Filed Pursuant to Rule 424(b)(3)
                                                     Registration No. 333-126687


Prospectus Supplement No. 2
to Prospectus dated August 11, 2005


                              PHARMAFRONTIERS CORP.

                                36,148,266 SHARES

     We are further  supplementing  the  prospectus  dated August 11,  2005,  to
provide information contained in our:

          o    Current Report on Form 8-K filed September 1, 2005;
          o    Current Report on Form 8-K filed on October 19, 2005;
          o    Current Report on Form 8-K filed on October 26, 2005;
          o    Proxy  Statement,  dated  October 14,  2005,  pursuant to Section
               14(a) of the Securities Exchange Act of 1934; and
          o    Current Report on Form 8-K filed on November 1, 2005.

     This  Prospectus  Supplement  is  not  complete  without,  and  may  not be
delivered or utilized except in connection with, the Prospectus dated August 11,
2005,  with  respect to the  resale of the  36,148,266  shares of common  stock,
including any amendments or supplements thereto.

     INVESTING  IN OUR COMMON STOCK  INVOLVES A HIGH DEGREE OF RISK.  YOU SHOULD
READ CAREFULLY THIS ENTIRE  PROSPECTUS,  INCLUDING THE SECTION  CAPTIONED  "RISK
FACTORS" BEGINNING ON PAGE 3, BEFORE MAKING A DECISION TO PURCHASE OUR STOCK.

     NEITHER THE  SECURITIES AND EXCHANGE  COMMISSION  NOR ANY STATE  SECURITIES
COMMISSION HAS APPROVED OR  DISAPPROVED  OF THESE  SECURITIES OR PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


                 The date of this Supplement is November 2, 2005







                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                ----------------

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

        Date of report (Date of earliest event reported): August 29, 2005

                                ----------------

                              PharmaFrontiers Corp.
                              ---------------------
             (Exact Name of Registrant as Specified in Its Charter)


                                      Texas
                                      -----
                 (State or Other Jurisdiction of Incorporation)

             000-25513                                   76-0333165
             ---------                                   ----------
      (Commission File Number)              (I.R.S. Employer Identification No.)

   2408 Timberloch Place, Suite B-7
        The Woodlands, Texas                               77380
        --------------------                               -----
(Address of Principal Executive Offices)                 (Zip Code)

       Registrant's telephone number, including area code: (281) 272-9331

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17
    CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
    CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the
    Exchange Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the
    Exchange Act (17 CFR 240.13e-4(c))




Item 5.02. Departure of Directors or Principal Officers; Election of Directors;
           Appointment of Principal Officers.

     On August 29, 2005, Terry Wesner was appointed to the Board of Directors.
Mr. Wesner will serve on the Board's Nominating Committee.

     Mr. Wesner has not been involved with a related transaction or relationship
as defined by Item 404(a) of Regulation S-B between the Company and him.
Additionally, there is no arrangement or understanding between Mr. Wesner and
any other person pursuant to which Mr. Wesner was selected as a director.




                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                     PHARMAFRONTIERS CORP.


                                                     By: /s/ David B. McWilliams
                                                         -----------------------
                                                         David B. McWilliams,
                                                         Chief Executive Officer


DATE: September 1, 2005






                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                               ------------------

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

       Date of report (Date of earliest event reported): October 17, 2005

                              --------------------

                              PharmaFrontiers Corp.
             (Exact Name of Registrant as Specified in Its Charter)
             ------------------------------------------------------


                                      Texas
                                      -----
                 (State or Other Jurisdiction of Incorporation)

           000-25513                                     76-0333165
           ---------                                     ----------
   (Commission File Number)                 (I.R.S. Employer Identification No.)

           2635 Crescent Ridge Drive
             The Woodlands, Texas                                77381
             --------------------                                -----
   (Address of Principal Executive Offices)                    (Zip Code)

       Registrant's telephone number, including area code: (281) 272-9331

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act
    (17 CFR 230.425)

[ ] Soliciting material pursuant to Rule 14a-12 under the Exchange Act
    (17 CFR 240.14a-12)

[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
    Act (17 CFR 240.14d-2(b))

[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
    Act (17 CFR 240.13e-4(c))





Item  5.02.       Departure of Directors or Principal Officers; Election of
Directors; Appointment of Principal Officers.

         On October 17, 2005, Brooks Boveroux was elected to the Board of
Directors. Mr. Boveroux will serve on the Board's Audit Committee. Mr. Boveroux
entered into a standard director's agreement whereby he received ten year
options to purchase 52,500 shares of Company common stock at an exercise price
per share of $1.15 for agreeing to serve on the Board and the Audit Committee.
There is no other arrangement or understanding between Mr. Boveroux and any
other person pursuant to which Mr. Boveroux was selected as a director. Mr.
Boveroux has not been involved with a related transaction or relationship as
defined by Item 404(a) of Regulation S-B between the Company and him.



Item 9.01         Financial Statements and Exhibits

(c)        Exhibit 99.1

The following exhibits are to be filed as part of this 8-K:


Exhibit No.          Description

99.1                 Press release issued October 18, 2005


                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                              PHARMAFRONTIERS CORP.


                              By: /s/ David B. McWilliams
                              ---------------------------
                              David B. McWilliams, Chief Executive Officer



DATE:  October 19, 2005






                                  EXHIBIT LIST

Exhibit No.          Description

99.1                 Press release issued October 18, 2005











                                  End of report


                                                                    Exhibit 99.1

PharmaFrontiers Corp. Names Brooks Boveroux to Board of Directors

    THE WOODLANDS, Texas--(BUSINESS WIRE)--Oct. 18,
2005--PharmaFrontiers Corp. (OTCBB:PFTR), a company involved in the
development and commercialization of cell therapies, announced that
Brooks Boveroux has been elected to serve as a member of its board of
directors. He will also join PharmaFrontiers' audit committee. Mr.
Boveroux, age 62, has held the post of vice president of finance for
several prominent biotechnology companies including Biogen, Inc.,
ImClone Systems, Inc. and The Liposome Company, Inc. His career spans
over two decades of senior level financial positions of both public
and private companies in the health care industry and his last
position was chief financial officer of Imcor Pharmaceutical Co., a
specialty pharmaceutical company, from which he retired in 2004.
    David McWilliams, chief executive officer of PharmaFrontiers
Corp., commented, "We are pleased to have Mr. Boveroux join our board
of directors. His broad experience in finance and background in health
care and pharmaceutical organizations will add significant value and
insight to the board."
    Mr. Boveroux received a Bachelor of Arts in English Literature
from Hamilton College and a Masters of Business Administration in
Finance from the Wharton Graduate Division, University of
Pennsylvania.

    About PharmaFrontiers Corp.

    PharmaFrontiers' strategy is to develop and commercialize cell
therapies to treat several major disease areas such as cardiac and
pancreatic conditions and Multiple Sclerosis. PharmaFrontiers owns
patented and proprietary individualized cell therapies that are in FDA
Phase I/II human dose ranging clinical trials to evaluate their safety
and effectiveness in treating MS. The company also holds the exclusive
worldwide license from the University of Chicago, through its prime
contractor relationship with Argonne National Laboratory, for patents
relating to the use of adult pluripotent stem cells derived from
patients' own circulating blood.

    Safe Harbor Statement

    This press release contains "forward-looking statements,"
including statements about PharmaFrontiers' growth and future
operating results, discovery and development of products, strategic
alliances and intellectual property, as well as other matters that are
not historical facts or information. These forward-looking statements
are based on management's current assumptions and expectations and
involve risks, uncertainties and other important factors, specifically
including those relating to PharmaFrontiers' ability to obtain
additional funding, develop its stem cell technologies, achieve its
operational objectives and obtain patent protection for its
discoveries that may cause PharmaFrontiers' actual results to be
materially different from any future results expressed or implied by
such forward-looking statements. PharmaFrontiers undertakes no
obligation to update or revise any such forward-looking statements,
whether as a result of new information, future events or otherwise.

