UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K
                                 Current Report


                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934



                Date of Report (date of earliest event reported):

                                 March 21, 2006


                     MEDICAL STAFFING NETWORK HOLDINGS, INC.
             (Exact name of registrant as specified in its charter)


          Delaware                   1-31299                      65-0865171
- ----------------------------      ------------               -------------------
(State or other jurisdiction      (Commission                  (IRS Employer
      of incorporation)           File Number)               Identification No.)

                901 Yamato Road, Suite 110, Boca Raton, FL 33431
                ------------------------------------------------
                    (Address of principal executive offices)

        Registrant's telephone number, including area code: 561-322-1300
                                                            ------------

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions: (see General Instruction A.2. below):

     |_| Written communications pursuant to Rule 425 under the Securities Act
(17 CFR 230.425)

     |_| Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17
CFR 240.14a-12)

     |_| Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

     |_| Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))



Item 7.01.     Regulation FD Disclosure.

               The registrant is attaching a copy of a press release dated
March 21, 2006, as Exhibit 99.1.


Item 9.01.     Financial Statements and Exhibits.

     (a)       Not Applicable.

     (b)       Not Applicable.

     (c)       Not Applicable.

     (d)       Exhibits:

               99.1            Press release dated March 21, 2006.

Limitation on Incorporation by Reference

               In accordance with General Instruction B.2 of Form 8-K, the
information in this report (including the exhibit) is furnished pursuant to Item
7.01 and shall not be deemed to be "filed" for the purposes of Section 18 of the
Securities Exchange Act of 1934, as amended, or otherwise subject to liabilities
of that Section, unless we specifically incorporate it by reference in a
document filed under the Securities Act of 1933 or the Securities Exchange Act
of 1934. The filing of this Current Report on Form 8-K is not an admission as to
the materiality of any information in this report that is required to be
disclosed solely by Regulation FD.








                                    SIGNATURE

               Pursuant to the requirements of the Securities Exchange Act of
1934, the registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.



Date: March 21, 2006                                    MEDICAL STAFFING NETWORK
                                                        HOLDINGS, INC.



                                                        By: /s/ Kevin S. Little
                                                            --------------------
                                                            Kevin S. Little
                                                            President




                                  EXHIBIT INDEX

Exhibit No.    Description

99.1           Press Release dated March 21, 2006.