SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                             -----------------------

                                    FORM 8-K

                                 CURRENT REPORT


                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934


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       Date of Report (Date of earliest event reported): November 30, 2005


                                  CHATTEM, INC.
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             (Exact name of registrant as specified in its charter)


       Tennessee                       0-5905                    62-0156300
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(State of incorporation)        (Commission File No.)          (IRS Employer
                                                             Identification No.)


               1715 West 38th Street, Chattanooga, Tennessee 37409
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          (Address of principal executive offices, including zip code)


                                 (423) 821-4571
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              (Registrant's telephone number, including area code)





Item 1.01.  Entry into a Material Definitive Agreement
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     On November 30, 2005, Chattem,  Inc. (the "Company"),  and its wholly owned
subsidiary,  Signal  Investment & Management Co., entered into an Asset Purchase
and Sale Agreement (the "Purchase Agreement") with The Mentholatum Company, Inc.
and The  Mentholatum  Company of Canada Ltd.  (collectively,  the  "Purchaser"),
regarding the sale of the Company's pHisoderm(R) line of skin care products, for
a purchase price of $8.5 million plus inventories of approximately $1.1 million.
Of the total  purchase  price,  $2.9 million is being held in escrow  subject to
certain post-closing  conditions,  the preponderance of which are expected to be
satisfied by February 2006. The closing of the transactions  contemplated by the
Purchase Agreement also occurred on November 30, 2005. The foregoing description
of the terms and  conditions  of the Purchase  Agreement  does not purport to be
complete  and is  qualified  in  its  entirety  by  reference  to  the  Purchase
Agreement,  a copy of which is attached to this Form 8-K as Exhibit  10.1 and is
incorporated herein by reference.  A copy of the press release dated December 5,
2005 announcing the transaction is attached hereto as Exhibit 99.1.

     Statements   in  this  Form  8-K  which  are  not   historical   facts  are
forward-looking   statements  within  the  meaning  of  the  Private  Securities
Litigation Reform Act of 1995. These  forward-looking  statements involve risks,
uncertainties  and  assumptions  that could cause actual outcomes and results to
differ materially from those expressed or projected.

Item 9.01  Financial Statements and Exhibits
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     (c)  The following exhibits are being furnished herewith:

     Exhibit No.    Exhibit Description
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     10.1           Asset Purchase and Sale Agreement dated November 30, 2005 by
                    and between Chattem,  Inc.,  Signal  Investment & Management
                    Co.,  The  Mentholatum  Company,  Inc.  and The  Mentholatum
                    Company of Canada Ltd.

     99.1           Press Release dated December 5, 2005.





                                   SIGNATURES
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     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.


December 5, 2005                         CHATTEM, INC.

                                         By: /s/ Theodore K. Whitfield, Jr.
                                            ------------------------------------
                                             Theodore K. Whitfield, Jr.
                                             Vice President and General Counsel





                                  EXHIBIT INDEX

Exhibit No.         Exhibit Description
- -----------         -------------------

     10.1           Asset Purchase and Sale Agreement dated November 30, 2005 by
                    and between Chattem,  Inc.,  Signal  Investment & Management
                    Co.,  The  Mentholatum  Company,  Inc.  and The  Mentholatum
                    Company of Canada Ltd.

     99.1           Press Release dated December 5, 2005.