    CONTACT: PharmaFrontiers Corp.
             C. William Rouse, 281-775-0608
             brouse@pharmafrontierscorp.com
             or
             Investor Relations Contacts:
             Lippert/Heilshorn & Associates
             Kim Sutton Golodetz, 212-838-3777
             kgolodetz@lhai.com
             Bruce Voss, 310-691-7100
             bvoss@lhai.com
             or
             Media Relations Contact:
             Lippert/Heilshorn & Associates
             Mark Stuart, 310-691-7100
             mstuart@lhai.com



                                  UNITED STATES
                         SECURITIES EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of

                       The Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): October 20, 2005

                              PHARMAFRONTIERS CORP.
- -------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)


         Texas                      000-25513                 760333165
- -----------------------       -----------------------     -------------------
(State of organization)       (Commission File Number)     (IRS Employer
                                                          Identification No.)

2635 N. Crescent Ridge Drive
The Woodlands, Texas                                        77381
- -------------------------------------------------------------------------------
(Address of principal executive offices)                 (Zip Code)


Registrant's Telephone Number, including area code: (281) 272-9331

Former name or former address, if changed since last report: Not Applicable

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

|_|  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a- 12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))







Item  5.02.       Departure of Directors or Principal Officers;
                  Election of Directors; Appointment of
                  Principal Officers.

         On October 19, 2005, Robert Gow, sent a letter to the chief executive
officer of the company requesting that he address certain concerns within five
days. Prior to the company's ability to respond, on October 20, 2005, Mr. Gow
submitted his resignation as chairman and member of the board. The board of
directors has formed a special committee comprised of independent directors to
address Mr. Gow's letter, and the special committee has commenced its review of
the circumstances surrounding the resignation and recommended to the board for
approval certain measures it believes address corporate governance concerns
raised by Mr. Gow. The special committee will continue its review and make such
further recommendations as it deems necessary and appropriate. Mr. Gow's letters
are filed herewith as Exhibits 17.1 and 17.2 and are incorporated herein by
reference. Mr. Gow had served on the board since June 2004, as well as the
nominating, compensation and audit committees.

         On October 25, 2005, the board of directors unanimously elected Brooks
Boveroux, a director and member of the audit committee, as interim chairman,
succeeding Mr. Gow.


Item  9.01.       Financial Statements and Exhibit

         (c)      Exhibits


The following exhibits are to be filed as part of this 8-K:


     EXHIBIT NO.                  IDENTIFICATION OF EXHIBIT
     ----------                   -------------------------
       17.1                  Letter expressing concerns of director.
       17.2                  Letter of resignation.
       99.1                  Press Release dated October 26, 2005.




                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                              PHARMAFRONTIERS CORP.

                              By: /s/ David B. McWilliams
                              ---------------------------
                              David B. McWilliams,
                              Chief Executive Officer

DATE:  October 26, 2005

                                  EXHIBIT INDEX


Exhibit No.                   Description
- -------------                 ----------------------
       17.1                  Letter expressing concerns of director.
       17.2                  Letter of resignation.
       99.1                  Press Release dated October 26, 2005.



                                                                    Exhibit 17.1


                                  ROBERT H. GOW
                                5 Woods Edge Lane
                                Houston, TX 77024
                                 (713) 278-7344
                              (713) 278-7355 (Fax)
                            Yucabambu@aol.com (Email)



October 19, 2005


Mr. David McWilliams
Chief Executive Officer
PharmaFrontiers Corporation
2635 North Crescent Ridge Drive
The Woodlands, TX  77381

Dear Dave:

As the chairman and a member of the board of directors of PharmaFrontiers, I
have become deeply concerned with the actions of management and certain members
of the board of directors who appear to be operating under the influence of
management without exercising independent judgment.

This concern arises as the result of my understanding and firm belief (as often
emphasized to my business students at Rice) that both members of a corporation's
board of directors and its management owe the duties of a "Fiduciary" to such
corporation's shareholders. It is my further understanding that this duty, as a
Fiduciary, imposes a number of obligations including the "Duty of Due Care" the
"Duty of Loyalty" and the "Duty of Good Faith."

The Duty of Due Care requires the gathering of all material information
reasonably available before making a decision and the duty to consider all
reasonable alternatives.

  The Duty of Loyalty includes the duty to promote the best interests of the
  corporation and its stockholders and refrain from conduct that would deprive
  them of benefits. This duty is violated where: (1) a director or officer
  promotes a transaction in which he or she possesses an economic interest; (2)
  a director or officer fails to disclose to other members when he is aware that
  a transaction involves fraud, misrepresentation, self dealing or conflicts. A
  corollary to this duty of Loyalty is the requirement that a director's
  decision must be independent. This duty is violated if the director making the
  decision has a personal interest in the decision, or has a relationship with
  someone who possesses a financial interest in the transaction and will benefit
  at the expense of the corporation.

The Duty of "Good Faith" is violated when the board or management acts with
disregard to the best interests of the shareholders, whether out of carelessness
or through manipulation by its members or management.



Mr. David McWilliams October 19, 2005
Page 2



My concerns arise from the following observations:

1.       I believe the Company has not pursued a course of financing designed to
         maximize the benefit of shareholders.

2.       I believe the Company's management has not actively pursued a course of
         action designed to increase or even preserve the value of the Company's
         stock.

3.       I believe the Company's management has failed to timely terminate
         investment bankers that were not acting in good faith and failed to
         perform as represented;

4.       I believe the Company's management has not, in some cases, provided
         complete and accurate information to all directors, in an attempt to
         stall decision making or manipulate the decision of the board of
         directors or in some cases even mislead them;

5.       I believe management has circumvented the determinations to be made by
         independent committees established under Sarbanes Oxley requirements,
         in order to achieve personal objectives and influence decision making
         within the Company.

These and other things worry me. I have devoted a great deal of time and effort
to PharmaFrontiers trying to change them. I feel frustrated at not having been
able to do so. I am concerned that some people may feel I approve of our
direction and condone this behavior because I am on the Board. I do not.

Unless something happens in the next five days to make me believe things will be
different, I must reconsider my position as a board member. I do not flatter
myself by expecting this to cause great consternation. However, I hope that, for
the sake of the Company's shareholders, you will give it due consideration.

Sincerely,


Robert H. Gow


cc:      Paul Frison
         Brian Rodriguez
         Tony Kamin
         Terry Wesner
         Brooks Boveroux
         Tom Pritchard



                                                                    Exhibit 17.2


From: Robert H. Gow
Sent: Thursday, October 20, 2005 6:39 PM
To: David McWilliams

Cc: Paul Frison, Brian Rodriguez, Tony Kamin, Terry Wesner, Brooks Boveroux,
    Thomas Pritchard

Subject:

Dave,

I am happy to talk with any member of the Board at any time; However, please
consider this communication my formal resignation as Chairman and as a member of
the Board of Directors of PharmaFrontiers, effective at this time.

Bob Gow



                                                                    Exhibit 99.1

             PharmaFrontiers Corp. Elects Interim Chairman

    THE WOODLANDS, Texas--(BUSINESS WIRE)--Oct. 26,
2005--PharmaFrontiers Corp. (OTCBB:PFTR), a company involved in the
development and commercialization of cell therapies, announced today
that Brooks Boveroux, a director of the Company, has been unanimously
elected interim chairman of the board, effective immediately. Mr.
Boveroux, age 62, is replacing Robert H. Gow, who has resigned from
both the board of directors and his position as chairman.
    "I am pleased to be taking on the role as interim chairman of
PharmaFrontiers at this important time," said Mr. Boveroux. "My fellow
Board members and I thank Bob for his contributions to the Company and
wish him well in his future endeavors. This is an exciting time as we
prepare to implement our upcoming Phase IIb trials for Tovaxin(TM) in
Multiple Sclerosis. We are encouraged about the power of our
technology to treat this devastating disease."
    Mr. Boveroux's career has spanned over two decades of senior level
financial positions with public and private companies both in the
research stage and those marketing approved products in the health
care industry. His last position was chief financial officer of Imcor
Pharmaceutical Co., a specialty pharmaceutical company, from which he
retired in 2004. Mr. Boveroux has held the post of vice president of
finance for several prominent biotechnology companies including
Biogen, Inc., ImClone Systems, Inc. and The Liposome Company, Inc.
    David McWilliams, chief executive officer of PharmaFrontiers
Corp., commented, "Mr. Boveroux's leadership and experience in the
health care industry will be a key contributor as PharmaFrontiers
advances its clinical program. I believe this is the ideal time in the
Company's development to appoint a chairman who possesses a wealth of
biopharmaceutical and financial skills and experience."

