Exhibit 99.1 Charles River Laboratories Announces Third-Quarter 2006 Results from Continuing Operations Net Sales Increase 9.0% GAAP EPS of $0.47 and Non-GAAP EPS of $0.56 Company on Target to Achieve Previously Announced Sales and Earnings Guidance for 2006 WILMINGTON, Mass.--(BUSINESS WIRE)--Nov. 6, 2006--Charles River Laboratories International, Inc. (NYSE: CRL) today reported third-quarter and year-to-date 2006 financial results. Net sales from continuing operations increased 9.0% in the third quarter of 2006, to $264.7 million from $242.8 million in the third quarter of 2005. The sales increase was driven by both business segments, with Research Models & Services (RMS) sales increasing 7.3% and Preclinical Services sales increasing 10.6%. Foreign exchange contributed 1.2% to the net sales growth. On a GAAP basis, net income from continuing operations for the third quarter of 2006 was $32.1 million, or $0.47 per diluted share, compared to $29.9 million, or $0.41 per diluted share, for the third quarter of 2005. Results for the third-quarter of 2006 also included $2.4 million, or $0.02 per share, of stock option expense as a result of the Company's adoption on January 1, 2006, of Statement of Financial Accounting Standards No. 123R (SFAS 123R), "Share-Based Payment." On a non-GAAP basis, net income from continuing operations was $38.1 million for the third quarter of 2006, compared to $38.0 million for the same period in 2005. Third-quarter diluted earnings per share on a non-GAAP basis were $0.56, compared to $0.52 per share in the third quarter of 2005. Non-GAAP net income and earnings per share for the third quarter of 2006 excluded $8.8 million, or $0.09 per diluted share, of amortization and stock-based compensation costs associated with the acquisition of Inveresk. Non-GAAP results for the third quarter of 2005 excluded $11.8 million, or $0.11 per diluted share, of Inveresk-related amortization and compensation costs. "We are pleased with our overall performance in the third quarter, which puts us on track to achieve our previously announced sales and earnings guidance for the full year. The quarter was highlighted by improved Research Models and Services sales and continuing demand for outsourced preclinical services," said James C. Foster, Chairman, President and Chief Executive Officer. "While it is apparent that certain large pharmaceutical clients continued to limit their spending on research models and services, a broad range of pharmaceutical and biotechnology clients increased their purchases. In addition, we gained market share in our Research Model business, In Vitro reported another strong quarter, and stable U.S. Transgenic Services sales, while still below last year, declined at a slower rate. Preclinical Services sales also increased, as most of our facilities continued to report strong growth. A slightly less robust mix than in the second quarter moderated the third-quarter growth rate, however, we continue to experience strong demand for the preclinical services we provide." The Company reports results from continuing operations, which exclude results of the Clinical Phase II - IV business (sold on August 16, 2006) and closure of the Interventional and Surgical Services (ISS) business (announced on May 9, 2006). Those businesses are now reported as discontinued operations, and the Company has reclassified historical comparisons accordingly. Including $45.3 million of income tax expense related to the sale of the Clinical Phase II - IV business, the loss from discontinued operations was $48.7 million in the third quarter of 2006. Primarily as a result of the tax expense, the Company reported a consolidated net loss for the third quarter of 2006 of $16.6 million, or $0.24 per diluted share, compared to consolidated net income of $32.1 million, or $0.44 per diluted share, in the third quarter of 2005. Research Models and Services (RMS) Sales for the RMS segment were $127.6 million in the third quarter of 2006, an increase of 7.3% from $118.9 million in the third quarter of 2005. Production sales increased in all geographic locations, with the strongest growth in North America and Europe. A broad range of pharmaceutical and biotechnology customers increased their purchases in the quarter, which more than offset lower sales to certain large pharmaceutical customers who have been moderating purchases in an effort to reduce their