,500 2004 Warrants issued in the 2004 Placements and
currently  held by the 2004  Investors  from $0.50 per share to $0.45 per Share;
and (iii) issue  1,253,177  Additional  2004 Warrant Shares at $0.325 per Share.
Assuming no other changes in current  stockholdings or shares  outstanding,  the
issuance  of  the  Amended  Securities  will  dilute  the  stockholdings  of all
stockholders other than stockholders  receiving the Amended Securities from 100%
of the total  outstanding  shares of Common  Stock to  approximately  95% of the
total  outstanding  shares of Common Stock. This dilution could adversely affect
the market price of the shares of Common Stock.

If the  stockholders  do not  approve  Proposal  3, the  rights  of the  Amended
Securities will not become effective,  although all other provisions of the 2004
Placements and 2004 Warrants will remain fully effective. The 2004 Anti-dilution
Rights will remain fully effective with respect to any future  financings to the
extent  that they occur  within one year of the 2004  Placements  and at a price
below $0.40 per share.

If the  stockholders  do not  approve  Proposal  3 at the  annual  stockholders'
meeting, we are contractually obligated by the terms of the Amendment to use our
reasonable best efforts to continue to seek approval of Proposal 3. Accordingly,
while we will owe no penalties to the 2004 PIPE  Investors for failure to obtain
stockholder approval of Proposal 3, we will be required to bear certain marginal
costs to include such proposal in our proxy  materials for every meeting we hold
on a going-forward basis until such proposal is approved by our stockholders.

Approval Required

Approval  of  Proposal  3 requires  the  affirmative  vote of a majority  of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.

The Board  recommends  a vote FOR  Proposal 3 to approve the  Amendment  and the
Amended  Securities.  All  proxies  solicited  by the  Board  will be voted  FOR
Proposal 3 unless stockholders specify a contrary choice in their proxies.


                                       27


            PROPOSAL TO ADOPT THE CALYPTE BIOMEDICAL CORPORATION 2005
                            DIRECTOR INCENTIVE PLAN
                                  (Proposal 4)

      On  March  7,  2005,  the  Board  adopted,  subject  to  approval  by  the
stockholders  at the Annual Meeting,  the Calypte  Biomedical  Corporation  2005
Director  Incentive  Plan,  (the  "2005  Director  Plan").  The text of the 2005
Director Plan is attached as Appendix A to this Proxy Statement Stockholders are
being asked to approve the adoption of the 2005 Director Plan and to approve the
reservation for issuance thereunder of up to 18,000,000 shares of Common Stock.

      Purpose.  The purpose of the 2005  Director  Plan is to attract and retain
the best available personnel for service as Outside Directors of the Company and
its affiliates,  to provide additional incentive to the Outside Directors of the
Company  and its  affiliates  to  serve as  directors,  and to  encourage  their
continued  service.  Outside  Director,  for purposes of the 2005  Director Plan
only, means a Director who is not an employee or a greater than 10% stockholder,
directly or beneficially, of the Company or an Affiliate. The 2005 Director Plan
is designed to permit the Company to provide  several  different forms of awards
to meet varying  conditions,  including  incentive stock options,  non-qualified
stock options, stock appreciation rights, dividend equivalent rights, restricted
stock,  restricted stock units, other  equity-based or equity-related  award and
incentive awards based on achievement of performance  goals  (collectively,  the
"Awards").

      General.  The 2005  Director Plan  authorizes  the granting of Awards with
respect to an aggregate of  18,000,000  shares of Common Stock.  The  18,000,000
shares  reserved  under the 2005  Director Plan equal  approximately  11% of the
outstanding Common Stock as of May 13, 2005. The 2005 Director Plan will replace
the 1995 Director  Option Plan (the "1995 Plan"),  which expires under its terms
later this year.  As of May 13, 2005,  under the 1995 Plan,  options to purchase
1,329,413  shares of Common Stock were  outstanding  and 662,229 shares reserved
were  available  for  additional  grants.  The Common Stock  covered by the 2005
Director Plan may be either  authorized but unissued shares or treasury  shares.
If there is a forfeiture,  expiration,  termination,  cancellation or settlement
for cash of any Award  granted under the 2005 Director Plan without the issuance
of shares, the shares covered by such forfeited, terminated or canceled Award or
equal to the number of shares settled, surrendered,  withheld or tendered, shall
again become  available for transfer  pursuant to Awards under the 2005 Director
Plan.

      The following  summary of certain  provisions of the 2005 Director Plan is
qualified in its entirety by reference to the copy of the 2005 Director Plan set
forth in Appendix A to this Proxy Statement.

      Administration.  The 2005 Director Plan provides that grants of Awards and
other  determinations  under  the  Plan  shall  be made by (i) the  Compensation
Committee  of the Board or (ii) the Board (the  "Administrator").  To the extent
required  for Awards to qualify for the  exemptions  available  under Rule 16b-3
promulgated under the Exchange Act, the Compensation  Committee will be composed
of two or more  directors,  each of whom is a  "non-employee  direct" within the
meaning of Exchange  Act Rule 16b-3.  To the extent  required  for  compensation
realized from Awards to be deductible by the Company  pursuant to Section 162(m)
of the Internal Revenue Code of 1986, as amended (the "Code"),  the Compensation
Committee will be composed of two or more directors, each of whom is an "outside
director" within the meaning of Section 162(m) of the Code.

      The 2005 Director Plan does not limit the number of shares with respect to
which  incentive  stock  options,   non-qualified   stock  options,   and  stock
appreciation  rights may be granted in any one calendar  year to any  individual
Outside Director.

      Eligibility.  Awards  under  the 2005  Director  Plan may be made  only to
Outside Directors in recognition of such Director's  service on the Board and/or
on one or more Committees of the Board.

      Types of Awards.  Awards may be made under the 2005  Director  Plan in the
form of (a) options,  (b) stock  appreciation  rights,  (c) dividend  equivalent
rights,  (d)  restricted  stock,  (e)  restricted  stock  units,  and (f)  other
equity-based  or  equity-related  Awards which the  Committee  determines  to be
consistent  with the purpose of the 2005  Director Plan and the interests of the
Company (including, but not limited to, stock bonuses and warrants).

                                       28



                  Stock Options.  The 2005 Director Plan permits the granting of
            stock  options  whose  terms  will  be  solely   determined  by  the
            Compensation Committee.  The exercise price of options granted under
            the 2005  Director  Plan may be paid in cash or by such other method
            as  the  Committee  may  prescribe,   provided,  however,  that  any
            participant  exercising  rights and  obtaining  shares  pursuant  to
            awards  granted  under the 2005 Director Plan must pay cash or other
            valid  consideration equal to the aggregate par value of such shares
            to the extent required by the Delaware General Corporation Laws. Any
            taxes required to be withheld must be paid by the participant at the
            time of  exercise.  The  Company  may  deduct or  withhold  from any
            payment  or  distribution  an  amount  sufficient  to  satisfy  such
            withholding  obligation.  The  grantee may elect to have the Company
            withhold  shares  of Common  Stock or may  tender  previously  owned
            shares of Common Stock to satisfy the  withholding  obligation.  The
            period  of  any  option  will  be  determined  by  the  Compensation
            Committee,  but no option may be exercised  after the  expiration of
            ten years from the date it is granted.  Option  awards will  provide
            rules  covering  the  time  of  exercise  of an  option  in  case of
            retirement,  death, disability, or other termination of service as a
            Director.

                  Stock Appreciation  Rights. The 2005 Director Plan permits the
            granting of stock  appreciation  rights in  conjunction  with all or
            part of a stock option  granted under the 2005 Director  Plan.  Such
            rights may be  granted  either at or after the date of grant of such
            Option.  Stock appreciation  rights will be exercisable only at such
            time and to the extent  that the stock  options to which they relate
            are  exercisable.  Upon exercise of a stock  appreciation  right,  a
            Participant  will  receive an amount equal to the product of (a) the
            excess of the fair  market  value of one share of Common  Stock over
            the exercise  price per share  specified in the related stock option
            times  (b) the  number  of  shares  in  respect  of which  the stock
            appreciation  right shall have been  exercised,  in cash,  shares of
            Common Stock or both,  with the  Compensation  Committee  having the
            right to determine the form of payment.

                  Dividend Equivalent Rights. The 2005 Director Plan permits the
            Compensation Committee to include in any award a dividend equivalent
            right  entitling the  participant to receive amounts equal to all or
            any  portion  of the  dividends  that would be paid on the shares of
            Common Stock covered by the Award if such shares had been  delivered
            pursuant to the Award.  The  Compensation  Committee  will determine
            whether the payment of  dividend  equivalent  rights will be made in
            cash,  in shares of Common  Stock or in another  form,  whether they
            shall be  conditioned  upon the  exercise of the Award to which they
            relate,  the time at which they shall be made,  and such other terms
            and conditions as the Committee considers appropriate.

                  Restricted  Stock Awards and Restricted  Stock Units. The 2005
            Director   Plan  permits  the  granting  of  or  offering  for  sale
            restricted shares of Common Stock and restricted stock units in such
            amounts and subject to such terms and conditions as the Compensation
            Committee may determine. Upon receipt of restricted shares of Common
            Stock,  the participant has the rights of a shareholder with respect
            to the restricted stock,  subject to any restrictions and conditions
            that the Compensation  Committee may impose. On the delivery date of
            a  restricted  stock unit,  the  participant  receives  one share of
            Common  Stock or cash equal in value to a share of Common Stock or a
            combination thereof, as specified by the Compensation Committee.

                  Other Stock-Based  Awards.  The 2005 Director Plan permits the
            Compensation  Committee  to grant  other  types of  equity-based  or
            equity-related  awards  (including  the  grant or offer  for sale of
            unrestricted  shares of Common Stock) in such amounts and subject to
            such  terms  and  conditions  as  the  Compensation   Committee  may
            determine.  Such awards may entail the transfer of actual  shares of
            Common  Stock to  participants  or payment in cash or  otherwise  of
            amounts based on the value of shares of Common Stock.

                  Tax Offset Bonuses. The Compensation  Committee may grant to a
            participant a specified  amount of cash for the purpose of assisting
            the participant to pay taxes resulting from the grant of an Award.

      Change in Control.  The Committee  may provide in any award  agreement for
provisions relating to a "change in control" of the Company, including,  without
limitation, the acceleration or extension of the exercisability of, or the lapse
of restrictions or deemed satisfaction of goals with respect to, any outstanding
Awards.  Unless otherwise  provided in a participant's  award agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of the  Company  with  or  into  any  other  entity  (the
"successor  entity")  or any  transaction  in which  another  person  or  entity
acquires all of the Company's  issued and  outstanding  Common Stock, or all, or
substantially all, of the Company's assets, outstanding Awards may be assumed or
an equivalent  Award may be substituted  by the successor  entity or a parent or
subsidiary of the successor entity.


                                       29




      Amendment  of the 2005  Director  Plan.  The  Board  may from time to time
alter, suspend,  discontinue,  revise, amend or terminate the 2005 Director Plan
in any  respect  whatsoever,  provided,  that no such  modification  of the 2005
Director Plan shall  adversely  affect in any material way any award  previously
granted  under the 2005  Director  Plan,  without  the  written  consent  of the
participant who received such award.  However,  the Board may not amend, without
stockholder  approval,  the  2005  Director  Plan in any  manner  that  requires
stockholder  approval  pursuant  to  the  Code  or the  regulations  promulgated
thereunder,  or pursuant to the  Exchange  Act or Rule 16b-3 (or its  successor)
promulgated thereunder.

      Term of the 2005 Director Plan. Unless  terminated  earlier as provided in
the 2005  Director  Plan,  the 2005 Director Plan will expire ten years from its
effective date, which shall be the date on which it is approved by the Company's
stockholders.

Certain Federal Income Tax Consequences

      The following  summary of federal  income tax  consequences  is based upon
existing statutes, regulations and interpretations thereof. The applicable rules
are complex,  and income tax consequences may vary depending upon the particular
circumstances of each plan participant.  This Proxy Statement  describes federal
income  tax  consequences  of  general  applicability,  but does not  purport to
describe either  particular  consequences to each individual plan participant or
foreign,  state or local  income tax  consequences,  which may  differ  from the
United States federal income tax consequences.

Stock Options and Stock Appreciation Rights

      Award;  Exercise. The grant of stock options and stock appreciation rights
under  the  2005  Director  Plan  will  not  result  in  income  taxable  to the
participant  or provide a deduction to the Company.  However,  the exercise of a
stock  option or a stock  appreciation  right  results in taxable  income to the
holder, and the Company is entitled to a corresponding deduction. At the time of
the exercise of a stock option,  the amount so taxable and so deductible will be
the excess of the fair market  value of the shares  purchased  over their option
price. Upon the exercise of a stock appreciation  right, the participant will be
taxed at ordinary income tax rates on the amount of the cash and the fair market
value of the shares  received by the employee,  and the Company will be entitled
to a corresponding deduction.

      Sale of Option  Shares.  Upon sale,  other than to the Company,  of shares
acquired under a stock option, an optionee generally will recognize capital gain
or  loss  to the  extent  of the  difference  between  the  sale  price  and the
optionee's tax basis in the shares,  which will be long-term gain or loss if the
employee's  holding  period in the shares is more than one year.  Certain  lower
rates apply if the shares have been held for longer periods. If stock is sold to
the Company rather than to a third party,  the sale may not produce capital gain
or loss.  A sale of shares to the Company will  constitute a redemption  of such
shares,  which  could be  taxable as a dividend  unless the  redemption  is "not
necessarily equivalent to a dividend" within the meaning of the Code.

      Exercise  with Stock.  If an optionee  tenders  Common Stock to pay all or
part of the  exercise  price of a stock  option,  the  optionee  will not have a
taxable gain or  deductible  loss on the  surrendered  shares.  Instead,  shares
acquired  upon  exercise that are equal in value to the fair market value of the
shares  surrendered in payment are treated as if they had been  substituted  for
the surrendered  shares,  taking as their basis and holding period the basis and
holding period that the optionee had in the surrendered  shares.  The additional
shares are treated as newly  acquired,  are taxable to the optionee,  and have a
basis equal to their fair market value on the exercise date.

      If the  surrendered  shares are statutory  option  stock,  with respect to
which the  applicable  holding  period  requirements  for  favorable  income tax
treatment have not expired,  then the newly acquired shares  substituted for the
statutory  option shares should remain  subject to the federal  income tax rules
governing the  surrendered  shares,  but the surrender  should not  constitute a
Disqualifying Disposition of the surrendered stock.

Restricted Stock Awards and Restricted Stock Units

      Award;  Exercise.  A  participant  who is  granted a  restricted  award or
restricted  stock unit will not  recognized  taxable  income upon the receipt of
such shares or stock units so long as the interest in such shares or stock units
is subject to a "substantial  risk of forfeiture"  within the meaning of Section
83 of the Code.  Upon lapse or release of the  restrictions,  the recipient will
recognize  taxable income at ordinary income tax rates on an amount equal to the
fair market value of the shares or stock units less the amount of any price paid
for the shares or stock units.  The Company will be entitled to a  corresponding
deduction  when the value of the award is  included in the  recipient's  taxable
income.  The basis of  restricted  shares or  restricted  stock units held after
lapse or termination of restrictions will be equal to their fair market value on
the  date  of  lapse  or  termination  of  restrictions,   and  upon  subsequent
disposition  any further gain or loss will be long-term  or  short-term  capital
gain or loss,  depending  upon the length of time the shares or stock unites are
held. A  participant  may elect to be taxed at ordinary  income tax rates on the
full fair market value of the restricted shares or restricted stock units at the
time of transfer.  If the election is not made, the basis of the shares or stock
units  so  acquired  will be  equal  to the  fair  market  value  at the time of
transfer.  If the election is made,  no tax will be payable upon the  subsequent
lapse or release of the restrictions, and any gain or loss upon disposition will
be a capital gain or loss.


                                       30


Other Stock Based Awards and Incentive Awards

      Award; Exercise. A participant will realize ordinary income as a result of
performance awards at the time Common Stock is transferred or cash is paid in an
amount equal to the value of the shares delivered plus the cash paid.

Option Grants Contingent upon Stockholder Approval of the 2005 Director Plan

      The  Compensation  Committee has not made or proposed any option grants or
other awards under the 2005 Director Plan that will become effective  subject to
stockholder approval of this Proposal 4.

Approval Required

      Approval of Proposal 4 requires the affirmative  vote of a majority of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.

      The  Board  unanimously  recommends  a vote FOR the  approval  of the 2005
Director  Plan.  Proxies  solicited  by  the  Board  will  be  so  voted  unless
stockholders specify a different choice in their proxies.