    About PharmaFrontiers Corp.

    PharmaFrontiers' strategy is to develop and commercialize cell
therapies to treat several major disease areas such as cardiac and
pancreatic conditions and Multiple Sclerosis. PharmaFrontiers owns
patented and proprietary individualized cell therapies that are in FDA
Phase I/II human dose ranging clinical trials to evaluate their safety
and effectiveness in treating MS. The company also holds the exclusive
worldwide license from the University of Chicago, through its prime
contractor relationship with Argonne National Laboratory, for patents
relating to the use of adult pluripotent stem cells derived from
patients' own circulating blood.

    Safe Harbor Statement

    This press release contains "forward-looking statements,"
including statements about PharmaFrontiers' growth and future
operating results, discovery and development of products, strategic
alliances and intellectual property, as well as other matters that are
not historical facts or information. These forward-looking statements
are based on management's current assumptions and expectations and
involve risks, uncertainties and other important factors, specifically
including those relating to PharmaFrontiers' ability to obtain
additional funding, develop its stem cell technologies, achieve its
operational objectives, and obtain patent protection for its
discoveries, that may cause PharmaFrontiers' actual results to be
materially different from any future results expressed or implied by
such forward-looking statements. PharmaFrontiers undertakes no
obligation to update or revise any such forward-looking statements,
whether as a result of new information, future events or otherwise.



    CONTACT: PharmaFrontiers Corp., The Woodlands
             C. William Rouse, 281-775-0608
             brouse@pharmafrontierscorp.com
             or
             Lippert/Heilshorn & Associates
             Investor Relations Contacts:
             Kim Sutton Golodetz, 212-838-3777
             kgolodetz@lhai.com
             or
             Bruce Voss, 310-691-7100
             bvoss@lhai.com
             or
             Lippert/Heilshorn & Associates
             Media Relations Contact:
             Mark Stuart, 310-691-7100
             mstuart@lhai.com



                                  SCHEDULE 14A
                                 (RULE 14A-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION

           PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                              EXCHANGE ACT OF 1934


Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement     [ ] Confidential, for Use of the Commission
[X]  Definitive Proxy Statement          Only (as permitted by Rule 14a-6(e)(2))
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12


                              PHARMAFRONTIERS CORP.
                              ---------------------
                (Name of Registrant as Specified in Its Charter)

               Payment of Filing Fee (Check the appropriate box):

                              [X] No fee required.

  [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1)  Title of each class of securities to which transaction applies:

(2)  Aggregate number of securities to which transaction applies:

(3)  Per unit price or other underlying value of transaction computed pursuant
     to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee is
     calculated and state how it was determined):

(4)  Proposed maximum aggregate value of transaction:

(5)  Total fee paid:

               [ ] Fee paid previously with preliminary materials.

          [ ] Check box if any part of the fee is offset as provided by
         Exchange Act Rule 0-11(a)(2) and identify the filing for which
          the offsetting fee was paid previously. Identify the previous
        filing by registration statement number, or the Form or Schedule
                           and the date of its filing.

(1) Amount Previously Paid:

(2) Form, Schedule or Registration Statement No.:

(3) Filing Party:

(4) Date Filed:





                              PHARMAFRONTIERS CORP.
                          2635 N. Crescent Ridge Drive
                             The Woodlands, TX 77381


October 14, 2005


To Our Shareholders:

     You are cordially  invited to attend the Special Meeting of Shareholders of
PharmaFrontiers  Corp to be held at 2635 N. Crescent Ridge Drive, The Woodlands,
Texas 77381, at 3:00 p.m., Central Time, Friday,  November 11, 2005. Information
about the Special Meeting,  including the matter on which shareholders will act,
may be found in the notice of special meeting and proxy  statement  accompanying
this letter.  We look forward to greeting in person as many of our  shareholders
as possible.

     It is important that your shares be  represented  and voted at the meeting.
Whether or not you plan to attend the Special Meeting,  please  complete,  sign,
date,  and promptly  return the  accompanying  proxy in the  enclosed  envelope.
Alternatively,  you may send your  completed  and signed proxy via  facsimile to
(281) 872-8585. Returning the proxy does NOT deprive you of your right to attend
the Special  Meeting.  If you decide to attend the  Special  Meeting and wish to
change your proxy vote, you may do so  automatically  by voting in person at the
meeting.  Please  note,  however,  that if your  shares  are held of record by a
broker,  bank or other  nominee and you wish to attend and vote in person at the
meeting, you must obtain from the record holder a proxy issued in your name.


Sincerely yours,

/s/DAVID B. MCWILLIAMS

David B. McWilliams
President, CEO





                              PHARMAFRONTIERS CORP.
                          2635 N. Crescent Ridge Drive
                             The Woodlands, TX 77381
              -----------------------------------------------------

                    NOTICE OF SPECIAL MEETING OF SHAREHOLDERS

              -----------------------------------------------------

     The Special Meeting of Shareholders of  PharmaFrontiers  Corp. will be held
at 2635 N.  Crescent  Ridge Drive,  The  Woodlands,  Texas 77381,  at 3:00 p.m.,
Central Time, Friday, November 11, 2005, for the following purpose:

     Approval to amend our Articles of  Incorporation to increase the authorized
     shares of common  stock  that we have  authority  to issue  from 50 million
     shares to 100 million shares.

     This  business  item  is  described  more  fully  in  the  Proxy  Statement
accompanying  this Notice.  Only  shareholders who owned our common stock at the
close  of  business  on  October  5,  2005,  can  vote  at this  meeting  or any
adjournments  that may take place.  All  shareholders  are cordially  invited to
attend the  meeting in person.  However,  to assure your  representation  at the
meeting,  you are urged to mark,  sign and return the enclosed proxy as promptly
as possible in the postage-prepaid envelope for that purpose. Alternatively, you
may send your  completed and signed proxy via  facsimile to (281)  872-8585 Your
stock will be voted in  accordance  with the  instructions  you have given.  Any
shareholder  attending  the  meeting  may vote in  person  even if he or she has
previously returned a proxy. Please note, however,  that if your shares are held
of record by a broker,  bank or other nominee and you wish to attend and vote in
person at the meeting,  you must obtain from the record holder a proxy issued in
your name.


By Order of the Board of Directors,

/s/ROBERT H. GOW

Robert H. Gow
Chairman

Dated: October 14, 2005



PLEASE  DATE  AND  SIGN  THE  ENCLOSED  PROXY  AND  RETURN  IT AT YOUR  EARLIEST
CONVENIENCE  IN THE  ENCLOSED  ENVELOPE SO THAT YOUR SHARES WILL BE VOTED IF YOU
ARE NOT ABLE TO ATTEND THE SPECIAL MEETING.





                              PHARMAFRONTIERS CORP.

