UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                _________________

                                   FORM 12b-25

                                _________________

                           NOTIFICATION OF LATE FILING

(Check one):  |_| Form 10-K    |_| Form 20-F    |_| Form 11-K    |X| Form 10-Q
              |_| Form 10-D    |_| Form N-SAR   |_| Form N-CSR

              For Period Ended: June 30, 2012

              |_| Transition Report on Form 10-K
              |_| Transition Report on Form 20-F
              |_| Transition Report on Form 11-K
              |_| Transition Report on Form 10-Q
              |_| Transition Report on Form N-SAR

              For the Transition Period Ended:____________________

If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the notification relates:





                         PART I - REGISTRANT INFORMATION

Integrated Surgical Systems, Inc.
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Full Name of Registrant


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Former Name if Applicable

401 Wilshire Blvd., Ste. 1020
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Address of Principal Executive Office (Street and Number)

Santa Monica, CA 90401
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City, State and Zip Code


                        PART II - RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)


     (a)  The reason described in reasonable detail in Part III of this form
          could not be eliminated without unreasonable effort or expense;

     (b)  The subject annual report, semi-annual report, transition report on
          Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion
|X|       thereof, will be filed on or before the fifteenth calendar day
          following the prescribed due date; or the subject quarterly report or
          transition report on Form 10-Q or subject distribution report on Form
          10-D,or portion thereof, will be filed on or before the fifth calendar
          day following the prescribed due date; and

     (c)  The accountant's statement or other exhibit required by Rule 12b-25(c)
          has been attached if applicable.


                              PART III - NARRATIVE

State below in reasonable detail the reasons why Forms 10-K, 20-F, 11-K, 10-Q,
10-D, N-SAR, N-CSR, or the transition report or portion thereof, could not be
filed within the prescribed time period. (Attach extra Sheets if Needed)

Last minute legal review and changes to 10-Q prevented auditor from signing off
on filing until 8/15/12.


                           PART IV - OTHER INFORMATION

(1)  Name and telephone number of person to contact in regard to this
     notification


              Gary Schuman                    310               526-5006
     ---------------------------------  -----------------  ---------------------
                 (Name)                   (Area Code)       (Telephone Number)

(2)  Have all other periodic reports required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months or for such shorter period that the
     registrant was required to file such report(s) been filed? If answer is no,
     identify report(s).

                                                            Yes  |X|     NO  |_|

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(3)  Is it anticipated that any significant change in results of operations from
     the corresponding period for the last fiscal year will be reflected by the
     earnings statements to be included in the subject report or portion
     thereof?

                                                            Yes  |_|     NO  |X|

     If so, attach an explanation of the anticipated change, both narratively
     and quantitatively, and, if appropriate, state the reasons why a reasonable
     estimate of the results cannot be made.


                       Integrated Surgical Systems, Inc.
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                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Date: 8/15/2012                      By: /s/ Gary Schuman
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                                         CFO