                                       31



     PROPOSAL TO ADOPT AMENDMENTS TO THE CALYPTE BIOMEDICAL CORPORATION 2004
                                 INCENTIVE PLAN
                                  (Proposal 5)

         On February 24,  2004,  the Board  adopted,  subject to approval by the
stockholders at the 2004 Annual Meeting of Stockholders,  the Calypte Biomedical
Corporation 2004 Incentive Plan, (the "2004 Plan").  Our  stockholders  approved
the adoption of the 2004 Plan and the reservation of 30,000,000 shares of Common
Stock for issuance  thereunder  at the Annual  Meeting held on June 22, 2004. On
March 7, 2005, the Board unanimously approved,  subject to stockholder approval,
an  amendment  to the 2004 Plan  increasing  the number of shares  reserved  for
issuance thereunder and certain other modifications.

         In this  Proposal  5,  stockholders  are  being  asked  to  approve  an
amendment  to the 2004 Plan to (i) increase by  17,000,000  shares the number of
shares of Common  Stock  reserved  for  issuance  thereunder,  (ii)  permit  the
granting  of awards  under  the 2004  Plan to  employees  and  others  providing
services to the Company's  affiliates,  and (iii) increase from 8,000,000 shares
to 20,000,000  shares the maximum  number of shares which shall be available for
delivery as restricted  stock and restricted  stock units.  The text of the 2004
Plan, as amended subject to stockholder approval of this Proposal 5, is attached
as Appendix B to this Proxy Statement

Background of the Proposal

         Subject to the approval of the amendment by the Company's stockholders,
the 2004 Plan will authorize the granting of Awards with respect to an aggregate
of 47,000,000 shares of Common Stock. In April 2004, when the Company issued the
Proxy that  requested  its  stockholders  approve the adoption of the 2004 Plan,
they also  requested  that  30,000,000  shares of the Company's  Common Stock be
reserved  for  issuance  under  the  2004  Plan,  an  amount  which  represented
approximately 21% of the Company's  then-outstanding  Common Stock. As of May 2,
2005,  the Company has issued  options to purchase  approximately  21.6  million
shares of its  Common  Stock  under the 2004  Plan,  leaving  approximately  8.4
million shares reserved and available for additional grants. Based on the number
of shares of Common  Stock  outstanding  at May 2, 2005 and the number of shares
potentially issuable upon the conversion of the Secured 8% Convertible Notes due
on April 3, 2007 and the related  Series B Warrants  which the Company issued on
April 4,  2005,  the  latter of which the  Company  may be able,  under  certain
conditions,  to  require  the  investors  to  exercise,  both of which have been
described more completely in Proposal 3 herein,  the increased  number of shares
proposed for reservation under the 2004 Plan would again represent approximately
21% of the  Company's  outstanding  and  potentially  issuable  shares of Common
Stock. The Company believes that the requested  17,000,000 share increase in the
number of shares reserved for issuance is required for the flexibility necessary
to provide appropriate incentives to employees, potential employees, consultants
and  other  parties  to whom  awards  may be made  under the 2004 Plan that will
encourage  loyalty to Calypte and continue to align  interests of grantees  with
those of Calypte's stockholders. Subject to the approval of this Proposal by the
stockholders,  there will be  approximately  25.2 million shares of Common Stock
reserved and available for grants under the 2004 Plan,  which number the Company
estimates  should  be  adequate  to  satisfy  its  award  requirements  for  the
foreseeable  future.  The  Common  Stock  covered by the 2004 Plan may be either
authorized  but unissued  shares or treasury  shares.  If there is a forfeiture,
expiration,  termination,  cancellation  or  settlement  for  cash of any  Award
granted under the 2004 Plan without the issuance of shares,  the shares  covered
by such forfeited, terminated or canceled Award or equal to the number of shares
settled,  surrendered,  withheld or tendered,  shall again become  available for
transfer pursuant to Awards under the 2004 Plan.

         As Calypte's business expands internationally,  we have entered into an
affiliate  arrangement to manufacture  and market our products in China.  In the
future,  we may create or acquire other affiliated  entities in other locations.
To provide  incentives  and awards for  managers,  employees  and others who may
provide services to these affiliated  entities and to align their interests more
closely  with those of Calypte and our  stockholders,  the Board and the Company
believe it  appropriate to permit the granting of options and other awards under
the 2004 Plan to  employees,  consultants  and others who  provide  services  to
Calypte's  affiliates.  Since the 2004 Plan, as originally adopted,  limited the
granting of awards  under the Plan to parties  performing  services as Calypte's
employees or  consultants,  stockholders  are now being  requested to expand the
eligibility  of awards to include  parties  who provide  services  to  Calypte's
affiliated entities.



                                       32


         Although Calypte has historically  awarded stock options as its primary
equity incentive,  the 2004 Plan permits other  equity-based  awards,  including
restricted stock and restricted  stock units. As adopted,  the 2004 Plan limited
to  8,000,000  shares the  aggregate  number of shares  that could be awarded as
restricted  stock or restricted  stock units.  The Board and the Company believe
that it is  necessary  for  Calypte to continue  to provide  competitive  equity
incentives to attract and retain the services of qualified employees, executives
and consultants and to better align their interests with those of  stockholders.
Additionally,  the Board and the  Company  are  reviewing  Financial  Accounting
Standards  Board  Statement No. 123,  Share Based  Payments,  (Revised 2004) and
believe that a greater  degree of flexibility  than was originally  contemplated
may be necessary  with respect to the types of awards that may be granted  under
the 2004 Plan.  Accordingly,  the Board is recommending that the aggregate limit
on the number of shares of restricted  stock and restricted stock units that can
be issued under the 2004 Plan be increased from  8,000,000  shares to 20,000,000
shares. This proposed amendment will provide Calypte the flexibility to continue
to offer competitive equity incentives as desired.

Description of the 2004 Plan

         The following summary of certain provisions of the 2004 is qualified in
its  entirety  by  reference  to the copy of the 2004  Plan,  incorporating  the
proposed amendments, which is set forth in Appendix B to this Proxy Statement.

         Purpose.  The  purpose  of the  2004  Plan is to  attract,  retain  and
motivate officers, employees (including prospective employees),  consultants and
others who may perform  services for the Company or an affiliate,  to compensate
them for their  contributions to the long-term growth and profits of the Company
or an affiliate,  and to encourage them to acquire a proprietary interest in the
success of the Company by providing them with the  opportunity to acquire Common
Stock or to receive monetary  payments based on the value of the Common Stock or
on the financial performance of the Company, or both, on advantageous terms. The
2004 Plan is designed to permit the Company to provide  several  different forms
of awards to meet  competitive  conditions,  including  incentive stock options,
non-qualified  stock options,  stock appreciation  rights,  dividend  equivalent
rights,   restricted  stock,  restricted  stock  units,  other  equity-based  or
equity-related  award and incentive  awards based on  achievement of performance
goals (collectively, the "Awards").

         Administration.  The 2004 Plan provides that grants of Awards and other
determinations under the Plan shall be made by (i) the Compensation Committee of
the Board or (ii) the Board (the  "Administrator").  To the extent  required for
Awards to qualify  for the  exemptions  available  under Rule 16b-3  promulgated
under the Exchange Act, the  Compensation  Committee  will be composed of two or
more directors,  each of whom is a  "non-employee  direct" within the meaning of
Exchange Act Rule 16b-3. To the extent required for  compensation  realized from
Awards  to be  deductible  by the  Company  pursuant  to  Section  162(m) of the
Internal  Revenue  Code of 1986,  as  amended  (the  "Code"),  the  Compensation
Committee will be composed of two or more directors, each of whom is an "outside
director" within the meaning of Section 162(m) of the Code.

         Performance Based Compensation. Section 162(m) of the Code limits to $1
million  annually the income tax  deduction a public  corporation  may claim for
compensation paid to any of its top five executive  officers,  except in limited
circumstances. One such exception is for "performance based compensation," which
is defined as  compensation  paid solely on account of the  attainment of one or
more  performance  goals,  but  only  (1)  if  the  goals  are  determined  by a
compensation  committee  of the  board  of  directors  comprised  of two or more
outside  directors,  (2) the performance goals are disclosed to stockholders and
approved by a majority vote before the  remuneration is paid, and (3) before the
remuneration is paid, the Compensation  Committee certifies that the performance
goals and any other material terms were in fact satisfied.

         Internal  Revenue  Service   regulations   provide  that   compensation
attributable  to a stock  option or stock  appreciation  right will be deemed to
satisfy the requirement that performance goals be preestablished if the grant of
the award is made by a properly appointed  Compensation  Committee  appointed by
the Board;  the plan under which the award is granted  states the maximum number
of shares  with  respect to which  options  or rights  may be  granted  during a
specified  period to any employee;  and, under the terms of the option or award,
the amount of  compensation  the  employee  could  receive is based solely on an
increase in the value of the stock after the date of the grant or award.  In the
case of all other types of awards, the performance  criteria must be established
within 90 days  after the  commencement  of the  period of  service to which the
performance goal relates, and the performance goal must be objective and capable
of determination by a third party having knowledge of the relevant facts.



                                       33


         The 2004 Plan includes features intended to permit the Administrator to
grant Awards to employees that will qualify as  performance-based  compensation.
The 2004 Plan limits the number of shares with respect to which  incentive stock
options,  non-qualified  stock  options,  and stock  appreciation  rights may be
granted in any one calendar year to any one individual  participant to 8,000,000
shares of Common Stock.  The 2004 Plan further  limits the number of shares with
respect to which restricted stock or restricted stock units may be granted to an
aggregate of 20,000,000 shares of Common Stock. The 2004 Plan also provides that
the  total  value  of  any  Award  intended  to  qualify  as   performance-based
compensation  granted to any one individual  participant in any calendar year is
limited to $1 million,  based upon the value of the Award  assuming  performance
goals  met on the date of the  Award  grant.  The 2004  Plan  provides  that the
Administrator  may condition  exercise of an Award on attainment of an objective
performance  goal or  goals  based on one or more of the  following  performance
criteria:  earnings  (either in the  aggregate or on a per-share  basis),  total
stockholder return,  return on equity, return on capital, net income, cash flow,
operating income or profit,  gross revenues,  economic value added, or strategic
business  criteria.   The  levels  of  performance   required  with  respect  to
Performance Goals may be expressed in absolute or relative levels.

         Eligibility.  Awards under the 2004 Plan may be made to such  officers,
employees (including prospective  employees),  consultants and other individuals
who may perform  services for the Company or an Affiliate,  as the  Compensation
Committee may select.

         Types of Awards.  Awards may be made under the 2004 Plan in the form of
(a) options,  (b) stock appreciation rights, (c) dividend equivalent rights, (d)
restricted  stock,  (e)  restricted  stock  units,  (f)  other  equity-based  or
equity-related  Awards which the Committee  determines to be consistent with the
purpose of the 2004 Plan and the  interests of the Company  (including,  but not
limited to, stock bonuses and warrants),  and (g) incentive awards. No incentive
stock option may be granted to a non-employee.

                  Stock  Options.  The  Incentive  Plan  permits the granting of
         options  that  are  either   incentive   stock   options   ("ISOs")  or
         nonqualified  stock  options  ("NSOs").  ISOs  may be  granted  only to
         employees  (including officers and directors who are also employees) of
         the Company or any parent, subsidiary, or affiliate of the Company. The
         option  exercise  price for each ISO share must be no less than 100% of
         the "fair  market  value"  (as  defined in the 2004 Plan) of a share of
         Common  Stock  at the time  the ISO is  granted.  In the case of an ISO
         granted  to a 10%  stockholder,  the  exercise  price for each such ISO
         share must be no less than 110% of the fair market  value of a share of
         Common  Stock at the time the ISO is  granted.  If the shares of Common
         Stock subject to a participant's  ISO which become  exercisable for the
         first time during any calendar  year have a fair market value in excess
         of $100,000, the options for the excess will be treated as NSOs.

                  The exercise price of options  granted under the 2004 Plan may
         be paid in cash or by such other method as the Committee may prescribe,
         provided, however, that any participant exercising rights and obtaining
         shares  pursuant to awards granted under the 2004 Plan must pay cash or
         other  valid  consideration  equal to the  aggregate  par value of such
         shares to the extent required by the Delaware General Corporation Laws.
         Any taxes  required to be withheld must be paid by the  participant  at
         the time of  exercise.  The  Company  may deduct or  withhold  from any
         payment  or   distribution   an  amount   sufficient  to  satisfy  such
         withholding  obligation.  The  grantee  may  elect to have the  Company
         withhold shares of Common Stock or may tender  previously  owned shares
         of Common Stock to satisfy the  withholding  obligation.  The period of
         any option will be determined by the  Administrator,  but no option may
         be  exercised  after the  expiration  of ten years  from the date it is
         granted. Option awards will provide rules covering the time of exercise
         of an  option  in case  of  retirement,  death,  disability,  or  other
         termination of employment

                  Stock Appreciation  Rights. The 2004 Plan permits the granting
         of stock appreciation rights in conjunction with all or part of a stock
         option  granted  under the 2004 Plan. In the case of a NSO, such rights
         may be granted either at or after the date of grant of such Option.  In
         the case of an ISO,  such  rights  may be  granted  only at the date of
         grant of such Option.  Stock  appreciation  rights will be  exercisable
         only at such time and to the  extent  that the stock  options  to which
         they relate are  exercisable.  Upon  exercise  of a stock  appreciation
         right, a Participant will receive an amount equal to the product of (a)
         the excess of the fair market  value of one share of Common  Stock over
         the  exercise  price per share  specified  in the related  stock option
         times  (b)  the  number  of  shares  in  respect  of  which  the  stock
         appreciation right shall have been exercised, in cash, shares of Common
         Stock or both,  with the  Compensation  Committee  having  the right to
         determine the form of payment.



                                       34


                  Dividend   Equivalent   Rights.  The  2004  Plan  permits  the
         Compensation  Committee  to include in any award a dividend  equivalent
         right  entitling the participant to receive amounts equal to all or any
         portion  of the  dividends  that  would be paid on the shares of Common
         Stock covered by the Award if such shares had been  delivered  pursuant
         to the Award.  The  Compensation  Committee will determine  whether the
         payment of dividend  equivalent  rights will be made in cash, in shares
         of Common Stock or in another form,  whether they shall be  conditioned
         upon the exercise of the Award to which they relate,  the time at which
         they  shall be  made,  and  such  other  terms  and  conditions  as the
         Committee considers appropriate.

                  Restricted  Stock Awards and Restricted  Stock Units. The 2004
         Plan permits the granting of or offering for sale restricted  shares of
         Common Stock and restricted  stock units in such amounts and subject to
         such terms and conditions as the Compensation  Committee may determine.
         Upon receipt of restricted  shares of Common Stock, the participant has
         the  rights of a  shareholder  with  respect to the  restricted  stock,
         subject  to any  restrictions  and  conditions  that  the  Compensation
         Committee may impose.  On the delivery date of a restricted stock unit,
         the  participant  receives  one share of Common  Stock or cash equal in
         value to a share of Common Stock or a combination thereof, as specified
         by the  Compensation  Committee.  No more  than a total  of  20,000,000
         shares of Common Stock are available  for delivery as restricted  stock
         and restricted stock units.

                  Other   Stock-Based   Awards.   The  2004  Plan   permits  the
         Compensation   Committee  to  grant  other  types  of  equity-based  or
         equity-related  awards  (including  the  grant  or  offer  for  sale of
         unrestricted  shares of Common  Stock) in such  amounts  and subject to
         such terms and conditions as the Compensation  Committee may determine.
         Such awards may entail the transfer of actual shares of Common Stock to
         participants  or payment in cash or otherwise  of amounts  based on the
         value of shares of Common Stock.

                  Incentive  Awards.  The 2004  Plan  permits  the  Compensation
         Committee to grant Incentive  Awards in such amounts and subject to the
         achievement of performance  goals and other terms and conditions as the
         Committee  may  determine.   Incentive   awards  will  be  granted  and
         administered  to comply with the  requirements of Section 162(m) of the
         Code. After the term for the applicable  performance  period has ended,
         the  participant  will be  entitled  to  payment  based on the level of
         achievement of the performance goals set by the Compensation Committee.
         The  Compensation  Committee  shall  certify  the  achievement  of  the
         performance goals in writing before the incentive award is settled.  At
         the  discretion  of  the  Compensation  Committee,  the  settlement  of
         incentive  awards may be in cash,  shares of Common  Stock,  or in some
         combination thereof.

                  Tax Offset Bonuses. The Compensation  Committee may grant to a
         participant   specified   amount  for  the  purpose  of  assisting  the
         participant to pay taxes resulting from the grant of an Award.