                                 PROXY STATEMENT


                         SPECIAL MEETING OF SHAREHOLDERS

                         TO BE HELD ON NOVEMBER 11, 2005
                 INFORMATION CONCERNING SOLICITATION AND VOTING


General

     The enclosed proxy is solicited on behalf of the Company's Board for use at
the Special Meeting of Shareholders to be held on Friday,  November 11, 2005, at
3:00 p.m.,  Central  Time (the  "Special  Meeting"),  or at any  adjournment  or
postponement of this meeting,  for the purpose set forth in this Proxy Statement
and in the accompanying  Notice of Special Meeting of Shareholders.  The Special
Meeting will be held at 2635 N.  Crescent  Ridge  Drive,  The  Woodlands,  Texas
77381.  We intend to mail this Proxy  Statement and  accompanying  proxy card to
shareholders   on  or  about  October  14,  2005.  The  Board  of  Directors  of
PharmaFrontiers  Corp., a Texas  corporation,  prepared this proxy statement for
the purpose of soliciting proxies for our Special Meeting of Shareholders.  When
you  see the  term  "we,"  "our,"  the  "Company"  or  "Pharma,"  it  refers  to
PharmaFrontiers Corp., and its subsidiaries.

Revocability of Proxies

     Any proxy given pursuant to this  solicitation may be revoked by the person
giving it at any time before its use by delivering  to the Company's  Secretary,
at the address of the Company's executive offices noted above, written notice of
revocation  or a duly  executed  proxy  bearing a later date or by attending the
Special  Meeting and voting in person.  Attendance  at the Special  Meeting will
not, by itself,  revoke a proxy. Please note,  however,  that if your shares are
held of record by a broker,  bank or other  nominee  and you wish to attend  and
vote in person at the Special Meeting,  you must obtain from the record holder a
proxy issued in your name.

Quorum; Abstentions and Broker Non-Votes

     Our  common  stock is the only  type of  security  entitled  to vote at the
Special Meeting. Only shareholders of record at the close of business on October
5, 2005 (the  "Record  Date")  will be  entitled to notice of and to vote at the
Special  Meeting.  At the close of  business  on the  Record  Date,  there  were
20,609,545  shares of common stock outstanding and entitled to vote. Each holder
of record of shares of common  stock on that date will be  entitled  to one vote
for each share held on all  matters  to be voted  upon at the  Special  Meeting.
Shares of common stock may not be voted cumulatively.

     Proxies  properly  executed,  duly  returned to the Company and not revoked
will  be  voted  in  accordance   with  the   specifications   made.   Where  no
specifications  are given, such proxies will be voted "FOR" the amendment to the
Articles of  Incorporation  to increase the aggregate number of shares of common
stock authorized for issuance from 50 million to 100 million.

     The required  quorum for the transaction of business at the Special Meeting
is a majority of the issued and outstanding shares of the Company's common stock
entitled  to  vote  at  the  Special  Meeting,  whether  present  in  person  or
represented by proxy.  Shares of common stock  represented by a properly  signed
and  returned  proxy  will be treated as  present  at the  Special  Meeting  for
purposes of  determining a quorum,  regardless of whether the proxy is marked as
casting a vote or abstaining.  Shares of stock represented by "broker non-votes"
(i.e.,  shares of stock held in record  name by brokers or  nominees as to which
(i)  instructions  have not been received from the beneficial  owners or persons
entitled to vote; (ii) the broker or nominee does not have discretionary  voting
power under  applicable  rules or the  instrument  under which it serves in such
capacity;  or (iii) the  record  holder has  indicated  on the proxy card or has
executed  a proxy  and  otherwise  notified  the  Company  that it does not have
authority  to vote such  shares on that  matter)  will be treated as present for
purposes of determining a quorum.


                                       1




Voting

     An  increase  in the  authorized  number of common  shares that we have the
authority  to issue from 50 million  shares to 100 million  shares  requires the
affirmative  vote of holders of a majority of the shares of common  stock issued
and  outstanding  and entitled to vote at the Special  Meeting.  Abstentions and
broker  non-votes  will not be counted as having been voted on the  proposal and
will have not effect on the proposal.

Solicitation

     The cost of soliciting proxies will be borne by the Company. In addition to
soliciting  shareholders by mail and through its regular employees,  the Company
will request that banks and brokers and other  persons  representing  beneficial
owners of the shares forward the proxy solicitation  material to such beneficial
owners  and the  Company  may  reimburse  these  parties  for  their  reasonable
out-of-pocket costs. The Company may use the services of its officers, directors
and  others  to  solicit  proxies,  personally  or by  telephone,  facsimile  or
electronic mail, without additional compensation.

Shareholder Proposals

     Proposals  of  shareholders  that are  intended to be presented at our 2006
Annual  Meeting of  Shareholders  in the proxy  materials  for such meeting must
comply  with the  requirements  of SEC Rule  14a-8 and must be  received  by our
Secretary no later than  January 16, 2006,  in order to be included in the Proxy
Statement  and  proxy   materials   relating  to  our  2006  Annual  Meeting  of
Shareholders.  Moreover,  with  respect to any  proposal  by a  shareholder  not
seeking to have the proposal included in the proxy statement but seeking to have
the  proposal  considered  at our next annual  meeting,  such  shareholder  must
provide  written  notice of such  proposal  to our  Secretary  at our  principal
executive  offices by March 16,  2006.  With  respect  to a  proposal  not to be
included in the proxy  statement,  in the event notice is not timely given,  and
the proposal is permitted at the annual  meeting,  the persons who are appointed
as proxies may exercise  their  discretionary  voting  authority with respect to
such proposals,  if the proposal is considered at our next annual meeting,  even
if the  shareholders  have  not  been  advised  of the  proposal.  In  addition,
shareholders  must comply in all respects with the rules and  regulations of the
Securities   and  Exchange   Commission   then  in  effect  and  the  procedural
requirements of our bylaws.

Dissenter's Rights

     Neither Texas law nor our articles of  incorporation  or bylaws provide our
shareholders  with  dissenters'  rights in connection  with the amendment of the
Articles of Incorporation.


          PROPOSAL - APPROVAL OF AN AMENDMENT TO INCREASE THE NUMBER OF
                            AUTHORIZED COMMON SHARES

     Our Board of  Directors  proposes  that you  approve  an  amendment  of our
Articles of Incorporation to increase the number of authorized common stock from
the current 50 million shares to a new total of 100 million shares.  The current
issued and outstanding  number of shares of common stock is 20,609,545 and there
are derivative  securities  outstanding  that provide the right to acquire up to
25,193,262  shares of common stock. We have no current plans to issue any shares
of common stock.

Description of our Common Stock

     Each  share of  common  stock is  entitled  to one vote per  share  for the
election  of  directors  and  on  all  other  matters  submitted  to a  vote  of
stockholders.  There are no cumulative voting rights to subscribe for additional
shares, and the common stock is not subject to conversion or redemption.  In the
event of  liquidation,  the holder of common  stock  will  share  equally in the
balance of corporate assets  available for distribution to them.  Subject to the
rights of holders of any other securities  subsequently  issued,  holders of the
common stock are entitled to receive dividends when and as declared by our Board
of Directors  out of funds  legally  available.  We have not paid any  dividends
since  inception and have no intention to pay any  dividends in the  foreseeable
future.  Any future dividends would be subject to the discretion of the Board of
Directors  and would depend on, among other  things,  our future  earnings,  the
operating  and  financial  condition,  our  capital  requirements,  and  general
business conditions.


                                       2




Reason for the Increase

     We believe that the increase  will provide  better  flexibility  in raising
additional capital in the future. Among other things, the increase in the number
of shares of common stock will make available shares for future  activities that
are  consistent  with  our  growth  strategy,   including,  without  limitation,
completing  financings,  establishing  strategic  relationships,   acquiring  or
investing  in  complementary   businesses  or  products,  and  providing  equity
incentives to employees.

     Current holders of common stock have no preemptive rights, which means that
current  stockholder  do not have prior rights to purchase a new issue of common
stock in order to maintain their current  ownership.  The issuance of additional
shares of common  stock will  decrease  the  proportionate  equity  ownership of
current  shareholders  and,  depending  upon the price paid for such  additional
shares, could result in dilution to current stockholders.