costs. Market share gains in both the commercial and academic sectors also contributed to the sales increase. Sales of In Vitro products increased in the quarter, while Transgenic Services in the United States continued to decline, but as expected, at a slower rate. In the third quarter of 2006, the RMS segment's gross and operating margins were lower than in the third quarter of last year, primarily reflecting $0.9 million associated with the adoption of SFAS 123R and continuing softness in Transgenic Services. On both a GAAP and non-GAAP basis, the segment's gross margin was 41.1%, compared to 42.0% for the third quarter of 2005, and the operating margin was 28.8%, compared to 30.9% for the same period last year. Costs of SFAS 123R reduced the third-quarter 2006 GAAP and non-GAAP operating margins by 0.7%. Preclinical Services Results for the Preclinical Services segment now include the Phase I Clinical business, and historical results have been restated accordingly. Third-quarter net sales for the Preclinical Services segment were $137.1 million, an increase of 10.6% from the $123.9 million in the third quarter of 2005. Sales were driven by continuing strong demand from pharmaceutical and biotechnology customers. On a GAAP basis, the Preclinical segment's gross margin was 36.4%, compared to 37.2% for the third quarter of 2005. The operating margin improved to 16.8% from 16.1%, as higher sales and improved operating efficiencies offset the $2.0 million cost associated with adoption of SFAS 123R. On a non-GAAP basis, which excludes $8.6 million of amortization related to the Inveresk acquisition, the third-quarter operating margin was 23.0% compared to 24.6% for the third quarter of 2005, with 123R costs accounting for the decline. Non-GAAP operating income for the third quarter of 2005 excluded amortization related to Inveresk of $10.5 million. Nine-Month Results For the first nine months of 2006, net sales from continuing operations increased by 7.0% to $786.7 million, compared to $735.1 million in the same period in 2005. The negative effect of foreign exchange reduced the nine-month growth rate by approximately 0.7%. On a GAAP basis, net income from continuing operations was $93.4 million, or $1.32 per diluted share, for the first nine months of 2006 compared to $89.2 million, or $1.24 per diluted share, for the same period in 2005. In accordance with SFAS 123R, results for the first nine months of 2006 included $9.2 million, or $0.08 per share, of stock option expense. On a non-GAAP basis, net income from continuing operations was $113.3 million, or $1.60 per diluted share, for the first nine months of 2006 compared to $115.4 million, or $1.60 per diluted share, for the same period in 2005. For the first nine months of 2006, non-GAAP net income excluded the following charges: -- $5.3 million, or $0.05 per diluted share, for cost-saving initiatives implemented in the second quarter of 2006. -- $25.9 million, or $0.23 per share, of amortization and stock-based compensation costs associated with the acquisition of Inveresk. Non-GAAP net income for the first nine months of 2005 excluded Inveresk-related charges of $37.8 million, or $0.36 per diluted share. Including a loss of $184.4 million from discontinued operations, of which $129.2 million resulted from the goodwill impairment recorded in the first quarter of 2006 and $45.3 million was the income tax expense associated with the sale of the Clinical Phase II - IV business, the consolidated net loss for the first nine months of 2006 was $91.0 million, or $1.28 per diluted share, compared to net income of $91.6 million, or $1.28 per diluted share, for the same period in 2005. Research Models and Services (RMS) For the first nine months of 2006, RMS net sales were $387.3 million, a 2.6% increase over $377.6 million for the first nine months of 2005, including a 1.3% negative effect of foreign exchange. On a GAAP basis, the RMS segment gross margin was 42.3% in the first nine months of 2006, compared to 43.5% for the same period last year, and the operating margin was 29.7% compared to 32.3%. On a non-GAAP basis, which excluded the $2.3 million charge associated with the second quarter cost-saving initiatives, the operating margin was 30.3%, compared to 32.3% in the first nine months of 2005. Costs of $3.6 million related to SFAS 123R reduced the GAAP and non-GAAP operating margins for the first