         Change in Control. The Committee may provide in any award agreement for
provisions relating to a "change in control" of the Company, including,  without
limitation, the acceleration or extension of the exercisability of, or the lapse
of restrictions or deemed satisfaction of goals with respect to, any outstanding
Awards.  Unless otherwise  provided in a participant's  award agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of the  Company  with  or  into  any  other  entity  (the
"successor  entity")  or any  transaction  in which  another  person  or  entity
acquires all of the Company's  issued and  outstanding  Common Stock, or all, or
substantially all, of the Company's assets, outstanding Awards may be assumed or
an equivalent  Award may be substituted  by the successor  entity or a parent or
subsidiary of the successor entity.

         Amendment  of the 2004  Plan.  The Board  may from time to time  alter,
suspend,  discontinue,  revise,  amend or terminate the 2004 Plan in any respect
whatsoever, provided, that no such modification of the 2004 Plan shall adversely
affect in any material  way any award  previously  granted  under the 2004 Plan,
without the written consent of the participant who received such award. However,
the Board may not  amend,  without  stockholder  approval,  the 2004 Plan in any
manner  that  requires   stockholder  approval  pursuant  to  the  Code  or  the
regulations  promulgated  thereunder,  or pursuant to the  Exchange  Act or Rule
16b-3 (or its successor) promulgated thereunder.

         Term of the 2004 Plan.  Unless  terminated  earlier as  provided in the
2004 Plan,  the 2004 Plan will expire on June 22, 2014,  which is ten years from
its  effective  date,  the  date  on  which  it was  approved  by the  Company's
stockholders.



                                       35


Certain Federal Income Tax Consequences

         The following  summary of federal income tax consequences is based upon
existing statutes, regulations and interpretations thereof. The applicable rules
are complex,  and income tax consequences may vary depending upon the particular
circumstances of each plan participant.  This Proxy Statement  describes federal
income  tax  consequences  of  general  applicability,  but does not  purport to
describe either  particular  consequences to each individual plan participant or
foreign,  state or local  income tax  consequences,  which may  differ  from the
United States federal income tax consequences.

         Incentive Stock Options ("ISOs")

         Award;  Exercise.  ISOs are  intended to  constitute  "incentive  stock
options" within the meaning of Section 422 of the Code. ISOs may be granted only
to employees of the Company  (including  directors who are also employees) or an
affiliate.  An optionee does not recognize  taxable income upon either the grant
or  exercise  of an ISO.  However,  the excess of the fair  market  value of the
shares  purchased  upon  exercise  over the option  exercise  price (the "option
spread") is includible in the optionee's  "alternative  minimum  taxable income"
("AMTI") for purposes of the alternative minimum tax ("AMT").  The option spread
is generally  measured on the date of exercise and is  includible in AMTI in the
year of exercise.  Special rules  regarding the time of AMTI inclusion may apply
for  shares  subject  to a  repurchase  right  or  other  "substantial  risk  of
forfeiture"  (including,  in the case of each  person  subject to the  reporting
requirements  of Section 16 of the Exchange  Act, any  limitations  on resale of
shares imposed under Section 16(b) of the Exchange Act).


         Sale of Option Shares.  If an optionee holds the shares purchased under
an ISO for at least two years from the date the ISO was granted and for at least
one year from the date the ISO was exercised, any gain from a sale of the shares
other than to the  Company is taxable as  long-term  capital  gain.  Under these
circumstances,  the Company would not be entitled to a tax deduction at the time
the ISO was  exercised or at the time the stock was sold. If an optionee were to
dispose of stock  acquired  pursuant  to an ISO  before the end of the  required
holding periods (a "Disqualifying Disposition"),  the amount by which the market
value of the stock at the time the ISO was exercised exceeded the exercise price
(or,  if less,  the  amount of gain  realized  on the sale)  would be taxable as
ordinary  income,  and the  Company  would be entitled  to a  corresponding  tax
deduction.  Such income is subject to information reporting  requirements.  Gain
from a  Disqualifying  Disposition  in  excess  of  the  amount  required  to be
recognized as ordinary  income is capital gain, and is  "long-term"  gain if the
shares have been held more than one year as of the date of sale.  Optionees  are
required  to notify  the  Company  immediately  prior to making a  Disqualifying
Disposition.  If stock is sold to the Company rather than to a third party,  the
sale may not produce  capital gain or loss. A sale of shares to the Company will
constitute  a redemption  of such  shares,  which could be taxable as a dividend
unless the redemption is "not  necessarily  equivalent to a dividend" within the
meaning of the Code.


         Exercise with Stock.  If an optionee pays for ISO shares with shares of
the Company  acquired  under an ISO or a qualified  employee stock purchase plan
("statutory option stock"), the tender of shares is a Disqualifying  Disposition
of the  statutory  option  stock if the above  described  (or other  applicable)
holding periods respecting those shares have not been satisfied.  If the holding
periods with respect to the statutory option stock are satisfied,  or the shares
were not  acquired  under a  statutory  stock  option of the  Company,  then any
appreciation  in the  value  of the  surrendered  shares  is  not  taxable  upon
surrender.  Special basis and holding period rules apply where  previously owned
stock is used to exercise an ISO.


         The present position of the Internal Revenue Service ("IRS") appears to
be that  income  and  employment  withholding  taxes  are not  imposed  upon the
exercise of an ISO or the sale of ISO shares.  The IRS is studying this position
and may change it at any time, possibly with retroactive effect.

         Non-qualified Stock Options (NSOs) and Stock Appreciation Rights

         Award;  Exercise.  The grant of  non-qualified  stock options and stock
appreciation rights will not result in income taxable to the employee or provide
a deduction  to the Company.  However,  the  exercise of a  non-qualified  stock
option or a stock  appreciation  right results in taxable  income to the holder,
and the  Company is entitled to a  corresponding  deduction.  At the time of the
exercise  of a  non-qualified  stock  option,  the  amount  so  taxable  and  so
deductible  will be the excess of the fair market value of the shares  purchased
over their option price.  Upon the exercise of a stock  appreciation  right, the
participant will be taxed at ordinary income tax rates on the amount of the cash
and the fair  market  value of the  shares  received  by the  employee,  and the
Company will be entitled to a corresponding deduction.


                                       36


         Sale of Option Shares.  Upon sale, other than to the Company, of shares
acquired under an NSO, an optionee generally will recognize capital gain or loss
to the extent of the  difference  between the sale price and the  optionee's tax
basis in the  shares,  which will be  long-term  gain or loss if the  employee's
holding period in the shares is more than one year. Certain lower rates apply if
the shares  have been held for longer  periods.  If stock is sold to the Company
rather than to a third party,  the sale may not produce  capital gain or loss. A
sale of shares to the Company will constitute a redemption of such shares, which
could be  taxable  as a  dividend  unless  the  redemption  is "not  necessarily
equivalent to a dividend" within the meaning of the Code.


         Exercise with Stock.  If an optionee  tenders  Common Stock (other than
statutory option  stock--see  above) to pay all or part of the exercise price of
an NSO, the  optionee  will not have a taxable  gain or  deductible  loss on the
surrendered  shares.  Instead,  shares  acquired upon exercise that are equal in
value to the fair market value of the shares  surrendered in payment are treated
as if they had been  substituted  for the  surrendered  shares,  taking as their
basis and holding  period the basis and holding  period that the optionee had in
the surrendered shares. The additional shares are treated as newly acquired, are
taxable to the  optionee,  and have a basis equal to their fair market  value on
the exercise date.


         If the surrendered shares are statutory option stock as described above
under  "Incentive Stock Options",  with respect to which the applicable  holding
period  requirements for favorable  income tax treatment have not expired,  then
the newly acquired  shares  substituted  for the statutory  option shares should
remain subject to the federal income tax rules governing the surrendered shares,
but the  surrender  should not  constitute a  Disqualifying  Disposition  of the
surrendered stock.

Restricted Stock Awards and Restricted Stock Units

         Award;  Exercise. A participant who is granted a restricted stock award
or restricted  stock unit will not recognize  taxable income upon the receipt of
such shares or stock units so long as the interest in such shares or stock units
is subject to a "substantial  risk of forfeiture"  within the meaning of Section
83 of the Code.  Upon lapse or release of the  restrictions,  the recipient will
recognize  taxable income at ordinary income tax rates on an amount equal to the
fair market value of the shares or stock units less the amount of any price paid
for the shares or stock units.  The Company will be entitled to a  corresponding
deduction  when the value of the award is  included in the  recipient's  taxable
income.  The basis of  restricted  shares or  restricted  stock units held after
lapse or termination of restrictions will be equal to their fair market value on
the  date  of  lapse  or  termination  of  restrictions,   and  upon  subsequent
disposition  any further gain or loss will be long-term  or  short-term  capital
gain or loss,  depending  upon the length of time the shares or stock  units are
held. A  participant  may elect to be taxed at ordinary  income tax rates on the
full fair market value of the restricted shares or restricted stock units at the
time of transfer.  If the election is not made, the basis of the shares or stock
units  so  acquired  will be  equal  to the  fair  market  value  at the time of
transfer.  If the election is made,  no tax will be payable upon the  subsequent
lapse or release of the restrictions, and any gain or loss upon disposition will
be a capital gain or loss.

         Other Stock Based Awards and Incentive Awards

Award;  Exercise.  A  participant  will realize  ordinary  income as a result of
performance awards at the time Common Stock is transferred or cash is paid in an
amount equal to the value of the shares delivered plus the cash paid.

Option Grants Contingent upon Stockholder  Approval of the Amendment to the 2004
Plan

The  Compensation  Committee has not made or proposed any option grants or other
awards  under the 2004 Plan that will become  effective  subject to  stockholder
approval of this Proposal 5. Option grants from the 2004 Plan during 2004 to the
Named Executive Officers are detailed in the table on page 8 of this Proxy.

Approval Required

         Approval of Proposal 5 requires the  affirmative  vote of a majority of
the outstanding shares of Common Stock of the Company  represented and voting at
the Annual Meeting.

         The  Board  unanimously  recommends  a vote  FOR  the  approval  of the
amendments  to the 2004 Plan.  Proxies  solicited  by the Board will be so voted
unless stockholders specify a different choice in their proxies.


                                       37


          PROPOSAL TO RATIFY THE APPOINTMENT OF REGISTERED INDEPENDENT
                             PUBLIC ACCOUNTING FIRM
                                  (Proposal 6)


      The  Audit  Committee  of the  Board  has  recommended  and the  Board has
appointed  the firm of  Odenberg  Ullakko  Muranishi  & Co.  LLP  ("OUM") as the
independent  registered public accounting firm to audit the financial statements
of the Company for the fiscal year ending  December  31,  2005.  OUM has been so
engaged since December 24, 2003. The Board recommends that  stockholders vote in
favor of ratifying such appointment.

      OUM representatives  are expected to attend the 2005 Annual Meeting.  They
will have an opportunity to make a statement if they desire to do so and will be
available to respond to appropriate stockholder questions.

      We are  asking our  stockholders  to ratify  the  selection  of OUM as our
independent  registered  public  accounting firm.  Although  ratification is not
required by our By-Laws or otherwise,  the Board is submitting  the selection of
OUM to our stockholders for ratification as a matter of good corporate practice.
Even if the selection is ratified, the Audit Committee,  in its discretion,  may
select a different registered public accounting firm at any time during the year
if it  determines  that  such a change  would be in the  best  interests  of the
company and our stockholders.

Approval Required

      Approval of Proposal 6 requires the affirmative  vote of a majority of the
outstanding shares of Common Stock of the Company  represented and voting at the
Annual Meeting.


      The  Board  unanimously  recommends  a vote  FOR the  ratification  of the
appointment of OUM as the  independent  registered  accounting firm to audit the
financial  statements  of the Company for the fiscal  year ending  December  31,
2005.  Proxies  solicited  by the  Board  will be so voted  unless  stockholders
specify a different choice in their proxies.



                                  OTHER MATTERS


Deadline for Receipt of  Stockholder  Proposals  for  Inclusion in the Company's
Proxy Statement for the 2006 Annual Meeting

      Under the rules of the  Securities  and Exchange  Commission,  stockholder
proposals  submitted  for next year's  Proxy  Statement  must be received by the
Company  no later  than the  close of  business  on  February  28,  2006,  to be
considered.  Proposals  should be addressed to:  Secretary,  Calypte  Biomedical
Corporation, 5000 Hopyard Road, Suite 480, Pleasanton, CA 94588.


      Any  stockholder  who  wishes  to  bring a  proposal  before  the  Calypte
Biomedical Corporation 2006 Annual Meeting of Stockholders, but does not wish to
include it in the Company's proxy materials,  must provide written notice of the
proposal to Calypte's Secretary, at the above address, by March 30, 2006.

Other Information

      The Company does not know of any matters  other than those  referred to in
the accompanying Notice of Annual Meeting of Stockholders that may properly come
before the meeting or other matters  incident to the conduct of the meeting.  As
to any other  matter or proposal  that may  properly  come  before the  meeting,
including  voting for the  election  of any  person as a director  in place of a
nominee  named  herein  who  becomes  unable to serve or for good cause will not
serve and voting on a proposal omitted from this Proxy Statement pursuant to the
rules of the  Securities  and Exchange  Commission,  it is intended that proxies
received will be voted in accordance with the discretion of the proxy holders.

      There are no matters on the agenda that  involve  rights of appraisal of a
stockholder.

Information Incorporated By Reference

      The Company  incorporates by reference all items and matters  contained in
its Annual Report on Form  10-KSB/A  (No. 1) for the fiscal year ended  December
31, 2004 and its Quarterly Report on Form 10-QSB for the quarter ended March 31,
2005 each as filed with the Securities and Exchange Commission



                                           By order of the Board of Directors,

                                           /s/ J. Richard George
                                           J. Richard George
                                           President and Chief Executive Officer

Pleasanton, California
June 1, 2005


                                       38


                                                                      Appendix A
                          THE CALYPTE BIOMEDICAL CORPORATION
                             2005 DIRECTOR INCENTIVE PLAN

                                       ARTICLE I

                                        GENERAL

1.1   Purpose.

      The purpose of the Calypte Biomedical  Corporation 2005 Director Incentive
Plan is to attract  and  retain  the best  available  personnel  for  service as
Outside  Directors  (as defined  herein) of the Company and its  Affiliates,  to
provide  additional  incentive  to the Outside  Directors of the Company and its
Affiliates to serve as Directors and to encourage their continued service.

1.2   Definitions of Certain Terms.

      1.2.1       "Affiliate" means a corporation which, for purposes of Section
                  424 of the Code,  is a Parent or  Subsidiary  of the  Company,
                  direct or indirect.

      1.2.2       "Award" means an award made pursuant to the Plan.

      1.2.3       "Award  Agreement"  means the  written  document by which each
                  Award is evidenced.

      1.2.4       "Board" means the Board of Directors of Calypte.

      1.2.5       "Calypte"  means Calypte  Biomedical  Corporation,  a Delaware
                  corporation, and any successor thereto.

      1.2.6       "Certificate"  means a stock certificate (or other appropriate
                  document  or  evidence of  ownership)  representing  shares of
                  Common Stock of Calypte.

      1.2.7       "Code"  means the Internal  Revenue  Code of 1986,  as amended
                  from time to time, and the applicable  rulings and regulations
                  thereunder.

      1.2.8       "Committee"  means the Compensation  Committee of the Board or
                  any successor  thereto or such other committee or subcommittee
                  designated by the Board to  administer  the Plan in accordance
                  with Section 1.3.

      1.2.9       "Common Stock" means common stock of Calypte,  par value $0.03
                  per share.

      1.2.10      "Company" means Calypte.

      1.2.11      "Director"  means a member  of the  Board  or of the  board of
                  directors of an Affiliate.

      1.2.12      "Disability"  means,  unless  otherwise  defined  in an  Award
                  Agreement,   or  as  otherwise   determined  under  procedures
                  established  by the  Committee  for  purposes  of the Plan,  a
                  disability within the meaning of Section 22(e)(3) of the Code.

      1.2.13      "Employee" means any person,  including officers and Directors
                  employed by the Company or an Affiliate.  Neither service as a
                  Director nor payment of a Director's  fee by the Company or an
                  Affiliate will be sufficient,  in and of itself, to constitute
                  "employment" by the Company or by an Affiliate.

      1.2.14      "Exchange Act" means the  Securities  Exchange Act of 1934, as
                  amended  from  time to  time,  and the  applicable  rules  and
                  regulations thereunder.

      1.2.15      "Fair Market Value" means, as of any date, the value of Common
                  Stock determined as follows:

                                       39


      1.2.15.1    If  the  Common  Stock  is  listed  on any  established  stock
                  exchange,  the  NASDAQ  System or a  national  market  system,
                  including  without  limitation,  the National Market System of
                  NASDAQ,  the Fair Market Value of a share of Common Stock will
                  be the closing sales price for such stock (or the closing bid,
                  if no sales are reported) as quoted on that system or exchange
                  (or the system or exchange with the greatest volume of trading
                  in Common Stock) on the day of  determination,  as reported in
                  the Wall  Street  Journal or any other  source  the  Committee
                  considers reliable.

