SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

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                                    FORM 8-K

                                 CURRENT REPORT
                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                                November 14, 2007
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                                 Date of Report
                        (Date of earliest event reported)

                        MIDDLEBROOK PHARMACEUTICALS, INC.
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               (Exact Name of Registrant as Specified in Charter)

         Delaware                      000-50414               52-2208264
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(State or Other Jurisdiction    (Commission File Number)     (IRS Employer
     of Incorporation)                                     Identification No.)

            20425 Seneca Meadows Parkway, Germantown, Maryland 20876
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               (Address of Principal Executive Offices) (ZIP Code)

       Registrant's telephone number, including area code: (301) 944-6600
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          (Former Name or Former Address, if Changed Since Last Report)


Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

|_|   Written communications pursuant to Rule 425 under the Securities Act (17
      CFR 230.425)

|_|   Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
      240.14a-12)

|_|   Pre-commencement communications pursuant to Rule 14d-2(b) under the
      Exchange Act (17 CFR 240.14d-2(b))

|_|   Pre-commencement communications pursuant to Rule 13e-4(c) under the
      Exchange Act (17 CFR 240.13e-4(c))






Item 2.02.  Results of Operations and Financial Condition.

      On November 14, 2007, MiddleBrook Pharmaceuticals, Inc. issued a press
release announcing its financial results for the three months and nine months
ended September 30, 2007. A copy of the release is furnished as Exhibit 99.1 to
this Current Report on Form 8-K.

      The information in this Form 8-K and the Exhibit attached hereto shall not
be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act
of 1934, nor shall it be deemed incorporated by reference in any filing under
the Securities Act of 1933, except as shall be expressly set forth by specific
reference in such filing.

Item 9.01.  Financial Statements and Exhibits.

           (d)  Exhibits

           Exhibit      Description

           99.1         Press Release issued November 14, 2007


                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                         MIDDLEBROOK PHARMACEUTICALS, INC.


Date: November 14, 2007                  By:  /s/ Robert C. Low
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                                               Robert C. Low
                                               Vice President, Finance and
                                               Chief Financial Officer