     The  proposed  amendment  could,  under  certain  circumstances,   have  an
anti-takeover  effect,  although this is not the  intention of the Company.  For
example,  the substantial increase in the number of authorized shares could help
management frustrate efforts of shareholders seeking to remove management, could
have the effect of limiting  shareholder  participation in transactions  such as
merger or tender offers, regardless of whether those transactions are favored by
incumbent management.  In addition, the board of directors will have the ability
to issue shares privately in transactions that could frustrate proposed mergers,
tender  offers,  or  other  transactions,  even  if  those  transactions  are at
substantial   market  premiums  and  are  favored  by  majority  of  independent
shareholders.  Such an issuance of shares of common  stock  would  increase  the
number of outstanding shares,  thereby possibly diluting the interest of a party
attempting to obtain control of the Company.

Effect of Increase

     Upon the filing of the  amendment  of our articles of  incorporation,  as a
general matter, approval from the stockholders will not be required to issue any
newly-authorized shares, except as otherwise required by law or applicable rules
of any market upon which our common stock may trade.

Form of Amendment of Article IV of the Articles of Incorporation.

     Attached  hereto as  Exhibit  "A" is a form of  amended  Article  IV to the
Articles of  Incorporation  the only change from the existing  Article IV is the
change from  authorized  capital  stock of 60 million  shares to the  authorized
capital stock of 110 million shares,  consisting, in part, of 100 million shares
of  authorized  common stock instead of 50 million  shares of authorized  common
stock.

THE BOARD OF DIRECTORS  RECOMMENDS THAT YOU VOTE "FOR" APPROVAL OF THE AMENDMENT
TO  INCREASE  THE NUMBER OF  AUTHORIZED  SHARES OF COMMON  STOCK FROM 50 MILLION
SHARES TO 100 MILLION SHARES.

                 SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS

     The following table sets forth, as of October 5, 2005, certain  information
with respect to shares beneficially owned by: (a) each person who is known by us
to be the beneficial  owner of more than 5% of our outstanding  shares of common
stock; (b) each of our directors; (c) the named executive officers as defined in
Item  402 of  Regulation  S-B;  and  (c) all  current  directors  and  executive
officers, as a group.

     Beneficial  ownership has been  determined  in  accordance  with Rule 13d-3
under the Securities  Exchange Act of 1934  ("Exchange  Act").  Under this rule,
certain  shares may be deemed to be  beneficially  owned by more than one person
(if, for example, persons share the power to vote or the power to dispose of the
shares). In addition,  shares are deemed to be beneficially owned by a person if
the person has the right to acquire  shares (for  example,  upon  exercise of an
option or warrant)  within sixty days of the date as of which the information is
provided.  In computing the  percentage  ownership of any person,  the amount of
shares is deemed to  include  the  amount of shares  beneficially  owned by such
person by reason of such  acquisition  rights.  As a result,  the  percentage of
outstanding  shares  of any  person  as shown in the  following  table  does not
necessarily reflect the person's actual voting power at any particular date.


                                       3




     To our  knowledge,  except as indicated in the  footnotes to this table and
pursuant to applicable  community  property laws, the persons named in the table
have sole voting and investment power with respect to all shares of common stock
shown as beneficially owned by them.

                                             ------------------- ---------------
                                              Number of Shares    Percentage of
  Name and Address of Beneficial Owner           Owned (1)            Class
- ------------------------------------------   ------------------- ---------------
SMI Re Limited (2) ......................         3,572,396            15.64%
George Jarkesy, Jr. (3)..................        2,097,580              9.97%
Top Tier Investments (4).................        1,228,837              5.96%
Warren Lau ..............................          862,748              4.19%
Terry H. Wesner (5) .....................          575,920              2.75%
David B. McWilliams (6)..................          384,625              1.84%
Robert H. Gow ...........................          342,500              1.66%
C. William Rouse (7).....................          238,135              1.15%
Anthony N. Kamin (8).....................          121,667                *
Brian E. Rodriguez (9)...................           53,334                *
Paul M. Frison (10)......................           28,333                *
All Directors  and Executive  Officers as
a group (7 persons)                                 1,744,513           8.13%
- -----------------
* Less than 1%.

(1)  Ownership  percentages  reflected  in the column  "Percentage  of Class" is
     based on 20,609,545 shares of common stock issued and outstanding as of the
     Record Date.

(2)  Address: Ansbacher Bank Limited, 1 Bank Lane, Nassau, The Bahamas. Includes
     2,231,091  shares of common  stock that SMI Re Limited  may  purchase  upon
     exercise of warrants by December 2005.

(3)  Address:  18205  Burkhardt Road,  Tomball,  Texas 77377.  Includes  439,325
     shares of common  stock that Mr.  Jarkesy  may  purchase  upon  exercise of
     warrants by December 2005.

(4)  Address: 50 California Street, Suite 3000, San Francisco, California 94111.

(5)  Includes  348,625  shares of common stock that Mr. Wesner may purchase upon
     exercise of options and warrants that are  currently  vested or will become
     vested by December 2005.

(6)  Includes  320,369  shares of common stock that Mr.  McWilliams may purchase
     upon  exercise of options and warrants  that are  currently  vested or will
     become vested by December 2005.

(7)  Includes  75,215  shares of common stock that Mr.  Rouse may purchase  upon
     exercise of options and warrants that are  currently  vested or will become
     vested by December 2005.

(8)  Includes  21,667  shares of common stock that Mr.  Kamin may purchase  upon
     exercise of stock options that are  currently  vested or will become vested
     by December 2005.

(9)  Consists of 53,333  shares of common stock that Mr.  Rodriguez may purchase
     upon  exercise of stock  options that are  currently  vested or will become
     vested by December 2005.

(10) Consists of 28,333 shares of common stock that Mr. Frison may purchase upon
     exercise of stock options that are  currently  vested or will become vested
     by December 2005.


                                       4




                        EXECUTIVE OFFICERS AND DIRECTORS

     The following table sets forth certain information  regarding the Company's
current directors and executive  officers.  The Company's executive officers are
elected  by the board of  directors  and shall  serve at the  discretion  of the
board.  All of the current  directors serve until the next annual  stockholders'
meeting or until their successors have been duly elected and qualified.

      Name                                Age      Position
      David B. McWilliams                 62       President and Chief Executive
                                                   Officer, Director
      Robert H. Gow                       72       Chairman of the Board
      C. William Rouse                    58       Chief Financial Officer
      Anthony N. Kamin                    45       Director
      Paul M. Frison                      68       Director
      Brian E. Rodriguez                  35       Director
      Terry H. Wesner                     59       Director


     David B.  McWilliams  was appointed  President and Director in August 2004.
From June 2003 to December  2003, Mr.  McWilliams  served as President and chief
executive officer of Bacterial Barcodes,  Inc., a molecular diagnostics company.
From May 2002 to June 2003, Mr.  McWilliams served as chief executive officer of
Signase,  Inc.,  a  cancer  therapy  company.  Mr.  McWilliams  served  as chief
executive   officer  of  Encysive   Pharmaceuticals   Inc.,   a   cardiovascular
therapeutics  company  from June 1992 to March  2002.  Prior to June  1992,  Mr.
McWilliams   served  as  chief  executive  officer  of  Zonagen  Inc.,  a  human
reproductive  products company.  Prior to that time, Mr. McWilliams was a senior
executive with Abbott  Laboratories and a management  consultant with McKinsey &
Co. He currently serves as a director of Novelos Therapeutics,  Inc. and Fairway
Medical  Systems,  Inc. He also serves on the boards of the Texas Healthcare and
Bioscience  Institute and the Houston  Technology  Center. He received an MBA in
finance from the University of Chicago, and a B.A. in chemistry, Phi Beta Kappa,
from Washington and Jefferson College.