      1.2.15.2    If the Common Stock is not traded as set forth above, the Fair
                  Market  Value  will  be   determined  in  good  faith  by  the
                  Committee,  such  determination  by the Committee to be final,
                  conclusive and binding.

      1.2.16      "Grant  Notice" means the written  notice  evidencing  certain
                  terms and conditions of an Award.  The Grant Notice is part of
                  the Award Agreement.

      1.2.17      "Inside Director" means a Director who is an Employee.

      1.2.18      "Option" means a stock option granted  pursuant to the Plan.

      1.2.19      "Outside  Director,"  for purposes of this Plan only,  means a
                  Director  who  is  not  an  Employee  or a  greater  than  10%
                  stockholder,  directly  or  beneficially  of the Company or an
                  Affiliate.

      1.2.20      "Parent"  means  a  "parent   corporation,"   whether  now  or
                  hereafter existing, as defined in Section 424(e) of the Code.

      1.2.21      "Plan" means the Calypte Biomedical  Corporation 2005 Director
                  Plan, as described  herein and as hereafter  amended from time
                  to time.

      1.2.22      "Subsidiary" means a "subsidiary  corporation," whether now or
                  hereafter  existing,  as  defined  in  Section  424(f)  of the
                  Internal Revenue Code of 1986.

1.3   Administration.

      1.3.1       Subject to Section 1.3.4,  the Plan shall be  administered  by
                  the Board or the  Committee,  whose members shall serve at the
                  pleasure of the Board. To the extent required for transactions
                  under the Plan to qualify for the exemptions  available  under
                  Rule 16b-3  promulgated  under the  Exchange  Act, all actions
                  relating  to Awards to  persons  subject  to Section 16 of the
                  Exchange  Act  may be  taken  by the  Board  or the  Committee
                  composed  of  two  or  more   members,   each  of  whom  is  a
                  "non-employee  director"  within the meaning of  Exchange  Act
                  Rule 16b-3. To the extent required for  compensation  realized
                  from  Awards  under  the  Plan  to be  deductible  by  Calypte
                  pursuant  to Section  162(m) of the Code,  such  Awards may be
                  granted by the Committee composed of two or more members, each
                  of whom is an  "outside  director"  within the meaning of Code
                  Section 162(m).

      1.3.2       Subject to Section  3.2,  the  Committee  shall have  complete
                  control over the administration of the Plan and shall have the
                  authority in its  discretion to (a) exercise all of the powers
                  granted  to it under the Plan,  (b)  construe,  interpret  and
                  implement the Plan and any Award  Agreements,  (c)  prescribe,
                  amend and rescind rules and regulations  relating to the Plan,
                  including  rules  governing its own  operations,  (d) make all
                  determinations  necessary or advisable  in  administering  the
                  Plan,  (e)  correct  any  defect,   supply  any  omission  and
                  reconcile any inconsistency in the Plan, (f) amend the Plan to
                  reflect  changes in applicable  law, (g) amend any outstanding
                  Award Agreement in any respect, including, without limitation,
                  to  accelerate  the time or times at which the  Award  becomes
                  vested,  unrestricted or may be exercised,  waive or amend any
                  goals,  restrictions  or  conditions  set forth in such  Award
                  Agreement,  or impose new goals,  restrictions and conditions,
                  or reflect a change in the grantee's  circumstances  (e.g.,  a
                  change to  part-time  employment  status),  and (h)  determine
                  whether,  to what  extent  and under  what  circumstances  and
                  method or  methods  (1)  Awards  may be (A)  settled  in cash,
                  shares of Common  Stock,  other  securities,  other  Awards or
                  other  property,  (B) exercised or (C) canceled,  forfeited or
                  suspended, (2) shares of Common Stock, other securities, other
                  Awards or other  property,  and  other  amounts  payable  with
                  respect to an Award may be deferred either automatically or at
                  the election of the grantee  thereof or of the Committee,  (3)
                  loans (whether or not secured by Common Stock) may be extended
                  by the Company or an Affiliate  with respect to any Awards and
                  (4) Awards may be settled by Calypte, any of its Affiliates or
                  any of its or their designees.

                                       40





      1.3.3       Actions  of the  Committee  may be  taken  by  the  vote  of a
                  majority of its members.  Any action may be taken by a written
                  instrument signed by a majority of the Committee members,  and
                  action so taken shall be fully as  effective as if it had been
                  taken  by a  vote  at a  meeting.  The  determination  of  the
                  Committee  on all  matters  relating  to the Plan or any Award
                  Agreement  shall  be  final,   binding  and  conclusive.   The
                  Committee  may allocate  among its members and delegate to any
                  person  who  is  not a  member  of  the  Committee  any of its
                  administrative responsibilities.

      1.3.4       No member of the Board or the Committee or any employee of the
                  Company or of an  Affiliate  shall be liable for any action or
                  determination  made in good faith with  respect to the Plan or
                  any Award  thereunder.  Each such person shall be  indemnified
                  and held harmless by Calypte against and from any loss,  cost,
                  liability,  or expense that may be imposed upon or incurred by
                  such person in connection  with or resulting  from any action,
                  suit or  proceeding  to which such person may be a party or in
                  which  such  person  may be  involved  by reason of any action
                  taken or failure act under the Plan or any Award Agreement and
                  against and from any and all amounts paid by such person, with
                  Calypte's  approval,  in settlement  thereof,  or paid by such
                  person in  satisfaction  of any  judgment in any such  action,
                  suit or proceeding against such person,  provided that Calypte
                  shall have the right, at its own expense, to assume and defend
                  the same. The foregoing right of indemnification  shall not be
                  available  to a person to the extent that a final  judgment or
                  other final adjudication  binding upon such person establishes
                  that the acts or omissions  of such person  giving rise to the
                  indemnification  claim  resulted from such person's bad faith,
                  fraud or willful criminal act or omission. The foregoing right
                  of indemnification  shall not be exclusive of any other rights
                  of indemnification to which such persons may be entitled under
                  Calypte's  Certificate of Incorporation or Bylaws, as a matter
                  of law, or otherwise, or any other power that Calypte may have
                  to indemnify such persons or hold them harmless.

1.4   Persons Eligible for Awards.

      1.4.1       Awards under the Plan may be made only to Outside Directors.

      1.4.2       The Plan  shall not  confer  upon any  grantee  any right with
                  respect to continuation of service as a Director or nomination
                  to serve as a Director, nor shall it interfere in any way with
                  any  rights  which the  Director  or the  Company  may have to
                  terminate the Director's relationship with the Company or with
                  an Affiliate at any time.

1.5   Termination of Continuous Status as a Director.

      1.5.1       The  Committee  may  impose  on any Award or the  exercise  or
                  settlement  thereof,  at the date of grant or,  subject to the
                  provisions of Section 3.1,  thereafter,  such additional terms
                  and  conditions  not  inconsistent  with the provisions of the
                  Plan  as  the  Committee  shall  determine,   including  terms
                  requiring forfeiture, acceleration or pro-rata acceleration of
                  Awards in the event of a termination of grantee's  status as a
                  Director.  Except as otherwise determined by the Committee, in
                  the event a grantee's status as a Director  terminates  (other
                  than upon the grantee's death or Disability), all Options that
                  have  not been  exercised  or any  other  Awards  that  remain
                  subject  to a risk of  forfeiture  or which are not  otherwise
                  vested at the time of such  termination  shall  immediately be
                  terminated and cancelled upon such termination.

      1.5.2       Death or  Disability.  Except  as  otherwise  provided  in the
                  applicable Award Agreement,  upon the grantee's  Disability or
                  death, the grantee:

            1.5.2.1     shall forfeit all Awards that have not previously vested
                        or remain subject to a risk of forfeiture; and

            1.5.2.2     shall have one (1) year to exercise the grantee's Awards
                        that are  vested on the date of  Disability  or death if
                        the grantee's  status as a Director is terminated due to
                        the grantee's Disability or death.


                                       41


      1.5.3       Termination  after  Change in  Control.  Except  as  otherwise
                  provided  by  the  Committee  or  in  the   applicable   Award
                  Agreement, if any grantee's status as a Director is terminated
                  by the Company or an  Affiliate  for any reason other than the
                  grantee's  Disability  or death  within six (6) months after a
                  "change  in  control"  as defined  in  Section  3.9,  then all
                  unvested Awards and other Awards  remaining  subject to a risk
                  of  forfeiture  held by such grantee shall become fully vested
                  for  exercise  upon such  termination.  1.5.4 Any  Awards  not
                  exercised  within  the  permissible  period  of time  shall be
                  forfeited   by  the  grantee.   Notwithstanding   any  of  the
                  foregoing,  the grantee shall not be permitted to exercise any
                  Option at a time beyond the initial option term.  1.5.5 Awards
                  granted  under the Plan shall not be affected by any change of
                  service within or among the Company and any Affiliates so long
                  as the  grantee  continues  to be a Director of the Company or
                  any Affiliate,  provided, however, if a grantee's service as a
                  Director by either the Company or an  Affiliate  should  cease
                  (other  than to  become  a  Director  of an  Affiliate  or the
                  Company),  such termination  shall affect the grantee's rights
                  under any Award granted to such grantee in accordance with the
                  terms of the Plan and the applicable Award Agreement.

1.6   Types of Awards Under Plan.

      Awards  may be made under the Plan in the form of (a)  Options,  (b) stock
appreciation  rights, (c) dividend  equivalent rights, (d) restricted stock, (e)
restricted  stock units,  and (f) other  equity-based or  equity-related  Awards
which the Committee determines to be consistent with the purpose of the Plan and
the interests of the Company or an Affiliate.

1.7   Shares Available for Awards.

      1.7.1       Total  shares  available.  Subject to  adjustment  pursuant to
                  Section  1.7.2,  the total  number  of shares of Common  Stock
                  which may be delivered  pursuant to Awards  granted  under the
                  Plan shall be 18,000,000.  If, after the effective date of the
                  Plan,  any  Award is  forfeited  or  otherwise  terminated  or
                  canceled  without the delivery of shares of Common Stock or is
                  settled for cash,  any shares of Common Stock are  surrendered
                  or withheld  from any Award to satisfy a grantee's  income tax
                  or other  withholding  obligations,  or any  shares  of Common
                  Stock  owned by a grantee  are  tendered  to pay the  exercise
                  price of any Award  granted  under the Plan,  then the  shares
                  covered by such  forfeited,  terminated  or canceled  Award or
                  which are equal to the number of shares settled,  surrendered,
                  withheld or tendered shall again become available for transfer
                  pursuant to Awards  granted or to be granted  under this Plan.

      1.7.2       Any shares of Common Stock (a) delivered by Calypte,  (b) with
                  respect  to  which  Awards  are made by  Calypte  and (c) with
                  respect to which Calypte becomes  obligated to make Awards, in
                  each case through the assumption of, or in  substitution  for,
                  outstanding  awards previously  granted by an acquired entity,
                  shall not be  counted  against  the  shares  of  Common  Stock
                  available  for Awards under this Plan.  Shares of Common Stock
                  which may be  delivered  pursuant to Awards may be  authorized
                  but unissued  Common  Stock or  authorized  and issued  Common
                  Stock held in Calypte's treasury or otherwise acquired for the
                  purposes of the Plan.

      1.7.3       Adjustments. The Committee shall have the authority (but shall
                  not be  required)  to  adjust  the  number of shares of Common
                  Stock  authorized  pursuant  to  Section  1.7.1  and to adjust
                  equitably (including,  without limitation, by payment of cash)
                  the  terms  of  any  outstanding  Awards  (including,  without
                  limitation,  the number of shares of Common  Stock  covered by
                  each  outstanding  Award,  the type of  property  to which the
                  Award is  subject  and the  exercise  or  strike  price of any
                  Award), in such manner as it deems appropriate to preserve the
                  benefits or potential  benefits  intended to be made available
                  to  grantees  of Awards,  for any  increase or decrease in the
                  number of issued shares of Common Stock resulting from a stock
                  split, reverse stock split, stock dividend,  spinoff, splitup,
                  combination or  reclassification  of the Common Stock,  or any
                  other event the Committee  determines  in its sole  discretion
                  affects  the   capitalization   of  Calypte.,   including  any
                  extraordinary  dividend or distribution.  After any adjustment
                  made  pursuant to this  Section  1.7,  the number of shares of
                  Common  Stock  subject  to each  outstanding  Award  shall  be
                  rounded to the nearest whole number.

                                       42


      1.7.4       Except as  provided  under the terms of any  applicable  Award
                  Agreement,  there shall be no limit on the number or the value
                  of shares of Common Stock that may be subject to Awards to any
                  individual under the Plan.

      1.7.5       There shall be no limit on the amount of cash,  securities  or
                  other property that may be delivered pursuant to any Award.

                                   ARTICLE II

                             AWARDS UNDER THE PLAN

2.1   Agreements Evidencing Awards.

      Each Award granted under the Plan shall be evidenced by a written document
which shall  contain such  provisions  and  conditions  as the  Committee  deems
appropriate.  The Committee  may grant Awards in tandem with or in  substitution
for any other Award or Awards granted under this Plan or any award granted under
any other plan of the Company or an Affiliate. By accepting an Award pursuant to
the Plan, a grantee thereby agrees that the Award shall be subject to all of the
terms and provisions of the Plan and the applicable Award Agreement.

2.2   No Rights as a Stockholder.

      No grantee of an Award  shall have any of the rights of a  stockholder  of
Calypte with respect to shares  subject to such Award until the delivery of such
shares.  Except as otherwise  provided in Section 1.7.2, no adjustments shall be
made  for  dividends,   distributions  or  other  rights  (whether  ordinary  or
extraordinary,  and whether in cash,  Common  Stock,  other  securities or other
property)  for  which  the  record  date is prior to the date  such  shares  are
delivered.

2.3   Grant of Options.

      The Committee  may grant  Options to purchase  shares of Common Stock from
Calypte,  in such  amounts  and  subject  to such  terms and  conditions  as the
Committee  may  determine.  The price of an  Option  under  this  Plan  shall be
determined in the sole discretion of the Committee;  provided,  however,  if the
Committee  designates an Option as an Incentive  Stock Option,  then such Option
shall be granted only to an employee of the Company or an Affiliate,  shall have
a per share  price not less  than  100% of the Fair  Market  Value of a share of
Common Stock on the date of grant of the Option, and, if granted to a person who
owns capital stock (including stock treated as owned under Section 424(d) of the
Code) possessing more than 10% of the total combined voting power of all classes
of capital  stock of the Company or an  Affiliate  (a "10%  Owner"),  have a per
share  price not less than  110% of the Fair  Market  Value of a share of Common
Stock on the date of grant,  and shall be for a period of not more than 10 years
(five   years  if  the  Grantee  is  a  10%  Owner)  from  the  date  of  grant.
Notwithstanding  designation  as an  Incentive  Stock  Option,  if the shares of
Common Stock subject to a grantee's  Incentive Stock Options  (granted under all
plans of the Company or an Affiliate),  which become  exercisable  for the first
time during any calendar  year,  have a Fair Market Value in excess of $100,000,
the  Options  accounting  for the excess will be treated as  Nonqualified  Stock
Options.  Incentive  Stock  Options  will be taken into  account in the order in
which they were granted, and the Fair Market Value of the shares of Common Stock
will be determined as of the date of grant.

2.4   Stock Appreciation Rights.

      The Committee may grant Stock Appreciation  Rights in conjunction with all
or part of an Option granted under the Plan. In the case of a Nonqualified Stock
Option,  such rights may be granted either at or after the date of grant of such
Option.  In the case of an Incentive  Stock  Option,  such rights may be granted
only at the date of grant  of such  Option.  A Stock  Appreciation  Right  shall
terminate and no longer be exercisable  upon the  termination or exercise of the
related Option. In either case, the terms and conditions of a Stock Appreciation
Right shall be set forth in the Award  Agreement  for the  related  Option or an
amendment thereto.  Stock Appreciation  Rights shall be exercisable only at such
time or times and to the extent  that the  Options to which  they  relate.  Upon
exercise of a Stock  Appreciation  Right, a grantee shall be entitled to receive
an amount equal to the product of (a) the excess of the Fair Market Value of one
share of Common Stock over the exercise price per share specified in the related
Option times (b) the number of shares in respect of which the Stock Appreciation
Right shall have been exercised,  in cash,  shares of Common Stock or both, with
the Committee having the right to determine the form of payment.

                                       43


2.5   Exercise of Options and Stock Appreciation Rights.

      2.5.1 Any  acceptance  by the Committee of a grantee's  written  notice of
exercise of an Option  shall be  conditioned  upon  payment for the shares being
purchased.  Such  payment  may be made in cash or by such  other  method  as the
Committee may from time to time prescribe.