nine months of 2006 by approximately 1.0%. Preclinical Services For the first nine months of 2006, Preclinical net sales were $399.3 million, an increase of 11.7% from $357.6 million for the first nine months of 2005. On a GAAP basis, the Preclinical segment gross margin was 35.3% in the first nine months of 2006, compared to 36.2% in the year-ago period, and the operating margin was 14.8% compared to 14.5%. On a non-GAAP basis, the operating margin was 21.9% in the first nine months of 2006 compared to 23.4% in the year-ago period. On a year-to-date basis, the cost of SFAS 123R was $5.5 million, which reduced the GAAP and non-GAAP operating margins by 1.4%. Stock Repurchase Program Charles River presently has a stock repurchase authorization in place from its Board of Directors which provides for the purchase of up to $300.0 million of its common stock. On August 23, 2006, the Company implemented an accelerated stock repurchase (ASR) program under which it repurchased approximately 1.8 million shares of common stock for $75.0 million. Combined with previous purchases made under the existing stock repurchase authorization, the Company has repurchased a total of approximately 6.4 million shares at a cost of $261.4 million. There is currently a balance of approximately $38.6 million available for repurchases under the current authorization. As of September 30, 2006, Charles River had approximately 66.9 million shares of common stock outstanding. Guidance The Company continues to maintain its forward-looking non-GAAP guidance based on continuing operations for 2006, which was originally provided with the first-quarter financial results on May 9, 2006. 2006 GUIDANCE (from continuing operations) - ---------------------------------------------------------------------- Net sales growth (in %) 6% - 8% Sales ($ in millions) $1,050 - $1,075 GAAP EPS estimate $1.73 - $1.79 Q2 cost-saving initiatives $0.05 Inveresk amortization and compensation charges $0.34 ---------------- Non-GAAP EPS estimate $2.12 - $2.18 - ---------------------------------------------------------------------- Webcast Charles River Laboratories has scheduled a live webcast on Tuesday, November 7, at 8:30 a.m. ET to discuss matters relating to this press release. To participate, please go to ir.criver.com and select the webcast link. You can also find the associated slide presentation and reconciliations to comparable GAAP measures on the website. The webcast will be available until 5:00 p.m. ET on November 21, 2006. Use of Non-GAAP Financial Measures This press release contains non-GAAP financial measures which exclude, among other items, amortization of intangible assets and other charges related to the Inveresk acquisition. We exclude these items from the non-GAAP financial measures because they are outside our normal operations. We believe that the inclusion of non-GAAP financial measures in this press release helps investors to gain a meaningful understanding of our core operating results and future prospects without the effect of one-time charges, and is consistent with how management measures and forecasts the Company's performance, especially when comparing such results to prior periods or forecasts. Non-GAAP results also allow investors to compare the Company's operations against the financial results of other companies in the industry who similarly provide non-GAAP results. The non-GAAP financial measures included in this press release are not meant to be considered superior to or a substitute for results of operations prepared in accordance with GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules and regulations. Reconciliations of the non-GAAP financial measures used in this press release to the most directly comparable GAAP financial measures are set forth in the text of, and the accompanying exhibits to, this press release, and can also be found on the Company's website at ir.criver.com. Caution Concerning Forward-Looking Statements This news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "expect," "will," "may," "estimate," "plan," "outlook," and "project" and other similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These statements also include statements regarding the future demand for drug discovery and development products and services, including the outsourcing of these services; the impact of specific actions intended to improve overall operating