UNITED STATES

                         SECURITIES EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of

                       The Securities Exchange Act of 1934

        Date of Report (Date of earliest event reported): April 13, 2006


                              PHARMAFRONTIERS CORP.
- --------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

          Texas                       000-25513                  76-0333165
          -----                       ---------                  ----------
 (State of organization)       (Commission File Number)         (IRS Employer
                                                             Identification No.)



         2635 N. Crescent Ridge Drive
             The Woodlands, Texas                                   77381
             --------------------                                   -----
   (Address of principal executive offices)                      (Zip Code)

Registrant's Telephone Number, including area code: (281) 272-9331

Former name or former address, if changed since last report: Not Applicable

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions:


|_| Written communications pursuant to Rule 425 under the Securities Act
    (17 CFR 230.425)

|_| Soliciting  material pursuant to Rule 14a-12 under the Exchange Act
    (17 CFR 240.14a-12)

|_|  Pre-commencement communications pursuant to Rule 14d-2(b) under the
     Exchange Act (17 CFR 240.14d-2(b))

|_|  Pre-commencement communications pursuant to Rule 13e-4(c) under the
     Exchange Act  (17 CFR 240.13e-4(c))




Item 1.01         Entry into a Material Definitive Agreement

         Financing

         On April 13, 2006,  PharmaFrontiers Corp. (the "Company") closed upon a
transaction  in which the  Company  issued  46,000,000  shares of the  Company's
common stock and warrants to purchase  23,000,000 shares of the Company's common
stock for  $23,000,000 to certain  institutional  and accredited  investors (the
"Transaction"). In connection with the Transaction, the Company agreed to hold a
shareholder's  meeting by June 30,  2006 to vote on a proposal to effect a 1 for
10 reverse split of the Company  common stock that will not reduce the number of
shares of common stock the Company is authorized to issue.  Additionally,  three
board members resigned at the closing of the Transaction, two new directors were
appointed to fill two vacancies and the Company  agreed to file a Schedule 14f-1
to appoint a third new  director.  The Company also agreed to take all necessary
action to list the Company's common stock on the Nasdaq Capital Market.

         The warrants will expire in five years,  and are  exercisable  at $0.65
per share only after the Company effects a 1 for 10 reverse split.  The warrants
contain  standard  adjustment   provisions  for  stock  splits,   distributions,
reorganizations,  mergers and consolidations.  The Company has the right to call
the  warrants   commencing  one  year  from  the  effective  date  of  a  resale
registration  statement  if the  closing  bid price  per share of the  Company's
common  stock  equals or exceeds  $1.30 for twenty  consecutive  trading days in
which the daily average  trading  volume of the common stock is at least 200,000
shares. Additionally,  if the resale registration statement is not effective for
any period after April 13,  2007,  then the warrant  holders may exercise  their
warrants on a cashless basis during the period the resale registration statement
is not effective.

         The  Company  has  agreed  to file a  registration  statement  with the
Securities  and  Exchange  Commission  by May 13, 2006 in order to register  the
resale of the shares of common stock issued  pursuant to the Transaction and the
shares issuable upon exercise of the warrants. If the Company fails to meet this
deadline, if the registration statement is not declared effective prior July 12,
2006 or August 11, 2006 (if the Securities and Exchange  Commission  comments on
the registration  statement),  or if the registration statement ceases to remain
effective,  the Company has agreed to pay the  investors  liquidated  damages of
1.5% of the amount invested per 30 day period during such failure,  up to 24% of
the aggregate amount invested.

         The  Company  intends  to conduct an  appropriate  accounting  analysis
consistent with general accepted accounting  principles,  including SFAS 133 and
EITF 00-19, with respect to the securities issued in the Transaction,  which may
result in a portion of the proceeds being classified as a derivative  liability.
Any such  derivative  liability would be measured at each reporting date at fair
value  with the any  change  in fair  value  resulting  in a gain or loss in the
Company's statement of operations.  Any such derivative liability initially will
be reflected in the Company's financial statements for the fiscal quarter ending
on June 30, 2006.

         Additionally,  the Transaction  triggered certain adjustment provisions
contained in the  Company's  series B warrants  and series C warrants  issued in
June and July 2005. Pursuant to the adjustment provisions,  the number of shares
issuable  upon exercise of the series B warrants  increased to 6,037,365  shares
from 4,163,701 shares and the exercise price was reduced to $2.00 from $2.90 per
share.  The number of shares  issuable  upon  exercise  of the series C warrants
increased to 11,105,477  shares from 8,329,108 shares and the exercise price was
reduced to $3.00 from $4.00 per share.

         In connection with the  Transaction,  the Company paid  commissions and
fees to our placement agent,  MDB Capital Group LLC ("MDB"),  and another broker
dealer  for  services  in  connection  with  the  Transaction  an  aggregate  of
$1,754,100  and issued MDB and  another  broker  dealer  three year  warrants to
purchase an aggregate of 2,137,200  shares of common stock at an exercise  price
of $0.50 per share,  exercisable  after the  Company  effects a 1 for 10 reverse
split.  These warrants are not callable,  have a cashless  exercise option,  and
have standard adjustment  provisions.  The Company agreed to register the resale
of the shares underlying the warrants issued to MDB and the other broker dealer.