      2.5.2 After receiving payment from the grantee of the full Option exercise
price,  or after  receiving  notice from the grantee of the  exercise of a stock
appreciation  right for which payment will be made by Calypte partly or entirely
in shares of Common Stock,  Calypte shall, subject to the provisions of the Plan
or any Award Agreement, deliver the shares of Common Stock.

2.6   Grant of Dividend Equivalent Rights.

      The Committee may include in the Award Agreement with respect to any Award
a dividend  equivalent  right  entitling the grantee to receive amounts equal to
all or any portion of the  dividends  that would be paid on the shares of Common
Stock covered by such Award if such shares had been  delivered  pursuant to such
Award. The grantee of a dividend equivalent right will have only the rights of a
general  unsecured  creditor of Calypte until payment of such amounts is made as
specified in the applicable  Award  Agreement.  In the event such a provision is
included in an Award  Agreement,  the  Committee  shall  determine  whether such
payments  shall be made in cash,  in shares of Common Stock or in another  form,
whether they shall be  conditioned  upon the exercise of the Award to which they
relate,  the time or times at which they shall be made, and such other terms and
conditions as the Committee shall deem appropriate.

2.7   Grant of Restricted Stock.

      The  Committee  may  grant or offer for sale  restricted  shares of Common
Stock in such amounts and subject to such terms and  conditions as the Committee
shall  determine,   including   restrictions   based  upon  the  achievement  of
Performance Goals,  time-based  restrictions on vesting following the attainment
of the Performance  Goals;  provided,  that such  restrictions  may lapse, if so
determined  by the  Committee,  in the  event of the  Grantee's  Termination  of
Employment due to death,  Disability or Termination of Employment by the Company
or an Affiliate  without Cause. Upon the delivery of restricted shares of Common
Stock,  the grantee shall have the rights of a  stockholder  with respect to the
restricted  stock,  subject to any  restrictions and conditions as the Committee
may include in the applicable Award  Agreement.  In the event that a Certificate
is issued in respect of restricted  shares of Common Stock, such Certificate may
be  registered  in the name of the  grantee  but shall be held by Calypte or its
designated agent until the time the restrictions lapse.

2.8   Grant of Restricted Stock Units.

      The Committee  may grant Awards of restricted  stock units in such amounts
and subject to such terms and  conditions as the Committee  shall  determine.  A
grantee  of a  restricted  stock  unit will  have  only the  rights of a general
unsecured  creditor of Calypte until  delivery of shares of Common Stock or cash
is made as specified in the applicable  Award  Agreement.  On the delivery date,
the grantee of each restricted stock unit not previously forfeited shall receive
one share of Common Stock or cash equal in value to a share of Common Stock or a
combination thereof, as specified by the Committee.

2.9   Grant of Other Stock-Based Awards.

      The  Committee  may grant other types of  equity-based  or  equity-related
Awards  (including the grant or offer for sale of unrestricted  shares of Common
Stock) in such amounts and subject to such terms and conditions as the Committee
shall determine.  Such Awards may entail the transfer of actual shares of Common
Stock to Plan participants,  or payment in cash or otherwise of amounts based on
the value of shares of Common Stock.

                                       44


2.11  Tax Offset Bonuses.

      At the time an  Award is made  hereunder  or at any time  thereafter,  the
Committee may grant to the grantee  receiving  such Award the right to receive a
cash payment in an amount specified by the Committee, to be paid at such time or
times (if ever) as the Award results in compensation income to the grantee,  for
assisting  the  purpose  of the  grantee  to pay  the  resulting  taxes,  all as
determined  by and on such  other  terms  the  Committee,  andconditions  as the
Committee shall determine.

                           ARTICLE III MISCELLANEOUS

3.1   Date of Adoption and Term of Plan.

      The Plan was  adopted  by the  Board on March 7,  2005,  and shall be made
effective  as of  such  date,  subject  to  the  approval  of  the  Plan  by the
stockholders of Calypte.  Unless sooner  terminated by the Board, the Plan shall
terminate on the day before the tenth  anniversary  of the effective date of the
Plan. The Board reserves the right to terminate the Plan at any time;  provided,
however,  that all Awards  made  under the Plan  prior to shall its  termination
remain in  effect  until  such  Awards  have been  satisfied  or  terminated  in
accordance  with the terms and provisions of the Plan and the  applicable  Award
Agreements.

3.2   Amendment of the Plan.

      3.2.1 The Board may from time to time alter, suspend, discontinue, revise,
amend  or  terminate  the  Plan in any  respect  whatsoever,  provided,  that no
termination,  amendment,  or modification of the Plan shall adversely  affect in
any  material  way any Award  previously  granted  under the Plan,  without  the
written consent of the grantee of such Award,  except as otherwise  specifically
permitted in the Plan or such Award Agreement.

      3.2.2 Unless otherwise  determined by the Board,  stockholder  approval of
any suspension, discontinuance,  revision or amendment shall be obtained only to
the extent  necessary to comply with any  applicable  law, rule or regulation or
stock exchange requirement.

3.3   Stockholder Approval.

      The Plan shall be subject to approval by the  stockholders  of the Company
within twelve (12) months after the date the Plan is adopted.  Such  stockholder
approval shall be obtained in the degree and manner  required  under  applicable
state and federal law and any stock exchange rules.

3.4   Tax Withholding.

      3.4.1 As a  condition  to the  delivery  of any  shares  of  Common  Stock
pursuant to any Award or the lifting or lapse of  restrictions  on any Award, or
in  connection  with any other  event  that  gives  rise to a  federal  or other
governmental  tax  withholding  obligation  on the part of Calypte or any of its
subsidiaries or affiliates relating to an Award (including,  without limitation,
FICA tax),  (a)  Calypte  may deduct or  withhold  (or cause to be  deducted  or
withheld) from any payment or  distribution to a grantee whether or not pursuant
to the Plan or (b) the  Committee  shall be entitled to require that the grantee
remit cash to Calypte or any of its subsidiaries or affiliates  (through payroll
deduction or otherwise),  in each case in an amount sufficient in the opinion of
Calypte to satisfy such withholding obligation.

      3.4.2 If the event giving rise to the  withholding  obligation  involves a
transfer of shares of Common Stock,  then, unless the applicable Award Agreement
provides otherwise, at the discretion of the Committee,  the grantee may satisfy
the  withholding  obligation  described  under Section 3.4.1 by electing to have
Calypte withhold shares of Common Stock (which withholding will be at a rate not
in excess of the statutory minimum rate) or by tendering previously owned shares
of Common Stock,  in each case having a Fair Market Value equal to the amount of
tax to be withheld (or by any other  mechanism as may be required or appropriate
to conform with local tax and other rules). For this purpose,  Fair Market Value
shall be  determined as of the date on which the amount of tax to be withheld is
determined  (and Calypte may cause any fractional  share amount to be settled in
cash).

                                       45


3.5   Required Consents and Legends.

      3.5.1 If the Committee  shall at any time  determine  that any consent (as
hereinafter  defined)  is  necessary  or  desirable  as a  condition  of,  or in
connection  with,  the  granting of any Award,  the delivery of shares of Common
Stock or the delivery of any cash,  securities or other property under the Plan,
or the taking of any other action thereunder (each such action being hereinafter
referred to as a "plan  action"),  then such plan action shall not be taken,  in
whole or in part,  unless and until such  consent  shall have been  effected  or
obtained to the full  satisfaction  of the  Committee.  The Committee may direct
that any Certificate evidencing shares delivered pursuant to the Plan shall bear
a legend setting forth such restrictions on transferability as the Committee may
determine  to be necessary or  desirable,  and may advise the transfer  agent to
place a stop order against any legended shares.

      3.5.2 The term  "consent"  as used herein with  respect to any plan action
includes (a) any and all listings,  registrations or  qualifications  in respect
thereof upon any securities exchange or under any federal,  state, or local law,
or law, rule or regulation of a jurisdiction  outside the United States, (b) any
and all written  agreements and  representations  by the grantee with respect to
the  disposition  of  shares,  or with  respect to any other  matter,  which the
Committee  may deem  necessary or desirable to comply with the terms of any such
listing,  registration  or  qualification  or to  obtain an  exemption  from the
requirement  that any such listing,  qualification  or registration be made, (c)
any and all other consents, clearances and approvals in respect of a plan action
by  any  governmental  or  other  regulatory  body  or  any  stock  exchange  or
self-regulatory  agency and (d) any and all consents or authorizations  required
to comply  with,  or  required  to be obtained  under,  applicable  local law or
otherwise  required by the Committee.  Nothing  herein shall require  Calypte to
list, register or qualify the shares of Common Stock on any securities exchange.

3.6   Nonassignability.

      Except to the extent otherwise  expressly provided in the applicable Award
Agreement,  no Award (or any rights and obligations  thereunder)  granted to any
person under the Plan may be sold, exchanged,  transferred,  assigned,  pledged,
hypothecated  or  otherwise  disposed  of  (including  through  the  use  of any
cash-settled  instrument) (each such action being hereinafter  referred to as an
"assignment"),  whether  voluntarily or involuntarily,  other than by will or by
the laws of  descent  and  distribution,  and all such  Awards  (and any  rights
thereunder)  shall be  exercisable  during the life of the  grantee  only by the
grantee or the grantee's legal  representative.  Notwithstanding the immediately
preceding  sentence,  the Committee may permit,  under such terms and conditions
that it deems  appropriate  in its sole  discretion,  a grantee to transfer  any
Award to any person or entity that the Committee so  determines.  Any assignment
in violation  of the  provisions  of this Section 3.6 shall be void.  All of the
terms and conditions of this Plan and the Award Agreements shall be binding upon
any such permitted successors and assigns.

3.7   Requirement of Consent and Notification of Election Under Section 83(b) of
      the Code or Similar Provision.

      No election under Section 83(b) of the Code (to include in gross income in
the year of transfer the amounts  specified  in Code  Section  83(b)) or under a
similar provision of the law of a jurisdiction  outside the United States may be
made unless expressly permitted by the terms of the Award Agreement or by action
of the Committee in writing prior to the making of such  election.  If a grantee
of an Award,  in connection with the acquisition of shares of Common Stock under
the Plan or  otherwise,  is  expressly  permitted  under  the terms of the Award
Agreement or by such Committee  action to make any such election and the grantee
makes the  election,  the grantee  shall notify the  Committee of such  election
within ten (10) days of filing notice of the election with the Internal  Revenue
Service  or  other  governmental  authority,  in  addition  to  any  filing  and
notification required pursuant to regulations issued under Code Section 83(b) or
other applicable provision.

3.8   Change in Control.

      3.8.1 The  Committee  may provide in any Award  Agreement  for  provisions
relating  to a "change in  control"  of Calypte  (as such term is defined by the
Committee  in any such Award  Agreement),  including,  without  limitation,  the
acceleration or extension of the exercisability of, or the lapse of restrictions
or deemed satisfaction of goals with respect to, any outstanding Awards.

                                       46


      3.8.2 Unless otherwise provided in the applicable Award Agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of  Calypte  with or into any  other  entity  ("successor
entity") or any  transaction in which another  person or entity  acquires all of
the issued and outstanding Common Stock of Calypte,  or all or substantially all
of the assets of  Calypte,  outstanding  Awards may be assumed or an  equivalent
Award may be substituted  by such successor  entity or a Parent or Subsidiary of
such successor entity.

3.9   Right of Discharge Reserved.

      Nothing  in the  Plan or in any  Award  Agreement  shall  confer  upon any
grantee the right to  continued  by the Company or an  Employment  Affiliate  or
affect any right which the Company or an Affiliate  may have to  terminate  such
Employment.

3.10     Nature of Payments.

      3.10.1 Any and all grants of Awards and deliveries of Common Stock,  cash,
securities  or other  property  under  the Plan  shall  be in  consideration  of
services  performed  or to be performed  for the Company by the grantee.  Awards
under the Plan may, in the discretion of the Committee,  be made in substitution
in  whole or in part for cash or  other  compensation  otherwise  payable  to an
Employee.

      3.10.2  All  such  grants  and  deliveries   shall  constitute  a  special
discretionary  incentive  payment to the grantee and shall not be required to be
taken into  account in  computing  the amount of salary or  compensation  of the
grantee for the purpose of  determining  any  contributions  to or any  benefits
under any pension, retirement,  profit-sharing, bonus, life insurance, severance
or other  benefit plan of the Company or under any  agreement  with the grantee,
unless the Company specifically provides otherwise.

3.11  Non-Uniform Determinations.

      The Committee's  determinations  under the Plan and Award  Agreements need
not be uniform and may be made by it selectively  among persons who receive,  or
are eligible to receive,  Awards under the Plan (whether or not such persons are
similarly  situated).  Without  limiting the  generality of the  foregoing,  the
Committee  shall be  entitled,  among  other  things,  to make  non-uniform  and
selective  determinations under Award Agreements,  and to enter into non-uniform
and selective Award Agreements, as to (a) the persons to receive Awards, (b) the
terms and  provisions of Awards and (c) whether a grantee's  Employment has been
terminated for purposes of the Plan.

3.12  Other Payments or Awards.

      Nothing  contained  in the  Plan  shall be  deemed  in any way to limit or
restrict  Calypte from making any award or payment to any person under any other
plan, arrangement or understanding, whether now existing or hereafter in effect.

3.13  Plan Headings.

      The headings in this Plan are for the purpose of convenience  only and are
not intended to define or limit the construction of the provisions hereof.

3.14  Governing Law.

      ALL RIGHTS AND  OBLIGATIONS  UNDER THE PLAN AND EACH AWARD AGREEMENT SHALL
BE  GOVERNED  BY AND  CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  STATE OF
DELAWARE, WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS.

3.15  Severability; Entire Agreement.

      If any of the  provisions  of this Plan or any Award  Agreement is finally
held to be invalid, illegal or unenforceable (whether in whole or in part), such
provision  shall be deemed  modified to the extent,  but only to the extent,  of
such invalidity,  illegality or  unenforceability  and the remaining  provisions
shall not be  affected  thereby;  provided,  that if any of such  provisions  is
finally held to be invalid,  illegal,  or  unenforceable  because it exceeds the
maximum  scope  determined  to be  acceptable  to permit  such  provision  to be
enforceable, such provision shall be deemed to be modified to the minimum extent
necessary  to  modify  such  scope in order to make such  provision  enforceable
hereunder. The Plan and any Award Agreements contain the entire agreement of the
parties  with  respect to the subject  matter  thereof and  supersede  all prior
agreements, promises, covenants, arrangements,  communications,  representations
and warranties between them, whether written or oral with respect to the subject
matter thereof.

                                       47


3.16  Waiver of Claims.

      Each  grantee  of an  Award  recognizes  and  agrees  that  prior to being
selected  by the  Committee  to  receive  an Award he or she has no right to any
benefits  hereunder.  Accordingly,  in consideration of the grantee's receipt of
any Award hereunder,  he or she expressly waives any right to contest the amount
of any Award, the terms of any Award  Agreement,  any  determination,  action or
omission  hereunder or under any Award Agreement by the Committee,  Calypte,  or
the Board,  or any amendment to the Plan or any Award  Agreement  (other than an
amendmento  this  Plan or an Award  Agreement  to which  his or her  consent  is
expressly required by the express terms of an Award Agreement).

3.17  No Third Party Beneficiaries.

      Except  as  expressly  provided  therein,  neither  the Plan nor any Award
Agreemenshall confer on any person other than the Company and the grantee of any
Award any rights or remedies thereunder.

3.18  Successors and Assigns of Calypte.

      The terms of this Plan shall be binding  upon and inure to the  benefit of
Calypte and its successors and assigns.

                                       48




                                                                      Appendix B

                       THE CALYPTE BIOMEDICAL CORPORATION
                               2004 INCENTIVE PLAN
                    AMENDED AND RESTATED AS OF MARCH 7, 2005

                                    ARTICLE I

                                     GENERAL

1.1   Purpose.

      The purpose of the Calypte  Biomedical  Corporation 2004 Incentive Plan is
to attract,  retain and  motivate  officers,  employees  (including  prospective
employees),  consultants and others who may perform  services for the Company or
an Affiliate, to compensate them for their contributions to the long-term growth
and profits of the Company or an Affiliate,  and to encourage  them to acquire a
proprietary interest in the success of the Company or an Affiliate.

1.2   Definitions of Certain Terms.

      1.2.1 "Affiliate"  means a corporation  which, for purposes of Section 424
of the Code, is a Parent or Subsidiary of the Company, direct or indirect.

      1.2.2 "Award" means an award made pursuant to the Plan.

      1.2.3 "Award  Agreement" means the written document by which each Award is
evidenced.

      1.2.4 "Board" means the Board of Directors of Calypte.

