Exhibit 99.1


FOR IMMEDIATE RELEASE



Investor Contacts:
Richard T. Schumacher, President & CEO                Pressure BioSciences, Inc.
Edward H. Myles, Vice President of Finance & CFO              (508) 580-1818 (T)



                 PRESSURE BIOSCIENCES, INC. TO RESTATE ITS 2005
           FINANCIAL STATEMENTS RELATED TO ACCOUNTING FOR INCOME TAXES

        Results Of Continuing Operations Before Income Taxes Not Affected

West Bridgewater,  MA, May 19, 2006 - Pressure BioSciences,  Inc. (NASDAQ: PBIO)
today announced that it will restate its income tax expense and liability in its
2005 financial statements, primarily to reduce gain from discontinued operations
by approximately $220,000. The Company will also adjust its estimate of deferred
tax assets and  liabilities  primarily  related to the unrealized  gain from its
investment  in  Panacos  Pharmaceuticals,  Inc.,  and  increase  the  income tax
provision from continuing  operations by approximately  $23,000. The restatement
will  not  affect  the  pre-tax  results  of  continuing  operations  previously
reported,  and will be reflected in an amended  Annual Report on Form 10-KSB for
the fiscal year ended December 31, 2005 and an amended  Quarterly Report on Form
10-QSB for the fiscal quarter ended  September 30, 2005. The Company  expects to
file these amended reports as soon as possible.

The Company has completed a review of the tax liability associated with the 2004
sale of assets and certain  liabilities  of the BBI Core  Businesses to SeraCare
Life Sciences, Inc., and has concluded that the tax gain related to discontinued
operations recorded in the third quarter of 2005 was overstated by approximately
$220,000. In connection with the Company's internal tax review, the Company also
reduced by approximately  $60,000 the estimate of deferred tax liability for the
unrealized gain from its investment in Panacos,  and increased by  approximately
$23,000 the income tax provision from continuing  operations.  These adjustments
will  not  change  the  Company's   reported  pre-tax  results  from  continuing
operations,  but income from  continuing  operations  after income taxes for the
fiscal year ended December 31, 2005 will be reduced from approximately  $873,000
to approximately  $850,000.  The Company will amend and restate its year-end and
third quarter 2005  financial  statements to reflect the results of its internal
tax review.


About Pressure BioSciences, Inc.

Pressure  BioSciences,  Inc.  (PBI) is a publicly  traded,  early-stage  company
focused on the development and  commercialization  of a novel technology  called
Pressure  Cycling  Technology  (PCT).  PCT uses cycles of  hydrostatic  pressure
between ambient and ultra-high  levels (up to 35,000 psi and greater) to control
bio-molecular  interactions.  PBI  currently  holds 13 US and 4 foreign  patents
covering multiple  applications of PCT in the life sciences field,  including in
such areas as genomic and proteomic sample preparation,  pathogen  inactivation,
the control of enzymes, immunodiagnostics, and protein purification.



Forward Looking Statements

t 0 0  Statements  contained  in this  press  release  regarding  the  Company's
intentions,  hopes,  beliefs,  expectations  or  predictions  of the  future are
"forward-looking"  statements  within  the  meaning  of the  Private  Securities
Litigation Reform Act of 1995,  including  statements  relating to the Company's
expectations  about the future.  These  statements  are based upon the Company's
current  expectations,  forecasts,  and  assumptions  that are subject to risks,
uncertainties, and other factors that could cause actual outcomes and results to
differ  materially  from those  indicated by these  forward-looking  statements.
These risks,  uncertainties,  and other factors include, but are not limited to:
the risk that the Company's final tax liability  adjustment  related to the sale
of assets and certain liabilities to SeraCare Life Sciences, Inc. in 2004 may be
materially  different than the estimated amount of approximately  $220,000;  the
risk that the Company's final tax liability adjustment related to its investment
in Panacos Pharmaceuticals,  Inc. may be materially different than the estimated
amount of approximately  $60,000; the risk that if the Company's tax returns are
audited  by  tax  authorities,   the  Company's   liability  for  taxes  may  be
substantially  different than anticipated;  the risk that additional adjustments
to the Company's  financial  information in its 2005 Form 10-KSB and Form 10-QSB
for the period  ended  September  30,  2005 may be  required;  the risk that the
Company may not be able to file the amended  Forms 10-KSB and 10-QSB in a prompt
and timely manner;  and the other risks and  uncertainties  discussed  under the
heading  "Risk  Factors" in the  Company's  Annual Report on Form 10-KSB for the
year ended December 31, 2005 and other reports filed by the Company from time to
time with the SEC. The Company  undertakes  no  obligation  to update any of the
information included in this release, except as otherwise required by law.


The  Company's  amended  Annual  Report on Form 10-KSB for the fiscal year ended
December  31,  2005 and amended  Quarterly  Report on Form 10-QSB for the fiscal
quarter  ended  September  30, 2005 will be available on the  Company's  website
shortly  after  they are filed  with the SEC.  Copies of these  reports  will be
furnished by the Company upon request.


           Visit us at our website http://www.pressurebiosciences.com