EXHIBIT 10.1
                                  ------------

                      FOURTH AMENDMENT TO CREDIT AGREEMENT

     THIS FOURTH AMENDMENT TO CREDIT AGREEMENT (this  "Amendment"),  dated as of
November __, 2006, is by and among CHATTEM,  INC., a Tennessee  corporation (the
"Borrower"),  each  of the  Borrower's  Domestic  Subsidiaries  (individually  a
"Guarantor"  and  collectively  with the Borrower,  the "Credit  Parties"),  the
Persons  identified as lenders on the signature pages hereto (the "Lenders") and
BANK OF AMERICA, N.A., as agent for the Lenders (in such capacity, the "Agent").

                               W I T N E S S E T H

     WHEREAS,  the Credit Parties,  the Lenders, and the Agent have entered into
that  certain  Credit  Agreement  dated as of February 26, 2004 (as amended from
time to time, the "Credit Agreement");

     WHEREAS,  the  Borrower  has  requested  that the Lenders  amend the Credit
Agreement as provided herein; and

     WHEREAS, the Lenders have agreed to amend the Credit Agreement on the terms
and conditions hereinafter set forth.

     NOW, THEREFORE,  in consideration of the agreements  hereinafter set forth,
and for other good and valuable consideration, the receipt and adequacy of which
are hereby acknowledged, the parties hereto agree as follows:

                                     PART I
                                   DEFINITIONS

       Unless otherwise defined herein or the context otherwise requires,
terms used in this Amendment, including its preamble and recitals, have the
meanings provided in the Credit Agreement (as amended hereby).

                                     PART II
                         AMENDMENTS TO CREDIT AGREEMENT

     SUBPART 2.1 The following definition is hereby added to Section 1.1 of
the Credit Agreement in the appropriate alphabetical order to read as follows:

          "Convertible  Senior Notes" means the unsecured  convertible notes due
     2013 issued by the Borrower  containing terms reasonably  acceptable to the
     Agent.

     SUBPART  2.2  The  following  definitions  in  Section  1.1 of  the  Credit
Agreement are hereby amended to read as follows:

          "Change of Control"  means any of the following  events:  either (i) a
     "person" or a "group" (within the meaning of Sections 13(d) and 14(d)(2) of
     the  Securities  Exchange Act of 1934) becomes the  "beneficial  owner" (as
     defined in Rule 13d-3 under the  Securities  Exchange  Act of 1934) of more
     than 35% of the then  outstanding  voting  stock  of the  Borrower,  (ii) a
     majority  of the  Board of  Directors  of the  Borrower  shall  consist  of
     individuals who are not Continuing Directors;  "Continuing Director" means,
     as of any  date of  determination,  (A) an  individual  who on the date two
     years prior to such determination date was a member of the Borrower's Board
     of Directors or (B) any new Director  whose  nomination for election by the
     Borrower's  shareholders  was  approved  by a vote of at  least  75% of the



     Directors  then still in office who either were  Directors  on the date two
     years prior to such determination date or whose nomination for election was
     previously so approved,  (iii) the occurrence of a Change of Control (under
     and as defined in the  Subordinated  Indenture) or (iv) the occurrence of a
     "Change of Control (or any comparable  term) under,  and as defined in, the
     indenture governing the Convertible Senior Notes.

          "Pro Forma Basis" means, in connection with any Permitted Acquisition,
     any Asset  Disposition,  any Restricted Payment permitted by Section 8.7 or
     any prepayment of Subordinated Debt or repayment of the principal amount of
     Convertible  Senior Notes pursuant to Section 8.11,  that such  transaction
     shall be deemed to have  occurred  on the  first  day of the  twelve  month
     period ending on the last day of the  Borrower's  most  recently  completed
     fiscal   quarter  for  which  the  Borrower  has  delivered  the  officer's
     certificate pursuant to Section 7.1(c).

     SUBPART 2.3 Section 5.2 of the Credit  Agreement is hereby  amended to read
as follows:

5.2  Conditions to All Extensions of Credit.

     In  addition to the  conditions  precedent  stated  elsewhere  herein,  the
Lenders shall not be obligated to make, continue or convert Loans (nor shall the
Issuing Lender be obligated to issue any Letter of Credit) hereunder unless:

     (a) Notice.  The Borrower  shall have  delivered (i) in the case of any new
Revolving Loan, a Notice of Borrowing,  duly executed and completed, by the time
specified in Section 2.1, (ii) in the case of any Letter of Credit,  a Letter of
Credit  Application,  duly  executed  and  completed,  by the time  specified in
Section  2.2,  (iii) in the case of any new  Swingline  Loan,  a Swingline  Loan
Notice,  duly executed and  completed,  by the time specified in Section 2.3 and
(iv) in the case of any  continuation  or  conversion of a Loan, a duly executed
and completed Notice of Continuation/Conversion by the time specified in Section
2.4;

     (b) Representations and Warranties. The representations and warranties made
by the  Credit  Parties  in any  Credit  Document  are true and  correct  in all
material respects at and as if made as of such date;