      1.2.5  "  Calypte"  means  Calypte  Biomedical  Corporation,   a  Delaware
Corporation, and any successor thereto.

      1.2.6  "Cause"  means the causes set forth in any  written  employment  or
services  agreement  between the Company and the grantee or an  Affiliate or the
grantee,  if any,  or, in the  absence  of such an  agreement,  means any of the
following  acts or  circumstances:  (i)  willful  destruction  by the grantee of
Company  or  Affiliate  property  having a material  value to the  Company or an
Affiliate;  (ii) fraud,  embezzlement,  theft, or comparable  dishonest activity
committed by the grantee against the Company; (iii) the Participant's conviction
of or entering a plea of guilty or nolo  contendere to any crime  constituting a
felony or any misdemeanor involving fraud,  dishonesty or moral turpitude;  (iv)
the grantee's breach, neglect,  refusal or failure to discharge, in each case in
any  material  respect,  his or  her  duties  (other  than  due  to  Disability)
commensurate  with his or her title and  function  or failure to comply with the
lawful  directions  of  the  Board;  or  (v)  a  willful  and  knowing  material
misrepresentation by the grantee to the Board.

      1.2.7  "Certificate"  means  a stock  certificate  (or  other  appropriate
document  or  evidence  of  ownership)  representing  shares of Common  Stock of
Calypte.

      1.2.8 "Code" means the Internal Revenue Code of 1986, as amended from time
to time, and the applicable rulings and regulations thereunder.

      1.2.9  "Committee"  means the  Compensation  Committee of the Board or any
successor  thereto or such other  committee or  subcommittee  designated  by the
Board to administer the Plan in accordance with Section 1.3.

      1.2.10 "Common  Stock" means common stock of Calypte,  par value $0.03 per
share.

      1.2.11 "Company" means Calypte.

                                       49


      1.2.12 "Disability" means, unless otherwise defined in an Award Agreement,
or as otherwise  determined  under  procedures  established by the Committee for
purposes of the Plan, a disability within the meaning of Section 22(e)(3) of the
Code.

      1.2.13  "Employment"  means a grantee's  performance  of services  for the
Company, as determined by the Committee. The terms "employ" and "employed" shall
have their correlative meanings.

      1.2.14  Act"  means the  "Exchange  Securities  Exchange  Act of 1934,  as
amended from time to time, and the applicable rules and regulations thereunder.

      1.2.15  "Fair Market  Value"  means,  as of any date,  the value of Common
Stock determined as follows: If the Common Stock is

              1.2.15.1 listed  on any  established stock  exchange,  the  NASDAQ
System or a national market system,  including without limitation,  the National
System of Market  NASDAQ,  the Fair Market Value of a share of Common Stock will
be closing the sales  price for such stock (or the closing  bid, if no sales are
reported) as quoted on that system or exchange  (or the system or exchange  with
the greatest  volume of trading in Common Stock) on the day of  determination,as
reported in the Wall Street Journal or any other source the Committee  considers
reliable.

              1.2.15.2 If the Common Stock is not traded as set forth above, the
Fair  Market  Value  will be  determined  in good faith by the  Committee,  such
determination by the Committee to be final, conclusive and binding.

      1.2.16 "Grant  Notice" means the written notice  evidencing  certain terms
and  conditions  of an Award.  The Grant Notice is part of the Award  Agreement.
Award" means any Award

      1.2.17 "Incentive  granted  contingently on the achievement of Performance
Goals during  Performance  Periods,  expressed in U.S.  currency or Stock or any
combination  Common  thereof,  intended to qualify as  compensation  pursuant to
performance-based Section 162(m) of the Code, as now constituted or subsequently
amended,  or  pursuant  to a successor  provision  of the Code,  and which is so
designated in the applicable Award Agreement.

      1.2.18 "IncentiveStock Option" means an Option that is intended to qualify
for ncome tax treatment special federali pursuant to Sections 421 and 422 of the
Code, as now  constituted or  subsequently  amended,  or pursuant to a successor
provision  of the  Code,  and which is so  designated  in the  applicable  Award
Agreement.

      1.2.19  "Nonqualified  Stock  Option"  means  an  Option  that  is  not an
Incentive Stock Option.

      1.2.20  "Option" means an Incentive  Stock Option or a Nonqualified  Stock
Option or both, as the context requires.

      1.2.21  "Parent"  means a "parent  corporation,"  whether now or hereafter
existing, as defined in Section 424(e) of the Code.'

      1.2.22  "Performance Goals" means objectives for the Company, an Affiliate
or any individual grantee established by the Committee with respect to Incentive
Awards contingently granted under the Plan. The Performance Goals shall be based
on one or more of the following  criteria:  earnings (either in the aggregate or
on a per-share basis),  total stockholder  return,  return on equity,  return on
capital,  net income,  cash flow,  operating  income or profit,  gross revenues,
economic value added, or strategic business criteria.  The levels of performance
required  with  respect to  Performance  Goals may be  expressed  in absolute or
relative levels.

      1.2.23  "Performance   Period"  means  a  set  time  period  during  which
Performance Goals must be met.

      1.2.24  "Plan" means the Calypte  Biomedical  Corporation  2004  Incentive
Plan, as described herein and as hereafter amended from time to time.

      1.2.25  "Subsidiary"  means a  `subsidiary  corporation,"  whether  now or
hereafter existing, as defined in Section 424(f) of the Internal Revenue Code of
1986.

                                       50


      1.2.26  "Termination  of  Employment"  occurs  on the first day on which a
grantee is for any reason no longer  providing  services  to the  Company in the
capacity of an employee, officer or consultant.

1.3   Administration.

      1.3.1  Subject to Section  1.3.4,  the Plan shall be  administered  by the
Board or the Committee,  whose members shall serve at the pleasure of the Board.
To the  extent  required  for  transactions  under the Plan to  qualify  for the
exemptions  available under Rule 16b-3  promulgated  under the Exchange Act, all
actions  relating to Awards to persons subject to Section 16 of the Exchange Act
may be taken by the Board or the Committee composed of two or more members, each
of whom is a  "non-employee  director"  within the meaning of Exchange  Act Rule
16b-3.  To the extent required for  compensation  realized from Awards under the
Plan to be deductible by Calypte  pursuant to Section  162(m) of the Code,  such
Awards may be granted by the Committee composed of two or more members,  each of
whom is an "outside director" within the meaning of Code Section 162(m).

      1.3.2  Subject to Section 3.2, the Committee  shall have complete  control
over the  administration  of the  Plan  and  shall  have  the  authority  in its
discretion to (a) exercise all of the powers  granted to it under the Plan,  (b)
construe,  interpret  and  implement  the Plan  and any  Award  Agreements,  (c)
prescribe,  amend  and  rescind  rules  and  regulations  relating  to the Plan,
including  rules  governing  its own  operations,  (d) make  all  determinations
necessary or advisable in administering the Plan, (e) correct any defect, supply
any omission and reconcile any  inconsistency in the Plan, (f) amend the Plan to
reflect changes in applicable law, (g) amend any outstanding  Award Agreement in
any respect,  including,  without limitation, to accelerate the time or times at
which the Award becomes vested, unrestricted or may be exercised, waive or amend
any goals,  restrictions  or conditions  set forth in such Award  Agreement,  or
impose  new  goals,  restrictions  and  conditions,  or  reflect a change in the
grantee's circumstances (e.g., a change to part-time employment status), and (h)
determine  whether,  to what extent and under what  circumstances  and method or
methods (1) Awards may be (A)  settled in cash,  shares of Common  Stock,  other
securities,  other Awards or other  property,  (B)  exercised  or (C)  canceled,
forfeited or suspended,  (2) shares of Common  Stock,  other  securities,  other
Awards or other property, and other amounts payable with respect to an Award may
be deferred either automatically or at the election of the grantee thereof or of
the  Committee,  (3) loans  (whether  or not  secured  by Common  Stock)  may be
extended  by the  Company  or an  Affiliate  with  respect to any Awards and (4)
Awards may be settled by Calypte,  any of its  Affiliates or any of its or their
designees.

      1.3.3  Actions of the  Committee may be taken by the vote of a majority of
its  members.  Any  action  may be taken by a  written  instrument  signed  by a
majority  of the  Committee  members,  and  action  so  taken  shall be fully as
effective as if it had been taken by a vote at a meeting.  The  determination of
the Committee on all matters  relating to the Plan or any Award  Agreement shall
be final,  binding and conclusive.  The Committee may allocate among its members
and  delegate  to any  person  who is not a member of the  Committee  any of its
administrative responsibilities.

      1.3.4 No member  of the  Board or the  Committee  or any  employee  of the
Company or of an Affiliate shall be liable for any action or determination  made
in good faith with respect to the Plan or any Award thereunder. Each such person
shall be  indemnified  and held  harmless by Calypte  against and from any loss,
cost, liability,  or expense that may be imposed upon or incurred by such person
in  connection  with or resulting  from any action,  suit or proceeding to which
such  person may be a party or in which such person may be involved by reason of
any  action  taken or  failure  act under the Plan or any  Award  Agreement  and
against  and  from  any and all  amounts  paid by such  person,  with  Calypte's
approval,  in settlement  thereof, or paid by such person in satisfaction of any
judgment in any such action,  suit or proceeding  against such person,  provided
that Calypte shall have the right, at its own expense,  to assume and defend the
same. The foregoing right of indemnification  shall not be available to a person
to the extent that a final  judgment or other final  adjudication  binding  upon
such person establishes that the acts or omissions of such person giving rise to
the  indemnification  claim  resulted  from such  person's  bad faith,  fraud or
willful criminal act or omission.  The foregoing right of indemnification  shall
not be exclusive of any other  rights of  indemnification  to which such persons
may be entitled under Calypte's  Certificate of  Incorporation  or Bylaws,  as a
matter  of law,  or  otherwise,  or any other  power  that  Calypte  may have to
indemnify such persons or hold them harmless.

1.4   Persons Eligible for Awards.

      Awards under the Plan may be made to such officers,  employees  (including
prospective  employees),  consultants  and  other  individuals  who may  perform
services for the Company or for an Affiliate, as the Committee may select.


                                       51


1.5   Termination of Employment.

      1.5.1 The  Committee may impose on any Award or the exercise or settlement
thereof,  at the date of grant or,  subject to the  provisions  of Section  3.1,
thereafter,  such  additional  terms and  conditions not  inconsistent  with the
provisions  of the  Plan  as the  Committee  shall  determine,  including  terms
requiring  forfeiture,  acceleration  or pro-rata  acceleration of Awards in the
event of a  Termination  of  Employment.  Except as otherwise  determined by the
Committee,  all Options that have not been  exercised,  or any other Awards that
remain  subject to a risk of forfeiture or which are not  otherwise  vested,  or
which have  outstanding  Performance  Periods,  at the time of a Termination  of
Employment shall be forfeited.

      1.5.2 Awards granted under the Plan shall not be affected by any change of
employment  or other service  within or among the Company and any  Affiliates so
long as the grantee  continues to be an employee or consultant of the Company or
any  Affiliate,  provided,  however,  if a  grantee's  employment  by either the
Company or an  Affiliate  should  cease  (other than to become an employee of an
Affiliate or the Company),  such  termination  shall affect the grantee's rights
under any Award granted to such grantee in accordance with the terms of the Plan
and the applicable Award Agreement.

      1.5.3  Termination for Cause. If a grantee's  Employment is terminated for
Cause,  then all  Options  and other  Awards  that  remain  subject to a risk of
forfeiture  or  which  are not  otherwise  vested  held by  such  grantee  shall
immediately be terminated and cancelled upon Termination of Employment.

      1.5.4 Death,  Disability,  Termination  without Cause. Except as otherwise
provided in the applicable Award Agreement, upon the grantee's death, Disability
or Termination of Employment for any reason other than for Cause, the grantee:

              1.5.4.1 shall forfeit all Awards that have  not previously  vested
or remain subject to a risk of forfeiture;

              1.5.4.2 shall  have thirty  (30) days  to  exercise the  grantee's
Awards that are vested on the  Termination of Employment if such  termination is
for any reason other than the grantee's Disability or death; and

              1.5.4.3 shall have one  (1) year to exercise  the grantee's Awards
that are vested on the date of Disability or death if the grantee's  Termination
of Employment is due to the grantee's Disability or death.

      1.5.5 Termination after Change in Control. Except as otherwise provided by
the Committee or in the applicable Award Agreement,  if any grantee's Employment
is terminated by the Company or an Affiliate for any reason other than for Cause
within six (6) months  after a "change in  control"  as defined in Section  3.7,
then all  unvested  Awards  and  other  Awards  remaining  subject  to a risk of
forfeiture  held by such grantee shall become fully vested for exercise upon the
Termination of Employment.

      1.5.6 Any Awards not exercised within the permissible period of time shall
be forfeited by the grantee.  Notwithstanding any of the foregoing,  the grantee
shall not be  permitted  to  exercise  any Option at a time  beyond the  initial
option term.

1.6   Types of Awards Under Plan.

      Awards  may be made under the Plan in the form of (a)  Options,  (b) stock
appreciation  rights, (c) dividend  equivalent rights, (d) restricted stock, (e)
restricted stock units, (f) other  equity-based or  equity-related  Awards which
the Committee  determines to be consistent  with the purpose of the Plan and the
interests of the Company or an Affiliate, and (g) Incentive Awards. No Incentive
Stock Option (other than an Incentive Stock Option that may be assumed or issued
by Calypte in connection  with a transaction to which Section 424(a) of the Code
applies)  may be granted to a person who is not eligible to receive an Incentive
Stock Option under the Code.

                                       52


1.7   Shares Available for Awards.

      1.7.1 Total shares available. Subject to adjustment pursuant to Section

      1.7.2,  the total  number of shares of Common Stock which may be delivered
pursuant  to  Awards  granted  under  the  Plan  shall be  47,000,000,  of which
20,000,000  shall be available for delivery as restricted  stock and  restricted
stock units. If, after the effective date of the Plan, any Award is forfeited or
otherwise  terminates  or is canceled  without the  delivery of shares of Common
Stock or is settled  for cash,  any shares of Common  Stock are  surrendered  or
withheld from any Award to satisfy a grantee's  income tax or other  withholding
obligations,  or any shares of Common  Stock owned by a grantee are  tendered to
pay the  exercise  price of any Award  granted  under the Plan,  then the shares
covered by such  forfeited,  terminated or canceled  Award or which are equal to
the number of shares  settled,  surrendered,  withheld or  tendered  shall again
become available for transfer  pursuant to Awards granted or to be granted under
this Plan.

      1.7.2 Any  shares  of Common  Stock (a)  delivered  by  Calypte,  (b) with
respect  to which  Awards  are made by  Calypte  and (c) with  respect  to which
Calypte  becomes  obligated to make Awards,  in each case through the assumption
of, or in substitution for, outstanding awards previously granted by an acquired
entity,  shall not be counted  against the shares of Common Stock  available for
Awards under this Plan.  Shares of Common Stock which may be delivered  pursuant
to Awards may be authorized  but unissued  Common Stock or authorized and issued
Common Stock held in Calypte's  treasury or otherwise  acquired for the purposes
of the Plan.

      1.7.3  Adjustments.  The Committee shall have the authority (but shall not
be required) to adjust the number of shares of Common Stock authorized  pursuant
to Section 1.7.1 and to adjust  equitably  (including,  without  limitation,  by
payment  of  cash)  the  terms of any  outstanding  Awards  (including,  without
limitation,  the number of shares of Common  Stock  covered by each  outstanding
Award,  the type of property  to which the Award is subject and the  exercise or
strike price of any Award), in such manner as necessary to preserve the benefits
or potential  benefits intended to be made available to grantees of Awards,  for
any  increase  or  decrease  in the  number  of issued  shares  of Common  Stock
resulting  from a stock split,  reverse stock split,  stock  dividend,  spinoff,
splitup, combination or reclassification of the Common Stock, or any other event
the Committee  determines in its sole discretion  affects the  capitalization of
Calypte,  including  any  extraordinary  dividend  or  distribution.  After  any
adjustment  made  pursuant to this  Section  1.7, the number of shares of Common
Stock  subject to each  outstanding  Award shall be rounded to the nearest whole
number.

      1.7.4 Maximum Awards.  Subject to adjustment as provided in Section 1.7.2,
(a) the maximum  number of shares of Common Stock with respect to which  Options
or stock appreciation  rights may be granted to an individual grantee during any
calendar  year shall equal  8,000,000  shares of Common  Stock,  (b) the maximum
number of shares of Common  Stock  with  respect  to which  restricted  stock or
restricted  stock  units may be  granted  to an  individual  grantee  during any
calendar year shall equal 8,000,000  shares of Common Stock, (c) the total value
of any Incentive Award awarded to an individual grantee during any calendar year
shall  not  exceed  $1,000,000.  Any  shares of Common  Stock (a)  delivered  by
Calypte,  (b) with  respect to which  Awards  are made by  Calypte  and (c) with
respect to which Calypte becomes  obligated to make Awards, in each case through
the assumption of, or in substitution for, outstanding awards previously granted
by an acquired  entity,  shall not be counted against the shares of Common Stock
available  for  Awards  under  this Plan.  Shares of Common  Stock  which may be
delivered  pursuant to Awards may be  authorized  but  unissued  Common Stock or
authorized  and issued  Common  Stock held in  Calypte's  treasury or  otherwise
acquired for the purposes of the Plan.

