SCHEDULE 14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934
                              (Amendment No. [4])


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Filed by a Party other than the Registrant  |_|

Check the Appropriate Box:

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      14a-6(e)(2))
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|_|   Soliciting Material Under Rule 14a-12


                           Amarillo Biosciences, Inc.
                (Name of Registrant as Specified in Its Charter)

                  ---------------------------------------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

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            pursuant to Exchange Act Rule 0-11 (Set forth the amount on which
            the filing fee is calculated and state how it was determined):

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      number, or the Form or Schedule and the date of its filing.

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                           AMARILLO BIOSCIENCES, INC.
                            4134 BUSINESS PARK DRIVE
                              AMARILLO, TEXAS 79110


                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                            To Be Held June 22, 2006


TO THE STOCKHOLDERS:

      The Annual  Meeting of  Stockholders  of Amarillo  Biosciences,  Inc. (the
"Company") will be held at Days Inn Hotel East, 1701 East I-40, Amarillo,  Texas
79102, (806) 379-6255,  on the 22nd day of June, 2006 at 10:00 A.M., local time,
for the following purposes:

      1. To elect six Directors to serve until the next Annual Meeting and until
their respective successors are elected and qualify.

      2. To act upon  such  other  business  as may  properly  come  before  the
meeting.

      3. To adjourn the meeting,  if  necessary,  for the purpose of  soliciting
additional votes.


      Only  stockholders of record as of the close of business on April 27, 2006
are  entitled to receive  notice of and to vote at the  meeting.  A list of such
stockholders shall be open to the examination of any stockholder during ordinary
business hours, for a period of ten days prior to the meeting,  at the principal
executive  offices of the Company,  4134  Business Park Drive,  Amarillo,  Texas
79110.

                       By Order of the Board of Directors


                                                   EDWARD L. MORRIS
                                                   Secretary

Amarillo, Texas
June 7, 2006


      If you do not expect to be present at the  meeting,  please  fill in, date
and sign the  enclosed  Proxy and  return it  promptly  in the  enclosed  return
envelope.



                           AMARILLO BIOSCIENCES, INC.
                            4134 BUSINESS PARK DRIVE
                              AMARILLO, TEXAS 79109

                                 PROXY STATEMENT

      The  accompanying  Proxy is  solicited  by and on  behalf  of the Board of
Directors of Amarillo Biosciences, Inc. a Texas corporation (the "Company"), for
use only at the  Annual  Meeting  of  Stockholders  to be held at Days Inn Hotel
East, 1701 East I-40, Amarillo,  Texas 79102, (806) 379-6255, on the 22nd day of
June,  2006, at 10:00 A.M.,  local time, and at any  adjournments  thereof.  The
approximate date on which this Proxy Statement and the  accompanying  Proxy were
first given or sent to security holders was June 7, 2006.

      Each Proxy  executed and returned by a  stockholder  may be revoked at any
time thereafter,  by written notice to that effect to the Company,  attention of
the Secretary, prior to the Annual Meeting, or to the Chairman, or the Inspector
of  Election,  at the  Annual  Meeting,  or by the  execution  and  return  of a
later-dated proxy, except as to any matter voted upon prior to such revocation.

      The Proxies in the accompanying  form will be voted in accordance with the
specifications  made and where no specifications are given, such Proxies will be
voted FOR the nominees for election as directors named herein. In the discretion
of the proxy  holders,  the Proxies will also be voted FOR or AGAINST such other
matters as may properly come before the meeting.  The  management of the Company
is not aware  that any  other  matters  are to be  presented  for  action at the
meeting. Election of directors will be determined by a plurality of the votes of
the  shares of common  stock,  par value $.01 per share  (the  "Common  Stock"),
present in person or  represented by proxy at the Annual Meeting and entitled to
vote. Accordingly,  in the case of shares that are present or represented at the
Meeting for quorum purposes,  not voting such shares for a particular  director,
including by withholding authority on the Proxy, will not operate to prevent the
election of such  director if he  otherwise  receives a plurality  of the votes.
Votes will be counted  manually by an election judge,  who will be the Company's
Secretary  or  an  Assistant  Secretary,  and  who  will  execute  an  affidavit
certifying the vote as to each proposal.

                                VOTING SECURITIES

      The Board of  Directors  has fixed the close of business on April 27, 2006
as the record date for the  determination  of  stockholders  entitled to receive
notice of and to vote at the Annual Meeting. The issued and outstanding stock of
the Company on April 27, 2006  consisted of  21,082,203  shares of Common Stock,
each entitled to one vote. A quorum of the  stockholders  is  constituted by the
presence,  in person  or by  proxy,  of  holders  of  record  of  Common  Stock,
representing a majority of the number of votes entitled to be cast.

