Exhibit 16.1





September 28, 2005


Securities and Exchange Commission
Washington, D.C. 20549


Ladies and Gentlemen:


We were previously principal accountants for Neoprobe Corporation and, under the
date of March 31, 2005, we reported on the consolidated financial statements of
Neoprobe Corporation as of and for the years ended December 31, 2004 and 2003.
On September 27, 2005, we resigned. We have read Neoprobe Corporation's
statements included under Item 4.01 of its Form 8-K dated September 27, 2005,
and we agree with such statements, except that we are not in a position to agree
or disagree with Neoprobe Corporation's statements that the change was approved
by the Board of Directors and that BDO Seidman LLP was not consulted regarding
the application of accounting principles to a specified transaction or the type
of audit opinion that might be rendered on Neoprobe Corporation's consolidated
financial statements.

Very truly yours,

/s/ KPMG LLP