efficiencies and profitability; expectations regarding stock repurchases; the timing of the opening of new and expanded facilities; future cost reduction activities by our customers; and Charles River's future performance as delineated in our forward-looking guidance, and particularly our expectations with respect to sales growth, efficiency improvements and operating synergies. Forward-looking statements are based on Charles River's current expectations and beliefs, and involve a number of risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those stated or implied by the forward-looking statements. Those risks and uncertainties include, but are not limited to: a decrease in research and development spending, a decrease in the level of outsourced services, or other cost reduction actions by our customers; the ability to convert backlog to sales; special interest groups; contaminations; industry trends; new displacement technologies; USDA and FDA regulations; changes in law; continued availability of products and supplies; loss of key personnel; interest rate and foreign currency exchange rate fluctuations; changes in tax regulation and laws; changes in generally accepted accounting principles; and any changes in business, political, or economic conditions due to the threat of future terrorist activity in the U.S. and other parts of the world, and related U.S. military action overseas. A further description of these risks, uncertainties, and other matters can be found in the Risk Factors detailed in Charles River's Annual Report on Form 10-K as filed on March 14, 2006, as well as other filings we make with the Securities and Exchange Commission. Because forward-looking statements involve risks and uncertainties, actual results and events may differ materially from results and events currently expected by Charles River, and Charles River assumes no obligation and expressly disclaims any duty to update information contained in this news release except as required by law. About Charles River Laboratories Charles River Laboratories based in Wilmington, Massachusetts, partners with global pharmaceutical and biotechnology companies, government agencies and leading academic institutions to advance the drug discovery and development process, bringing drugs to market faster and more efficiently. Charles River's 7,500 employees serve clients worldwide. For more information on Charles River, visit our website at www.criver.com. CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED STATEMENTS OF INCOME (UNAUDITED) (dollars in thousands, except for per share data) Three Months Ended Nine Months Ended ------------------------- ------------------------- September September September September 30, 24, 30, 24, 2006 2005 2006 2005 Total net sales $ 264,660 $ 242,829 $ 786,660 $ 735,129 Cost of products sold and services provided 162,398 146,752 481,783 441,380 ------------ ------------ ------------ ------------ Gross margin 102,262 96,077 304,877 293,749 Selling, general and administrative 41,211 37,407 133,976 117,514 Amortization of intangibles 9,430 11,503 27,882 34,583 ------------ ------------ ------------ ------------ Operating income 51,621 47,167 143,019 141,652 Interest income (expense) (3,604) (3,868) (10,281) (14,964) Other, net 45 (522) (643) (774) ------------ ------------ ------------ ------------ Income before income taxes and minority interests 48,062 42,777 132,095 125,914 Provision for income taxes 15,489 12,349 37,170 35,226 ------------ ------------ ------------ ------------ Income before minority interests 32,573 30,428 94,925 90,688 Minority interests (440) (539) (1,496) (1,446) ------------ ------------ ------------ ------------ Income from continuing operations 32,133 29,889 93,429 89,242 Income (loss) from discontinued businesses, net of tax (48,739) 2,184 (184,401) 2,339 ------------ ------------ ------------ ------------ Net income (loss) $ (16,606) $ 32,073 $ (90,972) $ 91,581 ============ ============ ============ ============ Earnings (loss) per common share Basic: Continuing operations $ 0.48 $ 0.42 $ 1.34 $ 1.29 Discontinued operations $ (0.73) $ 0.03 $ (2.64) $ 0.03 Net income $ (0.25) $ 0.45 $ (1.30) $ 1.33 Diluted: Continuing operations $ 0.47 $ 0.41 $ 1.32 $ 1.24 Discontinued operations $ (0.72) $ 0.03 $ (2.60) $ 0.03 Net income $ (0.24) $ 0.44 $ (1.28) $ 1.28 Weighted average number of common shares outstanding Basic 67,171,270 