                             PRINCIPAL STOCKHOLDERS

      The  following  table  sets  forth the  number  of shares of Common  Stock
beneficially owned as of April 1, 2006, by each person,  other than officers and
directors,  who is known by the Company to own beneficially  more than 5% of the
Company's outstanding Common Stock.

                                       1


Name and Address of Beneficial Owner                 Number of     Percentage
                                                      Shares        of Class
                                                    Beneficially
                                                       Owned
- ------------------------------------------------- ---------------- ------------
Hayashibara Biochemical Laboratories, Inc.          3,290,781            15.6%
2-3 Shimoishii 1 - chome
Okayama 700, Japan

Shares of the Company held by Hayashibara Biochemical Laboratories,  Inc. may be
voted by its  President,  Ken  Hayashibara.  Dispositive  power over such shares
resides with the Board of Directors of Hayashibara Biochemicals, Inc., as it may
be constituted from time to time.

          SECURITY OWNERSHIP OF DIRECTORS AND NAMED EXECUTIVE OFFICERS

      The following  table sets forth the beneficial  ownership of the Company's
stock as of December 31, 2005 by each executive  officer and director and by all
executive officers and directors as a group:

                                     Amount and
                                     Nature of
Name and Address of Owner            Beneficial          Percent of
                                      Ownership         Class Owned

Joseph Cummins
2122 Harrison
Amarillo, TX 79109                  2,025,032(1)            8.9%

Dennis Moore
402 Fish Hatchery
Hamilton, MT  59840                  864,299(2)             3.9%

Katsuaki Hayashibara
2-3, Shimoishii, 1-chome
Okayama, 700 Japan                   912,365(3)             4.2%

Stephen Chen
Floor 7-1, No. 18
Xin Yi Road,  Sec. 5
Taipei, Taiwan                       864,125(4)             3.9%

James Page
103 Clubhouse Lane, #182
Naples, FL  34105                    864,125(5)             3.9%

Thomas D'Alonzo
908 Vance Street
Raleigh, NC 27608                     38,139(6)             .2%

Thomas Ulie
P.O. Box 814
Mercer Island, WA 98040                671,300              3.2%
                                  ------------------------------------

Total Group (all directors and
executive officers - 5 persons)       5,529,946            22.2%

                                       2


(1)   1,788,486 of these shares are exercisable options

(2)   814,125 of these shares are exercisable options

(3)   864,125 of these shares are exercisable options

(4)   814,125 of these shares are exercisable options

(5)   864,125 of these shares are exercisable options

(6)   31,139 of these shares are exercisable options, and 2,000 are owned by his
      children.

                                  PROPOSAL ONE

                              ELECTION OF DIRECTORS

      Six directors will be elected at the meeting to hold office until the next
Annual Meeting of Stockholders and until their respective successors are elected
and qualify. The By-Laws of the Company permit the Board of Directors to fix the
number of  directors  at no less than one nor more than  thirty  persons and the
Board of Directors has fixed the number of directors at six persons. The Proxies
solicited  by this  proxy  statement  may not be voted for a  greater  number of
persons than the number of nominees  named.  It is intended  that these  Proxies
will be voted for the  following  nominees,  but the  holders  of these  Proxies
reserve  discretion  to cast votes for  individuals  other than the nominees for
director named below in the event of the unavailability of any such nominee. The
Company  has  no  reason  to  believe  that  any  of the  nominees  will  become
unavailable  for election.  Set forth below are the names of the  nominees,  the
principal  occupation of each, the year in which first elected a director of the
Company  and  certain  other  information   concerning  each  of  the  nominees.
Abstentions   or  broker   non-votes  on  this  proposal  will  not  affect  the
determination  of a quorum,  but could  cause  one or more  directors  to not be
elected,  as each  nominee  requires the  affirmative  vote of a majority of the
shares  represented  at the  meeting  (in  person  or by  proxy)  in order to be
elected.

      The Board of Directors  unanimously  recommends that the stockholders vote
FOR this proposal.

      The name of, and  certain  information  with  respect  to, all  directors,
executive  officers and all persons nominated or chosen to become a director are
as follows (all of the following have been nominated to serve as directors):