     (c) No Default. No Default or Event of Default shall exist or be continuing
either prior to or after giving effect thereto;

     (d) No Material Adverse Effect.  There shall not have occurred any Material
Adverse Effect;

     (e)  Availability.  Immediately  after giving  effect to the making of such
Loan (and the  application  of the  proceeds  thereof)  or the  issuance of such
Letter  of  Credit,  the  sum  of  the  Revolving  Loans  outstanding  plus  LOC
Obligations  outstanding plus the Swingline Loans  outstanding  shall not exceed
the Revolving Commitment Amount; and

     (f) Compliance with Subordinated Indenture.  The incurrence by the Borrower
of the  Indebtedness  evidenced by such Loan or Letter of Credit is permitted by
the  Subordinated  Indenture,  including  Section 4.09 thereof,  and constitutes
"Senior Indebtedness" as defined therein.



     The   delivery   of  each   Notice  of   Borrowing   and  each   Notice  of
Extension/Conversion  shall  constitute  a  representation  and  warranty by the
Borrower of the  correctness of the matters  specified in subsections  (b), (c),
(d), (e) and (f) above.

     SUBPART 2.4 Section  8.1(j) of the Credit  Agreement  is hereby  amended to
read as follows:

          (j) Indebtedness of the Borrower under the Convertible Senior Notes in
     an aggregate principal amount not to exceed $125,000,000.

     SUBPART 2.5 The  following  sentence is hereby  added at the end of Section
8.7 of the Credit Agreement to read as follows:

     For the  avoidance  of doubt,  the  parties  hereto  agree that (a) nothing
     contained  in this Section 8.7 shall  prohibit the Borrower  from using $26
     million of the proceeds from the issuance of the  Convertible  Senior Notes
     to fund a convertible  note hedge  transaction with an affiliate of Merrill
     Lynch & Co. on the date of the issuance of the  Convertible  Senior  Notes,
     which  transaction  is  designed  to  offset  the  Borrower's  exposure  to
     potential  dilution  of  its  common  stock  upon  the  conversion  of  the
     Convertible  Senior  Notes and (b) the use of such  proceeds  as  described
     above shall not be considered a Restricted Payment.

     SUBPART 2.6 Section 8.9 of the Credit  Agreement  is hereby  amended to add
the following sentence at the end of such Section to read as follows:

     The documentation governing the Convertible Senior Notes may not be amended
     or modified in any material manner without the prior written consent of the
     Required Lenders.

     SUBPART 2.7 Section 8.10 of the Credit  Agreement is hereby amended to read
as follows:

          (a)  8.10 Prepayments of Indebtedness.


          No Credit Party will, nor will it permit any of its  Subsidiaries  to,
     (a) amend or modify (or permit the amendment or modification of) any of the
     terms of any  Indebtedness if such amendment or  modification  would add or
     change any terms in a manner  adverse  to the  Lenders,  including  but not
     limited to,  shortening  final maturity or average life to maturity of such
     Indebtedness  or  requiring  any payment to be made sooner than  originally
     scheduled or increasing the interest rate applicable  thereto or change any
     subordination  provision thereof,  (b) during the existence of a Default or
     Event of Default,  or if a Default or Event of Default would be caused as a
     result  thereof,  make  (or give  any  notice  with  respect  thereto)  any
     voluntary or optional  payment or prepayment  or redemption or  acquisition
     for value of (including,  without limitation, by way of depositing money or
     securities with the trustee with respect thereto before due for the purpose
     of  paying  when  due),   refund,   refinance  or  exchange  of  any  other
     Indebtedness  and (c) make any  repayment  in cash for  Convertible  Senior
     Notes that are  surrendered  by the holders  thereof (or otherwise make any
     payment on the principal of any Convertible  Senior Notes) unless (i) prior
     to any such  repayment,  the Borrower has Sufficient  Liquidity (as defined
     below), (ii) prior to any such repayment, the Borrower shall deliver to the
     Agent a Pro Forma Compliance  Certificate  demonstrating  that after giving
     effect to any such  payment on a Pro Forma  Basis,  the Credit  Parties and
     their  Subsidiaries  would have been in  compliance  with all the financial
     covenants set forth in Section 7.12 and (ii) before and after giving effect
     to any such  repayment,  no Default or Event of Default shall have occurred
     and be continuing.



          For  purposes  hereof,  "Sufficient  Liquidity"  means  cash  and Cash
     Equivalents   (including,   without  limitation,   availability  under  the
     Revolving Committed Amount) in an aggregate amount equal to 125% of the sum
     of the principal amount of the Convertible  Senior Notes contemplated to be
     paid by the Borrower in cash.

     SUBPART  2.8 A new clause (o) is hereby  added at the end of Section 9.1 of
the Credit Agreement following clause (n) thereof to read as follows:

          (o) Convertible  Senior Notes. There shall occur an "Event of Default"
     (or any  comparable  term)  under,  and as defined  in,  the  documentation
     governing the Convertible Senior Notes.