71,373,628 69,841,647 68,995,945 Diluted 68,053,872 73,372,960 70,829,692 72,942,571 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED) (dollars in thousands) September 30, December 31, 2006 2005 Assets Current assets Cash and cash equivalents $ 253,504 $ 114,821 Trade receivables, net 185,275 171,259 Inventories 71,821 65,128 Other current assets 46,389 26,858 Current assets of discontinued businesses 2,741 41,256 ------------- ------------ Total current assets 559,730 419,322 Property, plant and equipment, net 460,856 387,501 Goodwill, net 1,097,449 1,097,590 Other intangibles, net 155,279 175,021 Deferred tax asset 97,162 68,046 Other assets 131,911 34,709 Long-term assets of discontinued businesses 828 356,020 ------------- ------------ Total assets $ 2,503,215 $ 2,538,209 ============= ============ Liabilities and Shareholders' Equity Current liabilities Current portion of long-term debt $ 24,116 $ 36,263 Accounts payable 23,681 28,727 Accrued compensation 34,152 38,238 Deferred income 78,941 95,564 Accrued liabilities 36,133 38,625 Other current liabilities 36,318 43,581 Current liabilites of discontinued businesses 20,240 30,414 ------------- ------------ Total current liabilities 253,581 311,412 Long-term debt 576,542 259,902 Other long-term liabilities 110,421 116,503 Long-term liabilities of discontinued businesses - 13,661 ------------- ------------ Total liabilities 940,544 701,478 ------------- ------------ Minority interests 9,149 9,718 Total shareholders' equity 1,553,522 1,827,013 ------------- ------------ Total liabilities and shareholders' equity $ 2,503,215 $ 2,538,209 ============= ============ CHARLES RIVER LABORATORIES INTERNATIONAL, INC. SELECTED BUSINESS SEGMENT INFORMATION (UNAUDITED) (dollars in thousands) Three Months Ended Nine Months Ended ------------------- ------------------- September September September September 30, 24, 30, 24, 2006 2005 2006 2005 Research Models and Services Net sales $127,560 $118,882 $387,348 $377,565 Gross margin 52,423 49,984 163,767 164,280 Gross margin as a % of net sales 41.1% 42.0% 42.3% 43.5% Operating income 36,691 36,713 115,170 122,071 Operating income as a % of net sales 28.8% 30.9% 29.7% 32.3% Depreciation and amortization 5,185 5,024 15,457 14,800 Capital expenditures 3,932 5,583 12,281 17,375 Preclinical Services Net sales $137,100 $123,947 $399,312 $357,564 Gross margin 49,839 46,093 141,110 129,469 Gross margin as a % of net sales 36.4% 37.2% 35.3% 36.2% Operating income 22,971 19,947 59,289 51,713 Operating income as a % of net sales 16.8% 16.1% 14.8% 14.5% Depreciation and amortization 15,389 16,510 45,302 50,231 Capital expenditures 39,038 39,831 87,479 51,798 Unallocated Corporate Overhead $ (8,041) $ (9,493) $(31,440) $(32,132) Total Net sales $264,660 $242,829 $786,660 $735,129 Gross margin 102,262 96,077 304,877 293,749 Gross margin as a % of net sales 38.6% 39.6% 38.8% 40.0% Operating income (loss) 51,621 47,167 143,019 141,652 Operating income as a % of net sales 19.5% 19.4% 18.2% 19.3% Depreciation and amortization 20,574 21,534 60,759 65,031 Capital expenditures 42,970 45,414 99,760 69,173 CHARLES RIVER LABORATORIES INTERNATIONAL, INC. RECONCILIATION OF GAAP TO NON-GAAP SELECTED BUSINESS SEGMENT INFORMATION (UNAUDITED) (dollars in thousands) Three Months Ended Nine Months Ended ------------------- ------------------- September September September September 30, 24, 30, 24, 2006 2005 2006 2005 Research Models and Services Net sales $127,560 $118,882 $387,348 $377,565 Operating income 36,691 36,713 115,170 122,071 Operating income as a % of net sales 28.8% 30.9% 29.7% 32.3% Add back: Second-quarter actions - - 2,334 - --------- --------- --------- --------- Operating income, excluding specified charges (Non-GAAP) $ 36,691 $ 36,713 $117,504 $122,071 Non-GAAP operating income as a % of net sales 28.8% 30.9% 30.3% 32.3% Preclinical Services Net sales $137,100 $123,947 $399,312 $357,564 Operating income 22,971 19,947 59,289 51,713 Operating income as a % of net sales 16.8% 16.1% 14.8% 14.5% Add back: Amortization related to acquisition 8,592 10,673 25,381 32,066 Second-quarter actions - - 2,966 - --------- --------- --------- --------- Operating income, excluding specified charges (Non-GAAP) $ 31,563 $ 30,620 $ 87,636 $ 83,779 Non-GAAP operating income as a % of net sales 23.0% 24.7% 21.9% 23.4% Unallocated Corporate Overhead $ (8,041) $ (9,493) $(31,440) $(32,132) Add