                                       3


  Name and Age                    Director  Principal Occupation for the Past
                                   Since               Five Years
- --------------------------------- -------- ------------------------------------
Joseph Cummins, DVM, PhD           1984    Chairman of the Board of the
(1)(3), 62                                 Company since June 1984. Has
                                           served as President of the Company
                                           since December 1994 and as Chief
                                           Financial Officer since October 1997.
                                           Received a PhD degree in microbiology
                                           from the University of Missouri in
                                           1978 and a doctor of  veterinary
                                           medicine degree from Ohio State
                                           University in 1966.
Stephen Chen, PhD (2)(4)(6), 55    1996    President and Chief Executive
                                           Officer of STC International,
                                           Inc., a health care investment
                                           firm, since May 1992. From August
                                           1989 to May 1992, Director of
                                           Pharmaceutical Research and
                                           Development for the Ciba Consumer
                                           Pharmaceuticals Division of
                                           Ciba-Geigy.
Dennis Moore, DVM (1)(4)(5)(6),    1986    Doctor of veterinary medicine
58                                         since 1972 and was in private
                                           practice from 1972 to 1995.
                                           Management of personal investments
                                           since 1995.
James Page, MD (1)(2)(5), 77       1996    Prior to retiring in 1991 as a
                                           Vice President with Adria
                                           Laboratories, Inc., held various
                                           upper management level positions
                                           with Carter Wallace, Inc., Merck
                                           Sharpe & Dohme Research
                                           Laboratories and Wyeth
                                           Laboratories.
Thomas D'Alonzo, 63               1998 -   A former ABI director, Mr.
                                   2002    D'Alonzo is a seasoned executive
                                           with experience in all major
                                           facets of pharmaceutical
                                           operations: Sales and marketing,
                                           manufacturing, quality assurance,
                                           finance and licensing and
                                           strategic planning. He is
                                           experienced in research intensive
                                           biotech start up and attendant
                                           fundraising activities. Mr.
                                           D'Alonzo has served on the Board
                                           of Directors for Salix
                                           Pharmaceuticals, Inc. since 2000,
                                           Bio-Informatics Group, Inc. since
                                           2002, and Dara BioSciences, Inc.
                                           since 2005. Mr. D'Alonzo has been
                                           retired since 1999, except for the
                                           Board positions shown above.

Thomas Ulie, 57                     ___    Chief Executive Officer of First
                                           Island Capital, Inc. since 1994,
                                           Mr. Ulie is experienced in
                                           investment business, including
                                           investment banking, research,
                                           corporate management, and money
                                           management, and is a Chartered
                                           Financial Analyst and a
                                           Supervisory Analyst (with the
                                           NYSE).  Currently on the Board of
                                           Directors of Gray*Star, Inc., and
                                           Cardiomedics, Inc.

(1)   Member of the Executive Committee.
(2)   Member of the Compensation Committee.
(3)   Member of the Finance Committee.
(4)   Member of the Audit Committee.
(5)   Member of the Administration  Committee for the 1996 Employee Stock Option
      Plan and the Outside Director and Advisor Stock Option Plan
(6)   Member of the Administration Committee for the 2006 Employees Stock Option
      and Stock Bonus Plan.

                                       4


                                  PROPOSAL TWO

AUTHORIZATION  TO VOTE  PROXIES ON OTHER  BUSINESS TO  PROPERLY  COME BEFORE THE
MEETING.

      The Company's  stockholders are being asked to approve the voting of their
Proxies upon other  business to properly  come before the Annual  Meeting.  This
would include the transaction of business properly before any adjournment of the
meeting, subject, however, to approval of proposition 3 (see below).

      Management is not aware of any other  business that will be brought before
the meeting; however, Article I, Section 1 of the Bylaws of the Company provides
that, "Any business may be transacted at an annual meeting,  except as otherwise
provided by law or by these  Bylaws."  Accordingly,  it is possible  that one or
more  stockholders  may  bring  one or more  matters  before  the  meeting,  and
management  wishes to be able to vote duly executed  Proxies on any such matters
brought  before the meeting.  Abstentions  or broker  non-votes on this proposal
will not affect the determination of a quorum,  but could cause this proposal to
fail, as in order to pass,  this  proposal  requires the  affirmative  vote of a
majority of the shares represented at the meeting (in person or by proxy).

      The Board of Directors  unanimously  recommends that the stockholders vote
FOR this proposal.

                                   PROPOSAL 3

               ADJOURNMENT OF MEETING TO SOLICIT ADDITIONAL VOTES

      The  stockholders  are being asked to approve the voting of their  Proxies
for the purpose of adjourning the meeting to solicit additional votes. It is not
certain  that  the  meeting  will  have to be  adjourned,  but  management  does
anticipate the possibility that sufficient  Proxies may not be received prior to
the meeting date to  constitute a quorum,  and in that event,  management  would
like the authority for the Board of Directors to vote the Proxies to adjourn the
meeting from time to time as may be necessary to solicit  additional  votes,  so
that the annual  meeting  may be properly  held,  and so that  directors  may be
elected for the ensuing year.  Abstentions or broker  non-votes on this proposal
will not affect the determination of a quorum,  but could cause this proposal to
fail, as in order to pass,  this  proposal  requires the  affirmative  vote of a
majority of the shares represented at the meeting (in person or by proxy).

      The Board of Directors  unanimously  recommends that the stockholders vote
FOR this proposal.