                                    PART III
                           CONDITIONS TO EFFECTIVENESS

     SUBPART 3.1 Effective Date.  This Amendment  shall be and become  effective
upon the Agent's receipt of counterparts of this Amendment,  which  collectively
shall have been duly executed on behalf of the  Borrower,  the  Guarantors,  the
Required Lenders and the Agent.

                                     PART IV
                                  MISCELLANEOUS

     SUBPART  4.1  Representations  and  Warranties.  Each Credit  Party  hereby
represents  and  warrants  to the Agent and the  Lenders  that (a) no Default or
Event of Default  exists  under the Credit  Agreement or any of the other Credit
Documents on and as of the date hereof,  (b) each Credit Party has the requisite
corporate power and authority to execute, deliver and perform this Amendment and
(c) the  representations  and  warranties  set forth in  Section 6 of the Credit
Agreement  are true and correct in all  material  respects as of the date hereof
(except for those which expressly relate to an earlier date).  Each Credit Party
acknowledges  and  confirms  that  the  Borrower's   obligations  to  repay  the
outstanding  principal amount of the Loans are  unconditional and not subject to
any offsets, defenses or counterclaims.

     SUBPART 4.2 Acknowledgment. Each Guarantor hereby acknowledges and consents
to all of the  terms and  conditions  of this  Amendment  and  agrees  that this
Amendment  does not operate to reduce or discharge the  Guarantors'  obligations
under the Credit Agreement or the other Credit Documents.

     SUBPART 4.3  Cross-References.  References in this Amendment to any Part or
Subpart  are,  unless  otherwise  specified,  to such  Part or  Subpart  of this
Amendment.

     SUBPART 4.4 Instrument  Pursuant to Credit  Agreement.  This Amendment is a
Credit  Document  executed  pursuant to the Credit  Agreement  and shall (unless
otherwise expressly indicated therein) be construed, administered and applied in
accordance with the terms and provisions of the Credit Agreement.

     SUBPART 4.5  References  in Other  Credit  Documents.  At such time as this
Amendment  shall  become  effective  pursuant to the terms of Subpart  3.1,  all
references in the Credit Documents to the "Credit  Agreement" shall be deemed to
refer to the Credit Agreement as amended by this Amendment.

     SUBPART 4.6  Counterparts/Telecopy.  This  Amendment may be executed by the
parties hereto in several  counterparts,  each of which shall be deemed to be an
original  and all of  which  shall  constitute  together  but  one and the  same
agreement.  Delivery of executed counterparts of the Amendment by telecopy shall
be  effective  as an original  and shall  constitute  a  representation  that an
original shall be delivered.



     SUBPART 4.7 Governing Law. THIS AMENDMENT  SHALL BE DEEMED TO BE A CONTRACT
MADE UNDER AND GOVERNED BY THE INTERNAL LAWS OF THE STATE OF TENNESSEE.

     SUBPART 4.8  Successors and Assigns.  This Amendment  shall be binding upon
and inure to the benefit of the parties hereto and their  respective  successors
and assigns.

     SUBPART 4.9 General. Except as amended hereby, the Credit Agreement and all
other Credit Documents shall continue in full force and effect.




     IN WITNESS WHEREOF the Borrower, the Guarantors and the Lenders have caused
this Amendment to be duly executed on the date first above written.

BORROWER:                       CHATTEM, INC.,
- --------                        a Tennessee corporation



                                By: /s/ Robert E. Bosworth
                                Name:  Robert E. Bosworth
                                Title: President and Chief Operating Officer


GUARANTORS:                     SIGNAL INVESTMENT & MANAGEMENT CO.,


                                By: /s/ Robert E. Bosworth
                                Name:  Robert E. Bosworth
                                Title: President



                                SUNDEX, LLC,
                                a Tennessee limited liability company

                                By: /s/ Robert E. Bosworth
                                Name:  Robert E. Bosworth
                                Title: President



                                CHATTEM (CANADA) HOLDINGS, INC.,
                                a Delaware corporation

                                By: /s/ Robert E. Bosworth
                                Name:  Robert E. Bosworth
                                Title: President




AGENT:                          BANK OF AMERICA, N.A.,
- -----                           in its capacity as Agent

                                By: /s/ Brian Chiappetta
                                Name:  Brian Chiappetta
                                Title: Assistant Vice President



LENDERS:                        BANK OF AMERICA, N.A.,
- -------                         in its capacity as a Lender

                                By: /s/ John M. Hall
                                Name:  John M. Hall
                                Title: Senior Vice President



                                SUNTRUST BANK

                                By: /s/ Kap Yarbrough
                                Name:  Kap Yarbrough
                                Title: Banking Officer



                                BRANCH BANKING AND TRUST

                                By: /s/ R. Andrew Bream
                                Name:  R. Andrew Bream
                                Title: Senior Vice President



                                NATIONAL CITY BANK

                                By: /s/ Kevin L. Anderson
                                Name:  Kevin L. Anderson
                                Title: Sr. Vice President