     Robert H. Gow was elected  Chairman of the Board in June 2004.  Since 1994,
Mr. Gow has been  president of Yucatan  Bamboo,  Inc., a privately  held company
that raises and produces bamboo products.  From March 1992 to July 1994, Mr. Gow
served as president and chief executive officer of SI Diamond Technology,  Inc.,
a publicly held company  engaged in the  production  of industrial  coatings and
coating equipment.  Between 1985 and March 1992, he devoted substantially all of
his time to the  management  of his personal  investments.  Previously,  Mr. Gow
served as the  president  of  Enterprise  Technologies,  Inc.,  a publicly  held
distributor   of  fuel  oil,  a  consultant  to  Norton  Co.,  a  publicly  held
manufacturer  of abrasives and diamond  drilling  bits;  vice  president of Gulf
Resources  and Chemical  Corp.,  a publicly  held mining and  chemical  company;
president  of  Stratford of Texas,  Inc.,  a public  agricultural  conglomerate;
president  of Zapata  Corp.,  a publicly  held  offshore  drilling  and maritime
support  company;  president  of  Champlain-Zapata  Plastic  Machinery,  Inc., a
subsidiary of Zapata that manufactured plastic molding equipment; and supervisor
of Industrial  Engineering for Norton Co. Mr. Gow graduated from the Yale School
of Engineering in 1955.

     C. William Rouse has served as the Company's Chief Financial  Officer since
May 2004. Prior to May 2004, Mr. Rouse was managing director of Rouse Associates
from  April 1999 until May 2004.  From  January  1995 to April 1999 he was chief
marketing  officer for Futorian  Inc. and from  December 1990 to January 1995 he
was a division  general manager for Masco  Corporation.  Prior to 1990 Mr. Rouse
was  president of BEI, Inc. Mr. Rouse has led several  startups and  turnarounds
and founded several successful companies.

     Anthony N. Kamin has served as a Director  of the  Company  since  December
2004.  Mr.  Kamin  currently  serves as  president  of two  companies:  Eastwood
Investment  Management,  a private equity  multi-strategy  and multi-asset class
manager;  and Interim Medical Management a management services company primarily
in the biotechnology  and medical device fields.  From 1998 to 2003, Kamin was a
venture  partner with Venture  Strategy  Partners.  He is a co-founder  of Nobex
Corporation (oral protein and peptide  delivery) and Hi Fidelity  Entertainment.
He is also currently  Chairman of the Board of Advisors for Devlab, a center for
technology  commercialization  at  Northwestern  University.  He also  serves on
boards  for  Illinois  Technology  Enterprise  Center  (ITEC) in  Chicago,  Real
American  Restaurants,  B2P.com,  and The Cove School for children with learning
disabilities.   Kamin  received  a  Masters  Degree  from  Yale   University  in
International Relations with a concentration in International Law.

     Paul M. Frison has served as a director of the Company since November 2004.
Mr.  Frison  has been  president  and chief  executive  officer  of the  Houston
Technology  Center  since  January  1999.  Before  helping to found the  Houston
Technology  Center in 1999,  Frison  spent 24 years as  president  and/or  chief
executive  officer  building  three  public  companies,   NYSE-listed  LifeMark,


                                       5




NASDAQ-listed  ComputerCraft,  and LifeCell Corp. (LIFC: NASDAQ-NM).  Mr. Frison
currently  serves on the board of  directors of the Houston  Technology  Center,
Micromed Technologies,  Inc., The Institute of Research and Rehabilitation,  The
Entrepreneurship  Institute, The Houston Entrepreneurs Foundation, The Lions Eye
Foundation  - Houston,  Boy Scouts of America - Houston,  Texas  Council of AEA,
Texchange,  and the Advisory  Council of the  University of Houston - College of
Technology.  He  received  his B.A.  from  Occidental  College  in Los  Angeles,
California.

     Brian E.  Rodriguez  has served as a  Director  and  Chairman  of the Audit
Committee  since August 2004.  Mr.  Rodriguez  has served as an  accounting  and
finance  consultant for Jefferson Wells  International  from October 2004 to the
present.  From March 2002 to October,  2004, Mr.  Rodriguez served as controller
and then  director of Finance for JP Mobile  Inc.,  a  privately  held  wireless
software  company  based in  Dallas.  Mr.  Rodriguez  served as  controller  for
ChipData  Incorporated  from  March,  2001 to  March,  2002.  Prior  to that Mr.
Rodriguez was a consultant with Parson Consulting from April 1999 to March 2001.
Mr. Rodriguez has been a Certified Public Accountant in the State of Texas since
May 1995. Mr. Rodriguez began his career in the Business  Assurance  practice of
Cooper & Lybrand in Dallas,  Texas. Mr. Rodriguez holds a B.B.A.  from Texas A&M
University.

     Terry H. Wesner has served as a director of the Company  since August 2005.
Mr. Wesner has served as chief executive  officer of Bernard J. Klein Publishing
and GetMath  Educational  Software since 1996.  Before founding Bernard J. Klein
Publishing  and GetMath  Educational  Software,  Mr.  Wesner was a Professor  of
Mathematics  and  Statistics  at Henry Ford  Community  College and continues to
remain on the faculty.  He also published a successful  series of thirty college
level  mathematics  textbooks  with  McGraw-Hill  Publishers.  Prior to this Mr.
Wesner was a member of the faculty of Harvard  School of Medicine as Director of
Research for the National  Diabetes  Association.  Mr. Wesner graduated Chi Beta
Phi from The  University  of Memphis  with degrees in biology,  mathematics  and
statistics.

Director Independence

     The Board of Directors has determined that each of Messrs.  Gow, Rodriguez,
Kamin,  Frison and Wesner are independent  directors as defined in Rule 10A-3 of
the Exchange  Act. As part of its  analysis,  the Board of Directors  determined
that none of Messrs. Gow,  Rodriguez,  Kamin, Frison and Wesner have a direct or
indirect  material  relationship  with the Company that would interfere with the
exercise of independent judgment.

Compensation Committee

     The Compensation Committee of the Board consists of Messrs. Gow, Frison and
Kamin.  Messrs.  Gow, Frison and Kamin are  independent  directors as defined in
Rule 10A-3 of the Exchange Act. The Compensation  Committee reviews and approves
salaries and incentive compensation for the Company's executive officers.

Audit Committee

     The Audit Committee of the Board consists of three non-employee  directors,
Messrs.  Gow , Rodriguez and Wesner.  Each of Messrs.  Gow, Rodriguez and Wesner
are  independent  as  defined  in Rule  10A-3 of the  Exchange  Act.  The  Audit
Committee  engages the  Company's  independent  auditors,  reviews the Company's
financial  controls,  evaluates  the scope of the annual  audit,  reviews  audit
results,  consults with management and the Company's  independent auditors prior
to the presentation of financial statements to shareholders and, as appropriate,
initiates  inquiries into aspects of the Company's internal  accounting controls
and financial affairs.  The Board has determined that Mr. Rodriguez qualifies as
an "audit  committee  financial  expert" as defined by Item 401(e) of Regulation
S-B of the Securities Act of 1933.

Nominating Committee

     The Nominating Committee consists of four non-employee  directors,  Messrs.
Gow, Frison, Kamin and Wesner. Each of Messrs. Gow, Frison, Kamin and Wesner are
independent  as  defined  in Rule  10A-3 of the  Exchange  Act.  The  Nominating
Committee interviews and reviews the background  experience of potential members
to the Board.


                                       6




Executive Compensation

     The following  tables  contain  compensation  data for our named  executive
officers for the fiscal year ending December 31, 2004.