Compliance with Section 16(a) Beneficial Ownership Reporting Compliance

      Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended (the
"Exchange  Act") requires  directors and officers of the Company and persons who
own  more  than 10  percent  of the  Company's  Common  Stock  to file  with the
Securities  and  Exchange  Commission  (the  "Commission")  initial  reports  of
ownership  and reports of changes in ownership of the Common  Stock.  Directors,
officers and more than 10 percent  shareholders are required by the Exchange Act
to furnish the Company with copies of all Section 16(a) forms they file.

      To the Company's knowledge, based solely on a review of the copies of such
reports  furnished  to the  Company and  written  representations  that no other
reports were  required  during the year ended  December  31,  2005,  all filings
applicable to its directors, officers and more than 10 percent beneficial owners
were timely filed.

                                       5


Board of Directors

      The Board of  Directors  has the  responsibility  for  establishing  broad
corporate policies and for the overall  performance of the Company,  although it
is not involved in day-to-day  operating details.  Members of the Board are kept
informed of the Company's business by various reports and documents sent to them
as well as by  operating  and  financial  reports  made at Board  and  Committee
meetings.  Three  meetings of the Board of Directors  were held during 2005.  No
incumbent  director  attended  fewer  than 75% of the  meetings  of the Board of
Directors or meetings of Committees of the Board on which they served.

      Ten times  during  2005,  the Board of  Directors  conducted  business  by
unanimous written consent, in lieu of holding a meeting.

Audit, Nominating, and Compensation Committees

      The Company has standing Audit, Nominating, and Compensation Committees of
the  Board  of  Directors   established  in  accordance   with  15  U.S.C.   ss.
78c(a)(58)(A).

Audit Committee Report

      The Audit Committee has reviewed and discussed with management the audited
financial  statements  included in the Company's  Form 10-KSB for the year ended
December  31,  2005,  a copy of  which is  included  in the  Proxy  solicitation
materials sent to each stockholders. The Audit Committee has also discussed with
the  independent  auditors  the  matters  required  to be  discussed  by  SAS 61
(codification  of  statements  on  auditing  standards,   AU  Section  380),  as
heretofore  modified or  supplemented.  The Audit  Committee  has  received  the
written disclosures and the letter from the independent  accountants required by
Independence   Standards  Board  Standard  No.  1,  as  heretofore  modified  or
supplemented,   and  has  discussed  with  the  independent   accountants,   the
independent  accountants'  independence.  Based  upon the  aforesaid  review and
discussions,  the Audit Committee has recommended to the Board of Directors that
the audited  financial  statements be included in the Company's Annual Report on
Form 10-KSB for the fiscal year ended December 31, 2005.

Stephen Chen  Katsuaki Hayashibara  Dennis Moore

      The Board of  Directors  has not  adopted a written  charter for the Audit
Committee.

      The Audit  Committee  consists of Stephen Chen,  Katsuaki  Hayashibara and
Dennis Moore. All members of the Audit Committee are "independent"  according to
the  definition  of  "independent  director"  set forth in NASD Rule  4200.  The
function  of the Audit  Committee  is to serve as an advisory  committee  to the
Board of Directors  of the Company;  to review  financial  statements  and other
reports prepared by the Company and any reports or other communications rendered
by the Company's  independent  certified  public accounts and to coordinate with
the accountants any matters raised from time to time by the accountants; to meet
with  the   representative  of  the  Company's   independent   certified  public
accountants at least annually; and to take under advisement any matters referred
by the accountants. The Audit Committee met one time during 2005.

                                       6


      The Board of  Directors  created a  Nominating  Committee  on February 26,
2005. The Nominating  Committee does not have a charter.  Current members of the
Nominating  Committee are Joseph M. Cummins,  Katsuaki  Hayashibara,  and Dennis
Moore.  The  function  of the  Nominating  Committee  is to  nominate a slate of
directors to stand for  election as  Directors  of the Company at the  Company's
annual shareholders meeting. The nominees set forth in these Proxy Materials for
election as directors were proposed by the Nominating  Committee,  and nominated
by the Board of Directors of the Company.  The Committee will consider  nominees
recommended by security  holders for election to the Board of Directors in 2006,
and subsequent years.  Security holders shall follow the following procedures in
submitting  recommendations for nominees to the Board of Directors: the proposed
nominee's name,  address,  telephone number,  employer,  present  occupation and
general  business or scientific  qualifications  shall be mailed or faxed to the
Company, in written form. The Nominating Committee will review such submissions,
and if they  determine  that the Company  would benefit by having such person on
its Board of Directors, the Nominating Committee will send to the nominee a more
detailed  Questionnaire,  which will  solicit from said  nominee  relevant  data
required by rules and regulations of the Securities and Exchange Commission, and
other data or  information  which they deem to be material.  Upon receipt of the
completed  Questionnaire,  the Nominating  Committee  will determine  whether to
include such persons among the nominees  recommended by the Nominating Committee
for election as a director at the ensuing annual shareholders meeting.

