EXHIBIT 32.1

CERTIFICATE OF THE PRINCIPAL EXECUTIVE OFFICER
OF DIOMED HOLDINGS, INC. (REGISTRANT)
PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

I, James A. Wylie, Jr., Chief Executive Officer of the Registrant, certify to
the best of my knowledge and belief pursuant to Section 906 of Sarbanes-Oxley
Act of 2002 (18 U.S.C. Section 1350) that:

(1) The Quarterly Report on Form 10-QSB for the period ended June 30, 2006,
which this statement accompanies, fully complies with the requirements of
section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Quarterly Report on Form 10-QSB fairly
presents, in all material respects, the financial condition and result of
operations of the Registrant.




The foregoing certification is being furnished solely pursuant to Section 906 of
the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of Section 1350, chapter
63 title 18, United States Code) and is not being filed as part of the Form
10-QSB or as a separate disclosure document.

Date:  August 11, 2006                /s/ JAMES A. WYLIE, JR.
                                      ---------------------------
                                      James A. Wylie, Jr.
                                      Chief Executive Officer
                                      (Principal Executive Officer)