                           Summary Compensation Table
                           --------------------------




                                                 Annual                          Long Term
                                              Compensation                  Compensation Awards
           Name and                             Salary          Bonus      Securities Underlying        All Other
     Principal Positions           Year           ($)             ($)           Options (#)          Compensation ($)
     -------------------           ----           ---             ---           -----------          ----------------
                                                                                            
David B. McWilliams (1)            2004          73,000           -             370,000 (2)                 -
                                   2003            -              -                  -                      -
                                   2002            -              -                  -                      -

Warren Lau (3)                     2004          98,000           -                  -                      -
                                   2003            -              -                  -                      -
                                   2002            -              -                  -                      -
Jason Otteson (4)
                                   2004          42,000           -                  -                      -
                                   2003         102,000           -                24,000                   -
                                   2002         102,000           -                  -                      -



(1)  Served as chief executive officer since August 2004.
(2)  See "Executive Employment Contracts" for a discussion of the option.
(3)  Served as chief executive officer from June 2004 through August 2004.
(4)  Served as chief executive officer until June 2004.


             Option Grants in Last Fiscal Year - Individual Grants
             -----------------------------------------------------




                             Number of Securities        % of Total Options    Exercise/Base Price    Expiration
           Name                 Options Granted        Granted to Fiscal Year       ($/Share)            Date
           ----                 ---------------        ----------------------       ---------            ----
                                                                                                 
David B. McWilliams                 370,000                     32%                   $3.00           August 2009
Warren Lau                             -                         -                      -                  -
Jason Otteson                          -                         -                      -                  -




                Options Exercises and Fiscal 2004 Year End Values
                -------------------------------------------------




                              Number of Shares                          Value of Unexercised
                           Underlying Unexercised                       In-the-Money Options
                        Options at December 31 2004                    at December 31 2004 (1)
                       ---------------------------------------------------------------------------------

          Name         Exercisable            Unexercisable        Exercisable             Unexercisable
          ----         -----------            -------------        -----------             -------------
                                                                         
David McWilliams         50,000                 320,000     $        170,000    $            1,088,000
Warren Lau                    -                       -                    -                         -
Jason Otteson                 -                       -                    -                         -



(1)  The value of "in-the-money" stock options represents the difference between
     the $3.00 exercise price of such options and the fair market value of $6.40
     per share of common stock as of December 31, 2004, the closing price of the
     common stock reported on the OTC Bulletin Board.


                                       7




     No options were  exercised  during the fiscal year ended December 31, 2004.
No stock appreciation rights were outstanding as of December 31, 2004.

Executive Employment Contracts

     Mr.  David B.  McWilliams  has an existing  employment  agreement  with the
Company that he entered into effective August 23, 2004. Mr.  McWilliams  current
agreement for the position of chief executive  officer is at an annual salary of
$250,000 and may be terminated by the Company or Mr.  McWilliams at any time for
any or no reason.  Mr.  McWilliams  has the right to purchase  370,000 shares of
Company common stock  exercisable at a price per share of $3.00, of which 10,000
shares of Company  common  stock  shall vest on the 1st day of each month of Mr.
McWilliams employment.  In January 2005, Mr. McWilliams was granted an option to
purchase  50,000 shares of common stock at a purchase  price of $3.00 per share,
of which  one-third  vested on the date of grant,  one-third  shall  vest on the
first  anniversary of the grant date and the remaining  one-third  shall vest on
the second anniversary of the grant date.

     Charles  William "Bill" Rouse  employment  agreement,  effective  April 28,
2004, as amended,  expires April 28,  2006,and  provides for an annual salary of
$180,000.  Pursuant to his  employment  agreement,  Mr. Rouse  acquired  150,000
shares at a purchase  price of $0.10 per share in June 2004.  Mr.  Rouse has the
right to purchase 100,000 shares of Company common stock  exercisable at a price
per share of $3.00, of which  one-third shall vest on each of the first,  second
and third anniversary of Mr. Rouse's employment.  In January 2005, Mr. Rouse was
granted an option to purchase  50,000 shares of common stock at a purchase price
of $3.00 per share,  of which one-third  vested on the date of grant,  one-third
shall  vest on the  first  anniversary  of the  grant  date  and  the  remaining
one-third shall vest on the second anniversary of the grant date.

Related Party Transactions

     There are no  related  party  transactions  other  than  what is  disclosed
herein.

     WHETHER OR NOT YOU PLAN TO ATTEND THE  SPECIAL  MEETING,  PLEASE  COMPLETE,
     SIGN,  DATE,  AND PROMPTLY  RETURN THE  ACCOMPANYING  PROXY IN THE ENCLOSED
     ENVELOPE.  YOU MAY  REVOKE  YOUR  PROXY  AT ANY TIME  PRIOR TO THE  SPECIAL
     MEETING.  IF YOU DECIDE TO ATTEND THE  SPECIAL  MEETING  AND WISH TO CHANGE
     YOUR PROXY  VOTE,  YOU MAY DO SO  AUTOMATICALLY  BY VOTING IN PERSON AT THE
     MEETING.

THANK YOU FOR YOUR ATTENTION TO THIS MATTER.  YOUR PROMPT  RESPONSE WILL GREATLY
FACILITATE ARRANGEMENTS FOR THE SPECIAL MEETING.


By Order of the Board of Directors

/s/ROBERT H. GOW

Robert H. Gow, Chairman

October 14, 2005
The Woodlands, Texas


                                       8




                                   EXHIBIT "A"


Article IV.

     The aggregate  number of shares which the Corporation  shall have authority
to issue is one  hundred ten million  (110,000,000),  consisting  of one hundred
million  (100,000,000)  shares of common stock  having $0.05 par value  ("Common
Stock"),  and ten million  (10,000,000)  shares of preferred stock having no par
value ("Preferred Stock").

     Shares of  Preferred  Stock of the  Corporation  may be issued from time to
time in one or more classes or series,  each of which class or series shall have
such  distinctive  designation  or title as shall be  determined by the Board of
Directors of the Corporation ("Board of Directors") prior to the issuance of any
shares  thereof.  Each such class or series of  Preferred  Stock shall have such
voting powers,  full or limited,  or no voting powers,  and such preferences and
relative,   participating,   optional   or  other   special   rights   and  such
qualifications,  limitations or restrictions thereof, as shall be stated in such
resolution  or  resolutions  providing  for the issue of such class or series of
preferred  stock as may be adopted  from time to time by the Board of  Directors
prior to the issuance of any shares  thereof  pursuant to the  authority  hereby
expressly vested in it, all in accordance with the laws of the State of Texas.


                                      A-1




                                  FORM OF PROXY
                              PHARMAFRONTIERS CORP.
                         SPECIAL MEETING OF SHAREHOLDERS
                                NOVEMBER 11, 2005

                              PHARMAFRONTIERS CORP.


THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The  undersigned  shareholder of  PharmaFrontiers  Corp.,  ("the  Company")
hereby acknowledges receipt of the Notice of Special Meeting of Shareholders and
appoints  Robert H. Gow or David B. McWilliams and each of them, with full power
of substitution,  as Proxy or Proxies to vote as specified in this Proxy all the
shares of common stock of the Company of the  undersigned at the Special Meeting
of Shareholders of the Company to the held at 2635 N. Crescent Ridge Drive,  The
Woodlands,  Texas 77381, at 3:00 p.m., Central Time, Friday,  November 11, 2005,
and any and all adjournments or postponements thereof. Either of such Proxies or
substitutes  shall  have and may  exercise  all of the  powers  of said  Proxies
hereunder.  The  undersigned  shareholder  hereby  revokes  any proxy or proxies
heretofore executed for such matters.

THIS  PROXY,  WHEN  PROPERLY  EXECUTED,  WILL BE VOTED IN THE MANNER AS DIRECTED
HEREIN BY THE UNDERSIGNED SHAREHOLDER.  IF NO DIRECTION IS MADE, THIS PROXY WILL
BE VOTED FOR THE  AMENDMENT TO THE ARTICLES OF  INCORPORATION.  THE  UNDERSIGNED
SHAREHOLDER  MAY  REVOKE  THIS  PROXY  AT ANY  TIME  BEFORE  IT IS  VOTED BY THE
DELIVERING  TO THE SECRETARY OF THE COMPANY  EITHER A WRITTEN  REVOCATION OF THE
PROXY OR A DULY  EXECUTED  PROXY  BEARING A LATER DATE,  OR BY  APPEARING AT THE
SPECIAL MEETING AND VOTING IN PERSON.