back: Stock-based compensation related to acquisition 162 1,085 564 5,761 --------- --------- --------- --------- Unallocated corporate overhead, excluding specified charges (Non-GAAP) $ (7,879) $ (8,408) $(30,876) $(26,371) Total Net sales $264,660 $242,829 $786,660 $735,129 Operating income 51,621 47,167 143,019 141,652 Operating income as a % of net sales 19.5% 19.4% 18.2% 19.3% Add back: Amortization related to acquisition 8,592 10,673 25,381 32,066 Stock-based compensation related to acquisition 162 1,085 564 5,761 Second-quarter actions - - 5,300 - --------- --------- --------- --------- Operating income, excluding specified charges (Non-GAAP) $ 60,375 $ 58,925 $174,264 $179,479 Non-GAAP operating income as a % of net sales 22.8% 24.3% 22.2% 24.4% Charles River management believes that non-GAAP financial measures provide useful information to allow investors to gain a meaningful understanding of our core operating results and future prospects, without the effect of one-time charges, consistent with the manner in which management measures and forecasts the Company's performance. The non-GAAP financial measures included are not meant to be considered superior to, or a substitute for results of operations prepared in accordance with GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules and regulations. CHARLES RIVER LABORATORIES INTERNATIONAL, INC. RECONCILIATION OF GAAP EARNINGS TO NON-GAAP EARNINGS (dollars in thousands, except for per share data) Three Months Ended Nine Months Ended ------------------------- ------------------------- September September September September 30, 24, 30, 24, 2006 2005 2006 2005 Net income (loss) $ (16,606) $ 32,073 $ (90,972) $ 91,581 Less: Discontinued operations 48,739 (2,184) 184,401 (2,339) ------------ ------------ ------------ ------------ Net income from continuing operations 32,133 29,889 93,429 89,242 Add back: Amortization related to acquisition 8,592 10,673 25,381 32,066 Stock-based compensation related to acquisition 162 1,085 564 5,761 Second-quarter actions: Severance - 2,556 - Impairment - 2,644 - Other - 100 - Tax effect (2,755) (3,627) (11,350) (11,691) ------------ ------------ ------------ ------------ Net income from continuing operations, excluding specified charges (Non-GAAP) $ 38,132 $ 38,020 $ 113,324 $ 115,378 ============ ============ ============ ============ Calculation of earnings per common share, excluding specified charges (Non-GAAP): Net income for purposes of calculating earnings per share, excluding specified charges (Non-GAAP) $ 38,132 $ 38,020 $ 113,324 $ 115,378 After-tax equivalent interest expense on 3.5% senior convertible debentures - - - 1,463 ------------ ------------ ------------ ------------ Income for purposes of calculating diluted earnings per share, excluding specified charges (Non-GAAP) $ 38,132 $ 38,020 $ 113,324 $ 116,841 ============ ============ ============ ============ Weighted average shares outstanding - Basic 67,171,270 71,373,628 69,841,647 68,995,945 Effect of dilutive securities: 3.5% senior convertible debentures - - - 1,987,465 Stock options and contingently issued restricted stock 752,838 1,677,113 851,755 1,623,966 Warrants 129,764 322,219 136,290 335,195 ------------ ------------ ------------ ------------ Weighted average shares outstanding - Diluted 68,053,872 73,372,960 70,829,692 72,942,571 ============ ============ ============ ============ Basic earnings (loss) per share $ (0.25) $ 0.45 $ (1.30) $ 1.33 Diluted earnings (loss) per share $ (0.24) $ 0.44 $ (1.28) $ 1.28 Basic earnings per share, excluding specified charges (Non-GAAP) $ 0.57 $ 0.53 $ 1.62 $ 1.67 Diluted earnings per share, excluding specified charges (Non-GAAP) $ 0.56 $ 0.52 $ 1.60 $ 1.60 Charles River management believes that non-GAAP financial measures provide useful information to allow investors to gain a meaningful understanding of our core operating results and future prospects, without the effect of one-time charges, consistent with the manner in which management measures and forecasts the Company's performance. The non-GAAP financial measures included are not meant to be considered superior to, or a substitute for results of operations prepared in accordance with GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules and regulations. CONTACT: Charles River Laboratories International, Inc. Susan E. Hardy, 781-262-7616 Corporate Vice President, Investor Relations