                                   ARTICLE II
                              AWARDS UNDER THE PLAN

2.1   Agreements Evidencing Awards.

      Each Award granted under the Plan shall be evidenced by a written document
which shall  contain such  provisions  and  conditions  as the  Committee  deems
appropriate.  The Committee  may grant Awards in tandem with or in  substitution
for any other Award or Awards granted under this Plan or any award granted under
any other plan of the Company or an Affiliate. By accepting an Award pursuant to
the Plan, a grantee thereby agrees that the Award shall be subject to all of the
terms and provisions of the Plan and the applicable Award Agreement.

2.2   No Rights as a Stockholder.

      No grantee of an Award  shall have any of the rights of a  stockholder  of
Calypte with respect to shares  subject to such Award until the delivery of such
shares.  Except as otherwise  provided in Section 1.7.2, no adjustments shall be
made  for  dividends,   distributions  or  other  rights  (whether  ordinary  or
extraordinary,  and whether in cash,  Common  Stock,  other  securities or other
property)  for  which  the  record  date is prior to the date  such  shares  are
delivered.

                                       53


2.3   Grant of Options.

The Committee may grant Options to purchase shares of Common Stock from Calypte,
in such amounts and subject to such terms and  conditions  as the  Committee may
determine.  The price of an Option  under this Plan shall be  determined  in the
sole discretion of the Committee; provided, however, if the Committee designates
an Option as an Incentive  Stock Option,  then such Option shall be granted only
to an employee of the Company or an Affiliate,  shall have a per share price not
less than 100% of the Fair Market  Value of a share of Common  Stock on the date
of grant of the  Option,  and,  if granted to a person  who owns  capital  stock
(including  stock treated as owned under Section 424(d) of the Code)  possessing
more than 10% of the total combined voting power of all classes of capital stock
of the Company or an Affiliate (a "10% Owner"),  have a per share price not less
than  110% of the Fair  Market  Value of a share  Stock on the date of of Common
grant,  and shall be for a period of not more than 10 years  (five  years if the
Grantee is a 10% Owner) from the date of grant.  Notwithstanding  designation as
an Incentive Stock Option,  if the shares of Common Stock subject to a grantee's
Incentive  Stock  Options  (granted  under  all  plans  of  the  Company  or  an
Affiliate),  which  become  exercisable  for the first time during any  calendar
year, have a Fair Market Value in excess of $100,000, the Options accounting for
the excess  will be treated  as  Nonqualified  Stock  Options.  Incentive  Stock
Options will be taken into account in the order in which they were granted,  and
the Fair Market Value of the shares of Common Stock will be determined as of the
date of grant.

2.5   Stock Appreciation Rights.

      The Committee may grant Stock Appreciation  Rights in conjunction with all
or part of an Option granted under the Plan. In the case of a Nonqualified Stock
Option,  such rights may be granted either at or after the date of grant of such
Option.  In the case of an Incentive  Stock  Option,  such rights may be granted
only at the date of grant  of such A  Option.  Stock  Appreciation  Right  shall
terminate and no longer be exercisable  upon the  termination or exercise of the
related Option. In either case, the terms and conditions of a Stock Appreciation
Right shall be set forth in the Award  Agreement  for the  related  Option or an
amendment thereto.  Stock Appreciation  Rights shall be exercisable only at such
time or times and to the extent  that the  Options to which  they  relate.  Upon
exercise of a Stock  Appreciation  Right, a grantee shall be entitled to receive
an amount equal to the product of (a) the excess of the Fair Market Value of one
share of Common Stock over the exercise price per share specified in the related
Option times (b) the number of shares in respect of which the Appreciation Right
shall have been exercised,  in cash,  shares of Stock Common Stock or both, with
the Committee having the right to determine the form of payment.

2.5   Exercise of Options and Stock Appreciation Rights.

      2.5.1 Any  acceptance  by the Committee of a grantee's  written  notice of
exercise of an Option  shall be  conditioned  upon  payment for the shares being
purchased.  Such  payment  may be made in cash or by such  other  method  as the
Committee may from time to time prescribe.

      2.5.2 After receiving payment from the grantee of the full Option exercise
price,  or after  receiving  notice from the grantee of the  exercise of a stock
appreciation  right for which payment will be made by Calypte partly or entirely
in shares of Common Stock,  Calypte shall, subject to the provisions of the Plan
or any Award Agreement, deliver the shares of Common Stock.

2.6   Grant of Dividend Equivalent Rights.

      The Committee may include in the Award Agreement with respect to any Award
a dividend  equivalent  right  entitling the grantee to receive amounts equal to
all or any portion of the  dividends  that would be paid on the shares of Common
Stock covered by such Award if such shares had been  delivered  pursuant to such
Award. The grantee of a dividend equivalent right will have only the rights of a
general  unsecured  creditor of Calypte until payment of such amounts is made as
specified in the applicable  Award  Agreement.  In the event such a provision is
included in an Award  Agreement,  the  Committee  shall  determine  whether such
payments  shall be made in cash,  in shares of Common Stock or in another  form,
whether they shall be  conditioned  upon the exercise of the Award to which they
relate,  the time or times at which they shall be made, and such other terms and
conditions as the Committee shall deem appropriate.

                                       54


2.7   Grant of Restricted

      Stock.  The  Committee  may grant or offer for sale  restricted  shares of
Common  Stock in such  amounts and subject to such terms and  conditions  as the
Committee including shall determine,  restrictions based upon the achievement of
Performance Goals,  time-based  restrictions on vesting following the attainment
of the Goals;  provided,  that such  Performance  restrictions  may lapse, if so
determined  by in the  event  of the the  Committee,  Grantee's  Termination  of
Employment due to death,  Disability or Termination of Employment by the Company
or an Affiliate  without Cause. Upon the delivery of restricted shares of Common
Stock,  the grantee shall have the rights of a  stockholder  with respect to the
restricted  subject to stock,  any  restrictions and conditions as the Committee
may include in the applicable In the event that a Certificate  Award  Agreement.
is issued in respect of shares of Common Stock, such restricted  Certificate may
be  registered  in the name of the  grantee  but shall be held by Calypte or its
designated agent until the time the restrictions lapse.

2.8   Grant of Restricted Stock Units.

      The may grant Committee  Awards of restricted  stock units in such amounts
and subject to terms such and  conditions as the Committee  shall  determine.  A
grantee  of a  restricted  stock  unit will  have  only the  rights of a general
creditor of Calypte until delivery of shares of Common  unsecured  Stock or cash
is made as specified in the applicable  Award  Agreement.  On the delivery date,
the grantee of each stock unit not restricted previously forfeited shall receive
one share of Stock Common or cash equal in value to a share of Common Stock or a
combination thereof, as specified by the Committee.

2.9   Grant of Other Stock-Based Awards.

      The  Committee  may grant other types of  equity-based  or  equity-related
Awards  (including the grant or offer for sale of unrestricted  shares of Common
Stock) in such amounts and subject to such terms and conditions as the Committee
Such Awards may entail the transfer of actual shares of shall determine.  Common
Stock to Plan participants,  or payment in cash or otherwise of amounts based on
the value of shares of Common Stock.

2.10  Grant of Incentive Awards.

      The  Committee may grant  Incentive  Awards in such amounts and subject to
the achievement of Performance Goals during Performance  Periods and other terms
and  conditions  as the Committee  shall  determine.  Incentive  Awards shall be
granted and  administered  to comply with the  requirements of Section 162(m) of
the Code. After the applicable  Performance  Period has ended, the grantee shall
be entitled to based on the level payment ofachievement of the Performance Goals
set by the  Committee.  The  Committee  shall  certify  the  achievement  of the
Performance  Goals in writing  before the  Incentive  Award is  settled.  At the
discretion of the the settlement of Incentive Awards may be in Committee,  cash,
shares of Common  Stock,  or in some  combination  thereof,  as set forth in the
Award  Agreement.  If a grantee  is or  demoted  promoted  during a  Performance
Period,  then,  to the  extent  Committee  determines  the that the  Award,  the
Performance  Goals or the  Performance  Period  are no longer  appropriate,  the
hange,  eliminate or cancel the Committee may adjust,c  Award,  the  Performance
Goals or the Performance  Period, as it deems appropriate in order applicable to
make them appropriate and comparable to the initial Award, the Performance Goals
or the Performance Period.

      2.11  Tax Offset Bonuses.

      At the  time an  Award is made  hereunder  or at the any time  thereafter,
Committee may grant to the grantee  receiving  such Award the right to receive a
cash payment in an amount specified by the Committee, to be paid at such time or
times (if ever) as the Award results in compensation income to the grantee,  for
the  purpose  of  assisting  the  grantee  to pay the  resulting  taxes,  all as
determined  by the  Committee,  and on such other  terms and  conditions  as the
Committee shall determine.

                                       55


                                   ARTICLE III
                                  MISCELLANEOUS

3.1   Date of Adoption and Term of Plan

      The Plan was  originally  adopted by the Board on March 2, 2004,  and made
effective as of June 22, 2004.  Unless sooner  terminated by the Board, the Plan
shall terminate on the day before the tenth anniversary of the effective date of
the  Plan.  The Board  reserves  the  right to  terminate  the Plan at any time;
provided,  however, that all Awards made under the Plan prior to its termination
shall remain in effect until such Awards have been  satisfied or  terminated  in
accordance  with the terms and provisions of the Plan and the  applicable  Award
Agreements.

3.2   Amendment of the Plan.

      3.2.1 The Board may from time to time alter, suspend, discontinue, revise,
amend  or  terminate  the  Plan in any  respect  whatsoever,  provided,  that no
termination,  amendment,  or modification of the Plan shall adversely  affect in
any  material  way any Award  previously  granted  under the Plan,  without  the
written consent of the grantee of such Award,  except as otherwise  specifically
permitted in the Plan or such Award Agreement.

      3.2.2 Unless otherwise  determined by the Board,  stockholder  approval of
any suspension, discontinuance,  revision or amendment shall be obtained only to
the extent  necessary to comply with any  applicable  law, rule or regulation or
stock exchange requirement.

3.3   Tax Withholding.

      3.3.1 As a  condition  to the  delivery  of any  shares  of  Common  Stock
pursuant to any Award or the lifting or lapse of  restrictions  on any Award, or
in  connection  with any other  event  that  gives  rise to a  federal  or other
governmental  tax  withholding  obligation  on the part of Calypte or any of its
subsidiaries or affiliates relating to an Award (including,  without limitation,
FICA tax),  (a)  Calypte  may deduct or  withhold  (or cause to be  deducted  or
withheld) from any payment or  distribution to a grantee whether or not pursuant
to the Plan or (b) the  Committee  shall be entitled to require that the grantee
remit cash to Calypte or any of its subsidiaries or affiliates  (through payroll
deduction or otherwise),  in each case in an amount sufficient in the opinion of
Calypte to satisfy such withholding obligation.

      3.3.2 If the event giving rise to the  withholding  obligation  involves a
transfer of shares of Common Stock,  then, unless the applicable Award Agreement
provides otherwise, at the discretion of the Committee,  the grantee may satisfy
the  withholding  obligation  described  under Section 3.2.1 by electing to have
Calypte withhold shares of Common Stock (which withholding will be at a rate not
in excess of the statutory minimum rate) or by tendering previously owned shares
of Common Stock,  in each case having a Fair Market Value equal to the amount of
tax to be withheld (or by any other  mechanism as may be required or appropriate
to conform with local tax and other rules). For this purpose,  Fair Market Value
shall be  determined as of the date on which the amount of tax to be withheld is
determined  (and Calypte may cause any fractional  share amount to be settled in
cash).

3.4   Required Consents and Legends.

      3.4.1 If the Committee  shall at any time  determine  that any consent (as
hereinafter  defined)  is  necessary  or  desirable  as a  condition  of,  or in
connection  with,  the  granting of any Award,  the delivery of shares of Common
Stock or the delivery of any cash,  securities or other property under the Plan,
or the taking of any other action thereunder (each such action being hereinafter
referred to as a "plan  action"),  then such plan action shall not be taken,  in
whole or in part,  unless and until such  consent  shall have been  effected  or
obtained to the full  satisfaction  of the  Committee.  The Committee may direct
that any Certificate evidencing shares delivered pursuant to the Plan shall bear
a legend setting forth such restrictions on transferability as the Committee may
determine  to be necessary or  desirable,  and may advise the transfer  agent to
place a stop order against any legended shares.

                                       56


      3.4.2 The term  "consent"  as used herein with  respect to any plan action
includes (a) any and all listings,  ualification registrations or q s in respect
thereof upon any securities exchange or under any federal,  state, or local law,
or law, rule or regulation of a jurisdiction  outside the United States, (b) any
and all written  agreements and  representations  by the grantee with respect to
the  disposition  of  shares,  or with  respect to any other  matter,  which the
Committeemay  deemnecessary  or  desirable  to comply with the terms of any such
listing,  registration or  qualification or to obtain an exemption from the that
any such listing,  requiremen qualification or registration be made, (c) any and
all other consents,  clearances and approvals in respect of a plan action by any
governmental or other  regulatory  bodyor any stock exchange or  self-regulatory
agency and (d) any and all consents or authorizations required to with, required
to be  obtained  comply  or  under,  applicable  local  law or  required  by the
Committee.  herein  otherwiseNothing  shall require Calypte to list, register or
qualify the shares of Common Stock on any securities exchange.

3.5   Nonassignability.

      Except to the otherwise  provided in extent expressly the applicable Award
Agreement,  no Award (or any rights and obligations  thereunder)  granted to any
person under the Plan may be sold, exchanged,  transferred,  assigned,  pledged,
hypothecated  or  otherwise  disposed  of  (including  through  the  use  of any
instrument) (each such action being hereinafter referred to as cash-settled an ,
whether voluntarily or "assignment") involuntarily, other than by will or by the
laws  and  distribution,  and  all  of  descent  such  Awards  (and  any  rights
thereundeshall be exercisable during the life of the grantee only by the grantee
or the grantee's  legal  representative.  Notwithstanding  the  immediately  the
Committee may  precedingsentencepermit,  under such terms and conditions that it
appropriate in its sole deems discretion, a grantee to transfer any Award to any
person or entity that the Committee so determines.  Any assignment provisions of
this  Section  3.5  shall  be in  violationo  the  void.  All of the  terms  and
conditions of this Plan and the Award  Agreements shall be binding upon any such
permitted successors and assigns.

3.6   Requirement of Consent and Notification of Election Under Section 83(b) of
      the Code or Similar Provision.

      No election under Section 83(b) of the Code (to include in gross income in
the year of transfer the amounts  specified  in Code  Section  83(b)) or under a
similar provision of the law of a jurisdiction  outside the United States may be
made unless expressly permitted by the terms of the Award Agreement or by action
of the Committee in writing prior to the making of such  election.  If a grantee
of an Award,  in connection with the acquisition of shares of Common Stock under
the Plan or  otherwise,  is  expressly  permitted  under  the terms of the Award
Agreement or by such Committee  action to make any such election and the grantee
makes the  election,  the grantee  shall notify the  Committee of such  election
within ten (10) days of filing notice of the election with the Internal  Revenue
Service  or  other  governmental  authority,  in  addition  to  any  filing  and
notification required pursuant to regulations issued under Code Section 83(b) or
other applicable provision.

3.7   Requirement of Notification Upon  Disqualifying  Disposition Under Section
      421(b) of the Code.

      If any  grantee  shall  make any  disposition  of shares  of Common  Stock
delivered  pursuant  to the  exercise of an  Incentive  Stock  Option  under the
circumstances  described  in  Section  421(b) of the Code  (relating  to certain
disqualifying   dispositions),   such  grantee  shall  notify  Calypte  of  such
disposition within 10 days thereof.

3.8   Change in Control.

      3.8.1 The  Committee  may provide in any Award  Agreement  for  provisions
relating  to a "change in  control"  of Calypte  (as such term is defined by the
Committee  in any such Award  Agreement),  including,  without  limitation,  the
acceleration or extension of the exercisability of, or the lapse of restrictions
or deemed satisfaction of goals with respect to, any outstanding Awards.