      The Nominating  Committee believes that for a nominee to be recommended by
the Nominating Committee for election as a Director, the nominee should meet the
following  minimum  qualifications,  and should  possess the following  specific
qualities or skills: each nominee should be of good reputation,  and should have
substantial  experience either in the biotech or a biotech-related  industry, or
in corporate  finance and  accounting,  including  without  limitation,  capital
formation. The Nominating Committee identifies and evaluates nominees based upon
recommendations  from the Company's  officers,  directors and stockholders,  and
such process  includes review of biographical  data,  solicitation of references
and  recommendations,  and  personal  interviews.  A  nominee  for  director  is
evaluated in the same manner, regardless of whether he has been recommended by a
security holder, by management, or by an existing director.

      Joseph  Cummins is the Chief  Executive  Officer of the Company and not an
"independent"  member of the Nominating  Committee under NASD Rule  4200(a)(15).
Dennis Moore and Katsuaki  Hayashibara are independent members of the Nominating
Committee under Rule 4200(a)(15).

      The  Compensation  Committee  consists of Stephen Chen and James Page. The
function of the Compensation  Committee is to serve as an advisory  committee to
the Board of Directors of the Company regarding all matters of director, officer
and employee compensation,  and to report to the Board of Directors from time to
time as they might deem necessary, with any recommendations for changes in level
of  compensation or fringe  benefits for officers,  directors or employees.  The
Compensation Committee met one time in 2005.

      Katsuaki  Hayashibara has declined to stand for reelection to the Board of
Directors of the Company,  and the Board of Directors  will select a replacement
for him on the Audit Committee and Nominating  Committee,  at the annual meeting
of the Board of Directors.

      The Company has a process for Security Holders to send  communications  to
the Board of Directors.  Specifically, all Security Holder communications to the
Board are sent directly to each board member.  Any communication  addressed to a
specific  board  member  is  sent  directly  to  that  board  member,   and  any
communication  directed to "the Board," "the Board of Directors," or "Directors"
in general, is sent to each director then serving.

      The Company strongly  encourages,  but does not require, the attendance of
each director at each Annual Meeting.  Only one director  attended the Company's
2005 Annual Meeting, but four of the five then incumbent directors  participated
in the 2005 Annual  Meeting of Directors,  which  immediately  followed the 2005
Annual Meeting of stockholders,  with three (3) of said directors  participating
in said meeting by conference telephone.  Management has made an effort to clear
this year's Annual Meeting date with all of the directors, and each director and
director  nominee  is  expected  to  attend,  with  the  exception  of  Katsuaki
Hayashibara, who has declined to stand for reelection to the Board of Directors.

                                        7


                  DIRECTORS' FEES AND COMPENSATION DURING 2005

                                                                     Security
                                           Cash Compensation          Grants
                                        -------------------------  -------------
Name                                    Meeting      Consulting      Number of
                                         Fees (1)     Fees (2)      Securities
                                                                     Underlying
                                                                      Options
- -------------------------------------   -----------  ------------  -------------
Stephen Chen, Ph.D.                             --            --         600,000
Katsuaki Hayashibara                            --            --         600,000
Dennis Moore, D.V.M.                            --            --         600,000
James Page, M.D.                                --            --         600,000
Dr. Joseph M. Cummins                           --            --         600,000

(1)   Directors  do  not  receive  compensation  for  attendance  at  directors'
      meetings,  but may claim reimbursement for actual  out-of-pocket  expenses
      incurred in connection with their attendance at such meetings.
(2)   Each  director  may  receive  $1,200  per day for  employment  on  special
      projects or assignments, prorated for partial days.

                             EXECUTIVE COMPENSATION

      The following table presents the  compensation  paid by the Company to the
named executive officers for 2003 through 2005.

                           Summary Compensation Table
                                                                      Long Term
                                         Annual Compensation        Compensation
                                    --------------------------------------------
Name and Principal                                          Other     Securities
                                                           Compen-    Underlying
Position                     Year     Salary     Bonus     sation       Options
- --------------------------  ------  ----------  -------  -----------  ----------
Dr. Joseph M. Cummins,
  Chairman of the Board,
  President and Chief
  Executive Officer         2005     $177,000   $   --    $     --       600,000
                            2004     $ 74,716   $   --    $     --       650,000
                            2003     $103,779   $   --    $     --       490,000


                                       8



                              Option Grants in 2005

      The  following  table sets forth certain  information  relating to options
granted in 2005 to the executive  officers  named above,  to purchase  shares of
common stock of the Company.