THE BOARD OF DIRECTORS  RECOMMENDS A VOTE "FOR" THE AMENDMENT TO THE ARTICLES OF
INCOPORATION.  PLEASE MARK,  SIGN, DATE, AND RETURN THIS CARD USING THE ENCLOSED
RETURN ENVELOPE.

1.   To approve an  amendment  to the  Company's  Articles of  Incorporation  to
     increase  the  aggregate  number of shares of common stock  authorized  for
     issuance from 50 million shares to 100 million shares.


                                         For          Against        Abstain
                                         ---------------------------------------
                                         [  ]          [  ]            [  ]


     DATED:
            -----------------------      ---------------------------------------
                                         [Signature]


                                         ---------------------------------------
                                         [Signature if jointly held]


                                         ---------------------------------------
                                         [Printed Name]


                                  End of Filing




                                  UNITED STATES
                         SECURITIES EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of

                       The Securities Exchange Act of 1934

       Date of Report (Date of earliest event reported): October 26, 2005.

                              PHARMAFRONTIERS CORP.
- --------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

       Texas                        000-25513                     760333165
- ------------------------    --------------------------      --------------------
(State of organization)      (Commission File Number)           (IRS Employer
                                                             Identification No.)


2635 N. Crescent Ridge Drive
The Woodlands, Texas                                                77381
- ----------------------------------------                         ------------
(Address of principal executive offices)                          (Zip Code)

Registrant's Telephone Number, including area code: (281) 272-9331

Former name or former address, if changed since last report: Not Applicable

Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions:

|_|  Written communications pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

|_|  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR
     240.14a- 12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act (17 CFR 240.13e-4(c))




Item 5.02. Departure of Directors or Principal Officers; Election of Directors;
           Appointment of Principal Officers.

     On October 26, 2005, Brian E. Rodriguez, submitted his resignation as a
member of the board. The circumstances surrounding his resignation are contained
in his resignation letter filed herewith as Exhibit 17.1. The Special Committee
with its independent counsel will review the reasons surrounding Mr. Rodriguez's
resignation and will provide any appropriate recommendations to the Board.

     The Board of Directors has reconstituted the audit committee to consist of
Messrs. Boveroux and Wesner. Mr. Boveroux will serve as the audit committee
financial expert and Chairman.


Item 9.01. Financial Statements and Exhibit

      (c)  Exhibits

The following exhibits are to be filed as part of this 8-K:

     EXHIBIT NO.             IDENTIFICATION OF EXHIBIT
     ----------              -------------------------

       17.1                  Letter of resignation.
       99.1                  Press Release dated November 1, 2005.




                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                                     PHARMAFRONTIERS CORP.


                                                     By: /s/ David McWilliams
                                                         --------------------
                                                         David McWilliams,
                                                         Chief Executive Officer

DATE: November 1, 2005




                                  EXHIBIT INDEX


Exhibit No.              Description
- -----------              -----------
   17.1                  Letter of resignation.
   99.1                  Press Release dated November 1, 2005.



                                                                    Exhibit 17.1


October 26, 2005


PharmaFrontiers Corp.
2635 N. Crescent Ridge Drive
The Woodlands, TX 77381

To the Board of Directors:

Please consider this letter as my formal notice of resignation as a member of
the board of directors of PharmaFrontiers Corporation, effective immediately. As
a director of PharmaFrontiers over the last fourteen months, I have observed a
number of irregularities, as management appears to pursue its own interests
without regard to duties of shareholders, unbridled by the board of directors.
In this regard, I share Robert Gow's views and concerns. In addition to Bob's
observations, I have on several occasions been excluded from directors' meetings
through what appeared to be concerted efforts by management to schedule meetings
at times making it impossible for me to attend. Further, I have observed that
despite specific instructions and mandates given to management by the board of
directors, management appears to be operating on its own agenda, ignoring such
mandates and instructions with no ramifications.

I believe any outside observer would conclude that the judgment of the company's
board of directors has been supplanted by the agenda of the company's officers.
I have attempted to reverse this situation, but like Bob Gow, find it impossible
to continue under the circumstances.

Sincerely,



Brian E. Rodriguez



                                                                    Exhibit 99.1

        PharmaFrontiers Corp. Reconstitutes Its Audit Committee

    THE WOODLANDS, Texas--(BUSINESS WIRE)--Nov. 1,
2005--PharmaFrontiers Corp. (OTCBB:PFTR), a company involved in the
development and commercialization of cell therapies, announced today
that Brooks Boveroux, Chairman of the Board of Directors of the
Company, has been unanimously elected to chairman of the audit
committee, effective immediately. Mr. Boveroux, age 62, is replacing
Brian Rodriguez, who has resigned from both the board of directors and
his position as chairman of the audit committee.
    "I am pleased to be taking on the role as chairman of the audit
committee at this important time," said Mr. Boveroux. "My fellow Board
members and I thank Brian for helping PharmaFrontiers achieve a
successful reverse merger and wish him well in his future endeavors.
This is an exciting time as we prepare to implement our upcoming Phase
IIb trials for Tovaxin(TM) in Multiple Sclerosis. We are encouraged
about the power of our technology to treat this devastating disease."
    Mr. Boveroux's career has spanned over two decades of senior level
financial positions with public and private companies both in the
research stage and those marketing approved products in the health
care industry. His last position was chief financial officer of Imcor
Pharmaceutical Co., a specialty pharmaceutical company, from which he
retired in 2004. Mr. Boveroux has held the post of vice president of
finance for several prominent biotechnology companies including
Biogen, Inc., ImClone Systems, Inc. and The Liposome Company, Inc.
    David McWilliams, chief executive officer of PharmaFrontiers
Corp., commented, "Mr. Boveroux's public company financial experience
will be a key asset to our audit committee. This is the ideal time in
the Company's development to appoint an audit committee chairman who
possesses a wealth of financial knowledge and experience."

    About PharmaFrontiers Corp.

    PharmaFrontiers' strategy is to develop and commercialize cell
therapies to treat several major disease areas such as cardiac and
pancreatic conditions and Multiple Sclerosis. PharmaFrontiers owns
patented and proprietary individualized cell therapies that are in FDA
Phase I/II human dose ranging clinical trials to evaluate their safety
and effectiveness in treating MS. The company also holds the exclusive
worldwide license from the University of Chicago, through its prime
contractor relationship with Argonne National Laboratory, for patents
relating to the use of adult pluripotent stem cells derived from
patients' own circulating blood.

    Safe Harbor Statement

    This press release contains "forward-looking statements,"
including statements about PharmaFrontiers' growth and future
operating results, discovery and development of products, strategic
alliances and intellectual property, as well as other matters that are
not historical facts or information. These forward-looking statements
are based on management's current assumptions and expectations and
involve risks, uncertainties and other important factors, specifically
including those relating to PharmaFrontiers' ability to obtain
additional funding, develop its stem cell technologies, achieve its
operational objectives, and obtain patent protection for its
discoveries, that may cause PharmaFrontiers' actual results to be
materially different from any future results expressed or implied by
such forward-looking statements. PharmaFrontiers undertakes no
obligation to update or revise any such forward-looking statements,
whether as a result of new information, future events or otherwise.



    CONTACT: PharmaFrontiers Corp., The Woodlands
             C. William Rouse, 281-775-0608
             brouse@pharmafrontierscorp.com
             or
             Investor Relations Contacts:
             Lippert/Heilshorn & Associates
             Kim Sutton Golodetz, 212-838-3777
             kgolodetz@lhai.com
             or
             Bruce Voss, 310-691-7100
             bvoss@lhai.com
             or
             Media Relations Contact:
             Lippert/Heilshorn & Associates
             Mark Stuart, 310-691-7100
             mstuart@lhai.com