CERTIFICATION

      I, Robert P. Hickey, certify that:

      1.    I have reviewed this  quarterly  report on Form 10-QSB of SyntheMed,
Inc.;

      2.    Based on my knowledge,  this  quarterly  report does not contain any
untrue  statement of a material fact or omit to state a material fact  necessary
to make the  statements  made,  in light of the  circumstances  under which such
statements  were made, not misleading with respect to the period covered by this
quarterly report;

      3.    Based on my knowledge, the financial statements, and other financial
information  included in this quarterly  report,  fairly present in all material
respects the financial  condition,  results of operations  and cash flows of the
registrant as of, and for, the periods presented in this report;

      4.    The small  business  issuer's  other  certifying  officers and I are
responsible for establishing and maintaining  disclosure controls and procedures
(as defined in Exchange Act Rules 13a-15(e) and 15d-15(e) for the small business
issuer and we have:

            a)    Designed such disclosure  controls and  procedures,  or caused
      such  disclosure   controls  and  procedures  to  be  designed  under  our
      supervision,  to ensure that  material  information  relating to the small
      business issuer, including its consolidated subsidiaries, is made known to
      us by others  within  those  entities,  particularly  during the period in
      which this quarterly report is being prepared;

            b)    Evaluated the  effectiveness  of the small  business  issuer's
      disclosure  controls and  presented in this report our  conclusions  about
      effectiveness of the disclosure controls and procedures,  as of the end of
      the period covered by this report based on such evaluation; and

            c)    Disclosed  in this  report  any  change in the small  business
      issuer's  internal  control over financial  reporting that occurred during
      the small business issuer's most recent fiscal quarter (the small business
      issuer's  fourth fiscal  quarter in the case of an annual report) that has
      materially  affected,  or is reasonably likely to materially  affect,  the
      small business issuer's internal control over financial reporting; and

      5.    The small  business  issuer's other  certifying  officers and I have
disclosed,  based  on our  most  recent  evaluation  of  internal  control  over
financial  reporting,  to the small  business  issuer's  auditors  and the audit
committee  of the  small  business  issuer's  board  of  directors  (or  persons
performing the equivalent function):

            a)    All  significant  deficiencies  in the design or  operation of
      internal control over financial  reporting which are reasonably  likely to
      adversely affect the small business  issuer's ability to record,  process,
      summarize and report financial information; and

            b)    Any fraud,  whether or not material,  that involves management
      or other  employees  who have a  significant  role in the  small  business
      issuer's  ability  to record,  process,  summarize  and  report  financial
      information; and

      6.    The small  business  issuer's other  certifying  officers and I have
indicated in this quarterly report whether or not there were significant changes
in  internal  controls  or in other  factors  that  could  significantly  affect
internal  controls  subsequent  to the  date  of  our  most  recent  evaluation,
including any  corrective  actions with regard to significant  deficiencies  and
material weaknesses.


Dated: October 31, 2005   By: /s/ Robert P. Hickey
                             ---------------------
                             Robert P. Hickey
                             Chief Executive Officer and Chief Financial Officer


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