                           % of Total
                            Number of        Options
                            Shares of        Granted     Exercise
                             Common            to        or Base
Name                         Stock          Employees     Price      Expiration
                           Underlying        in 2005     ($/Sh)         Date
- ------------------------- --------------- ------------ ------------ ------------
Joseph M. Cummins            100,000          7.7%       $0.40(1)    02/25/2010
                             500,000         38.5%       $0.30(1)    08/22/2010
- ------------------------- --------------- ------------ ------------- -----------

(1)   The fair market value of the common stock on the date of the grant.

                Aggregated Option Exercises at December 31, 2005
                           And Year-End Option Values

      The following  table sets forth  information  for the  executive  officers
named  above,  regarding  the  exercise of options  during 2005 and  unexercised
options held at the end of 2005.



                                                        Number of Shares of Common Stock       Value of Unexercised
                            Shares                      Underlying Unexercised Options at          In-The-Money
                           Acquired on      Value            December 31, 2005 (#)                   Options at
Name                      Exercise (#)    Realized        Exercisable/Unexercisable             December 31, 2005 ($) (1)
                                            ($)                                              Exercisable/Unexercisable
- -----------------------  --------------  -----------  ---------------------------------   --------------------------------
                                                                              
Joseph Cummins                    --            --        1,788,486   /       None           $769,049  /      None
- -----------------------  --------------  ----------   ---------------------------------   --------------------------------


(1)   Calculated  based on the  closing  price of the  common  stock  ($0.43) as
      reported by OTC BB on December 30, 2005.

                              CERTAIN TRANSACTIONS

Hayashibara Biochemical Laboratories, Inc. ("HBL")

      The Company has relied  significantly  on HBL, the largest  shareholder of
the Company,  for a substantial  portion of both its capital and product  supply
requirements, and currently is party to six (6) material agreements with HBL:

      1. Joint  Development and Manufacturing / Supply Agreement dated March 13,
1992.  This  agreement  has been amended on January 7, 1996,  May 10, 1996,  and
September  7,  2001,  and will  expire  March 12,  2008,  at which  time it will
automatically  renew for an additional  three (3) years unless the parties agree
otherwise.  This  agreement  provides the Company with a source of natural human
interferon alfa for use in the Company's  interferon  alfa-containing  products.
Additional  information on the development  agreement is set forth in footnote 4
to the consolidated  financial  statements  accompanying to the 10-KSB.  Neither
party has paid the other any amounts  under this  Agreement  during the past two
(2) years

      2. Japan Animal  Health  License  Agreement  dated  January 20, 1993.  The
original  term of  this  agreement  expired  January  19,  2000,  but  has  been
automatically  renewed for successive  three (3) year terms since that date, and
will currently  expire January 19, 2009,  subject to prior written  agreement of
the parties. The agreement licenses to HBL certain company technical information
and patents,  in  connection  with the oral use of HBL  interferon in animals in
Japan.  Under this  agreement,  HBL pays the Company a royalty of 8% on sales of
HBL  interferon  for oral use in animals in Japan.  The amount  received  by the
Company from such royalties since January 1, 2004, is $42,134,  all of which was
received in 2005.

                                       9


      3.  Manufacturing  / Supply  Agreement  dated June 1,  1994,  subsequently
amended May 10, 1996. This  manufacturing and supply agreement  provides for the
supply of  interferon by HBL to the Company for non-oral  administration  in all
species.  The current  expiration date of this agreement is May 31, 2009,  after
which time the agreement will  automatically  renew for successive five (5) year
periods,  subject to the agreement of the parties.  The Company is not currently
either  acquiring  from HBL nor  reselling  to any other party,  interferon  for
non-oral administration in any species.

      4. Distribution Agreement dated September 17, 1997 (TNF-a). This agreement
provides  for the  acquisition  of the Company of tumor  necrosis  factor  alpha
(TNF-a)  from HBL, and the resale by the Company of TNF-a  containing  products,
subject to payment of certain transfer fees, license fees, and manufacturing and
supply fees to HBL. The agreement will expire  September 16, 2007,  whereupon it
will  automatically  renew for successive three (3) year terms unless one of the
parties gives written notice of  termination to the other prior to  commencement
of the renewal term. The Company is not currently purchasing TNF-a from HBL, nor
has it done so during the past two (2) years.

      5. Distribution Agreement dated September 17, 1997 (INF-g). This agreement
was amended April 4, 2000,  and provides for the  acquisition  by the Company of
interferon  gamma  (INF-g)  from HBL,  and the  resale by the  Company  of INF-g
containing products,  subject to payment of certain transfer fees, license fees,
and  manufacturing  and supply fees to HBL. The agreement will expire  September
16, 2010,  whereupon it will  automatically  renew for successive three (3) year
terms unless one of the parties gives written notice of termination to the other
prior  to  commencement  of the  renewal  term.  The  Company  is not  currently
purchasing INF-g from HBL, nor has it done so during the past two (2) years.

