EXHIBIT 10.1

               SECOND AMENDMENT TO OFFICE BUILDING LEASE AGREEMENT

                                    RECITALS

A.    HEALTHRENU MEDICAL, INC. ("Tenant") and DENMARK HOUSE INVESTMENT,  LTD., A
      TEXAS LIMITED PARTNERSHIP,  ("Landlord"),  entered into that certain Lease
      Agreement  effective  as of  the  30th  day of  June  2004  ("Lease")  and
      Amendment to Office Building Lease  Agreement  effective as of the 1st day
      of January 2006, in regard to the leasing of that certain space containing
      approximately  2,478 square feet, (the  "Premises") at the office building
      located at 12777 Jones Road, Houston, Texas 77070 (the "Project").

B.    Tenant  and  Landlord  desire to amend  certain  provisions  of the Lease,
      effective as of the 1st day of May 2006 (the "Effective Date");

NOW  THEREFORE,  for  good,  valuable  and  sufficient  consideration  received,
Landlord and Tenant hereby agree as follows:

                                    AGREEMENT

1.    On the  Effective  Date,  the Leased  Premises  shall be  decreased by 786
      non-contiguous   square  feet  of  Non  Rentable  Area  ("Decreased  Lease
      Premises"), as outlined on the attached Exhibit "A-2".

2.    On the Effective  Date, the Base Rent shall decrease to Two Thousand Three
      Hundred  Sixty-two and 50/100  Dollars  ($2,362.50)  per month through the
      31st day of January 2007. Effective the 1st day of February 2007, the Base
      Rent shall increase to Two Thousand Three Hundred  Ninety-seven and 00/100
      Dollars  ($2,397.00)  per month through the 31st day of February 2008, the
      Base Rent shall  increase to Two  Thousand  Four Hundred  Sixty-seven  and
      50/100 Dollars ($2,467.50) per month through the 31st day January 2009.

3.    Tenant shall  reimburse  Landlord for all costs  associated with the early
      termination  ("Termination Fee"). The total sum of the Termination Fee due
      from Tenant to Landlord is One Thousand  Eight  Hundred  Twelve and 57/100
      Dollars ($1,812.57).  This amount represents the unamortized leasing costs
      associated with the original leasing of the Decreased Leased Premises,  as
      defined in the First  Amendment to Office  Building Lease  Agreement and a
      termination  penalty charge.  These costs are Seven Hundred Thirty-one and
      84/100  Dollars  ($731.84)  and One  Thousand  Eighty and  75/100  Dollars
      ($1,080.75)  respectively.  Landlord agrees to deduct the Security Deposit
      on file from the  Termination  Fee,  reducing the  Termination  Fee due to
      Seven Hundred Thirty-one and 84/100 Dollars  ($731.84).  Tenant must remit
      payment of the  Termination  Fee to  Landlord  on or before the 5th day of
      May, 2006.

Except as  expressly  amended  herein,  the Lease  shall  control  the terms and
provisions  pertaining to the Lease and no modifications,  changes or amendments
in regard to the Lease other than expressly provided for herein are intended.


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                                                          EXHIBIT 10.1 CONTINUED

Dated as of the 13th day of April, 2006.

TENANT:                    HEALTHRENU MEDICAL, INC.

                           /S/ Robert W Prokos /S/
                           -------------------------
                           ROBERT W PROKOS, PRESIDENT



LANDLORD:                  DENMARK HOUSE INVESTMENT, LTD.
                           A TEXAS LIMITED PARTNERSHIP

                           By: Denmark House Management LLC.
                               A Texas limited liability company


                            /S/ Mark Winkleman /S/
                           ------------------------
                           Mark Winkleman, Manager


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                                                                     EXHIBIT A-2


                       [GRAPHIC OMITTED][GRAPHIC OMITTED]


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