         This summary description of the financing arrangements does not purport
to be complete  and is qualified in its entirety by reference to the form of the
agreements and the other documents and instruments that are filed as exhibits to
this current report.



         University of Chicago License

         On April 13,  2006,  the  Company  amended  that  certain  Amended  and
Restated  License  Agreement,  dated  December 30, 2004,  with the University of
Chicago with respect to certain payment  obligations of the Company, as follows:
(i) an April 30, 2006  $1,500,000  cash payment  obligation  was extended  until
October  31,  2006;  and (ii) the  obligation  to issue  216,228  shares  of the
Company's  common stock issuable upon the close of the  Transaction was extended
until October 31, 2006.

Item 2.02         Results of Operations and Financial Condition

         The Company  intends to use the net  proceeds of this  Transaction  for
Phase IIb clinical trials on Tovaxin (our multiple sclerosis cell therapy),  the
completion of its GMP manufacturing facility, finalizing preclinical studies and
preparing  the   investigational  new  drug  application  for  stem  cells,  the
development of a T-cell  vaccine for rheumatic  arthritis,  and general  working
capital.  Management  believes that the proceeds  received from the  Transaction
will be sufficient to meet projected operating and capital  expenditures through
the third quarter of 2007.

         Certain  milestones  are expected to occur before the third  quarter of
2007  including a planned  Descriptive  Analysis  which is a  mid-trial  interim
report of the results of the Phase IIb trial.  Other milestones planned to occur
before the third  quarter of 2007 are the  completion  of the Tovaxin Phase I/II
trails  including  the  final  report  for  these  trials  and the  filing of an
investigational  new drug  application  to initiate  human trials in  Rheumatoid
Arthritis.

Item 3.02         Unregistered Sales of Equity Securities

         As more fully described in Item 1.01, the Company issued (i) 46,000,000
shares of Company  common stock and  warrants to purchase a total of  23,000,000
shares of Company  common  stock to 41  "accredited  investors"  as such term is
defined  in Rule 501 under the  Securities  Act of 1933  (the  "Act");  and (ii)
warrants to purchase 2,137,200 shares of Company common stock to MDB and another
broker dealer.  The Company received gross proceeds of $23,000,000  ($21,245,900
proceeds after the deduction of sales commissions) from the private placement.

         The offers and sales were made without  registration  under the Act, or
the securities laws of certain states, in reliance on the exemptions provided by
Section  4(2) of Act and  Regulation  D under the Act and in reliance on similar
exemptions  under  applicable  state laws. The issuance of the Company's  common
stock and the  warrants  issued in the  Transaction  did not  involve any public
offering;  each investor made  representations  regarding its investment intent,
experience and  sophistication;  each investor  either received or had access to
adequate  information about us in order to make an informed investment decision;
having received representations to this effect, we believe that each investor is
an "accredited investor" as that term is defined under Rule 501(a) of Regulation
D; and no advertising or general  solicitation  was made in connection  with the
sale and issuance of the Company's common stock and warrants in the transaction.

Item 5.01         Changes of Control of Registrant

         Pursuant to the  Transaction,  the new investors in the aggregate  will
own approximately  69% of the total  outstanding  shares of the Company's common
stock,  without giving effect to the warrants.  To our knowledge,  the investors
did not act as a group in the  Transaction.  Certain  of the  investors,  due to
their ownership or related ownerships, may be required to file a Schedule 13D or
13G with the Securities and Exchange Commission.

         In addition as discussed  more fully in Item 5.02,  Scott B. Seaman and
Gregory H. Bailey,  M.D. were appointed to the Board of Directors to fill two of
the  vacancies,  and the  Company  agreed to file a Schedule  14f-1 to appoint a
third new director, Mr. David Hung.




Item 5.02         Departure of Directors or Principal  Officers;  Election of
Directors;  Appointment  of Principal Officers

         On April 13, 2006, in connection with the Transaction, Messrs Boveroux,
Kamin  and  Wesner  resigned  as  directors,  and the  remaining  two  directors
subsequently  appointed  Scott B.  Seaman and  Gregory H. Bailey to the Board of
Directors to fill two of the three vacancies.

         For the last ten years,  Mr. Seaman has been the executive  director of
Albert and Margaret Alkek Foundation,  a private foundation primarily supporting
institutions in the Texas Medical Center in Houston,  Texas. Mr. Seaman has held
various  financial  positions  in  companies  affiliated  with the Alkek  family
interests for the last twenty years.  Since January 2003,  Mr. Seaman has served
as chairman and, since July 2004,  president of ICT Management Inc., the general
partner of Impact  Composite  Technology  Ltd.  Since May 2004,  Mr.  Seaman has
served as a member of the investment  committee of Global Hedged Equity Fund LP.
Since September 1986, Mr. Seaman has served as a Secretary and Treasurer for M&A
Properties, Inc.