      6.  Distribution  Agreement  dated October 13, 2000 (ACM).  This agreement
provides for the  acquisition  of the Company of anhydrous  crystalline  maltose
(ACM)  from HBL,  and the  resale by the  Company  of ACM  containing  products,
subject to payment of certain transfer fees, license fees, and manufacturing and
supply fees to HBL. The agreement  expired  October 12, 2005, and since then has
automatically  renewed for successive one (1) year terms,  with the current term
to  expire  October  12,  2006.  Thereafter,  the  agreement  will  continue  to
automatically renew for successive one (1) year terms, unless one of the parties
gives written  notice of  termination to the other party within thirty (30) days
prior to the  commencement  of the renewal  term.  The Company is not  currently
purchasing ACM from HBL, nor has it done so during the past two (2) years.


Loans from HBL.

      HBL  loaned  $1  million  to the  Company  on  November  30,  1999  and an
additional $1 million on February 29, 2000, both loans bearing  interest at 4.5%
per annum.  The November 30, 1999 loan has been extended until December 2006 and
the February 29, 2000 loan has been extended to February 29, 2007. The aggregate
balance on both notes at December  31,  2005,  including  principal  and accrued
interest,  was $2,510,701.  The Company  considers those loans,  and the related
extensions therein discussed,  to be of considerable benefit to the Company, and
to be on terms  more  favorable  than  could  be  obtained  from an  independent
institutional lender, or from a non-related third party.


SandersBaker, P.C.

      During  2005,  the Company  used the law firm of  SandersBaker,  P.C.  Mr.
Edward Morris,  Secretary of the Company, is a partner in that firm. The Company
was invoiced $20,354 by said firm in 2005.

                                       10


                         INDEPENDENT PUBLIC ACCOUNTANTS

      Lopez,  Blevins, Bork & Associates,  LLP, of Houston,  Texas, serve as the
Company's  independent  public  accountants.   The  accountants  are  given  the
opportunity  each  year  (including  2006) to have  one or more  representatives
attend the Company's  Annual Meeting,  and to make a statement if they desire to
do so. The Company has not been  notified that said  accounting  firm intends to
have  one or more  representatives  present  at the  2006  Annual  Meeting,  and
accordingly,  it is not anticipated that such  representatives will be available
to respond to questions.

      Through  2003,   Carlos  Lopez,   the  Company's   principal   independent
accountant,  was employed by Malone & Bailey,  PLLC,  who prepared the Company's
audited financials for the year ending December 31, 2003. During 2004, Mr. Lopez
shifted his employment to Lopez, Blevins,  Bork & Associates,  LLP, and in order
to retain the services of Mr. Lopez,  the Company changed its public  accounting
firm to said firm. Accordingly,  during the Company's two (2) most recent fiscal
years, no former accountant has resigned,  declined to stand for reelection,  or
been dismissed.

      The following  summarizes the fees incurred by the Company during 2004 and
2005 for accountant and related services.

Audit Fees

- -------------------------------------------------------
                                    2005        2004
- -------------------------------------------------------
Malone & Bailey, PLLC                         $15,000
- -------------------------------------------------------
Lopez, Blevins, Bork & Assoc.      $17,875    $ 3,500
LLP
- -------------------------------------------------------

Audit-Related Fees

- -------------------------------------------------------
                                    2005        2004
- -------------------------------------------------------
Johnson & Sheldon                   $465       $575
- -------------------------------------------------------

Tax Fees

- -------------------------------------------------------
                                    2005       2004
- -------------------------------------------------------
Johnson & Sheldon                  $2,750     $2,100
- -------------------------------------------------------

All Other Fees

None.

                              STOCKHOLDER PROPOSALS
                        SUBMITTED PURSUANT TO Rule 14a-8

      Stockholders  may present  proposals for inclusion in the Company's  proxy
statement for the 2007 annual meeting of stockholders provided they are received
by the Company no later than February 10, 2007,  and are otherwise in compliance
with applicable Securities and Exchange Commission regulations.

                                       11


        STOCKHOLDER PROPOSALS SUBMITTED OUTSIDE THE PROCESS OF RULE 14a-8

      A shareholder  proposal for inclusion in the Company's Proxy Statement for
the 2007  Annual  Meeting  of  Stockholders,  which  is  submitted  outside  the
processes of Rule 14a-8,  will be considered  untimely if presented  after April
26, 2007.

                                     GENERAL

      So far as is now known,  there is no  business  other than that  described
above to be presented for action by the  stockholders at the meeting,  but it is
intended  that the proxies  will be voted upon any other  matters and  proposals
that may  legally  come  before  the  meeting  and any  adjournments  thereof in
accordance with the discretion of the persons named therein.