      3.8.2 Unless otherwise provided in the applicable Award Agreement,  in the
event of a merger,  consolidation,  mandatory  share  exchange or other  similar
business  combination  of  Calypte  with or into any  other  entity  ("successor
entity") or any  transaction in which another  person or entity  acquires all of
the issued and outstanding Common Stock of Calypte,  or all or substantially all
of the assets of  Calypte,  outstanding  Awards may be assumed or an  equivalent
Award may be substituted  by such successor  entity or a Parent or Subsidiary of
such successor entity.

                                       57


3.9   Right of Discharge Reserved.

      Nothing  in the  Plan or in any  Award  Agreement  shall  confer  upon any
grantee the right to  continued  by the Company or  Employment  an  Affiliate or
affect any right which the Company or an Affiliate  may have to  terminate  such
Employment.

3.10     Nature of Payments.

      3.10.1 Any and all grants of Awards and deliveries of Common Stock,  cash,
securities  or other  property  under  the Plan  shall  be in  consideration  of
services  performed  or to be  performed  for the Company or an Affiliate by the
grantee.  Awards under the Plan may, in the discretion of the Committee, be made
in  substitution  in whole or in part for cash or other  compensation  otherwise
payable to an Employee.

      3.10.2  All  such  grants  and  deliveries   shall  constitute  a  special
discretionary  incentive  payment to the grantee and shall not be required to be
taken into  account in  computing  the amount of salary or  compensation  of the
grantee for the purpose of  determining  any  contributions  to or any  benefits
under any pension, retirement,  profit-sharing, bonus, life insurance, severance
or other benefit plan of the Company or an Affiliate or under any agreement with
the grantee, unless the Company or an Affiliate specifically provides otherwise.

3.11  Non-Uniform Determinations.

      The Committee's  determinations  under the Plan and Award  Agreements need
not be uniform and may be made by it selectively  among persons who receive,  or
are eligible to receive,  Awards under the Plan (whether or not such persons are
similarly  situated).  Without  limiting the  generality of the  foregoing,  the
Committee  shall be  entitled,  among  other  things,  to make  non-uniform  and
selective  determinations under Award Agreements,  and to enter into non-uniform
and selective Award Agreements, as to (a) the persons to receive Awards, (b) the
terms and  provisions of Awards and (c) whether a grantee's  Employment has been
terminated for purposes of the Plan.

3.12  Other Payments or Awards.

      Nothing  contained  in the  Plan  shall be  deemed  in any way to limit or
restrict  Calypte from making any award or payment to any person under any other
plan, arrangement or understanding, whether now existing or hereafter in effect.

3.13  Plan Headings.

      The headings in this Plan are for the purpose of convenience  only and are
not intended to define or limit the construction of the provisions hereof.

3.14  Governing Law.

      ALL RIGHTS AND  OBLIGATIONS  UNDER THE PLAN AND EACH AWARD AGREEMENT SHALL
BE  GOVERNED  BY AND  CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  STATE OF
DELAWARE, WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAWS.

3.15  Severability; Entire Agreement.

      If any of the  provisions  of this Plan or any Award  Agreement is finally
held to be invalid, illegal or unenforceable (whether in whole or in part), such
provision  shall be deemed  modified to the extent,  but only to the extent,  of
such invalidity,  illegality or  unenforceability  and the remaining  provisions
shall not be  affected  thereby;  provided,  that if any of such  provisions  is
finally held to be invalid,  illegal,  or  unenforceable  because it exceeds the
maximum  scope  determined  to be  acceptable  to permit  such  provision  to be
enforceable, such provision shall be deemed to be modified to the minimum extent
necessary  to  modify  such  scope in order to make such  provision  enforceable
hereunder. The Plan and any Award Agreements contain the entire agreement of the
parties  with  respect to the subject  matter  thereof and  supersede  all prior
agreements, promises, covenants, arrangements,  communications,  representations
and warranties between them, whether written or oral with respect to the subject
matter thereof.

                                       58


3.16  Waiver of Claims.

      Each  grantee  of an  Award  recognizes  and  agrees  that  prior to being
selected  by the  Committee  to  receive  an Award he or she has no right to any
benefits  hereunder.  Accordingly,  in consideration of the grantee's receipt of
any Award hereunder,  he or she expressly waives any right to contest the amount
of any Award, the terms of any Award  Agreement,  any  determination,  action or
omission  hereunder or under any Award Agreement by the Committee,  Calypte,  or
the Board,  or any amendment to the Plan or any Award  Agreement  (other than an
amendmento  this  Plan or an Award  Agreement  to which  his or her  consent  is
expressly required by the express terms of an Award Agreement).

3.17  No Third Party Beneficiaries.

      Except  as  expressly  provided  therein,  neither  the Plan nor any Award
Agreemenshall confer on any person other than the Company and the grantee of any
Award any rights or remedies thereunder.

3.18  Successors and Assigns of Calypte.

      The terms of this Plan shall be binding  upon and inure to the  benefit of
Calypte and its successors and assigns.

                                       59


                                                                      APPENDIX C

                         CALYPTE BIOMEDICAL CORPORATION
                             AUDIT COMMITTEE CHARTER
                          Restated As of March 7, 2005

INTRODUCTION

The Audit Committee of the Board of Directors  assists the Board of Directors of
Calypte  Biomedical  Corporation  (the  "Company") in  fulfilling  its oversight
responsibilities   relating  to  the  integrity  of  the  financial  statements,
compliance with legal and regulatory  requirements,  the  independent  auditor's
qualifications and independence, the performance of the independent auditor, and
such other duties as directed by the Board of Directors.

While the Audit Committee has the  responsibilities and powers set forth in this
Charter,  it is not the duty of the Audit Committee to plan or conduct audits or
to  determine  that the  Company's  financial  statements  and  disclosures  are
complete and accurate and are in accordance with generally  accepted  accounting
principles and applicable rules and regulations.  This is the  responsibility of
management and the independent auditor.

STRUCTURE AND ORGANIZATION

1. The  committee  will be composed  solely of directors  who have the necessary
experience and  independent of the management of the Company and are free are of
any relationship that may interfere with their exercise of independent  judgment
as a committee all in accordance  with United States member,  Security  Exchange
Commission ("SEC) and American Stock Exchange requirements.

2.  The  committee  will  consist  of at least  three  members  of the  Board of
Directors. Committeemembers and the committee chair serve at the pleasure of the
Board of Directors. All members must be or become financially literate, at least
one member must have accounting or related financial management  expertise,  and
at least one member must be an "audit committee  financial expert" as defined by
SEC rules.

3. A committee member invited to sit on another public Company's audit committee
must notify the  committee.  The  committee  must  determine  whether or not the
committee  member's  service on another  Company's audit  committee  impairs the
directors' ability to serve on the Company's committee.

4. The committee will meet at least four times a year, on a quarterly  basis, or
more frequently as circumstances  require.  A majority of the committee  members
shall be present to constitute a quorum for the  transaction of the  committee's
business.  The  committee  may ask members of management or others to attend the
meetings and provide  pertinent  information  as  necessary.  Meetings may be in
person or by video or telephone conference if necessary.

5. The  committee  is  expected  to maintain  free and open  communication  with
management and the independent auditor.

6. The  committee  has the authority to  investigate  any matter  brought to its
attention and to retain independent legal, accounting or other advisors for this
purpose if  determined  appropriate,  in its sole  judgment.  The  Company  will
provide funding for that purpose as determined by the committee. The committee's
responsibilities include:

GENERAL RESPONSIBILITIES

1. Meet at least  quarterly  with the  independent  auditor  and  management  in
separate  sessions to discuss any matters  that the  committee  or these  groups
believe should be discussed  privately with the  committee.  Provide  sufficient
opportunity  for the  independent  auditor to meet with others in the Company as
appropriate.

2. Regularly report to the Board of Directors on committee matters.

                                       60


3. Review and reassess the adequacy of this Charter  annually and propose to the
Board of Directors any changes to the Charter.

4. Set policies for the Company's hiring of employees or former employees of the
independent  auditor  who  participated  in any  capacity  in the  audit  of the
Company.

5. Prepare a report of the committee in accordance  with SEC  requirements to be
included in the Company's annual proxy statement.

RESPONSIBILITIES RELATED TO THE INDEPENDENT AUDITOR

1. Retain and,  where  appropriate,  terminate the  independent  auditor.  On an
annual basis,  approve the compensation of the independent auditor, and evaluate
the performance of the  independent  auditor.  The  independent  auditor reports
directly to the committee.

2. Review with the  independent  auditor  and  management  the audit plan of the
independent auditor for the current year and the following year.

3.  Establish a policy with respect to the  evaluation and approval of audit and
permittednon-audit services and related fees, to be performed by the independent
auditor.

4. On an annual basis,  discuss and consider the independent  auditor's  written
affirmation  that the auditor is in fact  independent.  Obtain a formal  written
statement from the independent auditor delineating all relationships between the
Company and the  independent  auditor,  actively  engage in  dialogue  regarding
disclosed  relationships  or  services  which may  impact  the  objectivity  and
independence of the independent auditor, and take or recommend that the Board of
Directors take appropriate action in response to the outside auditor's report to
satisfy  itself  of the  outside  auditor's  independence.  The  committee  will
evaluate the  qualifications,  performance  and  independence of the independent
auditor and present its conclusions to the Board of Directors.

5. At the  committee's  discretion,  arrange for the  independent  auditor to be
available  to the full Board of  Directors to help provide a basis for the Board
of Directors' approval of the independent auditor's appointment.

6. Review with the  independent  auditor the matters  relating to the conduct of
the including any problems or audit,  difficulties  encountered in the course of
the  audit  work,  any  restrictions  on the  scope of  activities  or access to
requested information and any significant disagreements with management.

RESPONSIBILITIES  FOR  OVERSIGHT  OF THE QUALITY AND  INTEGRITY  OF  ACCOUNTING,
AUDITING AND REPORTING PRACTICES OF THE COMPANY

1. Discuss the annual and quarterly financial statements,  including disclosures
under  "Management's  Discussion and Analysis of Financial Condition and Results
of Operations," with management and the independent auditor prior to filing. The
committee should meet and discuss each quarterly earnings announcement,  as well
as financial  information  and  earnings  guidance  provided to  analysts,  with
management  (and the  independent  auditor,  if desired)  prior to release.  The
discussion may be done generally, and may include the types of information to be
disclosed and the types of presentations to be made.  These  discussions  should
cover the quality (not just the acceptability) of the financial  reporting,  and
such other matters as the committee deems appropriate.

2.  Review with  management  and the  independent  auditor  critical  accounting
policies,   significant   financial  reporting  issues  and  judgments  made  in
connection with the preparation of the Company's financial statements, including
any significant  changes in the Company's selection or application of accounting
principles.

3. As necessary, discuss with management any significant financial risk exposure
and the steps  management  has taken to  monitor  and  control  such  exposures,
including the Company's risk assessment and risk management policies.

                                       61


4.  Review  with  management  and  the  independent  auditor  the  adequacy  and
effectiveness  of the Company's  disclosure  controls and  procedures,  internal
controls for financial reporting and computerized information systems controls.

PERIODIC RESPONSIBILITIES

1. Review  with  management  any legal and  regulatory  matters  that may have a
material impact on the Company's  compliance policies and financial  statements,
compliance programs.

2. Oversee the Company's  Corporate  Compliance Program and periodically  review
and suggest to management any necessary  improvements in the program.  Establish
procedures  within  the  Corporate  Compliance  Program  for  the  (i)  receipt,
retention and treatment of complaints regarding accounting,  internal accounting
controls or auditing matters,  and (ii)  confidential,  anonymous  submission by
employees of concerns regarding questionable  accounting or auditing matters and
other matters under the Company's Code of Business  Conduct.  From time to time,
meet with the Company's Chief Compliance Officer.

3. Act as the  Company's  Qualified  Legal  Compliance  Committee  ("QLCC")  for
purposes of internal and external  attorney  reporting  under Section 307 of the
Sarbanes-Oxley  Act of 2002.  Establish a procedure  for  confidential  receipt,
retention and consideration of any attorney report to the QLCC.

4. Review and approve  transactions with the Company involving management and/or
members of the Board of Directors and other related party transactions which are
not  otherwise  subject  to the  approval  of the  Compensation  and  Management
Development Committee and would require disclosure under SEC rules.

5. Annually assess the committee's performance.

6.  Perform  such other  functions  assigned by law,  the  Company's  charter or
bylaws, or the Board of Directors.

                                       62


                         CALYPTE BIOMEDICAL CORPORATION
                          5000 HOPYARD ROAD, SUITE 480
                          PLEASANTON, CALIFORNIA 94588

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned hereby appoints J. RICHARD GEORGE and RICHARD D. BROUNSTEIN, and
each of them,  with full power of  substitution,  as the proxy or proxies of the
undersigned to vote all shares of Common Stock of Calypte Biomedical Corporation
which the  undersigned is entitled to vote at the annual meeting of stockholders
of Calypte Biomedical  Corporation to be held at the Four Points Sheraton Hotel,
located at 5115 Hopyard  Road,  Pleasanton,  CA 94588 on June 30, 2005, at 10:00
a.m. local time, and at any  adjournments  or  postponements  thereof,  with all
powers that the undersigned would have if personally present thereat:

                            (CONTINUED ON OTHER SIDE)

                          /*\ FOLD AND DETACH HERE /*\

- --------------------------------------------------------------------------------

Please mark   |X|
your votes
as this

This proxy when properly executed will be voted in the manner directed herein by
the undersigned  stockholder.  If no direction is made, this proxy will be voted
FOR Proposals 1, 2, 3, 4, 5 and 6.




                                                                                           WITHHOLD
                                                             FOR all nominees            AUTHORITY to
                                                        (except as marked to             vote for all
                                                         the contrary below)         nominees listed below
                                                                               
1.    Election of Directors                                      |_|                          |_|

      Roger I.  Gale;  John J.  DiPietro;  Paul E.
      Freiman;  Julius R. Krevans, M.D.; and Maxim
      A.   Soulimov.   (The  Board  of   Directors
      recommends a vote FOR.)

      This proxy will be voted in the  election of
      directors  in the  manner  described  in the
      proxy  statement for the 2005 annual meeting
      of stockholders.  (INSTRUCTION:  To withhold
      authority to vote for one or more individual
      nominees,  write  such  name or names in the
      space provided to the right.)

2.    Proposal to approve  the  issuance of shares          FOR       AGAINST           ABSTAIN
      of  common  stock in excess of 19.99% of the          |_|         |_|               |_|
      outstanding    common    stock   and   price
      adjustments  in  connection  with our  April
      2005  issuance of notes and  warrants.  (The
      Board of Directors recommends a vote FOR.)

3.    Proposal   to  approve   the   issuance   of          FOR       AGAINST           ABSTAIN
      additional   shares  of  common   stock  and          |_|         |_|               |_|
      warrant shares and adjustment of the warrant
      exercise  price in  connection  with amended
      securities  granted to the  investors in our
      May and July 2004 placements.  (The Board of
      Directors recommends a vote FOR.)

4.    Proposal to adopt the Company's 2005 Director          FOR       AGAINST           ABSTAIN
      Incentive  Plan and to authorize  18,000,000           |_|         |_|               |_|
      shares of Common  Stock to be  reserved  for
      Pssuance    thereunder.    (The   Board   of
      Directors recommends a vote FOR.)




5.    Proposal   to  amend   the   Company's   2004          FOR       AGAINST           ABSTAIN
      Incentive   Plan   and   to   authorize   an           |_|         |_|               |_|
      additional 17,000,000 shares of Common Stock
      to be reserved for Pssuance  thereunder;  to
      permit grants to employees,  consultants and
      others  providing  services to affiliates of
      the Company;  and to increase to  20,000,000
      shares the number of shares of Common  Stock
      available for delivery as  restricted  stock
      and restricted stock inits thereunder.  (The
      Board of Directors recommends a vote FOR.)


6.    Proposal   to  ratify  the   appointment   of          FOR       AGAINST           ABSTAIN
      Odenberg Ullakko  Muranishi & Co. LLP as the           |_|         |_|               |_|
      independent   registered  public  accounting
      firm  to  audit  the   Company's   financial
      statements   for  the  fiscal   year  ending
      December 31, 2005.

      (The Board of  Directors  recommends  a vote FOR.)


In their discretion, the proxies are authorized to vote upon such other business
as may properly come before the meeting and at any adjournment or postponement
thereof.

      PLEASE  MARK,  SIGN,  DATE AND RETURN THE PROXY  CARD  PROMPTLY  USING THE
ENCLOSED ENVELOPE.

Signature of Stockholder____________________

Signature if held jointly __________________               Dated: ________, 2005

Please  sign  exactly  as name  appears  above.  When  shares  are held by joint
tenants,  both should sign. When signing as attorney,  executor,  administrator,
trustee or guardian,  please give full title as such. If a  corporation,  please
sign in full corporate name by President or other authorized person.