         Dr.  Bailey,  has served as a managing  director of MDB since May 2004.
From June 2002 to June 2003, Dr. Bailey served as a managing director of Gilford
Securities,  Inc and from 1998 to June  2002,  Dr.  Bailey  served as a managing
director of  Knightsford  Bank Corp.  Since May 2005,  Dr.  Bailey has served as
director of Medivation,  Inc., a public company focused on acquiring  biomedical
technologies. Dr. Bailey holds a M.D. from the University of Western Ontario.

         Prior to the Transaction,  Mr. Seaman, individually owned 50,500 shares
of the Company's  common stock,  series B warrants to purchase  29,000 shares of
the Company's  common stock,  and series C warrants to purchase 53,333 shares of
the Company's  common stock. In addition,  Albert and Margaret Alkek  Foundation
and Alkek & Williams  Ventures,  Ltd, entities in which Mr. Seaman may be deemed
to have voting power and/or  investment  power,  owned in the aggregate  303,334
shares of the  Company's  common  stock,  series B warrants to purchase  219,918
shares of the Company's  common stock, and series C warrants to purchase 404,446
shares of the Company's  common stock. In connection with the  Transaction,  (i)
Mr. Seaman  individually  purchased 150,000 shares of the Company's common stock
and was issued a warrant  to  purchase  75,000  shares of the  Company's  common
stock,  and (ii)  Albert  and  Margaret  Alkek  Foundation  and Alkek & Williams
Ventures,  Ltd,  entities in which Mr. Seaman may be deemed to have voting power
and/or  investment  power,  acquired in the  aggregate  7,500,000  shares of the
Company's  common  stock  and  warrants  to  purchase  3,750,000  shares  of the
Company's  common stock. As an individual  investor in the Transaction and being
deemed to have or share voting power and/or investment power with respect to the
shares of the Company's  common stock and the warrants to purchase the Company's
common  stock held by the  Albert  and  Margaret  Alkek  Foundation  and Alkek &
Williams  Ventures,  Ltd., both of which were investors in the Transaction,  Mr.
Seaman beneficially owns 17.53% of the outstanding shares of the Company.

         In connection with the Transaction, (i) Palantir Group, Inc., an entity
in which Dr. Bailey has voting power and/or investment  power,  acquired 100,000
shares of the Company's  common stock and a warrant to purchase 50,000 shares of
the  Company's  common  stock,  (ii) MDB,  an  entity in which Dr.  Bailey is an
managing  director,  but  disclaims  any voting power and/or  investment  power,
acquired  2,000,000  shares of the  Company's  common  stock  and a  warrant  to
purchase  1,000,000 shares of the Company's common stock, and (iii) MDB received
$1,723,300  for its  services  in the  Transaction  and a  warrant  to  purchase
2,083,300  shares of the Company's common stock.  Dr. Bailey  beneficially  owns
less than 1% of the total outstanding shares of the Company.

         Due to the  resignations  of Messrs  Boveroux,  Kamin and  Wesner,  the
entire  Board of  Directors  is acting  as the  nominating  committee  and audit
committee  and Mr.  Frison  is the sole  member of the  compensation  committee.
Neither Dr.  Bailey nor Mr.  Seaman has been  appointed to any  committee of the
board of  directors.  It is expected  that the  nominating  committee  and audit
committee will be immediately  reconstituted and that one or more directors will
be added to the compensation committee.

         Other than as set forth above,  neither Mr.  Seaman nor Dr. Bailey have
been  involved with a related  transaction  or  relationship  as defined by Item
404(a) of Regulation S-B with the Company.



Item 9.01         Financial Statements and Exhibit

         (c)      Exhibits

The following exhibits are to be filed as part of this 8-K:

     Exhibit No.    Identification of Exhibit
     -----------    -------------------------

       10.1         Purchase Agreement dated April 11, 2006
       10.2         Registration Rights Agreement dated April 11, 2006
       10.3         Form of Warrant issued in connection with April 2006
                    financing
       10.4         Second Amendment to the Amended and Restated License
                    Agreement
       10.5         Form of Warrant issued to MDB Capital Group LLC
       99.1         Press Release dated April 17, 2006
       99.2         Press Release dated April 17, 2006




                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                   PHARMAFRONTIERS CORP.

                                   By:  /s/ David McWilliams
                                   -------------------------
                                   David McWilliams, Chief Executive Officer

DATE:  April 18, 2006






                                  EXHIBIT INDEX

Exhibit No.   Description
- -----------   -----------

   10.1       Purchase Agreement dated April 11, 2006
   10.2       Registration Rights Agreement dated April 11, 2006
   10.3       Form of Warrant issued in connection with April 2006 financing
   10.4       Second Amendment to the Amended and Restated License Agreement
   10.5       Form of Warrant issued to MDB Capital Group LLC
   99.1       Press Release dated April 17, 2006
   99.2       Press Release dated April 17, 2006