                              COST OF SOLICITATION

      The cost of  solicitation  of proxies will be borne by the Company.  It is
expected  that the  solicitations  will be made  primarily by mail,  but regular
employees  or  representatives  of the  Company  may  also  solicit  proxies  by
telephone or telegraph and in person, and arrange for brokerage houses and other
custodians, nominees and fiduciaries to send proxy material to the principals at
the expense of the Company.


                                             EDWARD L. MORRIS
                                             Secretary


                                       12


                        ANNUAL MEETING OF STOCKHOLDERS OF

                           AMARILLO BIOSCIENCES, INC.

                                  June 22, 2006

      Proof #1
      Revised


                           Please date, sign and mail
                             your proxy card in the
                            envelope provided as soon
                                  as possible.



     Please detach along perforated line and mail in the envelope provided.
[Arrow Pointing down]                                      [Arrow Pointing down]
- --------------------------------------------------------------------------------

                 THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR"
                      THE ELECTION OF DIRECTORS AND "FOR"
                           PROPOSAL 2 AND PROPOSAL 3.

         PLEASE SIGN, DATE AND RETURN PROMPTLY IN THE ENCLOSED ENVELOPE.
            PLEASE MARK YOUR VOTE IN BLUE OR BLACK INK AS SHOWN HERE |X|
- --------------------------------------------------------------------------------

                                                
   1. Election of                                  2. Authorize voting of your proxy      FOR  AGAINST ABSTAIN
      Directors:                                      upon such other business as may     |_|     |_|     |_|
                                                      properly come before the meeting.
                 NOMINEES:
  |_| FOR ALL    O Joseph M. Cummins
      NOMINEES   O Stephen Chen                    3. Authorize voting of your proxy for  FOR  AGAINST ABSTAIN
  |_| WITHHOLD   O James Page                         the purpose of adjourning the       |_|     |_|     |_|
      AUTHORITY  O Dennis Moore                       meeting for the purpose of
  |_| FOR ALL    O Thomas D'Alonzo                    soliciting additional votes.
      NOMINEES   O Thomas Ulie
  |_| FOR ALL                                      This proxy is solicited on behalf of the Board of Directors
      EXCEPT                                       of the Company. This proxy, when properly executed, will be
      (See                                         voted in accordance with the Instructions given above. If no
      instructions                                 instructions are given, this proxy will be voted "FOR"
      below)                                       election of the Directors and "FOR" proposal 2 and proposal
                                                   3.



INSTRUCTION:  To  withhold  authority  to vote for
              any individual nominee(s), mark "FOR
              ALL  EXCEPT"  and fill in the circle
              next to  each  nominee  you  wish to
              withhold, as shown here: O
- --------------------------------------------------

- --------------------------------------------------

To change the address on your account, please
check the box at right and indicate  your new   |_|
address in the address  space  above.  Please
note that changes to the  registered  name(s)
on the  account  may not be  substituted  via
this method.

- --------------------------------------------------


                                                      
Signature of Stockholder               Date:             Signature of Stockholder               Date:
                         -------------        ---------                           -------------        ---------

         Note:    Please  sign exactly as your name or names  appear on this Proxy.  When shares ate held  jointly,
                  each  holder  should  sign.   When  signing  as  executor,  administrator,  attorney,  trustee or
                  guardian,  please give full title as such.  If the  signer  is a  corporation, please  sign  full
                  corporate name by duly authorized officer, giving full title as such. If signer is a partnership,
                  please sign in partnership name by authorized person.




Proof #1
Revised


                                                               0


COMMON STOCK                                                               PROXY

                           AMARILLO BIOSCIENCES, INC.
                         Annual Meeting of Stockholders
                            To Be Held June 22, 2006
           This proxy is solicited on behalf of the Board of Directors

      Revoking any such prior  appointment,  the  undersigned,  a stockholder of
Amarillo  Biosciences,  Inc.,  hereby appoints Joseph M. Cummins,  Stephen Chen,
James Page,  and Dennis  Moore,  and each of them,  attorneys  and agents of the
undersigned,  with full power of substitution,  to vote all shares of the Common
Stock of the  undersigned in said Company at the Annual Meeting of  Stockholders
of said  Company to be held in the Days Inn Hotel East,  1701 E I-40,  Amarillo,
Texas 79102 on June 22, 2006 at 10:00 A.M. local time and subject to approval of
proposal  (3), at any  adjournments  thereof,  as fully and  effectually  as the
undersigned  could  do if  personally  present  and  voting,  hereby  approving,
ratifying and confirming all that said attorneys and agents or their substitutes
may lawfully do in place of the undersigned as indicated below.

      This  proxy  when  properly  executed  will be  voted as  directed.  If no
direction is indicated, this proxy will be voted for proposals (1), (2) and (3),
and will be voted in the  discretion  of the proxy  holders on other  matters to
properly come before the meeting.
                (Continued and to be signed on the reverse side)


                                                                           14475